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Dissertations / Theses on the topic 'Pyrimidmes'

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Published: 5 June 2025
Last updated: 1 August 2025

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1

Griffin, Roger J. "Novel biological roles for pyrimidines." Thesis, Aston University, 1986. http://publications.aston.ac.uk/12540/.

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The development of classical and lipophilic inhibitors of dihydrofolate reductase (DHFR) as antitumour agents is reviewed and the advantages and problems associated with each class are discussed. The antitumour activity, pharmacokinetics and metabolism of m-azido-pyrimethamine (MZP), a novel lipophilic inhibitor, are considered and compared with metoprine, the prototype lipophilic antifolate. Evidence for a folate-independent target for lipophilic DHFR inhibitors is presented. Synthetic studies centred on three principal objectives. Firstly a series of structural analogues of MZP were prepared
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2

Lee, Jeong-Hwan. "Synthesis of pyrrolo[2,3-d]pyrimidines and pyrazino[2,3-d]pyrimidines and their biological activities." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14350.

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3

Langlet, Abraham. "Nitration of oxo-pyrimidines and oxo-imidazoles /." Stockholm, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-601.

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4

Parks, Emma Louise. "Polyfunctionalised pyrimidines and pyrazines from perhalogenated precursors." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2551/.

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Chapter 1 introduces the modem pharmaceutical industry in terms of the drug discovery process leading into a discussion of the relevance of heterocyclic compounds with particular focus on the synthesis of multifunctional pyrimidines and pyrazines. An introduction into organofluorine chemistry is included followed by a review of the literature on 5-chloro-trifluoropyrimidine, tetrafluoropyrimidine and tetrafluoropyrazine. Chapter 2 describes a study of the reactivity of 5-chlorotrifluoropyrimidine with mono- and difunctional-nucleophiles. This research demonstrates the former are not selective
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5

Swetnam, S. P. "N.M.R. studies of the protonation of pyrimidines." Thesis, Keele University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372826.

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6

Prieur, Vanessa. "Pyrrolo[2,3-d]pyrimidines : conception, synthèse, fonctionnalisation." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2072/document.

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Les pyrrolo[2,3-d]pyrimidines, également connues sous le nom de 7-déazapurines, sont une classe importante d’hétérocycliques aromatiques, de par leurs potentiels biologiques (antitumoral, antiinflammatoire, antibactérien, etc.). C’est pourquoi ce squelette a été une source d’intérêt pour les chimistes organiciens. Outre leurs atouts biologiques, ces molécules présentent également de remarquables propriétés physico-chimiques (fluorescence UV), ce qui permet de nouvelles applications en électronique. Bien que ces dernières années, un bon nombre de recherche ont été mises en oeuvre en vue de synt
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7

PERIGNON, JEAN-LOUIS. "Metabolisme des pyrimidines dans les cellules lymphoides humaines." Paris 6, 1987. http://www.theses.fr/1987PA066799.

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Afin d'estimer le role du metabolisme intermediaire des pyrimidines dans la reponse immunitaire, la fonction immunitaire de deux malades ayant un deficit enzymatique hereditaire portant sur la voie de synthese de novo des pyrimidines (oroticurie) est etudie. Le metabolisme intermediaire des nucleosides pyrimidiques dans des lymphocytes et lymphoblastes humains fait l'objet d'une deuxieme etude
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8

Barnes, Samuel. "Synthesis of 2, 4-distributed pyrimidines of possible biological interest." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-05012008-164917/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Lucjan Strekowski, committee chair; A.L. Baumstark, Jerry Smith, committee members. Electronic text (83 p. : ill.) : digital, PDF file. Description based on contents viewed August 8, 2008. Includes bibliographical references (p. 44-46).
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9

Ratelle, Guillaume. "Incorporation spécifique d'une pyrimidine oxydée dans l'ADN cellulaire." Sherbrooke : Université de Sherbrooke, 2001.

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10

Tkacz, Victoria. "Synthesis of thieno[2,3]-pyrimidines as candidate antileishmanial agents." Connect to resource, 2006. http://hdl.handle.net/1811/6636.

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Thesis (Honors)--Ohio State University, 2006.<br>Title from first page of PDF file. Document formatted into pages: contains 14 p.; also includes graphics. Includes bibliographical references (p. 8). Available online via Ohio State University's Knowledge Bank.
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11

Barnes, Samuel. "Synthesis of 2,4-Disubstituted Pyrimidines of Possible Biological Interest." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/chemistry_theses/10.

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The synthesis of 2,4-disubstituted pyrimidine derivatives is described. The synthetic route involved the addition reaction of lithiated intermediates, mostly heterocycles, to position 4 of 2-chloropyrimidine to give a dihydropyrimidine intermediate which was oxidized back to a pyrimidine. This was followed by nucleophilic aromatic substitution with various amines of the chlorine in the position 2. A number of compounds were prepared which showed binding towards various serotonin receptors in preliminary biological evaluation.
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12

Pouliquen, Laure. "Deazaguanines (pyrrolo(2,3-d)pyrimidines) as potential antiparastic drugs." Thesis, University of Strathclyde, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502340.

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Malaria, Leishmania and Tiypanasomia are parasitic diseases which are very severe in number of countries, essentially tropical. Due to the massive proliferation of these diseases and the increase of resistance against drugs usually used, current treatments are no more efficient and expose the patient to very severe side effects, which can cause death in the most severe cases.
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13

Wessner, Rachael Ann. "Theoretical Estimation of pKa’s of Pyrimidines and Related Heterocycles." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1469798346.

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14

Nicolle, Edwige. "Nouvelles thiazolidino [3,2-a] pyrimidines : synthèse, étude structurale et pharmacologique." Université Joseph Fourier (Grenoble), 1990. http://www.theses.fr/1990GRE18007.

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15

Do, Khoa Quang. "Design, Synthesis and Binding Studies of Trisubstitutedpyrazolo[3,4-d]pyrimidines." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367533.

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Pyrazolo[3,4-d]pyrimidines were known as adenosine antagonists at the rat A1 and A2A adenosine receptors based on our previous studies. In this study, 245 pyrazolo[3,4-d]pyrimidines derivatives with various benzyl substitutents at N-1 and various hydrophobic side chains at C-4 and C-6 were synthesized and screened at the human A1, A2A and A3 adenosine receptors. 14 out of 245 compounds were resynthesized and purified to determine the Ki values of these compounds at the human A1 adenosine receptor. Chapter 1 of the thesis is a literature review of adenosine research. It describes the physiology
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16

Entezampour, Mohammad. "Quantitation of Endogenous Nucleotide Pools in Pseudomonas aeruginosa." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc500491/.

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Nucleotide pools were extracted and quantified from Pyr^+ and Pyr^- strains of P. aerucjinosa. Strains were grown in succinate minimal medium with and without pyrimidines, and nucleotides were extracted using trichloracetic acid (TCA; 6% w/v). The pyrimidine requirement was satisfied by uracil, uridine, cytosine or cytidine. Pyr^- mutants were starved for pyrimidines for two hours before nucleotide levels were measured. This starvation depleted the nucleotide pools which were restored to wild type levels by the addition of pyrimidines to the medium. When the pyrimidine analogue, 6-azauracil, k
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17

Simkovsky, Nadja Melitta. "Synthesis of some potential IKK inhibitors based around a pyrimidine scaffold." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367619.

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18

Brom, Jacques. "Squelettes pyrimidohétérocycliques dérivés d'amino- et d'hydrazino- uraciles." Mulhouse, 1991. http://www.theses.fr/1991MULH0205.

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Les 6-amino-, 6-hydrazino- et 6-(azavinyl) pyrimidinediones riches en électrons réagissent par leur carbone 5 avec différents électrophiles (l’O-tosylisonitrosomalodinitrile (OTMD), le tétracyanoéthylène (TCNE), l'acétylènedicarboxylate de diméthyle (DMAD), et le diméthylacétal du diméthylformamide (DMFDMA) pour conduire après cyclisation à toute une série d'hétérocycles polycycliques. La 6-amino-1,3-diméthylpyrimidine-2,4(1H, 3H)-dione fournit ainsi, avec l'OTMD, une lumazine précurseur de pyrimido [5,4-g] ptéridines, et avec le TCNE, une pyrido [2,3-d] pyrimidine. Une isomérisation du squele
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19

Simon, Gaëlle. "Analogues et dérivés des méridianines : Synthèse et Étude structure-activité biologique." Brest, 2004. http://www.theses.fr/2004BRES2011.

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Le milieu marin est une source de molécules bioactives originales. Les méridianines, indoles substitués en position 3 par un reste pyrimidine, font partie de ces molécules découvertes récemment qui présentent une activité inhibitrice des kinases cycline-dépendantes. Afin de compléter les premiers tests biologiques sur ces indolopyrimidines, nous rapportons dans un premier temps la synthèse d'analogues NH des méridianines par deux voies : un couplage de Suzuki entre des acides indolylboroniques et une 2-amino-4-chloropyrimidine et, la formation d'un cycle 2-aminopyrimidine par condensation de l
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20

Hou, Geneviève. "Synthèse de pyrido et de thiénopyrimidin-4(3H)-ones et de leurs produits de réduction : intérêt potentiel de ces composés dans le traitement de la thrombose." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2E001.

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21

Gayon, Eric. "Stratégies pour l'accès rapide à des hétérocycles azotés à partir d'alcools propargyliques." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2012. http://www.theses.fr/2012ENCM0017/document.

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La partie principale de ce manuscrit traite du développement de nouvelles méthodologies utilisant la substitution propargylique catalysée par des sels de fer(III), pour la formation de divers hétérocycles azotés (∆4-isoxazolines, isoxazoles, cis-acylaziridines et pyrimidines). En premier lieu, de nouvelles synthèses monotopes de ∆4-isoxazolines et d'isoxazoles diversement substitués impliquant des réactions de cyclisation catalysées par diverses espèces carbophiles ([Au], [Pd], [I+]) ont été développées. La fragilité de la liaison N-O des ∆4-isoxazolines a pu être ensuite exploitée pour condui
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22

Scammells, Peter J., and n/a. "Pyrazolo(3,4-d)Pyrimidines and adenosine receptors: a structure/activity study." Griffith University. Division of Science and Technology, 1990. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050826.141630.

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Pyrazolopyrimidines are a general class of compounds which exhibit Aj adenosine receptor affmity. A number of pyrazolo(3,4-d)pyrimidine analogues of isoguanosine and i-methylisoguanosine has been synthesised. All compounds were tested forAi adenosine receptor affinity using a (311) R-PIA competitive binding assay. The N-i and N-5 positions were substituted with a number of different ailcyl and aryi groups. 3-Chiorophenyl substitution of the N-i position and butyl substitution of the N-5 position greatly enhanced the overall adenosine receptor affinity. Substitution by a methyl group at the N-7
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23

Doise, Muriel. "Synthèse d'oxazolo et d'imidazo(m, n-x)pyridines, pyrimidines et pyrazines." Lille 1, 1991. http://www.theses.fr/1991LIL10129.

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Ce travail décrit la synthèse et l'étude structurale de nouveaux composés hétérocycliques condensés dérivés d'orthohydroxyaminoazines. La première partie est consacrée à la synthèse de deux nouveaux hétérocycles fondamentaux isostères de la purine: l'oxazolo(4,5-b)pyridine et de l'oxazolo(4,5-d) pyrimidine ainsi que celle de leurs dérivés substitués en -2; cette seconde série était jusqu'alors inconnue. La seconde partie décrit la synthèse de nouveaux phénols susceptibles de présenter des propriétés complexantes en série imidazo(1,2-a)pyridine et pyrazine par condensation de glyoxals avec la b
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24

Léger, Dominique. "L'aspartate transcarbamylase, enzyme clef de la regulation du metabolisme des pyrimidines." Paris 6, 1987. http://www.theses.fr/1987PA066181.

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25

Scammells, Peter. "Pyrazolo(3,4-d)Pyrimidines and adenosine receptors: a structure/activity study." Thesis, Griffith University, 1990. http://hdl.handle.net/10072/365214.

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Pyrazolopyrimidines are a general class of compounds which exhibit Aj adenosine receptor affmity. A number of pyrazolo(3,4-d)pyrimidine analogues of isoguanosine and i-methylisoguanosine has been synthesised. All compounds were tested forAi adenosine receptor affinity using a (311) R-PIA competitive binding assay. The N-i and N-5 positions were substituted with a number of different ailcyl and aryi groups. 3-Chiorophenyl substitution of the N-i position and butyl substitution of the N-5 position greatly enhanced the overall adenosine receptor affinity. Substitution by a methyl group at the N-7
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26

Majumdar, Papiya. "Nitrosative guanosine deamination pyrimidine ring opening implications of effects in homogeneous solution as well as ansiotropic environments /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5967.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed Oct. 16, 2007). Vita. Includes bibliographical references.
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27

Farajallah, Azizeh M. "Focused chemical libraries targeting pyrimidine metabolism in Plasmodium falciparum /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8652.

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28

Mainguet, Samuel. "Caractérisation moléculaire et fonctionnelle du recyclage de l'uracile par l'uracile-phosphoribosyltransférase d'Arabidopsis thaliana." Paris 11, 2009. http://www.theses.fr/2009PA112278.

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L’UMP est le précurseur de toutes les pyrimidines, lesquelles sont requises pour la synthèse des acides nucléiques, des glycérolipides, et des glycoprotéines. Il peut être formé par la voie de novo, coûteuse en énergie, ou par le recyclage de nucléobases ou nucléosides. Jusqu'alors, les Uracile PhosphoRibosylTransferases, qui recyclent l’uracile en UMP, étaient décrites comme non-essentielles, mais aucun mutant pour cette voie n’était étudié chez les plantes. L’étude de la famille de gènes annotés comme UPRT chez Arabidopsis a permis d’identifier un gène unique (UPP) codant pour une protéine p
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29

Masson, Anne. "Etude genetique, physiologique et biochimique du metabolisme des pyrimidines chez lactobacillus plantarum." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13189.

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Le metabolisme des pyrimidines chez lactobacillus plantarum, bacterie d'interet agroalimentaire, a ete aborde par des methodes physiologiques et genetiques. Des techniques de mutagenese et d'enrichissement en mutants auxotrophes ont ete mises au point et ont permis d'obtenir de 1 a 9% de mutants parmi la population de bacteries. Des mutants auxotrophes pour les purines, l'histidine, la serine, l'uracile, la thymine, la cytidine. . . Ont ete obtenus. Les mutants auxotrophes pour l'uracile ont ete etudies en dosant les 5 enzymes de biosynthese des pyrimidines. Des mutants deficients dans chacune
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30

Blake, Ava L. "Synthesis of Substituted Pyrimidines and Pyridines as Ligands to the 5-HT7 Receptor." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/29.

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Of the seven existing classes of serotonin receptors, the 5-HT7 receptors (5-HT7Rs) are the most recently discovered. Abundance of 5-HT7 in the central nervous system is suggestive of the receptor’s role in several physiological and pathophysiological functions. Existing research has afforded a number of compounds exhibiting specific affinity to the receptor. These selective ligands can provide structural information about the receptor and can serve as the foundation for pharmacological profiling . This thesis describes the synthesis of substituted pyrimidines and pyridines for affinity to the
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31

McLachlan, Janice. "Synthesis of 2-amino-4-(thiazol-5-yl) pyrimidines as potential kinase inhibitors." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12637.

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32

Poulsen, Sally-Ann, and n/a. "Pyrazolo(3,4-d)pyrimidines: Synthesis and Structure-Activity Relationships for Binding to Adenosine Receptors." Griffith University. School of Science, 1996. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050901.161632.

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Chapter 1 of thesis is a literature review of adenosine research. The central importance of the contributions of both classical pharmacology and, more recently, molecular biology to adenosine research is demonstrated. These disciplines have enabled the classification and characterisation of adenosine receptors and as well an understanding of the physiological significance of endogenous adenosine. The significant benefits of developing therapeutics for regulation of the diverse physiological functions of adenosine, by regulation of adenosine receptors, is outlined. For this therapeutic potentia
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33

McIntyre, Neil A. "Synthesis of ring-constrained thiazolylpyrimidines : inhibitors of cyclin-dependent kinases /." St Andrews, 2007. http://hdl.handle.net/10023/353.

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34

Zhang, Min. "Study on selective carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds formation starting from alkynes." Rennes 1, 2009. http://www.theses.fr/2009REN1S036.

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The thesis is composed of two parts. Part I presents catalytic C-C, C-N, C-O bond formation: a series of dienylethers, 2,5-disubstituted furans, allylketones, γ-functionalized ketones, multisubstituted quinolines were made starting from terminal alkynes with the initial help of a ruthenium catalyst. Part II presents C-C, C-N, C-O bond formation reactions: a variety of tetrahydropyrimidines, and 1,3-oxazines were synthesized starting from electron-deficient alkynes via multiple component reactions<br>La thèse est composée de deux parties. La partie I présente la formation catalytique de liaison
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35

Moldovan, Salomia-Oana. "Ingénierie des systèmes conjugués A-π-D diaziniques et évaluation de leurs propriétés opto-électroniques. Mélamines spirodendritiques à partir des amino-1,3-dioxanes sérinoliques enantiopures. Design, synthèse et analyse structurale". Rouen, 2012. http://www.theses.fr/2012ROUES023.

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Our work described in this Ph. D Thesis comprises two parts entitled as Chapters. The research reported in Chapter1 concerns the synthesis and photophysical properties of new fluorophore A-π-D using diazine moiety as π-acceptor. The research reported in Chapter 2 concerns the design, synthesis and structural analysis of some new spiro-dendritic chiral melamines with peripheral units of type serinol / serinol-aminoacetal. The first Chapter presents the synthesis of a new A-π-D fluorophore using Sonogashira cross coupling reaction and copper-catalyzed Huisgen 1,3-dipolar cycloaddition. The targe
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36

Poulsen, Sally-Ann. "Pyrazolo(3,4-d)pyrimidines: Synthesis and Structure-Activity Relationships for Binding to Adenosine Receptors." Thesis, Griffith University, 1996. http://hdl.handle.net/10072/365893.

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Chapter 1 of thesis is a literature review of adenosine research. The central importance of the contributions of both classical pharmacology and, more recently, molecular biology to adenosine research is demonstrated. These disciplines have enabled the classification and characterisation of adenosine receptors and as well an understanding of the physiological significance of endogenous adenosine. The significant benefits of developing therapeutics for regulation of the diverse physiological functions of adenosine, by regulation of adenosine receptors, is outlined. For this therapeutic potentia
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37

White, David Charles. "Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/46506.

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A series of 2-alkyl-3-arylpyrido[2,3-d]pyrimidones were synthesized for testing as potential antiepileptic drugs. The goal was to achieve better neurological activity and/or lower toxicity than displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. From the pharmacological testing data of these target compounds, we have found that the additional nitrogen at the C-8 position of the quinazolinone framework increased the anticonvulsant activity. However, the neurological toxicity increased as well. The anticonvulsant and neurotoxic activi
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38

Goulet, Daniel. "Approche physico-chimique et cellulaire de la photosensibilisation des pyrimidines par l'écran solaire PABA." Thèse, Université de Sherbrooke, 1986. http://hdl.handle.net/11143/11729.

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L'acide para-aminobenzoïque (PABA) est l'un des principaux filtres solaires que l'on retrouve dans les crèmes de bronzage commerciales. Toutefois, son rôle de protection antisolaire (UV-B) est basé uniquement sur ses propriétés d'absorption dans la zone d'érythème, c'est-à-dire une approche purement photophysique. Nous nous sommes posés la question suivante: Existe-il différents effets photochimiques au niveau de la cellule en présence de PABA? La littérature mentionne que la présence de PABA cause des dommages importants de l'ADN cellulaire, suite à une irradiation dans la zone spectrale supé
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39

Cheng, Dachen. "Generation of novel heterocyclic building blocks : Synthesis of substitued pyrido (1,2-a) pyrimidines (Bicyclopyridones)." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500393.

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40

Pradere, Ugo. "Synthèse métallo-catalysée d'analogues de nucléosides et d'oxazolo[4,5-d]pyrimidines à visée thérapeutique." Phd thesis, Université d'Orléans, 2009. http://tel.archives-ouvertes.fr/tel-00665129.

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Les nucléosides représentent avec plus de 40 composés approuvés la pierre angulaire des chimiothérapies antivirales. Leur émergence progressive depuis maintenant prés de 50 ans a conduit à des progrès considérables dans la lutte contre de nombreuses infections virales comme les herpès, les hépatites ou le SIDA. Néanmoins, l'apparition de résistances et la toxicité intrinsèque des molécules poussent la recherche à développer de nouveaux analogues nucléosidiques plus actifs et plus surs. Dans cette optique, les réactions organo-métallliques sont des outils efficaces pour la synthèse de nouveaux
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41

Hermansen, Russell A., Brian K. Mannakee, Wolfgang Knecht, David A. Liberles, and Ryan N. Gutenkunst. "Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610280.

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BACKGROUND: Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes. RESULTS: Gene families across yeast were constructed for each member of the pathway and the ratio of nonsynonymous to synonymous nucleotide substitution rates (d
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42

GAYE-SEYE, MAME DIABOU. "Etude spectroscopique de purines et pyrimidines : fluorescence, phosphorescence et spectrometrie d'absorption derivee : applications analytiques." Paris 7, 1989. http://www.theses.fr/1989PA077146.

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Etude de proprietes de l'etat excite singulet (moment dipolaire, phosphorescence et spectres uv derives) de purines et de pyrimidine d'interet biomedical, et de leur melange. Determination, par solvatochromisme, des moments dipolaires. Bon accord entre les valeurs theoriques (methode pariser parr pople) et experimentales. Analyse de purines, pyrimidines et de leur melange par phosphorescence a temperature ambiante, et par une methode spectrometrique uv derivee: identification et quantification
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43

LILJELUND, PATRICIA. "Recherche et etude de mutants intervenant dans la biosynthese des pyrimidines chez saccharomyces cerevisiae." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13011.

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Liljelund, Patricia Marie. "Recherche et étude de mutants intervenant dans la biosynthèse des pyrimidines chez Saccharomyces cerevisiae." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb375991982.

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45

Vieira, Andreia Sofia da Costa. "Rethinking Triazoles as Antifungals: Synthesis and Evaluation of New Triazole Derivatives." Master's thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2017. http://hdl.handle.net/10362/81407.

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"In the last decades, fungal infections have become a serious problem, mainly due to the excessive use of this reduced number of drugs, leading to an increase of acquired resistances1. Therefore, it is urgent to develop new and more effective antifungal medicines. The main objective of this master's thesis was the development of novel antifungal drugs, based on triazoles and pyrimidines, combining two groups with antifungal properties, known to be active in combinatorial therapies, in a single molecule. For the synthesis of these compounds, Huisgen's 1,3-dipolar cycloaddition methodologies, c
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46

Fossey, Christine. "Synthèse de nucléosides pyrimidiniques à visée antivirale (anti-sida) possédant un aglycone original : la thiéno (3,2-d) pyrimidine-2, 4-dione." Caen, 1992. http://www.theses.fr/1992CAEN4047.

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Neyret, Claire. "De l'analyse des caramels à la synthèse et à la valorisation du 5-hydroxyméthylfurfural." Lyon 1, 1990. http://www.theses.fr/1990LYO10140.

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La fabrication de caramels industriels par chauffage de differents sucres en presence ou non de catalyseurs provoque des vapeurs de cuisson actuellement rejetees dans les eaux de fabrication apres condensation. L'analyse qualitative et quantitative de ces condensats par couplage de la chromatographie en phase gazeuse et de la spectrometrie de masse a ete realisee. Les resultats montrent la presence en faible proportion (0,2 a 15%) de composes furaniques et d'aromes. En effet, le principal sous-produit obtenu lors de la caramelisation est le 5-hydroxymethylfurfural (hmf) dont le pourcentage var
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48

Hooten, Jody J. (Jody Jeran). "Identification and Characterization of the Pyrimidine Biosynthetic Operon in Streptomyces griseus." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc277975/.

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To further understand the ATCase/DHOase bifunctional complex formed in Streptomyces, the genes encoding these and other pyrimidine enzymes were identified and characterized. Polymerase chain reaction (PCR) was utilized in this effort. Primers were constructed by selecting conserved regions of pyrimidine genes from known gene and protein sequences of a wide variety of organisms. These sequences were then optimized to Streptomyces codon usage. PCR products were obtained from internal sites within pyrimidine genes and also from primer combinations of different genes. The size, orientation, and
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Baret, Nathalie. "Fonctionalisation de pyrimidinédiones : accès à des analogues de nucléosides." Aix-Marseille 3, 1996. http://www.theses.fr/1996AIX30125.

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Les nucleosides modifies presentent de nombreuses activites biologiques importantes notamment en chimiotherapie anticancereuse ou antivirale. Leurs methodes de synthese ont fait l'objet de nombreuses recherches. La cohalogenation par le n-bromosuccinimide (nbs) en presence d'alcools propargyliques diversement substitues, de la double liaison en c5-c6 de l'uracile, de la thymine ou des nucleosides derives a permis de preparer les 5-bromo 4-propynyloxyethers correspondants. En presence de triethylamine, ces composes sont transformes en methylene-tetrahydrofuranes, selon une reaction de carbocycl
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Ibrahim, Mohamed M. "Pyrimidine Metabolism in Rhizobium: Physiological Aspects of Pyrimidine Salvage." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc330907/.

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The objective of this research was to study the pyrimidine salvage pathways of Rhizobium. Three approaches were used to define the pyrimidine salvage pathways operative in two species of Rhizobium, R. meliloti and R. leguminosarum . The first approach was to ascertain the pyrimidine bases and nucleosides that could satisfy the pyrimidine requirement of pyrimidine auxotrophs. Uracil, cytosine, uridine or cytidine all satisfied the absolute pyrimidine requirement. The second approach was to select for mutants resistant to 5-fluoropyrimidine analogues which block known steps in the interconversio
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