Academic literature on the topic 'Quasi emulsion solvent diffusion method'

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Journal articles on the topic "Quasi emulsion solvent diffusion method"

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Tyagi, Gajendra, and Suresh Choudhary. "Preparation of flutrimazole micro sponge gel by quasi-emulsion solvent diffusion method." Asian Journal of Pharmaceutical Research and Development 12, no. 3 (2024): 43–49. http://dx.doi.org/10.22270/ajprd.v11i3.1393.

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Microsponge containing Flutrimazole drug with six different proportions of Eudragit RS 100 as polymer were obtained successfully using quasi-emulsion solvent diffusion method. Particle size and physical properties of the formulations were examined. Physical properties showed that microsponge formulations MS IV and MS VI exhibited better material efficiency and yield. Two microsponge formulations were prepared as gels in 0.35% w/w carbomer and examined for pH, viscosity, permeability, drug content, in vitro release, antibacterial activity, and in vivo antifungal activity on Rabbit skin. The vis
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Maghsoodi, Maryam, and Ali Nokhodchi. "Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer." Advanced Pharmaceutical Bulletin 6, no. 4 (2016): 607–16. http://dx.doi.org/10.15171/apb.2016.075.

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Thenge, R. R., M. P. Chandak, and V. S. Adhao. "Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs." Asian Journal of Pharmaceutical Research and Development 8, no. 3 (2020): 104–10. http://dx.doi.org/10.22270/ajprd.v8i3.727.

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A greater challenge in solid dosage formulation is the development of spherical agglomerates which increases the solubility and bioavailability of the drug. Spherical crystallization is “An agglomeration process that transforms crystals directly into compact spherical forms during the crystallization process.” Spherical crystallization is the novel agglomeration technique that can transform directly the fine crystals produced in the crystallization process into a spherical shape. Direct Compression of powders is simple and easy way of making tablets. In direct compression of Good Compressibili
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Maghsoodi, Maryam, and Ali Nokhodchi. "Agglomeration of celecoxib by quasi-emulsion solvent diffusion method without stabilizer: effect of good solvent." Pharmaceutical Development and Technology 23, no. 10 (2017): 1037–46. http://dx.doi.org/10.1080/10837450.2016.1270965.

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Gaurav, Magar Dr. A. V. Chandewar Dr. M. A. Channawar Satyam Pendor Ashwini Warankar. "Studies On Various Techniques Used for Masking the Bitterness of Drug and Formulation Development." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3223–38. https://doi.org/10.5281/zenodo.15464093.

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The aim of the study was to mask the bitterness of Valsartan by various taste masking techniques. Quasi- emulsion solvent diffusion method, Inclusion complexation and spray drying these methods were used. Eudragit RS 100 and Ethyl Cellulose were used in 1:1, 1:1.5 and 1:2 ratios to create taste masked microsponges using Quasi- emulsion solvent diffusion method. Kneading method was used to formulate Inclusion complexes. β- Cyclodextrin was used as complexing agent. Various ratios of drug and β- Cyclodextrin were tried for taste masking.  Spray drying method was attempted to make
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Sujathan, Ponni, and Umesh Kumar Sharma. "Development and Characterization of Metronidazole Loaded Microsponges for the Management of Diabetic Foot." International Journal of Research and Review 8, no. 10 (2021): 440–57. http://dx.doi.org/10.52403/ijrr.20211059.

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The objective of present work was formulation and evaluation of Metronidazole loaded microsponges for the management of diabetic foot ulcer via topical application and to reduce side effects. The microsponges were prepared by quasi-emulsion solvent diffusion method using different concentrations of Ethyl cellulose and Poly vinyl alcohol. The prepared microsponges were evaluated for particle size analysis, SEM, % production yield, % drug entrapment efficiency, in-vitro drug release studies, DSC and antimicrobial studies. FTIR studies shown that there was no interaction between drug and polymers
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Shinde, Jitendra, Rakesh Patel, and Shweta Shriwas. "Formulation and Evaluation of Topical Microsponge Based Gel of Clotrimazole." International Journal of Membrane Science and Technology 10, no. 2 (2023): 2538–48. http://dx.doi.org/10.15379/ijmst.v10i2.2905.

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The study's overarching goal is to develop a novel medication delivery method based on microsponge gel containing clotrimazole. Clotrimazole is poorly absorbed from the gastrointestinal tract (GIT), has a short half-life of only 2 h, & is metabolized into inert molecules by the liver. Therefore, clotrimazole's drug delivery method must be modified for topical application. Microsponge delivery is a novel approach to sustained drug release. Microsponges were made with a polymer solution of Eudragit RS 100 in dichloromethane (DCM) and ethanol (1:1) using a quasi-emulsion solvent diffusion tec
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A. Nief, Roaa, and Ahmed A. Hussein. "Preparation and Evaluation of Meloxicam Microsponges as Transdermal Delivery System." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 23, no. 2 (2017): 62–74. http://dx.doi.org/10.31351/vol23iss2pp62-74.

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The aim of present study was to develop gel formulation of microsponges of poorly soluble drug meloxicam (MLX) in order to enhance the release and dissolution of MLX which is the limitation for preparation in topical forms. Also skin delivery is an alternative administration for MLX that can minimize gastrointestinal (GI) side effects and improve patient compliance. The microsponges of MLX were prepared by quasi-emulsion solvent diffusion method. The effects of drug:polymer ratio, stirring time and Eudragit polymer type on the physical characteristics of microsponges were investigated and char
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Budarapu, Divya, U. Mohan Kumar, and P. Sravanthi. "Design, Formulation and In-Vitro Evaluation of Ketoconazole Microsponges by Quasi-Emulsion Solvent Diffusion Method." Journal of Drug Delivery and Therapeutics 15, no. 7 (2025): 19–24. https://doi.org/10.22270/jddt.v15i7.7244.

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Ketoconazole-loaded micro sponges were successfully formulated employing the quasi-emulsion solvent diffusion technique, aiming to optimize drug entrapment efficiency and enhance sustain release of the drug. Ethyl cellulose served as the release-retarding polymer, while polyvinyl alcohol (PVA) functioned as the emulsifying agent. Formulations were prepared in varying ratios of drug: PVA: ethyl cellulose to assess the impact of composition on micro sponge properties. The effect of variables including the drug: polymer ratio, emulsifier (PVA) concentration in organic solvent (dichloro methane) w
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V., Lakshmi Durga* G. Pavani Priya V. Sai Kishore M. V. Sai Krishna. "PREPARATION AND CHARACTERIZATION OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISSOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF IBUPROFEN." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1414–21. https://doi.org/10.5281/zenodo.807176.

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The objective of the present work was to study the effect of different polymers on the solubility and dissolution rate of ibuprofen a poorly water soluble NSAIDs, by spherically agglomeration using methanol, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of ibuprofen were prepared by using polyethylene glycol-4000, polyethylene glycol-6000 and PVP k-30 as water soluble carries proportions like 1:0.5,1:0.75,1:1. The agglomerates wer
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Book chapters on the topic "Quasi emulsion solvent diffusion method"

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Aishwarya, KVNR, and Praveen Sivadasu. "Preparation of Rilpivirine Nanosponges Using Different Methodologies." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00611.

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Rilpivirine is an analogue of a nucleoside that inhibits reverse transcriptase. Various polymers including ethyl cellulose (EC), -cyclodextrin (-CD), polyvinyl alcohol (PVA), polyvinyl pyrrolidone K-30 (PVP K-30), cross-linkers including dichloromethane (DCM), dimethyl carbonate (DMC), glutaraldehyde (GTLD), stabilisers including kondagogu gum (kgg), olibanum gum (OLG), and solvents like ethanol, methanol, dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), dist. water etc were used with different proportion with respective methods of preparation. Emulsion Ultrasonic-assisted synthesis, solve
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M N, Madhavi, Pankaj M. Pimpalshende, Satish B. Kosalge, Shubhangi M. Kaurase, and Rajashree V. Lode. "A NOVEL APPROACH TO DRUG DELIVERY SYSTEMS: MICROSPONGES." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 16. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkpn16p2ch2.

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To maximize therapeutic efficacy and cost-effectiveness, innovative drug delivery technology has developed intensely competitive and is growing quickly. Microsponges are one of these cutting-edge developing techniques for precise, controlled, and target-specific medication administration. Microsponges are microscopic polymeric particles with porous surfaces resembling sponges, and pore ranges in size from 5 to 300 microns. The microsponge system can be made into gel, ointment, creams, liquids, or powders with good efficiency. More recently, it has been made into tablets and capsules for oral d
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R., Amit, Pravin S., and Dinesh M. "Preparation of Carvedilol Spherical Crystals Having Solid Dispersion Structure by the Emulsion Solvent Diffusion Method and Evaluation of Its in vitro Characteristics." In Advances in Crystallization Processes. InTech, 2012. http://dx.doi.org/10.5772/45805.

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"Fig. 12 Scanning electron micrograph of D.L-PLA nanoparticles loaded with CGP 57813. (Ref. 51.) scanning force microscopy (also called atomic force microscopy), enable the visualiza-tion of nanoparticles at atmospheric pressure without gold coating [12,64]. Neverthe-less, the resolution obtained with these new tools is still lower than that with SEM. For size determination, transmission electron microscopy is not as widely used as PCS and SEM, but it is still a powerful method for determining the morphology of particles. With this technique, Fessi et al. [42] estimated the wall thickness of PLA nanocapsules. Krause et al. [18] described the highly porous structure of PLA nano-spheres prepared by the emulsion-evaporation procedure. VIII. IN VITRO RELEASE STUDIES In vitro release studies should in principle be useful for quality control as well as for the prediction of in vivo kinetics. Unfortunately, due to the very small size of the par-ticles, the release rate observed in vivo can differ greatly from the release obtained in a buffer solution. However, in vitro release studies remain very useful for quality control as well as for evaluation of the influence of process parameters on the release rate of active compounds. In vitro drug release from microdispersed systems has been exten-sively reviewed by Washington [65]. Depending on the type of polyester, drug release from nanoparticles can take place through several processes, of which the following appear to be the most important: (1) The drug may diffuse out of the carrier through the solid matrix; to allow complete release from the carriers, (the concentration of drug in the release medium should re-main infinitely low, which condition is known as sink condition); (2) The solvent may penetrate the nanoparticles and dissolve the drug, which then diffuses out into the re-lease medium. Depending on the physico-chemical characteristics of the particles, wa-ter can enter the particles through narrow pores or by hydration. Once the drug is dis-solved, the drug diffuses out of the particles. Here again, since diffusion is driving the." In Pharmaceutical Dosage Forms. CRC Press, 1998. http://dx.doi.org/10.1201/9781420000955-25.

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