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Journal articles on the topic 'Quinolic acid'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Pierozan, Paula, Carolina G. Fernandes, Márcio F. Dutra, et al. "Biochemical, histopathological and behavioral alterations caused by intrastriatal administration of quinolic acid to young rats." FEBS Journal 281, no. 8 (2014): 2061–73. http://dx.doi.org/10.1111/febs.12762.

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2

Massieu, Lourdes, Natividad Rocamora, JoséMaria Palacios, and Hendrikus W. G. M. Boddeke. "Administration of quinolic acid in the rat hippocampus induces expression of c-fos and NGFI-A." Molecular Brain Research 16, no. 1-2 (1992): 88–96. http://dx.doi.org/10.1016/0169-328x(92)90197-j.

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3

Schwarzenbacher, Robert, Lukasz Jaroszewski, Frank von Delft, et al. "Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 Å resolution." Proteins: Structure, Function, and Bioinformatics 55, no. 3 (2004): 768–71. http://dx.doi.org/10.1002/prot.20029.

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4

YOKOYAMA, Takushi, Hikaru ABE, Tsutomu KURISAKI, and Hisanobu WAKITA. "13C and 27Al NMR and Potentiometric Study on the Interaction between Aluminium lons and Quinolic Acid in Acidic Aqueous Solutions." Analytical Sciences 15, no. 10 (1999): 969–72. http://dx.doi.org/10.2116/analsci.15.969.

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5

Bremner, JB, та W. Jaturonrusmee. "Manganese(III) Acetate-Induced Formation of a Fused, Chloro-Substituted β-Lactam Derivative From a Chloroacetamide". Australian Journal of Chemistry 43, № 8 (1990): 1461. http://dx.doi.org/10.1071/ch9901461.

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Reaction of 1-chloroacetyl-5-methoxy-2,3-dihydro-1H-dibenzo[de,h]quinoline (1) with manganese(III) acetate in acetic acid at 50° gave the novel fused spiro derivative 11-chloro-4-methoxy-1,2-dihydro-6H-azeto[2,1-f]dibenzo[de,h]quinoline-6,12(11H)-dione (6) in 21% yield, together with 5-methoxy-7H-dibenzo[de,h]quinolin-7-one (3), 5-methoxy-2,3-dihydro-7H-dibenzo[de,h]quinolin-7-one (4), and 1- chloroacetyl-5-methoxy-2,3-dihydro-1H-dibenzo[de,h]-quinolin-7-yl ethanoate (5) in 1, 3 and 44% yields respectively. Compound (5) was shown to be a precursor of (3), (4) and (6).

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6

Zozulynets, D. М., A. G. Kaplaushenko, and A. S. Korzhova. "The synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes." Journal of Organic and Pharmaceutical Chemistry 19, no. 1(73) (2021): 48–52. http://dx.doi.org/10.24959/ophcj.21.188137.

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Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reactionwith aldehydes.Results and discussion. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized, and a number of 4-(ethyl, aryl)idenamino derivatives were obtained on its basis.Experimental part. Using a series of four successive reactions based on quinoline-2-carboxylic acid, 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized; its interaction with aldehydes allowed to obtain a number of 4-(ethyl, aryl)idenamino derivatives. The structure of all compounds s

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7

Son, Jung-Ho, Sem Raj Tamang, Jason C. Yarbrough, and James D. Hoefelmeyer. "Hydrolysis of 8-(pinacolboranyl)quinoline: where is the 8-quinolylboronic acid?" Zeitschrift für Naturforschung B 70, no. 11 (2015): 775–81. http://dx.doi.org/10.1515/znb-2015-0031.

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AbstractThe compound 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-quinoline was prepared and found to hydrolyze rapidly in air; however, the expected product (quinolin-8-yl)boronic acid was not observed. Instead, the (quinolinium-8-yl)trihydroxyborate zwitterion or an anhydride were observed depending on the conditions of hydrolysis. The two products are related to one another in the degree of hydration, and the two forms could be interconverted. Both hydrolysis products were structurally characterized. Additionally, a commercial sample of ‘8-quinolylboronic acid’ was actually found to be t

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8

Levendis, Demetrius C., Jeffrey Moffit, Benjamin Staskun, and Theodorus van Es. "Thionyl Chloride-induced Conversion of 1-Ethyl-1,4-dihydro-2-methyl-4-oxoquinoline-3-carboxylic Acids to Highly Functionalised Thieno[3,4-b]quinoline Derivatives." Journal of Chemical Research 23, no. 10 (1999): 614–15. http://dx.doi.org/10.1177/174751989902301014.

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Warming a title acid with SOCl2 gives the corresponding 3,3,9-trichlorothieno[3,4- b]quinolin-1 (3 H)-one whereas reaction at room temperature leads to the intermediate 3,3-dichloro-4-ethylthieno[3,4- b]quinoline-1(3 H),9(4 H)-dione product as established from the respective X-ray crystallographic determinations.

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9

Li, Yang, Ming-qin Chang, Feng Gao, and Wen-tao Gao. "Facile synthesis of fused quinolines via intramolecular Friedel–Crafts acylation." Journal of Chemical Research 2008, no. 11 (2008): 640–41. http://dx.doi.org/10.3184/030823408x375070.

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The intramolecular cyclisation of 6-[(phenoxy/phenylthio)methyl][1,3]dioxolo[4,5-g]quinoline-7-carboxylic acids to [1]benzoxepino[3,4-b][1,3]dioxolo[4,5-g]quinolin-12(6H)-onesand[1]benzothiepino[3,4-b][1,3]dioxolo[4,5-g]quinolin-12(6H)-ones in the presence of Eaton's reagent (P2O5-MeSO3H) is described. This cyclisation protocol requires milder conditions than those traditionally employed and is characterised by relatively low reaction temperatures and ease of product isolation.

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10

Ramasamy, A. K., V. Balasubramaniam, and K. Mohan. "Synthesis and Characterization of Substituted 4-Methoxy-1H-quinolin-2-ones." E-Journal of Chemistry 7, no. 3 (2010): 1066–70. http://dx.doi.org/10.1155/2010/317391.

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An efficient method for the synthesis of various substituted 4-methoxy-1H-quinolin-2-ones from various substituted aniline with malonic acid, phosphorous oxychloride, sodium methoxide and glacial acetic acid under different conditions is described. The title compounds were synthesized from three steps; the first step involved the synthesis of substituted 2, 4-dichloro quinoline from aniline (substituted), with malonic acid and phosphorous-oxychloride. In the second step, the substituted 2, 4 dichloro compounds was heated with freshly prepared methanolic sodium methoxide solution to give 2, 4-d

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11

Rajpurohit, Anantacharya, Nayak D. Satyanarayan, Lokesh Pathak, Siva Ayyanar, Chidambaram R. Rishinaradamangalam, and Praveen Shoorapani. "Novel Furan Coupled Quinoline Diamide Hybrid Scaffolds as Potent Antitubercular Agents: Design, Synthesis and Molecular Modelling." Medicinal Chemistry 16, no. 4 (2020): 507–16. http://dx.doi.org/10.2174/1573406415666190904124630.

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Background: A novel series of 2-[(2-[2-(furan-2-yl) quinolin-4-yl] carbonyl hydrazinyl) carbonyl] benzoic acid, -4-oxobut-2-enoic acid and -4-oxobutanoic acids were synthesized and screened for in vitro antitubercular activity. Objectives: In the present investigation, we describe the synthesis and biological screening of furan C-2 quinoline coupled diamides for antitubercular activity. Methods: The mycobacterium tuberculai testing was carried out by MABA method and molecular docking studies were done by open-source molecular docking program, Autovina, using Pyrx 0.8 interface. Results: The re

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12

Gao, Wentao, Guihai Lin, Yang Li, Xiyue Tao, Rui Liu, and Lianjie Sun. "An efficient access to the synthesis of novel 12-phenylbenzo[6,7]oxepino[3,4-b]quinolin-13(6H)-one derivatives." Beilstein Journal of Organic Chemistry 8 (October 30, 2012): 1849–57. http://dx.doi.org/10.3762/bjoc.8.213.

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An efficient access to the tetracyclic-fused quinoline systems, 12-phenylbenzo[6,7]oxepino[3,4-b]quinolin-13(6H)-one derivatives 4a–l, is described, involving the intramolecular Friedel–Crafts acylation reaction of 2-(phenoxymethyl)-4-phenylquinoline-3-carboxylic acid derivatives 3a–l aided by the treatment with PPA (polyphosphoric acid) or Eaton’s reagent. The required starting compound (2) was obtained by Friedländer reaction of 2-aminobenzophenone (1) with 4-chloroethylacetoacetate by using CAN (cerium ammonium nitrate, 10 mol %) as catalyst at room temperature. The substrates 3a–l were pre

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13

Fedorowicz, Joanna, Karol Gzella, Paulina Wiśniewska, and Jarosław Sączewski. "2,2′-((1,4-Dimethoxy-1,4-dioxobutane-2,3-diylidene)bis(azanylylidene))bis(quinoline-3-carboxylic acid)." Molbank 2019, no. 4 (2019): M1093. http://dx.doi.org/10.3390/m1093.

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The title compound, 2,2′-((1,4-dimethoxy-1,4-dioxobutane-2,3-diylidene)bis(azanylylidene))bis(quinoline-3-carboxylic acid) was synthesized from isoxazolo[3,4-b]quinolin-3(1H)-one and dimethyl acetylenedicarboxylate (DMAD) via a double aza-Michael addition followed by [1,3]-H shifts. The product was characterized by infrared and nuclear magnetic resonance spectroscopy, as well as elemental analysis and high-resolution mass spectrometry (HRMS). The proposed reaction mechanism was rationalized by density functional theory (DFT) calculations.

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14

Fang, Guiqian, Hao Wang, Zhancun Bian, et al. "2-(4-Boronophenyl)quinoline-4-carboxylic acid derivatives: Design and synthesis, aggregation-induced emission characteristics, and binding activity studies for D-ribose with long-wavelength emission." Journal of Chemical Research 44, no. 3-4 (2019): 152–60. http://dx.doi.org/10.1177/1747519819893642.

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Long-wavelength fluorescent sensors with large Stokes shifts show useful applications in chemical biology and clinical laboratory diagnosis. We have recently reported [4-(4-{[3-(4-boronobenzamido)propyl]carbamoyl}quinolin-2-yl)phenyl]boronic acid that can selectively recognize d-ribose in a buffer solution of pH 7.4. However, the short emission wavelength (395 nm) and aggregation-caused quenching effect are not conducive to applications as a sensor. Novel diboronic acid compounds are synthesized using 2-(4-boronophenyl)quinoline-4-carboxylic acid as the building block and p-phenylenediamine as

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15

Blesl, C., A. Tmava, A. Baranyi, et al. "The Kynurenine pathway in pancreatic carcinoma." European Psychiatry 41, S1 (2017): S480. http://dx.doi.org/10.1016/j.eurpsy.2017.01.564.

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IntroductionPancreatic carcinoma (PC) belongs to the most aggressive tumours worldwide, with a five year survival of 7%. Mostly, diagnosis is made in late stages, as by now no early detection method is available. Symptoms of depression occur frequently before diagnosis of PC. PC and depression are both known to go along with changes in the kynurenine-pathway.ObjectivesThis study aimed to examine the kynurenine pathway (Figure 1) and evaluate a possible depression in newly diagnosed PC patients in comparison to healthy controls (HC).Methods26 PC patients and 26 age and sex matched HC participat

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16

Idrees, M., Y. G. Bodkhe, N. J. Siddiqui, and S. S. Kola. "Synthesis, Characterization and in vitro Antimicrobial Screening of Some Novel Series of 2-Azetidinone Derivatives Integrated with Quinoline, Pyrazole and Benzofuran Moieties." Asian Journal of Chemistry 32, no. 4 (2020): 896–900. http://dx.doi.org/10.14233/ajchem.2020.22490.

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A series of 5-(benzofuran-2-yl)-N-(3-chloro-4-(2-(p-tolyloxy) substituted quinolin-3-yl)-2-oxoazetidin-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (4a-f) were synthesized with excellent yields by cyclocondensation reaction of 5-(benzofuran-2-yl)-N′-(2-(p-tolyloxy) substituted quinolin-3-yl)methylene)-1-phenyl-1H-pyrazole-3-carbohydrazide (3a-f) with chloroacetyl chloride in presence of triethylamine in DMF. One pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with 2-(p-tolyloxy) substituted quinoline-3-carbaldehyde (2a-f) in ethanol solvent in presence

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17

Heyes, Melvyn P., and Thaddeus S. Nowak. "Delayed Increases in Regional Brain Quinolinic Acid Follow Transient Ischemia in the Gerbil." Journal of Cerebral Blood Flow & Metabolism 10, no. 5 (1990): 660–67. http://dx.doi.org/10.1038/jcbfm.1990.119.

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Excessive activity or release of excitatory amino acids has been implicated in the neuronal injury that follows transient cerebral ischemia. To investigate the metabolism of the endogenous excitotoxin, quinolinic acid, and its potential for mediating cell loss following ischemia, the concentrations of quinolinic acid, L-tryptophan, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid were quantified in gerbil brain regions at different times after 5 or 15 min of ischemia induced by bilateral carotid artery occlusion. Significant elevation of brain tryptophan levels, accompanied by increased 5-h

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18

Deady, Leslie W., and Clare L. Smith. "Tetracycle Formation from the Reaction of Acetophenones with 1-Aminoanthraquinone, and Further Annulation of Pyridine and Diazepine Rings." Australian Journal of Chemistry 56, no. 12 (2003): 1219. http://dx.doi.org/10.1071/ch03136.

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Acetophenones (H, o-, m-, p-Cl, o-aza) react with aminoanthraquinone in pyridine containing solid sodium hydroxide to form 6-(arylcarbonyl)methyl-2-aryl-7H-naphtho[1,2,3-de]quinolin-7-ones (with the 4-(arylcarbonyl)methyl isomer as minor product). Preformed 7H-benzo[e]perimidin-7-one with acetophenone underwent the second part of this process, i.e. nucleophilic substitution to form 6-phenacyl-7H-benzo-[e]perimidin-7-one. Further reactions are described, including cyclization with ammonium acetate/acetic acid to 2,7-diphenyl-1,6-diazabenzo[e]pyrene and 7-phenyl-1,3,8-triazabenzo[e]pyrene, respe

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19

Hadanu, Ruslin, Chairil Anwar, Jumina Jumina, Iqmal Tahir, and Mustofa Mustofa. "SYNTHESIS OF ANTIMALARIAL 3-(2-HYDROXYETHYL)-2-METHYL-1,10-PHENANTHROLINE-4-OL FROM 8-AMINOQUINOLINE." Indonesian Journal of Chemistry 4, no. 2 (2010): 82–87. http://dx.doi.org/10.22146/ijc.21858.

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It has been conducted the synthesis of 3-(2-hydroxyethyl)-2-methyl-1,10-phenanthroline-4-ol was carried out from 8-aminoquinoline which are expected to posses antimalarial activity. The experiment perfomed consisted of two steps i.e (1) reaction of 8-aminoquinoline with 2-acetyl-butyrolactone and (2) cyclization of the resulted 3-[1-(quinolin-8-ylamino)-ethylidene]-4,5-dihydro-furan-2-one. The reaction of 8-aminoquinoline with 2-acetyl-butyrolactone was performed in toluene at reflux for 6 hours in the presence of p-toluensulfonic acid as catalyst. This reaction gave 3-[1-(quinolin-8-ilamino)-

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20

Zhang, Chi, Juan Huang, Wei Wei, and Zhengbo Chen. "Colorimetric identification of lanthanide ions based on two carboxylic acids as an artificial tongue." Analyst 145, no. 9 (2020): 3359–63. http://dx.doi.org/10.1039/d0an00357c.

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21

Kuchař, Miroslav, Bohumila Brunová, Richard Junek, et al. "The Antileukotrienic Derivatives and Homologues of [(Quinolin-2-ylmethoxy)sulfanyl]benzoic Acids with Reduced Lipophilicity." Collection of Czechoslovak Chemical Communications 70, no. 9 (2005): 1357–71. http://dx.doi.org/10.1135/cccc20051357.

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A series of ({[(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)acetic acids 2 and S-oxidized derivatives of {[(quinolin-2-ylmethoxy)phenyl]sulfanyl}benzoic acids 3 were prepared and their antileukotrienic and antiasthmatic activities evaluated. Regression analysis led to the conclusion that the antileukotrienic activities of compounds 2 correspond to the relationships between these activities and lipophilicity, derived for the previously synthesized series of substituted (arylsulfanyl)benzoic acids 1A, 1B and 1C. Acids 3 are outliers from these relationships, probably due to a somewhat different

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22

Zhang, Yu-Mei, Ning-Hua Tan, Huo-Qiang Huang, and Guang-Zhi Zeng. "Triterpenoid Saponins from Metadina trichotoma." Zeitschrift für Naturforschung B 62, no. 5 (2007): 745–48. http://dx.doi.org/10.1515/znb-2007-0521.

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Abstract Two new 27-nor-triterpene glycosides, pyrocincholic acid 3β -O-β -D-glucopyranosyl-(1→4)- β -D-quinovopyranosyl-28-O-β -D-glucopyranoside (Metatrichoside A, 1), pyrocincholic acid 3β -O-β -D-glucopyranosyl-(1→4)-β -D-quinovopyranosyl-28-O-β -D-glucopyranosyl-(1→6)-β -Dglucopyranoside (Metatrichoside B, 2), together with pyrocincholic acid 3β -O-β -D-quinovopyranosyl- 28-O-β -D-glucopyranoside (3), pyrocincholic acid 3β -O-β -D-quinovopyranosyl-28-O-β -Dglucopyranosyl-( 1→6)-β -D-glucopyranoside (4), quinovic acid 3β -O-β -D-quinovopyranoside (5), quinovic acid 3β -O-β -D-quinovopyrano

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23

Sahu, Niranjan P., Kazuo Koike, Zhonghua Jia, Sukdeb Banerjee, Nirup B. Mandal, and Tamotsu Nikaido. "Triterpene Glycosides from the Bark of Anthocephalus Cadamba." Journal of Chemical Research 2000, no. 1 (2000): 22–23. http://dx.doi.org/10.3184/030823400103165536.

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Two triterpenoid glycosides, glycosides A and B were isolated from the bark of Anthocephalus cadamba and defined as 3- O-[α-L-rhamnopyranosyl]-quinovic acid-28- O-[β-D-glucopyranosyl] ester and 3- O-[β-D-glucopyranosyl]-quinovic acid-28- O-[β-D-glucopyranosyl] ester respectively.

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24

Habashneh, Almeqdad Y., Mustafa M. El-Abadelah, Mohammad S. Mubarak, and Wolfgang Voelter. "Heterocycles [f]-Fused onto Quinolones. Synthesis of Novel Dioxo-Nethylpyrano[ 2,3-f ]- and [3,2-f ]quinoline-10-carboxylic Acids." Zeitschrift für Naturforschung B 68, no. 9 (2013): 1049–55. http://dx.doi.org/10.5560/znb.2013-3122.

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A model N-ethyl-1,10-dioxo-3-phenylpyrano[3,2- f ]quinoline-9-carboxylic acid (8) and the isomeric (2-substituted) pyrano[2,3- f ]quinoline-9-carboxylic acids (6 and 7) were prepared from the corresponding 6/7-aminochromen-4-ones via the Gould-Jacobs reaction. The new tricyclic heterocycles 6-8 exhibit moderate antibacterial activity (MIC=16 - 64 μgmL-1) against E. coli and S. aureus

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25

Sinz, Elizabeth H., Patrick M. Kochanek, Melvyn P. Heyes, et al. "Quinolinic Acid is Increased in CSF and Associated with Mortality after Traumatic Brain Injury in Humans." Journal of Cerebral Blood Flow & Metabolism 18, no. 6 (1998): 610–15. http://dx.doi.org/10.1097/00004647-199806000-00002.

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We tested the hypothesis that quinolinic acid, a tryptophan-derived N-methyl-d-aspartate agonist produced by macrophages and microglia, would be increased in CSF after severe traumatic brain injury (TBI) in humans, and that this increase would be associated with outcome. We also sought to determine whether therapeutic hypothermia reduced CSF quinolinic acid after injury. Samples of CSF ( n = 230) were collected from ventricular catheters in 39 patients (16 to 73 years old) during the first week after TBI, (Glasgow Coma Scale [GCS] < 8). As part of an ongoing study, patients were randomized

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26

HEYES, Melvyn P., Cristian L. ACHIM, Clayton A. WILEY, Eugene O. MAJOR, Kuniaki SAITO, and Sanford P. MARKEY. "Human microglia convert l-tryptophan into the neurotoxin quinolinic acid." Biochemical Journal 320, no. 2 (1996): 595–97. http://dx.doi.org/10.1042/bj3200595.

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Immune activation leads to accumulations of the neurotoxin and kynurenine pathway metabolite quinolinic acid within the central nervous system of human patients. Whereas macrophages can convert l-tryptophan to quinolinic acid, it is not known whether human brain microglia can synthesize quinolinic acid. Human microglia, peripheral blood macrophages and cultures of human fetal brain cells (astrocytes and neurons) were incubated with [13C6]l-tryptophan in the absence or presence of interferon γ. [13C6]Quinolinic acid was identified and quantified by gas chromatography and electron-capture negati

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27

Ohashi, Kazuto, Shigeyuki Kawai, and Kousaku Murata. "Secretion of Quinolinic Acid, an Intermediate in the Kynurenine Pathway, for Utilization in NAD + Biosynthesis in the Yeast Saccharomyces cerevisiae." Eukaryotic Cell 12, no. 5 (2013): 648–53. http://dx.doi.org/10.1128/ec.00339-12.

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ABSTRACT NAD + is synthesized from tryptophan either via the kynurenine ( de novo ) pathway or via the salvage pathway by reutilizing intermediates such as nicotinic acid or nicotinamide ribose. Quinolinic acid is an intermediate in the kynurenine pathway. We have discovered that the budding yeast Saccharomyces cerevisiae secretes quinolinic acid into the medium and also utilizes extracellular quinolinic acid as a novel NAD + precursor. We provide evidence that extracellular quinolinic acid enters the cell via Tna1, a high-affinity nicotinic acid permease, and thereby helps to increase the int

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Niwa, Toshlmitsu, Hldeo Yoshizumi, Yutaka Emoto, et al. "Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis." Clinical Chemistry 37, no. 2 (1991): 159–61. http://dx.doi.org/10.1093/clinchem/37.2.159.

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Abstract Quinolinic acid was first identified in uremic serum by use of gas chromatography/mass spectrometry. Quantification by selected ion monitoring revealed that the serum concentration of quinolinic acid was markedly increased in chronic hemodialysis patients, and that the acid could be removed by conventional hemodialysis. The serum concentration of quinolinic acid was weakly but significantly correlated with the serum uric acid concentration. Accumulation of quinolinic acid in uremic blood may be involved in the pathogenesis of anemia, suppressed immune system, and uremic encephalopathy

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29

Gaber, Ahmed, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Ibrahim M. El-Deen, and Moamen S. Refat. "Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs." Crystals 11, no. 5 (2021): 565. http://dx.doi.org/10.3390/cryst11050565.

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This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst to give ethyl coumarin-3-carboxylate, followed by the ammonolysis of ester (ethyl coumarin-3-carboxylate) with ammonia in the presence of anhydrous potassium carbonate. Treatment of 2-oxo-1H-quinoline-3-carboxylic acid with acetic anhydride, cinnamaldehyde, cinnamic acid and methyl 5-phenyl-2-cyano-2,4-pentadienoat

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30

Xu, Jingjing, Ziqiao Ding, Bing Liu, et al. "Structure of the cytochrome aa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site." Proceedings of the National Academy of Sciences 117, no. 2 (2019): 872–76. http://dx.doi.org/10.1073/pnas.1915013117.

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Virtually all proton-pumping terminal respiratory oxygen reductases are members of the heme-copper oxidoreductase superfamily. Most of these enzymes use reduced cytochrome c as a source of electrons, but a group of enzymes have evolved to directly oxidize membrane-bound quinols, usually menaquinol or ubiquinol. All of the quinol oxidases have an additional transmembrane helix (TM0) in subunit I that is not present in the related cytochrome c oxidases. The current work reports the 3.6-Å-resolution X-ray structure of the cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis containing 1 e

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31

Bankeu, Jean J. K., Stéphanie Madjouka, Guy R. T. Feuya, et al. "Pobeguinine: a monoterpene indole alkaloid and other bioactive constituents from the stem bark of Nauclea pobeguinii." Zeitschrift für Naturforschung C 73, no. 9-10 (2018): 335–44. http://dx.doi.org/10.1515/znc-2017-0127.

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AbstractPhytochemical investigation of dichloromethane neutral phase of stem bark ofNauclea pobeguiniiled to the isolation of a new monoterpene indole alkaloid, pobeguinine1along with 14 known compounds including (−)-naucleofficine D (2a), (+)-naucleofficine D (2b), naucleidinal (3), quafrinoic acid (4), betulinic acid (5), ursolic acid (6), quinovic acid (7), quinovic acid 3-O-α-L-rhamnopyranoside (8a), quinovic acid 3-O-β-D-fucopyranoside (8b), β-sitosterol (9), β-sitosterol 3-O-β-D-glucopyranoside (10), benzoic acid (11), lacceroic acid (12) andn-heptacosane (13). The structure of compound1

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Anjana, S. S., Babu Varghese, and Edamana Prasad. "Dinuclear cobalt(II) complexes with double phosphate ester bridges and tetradentate ligands having anisole or quinoline appendages." Acta Crystallographica Section C Structural Chemistry 73, no. 6 (2017): 492–97. http://dx.doi.org/10.1107/s2053229617007355.

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Phosphate esters provide a rigid and stable polymeric backbone in nucleic acids. Metal complexes with phosphate ester groups have been synthesized as structural and spectroscopic models of phosphate-containing enzymes. Dinucleating ligands are used extensively to synthesize model complexes since they provide the support required to stabilize such complexes. The crystal structures of two dinuclear CoII complexes, namely bis(μ-diphenyl phosphato-κ2 O:O′)bis({2-methoxy-N,N-bis[(pyridin-2-yl)methyl]aniline-κ4 N,N′,N′′,O}cobalt(II)) bis(perchlorate), [Co(C12H10O4P)2(C19H19N3O)2](ClO4)2, and bis(μ-d

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Singla, Rajeev K., and Bairong Shen. "In Silico ADMET Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes." Current Drug Metabolism 21, no. 10 (2020): 768–77. http://dx.doi.org/10.2174/1389200221999200901202945.

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Background: As a metabolic and lifestyle disorder, diabetes mellitus poses a prodigious health risk. Out of the many key targets, DPP-IV is one of the very imperative therapeutic targets for the treatment of diabetic patients. Methods: In our current study, we have done the in silico simulations of ADME-T properties for naturally originated potent DPP-IV inhibitors like quinovic acid, stigmasterol, quinovic acid-3-beta-D-glycopyranoside, zygophyloside E, and lupeol. Structural topographies associated with different pharmacokinetic properties have been systematically assessed. Results: Glycosyl

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Guillemin, Gilles J. "Quinolinic acid: neurotoxicity." FEBS Journal 279, no. 8 (2012): 1355. http://dx.doi.org/10.1111/j.1742-4658.2012.08493.x.

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Lamidi, M., E. Ollivier, R. Faure, L. Debrauwer, L. Nze-Ekekang, and G. Balansard. "Quinovic Acid Glycosides fromNauclea diderrichii." Planta Medica 61, no. 03 (1995): 280–81. http://dx.doi.org/10.1055/s-2006-958075.

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Ma, Xiangjuan, Lixia Bian, Jingfeng Ding, Yaping Wu, Huilong Xia та Jionghui Li. "Electrochemical oxidation of quinoline aqueous solution on β-PbO2 anode and the evolution of phytotoxicity on duckweed". Water Science and Technology 75, № 8 (2017): 1820–29. http://dx.doi.org/10.2166/wst.2017.053.

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Electrochemical oxidation of quinoline on a β-PbO2 electrode modified with fluoride resin and the comprehensive toxicity of intermediates formed during oxidation on duckweed were investigated in detail. The results showed that quinoline was initially hydroxylated at the C-2 and C-8 positions by hydroxyl radicals (·OH) electro-generated on a β-PbO2 anode, yielding 2(1H)-quinolinone and 8-hydroxyquinoline, then undergoing ring cleavage to form pyridine, nicotinic acid, pyridine-2-carboxaldehyde and acetophenone, which were ultimately converted to biodegradable organic acids. NO3− was the final f

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Abd El-Aal, Hassan A. K., and Talaat I. El-Emary. "Synthesis of Tetracyclic Fused Quinolines via a Friedel–Crafts and Beckmann Ring Expansion Sequence." Australian Journal of Chemistry 72, no. 12 (2019): 945. http://dx.doi.org/10.1071/ch19363.

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An efficient protocol for the construction of tetracyclic fused quinolines (pyrazole-fused azepino-, azocino-, and azonino[3,2-b]quinolinones) via consecutive Friedel–Crafts and Beckmann reactions has been developed. The key steps in the syntheses of these new molecular scaffolds involve acid-mediated cyclization of 2-(pyrazol-3-yl)quinoline based carboxylic acids 6a–c, 8, and 12 to ketones 13a–e, followed by Beckmann rearrangements of the corresponding oximes 14a–e to provide the tetracyclic-fused quinoline skeletons 15a–e. Structures of synthesised compounds without stereochemical implicatio

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Abd El-Aal, Hassan A. K., and Talaat I. El-Emary. "Corrigendum to: Synthesis of Tetracyclic Fused Quinolines via a Friedel–Crafts and Beckmann Ring Expansion Sequence." Australian Journal of Chemistry 72, no. 12 (2019): 990. http://dx.doi.org/10.1071/ch19363_co.

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An efficient protocol for the construction of tetracyclic fused quinolines (pyrazole-fused azepino-, azocino-, and azonino[3,2-b]quinolinones) via consecutive Friedel–Crafts and Beckmann reactions has been developed. The key steps in the syntheses of these new molecular scaffolds involve acid-mediated cyclization of 2-(pyrazol-3-yl)quinoline based carboxylic acids 6a–c, 8, and 12 to ketones 13a–e, followed by Beckmann rearrangements of the corresponding oximes 14a–e to provide the tetracyclic-fused quinoline skeletons 15a–e. Structures of synthesised compounds without stereochemical implicatio

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Egashira, Sato, Saito, and Sanada. "Dietary Protein Level and Dietary Interaction Affect Quinolinic Acid Concentration in Rats." International Journal for Vitamin and Nutrition Research 77, no. 2 (2007): 142–48. http://dx.doi.org/10.1024/0300-9831.77.2.142.

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During tryptophan-niacin conversion, hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) [EC4.1.1.45] plays a key role in regulating NAD biosynthesis. ACMSD activity is greatly affected by many factors such as nutritional status and disease. The tryptophan catabolite quinolinic acid has been reported to be associated with the pathogenesis of various disorders and is a potential endogenous toxin. However the effects of dietary protein levels or dietary interaction between protein levels and fatty acid type to this process have not been investigated and are still unknown. In t

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Saito, K., C. Y. Chen, M. Masana, J. S. Crowley, S. P. Markey та M. P. Heyes. "4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells)". Biochemical Journal 291, № 1 (1993): 11–14. http://dx.doi.org/10.1042/bj2910011.

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Accumulation of quinolinic acid and L-kynurenine occurs in the brain and/or blood following immune activation, and may derive from L-tryptophan following induction of indoleamine 2,3-dioxygenase and other kynurenine-pathway enzymes. In the present study a survey of various cell lines derived from either brain or systemic tissues showed that, while all cells examined responded to interferon-gamma by increased conversion of L-[13C6]tryptophan into L-kynurenine (human: B-lymphocytes, neuroblastoma, glioblastoma, lung, liver, kidney; rat brain: microglia, astrocytes and oligodendrocytes), only mac

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Heyes, Melvyn P. "Hypothesis: A Role for Quinolinic Acid in the Neuropathology of Glutaric Aciduria Type I." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, S3 (1987): 441–43. http://dx.doi.org/10.1017/s0317167100037872.

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ABSTRACT:Glutaric aciduria type I is an autosomal recessive metabolic disorder of children associated with severe dystonic motor disturbances and degeneration in the cerebral cortex, striatum and cerebellum. Biochemical studies demonstrate a deficiency in the enzyme glutaryl-CoA dehydrogenase. This enzyme metabolizes substrate derived from dietary tryptophan that could otherwise be converted to quinolinic acid within the brain. The law of mass action predicts that the production of quinolinic acid should be increased in glutaric aciduria type I. Quinolinic acid is a potent neurotoxin and convu

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Rudzite, Vera, Edite Jurika, Janis Jirgensons, et al. "The Influence of Kynurenine and Its Metabolites on Lipid Metabolism." Pteridines 8, no. 3 (1997): 201–5. http://dx.doi.org/10.1515/pteridines.1997.8.3.201.

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Summary Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol. The addition of L-kynurenine (4 nmoljg wet weight) to incubation medium induced an increase of palmitic, oleic and linolenic acid and decrease of linoleic and arachidonic acid incorporation into phospholipids. These changes of fatty acid incorporation into phospholipids were followed by increase of cholesterol and decrease of phospholipids content in samples. The addition of 3

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Abd El-Aal, Hassan A. K. "Friedel–Crafts Chemistry. Part 48. Concise Synthesis of Condensed Azaheterocyclic [1,8]naphthyridinones, Azepino-, Azocino-, and Azoninoquinoline Systems via Friedel–Crafts Ring Closures." Australian Journal of Chemistry 70, no. 10 (2017): 1082. http://dx.doi.org/10.1071/ch17108.

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Unprecedented construction of a novel series of quinoline heteropolycycles (tetracyclic keto-analogues of [1,8]naphthyridinones, azepino-, azocino- and azonino[2,3-b]quinolinones systems) 10a–i by Friedel–Crafts cycliacylation reactions is described. Starting heterocyclic acids precursors 3a–i were prepared from easily accessible 2-chloroquinoline-3-carbaldehyde 1 via a three different synthetic pathways. Acid-catalyzed ring closures of the resulting tosylated acids were achieved under the influence of both Brønsted and Lewis acid catalysts. The present strategy enables a straightforward synth

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Dixit, Satish C., and Rohit K. Singh. "Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids." E-Journal of Chemistry 9, no. 2 (2012): 744–48. http://dx.doi.org/10.1155/2012/631391.

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Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acidsviz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried out in different stoichiometric ratios. Complexes of the type Cp2Zr(QAH)Cl, Cp2Zr(QAH)2, Cp2Zr(PAH)Cl, Cp2Zr(PAH)2, Cp2Zr(IAH)Cl, Cp2Zr(IAH)2, Cp2Zr(CAH)Cl, Cp2Zr(CAH)2, Cp2Zr(DAH)Cl and Cp2Zr(DAH)2were obtained. These new complexes were characterized on the basis of their elemental analyses, electrical conductance, magnetic moment and spectral

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Maksimovic, Ivana, Marina Jovanovic, Miodrag Colic, Dejan Micic, Rosa Mihajlovic, and Vesna Selakovic. "Nitric oxide synthase inhibitors prevents quinolinic acid-induced neurotoxicity: the role of nitric oxide and glucose-6-phosphate dehydrogenase in cell death." Jugoslovenska medicinska biohemija 21, no. 3 (2002): 269–74. http://dx.doi.org/10.2298/jmh0203269m.

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In the present study we employed Nw-nitro-L-arginine methyl ester, non-specific potent nitric oxide synthase inhibitor and a selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reportedly to investigate the possible involvement of nitric oxide in quinolinic acid-induced striatal toxicity in the rat. Quinolinic acid was administered unilaterally into striatum of adult Wistar rats in the single dose of 150 nmol/L. The other two group of animals were pretreated with Nw-nitro-L-arginine methyl ester and 7-nitroindazole respectively. Control groups of animals were treated with 0

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Ata, Athar, Chibuike C. Udenigwe, Wadim Matochko, Paul Holloway, Michael O. Eze, and Peter N. Uzoegwu. "Chemical Constituents of Nauclea latifolia and their Anti-GST and Anti-Fungal Activities." Natural Product Communications 4, no. 9 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400905.

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The crude ethanolic extract of Nauclea latifolia yielded five known compounds, strictosamide (1), naucleamides A (2), naucleamide F (3), quinovic acid-3-O-β-rhamnosylpyranoside (4), and quinovic acid 3-O-β-fucosylpyranoside (5). Microbial reactions, using a whole cell culture of Rhizopus circinans on compound (1), yielded three analogues, 10-hydroxystrictosamide (6), 10-4bT-glucosyloxyvincoside lactam (7) and 16,17-dihydro-10-β-glucosyloxyvincoside lactam (8). Compounds 1-8 were identified with the aid of extensive NMR spectral studies. Compound 8 was found to be a new metabolite. Compounds 1-

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Калиновская, И. В. "Люминесцентные свойства соединений европия(III) с хинолиновой кислотой и фосфорсодержащими нейтральными лигандами". Журнал технической физики 127, № 8 (2019): 231. http://dx.doi.org/10.21883/os.2019.08.48034.332-18.

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AbstractLuminescent mixed-ligand europium(III) complexes with quinolinic acid and phosphorus-containing neutral ligands with a dimeric structure of the composition Eu_2(QA)_3 · 3Н_2О, Eu_2(QA)_3 · D · 2Н_2О, where QA is quinolinic acid and D is hmpa (hexamethylphosphortriamide), tppo (triphenylphosphinoxide), (hmpa), or Et_6pa (hexaethylphosphortriamide), are synthesized. The thermal and spectral-luminescent properties of the synthesized complex mixed-ligand europium(III) compounds are studied. It is shown that the detachment of water and neutral ligand molecules during thermolysis occurs in t

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Nishizaki, Daisuke, and Hideo Iwahashi. "Baicalin Inhibits the Fenton Reaction by Enhancing Electron Transfer from Fe2+ to Dissolved Oxygen." American Journal of Chinese Medicine 43, no. 01 (2015): 87–101. http://dx.doi.org/10.1142/s0192415x15500068.

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Sho-saiko-to is an herbal medicine that is known to have diverse pharmacological activities and has been used for the treatment of various infectious diseases. Here, we examined the effects of baicalin, a compound isolated from Sho-saiko-to, and the effects of the iron chelator quinolinic acid on the Fenton reaction. The control reaction mixture contained 0.1 M 5,5-dimethyl-1-pyrroline N-oxide (DMPO), 0.2 mM H 2 O 2, 0.2 mM FeSO 4( NH 4)2 SO 4, and 40 mM sodium phosphate buffer (pH 7.4). Upon the addition of 0.6 mM baicalin or quinolinic acid to the control reaction mixture, the ESR peak heigh

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Mohamed, Mahmoud. "Quinovic acid glycosides from Zygophyllum aegyptium." Bulletin of Pharmaceutical Sciences. Assiut 22, no. 1 (1999): 47–53. http://dx.doi.org/10.21608/bfsa.1999.66076.

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Matos, M. E. O., M. P. Sousa, M. L. L. Machado, and R. Braz Filho. "Quinovic acid glycosides from Guettarda angelica." Phytochemistry 25, no. 6 (1986): 1419–22. http://dx.doi.org/10.1016/s0031-9422(00)81301-1.

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