Academic literature on the topic 'Quinolic acid'

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Journal articles on the topic "Quinolic acid"

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Pierozan, Paula, Carolina G. Fernandes, Márcio F. Dutra, et al. "Biochemical, histopathological and behavioral alterations caused by intrastriatal administration of quinolic acid to young rats." FEBS Journal 281, no. 8 (2014): 2061–73. http://dx.doi.org/10.1111/febs.12762.

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Massieu, Lourdes, Natividad Rocamora, JoséMaria Palacios, and Hendrikus W. G. M. Boddeke. "Administration of quinolic acid in the rat hippocampus induces expression of c-fos and NGFI-A." Molecular Brain Research 16, no. 1-2 (1992): 88–96. http://dx.doi.org/10.1016/0169-328x(92)90197-j.

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Schwarzenbacher, Robert, Lukasz Jaroszewski, Frank von Delft, et al. "Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 Å resolution." Proteins: Structure, Function, and Bioinformatics 55, no. 3 (2004): 768–71. http://dx.doi.org/10.1002/prot.20029.

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YOKOYAMA, Takushi, Hikaru ABE, Tsutomu KURISAKI, and Hisanobu WAKITA. "13C and 27Al NMR and Potentiometric Study on the Interaction between Aluminium lons and Quinolic Acid in Acidic Aqueous Solutions." Analytical Sciences 15, no. 10 (1999): 969–72. http://dx.doi.org/10.2116/analsci.15.969.

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Bremner, JB, та W. Jaturonrusmee. "Manganese(III) Acetate-Induced Formation of a Fused, Chloro-Substituted β-Lactam Derivative From a Chloroacetamide". Australian Journal of Chemistry 43, № 8 (1990): 1461. http://dx.doi.org/10.1071/ch9901461.

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Reaction of 1-chloroacetyl-5-methoxy-2,3-dihydro-1H-dibenzo[de,h]quinoline (1) with manganese(III) acetate in acetic acid at 50° gave the novel fused spiro derivative 11-chloro-4-methoxy-1,2-dihydro-6H-azeto[2,1-f]dibenzo[de,h]quinoline-6,12(11H)-dione (6) in 21% yield, together with 5-methoxy-7H-dibenzo[de,h]quinolin-7-one (3), 5-methoxy-2,3-dihydro-7H-dibenzo[de,h]quinolin-7-one (4), and 1- chloroacetyl-5-methoxy-2,3-dihydro-1H-dibenzo[de,h]-quinolin-7-yl ethanoate (5) in 1, 3 and 44% yields respectively. Compound (5) was shown to be a precursor of (3), (4) and (6).
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Zozulynets, D. М., A. G. Kaplaushenko, and A. S. Korzhova. "The synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes." Journal of Organic and Pharmaceutical Chemistry 19, no. 1(73) (2021): 48–52. http://dx.doi.org/10.24959/ophcj.21.188137.

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Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reactionwith aldehydes.Results and discussion. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized, and a number of 4-(ethyl, aryl)idenamino derivatives were obtained on its basis.Experimental part. Using a series of four successive reactions based on quinoline-2-carboxylic acid, 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized; its interaction with aldehydes allowed to obtain a number of 4-(ethyl, aryl)idenamino derivatives. The structure of all compounds s
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Son, Jung-Ho, Sem Raj Tamang, Jason C. Yarbrough, and James D. Hoefelmeyer. "Hydrolysis of 8-(pinacolboranyl)quinoline: where is the 8-quinolylboronic acid?" Zeitschrift für Naturforschung B 70, no. 11 (2015): 775–81. http://dx.doi.org/10.1515/znb-2015-0031.

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AbstractThe compound 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-quinoline was prepared and found to hydrolyze rapidly in air; however, the expected product (quinolin-8-yl)boronic acid was not observed. Instead, the (quinolinium-8-yl)trihydroxyborate zwitterion or an anhydride were observed depending on the conditions of hydrolysis. The two products are related to one another in the degree of hydration, and the two forms could be interconverted. Both hydrolysis products were structurally characterized. Additionally, a commercial sample of ‘8-quinolylboronic acid’ was actually found to be t
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Levendis, Demetrius C., Jeffrey Moffit, Benjamin Staskun, and Theodorus van Es. "Thionyl Chloride-induced Conversion of 1-Ethyl-1,4-dihydro-2-methyl-4-oxoquinoline-3-carboxylic Acids to Highly Functionalised Thieno[3,4-b]quinoline Derivatives." Journal of Chemical Research 23, no. 10 (1999): 614–15. http://dx.doi.org/10.1177/174751989902301014.

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Warming a title acid with SOCl2 gives the corresponding 3,3,9-trichlorothieno[3,4- b]quinolin-1 (3 H)-one whereas reaction at room temperature leads to the intermediate 3,3-dichloro-4-ethylthieno[3,4- b]quinoline-1(3 H),9(4 H)-dione product as established from the respective X-ray crystallographic determinations.
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Li, Yang, Ming-qin Chang, Feng Gao, and Wen-tao Gao. "Facile synthesis of fused quinolines via intramolecular Friedel–Crafts acylation." Journal of Chemical Research 2008, no. 11 (2008): 640–41. http://dx.doi.org/10.3184/030823408x375070.

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The intramolecular cyclisation of 6-[(phenoxy/phenylthio)methyl][1,3]dioxolo[4,5-g]quinoline-7-carboxylic acids to [1]benzoxepino[3,4-b][1,3]dioxolo[4,5-g]quinolin-12(6H)-onesand[1]benzothiepino[3,4-b][1,3]dioxolo[4,5-g]quinolin-12(6H)-ones in the presence of Eaton's reagent (P2O5-MeSO3H) is described. This cyclisation protocol requires milder conditions than those traditionally employed and is characterised by relatively low reaction temperatures and ease of product isolation.
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Ramasamy, A. K., V. Balasubramaniam, and K. Mohan. "Synthesis and Characterization of Substituted 4-Methoxy-1H-quinolin-2-ones." E-Journal of Chemistry 7, no. 3 (2010): 1066–70. http://dx.doi.org/10.1155/2010/317391.

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An efficient method for the synthesis of various substituted 4-methoxy-1H-quinolin-2-ones from various substituted aniline with malonic acid, phosphorous oxychloride, sodium methoxide and glacial acetic acid under different conditions is described. The title compounds were synthesized from three steps; the first step involved the synthesis of substituted 2, 4-dichloro quinoline from aniline (substituted), with malonic acid and phosphorous-oxychloride. In the second step, the substituted 2, 4 dichloro compounds was heated with freshly prepared methanolic sodium methoxide solution to give 2, 4-d
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Dissertations / Theses on the topic "Quinolic acid"

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Marques, Naiani Ferreira. "Centella asiática REDUZ PEROXIDAÇÃO LIPÍDICA INDUZIDA POR ÁCIDO QUINOLÍNICO E NITROPRUSSIATO DE SÓDIO IN VITRO EM REGIÕES DO CÉREBRO DE RATO." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/11242.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The oxidative stress is envolved in several diseases, including neurological diseases. Centella asiatica is a medicinal plant which was has long been used to treat neurological disturbances in Ayurvedic medicine. The aim of this study was to evaluate the antioxidant potencial of different extracts of C.asiatica in vitro. Were quantified by High Performance Liquid Chromatograph (HPLC) the present compounds and examined the phenolic content of the infusion and fractions: ethyl acetate, n-butanol and dichlorometane. Furthermore, the a
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Allsebrook, Andrew M. "QPRTase : quinolinic acid analogue synthesis and non-enzymic decarboxylation of N-alkylquinolinic acids." Thesis, University of St Andrews, 1998. http://hdl.handle.net/10023/14376.

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Quinolinate phosphoribosyltransferase (QPRTase, E.C. 2.4.2.19) is considered to be a unique enzyme in that it is thought to catalyse two distinct chemical reactions. Both the transfer of a phosphoribosyl group from 5-phosphoribosyl-1- pyrophosphate onto the nitrogen of quinolinic acid and the subsequent decarboxylation of the intermediate to form nicotinic acid mononucleotide are thought to be catalysed by the QPRTase system. Analogues of quinolinic acid were designed as potential inhibitors of QPRTase. These contain acidic groups at the 2- and 3- positions but are unable to decarboxylate. How
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Goes, Tiago Costa. "Efeito do enriquecimento ambiental e da lesão do cortéx pré-frontal medial nos níveis de ansiedade-traço e -estado." Universidade Federal de Sergipe, 2016. https://ri.ufs.br/handle/riufs/3614.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Effect of environmental enrichment and lesion of the medial prefrontal cortex in the trait and state anxiety levels. Tiago Costa Goes, Aracaju – SE, 2016. In the study of anxiety, there are two distinct concepts: state and trait anxiety. State anxiety is the anxiety a subject experiences at a particular moment in time, it is transitory and may be affected by external stimuli; whereas trait anxiety is considered an enduring feature of an individual, it is relatively stable over time and a predisposing factor for anxiety diso
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Morgan, Elaine M. "The role of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243084.

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Zehr, Peter S. "Synthesis of novel alkaloids using squaric acid esters." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4411.

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Thesis (Ph. D.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains xvii, 207 p. : ill. Includes abstract. Includes bibliographical references (p. 97-101).
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Miranda, Allan F. "Modulation of quinolinic acid-induced excitotoxicity by endogenous kynurenine pathway intermediates." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq22484.pdf.

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Urenjak, Jutta A., and Tihomir P. Obrenovitch. "Accumulation of quinolinic acid with euro-inflammation: does it mean excitotoxicity?" Thesis, Kluwer Academic, Plenum Publishers, New York, 2003. http://hdl.handle.net/10454/2833.

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Catton, Gemma R. "Mechanistic studies on quinolinate phosphoribosyltransferase /." St Andrews, 2007. http://hdl.handle.net/10023/485.

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Kariyawasam, Sandhya Himani. "An investigation into the biochemical changes in Tourette syndrome and associated conditions with a potential for pharmacological manipulation." Thesis, Aston University, 1999. http://publications.aston.ac.uk/10977/.

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Kynurenine (KYN) is the first stable metabolite of the kynurenine pathway, which accounts for over 95% of tryptophan metabolism. Two previous studies by this research group reported elevated plasma KYN in Tourette syndrome (TS) patients when compared with age and sex matched controls and another study showed that KYN potentiated 5-HT2A-mediated head-shakes (HS) in rodents. These movements have been suggested to model tics in TS. This raised the questions how KYN acts in eliciting this response and whether it is an action of its own or of a further metabolite along the kynurenine pathway. In th
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Heron, Paula Michelle. "An investigation of the neuroprotective effects of estrogen in a model of quinolinic acid-induced neurodegeneration." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1003237.

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The hippocampus, located in the medial temporal lobe, is an important region of the brain responsible for the formation of memory. Thus, any agent that induces stress in this area has detrimental effects and could lead to various types of dementia. Such agents include the neurotoxin, Quinolinic acid. Quinolinic acid (QUIN) is a neurotoxic metabolite of the tryptophan-kynurenine pathway and is an endogenous glutamate agonist that selectively injures and kills vulnerable neurons via the activation of the NMDA class of excitatory amino acid receptors. Estrogen is a female hormone that is responsi
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Books on the topic "Quinolic acid"

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Armstrong, Sally Fiona. Concentrations of quinolinic and kynuretic acid in patients with Alzheimer's disease and controls and their relationship to restlessness and mood states. University of Surrey Roehampton, 2000.

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W, Stone T., ed. Quinolinic acid and the kynurenines. CRC Press, 1989.

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Erickson, W. Randal. Studies on advanced intermediates in the biosynthesis of streptonigrin. 1987.

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Book chapters on the topic "Quinolic acid"

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Goda, K., R. Kishimoto, S. Shimizu, Y. Hamane, and M. Ueda. "Quinolinic Acid and Active Oxygens." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0381-7_38.

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Schwarcz, R., E. Okuno, and C. Köhler. "Endogenous Excitotoxins: Focus on Quinolinic Acid." In Excitatory Amino Acids. Palgrave Macmillan UK, 1986. http://dx.doi.org/10.1007/978-1-349-08479-1_25.

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Schwarcz, R., and F. Du. "Quinolinic Acid and Kynurenic Acid in the Mammalian Brain." In Advances in Experimental Medicine and Biology. Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5952-4_17.

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Stone, T. W., J. H. Connick, J. I. Addae, D. A. S. Smith, and P. A. Brooks. "The Neuropharmacology of Quinolinic Acid and the Kynurenines." In Excitatory Amino Acids. Palgrave Macmillan UK, 1986. http://dx.doi.org/10.1007/978-1-349-08479-1_24.

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Vezzani, A., J. B. P. Gramsbergen, C. Speciale, and R. Schwarcz. "Production of Quinolinic Acid and Kynurenic Acid by Human Glioma." In Advances in Experimental Medicine and Biology. Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5952-4_95.

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Schwarcz, R., C. Speciale, E. Okuno, E. D. French, and C. Köhler. "Quinolinic Acid: A Pathogen in Seizure Disorders?" In Advances in Experimental Medicine and Biology. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-7971-3_53.

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Guillemin, Gilles J., Kieran R. Williams, Danielle G. Smith, George A. Smythe, Juliana Croitoru-Lamoury, and Bruce J. Brew. "QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0135-0_19.

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Heyes, Melvyn P., Eugene O. Major, Kuniaki Sato, and Sanford M. Markey. "Quantification of Quinolinic Acid Metabolism by Macrophages and Astrocytes." In Technical Advances in AIDS Research in the Human Nervous System. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1949-2_23.

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da Silva, Maria Fátima das Graças Fernandes, João Batista Fernandes, Moacir Rossi Forim, Paulo Cezar Vieira, and Israel Cívico Gil de Sá. "Alkaloids Derived from Anthranilic Acid: Quinoline, Acridone, and Quinazoline." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_25.

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Okuno, E., C. Speciale, R. Schwarcz, and C. Köhler. "METABOLISM AND LOCALISATION OF QUINOLINIC ACID IN THE RAT BRAIN." In Progress in Tryptophan and Serotonin Research 1986, edited by David A. Bender, Michael H. Joseph, Walter Kochen, and Hans Steinhart. De Gruyter, 1987. http://dx.doi.org/10.1515/9783110854657-035.

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Conference papers on the topic "Quinolic acid"

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Pattanayak, Subrat Kumar. "Quantum chemical study on the NLO and NBO properties of 4-hydroxy quinoline-2-carboxylic acid." In 2ND INTERNATIONAL CONFERENCE ON CONDENSED MATTER AND APPLIED PHYSICS (ICC 2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5032823.

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Haynes, A., and P. Gouma. "Nanoengineering Polyaniline for Advanced Chemosensing Applications." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-10310.

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The focus of this study is the development of polyaniline based hybrid systems for selective room temperature detection of NO2. The electrospinning technique has been employed to produce highly dispersed nanocomposites of leucoemeraldine base polyaniline (LEB-PANI) with cellulose acetate (CA) as a secondary component. The nanocomposites exhibit sensitivity and selectivity to NO2 down to 1 ppm with response time of 70s and recovery time of 155s. Spectroscopic analyses of the nanocomposites reveal that the molecular interactions between cellulose acetate and LEB-PANI yields enhanced sensitivity
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Manabe, S., H. Yanagisawa, S. Ishikawa, et al. "TRYPTOPHAN PYROLYSIS PRODUCTS FOUND IN COOKED FOODS INHIBIT HUMAN PLATELET AGGREGATION BY INHIBITING CYCLOOXYGENASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643402.

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Humans are exposed to numerous toxic compounds in foods. During the past decade, several carcinogenic heterocyclic amines have been reported to be present in the cooked foods. Recently, we reported that some of the carcinogenic heterocyclic amines isolated from foods were present in human plasma. In order to know the effects of the carcinogens isolated from foods on the cell function, we investigated the effects of the carcinogenic heterocyclic amines including Trp-P-1(3-amino-l,4-dimethyl-5H-pyrido❘4,3-b❘indole) and Trp-P-2(3-amino-1-methyl-5H-pyrido❘4,3-b❘indole) on human platelet aggregatio
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