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Journal articles on the topic 'PVP K-30'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dharmendra, Kumar. "Domperidone Nasal Gel Using Fenugreek Seed as Mucoadhesive Agent: Water Solubility Problem Sort-Out." Trends in Pharmaceuticals and Nanotechnology 2, no. 1 (2019): 1–11. https://doi.org/10.5281/zenodo.3477840.

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<strong><em>Objective</em></strong><em>: </em><em>The aim of this research work was to develop a mucoadhesive nasal gel of domperidone in an aqueous medium. Mixed solvency concept was used to enhance the aqueous solubility of Domperidone. <strong>Methods</strong>: The study was facilitated by collecting fenugreek seeds and subjected to hydro extraction. Mixed solvency concept was used to improve aqueous solubility of domperidone.<strong> Results</strong>: Mucoadhesive agent was extracted from fenugreek seeds by simple hydro extraction. Solubility of domperidone was enhanced by using sodium cit

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2

Kumala Sari, Lusia Oktora Ruma, Kuni Zu’aimah Barikah, and Via Rahmatia. "OPTIMASI CROSPOVIDONE DAN POLYVINYL PYRROLIDONE K-30 DALAM FORMULASI ORALLY DISINTEGRATING TABLET (ODT) SALBUTAMOL SULFAT." Jurnal Kesehatan Islam : Islamic Health Journal 12, no. 1 (2023): 25–32. http://dx.doi.org/10.33474/jki.v12i1.19900.

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Abstract. The objective of the present study was to optimize crospovidone as a superdisintegrant and polyvinyl pyrrolidone (PVP) K-30 as a binder in ODT salbutamol sulphate. ODT salbutamol sulphate was made by direct compression technique. Optimization was carried out by the factorial design method using Design Expert 11.0 software with optimized responses, including hardness, friability, and disintegration time. The result showed that crospovidone affected the decrease in the disintegration time of ODT. PVP K-30 affected decreasing friability and increasing hardness and disintegration time of

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Fatmawati, Dina Ayu, Bambang Widjaja, and Dwi Setyawan. "Optimasi Tablet Levofloksasin yang Mengandung Bahan Pengikat PVP K-30 dan Disintegran Vivasol." Jurnal Sains Farmasi & Klinis 4, no. 1 (2017): 9. http://dx.doi.org/10.29208/jsfk.2017.4.1.155.

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Penelitian ini bertujuan mendapatkan formula yang optimal tablet levofloksasin yang dibuat dengan variasi PVP K-30 sebagai pengikat dan vivasol sebagai disintegran. Metode pembuatan tablet levofloksasin dilakukan secara granulasi basah. Formula tablet dibuat dengan variasi PVP K-30 dan disintegran vivasol, dikempa menggunakan alat hidrolik press dengan puch diameter 12 mm, selama 3 detik. Evaluasi mutu fisik (kekerasan, kerapuhan, dan waktu hancur) dan laju disolusi tablet. Optimasi formula dilakukan dengan desain faktorial 22 yaitu eksperimen faktorial dengan 2 faktor (PVP K-30 dan vivasol) d

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Lusiana, Retno Ariadi, Riska Nurfida Annisa, Vinsencius Guntur Pandu Marcellino, Didik Setiyo Widodo, and Hasan Muhtar. "Fabrication and Characterization of Chitosan-Polyvinyl Pyrolidone K-30 for Creatinine Transport Membranes." Jurnal Kimia Sains dan Aplikasi 26, no. 10 (2023): 381–90. http://dx.doi.org/10.14710/jksa.26.10.381-390.

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The investigation of membrane-based hemodialysis is an interesting study due to its efficacy in eliminating metabolic waste compounds, such as creatinine, from the body. However, not all membrane types exhibit optimal transport capabilities, necessitating modifications. In this study, we conducted modifications on chitosan (CS) membranes by incorporating polyvinyl pyrrolidone K-30 (PVP K-30) and assessing their physicochemical characteristics. The modified membrane underwent characterization and subsequent evaluation of its transport capabilities. The primary objective of this research is to d

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5

Sadiarti, Asri Prahmanita, Endang Diyah Ikasari, and A. Ariani Hesti W.S. "PENINGKATAN DISOLUSI NIFEDIPIN DENGAN PELARUT PVP K-30 MENGGUNAKAN METODE DISPERSI PADAT." Jurnal Ilmu Farmasi dan Farmasi Klinik 19, no. 1 (2022): 24. http://dx.doi.org/10.31942/jiffk.v19i1.6680.

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ABSTRACTNifedipine is an anti-hypertensive included in the Biopharmaceutics Classification System (BCS) class II to its nature of being poorly soluble in water, resulting in low bioavailability. One technique that can be used to improve the solubility of the dispersion technique. This research aimed to determine the effect of the concentration of PVP K-30 on physical characteristics, the dissolution rate of solid dispersions, and the interactions that occur between nifedipine with PVP K-30. The method of manufacturing solid dispersion is a melting-solvent method. FI - F III is a solid dispersi

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Sudhir, M., M. Manjusha, R. R. Manjula, N. Jyothi, and N. Lakshmi Prasanthi. "PREPARATION AND EVALUATION OF IBUPROFEN LIQUID FILL FORMULATIONS FOR SOFT GELS." INDIAN DRUGS 54, no. 12 (2017): 65–68. http://dx.doi.org/10.53879/id.54.12.10873.

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The present investigation was undertaken with an objective to prepare and evaluate liquid fill formulations of non-steroidal anti-inflammatory drug, ibuprofen (IBU), in order to improve its dissolution properties and thereby its bioavailability. Liquid fill formulations were prepared by employing different co-solvents and surfactants like polyethylene glycol 400 (PEG 400), propylene glycol (PG) and polyvinylpyrrolidone (PVP K-30). The liquid fills were characterized by assay, rheology, clarity, in vitro dissolution studies and FTIR. More than 90% of the drug was released within 5 min from PVP

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Bhumi, Patel* Dr. Chainesh Shah. "FABRICATION AND IN-VITRO CHARACTERIZATION OF TRANSDERMAL MATRIX PATCH OF KETOPROFEN FOR TRANSDERMAL THERAPEUTIC SYSTEM." Indo American Journal of Pharmaceutical Sciences (IAJPS) 03, no. 09 (2016): 960–73. https://doi.org/10.5281/zenodo.153859.

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Objective: The objective of research work was to improve the permeability of Ketoprofen and to provide controlled release of drug to provide maximum effective concentration. Experimental work: Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human skin. Matrix type transdermal patches containing Ketoprofen were prepared by solvent casting method employing aluminium foil method. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide (DMSO) was used as penetration enhanc

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8

Nair, Bindu. "Final Report On the Safety Assessment of Polyvinylpyrrolidone (PVP)." International Journal of Toxicology 17, no. 4_suppl (1998): 95–130. http://dx.doi.org/10.1177/109158189801700408.

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Polyvinylpyrrolidone (PVP) is a linear polymer of 1-vinyl-2-pyrrolidone monomers used as a binder, emulsion stabilizer, film former, hair fixative, and suspending agent-nonsurfactant. The molecular weight of the polymer ranges from 10,000 to 700,000. PVP K-30, with an average molecular weight of 40,000, is typically used in cosmetic formulations. The highest concentration reported to be used is 35%. There was no significant absorption of PVP K-30 given orally to rats, and the acute oral LD50 was >100 g/kg for rats and guinea pigs. Neither toxic effects nor gross lesions were found in rats m

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9

Gayo, Zahara, Henny Lucida, and Erizal Zaini. "Solid dispersion of quercetin-PVP K-30 and its effects on the antioxidant activity." Jurnal Ilmiah Farmasi 16, no. 2 (2020): 144–54. http://dx.doi.org/10.20885/jif.vol16.iss2.art6.

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Background: Quercetin (3,3’,4’,5,7-pentahydroxil-flavon) is a flavone and secondary metabolite known as flavonoid. Quercetin belongs to class II BCS that has low solubility and high permeability. The poor solubility of quercetin restricts the accessibility and bioavailability. Objectives: To increase the solubility, dissolution, and antioxidant activity in a solid dispersion system. Methods: Preparation of quersetin-PVP K-30 solid dispersion was conducted using the freeze-drying method at -96 degree C for 24 hours with a ratio of 1:1, 1:0.5, and 0.5:1 and a 1:1 physical mixture of quercetin-PV

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10

Maulana, Riza, Henry Harto, and Tiara Dewi Salindri Pratama. "Formulation of Nifedipine–Polyvinyl Pyrrolidone (PVP) Solid Dispersion System and Intrinsic Dissolution Rate Evaluation." Pharmacon: Jurnal Farmasi Indonesia 19, no. 2 (2022): 108–14. http://dx.doi.org/10.23917/pharmacon.v19i2.20545.

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Nifedipine is a drug that acts as an antihypertensive and anti-angina. Nifedipine is known as a drug with poor water solubility. This characteristic will affect the intrinsic dissolution rate so that it can affect the absorption process and reduce the amount of drug that reaches systemic circulation. One of the strategies to increase the intrinsic dissolution rate is developing nifedipine to solid dispersions form. This study aims to observe the intrinsic dissolution rate of nifedipine after it has been made into a solid dispersion. Four samples were prepared, including three solid dispersions

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11

Vyas, Tejas. "Development and evaluation of therapeutically useful oral solid tablets containing natural extracts: a quality by design approach." Journal of Medical pharmaceutical and allied sciences 13, no. 2 (2024): 6449–58. http://dx.doi.org/10.55522/jmpas.v13i2.6023.

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The quality target product profile was created for therapeutically useful oral solid tablets containing natural extracts. Important quality criteria were recognised. The risk priority no. was used to evaluate critical materials for initial risk assessment. Using Central Composite Design, the effects of critical parameters (croscarmellose sodium & PVP K-30) were investigated. The impact of the formulation variables X1: Croscarmellose sodium and X2: PVP K-30 on responses Y1: DT (Disintegration time in minutes) and Y2: Friability (%) were assessed. Factor X2: PVP K-30 was found to have a subs

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12

Khasanah, Khuswatun, Desy Nawangsari, and Ikhwan Yuda Kusuma. "Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method." Indo. J. Chem. Res. 10, no. 3 (2023): 183–94. http://dx.doi.org/10.30598//ijcr.2023.10-kha.

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Acetosal is classified in the Biopharmaceutical Classification System (BCS) class II (low solubility, high permeability). Low solubility causes a decreased dissolution rate. Polyvinyl pyrrolidone (PVP) K-30 is an inert carrier easily soluble in water and can influence the solubility of a drug substance. Efforts to increase the solubility of acetosal make a solid dispersion system. This study aims to determine the effect of the solid dispersion system of acetosal: PVP K-30 on dissolution rate, the ratio of the solid dispersion with the best dissolution rate, and the physical properties of aceto

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13

Febriyenti, Febriyenti, Peki Indra, Erizal Zaini, Friardi Ismed, and Henny Lucida. "Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion." Journal of Pharmacy & Pharmacognosy Research 8, no. 1 (2020): 127–34. http://dx.doi.org/10.56499/jppres19.729_8.2.127.

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Context: The use of quercetin as a potential active pharmaceutical ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried solid dispersion technique is used to increase the solubility and dissolution profiles of quercetin. Aims: To prepare and characterize quercetin solid dispersion using polyvinylpyrrolidone (PVP) K-30. Methods: Solid dispersions (SDs) were prepared by spray drying technique at quercetin/PVP K-30 ratios of 10/90, 20/80, 30/70, 40/60 and 50/50. A physical mixture of quercetin/PVP K-30 (50/50) and pure quercetin were used as comparisons. T

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14

Rahaman, Tamanna, Jannatul Fardous, Faria Farzana Perveen, and Sakina Sultana. "Capacity of Non Ionic and Ionic Surfactants for Solubilisation of Paracetamol." Bangladesh Pharmaceutical Journal 16, no. 1 (2013): 77–80. http://dx.doi.org/10.3329/bpj.v16i1.14498.

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The present study was conducted to investigate the solubilising capacity of polyvinylpyrrollidone (PVP K-30), Polyethylene glycol (PEG 6000), Polysorbate (Tween 80) and Sodium lauryl sulphate (SLS) for paracetamol. In our study, PVP K-30 exhibited 5 times, Tween 80 showed 3 times and SLS displayed 2 times higher solubilising capacity than water. Here, PVP K-30 exhibited the highest solubilising capacity and the value was 6.36 ± 0.063 (mg /ml), whilst PEG 6000 in the same study failed to show any significant increase (p> 0.05, unpaired t-test, two-tailed). DOI: http://dx.doi.org/10.3329/bpj.

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15

Lusiana, Retno Ariadi, Rahmad Nuryanto, Nor Basid Adiwibawa Prasetya, Resa Putri Sherina, and Dilla Dayanti. "Eco-Friendly Chitosan-Based Biodiesel Heterogeneous Catalyst Support Membrane." Jurnal Kimia Sains dan Aplikasi 26, no. 2 (2023): 39–49. http://dx.doi.org/10.14710/jksa.26.2.39-49.

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A chitosan-polyvinyl pyrrolidone K-30 (Cs-PVP.K30) membrane was prepared as a heterogeneous catalyst supporting membrane in the transesterification process in the production of biodiesel from palm oil and methanol through the blend reaction between chitosan (Cs) and polyvinyl pyrrolidone K-30 polymer (PVP K-30). Several membranes were characterized by their physicochemical and catalytic properties. Based on physicochemical data, it was found that including the carbonyl group from PVP K-30 into the chitosan framework correlated with an increase in porosity, hydrophilicity, water absorption, and

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16

Budipratiwi Wisudyaningsih, Lusia Oktora Kumala Sari, and Tiara Puspita Arisanti. "OPTIMASI SODIUM STARCH GLYCOLATE DAN POLYVINYLPYRROLIDONE K-30 DALAM SEDIAAN ORALLY DISINTEGRATING TABLET SALBUTAMOL SULFAT." Jurnal Kesehatan Islam : Islamic Health Journal 12, no. 2 (2023): 19–27. http://dx.doi.org/10.33474/jki.v12i2.20838.

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ABSTRACT Difficulty in swallowing drug and slow onset of action of drug are common problems of conventional tablet. Orally disintegrating tablet (ODT) is an innovative dosage form to overcome the problem of swallowing drug and provide quick onset of action of drug because it can disintegrates quickly when contact with saliva in less than 3 minutes. This study formulate and evaluate ODT containing salbutamol sulphate to relieve the respiratory disorders immediately. Materials that affect the disintegration time of ODT are superdisintegrants and binders. Sodium Starch Glycolate (SSG) is a superd

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17

Aisiyah, Siti, Achmad Fudholi, and Abdul Rohman. "Optimasi Formula Tablet Floating Nifedipin Menggunakan HPMC K15M, PVP K-30 dan Avicel PH 102 dengan Metode Simplex Lattice Design." Jurnal Farmasi (Journal of Pharmacy) 2, no. 1 (2019): 30. http://dx.doi.org/10.37013/jf.v2i1.17.

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Nifedipin merupakan obat dengan kelarutan kecil dalam air sehingga kelarutan nifedipin perlu ditingkatkan dengan penambahan PVP K-30. Penelitian ini bertujuan untuk mengetahui pengaruh HPMC K15M, PVP K-30 terhadap pelepasan nifedipin, dan Avicel PH 102 terhadap floating lag time tablet floating nifedipin, serta untuk mengetahui proporsi masing-masing bahan untuk membuat formula optimum tablet floating nifedipin. Penelitian dilakukan dengan metode simplex lattice design (SLD) dengan 3 komponen yaitu HPMC K15M, PVP K-30 dan Avicel PH 102 sehingga diperoleh 14 formula. Parameter optimasi terdiri

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Dornelas, Camila B., Luciano A. M. Grillo, Irinaldo D. B. Junior, et al. "Estudo do processo de intercalação via solução PVP-bentonita: a avaliação da influência do tempo reacional, da proporção de polímero-argila e da massa molar média." Polímeros 20, no. 4 (2010): 275–79. http://dx.doi.org/10.1590/s0104-14282010005000047.

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Foram produzidas reações, via solução, PVP-bentonita (natural e organicamente modificada) nas quais foi estudada a influência das variáveis: tempo reacional (15, 30, 45 minutos, 1, 24, 48, 72 horas), proporção polímero-argila (2:1, 1:1, 1:2) e massa molar média (PVP K-30, PVP K-90). Com o auxílio de técnicas de difração de raios X (XRD), infravermelho com transformada de Fourier (FTIR) e análise termogravimétrica (TGA) foi possível não somente elucidar a formação de nanocompósitos intercalados como também o seu processo reacional.

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Zaini, Erizal, Vike Zulia Putri, Maria Dona Octavia, and Friardi Ismed. "Peningkatan Laju Disolusi Dispersi Padat Amorf Genistein dengan PVP K-30." Jurnal Sains Farmasi & Klinis 4, no. 1 (2017): 67. http://dx.doi.org/10.29208/jsfk.2017.4.1.197.

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Sistem dispersi padat amorf senyawa obat yang sukar larut air genistein dalam PVP K-30 dibuat dengan metode penguapan pelarut menggunakan pelarut metanol. Sistem dispersi padat dibuat dengan variasi perbandingan obat : polimer 2:1, 1:1 dan 1:2 b/b. Sifat padatan serbuk sistem dispersi padat dievaluasi dengan metode analisa difraksi sinar-X, termal DSC, spektrokopik FT-IR dan mikroskopik SEM. Profil disolusi dilakukan dalam medium air suling dengan alat uji disolusi tipe II USP. Hasil analisa difraksi sinar-X, termal DSC dan mikroskopik SEM, fase kristalin genistein mengalami penurunan derajat

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Saryanti, Dwi, and Fatma Eka Saputri. "FORMULATION OF TABLETS OF LONGAN (Euphoria Longana Lam) LEAVE EXTRACT WITH VARIATIONS OF POLYVYNY PIROLIDONE (PVP K-30) AS BINDER." JKPharm Jurnal Kesehatan Farmasi 4, no. 1 (2022): 17–23. http://dx.doi.org/10.36086/jpharm.v4i1.1231.

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Background: Longan leaf (Euphoria longana Lam) is one of the plants that can be used by the community as an antipyretic or fever reducer with phytochemical content of saponins, flavonoids, triterpenoids and steroids, tannins, and glycosides. The tablet preparation was chosen in the formulation because it has an accurate dosage per tablet or per unit of use. This study aims to determine the concentration of PVP K-30 can produce tablet preparations from longan leaf extract as a binder that has good physical stability.Methods: Longan leaf extract was obtained by extraction by maceration method us

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Dornelas, Camila Braga, Alex Moura Silva, Cide Brizio Dantas, et al. "Preparation and Evaluation of a New Nano Pharmaceutical Excipients and drug Delivery System Based in Polyvinylpyrrolidone and Silicates." Journal of Pharmacy & Pharmaceutical Sciences 14, no. 1 (2011): 17. http://dx.doi.org/10.18433/j3hc72.

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PURPOSE: This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate. METHODS: By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality and toxicity were also tested. The AAM/PVP K-30 and AAM/GME nanocomposite obtained were evaluated to identify the interlamellar spacing values by XRD diffratograms. Tablets were prepared using methyldopa and theophylline as model drugs and the dissolution tests were carried out

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Sui, Xiaoyu, Yan Chu, Jie Zhang, et al. "The Effect of PVP Molecular Weight on Dissolution Behavior and Physicochemical Characterization of Glycyrrhetinic Acid Solid Dispersions." Advances in Polymer Technology 2020 (October 30, 2020): 1–13. http://dx.doi.org/10.1155/2020/8859658.

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The effect of polyvinylpyrrolidone (PVP) as glycyrrhetic acid (GA) solid dispersions carrier at different molecular weights on the dissolution behavior and physicochemical properties was investigated. PVP-GA-SDs prepared with all four molecular weight PVPs displayed good enhancement of dissolution rate and equilibrium solubility compared with pure drug and corresponding physical mixtures. The results showed that the enhancement effect of molecular weight on dissolution rate and equilibrium solubility follows PVP K 30 > PVP K 60 > PVP K 17 > PVP K 15 . In addition, the dissolution rate

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Arifin, Arfiani, Sartini Sartini, and Marianti Marianti. "Evaluasi Karakteristik Fisik dan Uji Permeasi Pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon." Jurnal Sains dan Kesehatan 2, no. 1 (2019): 40–49. http://dx.doi.org/10.25026/jsk.v2i1.103.

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Penelitian ini bertujuan mengetahui kombinasi perbandingan polimer etilselulosa dan PVP K-30 yang menghasilkan karakteristik fisik baik dan pengaruhnya terhadap permeasi kulit pada hewan coba. Pengujian yang dilakukan meliputi pengujian fisik yaitu uji organoleptik, kadar air, ketebalan, dan keseragaman bobot, serta uji permeasi kulit pada hewan coba menggunakan membran kulit tikus dan kelinci. Perbandingan formulasi etilselulosa dan PVP K-30 yang digunakan adalah 7:3 (F1), 8:2 (F2) dan 9:1 (F3). Patch dibuat dengan menggunakan metode solvent casting atau dikenal metode cetak tuang. Hasil pene

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Pramesti, Ni Kadek Ayu, I. Putu Mas Arie Pradina Putri, Ni Putu Mas Arya Shinta, and I. Gusti Ngurah Jemmy Anton Prasetia. "Optimasi Formula Patch Transdermal Ekstrak Etanol Daun Seledri untuk Pengobatan Hipertensi." Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI) 8, no. 1 (2021): 71–79. http://dx.doi.org/10.48177/bimfi.v8i1.37.

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Pendahuluan: Hipertensi merupakan salah satu masalah kesehatan terbesar bagi masyarakat Indonesia. Daun seledri merupakan salah satu tanaman yang dapat digunakan untuk mengobati penyakit hipertensi. Penelitian menunjukan bahwa ekstrak etanol daun seledri dengan dosis 150 mg/hari dapat menurunkan tekanan darah. Obat antihipertensi memiliki bioavailabilitas oral yang rendah karena mengalami first pass metabolism di hati. Penggunaan patch transdermal dapat meningkatkan kenyamanan pasien dan dapat memperbaiki biaovaibilitas oral yang rendah. Salah satu komponen penting dalam sediaan patch adalah m

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Soraya, M., H. Laksono, H. Purwoto, et al. "Optimizing Seaweed Capsule Shell Formula with Multiple Disintegrants to Accelerate Disintegration Time." IOP Conference Series: Earth and Environmental Science 1358, no. 1 (2024): 012001. http://dx.doi.org/10.1088/1755-1315/1358/1/012001.

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Abstract Seaweed-based capsule shells are gaining popularity due to their animal-free sourcing and guaranteed quality. However, these shells often suffer from prolonged disintegration. Various studies have explored formulations with additional disintegrants like polyvinylpyrrolidone (PVP) K-30, yet results have fallen short of pharmacopeia standards. In this research, multiple disintegrants and formulations were tested to develop seaweed capsule shells with rapid disintegration times. The variation in composition of disintegrants was determined using Simplex Lattice Design (SLD) in Design Expe

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Dipahayu, Damaranie, and Irma Adinda Safira. "Aktivitas Antioksidan Sediaan Nutraceutical Tablet Hisap Ekstrak Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3." Borneo Journal of Pharmascientech 9, no. 1 (2025): 29–34. https://doi.org/10.59053/bjp.v9i1.543.

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Ekstrak daun ubi jalar ungu Ipomoea batatas L vareitas Antin-3 (EDA3) dapat dijadikan sumber antioksidan alami karena kandungan flavonoid dan polifenol yang tinggi. Penelitian ini bertujuan untuk mencari pengaruh variasi komponen pengikat terhadap aktivitas antioksidan dari sediaan nutraseutikal tablet hisap EDA3. Bahan pengikat yang digunakan yaitu PVP K-30 pada konsentrasi 5 % dan 10 % (F1; F2), kedua sampel akan dilihat aktivitas antioksidannya dengan metode DPPH. Dari hasil penelitian, ekstrak memperoleh rata-rata nilai IC50 pada F1 sebesar 24.1 ± 0,8 ppm; F2 sebesar 63,4 ± 2,0 ppm dan vit

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P, Kumar, S. Kumar, A. Kumar, and M. Chander. "Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 2 (2010): 948–56. http://dx.doi.org/10.37285/ijpsn.2010.3.2.8.

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The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the t

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Soraya, M., R. P. G. Putri, H. Purwoto, et al. "Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant." IOP Conference Series: Earth and Environmental Science 1377, no. 1 (2024): 012003. http://dx.doi.org/10.1088/1755-1315/1377/1/012003.

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Abstract Recently, seaweed-based capsule shells have become more popular because of their reliable quality and animal-free source. But these shells’ prolonged disintegration times are a common problem. This research aims to look for formulations with disintegrant substitution or a combination of several disintegrants to obtain capsule shells that disintegrate quickly. Several studies have explored the incorporation of additional disintegrants such as Polyvinylpyrrolidone (PVP) K-30, Sodium starch glycolate (primogel), Croscarmellose sodium (SSC), and Sodium carboxymethylcellulose (Na-CMC) to a

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Dornelas, Camila B., Daniel K. Resende, Maria Inês B. Tavares, Ailton S. Gomes, and Lúcio M. Cabral. "Preparação e avaliação reacional de nanocompósitos de PVP K-30 - montmorilonita (natural e organicamente modificada) por difração de raios X." Polímeros 18, no. 2 (2008): 187–92. http://dx.doi.org/10.1590/s0104-14282008000200017.

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Em estudo anterior foi utilizado o conceito de nanocompósito para aplicações farmacêuticas, mais especificamente na liberação controlada de fármacos. Um nanocompósito polímero (PVP K-30) - silicato lamelar (argila organofílica, OMMT) foi preparado por solução, em diclorometano, e a sua avaliação como excipiente farmacêutico foi realizada com sucesso. Neste trabalho, um estudo do tempo reacional foi realizado (12, 48 e 72 horas), tendo sido observado, através de difração de raios X (DRX), um valor de espaçamento interlamelar máximo em 12 horas. Este resultado motivou um estudo mais detalhado a

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Gupta, V. Rama Mohan, Srikanth K, Sree Giri Prasad, B, G. Naveen Kumar Reddy, and Sudheer B. "Formulation and Evaluation of Directly Compressible Agglomerates of Celecoxib." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 4 (2011): 1193–204. http://dx.doi.org/10.37285/ijpsn.2010.3.4.4.

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Prepared spherical crystals of Celecoxib to increase the compressible properties, dissolution rate and bioavailability, using hydrophilic polymers such as PEG-4000, sod.CMC, sod.alginate and PVP K-30. All the formulations were characterized for micromeritic properties, Drug loading, solubility, in vitro drug release and mean dissolutiom time (MDT). New formulations showed higher dissolution rates and less MDT values than the pure celecoxib. Among all, the crystals prepared with 10 % w/v PVP K-30 exhibited maximum dissolution rate (2.95±0.23%) and very less MDT values (18.50 ± 4.01 min). Hence

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Nurhikmah, Wilda, Erni Rustiani, and Dania Triska Puspita. "PENGEMBANGAN SEDIAAN TABLET ESTROGENIK DARI EKSTRAK RUMPUT KEBAR (Biophytum petersianum) MENGGUNAKAN VARIASI KONSENTRASI PENGIKAT PVP K-30." Jurnal Ilmiah Manuntung 9, no. 2 (2023): 111–19. http://dx.doi.org/10.51352/jim.v9i2.661.

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Kebar grass (Biophytum petersianum Klotzsch) contains steroid, saponins, flavonoids, alkaloids, and triterpenoids. The use of Kebar grass extract can increase the development of follicles because it contains saponins which are the basic ingredients for the synthesis of steroid hormones and can improve the performance of reproductive system. This study aims to determine the quality the tablets made from Kebar grass extract with varying concentrations of PVP K-30 binder. Tablets were made in 3 formulas with varying concentrations of PVP K-30 as a binder, namely 2% (F1), 3% (F2), and 4% (F3). Met

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Turnip, Monika Maristella, Sunarti Sunarti, and Desy Nawangsari. "Evaluation of the physical properties of andaliman (Zanthoxylum acanthopodium DC) fruit extract tablets using polyvinylpyrrolidone as a binder agent." Acta Pharmaciae Indonesia : Acta Pharm Indo 11, no. 1 (2024): 6900. http://dx.doi.org/10.20884/1.api.2023.11.1.6900.

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Background: Zanthoxylum acanthopodium DC, also known as andaliman, is a traditional herb utilized predominantly as a spice. It is rich in bioactive compounds such as alkaloids, flavonoids, tannins, saponins, and terpenoids, which exhibit analgesic activities. Objective: This study aims to develop a tablet formulation of andaliman fruit extract, employing polyvinyl pyrrolidone (PVP) K-30 as a binder, utilizing the wet granulation method. Method: The andaliman fruit was processed to extract its components using 96% ethanol. The extract, at a concentration of 100 mg, was then formulat

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Kan, Caixia, Weiping Cai, Cuncheng Li, and Lide Zhang. "Optical studies of polyvinylpyrrolidone reduction effect on free and complex metal ions." Journal of Materials Research 20, no. 2 (2005): 320–24. http://dx.doi.org/10.1557/jmr.2005.0039.

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Polyvinylpyrrolidone (PVP) reduction effect on free and complex Ag+ and Au3+ ions was studied from optical measurements by adding a metal precursor (K-30), commonly used as a stabilizer, to PVP. It was found that PVP has a strong reduction effect on free ionic metal, such as Ag+ ion in AgNO3, but much weaker on complex ionic metals, AuCl4− in HAuCl4 and Ag(NH3)2+ in Ag(NH3)2OH. This is explained based on the coordinative field of polar group in PVP molecules.

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Sanaboina, Jyothi, K. M. Maheswari, Seetha Sunkara, Sravanthi Deekonda, and Buchi N. Nalluri. "Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels." Journal of Pharmaceutics 2013 (January 17, 2013): 1–8. http://dx.doi.org/10.1155/2013/418346.

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The present investigation includes the preparation of liquid filling formulations for soft gels using an antihypertensive drug, valsartan (VAL), in order to improve its dissolution properties and thereby its bioavailability. Formulations were prepared using excipients like polyethylene glycol 400 (PEG 400), propylene glycol (PG), polyvinylpyrrolidone (PVP K-30), antioxidants, ethanol, and purified water. Prepared formulations were evaluated for appearance, pH, drug content percentage, viscosity, stability, and in vitro dissolution studies. The compatibility between the drug and excipients in f

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Rustiani, Erni, Dwi Indriati, and Linda Actia. "FORMULASI TABLET HISAP CAMPURAN KATEKIN GAMBIR DAN JAHE DENGAN JENIS PENGIKAT PVP DAN GOM ARAB." Jurnal Fitofarmaka Indonesia 6, no. 1 (2019): 334–39. http://dx.doi.org/10.33096/jffi.v6i1.465.

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Gambir mempunyai kemampuan dapat membunuh ataupun menghambat pertumbuhan bakteri. Jahe memiliki kandungan flavonoid dan gingerol yang mempunyai aktivitas antibakteri untuk mulut dan gusi. Penelitian ini bertujuan untuk membuat sediaan tablet hisap kombinasi katekin gambir dan jahe dengan variasi jenis pengikat PVP dan Gom arab. Hasil penelitian menunjukkan bahwa formula terbaik dari setiap jenis pengikat yaitu formula dengan pengikat gom arab 10% dan formula dengan pengikat PVP K-30 7%. Berdasarkan kemudahan dalam proses granulasi dipilih formula dengan konsentrasi PVP K-30 7% sebagai formula

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Yashaswini, H. N., T. Bhagawati S, and Manjunath K. "Formulation and Evaluation of Fast Dissolving Buccal Films Containing Bambuterol HCL." International Journal of Current Science Research and Review 07, no. 05 (2024): 2818–33. https://doi.org/10.5281/zenodo.11207080.

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Abstract : The main objective of this research work is to formulate fast dissolving films to improve the patient compliance and bioavailability of Bambuterol HCl. Bambuterol HCl undergo first-pass metabolism, the development of fast dissolving buccal films of Bambuterol HCl release the drug in the buccal cavity and absorb through the buccal region. Hence first-pass metabolism of the drug could be avoided by developing into a fast-dissolving film of Bambuterol HCl. Fast dissolving Buccal films were prepared by solvent casting method using various polymers like HPMC E15, PVP K30, PVA and PEG600

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Panov, D. "SYNTHESIS OF SELENIUM NANOPARTICLES STABILIZED WITH POLYVINYLPYRROLIDONE." Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry 10, no. 3 (2024): 323–33. https://doi.org/10.29039/2413-1725-2024-10-3-323-333.

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In recent years, there has been an increase in publications devoted to the creation of new materials based on self-organized nanostructured composites of specified sizes and maintaining their stability for a long time. Nanosystems based on nanoselenium are of particular interest, as it is vital for humans and animals. However, in many regions of Russia, selenium deficiency is observed in agricultural soils. The least toxic and bioavailable is nanoscale selenium. Currently, the most widely used methods of chemical reduction of selenium ions in solutions using ascorbic acid, glucose, dithiourea

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Minhas, Muhammad Usman, Kifayat Ullah Khan, Muhammad Sarfraz, et al. "Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement." BioMed Research International 2022 (August 26, 2022): 1–15. http://dx.doi.org/10.1155/2022/5883239.

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Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately dosage increase. Current study is aimed at developing a polyvinylpyrrolidone- (PVP-K30-) based nanogel delivery system for solubility enhancement of poorly soluble drug olanzapine (OLP), as solubilization enhancement is the most noteworthy application of nanosystems. Crosslinking polymerization with subsequent condensation technique was used for the synthesis of nanogels, a hi

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Bayoumi, Asmaa A. ""Enhancement of solubility of a poorly soluble antiplatelet aggregation drug by cogrinding technique"." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (2018): 340. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.27136.

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Objective: The goal of this study was to formulate ticagrelor tablets with enhanced dissolution rate using cogrinding technique. However, it belongs to the biopharmaceutical classification system Class IV molecule, poorly soluble, and permeable.Methods: Various ratios (0.2:1–1.67:1) of povidone (PVP)/drug were used in the formulations. Ticagrelor was coground with different percentage of PVP K 25 (carrier) in a mortar with a pestle for 30 min, then mixed with the rest excipients. A high-performance liquid chromatography stability indicating assay was developed to test the stability of ticagrel

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Qureshi, Aminabi, Umaima Shaikh, Mehrunnisa Shaikh, Wafa Parkar, Maria Lal, and Mirza Salman Baig. "Solid Dispersion Incorporated Indomethacin Oro- Dispersible Tablet." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 5 (2024): 7580–88. https://doi.org/10.37285/ijpsn.2024.17.5.4.

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Aim: This study aimed to enhance the dissolution profile of indomethacin by formulating oro-dispersible tablets, using the Solid Dispersion technique and PEG 6000 and PVP K-30 as carriers. Method: Solid Dispersion (SD) of indomethacin were prepared using the kneading method. Pre-compression studies include evaluating granules' density and flow properties, while post-compression studies assessed tablet properties such as hardness, friability, wetting time, dissolution, drug content and material interactions. Result: All pre- and post-compressional parameters were found within pre-determined lim

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Chauhan, N., A. Mittal, and U.K.Bajaj. "Development and Characterization of Mucoadhesive Film of Nitrendipine for Buccal Administration." International Journal of Nano Studies & Technology 2, no. 3 (2013): 23–28. https://doi.org/10.19070/2167-8685-130005.

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Mucoadhesive buccal patches containing nitrendipine were prepared using the solvent casting method. Chitosan was used as bio-adhesive polymer and different ratios of chitosan to PVP K-30 were used. The pre-formulation study using DSC revealed the compatibility of drug and polymer. Patches were evaluated for their physical characteristics like weight variation, drug content uniformity, folding endurance, surface pH, in vitro drug release, and in vitro buccal permeation study. Patches exhibited controlled release for a period of 8 h. The mechanism of drug release was found to be n

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Zhong, Shao Jin, Guang Fa Wang, Chun Lan Dai, et al. "Preparation, Characterization and Evaluation In Vitro of Naringenin-PVP K-30 Solid Dispersions." Advanced Materials Research 236-238 (May 2011): 2422–28. http://dx.doi.org/10.4028/www.scientific.net/amr.236-238.2422.

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Solid dispersions (SD) were prepared with naringenin and polyvinyl pyrrolidone k-30 (PVP k-30) by the solvent evaporation method with three drying methods (microwave-vacuum drying, MVD; and spray drying, SPD; vacuum drying, VD). The physical state was characterized by DSC, PXRD, SEM, and FT-IR. The results showed that the vitro dissolution rate and extent of naringenin was improved significantly by SD as compared with the pure drug and physical mixtures (PM). The results of FT-IR showed that naringenin is possibly interacted with PVP k-30 via intermolecular hydrogen bond, the results of DSC an

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Imtihani, Hilya Nur, Fitria Abbas Thalib, and Silfiana Nisa Permatasari. "Formulation and Evaluation of Solid Dispersion Chitosan Tablet from Whiteleg Shrimp (Litopenaeus vannamei) Using PVP K-30 As a Carriers." Borneo Journal of Pharmacy 4, no. 1 (2021): 16–21. http://dx.doi.org/10.33084/bjop.v4i1.1557.

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Whiteleg shrimp (Litopenaeus vannamei) on the market are processed or sold only to take part in the meat. The head, shell, and tail are thrown away without any prior processing. Underutilized waste causes environmental problems. An alternative to overcome this environmental disturbance phenomenon is to utilize shrimp shells containing chitin and subsequently transformed into chitosan that can be applied in various fields. Chitosan has poor solubility in water but high permeability, so to improve bioavailability is by making solid dispersions. Chitosan solid dispersion made by the solvent evapo

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Santoso, Rahmat, Ivan Andriansyah, and Mamay Maulana. "Formulasi Minuman Pelet Instan Untuk Kesehatan Dari Black Sapote (Diospyros nigra) Dengan Metode Ekstrusi Sferonisasi." IKRAITH-Teknologi 7, no. 1 (2022): 64–73. http://dx.doi.org/10.37817/ikraith-teknologi.v7i1.2322.

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Pembuatan pelet instan menggunakan metode ekstrusi sferonisasi merupakan salah satu metode yangumum dalam pembuatan pelet. Proses pembuatannya berupa proses ekstrusi agar sediaan menjadibentuk ekstrudat, proses sferonisasi pembuatan agar menjadi bentuk pelet, proses salut lapis tipisyang berfungsi agar pelet lebih terjaga kestabilan sediaannya dan tidak menghasilkan partikel yangbesar serta hasil uji memenuhi syarat dengan baik. Pelet instan daging buah black sapote dibuatmenjadi sediaan minuman kesehatan yang praktis dan kaya manfaat. Membuat minuman pelet instandari daging buah black sapote

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Kumar, Rahul, Sanjay Kumar, Pranava Chaudhari, and Amit K. Thakur. "Liquid antisolvent recrystallization and solid dispersion of flufenamic acid with polyvinylpyrrolidone K-30." International Journal of Chemical Reactor Engineering 19, no. 7 (2021): 663–71. http://dx.doi.org/10.1515/ijcre-2020-0168.

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Abstract Flufenamic acid (FFA) is a Biopharmaceutical Classification System- II (BCS-II) class drug with poor bioavailability and a lower dissolution rate. Particle size reduction is one of the conventional approaches to increase the dissolution rate and subsequently the bioavailability. The use of the liquid antisolvent method for particle size reduction of FFA was studied in this work. Ethanol and water were used as solvent and antisolvent, respectively. Experimental parameters such as solution concentration (10–40 mg/ml), flow rate (120–480 ml/h), temperature (298–328 K) and stirring speed

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Plisko, Tatiana V., Alexandr V. Bildyukevich, Liang Zhao, Weiqing Huang, Vladimir V. Volkov, and Zuohua Huang. "Formation of Polysulfone Hollow Fiber Membranes Using the Systems with Lower Critical Solution Temperature." Fibers 9, no. 5 (2021): 28. http://dx.doi.org/10.3390/fib9050028.

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This study deals with the investigation of the phase state of the polymer systems from polysulfone (PSF) with the addition of polyethylene glycol (PEG-400, Mn = 400 g·mol−1) and polyvinylpyrrolidone (PVP K-30, Mn = 40,000 g·mol−1) in N,N-dimethylacetamide (DMA), which feature lower critical solution temperatures (LCSTs). A fragment of the phase state diagram of the system PSF —PEG-400—PVP K-30—DMA was experimentally constructed in the following range of component concentrations: PSF 20–24 wt.%, PEG-400—35–38 wt.% and PVP—0–8 wt.%. It has been established that PVP addition substantially reduces

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Fadhila, Muthia, Rina Wahyuni, and Ayang Sasua Putri. "Optimization of Planetary Ball Mill Size on Physicochemical Properties and Dissolution Rate of Nimodipine- PVP K-30." International Journal of Research Publication and Reviews 03, no. 12 (2022): 732–37. http://dx.doi.org/10.55248/gengpi.2022.31213.

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Nimodipine is a compound that is insoluble in water and is included in the biopharmaceutical classification system (BCS) class II. This study looks at the characterization of nimodipine-PVP K-30 with the wet grinding method using a planetary ball mill at 200 rpm with large and small ball sizes. Nimodipine was made into 3 formulas, namely a physical mixture (1:0.6), formula 1 with 24 large balls (1:0.6), and formula 2 with 143 small balls (1:0.6). Evaluation of physicochemical properties includes size distribution, surface morphology, functional group analysis, crystallinity properties, thermal

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Liu, Dan, Yaxin Zhao, Zhuqing Yan, et al. "Screen-Printed Flexible Thermoelectric Device Based on Hybrid Silver Selenide/PVP Composite Films." Nanomaterials 11, no. 8 (2021): 2042. http://dx.doi.org/10.3390/nano11082042.

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In recent years, the preparation of flexible thermoelectric generators by screen printing has attracted wide attention due to easy processing and high-volume production. In this work, we propose an n-type Ag2Se/polymer polyvinylpyrrolidone (PVP) film based on screen printing and investigate the effect of PVP on thermoelectric performance by varying the ratio of PVP. When the content ratio of Ag2Se to PVP is 30:1, i.e., PI30, the fabricated PI30 film has the best thermoelectric property. The maximum power factor (PF) of the PI30 is 4.3 μW·m−1·K−2, and conductivity reaches 81% of its initial val

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Jeong, Hyun Ki, Jin Young Park, Su Young Kim, et al. "Dissolution Properties of Lercanidipine Solid Dispersion Manufactured Water – Soluble Polymer PVP K-30." Polymer Korea 40, no. 1 (2016): 33. http://dx.doi.org/10.7317/pk.2016.40.1.33.

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Bhatia, Meenakshi, and Sunita Devi. "Development, characterisation and evaluation of pvp k-30/peg solid dispersion containing ketoprofen." ACTA Pharmaceutica Sciencia 58, no. 1 (2020): 83. http://dx.doi.org/10.23893/1307-2080.aps.05806.

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