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Dissertations / Theses on the topic 'Purine derivatives'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Shubietah, Raqi Moh'd Hasan. "Adsorptive stripping voltammetry as a method of analysis of some pharmaceutical and other purine derivatives." Thesis, Loughborough University, 1995. https://dspace.lboro.ac.uk/2134/11215.

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Adsorptive stripping voltammetry (AdSV) is a recent technique (initially named by Lam, Kalvoda and Kopanica in 1983) in which there is generally a nonelectrolytic accumulation (adsorption) of the determinand followed by a cathodic reductive or anodic oxidative scan. In this work, a hanging mercury drop electrode (HMDE) was used to accumulate several purine derivatives with and without the addition of Cu(lI) in a suitable buffer (usually Britton-Robinson, pH 7.5). In the presence of copper(lI) the copper(l) purine complex was usually accumulated at about -0.1 V. Some of the compounds studied (i

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2

Chen, Xue Bin. "Excretion of purine derivatives by sheep and cattle and its use for the estimation of absorbed microbial protein." Thesis, University of Aberdeen, 1989. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=128449.

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The nucleic acids digested by ruminants are essentially of microbial origin. Absorbed purines are extensively degraded and excreted in urine as allantoin, uric acid, xanthine and hypoxanthine. The measurement of the urinary purine derivatives could be used to estimate the uptake of purines and hence that of microbial protein. 1) Automated methods for measurements of purine derivatives were improved. A HPLC method for determining total adenine and guanine was used to measure the purine contents of mixed rumen bacteria and the digestibility of microbial purines in sheep. 2) Endogenous excretions

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3

Gilliam, Sarah Elizabeth. "The mode of action and therapeutic potential of purine and pyrimidine phosphonylmethoxyalkyl derivatives against bovine herpesvirus-1." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319534.

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4

Dhanda, Anupma. "Novel carbocyclic purine derivatives at TNF- #alpha# inhibitors and novel polyamino acids for asymmetric epoxidation of enones." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367101.

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5

Ahnert, Veronika Sandra [Verfasser]. "Response of urinary purine derivatives excretion to nutritional factors affecting ruminal microbial protein synthesis in cattle / Veronika Sandra Ahnert." Kiel : Universitätsbibliothek Kiel, 2015. http://d-nb.info/1072621436/34.

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6

Oliveira, Lisandre de. "Métodos em nutrição de ruminantes: uso de índices fecais para estimar consumo e estimativa da síntese proteica microbiana ruminal." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/10733.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This study was carried out to evaluate methods in ruminant nutrition: use of fecal index to estimate intake and use of purine or purine derivatives to estimate rumen microbial protein synthesis. Data from three digestibility trials conducted with castrated male lambs fed ryegrass (Lolium multiflorum, Lam) or Cynodon (Cynodon dactylon var dactylon) at different levels of intake were compiled. Intake data were related to faecal excretion of different chemical compounds through regression analysis. Significant regressions with high

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7

Tyagi, Surendera Kumar. "Electrochemical and enzyme-catalyzed oxidation chemistry of some biologically important purine derivatives (uric acid, 9-B-D-ribofuranosyluric acid and xanthosine) /." Full-text version available from OU Domain via ProQuest Digital Dissertations, 1986.

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8

Silva, Júnior Jarbas Miguel da. "Excreção urinária de derivados de purinas e de compostos nitrogenados de zebuínos em pastejo." Universidade Federal de Viçosa, 2014. http://locus.ufv.br/handle/123456789/5825.

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Made available in DSpace on 2015-03-26T13:55:26Z (GMT). No. of bitstreams: 1 texto completo.pdf: 876963 bytes, checksum: 2254ce6044753867875b6bfab3b2249e (MD5) Previous issue date: 2014-07-21<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>This study aimed evaluating the excretion of purine derivatives and nitrogen compounds in zebu cattle grazing, on different days and times within days. The experiment was conducted in the cattle department of the Federal University of Viçosa / MG, using five Nelore heifers with an average body weight of 300 ± 15 kg and 20 months of age, i

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9

Stefanello, Cristiano Miguel. "Avaliação de marcadores internos para estimativa de fluxo de digesta e proteína microbiana no duodeno de ruminantes." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/10849.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The aim of this study was to evaluate the use of internal markers to estimate duodenal flow of digesta and duodenal microbial protein synthesis in cattle and sheep. Data and samples of in vivo digestibility trials, eight trials with sheep (n=204) and two with cattle (n=31) were used. All animals were cannulated in the duodenum, procedure previously conducted at the Laboratory of Food Science and Ruminants Nutrition at the Federal University of Santa Maria and Laboratory of Animal Nutrition and Food Science at the University of the

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10

Zanferari, Filipe. "Quitosana associada a grão de soja integral na alimentação de vacas leiteiras: I. Digestão, metabolismo e desempenho produtivo; II. Avaliação de metodologias para estimativas da digestibilidade aparente total e produção microbiana ruminal." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10135/tde-22062017-143018/.

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A presente tese foi elaborada em três capítulos, correspondente às seções 2, 3 e 4. No primeiro objetivou-se avaliar a associação de quitosana com grão de soja integral nas dietas sobre o consumo, fermentação ruminal, digestibilidade e metabolismo de nutrientes e seus efeitos sobre a produção de leite, perfil de ácidos graxos do leite e a eficiência produtiva de vacas em lactação. Para tal, 24 vacas multíparas da raça Holandesa, oito dessas com cânula ruminal, foram distribuídas em quadrados latinos 4×4 replicados. Os tratamentos foram obtidos por esquema fatorial 2×2 pela combinação de quitos

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11

Raynaud, Isabelle. "Etude des relations structure-activité quantitatives (QSAR) des cytokinines : synthèse et activité biologique de nouvelles molécules actives." Angers, 1996. http://www.theses.fr/1996ANGE0022.

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Un modèle statistique de relations structure-activité de type quantitatif des cytokinines, hormones végétales, a été mis au point. Il a été construit à partir de 26 molécules appartenant aux deux principales classes de cytokinines : les pyridylphenylurées et les purines n#6-substituées. Apres l'analyse conformationnelle de ces 26 molécules, différents alignements ont été construits et testes dans COMFA. Finalement, deux modèles ont été sélectionnés. Ils ont été valides par des échantillons-tests de molécules connues. Le meilleur modèle, ORL1, a ensuite servi pour faire des prédictions d'activi

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12

Braga, Fernanda Gambogi. "Atividades de derivados purínicos em Leishmania amazonensis e Leishmania chagasi." Universidade Federal de Juiz de Fora (UFJF), 2008. https://repositorio.ufjf.br/jspui/handle/ufjf/2914.

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13

Heinzen, Eduardo Luiz. "VariÃveis nutricionais e fisiolÃgicas de ovinos da raÃa Morada Nova de diferentes classes sexuais submetidos Ã restriÃÃo alimentar." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16929.

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nÃo hÃ<br>Este estudo foi realizado com o objetivo de determinar os efeitos da classe sexual e restriÃÃo alimentar sobre o consumo de nutrientes, digestibilidade, derivados de purina, balanÃo de nitrogÃnio, comportamento ingestivo e parÃmetros fisiolÃgicos de cordeiros da raÃa Morada Nova. Trinta e cinco animais (11 machos inteiros, 12 castrados e 12 fÃmeas), com peso mÃdio inicial de 14,5 Â 0,89kg, foram usados em delineamento inteiramente casualizado, em esquema fatorial 3x3, sendo trÃs classes sexuais (machos inteiros, castrados e fÃmeas) e trÃs nÃveis de restriÃÃo alimentar (ad libitum, 30

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14

Heinzen, Eduardo Luiz. "Variáveis nutricionais e fisiológicas de ovinos da raça Morada Nova de diferentes classes sexuais submetidos à restrição alimentar." reponame:Repositório Institucional da UFC, 2016. http://www.repositorio.ufc.br/handle/riufc/18895.

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HEINZEN, Eduardo Luiz. Variáveis nutricionais e fisiológicas de ovinos da raça Morada Nova de diferentes classes sexuais submetidos à restrição alimentar. 2016. 50 f. : Dissertação (Mestrado) - Universidade Federal do Ceará, Centro de Ciências, Departamento de Zootecnia, Programa de Pós-Graduação em Zootecnia. Fortaleza-CE, 2016.<br>Submitted by Eric Santiago (erichhcl@gmail.com) on 2016-08-03T13:37:27Z No. of bitstreams: 1 2016_dis_elheinzen.pdf: 1285825 bytes, checksum: 32955795d549452fb81768336e0dfffc (MD5)<br>Approved for entry into archive by Nádja Goes (nmoraissoares@gmail.com) on 2016-0

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15

Silva, Robson Pinho da. "Comportamento redox e detecção voltamétrica de neurotransmissores, nitrito, derivados purínicos e nitrofural em sensores eletroquímicos à base de carbono." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-02052013-102258/.

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Sistemas químicos capazes de produzir radicais livres OH• e O2•-, responsáveis por danos no DNA, foram estudados em diversos tipos de eletrodos de carbono previamente modificados. Nitrofural, RNO2, foi reduzido mono eletronicamente ao seu respectivo nitro ânion radical, RNO2•-, em eletrodo de pasta de carbono modificado superficialmente com um filme de guanina. O nitro ânion radical atacou a guanina imobilizada na superfície do eletrodo e, esta interação in situ, resultou na formação de cátions radicais de guanina (G+•), que ao interagirem com a guanina (G), foram ident

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16

Leuxe, Charlotte. "Dérivés puriques et physiopathologie de la maladie d’Alzheimer." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS080.

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La maladie d’Alzheimer (AD), pathologie neurodégénérative progressive, est caractérisée par des dépôts β-amyloïdes extracellulaires, des enchevêtrements neurofibrillaires intracellulaires de Tau et une dégénérescence neuronale. A travers les nombreux modèles transgéniques AD disponibles, les connaissances sur les peptides amyloïdes et la protéine Tau ne cessent de progresser. Mais contrairement aux cas génétiques, l’étiologie des cas sporadiques d’AD reste à ce jour idiopathique, rendant difficile d’établir une stratégie thérapeutique efficace. Au cours d’une étude sur l’implication des protéi

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17

Beaty, Michael Graeme. "Reconstructing functions from values and derivatives." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329630.

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18

Collins, Julian M. "The Karlhede classification and derivative bounds." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292428.

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19

Morris, Simon Edward. "Bounded derivations from uniform algebras." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318438.

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20

Gilholm, Kevin. "The zeros of the derivatives of a real entire function of finite order." Thesis, University of York, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239766.

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21

Tang, Peipei. "Petunidin Derivatives from Black Goji and Purple Potato as Promising Natural Colorants, and Their Co-pigmentation with Metals and Isoflavones." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523911769211136.

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22

Leonardi, Antonio. "Design, synthesis of substituted purines, phenylpyrrolidine derivatives, cyclic and acyclic bis (p-nitrobenzenesulfonamides), and in vitro anti-cancer activity against lung, breast and prostate cell lines." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1175.

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Al momento sono stati classificati più di 100 forme di cancro secondo il tipo di cellula inizialmente affetta. Le patologie tumorali sono caratterizzate da una crescita cellulare incontrollata che porta alla formazione di grumi o masse di tessuto che danneggiano l organismo. Lo sviluppo di nuovi farmaci antitumorali è una delle attività prioritarie nell'ambito della ricerca chimico-farmaceutica, non solo per l alta incidenza ma anche per i numerosi inconvenienti legati ai farmaci in uso. Il progetto di ricerca è stato indirizzato al disegno, sintesi e valutazione biologica di nuovi farmaci ant

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23

Cheviet, Thomas. "Ciblage d'enzymes du métabolisme purique chez Plasmodium falciparum : Conception et étude de molécules bioactives." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS121.

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Le paludisme, problème de santé publique mondial, est dû à plusieurs parasites possédant la caractéristique de n'avoir qu'une voie de biosynthèse nucléotidique : la voie de récupération. Dans le cadre d'une conception rationnelle d'inhibiteurs d'enzymes impliqués dans le cycle purique chez Plasmodium Falciparum (un des parasites responsable du paludisme), plusieurs composés ont donné des résultats prometteurs. Le projet de thèse sera consacré d'une part à l'optimisation structurale de ces composé-hits en interaction avec une équipe de biologistes (SAR) et une équipe de structuralistes (relatio

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24

Yam, Noymi. "Molecular interactions of biologically active derivatives of sulfamide with pharmaceutical polymers in solid state." Scholarly Commons, 2009. https://scholarlycommons.pacific.edu/uop_etds/2398.

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Molecular interactions of small molecules with polymers in solid state have numerous applications in pharmaceutical research. This dissertation examines the mechanism of the solid state interactions of the biologically active sulfamide derivatives with polyethylene glycol (PEG) and structurally related polymers. It is shown that in addition to the formation of the eutectic systems, PEG and related polymers cause polymorphic transitions of sulfamide derivatives. A new polymorphic form of a model sulfamate, topiramate, has been discovered and characterized using multiple analytical techniques. T

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25

Liu, Wanbo. "Molecule recognition of nucleic acids, nucleosides, nucleotides, and their derivatives." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/150.

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It has long been known that the efficiency of anticancer drugs is limited by the emergence of resistance due to the evolving repair of such DNA lesions in malignant cells. Therefore, development of pharmaceutical agents, which can interfere with the DNA repair pathways, may represent a novel approach to enhance the cytotoxic effects of chemotherapy by reducing drug resistance. Abasic sites (AP sites) are the key intermediates in the BER pathway and promising targets for BER inhibition. In chapter 2, we report the synthesis of two small molecules specifically targeting at AP sites and the evalu

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26

Shallal, Hassan M. "The discovery and anticancer preclinical investigation of novel piperazinylpyrimidine derivatives designed to target the human kinome." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/158.

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The current dissertation describes a multidisciplinary research project centered on the discovery and investigation of the anticancer activities exhibited by novel piperazinylpyrimidine derivatives designed to target kinases protein family. Primary screening of the antiproliferative effects implemented by these successfully synthesized new agents has resulted in the candidacy of 4 , 15 , and 16 as not only prototype representatives of the class, but surprisingly also as optimized agents for either globally cytotoxic, 16 , or selectively cytostatic, 4 and 15 , agents. Subjecting 4 , 15 , and 16

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27

Nergui, Navchtsetseg, and 倪娜. "Raman and Surface-Enhanced Raman Spectroscopy of Purine Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/89694890714554310529.

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博士<br>國立臺灣大學<br>化學研究所<br>104<br>The thesis proves an experimental basis for the featured characteristics of adenine and demonstrates the conditions for excitation wavelength dependency on vibrational modes to observe the spectral contributions by relative intensities. Purine derivative, adenine is the most ubiquitous of all the heterocyclic compounds in nature. Raman spectroscopy, which provides the signature of molecular vibrational fingerprints, is an emergent method to help identify a substrate and to examine compounds in nature. Raman spectra of adenine powder were acquired using excitat

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28

Rocha, Ashly. "Synthesis of new purine derivatives for SAR studies on Mycobacterium tuberculosis." Master's thesis, 2011. http://hdl.handle.net/1822/18344.

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Dissertação de mestrado em Química Medicinal<br>O diaminomaleonitrilo, um reagente disponível comercialmente, foi tratado com trietilortoformiato para gerar o (Z)-N-(2-amino-1,2-dicianovinil)formimidato de etilo. O último composto fez-se reagir com as aminas primárias para gerar as (Z)-N-(2-amino-1,2- dicianovinil) formamidinas, que na presença de base ciclizam intramolecularmente formando as 5-amino-4-(cianoformimidoil)imidazoles. 6-Cianopurinas foram obtidas por reacção das (Z)-N-(2-amino-1,2-dicianovinil) formamidinas e dos 5-amino-4-(cianoformimidoil) imidazoles com trietilortoformia

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29

Sousa, Raquel. "Evaluation of the anticancer potential of novel purine derivatives in human colon cancer." Master's thesis, 2015. http://hdl.handle.net/1822/34770.

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Dissertação de mestrado em Bioquímica Aplicada<br>Cancer is one of the major problems in today's society and it is responsible for 1 in 8 deaths that occur worldwide. The numbers of diagnosed cases increase each day. Despite all efforts of academic and medical society to achieve more efficient treatments, the patients lose their life quality during the treatment and many die during the treatment. Since many years these disturbing facts lead to the search for more effective and less aggressive treatments. The uncontrolled proliferation is a feature of cancer cells, which results from mutation

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30

Chen, Wen-Sin, and 程文星. "The Study of Double Proton Transfer in Purine Derivatives；The Investigation of DNA Mutation Mechanism." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/04098940329499117233.

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碩士<br>國立中正大學<br>化學研究所<br>88<br>Self - dimerization of 7-Azaindole has long been recognized for undergoing the excited - state double proton transfer (ESDPT) resulting in a large Stokes shifted emission. Such a simple ESDPT process, at molecular level, provides one possible mechanism for the mutation due to a "misprint " of a specific DNA base pair. Through the molecular design we have already explored the spectra and dynamics of proton-transfer propriety among 4-azabenzaimidazole (4ABI), 7-azaindoline (7AZD), 3-Formyl-7-Azaindole and 3-Cyano-7-Azainodole, etc. Unfortunately such 7AI analogues

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31

Wheelhouse, Richard T., Michael C. Bibby, Anna Nicolaou, and Dimitrios Pletsas. "Polar, Functionalized Guanine-O6 Derivatives Resistant to Repair by O6-Alkylguanine-DNA Alkyltransferase: Implications for the Design of DNA-modifying Drugs." 2009. http://hdl.handle.net/10454/3168.

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No<br>The protein O6-alkylguanine-DNA alkyltransferase (Atase) is responsible for the repair of DNA lesions generated by several clinically important anti-cancer drugs; this is manifest as active resistance in those cancer cell lines proficient in Atase expression. Novel O6-substituted guanine analogues have been synthesized, bearing acidic, basic and hydrogen bonding functional groups. In contrast to existing O6-modified purine analogues, such as methyl or benzyl, the new compounds were found to resist repair by Atase even when tested at concentrations much higher than O6-benzylguanine, a wel

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32

Carraro, Maria Letícia. "Chiral derivatives of xanthones: synthesis, enantiomeric purity and effect on human tumor cell lines." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/89024.

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Carraro, Maria Letícia. "Chiral derivatives of xanthones: synthesis, enantiomeric purity and effect on human tumor cell lines." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/89024.

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34

Liang, Ming-Jen, and 梁明仁. "Application of Steroid Derivatized Fluorescent Probes and Gold Nanoparticles to Label and Purify Corresponding Binding Proteins." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/00111849819300130197.

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碩士<br>國立臺灣大學<br>化學研究所<br>93<br>The aims of this thesis are to synthesize fluorescent steroid derivatives, which can be used to label the corresponding steroid binding protein and estrogen receptor in vivo, and to fabricate pregnenolone-capped gold nanoparticles for further purifying the pregnenolone binding protein. It was shown that pregnenolone can help stabilize the structure of microtubules in zebrafish embryo and affects the cell movement. Presumably there might be pregnenolone binding protein, which can control the formation of microtubules in zebrafish embryo. Motivated by this obse

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35

Hung, Li-Tai, and 洪立泰. "Development of Gold Nanoparticles Capped with Benzene Sulfonamide Derivatives to Label and Purify Bovine Carbonic Anhydrase II Towards the Application in Proteomics." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/22770177203173773578.

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碩士<br>國立臺灣大學<br>化學研究所<br>93<br>The completion of Human Genome Project heralded the beginning of the proteome era. We are urged to develop new technology which shows the potential toward proteomics. By introducing the frontier nano- technology, traditional inhibitor design of targeting enzyme has provided a novel platform for facilitating labeling and purification of protein with high biocomplexity. Benzene Sulfonamide, a general type of carbonic anhydrase inhibitor combined with both a reactive epoxy group for affinity enhancement on labeling proteins and a thiol tail for anchoring on the gol

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Chen, Chun-Han, and 陳君涵. "A study on determination of the purity and degree of acetylation of chitinous products based on dye-binding and UV first derivative method." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/64383874117727012972.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>92<br>Abstract The applications of chitin are quite extensive nowdays. Researchers need to know the purity and the degree of acetylation of the raw materials before utilizing them. There are many methods to determine the degree of acetylation of chitn and chitosan at present, but none of them are flawless. The objectives of this study are to seek the possibile application of the first derivative UV spectroscopy on determining the degree of acetylation, to design a dye-binding method for purity determination, and to establish a new method by using 13C-NMR spectroscop

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