Relevant bibliographies by topics / Pyrimidmes

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Pyrimidmes'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Pyrimidmes"

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KRISHNA, C. JOSHI, N. PATHAK VIJAI, and GUPTA RAGINI. "Reactions of 2-(FIuoroaryl)-lH-indole-3- carboxaldehydes with Barbituric and Thiobarbituric Acids." Journal of Indian Chemical Society Vol. 67, May 1990 (1990): 434–35. https://doi.org/10.5281/zenodo.6280122.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004 Manuscript received 5 September 1988, revised 28 December 1989, accepted 1 January 1990 Reactions of 2-(Fluoroaryl)-lH-indole-3- carboxaldehydes with Barbituric and Thiobarbituric Acids     
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García-García, Ángela, Jesus Vicente de Julián-Ortiz, Jorge Gálvez, et al. "Similarity-Based Virtual Screening to Find Antituberculosis Agents Based on Novel Scaffolds: Design, Syntheses and Pharmacological Assays." International Journal of Molecular Sciences 23, no. 23 (2022): 15057. http://dx.doi.org/10.3390/ijms232315057.

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A method to identify molecular scaffolds potentially active against the Mycobacterium tuberculosis complex (MTBC) is developed. A set of structurally heterogeneous agents against MTBC was used to obtain a mathematical model based on topological descriptors. This model was statistically validated through a Leave-n-Out test. It successfully discriminated between active or inactive compounds over 86% in database sets. It was also useful to select new potential antituberculosis compounds in external databases. The selection of new substituted pyrimidines, pyrimidones and triazolo[1,5-a]pyrimidines
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Al-Azmi, Amal. "Novel 6-substituted Pyrimidines and Pyrimido[5,4-d]pyrimidines from (2-acetamido-1,2-dicyanovinyl)Ammonium Chloride." Journal of Chemical Research 2005, no. 8 (2005): 530–34. http://dx.doi.org/10.3184/030823405774663200.

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The reaction of triethyl orthoformate with 5-amino-6-ethoxy-2-methyl-4-pyrimidinecarbonitrile (5), available from DAMN via the ammonium salt 4, afforded iminoformate 6. The latter cyclised with aqueous ammonia or equimolar amounts of aryl/benzyl amines to give the corresponding pyrimido[5,4-d]pyrimidines 8, 9a–c. Reaction with excess of aqueous ethylamine, methylamine or benzylamine caused cyclisation with substitution of an ethoxy group to give 9d–f. Hydrolysis of compounds 8, 9a–b under acidic conditions gave the corresponding pyrimido[5,4-d]pyrimidones 10, 11a–b. Heating 4 to reflux in THF
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Uryadova, Anastasia, Elena Makarova, and Sergey Filimonov. "Diastereoselective synthesis of chromeno[4,3-d]pyrimidines." From Chemistry Towards Technology Step-By-Step 4, no. 2 (2023): 66–71. http://dx.doi.org/10.52957/2782-1900-2024-4-2-66-71.

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The paper investigates the diastereoselective synthesis of chromeno[4,3-d]pyrimidines by isolation and cyclization of diastereomerically pure dihydropyrimidine addition intermediates to resorcinol. The authors discovered the reversibility of the addition reaction to be an important factor that could neutralize the dominant formation of one of the intermediate diastereomers.
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Behera, Manoranjan, M. Sambaiah, Poosa Mallesham, et al. "Tandem Schiff-Base Formation/Heterocyclization: An Approach to the Synthesis of Fused Pyrazolo–Pyrimidine/Isoxazolo-Pyrimidine Hybrids." Synlett 30, no. 05 (2019): 586–92. http://dx.doi.org/10.1055/s-0037-1612081.

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A new synthesis of pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines is described. Key steps in the synthesis involve Stille coupling of 4,6-dichloro-2-phenyl-pyrimidine with tributyl(1-ethoxyvinyl)stannane and tandem Schiff-base formation/heterocyclization of 2,6-di-aryl-5-fluoro-4-acetylpyrimidine with hydrazines or ­hydroxylamine to give pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines, respectively. The position of the fluoro group in the ­pyrimidine ring is important for the success of heterocylization reaction.
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Chebanov, Valentin A., Vyacheslav E. Saraev, Ekaterina A. Gura, Sergey M. Desenko та Vladimir I. Musatov. "Some Aspects of Reaction of 6-Aminouracil and 6-Amino-2-Thiouracil with α,β-Unsaturated Ketones". Collection of Czechoslovak Chemical Communications 70, № 3 (2005): 350–60. http://dx.doi.org/10.1135/cccc20050350.

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A number of 5,7-diaryl-5,8-dihydropyrido[2,3-d]pyrimidines and 5,7-diarylpyrido[2,3-d]- pyrimidines were obtained by the reaction of 6-aminouracil derivatives with α,β-unsaturated ketones. Basic catalysts decrease yields of the dihydro derivatives whereas acids increase it. In the reactions of ketones containing the dimethylamino group, elimination of the aryl substituent from position 5 of the pyridopyrimidine system was observed. Some aspects of oxidation of 5,8-dihydropyrido[2,3-d]pyrimidines and synthesis of pyrido[2,3-d]pyrimidines were also investigated.
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Agarkov, A. S., A. K. Shiryaev, S. E. Solovieva, and I. S. Antipin. "Synthesis, chemocal properties and application of 2-substituted derivatives of thiazolo[3,2-<i>a</i>]pyrimidine." Журнал органической химии 59, no. 3 (2023): 285–315. http://dx.doi.org/10.31857/s0514749223030011.

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The review describes in detail the methods of obtaining thiazolo[3,2- a ]pyrimidines, synthesis and chemical properties of 2-substituted derivatives of thiazolo[3,2- a ]pyrimidines, analysis of crystal structures of 2-arylmethylidene derivatives of thiazolo[3,2- a ]pyrimidines and demonstrates their high antitumor, antibacterial and anti-inflammatory activity.
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Campos, Joana F., Thierry Besson, and Sabine Berteina-Raboin. "Review on the Synthesis and Therapeutic Potential of Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives." Pharmaceuticals 15, no. 3 (2022): 352. http://dx.doi.org/10.3390/ph15030352.

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The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics. We consider all the synthetic protocols to prepare these pyridopyrimidine derivatives. The review is organized into four sections, successively pyrido[2,3-d]pyrimidines, pyrido[3,4-d]pyrimidines, pyrido[4,3-d]pyrimidines and pyrido[3,2-d]pyrimidines. For each compound we present the biological activity and the synthetic route reported. To produce this manuscript, the bibliographic research was done using Reax
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Ofitserova, Ekaterina S., Lilia N. Alekseeva, Artem A. Shklyarenko, and Igor P. Yakovlev. "Biological activity of new 6-[(1-naphthylmethyl)thio)]-4-chloropyrazolo[3,4-d]pyrimidines." Aspirantskiy Vestnik Povolzhiya 20, no. 1-2 (2020): 146–51. http://dx.doi.org/10.17816/2072-2354.2020.20.1.146-151.

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Topicality. This article presents the results of the study of the biological activity of newly synthesized 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines. The acute toxicity of 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines was determined experimentally on non-linear white male mice with a total weight of 1620 g. A generation model was used to experimentally evaluate the analgesic activity acetic writhing in male mice. It was experimentally confirmed that the new synthesized 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines were non-toxic and had prono
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Liu, Xianxian, and Rebecca E. Parales. "Chemotaxis of Escherichia coli to Pyrimidines: a New Role for the Signal Transducer Tap." Journal of Bacteriology 190, no. 3 (2007): 972–79. http://dx.doi.org/10.1128/jb.01590-07.

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ABSTRACT Escherichia coli exhibits chemotactic responses to sugars, amino acids, and dipeptides, and the responses are mediated by methyl-accepting chemotaxis proteins (MCPs). Using capillary assays, we demonstrated that Escherichia coli RP437 is attracted to the pyrimidines thymine and uracil and the response was constitutively expressed under all tested growth conditions. All MCP mutants lacking the MCP Tap protein showed no response to pyrimidines, suggesting that Tap, which is known to mediate dipeptide chemotaxis, is required for pyrimidine chemotaxis. In order to confirm the role of Tap
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Dissertations / Theses on the topic "Pyrimidmes"

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Griffin, Roger J. "Novel biological roles for pyrimidines." Thesis, Aston University, 1986. http://publications.aston.ac.uk/12540/.

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The development of classical and lipophilic inhibitors of dihydrofolate reductase (DHFR) as antitumour agents is reviewed and the advantages and problems associated with each class are discussed. The antitumour activity, pharmacokinetics and metabolism of m-azido-pyrimethamine (MZP), a novel lipophilic inhibitor, are considered and compared with metoprine, the prototype lipophilic antifolate. Evidence for a folate-independent target for lipophilic DHFR inhibitors is presented. Synthetic studies centred on three principal objectives. Firstly a series of structural analogues of MZP were prepared
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Lee, Jeong-Hwan. "Synthesis of pyrrolo[2,3-d]pyrimidines and pyrazino[2,3-d]pyrimidines and their biological activities." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14350.

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Langlet, Abraham. "Nitration of oxo-pyrimidines and oxo-imidazoles /." Stockholm, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-601.

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Parks, Emma Louise. "Polyfunctionalised pyrimidines and pyrazines from perhalogenated precursors." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2551/.

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Chapter 1 introduces the modem pharmaceutical industry in terms of the drug discovery process leading into a discussion of the relevance of heterocyclic compounds with particular focus on the synthesis of multifunctional pyrimidines and pyrazines. An introduction into organofluorine chemistry is included followed by a review of the literature on 5-chloro-trifluoropyrimidine, tetrafluoropyrimidine and tetrafluoropyrazine. Chapter 2 describes a study of the reactivity of 5-chlorotrifluoropyrimidine with mono- and difunctional-nucleophiles. This research demonstrates the former are not selective
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Swetnam, S. P. "N.M.R. studies of the protonation of pyrimidines." Thesis, Keele University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372826.

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Prieur, Vanessa. "Pyrrolo[2,3-d]pyrimidines : conception, synthèse, fonctionnalisation." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2072/document.

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Les pyrrolo[2,3-d]pyrimidines, également connues sous le nom de 7-déazapurines, sont une classe importante d’hétérocycliques aromatiques, de par leurs potentiels biologiques (antitumoral, antiinflammatoire, antibactérien, etc.). C’est pourquoi ce squelette a été une source d’intérêt pour les chimistes organiciens. Outre leurs atouts biologiques, ces molécules présentent également de remarquables propriétés physico-chimiques (fluorescence UV), ce qui permet de nouvelles applications en électronique. Bien que ces dernières années, un bon nombre de recherche ont été mises en oeuvre en vue de synt
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PERIGNON, JEAN-LOUIS. "Metabolisme des pyrimidines dans les cellules lymphoides humaines." Paris 6, 1987. http://www.theses.fr/1987PA066799.

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Afin d'estimer le role du metabolisme intermediaire des pyrimidines dans la reponse immunitaire, la fonction immunitaire de deux malades ayant un deficit enzymatique hereditaire portant sur la voie de synthese de novo des pyrimidines (oroticurie) est etudie. Le metabolisme intermediaire des nucleosides pyrimidiques dans des lymphocytes et lymphoblastes humains fait l'objet d'une deuxieme etude
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Barnes, Samuel. "Synthesis of 2, 4-distributed pyrimidines of possible biological interest." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-05012008-164917/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Lucjan Strekowski, committee chair; A.L. Baumstark, Jerry Smith, committee members. Electronic text (83 p. : ill.) : digital, PDF file. Description based on contents viewed August 8, 2008. Includes bibliographical references (p. 44-46).
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Ratelle, Guillaume. "Incorporation spécifique d'une pyrimidine oxydée dans l'ADN cellulaire." Sherbrooke : Université de Sherbrooke, 2001.

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Tkacz, Victoria. "Synthesis of thieno[2,3]-pyrimidines as candidate antileishmanial agents." Connect to resource, 2006. http://hdl.handle.net/1811/6636.

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Thesis (Honors)--Ohio State University, 2006.<br>Title from first page of PDF file. Document formatted into pages: contains 14 p.; also includes graphics. Includes bibliographical references (p. 8). Available online via Ohio State University's Knowledge Bank.
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Books on the topic "Pyrimidmes"

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Brown, D. J. Pyrimidines. Wiley, 1993.

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J, Brown D., ed. Fused pyrimidines. Wiley, 1988.

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Delia, Thomas J. Miscellaneous fused pyrimidines. Wiley, 1992.

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Griffin, Roger John. Novel biological roles for pyrimidines. Aston University. Department of Pharmaceutical Sciences, 1986.

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Lister, John Henry. The purines. Wiley, 1996.

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Pfleiderer, Mathias. Synthese und Eigenschaften 6-substituierter Pyrido[2,3-d]pyrimidine. Hartung-Gorre, 1986.

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Brown, D. J. Pteridines. Wiley, 1988.

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Omar, Abdirahman Hagi Hassan. Reactions of trihalomethyl derivatives of pyridines and pyrimidines with nucleophiles. University of Salford, 1986.

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Kats, Eynav. חקר המנגנון ואופטימיזציה של תהליכי הסינתזה של פירימידינים ות. אוניברסיטת בן גוריון בנגב, 2006.

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International Symposium on Human Purine and Pyrimidine Metabolism (6th 1988 Hakone-machi, Japan). Purine and pyrimidine metabolism in man VI. Plenum Press, 1989.

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Book chapters on the topic "Pyrimidmes"

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Brown, E. G. "Pyrimidines." In Ring Nitrogen and Key Biomolecules. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4906-8_5.

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Mehlhorn, Heinz. "Pyrimidines." In Encyclopedia of Parasitology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_2622-2.

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Mehlhorn, Heinz. "Pyrimidines." In Encyclopedia of Parasitology. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_2622.

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Dudaş, Nicoleta A., and Mihai V. Putz. "Pyrimidines." In New Frontiers in Nanochemistry. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429022937-41.

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Li, Jie Jack, and Minmin Yang. "Pyrimidines." In Drug Discovery with Privileged Building Blocks. CRC Press, 2021. http://dx.doi.org/10.1201/9781003190806-24.

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Saladino, Raffaele. "Formamido Pyrimidines." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-65093-6_5448.

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Saladino, Raffaele. "Formamido Pyrimidines." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-642-27833-4_5448-1.

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Smith, C. A., and E. J. Wood. "Purines and pyrimidines." In Biosynthesis. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2356-3_7.

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Unger, Leon. "Purines and Pyrimidines." In Oklahoma Notes. Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4612-4200-0_11.

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Jeffrey, George A., and Wolfram Saenger. "Purines and Pyrimidines." In Hydrogen Bonding in Biological Structures. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-85135-3_15.

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Conference papers on the topic "Pyrimidmes"

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Lukovits, I., T. Kosztolányi, E. Kálmán, and G. Pálinkás. "Corrosion Inhibitors: Correlation between Chemical Structure and Efficiency." In CORROSION 1999. NACE International, 1999. https://doi.org/10.5006/c1999-99242.

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Abstract Corrosion inhibition efficiencies of heterocyclic, aromatic or partially saturated aromatic compounds (pyrimidines, benzothiazole derivatives, amino-acids containing an aromatic part, pyridines and quinolines) were correlated with quantum chemical indices of the respective molecules. Inhibition efficiencies measured in acidic solutions containing 0.001 and 0.01 mol/L of the inhibitor, respectively, were collected. The quantum chemical calculations were done by using the simple Hückel method. Comparison of inhibition efficiencies and the differences between energies of the highest occu
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Basha, N. Hussain, T. Rekha, G. Sravya, N. Bakthavatchala Reddy, Grigory V. Zyryanov, and V. Padmavathi. "Azolyl pyrimidines-synthesis and antimicrobial activity." In ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0070395.

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CIOBANU, Natalia, and Fliur МACAEV. "Selection of the optimum method for the synthesis of dihydropyrimidin-2-ones(thiones) using various biocatalysts." In International Congress "Research – Innovation – Innovative Entrepreneurship". Ion Creangă Pedagogical State University, 2024. https://doi.org/10.46727/c.17-18-05-2024.p264-267.

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The relevance of pyrimidines is well known due to their wide range of biological activities, pharmacophoric fragments of their constituent structures. Their use in the field of drug research has stimulated the expansion of the range of synthetic production methods, especially in conditions of respect for the protection of ecology and the environment in general.
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Slivka, Mar V., M. M. Fizer, D. Zh Bereksazi, et al. "Preparation of Bioactive Fused Pyrimidines via Environmental Technologies." In 2019 International Council on Technologies of Environmental Protection (ICTEP). IEEE, 2019. http://dx.doi.org/10.1109/ictep48662.2019.8968984.

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Mukhin, E., V. Fedotov, E. Ulomsky, and V. Rusinov. "NON-NATURAL NUCLEOSIDES BASED ON AZOLO[1,5-A]PYRIMIDINES." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m771.aks-2019/279-280.

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Koos, M., B. Steiner, and J. Gajdos. "Synthesis of Some Sulfur Bridged Pyrimidines, Pyrazoles and Imidazoles." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02002.

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Shutalev, Anatoly, and Anastasia Fesenko. "A Novel Ring Expansion of Pyrimidines to 1,2,4-Triazepines." In The 20th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a018.

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Rathod, Pravinsinh I., A. T. Oza, P. Predeep, Mrinal Thakur, and M. K. Ravi Varma. "Infrared Spectroscopy of Charge Transfer Complexes of Purines and Pyrimidines." In OPTICS: PHENOMENA, MATERIALS, DEVICES, AND CHARACTERIZATION: OPTICS 2011: International Conference on Light. AIP, 2011. http://dx.doi.org/10.1063/1.3643633.

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Benzenine, Djamila, Zahira Kibou, Amina Berrichi, Redouane Bachir, and Noureddine Choukchou-Braham. "New Synthesis of Imidazo[1,2-a]pyrimidines Catalyzed Using Gold Nanoparticles." In ECSOC-25. MDPI, 2021. http://dx.doi.org/10.3390/ecsoc-25-11690.

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Syahri, Jufrizal, Rahmadini Syafri, Hasmalina Nasution, Della Pratiwi, Emmy Yuanita, and Beta Achromi Nurohmah. "Design of 2-Phenylamino Benzothiopyrano [4,3-D] Pyrimidines Compound as an Anticancer." In Proceedings of the International Conference of CELSciTech 2019 - Science and Technology track (ICCELST-ST 2019). Atlantis Press, 2019. http://dx.doi.org/10.2991/iccelst-st-19.2019.14.

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Reports on the topic "Pyrimidmes"

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Wallace, Susan S. Structure/Function Analysis of DNA-glycosylases That Repair Oxidized Purines and Pyrimidines and the Influence of Surrounding DNA Sequence on Their Interactions. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/900301.

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