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Journal articles on the topic 'Quinoline ring derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Shoji, Taku, Mutsumi Takeuchi, Mayumi Uda, et al. "Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes." Molecules 28, no. 15 (2023): 5785. http://dx.doi.org/10.3390/molecules28155785.

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Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which are readily prepared via the aromatic nucleophilic substitution reaction of a 2-chloroazulene derivative with several arylamines. The synthesis of azuleno[2,1-b]quinolones was established by the Brønsted acid-catalyzed intramolecular cyclization of 2-arylaminoazulene derivatives bearing two ester groups at the five-membered ring. The halogenat

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2

Rogerio, Kamilla Rodrigues, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, et al. "Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum." Current Topics in Medicinal Chemistry 20, no. 2 (2020): 99–110. http://dx.doi.org/10.2174/1568026619666191019100711.

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Introduction: In this work DHPMs were combined with the quinoline nucleus to obtain new quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione compounds with improved antiplasmodial activity as well as decreased cytotoxicity. Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinolone ring moieties with different substituents were synthesized and assayed against P. falciparum. Materials and Methods: Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinoline ring moieties with different substituents were syn

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3

Zhang, Xiaofeng, Miao Liu, Weiqi Qiu, and Wei Zhang. "2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives." Molecules 29, no. 6 (2024): 1241. http://dx.doi.org/10.3390/molecules29061241.

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Quinoline is a privileged heterocyclic ring which can be found in many drug molecules and bioactive compounds. The development of synthetic methods for making quinoline derivatives continuously attracts the interest of organic and medicinal chemists. This paper highlights 2-azidobenzaldehyde-based [4+2] annulation for the synthesis of quinoline derivatives including fused and spiro-quinolines, quinoline-4-ols, 4-aminoquinolines, and related compounds.

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4

Srinivas, Sangu*and Anil Kumar Middha. "SYNTHESIS, ANTI MICROBIAL, ANTI CANCER EVALUTION AND MOLECULAR DOCKING STUDIES OF QUINAZOLINYL THIADIAZOLES DERIVATIVES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 11458–65. https://doi.org/10.5281/zenodo.1477785.

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<em>Quinazoline derivatives are reported to have anti microbial, anti inflammatory, analgesic and anti cancer activities. The incorporated oxymethyl carbamide at 4<sup>th</sup> position of the quinoline ring was found to influence the biological activities of the molecules with this some of new Quinolinyl- oxymethyl -thiadiazoles synthesized from 4-hydroxy quinoline through (quinolin-4yloxy) acetyl hydrazide intermediates. All the synthesized compounds were characterized by IR, H<sup>1</sup>NMR spectral data and carried out molecular docking studies against calcium/calmoduline dependent protei

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5

Khidre, Rizk E., Ibrahim Ali M. Radini, and Diaa A. Ibrahim. "Synthetic Approaches of Pyrazolyl Quinolines." Mini-Reviews in Organic Chemistry 16, no. 4 (2019): 353–60. http://dx.doi.org/10.2174/1570193x15666180419142511.

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This review article represents a survey of the synthetic strategies leading to pyrazolyl quinolines. The synthetic methods are divided into two main groups based on the type of starting reagents: 1) From quinoline ring onto a pyrazole scaffold, 2) From pyrazole ring onto a quinoline scaffold. Also, some medical applications of pyrazolyl quinoline derivatives are mentioned such as anticancer, cell proliferative disorder, glucose transport inhibitors, anti-inflammatory, and inhibitors of leukotriene production for the treatment of cardiovascular. The main purpose of this review is to present a s

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6

Garudachari, Bhadrachari, and Arun Mohan Isloor. "Substituted Quinoline Derivatives as Potent Biological Agents." Advanced Materials Research 995 (July 2014): 61–84. http://dx.doi.org/10.4028/www.scientific.net/amr.995.61.

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Quinoline derivatives are the most promising class of active pharmaceutical agents compared with other heterocyclic compounds. Biological activity profile of quinoline can easily be controlled by introducing some active pharmacophore to the core ring. This chapter deals with the synthesis of quinoline derivatives and its biological activity. The enhancement of biological activity by incorporation of active functional group and effect of these functional groups were explained briefly. Main focus is given to the synthesis of different substituted quinoline derivatives for biological application

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7

Swapna, Sahu, Srivastava Shobhit, and Kumar Gupta Sujeet. "A Review on Quinoline: Diverse Pharmacological Agent." Chemistry Research Journal 6, no. 4 (2021): 81–96. https://doi.org/10.5281/zenodo.11666866.

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<strong>Abstract </strong>Quinoline is a heterocyclic aromatic organic & fused ring compound with the Chemical formula C<sub>9</sub>H<sub>7</sub>N.  Quinoline is an important pharmacophore in medicinal chemistry, since a large number of its derivatives possess useful biological properties. Also, Quinolones are known for their formation of conjugated molecules and polymers that combine enhanced electronic, optoelectronic, or nonlinear optical properties with excellent mechanical properties. They have a crucial role in the synthesis of various new therapeutic agents. For new drug develo

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8

Nyamwihura, Rogers J., Huaisheng Zhang, Jasmine T. Collins, Olamide Crown, and Ifedayo Victor Ogungbe. "Nopol-Based Quinoline Derivatives as Antiplasmodial Agents." Molecules 26, no. 4 (2021): 1008. http://dx.doi.org/10.3390/molecules26041008.

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Malaria remains a significant cause of morbidity and mortality in Sub-Saharan Africa and South Asia. While clinical antimalarials are efficacious when administered according to local guidelines, resistance to every class of antimalarials is a persistent problem. There is a constant need for new antimalarial therapeutics that complement parasite control strategies to combat malaria, especially in the tropics. In this work, nopol-based quinoline derivatives were investigated for their inhibitory activity against Plasmodium falciparum, one of the parasites that cause malaria. The nopyl-quinolin-8

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9

Ambatkar, Megha P., and Pramod B. Khedekar. "Quinoline as TRPV1 Antagonists: A New Approach against Inflammation." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 782–88. http://dx.doi.org/10.22270/jddt.v9i4-s.3414.

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Inflammation is the first response of the immune system to harmful stimuli such as infection or irritation, consists of a cascade of biochemical events that propagates and matures the inflammatory response. Number of anti-inflammatory drugs are available for treatment of acute and chronic inflammation. Many anti-inflammatory drugs cause adverse side effects. The quinoline class of compounds are important for searching the safe and effective anti-inflammatory drugs. These drugs are classified based on the number of substituents present on the quinoline ring or compounds containing a quinoline r

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10

Abelt, Christopher, Ian Day, Junkai Zhao, and Robert Pike. "Fluorescence of Half-Twisted 10-Acyl-1-methyltetrahydrobenzoquinolines." Molecules 29, no. 13 (2024): 3016. http://dx.doi.org/10.3390/molecules29133016.

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The steric interference of proximal dialkyl amino and acyl groups at the peri (1,8) positions of naphthalene affects the intramolecular charge transfer fluorescence. Previous studies indicate that acyl and freely rotating dimethyl amino groups twist toward coplanarity with the naphthalene ring in the excited state. The present study examines the effect of constraining the amino group in a ring. The photophysical properties of 2,2-dimethyl-1-(1-methyl-1,2,3,4-tetrahydrobenzo[h]quinolin-10-yl)propan-1-one (4), ethyl 1-methyl-1,2,3,4-tetrahydrobenzo[h]quinoline-10-carboxylate (5), and 1-methyl-1,

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11

Heravi, Nasir Ahmad, Ahmad Zaher Firoozkohi, and Mostafa Mohammadi. "A Comprehensive Study of the Quinoline Heterocyclic Ring and its Biological as on Antimalarial and Anticancer Agent." Journal of Natural Sciences – Kabul University 6, no. 3 (2025): 227–54. https://doi.org/10.62810/jns.v6i3.342.

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Quinoline is a preferred scaffold that emerges as a significant assembly motif for the creation of novel pharmacological molecules among heterocyclic compounds. Due to the extensive spectrum of biological and pharmacological properties of quinoline and its derivatives, numerous synthetic pathways have been created for their synthesis. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. As a result, these compounds have been produced as intentional structures, and their biological activities have been assesse

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12

Solanki, Shiwangini, Tiwari Archana, and Dubey P.K. "SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL QUINOLINE DERIVATIVES." International Journal of Pharmaceutical Sciences and Medicine 9, no. 6 (2024): 27–35. http://dx.doi.org/10.47760/ijpsm.2024.v09i06.002.

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This study presents the synthesis and antimicrobial evaluation of a series of novel quinoline derivatives. The structures of the synthesized derivatives were confirmed through spectroscopic techniques, including IR spectrometry. The antimicrobial activities of these quinoline derivatives were assessed against a panel of Gram-positive and Gram-negative bacterial strains disc diffusion method. Several compounds exhibited significant antimicrobial activity, with minimum inhibitory concentrations (MICs) comparable to standard antibiotics. The structure-activity relationship (SAR) analysis revealed

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13

Almansour, Abdulrahman I., Natarajan Arumugam, Saradh Prasad, et al. "Investigation of the Optical Properties of a Novel Class of Quinoline Derivatives and Their Random Laser Properties Using ZnO Nanoparticles." Molecules 27, no. 1 (2021): 145. http://dx.doi.org/10.3390/molecules27010145.

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Quinoline Schiff bases display potential applications in optoelectronics and laser fields because of their unique optical properties that arise from extensive delocalization of the electron cloud, and a high order of non-linearity. In this context, a new class of conjugated quinoline-derivative viz. N-(quinolin-3-ylmethylene)anilines were synthesized from 2-hydroxyquinoline-3-carbaldehyde in two good yielding steps. The ability of these imines to accept an electron from a donor is denoted by their electron acceptor number and sites, which is calculated using density functional theory (DFT). Th

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14

S, Priyanka. "Recent advances in Synthesis & Pharmacotherapeutic potential of Benzothiazoles." Der Pharma Chemica 14, no. 1 (2022): 2. https://doi.org/10.5281/zenodo.13353756.

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Isoquinoline is a heterocyclic aromatic organic compound. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in these natural compounds derives from the aromatic amino acid tyrosine.

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15

Khramchikhin, Andrey V., Mariya A. Skryl’nikova, Maxim A. Gureev, et al. "Novel 1,2,4-Triazole- and Tetrazole-Containing 4H-Thiopyrano[2,3-b]quinolines: Synthesis Based on the Thio-Michael/aza-Morita–Baylis–Hillman Tandem Reaction and Investigation of Antiviral Activity." Molecules 28, no. 21 (2023): 7427. http://dx.doi.org/10.3390/molecules28217427.

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A novel method for synthesizing 1,2,4-triazole- and tetrazole-containing 4H-thiopyrano[2,3-b]quinolines using a new combination of the thio-Michael and aza-Morita–Baylis–Hillman reactions was developed. Target compounds were evaluated for their cytotoxicities and antiviral activities against influenza A/Puerto Rico/8/34 virus in MDCK cells. The compounds showed low toxicity and some exhibited moderate antiviral activity. Molecular docking identified the M2 channel and polymerase basic protein 2 as potential targets. We observed that the antiviral activity of thiopyrano[2,3-b]quinolines is nota

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16

Zhao, Yu-Qing, Xiaoting Li, Hong-Yan Guo, Qing-Kun Shen, Zhe-Shan Quan, and Tian Luan. "Application of Quinoline Ring in Structural Modification of Natural Products." Molecules 28, no. 18 (2023): 6478. http://dx.doi.org/10.3390/molecules28186478.

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Natural compounds are rich in pharmacological properties that are a hot topic in pharmaceutical research. The quinoline ring plays important roles in many biological processes in heterocycles. Many pharmacological compounds, including saquinavir and chloroquine, have been marketed as quinoline molecules with good anti-viral and anti-parasitic properties. Therefore, in this review, we summarize the medicinal chemistry of quinoline-modified natural product quinoline derivatives that were developed by several research teams in the past 10 years and find that these compounds have inhibitory effect

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17

Vaghasiya, R. G., H. B. Ghodasara, P. R. Vachharajani, and Viresh H. Shah. "Synthesis, Characterization and Biological Evaluation of 6-Substituted-2-(Substituted-Phenyl)-Quinoline Derivatives Bearing 4-Amino-1,2,4-Triazole-3-Thiol Ring at C-4 Position." International Letters of Chemistry, Physics and Astronomy 27 (February 2014): 30–37. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.27.30.

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Quinoline derivatives represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In this research work, a synthesis, characterization and biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position is described. The synthesis of quinoline derivatives is carried out by the reaction of substituted quinoline-4-carbohydrazides with a mixture of carbon disulphide and potassium hydroxide which further react with hydrazine hydrate to give f

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18

Vaghasiya, R. G., H. B. Ghodasara, P. R. Vachharajani, and Viresh H. Shah. "Synthesis, Characterization and Biological Evaluation of 6-Substituted-2-(Substituted-Phenyl)-Quinoline Derivatives Bearing 4-Amino-1,2,4-Triazole-3-Thiol Ring at C-4 Position." International Letters of Chemistry, Physics and Astronomy 27 (February 6, 2014): 30–37. http://dx.doi.org/10.56431/p-i1j28a.

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Quinoline derivatives represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In this research work, a synthesis, characterization and biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position is described. The synthesis of quinoline derivatives is carried out by the reaction of substituted quinoline-4-carbohydrazides with a mixture of carbon disulphide and potassium hydroxide which further react with hydrazine hydrate to give f

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19

Zavhorodnii, M., N. Derevianko, T. Shkopynska, M. Kornet, and O. Brazhko. "Influence of derivatives of 2-((6-r-quinolin-4-yl)thio)acetic acid on rhizogenesis of Paulownia clones." Regulatory Mechanisms in Biosystems 13, no. 3 (2022): 213–18. http://dx.doi.org/10.15421/022227.

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In recent years, the demand for effective and low-toxic stimulators of rhizogenesis, which are used in microclonal propagation of plants, has been increasing in Ukraine. One of the promising directions in the search for effective compounds is molecular modeling based on known natural and synthetic compounds. The development of new highly effective and low-toxic biologically active compounds is largely based on derivatives of nitrogen-containing heterocycles, and quinoline occupies a significant place among them. Modern methods of chemometric analysis make it possible to find certain regulariti

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20

Murakami-Kubo, Ikuko, Katsumi Doh-ura, Kensuke Ishikawa, et al. "Quinoline Derivatives Are Therapeutic Candidates for Transmissible Spongiform Encephalopathies." Journal of Virology 78, no. 3 (2004): 1281–88. http://dx.doi.org/10.1128/jvi.78.3.1281-1288.2004.

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ABSTRACT We previously reported that quinacrine inhibited the formation of an abnormal prion protein (PrPres), a key molecule in the pathogenesis of transmissible spongiform encephalopathy, or prion disease, in scrapie-infected neuroblastoma cells. To elucidate the structural aspects of its inhibiting action, various chemicals with a quinoline ring were screened in the present study. Assays of the scrapie-infected neuroblastoma cells revealed that chemicals with a side chain containing a quinuclidine ring at the 4 position of a quinoline ring (represented by quinine) inhibited the PrPres forma

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21

Martorana, Annamaria, Gabriele La Monica, and Antonino Lauria. "Quinoline-Based Molecules Targeting c-Met, EGF, and VEGF Receptors and the Proteins Involved in Related Carcinogenic Pathways." Molecules 25, no. 18 (2020): 4279. http://dx.doi.org/10.3390/molecules25184279.

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The quinoline ring system has long been known as a versatile nucleus in the design and synthesis of biologically active compounds. Currently, more than one hundred quinoline compounds have been approved in therapy as antimicrobial, local anaesthetic, antipsychotic, and anticancer drugs. In drug discovery, indeed, over the last few years, an increase in the publication of papers and patents about quinoline derivatives possessing antiproliferative properties has been observed. This trend can be justified by the versatility and accessibility of the quinoline scaffold, from which new derivatives c

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22

Parushev, Stoyan, Yoncho Vlahov, Radoslav Vlahov, Peter Nickel, and Günther Snatzke. "Synthesis of polysubstituted 2,4-dimethylquinolines as potential antimalarial drugs." Collection of Czechoslovak Chemical Communications 56, no. 5 (1991): 1110–15. http://dx.doi.org/10.1135/cccc19911110.

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A synthetic way for obtaining 6-amino-2,4-dimethylquinoline derivatives from 2,5-dichloraniline by successive ring closure, nitration, aromatic substitution at so activated quinoline ring, followed by reduction of the nitro group to amino group and alkylation of the last is described.

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23

R., Lakshmi Gopal* Dr. S. Sreeja S. Ayshu P. s. Devika T. Amina S. Devapriya Kennady Thrishala. "Unlocking The Biological Potential of Quinolines: A Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1085–88. https://doi.org/10.5281/zenodo.15015136.

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Quinoline is an aromatic heterocyclic compound with a double-ring structure of benzene and pyridine, known for its diverse biological activities. It has been extensively studied for its antimalarial, antibacterial, anticonvulsant, anti-inflammatory, and analgesic properties. Quinoline derivatives, such as chloroquine, quinine, and mefloquine, are key treatments for malaria, while quinoline-based antibiotics like fluoroquinolones target bacterial infections. Research into its anticonvulsant, anti-inflammatory, and pain-relieving effects further highlights its therapeutic potential. Due to its v

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24

Panchal, Neil B., and Vipul M. Vaghela. "From Molecules to Medicine: The Remarkable Pharmacological Odyssey of Quinoline and It's Derivatives." Oriental Journal Of Chemistry 39, no. 3 (2023): 546–67. http://dx.doi.org/10.13005/ojc/390303.

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Quinoline, a nitrogen-containing heterocyclic molecule, has emerged as an important scaffold in medicinal chemistry due to its diverse pharmacological effects. The fused quinazoline nucleus in particular has garnered attention for its potent properties, including antibacterial, antiviral, anti-cancer, anti-inflammatory, antioxidant, and anticonvulsant effects. The mechanism of action of these quinoline derivatives is specific to their pharmacological activity. Researchers have studied the chemical and pharmacological properties of quinoline derivatives extensively, with a focus on their antica

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25

Mekheimer, Ramadan Ahmed, Essam Khalaf Ahmed, Hassan Attia El-Fahhama, Laila Hanafy Kamel, and Dietrich Döpp. "Fused Quinoline Heterocycles V. Synthesis of Novel 1,2,3,5,6-Pentaazaaceanthrylene Derivatives." Journal of Chemical Research 2003, no. 7 (2003): 388–89. http://dx.doi.org/10.3184/030823403103174506.

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2,4-Dichloroquinoline-3-carbonitrile (1) with phenylhydrazine in DMF at room temperature gave the 3-amino-4-chloro-1-phenylpyrazolo[4,3- c]quinoline (2). Reaction of 2 with phenyl isothiocyanate afforded the novel fused tetracyclic ring system 1,5-diphenyl-1,5-dihydro-1,2,3,5,6-pentaazaaceanthrylene-4(3 H)-thione (7). Refluxing 2 with excess of a primary amines 8a-d in boiling DMF yielded the corresponding aminopyrazolo[4,3- c]quinolines 9a-d which react with an excess of triethyl orthoformate to furnish 5-substituted 1-phenyl-1,2,3,5,6-pentaaza-aceanthrylenes 11a-d. Reacting 9a with acetic an

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26

Utreja, Divya, Shivali Sharma, Akhil Goyal, Komalpreet Kaur, and Sonia Kaushal. "Synthesis and Biological Activity of Quaternary Quinolinium Salts: A Review." Current Organic Chemistry 23, no. 21 (2020): 2271–94. http://dx.doi.org/10.2174/1385272823666191023122704.

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Heterocyclic chemistry is the only branch of chemistry that has applications in varied areas such as dyes, photosensitizers, coordination compounds, polymeric materials, biological, and many other fields. Quinoline and its derivatives have always engrossed both synthetic chemists and biologists because of their diverse chemical and pharmacological properties as these ring systems can be easily found in various natural products, especially in alkaloids. Among alkaloids, quinoline derivatives i.e. quinolinium salts have attracted much attention nowadays owing to their diverse biological profile

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27

D., PRAKASH, and M. PRASAD S. "Synthesis and Antibacterial Activities of New Quinoline 8-Thioglycollylhydrazones." Journal of Indian Chemical Society Vol. 65, Sep 1988 (1988): 673–75. https://doi.org/10.5281/zenodo.6075948.

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Chemistry Department, Patna University, Patna-800 005 <em>Manuscript received 28 August 1987, revised 19 May 1988, accepted 6 July 1988</em> Synthesis and Antibacterial Activities of New Quinoline 8-Thioglycollylhydrazones.

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28

Khomutetckaia, Aleksandra, Peter Ehlers, Alexander Villinger, and Peter Langer. "Synthesis and Properties of 1H-Pyrrolo[3′,2′:3,4]fluoreno[9,1-gh]quinolines and 7H-Pyrrolo[2′,3′,4′:4,10]anthra[1,9-fg]quinolines." Molecules 30, no. 12 (2025): 2615. https://doi.org/10.3390/molecules30122615.

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We report the synthesis of pyrrolo[3′,2′:3,4]fluoreno[9,1-gh]quinoline and pyrrolo[2′,3′,4′:4,10]anthra[1,9-fg]quinoline derivatives. This novel class of N-doped polycyclic heteroaromatic compounds was synthesized by a site-selective cross-coupling reaction followed by acid-mediated cycloisomerization and Pd-catalyzed CH arylation as the final ring-closing reactions. Preliminary optical and aromatic properties were studied by means of steady-state absorption and fluorescence spectroscopy and DFT calculation. Special emphasis was placed on the impact of ring alternation and position of the N-do

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29

Jatolia, S.N., laxmi Shubh, Lal Kanahiya, N. Bhojak, and O.P Regar. "A REVIEW ON QUINOLINE AND ITS DERIVATIVES." International Journal of Novel Research in Physics Chemistry & Mathematics 9, no. 2 (2022): 6–16. https://doi.org/10.5281/zenodo.6670407.

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<strong>Abstract:</strong> Quinoline is a hygroscopic liquid that is colorless has a pungent odor and Darkens with age. It is soluble in alcohol, ether, benzene, and carbon disulfide and is sparingly soluble in water. Quinoline is a weak tertiary base. It forms salts in acids and exhibits reactions similar to benzene and pyridine, and can engage in both electrophilic and nucleophilic substitution (HSDB), Quinoline, also known as 1-azanaphthalene, 1-benzazine, or benzo[b]pyridine, is a heterocyclic aromatic organic compound. It has the formula C<sub>9</sub>H<sub>7</sub>N.  Quinoline struct

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SERGEEV, A. O., D. V. NOSULYA, A. V. CHERIKOV, D. A. ZABRODA, D. S. KOSYANENKO, and V. M. MOKHOV. "CATALYTIC HYDROGENATION OF PYRIDINE AND QUINOLINE DERIVATIVES." IZVESTIA VOLGOGRAD STATE TECHNICAL UNIVERSITY, no. 5 (300) (May 2025): 7–26. https://doi.org/10.35211/1990-5297-2025-5-300-7-26.

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This article presents a review of catalytic hydrogenation as one of the leading methods for obtaining nitrogen-containing heterocyclic compounds with a reduced ring system, which are valuable products in many industries. Various approaches to the synthesis of these compounds using homo- and heterogeneous catalytic systems and various reducing agents are described, and the main areas of application of reduced N-heterocycles are identified.

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31

Sabo, T., D. Kut, M. Kut, M. Onysko, and V. Lendel. "TELLURO-INDUCED CYCLISATION 2-(BUT-2-ENYLTHIO)QUINOLINECARBALDEHYDE AND QUINOLINE-4-ONE." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 48, no. 2 (2023): 73–78. http://dx.doi.org/10.24144/2414-0260.2022.2.73-78.

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Aryltellurium trichlorides have proven themselves as good cyclizing reagents in electrophilic intramolecular cyclization reactions, mainly of propenyl derivatives of heterocycles. On the other hand, information on the use of butenyl derivatives in reactions with p-alkoxyphenyltellurtrichlorides is limited. In this work, the regioselectivity of the process of electrophilic intramolecular cyclization of but-2-enyl thioethers of quinoline-3carbaldehyde and quinazolin-4-one with p-methoxyphenyltellurium trichloride was investigated. It was established that, as a result of the tellurium-induc

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Chen, Da, Xuan Wang, Runnan Wang, et al. "A Facile One-pot Synthesis of Substituted Quinolines via Cascade Friedlander Reaction from Isoxazoles with Ammonium Formate-Pd/C and Ketones." Letters in Organic Chemistry 17, no. 3 (2020): 211–15. http://dx.doi.org/10.2174/1570178616666190618091617.

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The Friedlander reaction is the most commonly used method to synthesis substituted quinolines, the essential intermediates in the medicine industry. A facile one-pot approach for synthesizing substituted quinolines by the reaction of isoxazoles, ammonium formate-Pd/C, concentrated sulfuric acid, methanol and ketones using Friedlander reaction conditions is reported. Procedures for the synthesis of quinoline derivatives were optimized, and the yield was up to 90.4%. The yield of aromatic ketones bearing electron-withdrawing groups was better than the ones with electron-donating substituents. Th

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Milićević, David, Roman Kimmel, Martin Gazvoda, Damijana Urankar, Stanislav Kafka, and Janez Košmrlj. "Synthesis of Bis(1,2,3-Triazole) Functionalized Quinoline-2,4-Diones." Molecules 23, no. 9 (2018): 2310. http://dx.doi.org/10.3390/molecules23092310.

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Derivatives of 3-(1H-1,2,3-triazol-1-yl)quinoline-2,4(1H,3H)-dione unsubstituted on quinolone nitrogen atom, which are available by the previously described four step synthesis starting from aniline, were exploited as intermediates in obtaining the title compounds. The procedure involves the introduction of propargyl group onto the quinolone nitrogen atom of mentioned intermediates by the reaction of them with propargyl bromide in N,N-dimethylformamide (DMF) in presence of a potassium carbonate and the subsequent formation of a second triazole ring by copper catalyzed cyclisation reaction with

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Chen, Yi-Fong, Bashir Lawal, Li-Jiau Huang, et al. "In Vitro and In Silico Biological Studies of 4-Phenyl-2-Quinolone (4-PQ) Derivatives as Anticancer Agents." Molecules 28, no. 2 (2023): 555. http://dx.doi.org/10.3390/molecules28020555.

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Our previous study found that 2-phenyl-4-quinolone (2-PQ) derivatives are antimitotic agents, and we adopted the drug design concept of scaffold hopping to replace the 2-aromatic ring of 2-PQs with a 4-aromatic ring, representing 4-phenyl-2-quinolones (4-PQs). The 4-PQ compounds, whose structural backbones also mimic analogs of podophyllotoxin (PPT), maybe a new class of anticancer drugs with simplified PPT structures. In addition, 4-PQs are a new generation of anticancer lead compounds as apoptosis stimulators. On the other hand, previous studies showed that 4-arylcoumarin derivatives with 5-

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35

Medvedeva, Svetlana M., Alexey V. Movchan, Ksenia A. Bondarenko, Ksenia Dz Shikhalieva, and Khidmet S. Shikhaliev. "Preparation of individual derivatives in 1,3-oxazino[5,4,3-ij]quinolines and 1,4-oxazino[2,3,4-ij]quinolines series by column chromatography and their mass spectrometric study." Сорбционные и хроматографические процессы 23, no. 4 (2023): 705–15. http://dx.doi.org/10.17308/sorpchrom.2023.23/11577.

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Hundreds of highly effective compounds that have a complex of practically useful properties are known among tricyclic hydroquinolines. Therefore, the production of new compounds of high purity in this series and identification of the features of their behaviour under the influence of electron impact for the determination of their structures is important. Previously, we synthesized 1,3-oxazino[5,4,3-ij]quinoline-1,3-diones and 1,4-oxazino[2,3,4-ij]quinoline-2,3-diones, but the nature of the mass spectral decay for the determination of their structures was not discussed. In this study, using thi

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Karimi, Sasan, Shuai Ma, Keith Ramig, Edyta M. Greer, David J. Szalda, and Gopal Subramaniam. "Oxidative ring-contraction of 3H-1-benzazepines to quinoline derivatives." Tetrahedron Letters 56, no. 49 (2015): 6886–89. http://dx.doi.org/10.1016/j.tetlet.2015.10.094.

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Zvarych, Viktor, Maryna Stasevych, Eduard Rusanov, and Mykhailo Vovk. "A Ring Opening–Annulation Reaction of Anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-trione in the Presence of Pyridines as an Efficient Approach to the Construction of Naphtho[2,3-H]pyrido(quinolino)[2,1-b]quinazoline System." Molecules 27, no. 18 (2022): 5927. http://dx.doi.org/10.3390/molecules27185927.

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The [1,2,3]triazin-4(3H)-one ring is a synthetically important molecular platform for a variety of chemical transformations. Despite this, currently, there has been little research on the reaction of the thermal opening of the [1,2,3]triazin-4(3H)-one nucleus. In this work, we describe the synthetic potential of anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-trione in the reaction of the thermal opening of a cycle following the [4+2]-cycloaddition reaction with a number of pyridine derivatives and quinoline. It is shown that this method is effective for the synthesis of the 6H-naphtho[2,3-H]pyrido(qu

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Gribanova, Yana A., Andrey Yu Potapov, Kristina O. Karelina, et al. "Synthesis of new hybrid molecules based on 7-hydroxy-2,2,4-trimethylhydroquinoline derivatives." Izvestiya of Saratov University. Chemistry. Biology. Ecology 25, no. 1 (2025): 14–22. https://doi.org/10.18500/1816-9775-2025-25-1-14-22.

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Among the fused azaheterocycles, quinolines have long attracted the attention of chemists. First of all, this is due to their wide range of practically useful properties. Quinolines and their derivatives exhibit a wide range of biological activities, including antimalarial, anticancer, antiviral, antifungal and anti-inflammatory activities. These compounds are also used as fluorescent probes, luminescent labels, and in dye production. In the course of this work, a series of pyridocoumarin systems have been obtained, which have been tested as inhibitors of blood clotting factors Xa and XIa. The

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Thakare, M. S., A. K. Yadav, D. Domyati, et al. "Synthesis of Quinoline-based New Organic Chemosensors and its Application in Fluorophoric Detection of Metal-ions in Environmental Samples and Confirmation of Results using Molecular Modelling: A Complete Study." Asian Journal of Chemistry 36, no. 4 (2024): 929–34. http://dx.doi.org/10.14233/ajchem.2024.31322.

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Quinoline-based two new ligands have been synthesized (QL1 and QL2) by reacting 8-quinoline carboxylic acid with derivatives of L-valine under a condensation reaction. The synthesized ligands were characterized by spectroscopic techniques such as 1H NMR, UV, IR, HRMS and CHNS. The 3D structures of both ligands were optimized for the lowest energy and the HOMO-LUMO orbitals were developed. The photoluminescence analysis of both ligands showed the fluorescence emission wavelengths on 492 and 508 nm, respectively for QL1 and QL2. The substituents on the quinoline ring influence the change in fluo

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A., A. FADDA, M. KHALIL A., and M. EL-HABBAL M. "Synthesis of certain Sulphonamides and Aminopyranoquinoline Derivatives from 4-Hydroxyquinoline with Biological Interest." Journal of Indian Chemical Society Vol. 68, Jul 1991 (1991): 393–95. https://doi.org/10.5281/zenodo.5991965.

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Department of Chemistry, Faculty of Science, Mansoura University. Mansoura, Egypt <em>Manuscript received 2 April 1990, revised 21 November 1990, accepted 17 July 1991</em> Various sulpbonamides derivatives (3a-d) have been synthesised by the pyridine ring opening of 4-bydroxyqulnollne monoxime (la-d), and screened for their anti-bacterial activity. Furthermore. the reactivity of 4-hydroxyquinoline (1) towards different activated nitriles has been studied.

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Lu, Yin-Xiang, Bi-Jian Lan, Hui Zhou, Wei Xu, Jing-Mei Wang, and Yong-Ming Huang. "Ring-closure reaction to novel quinoline derivatives and their structural characterization." Chinese Journal of Chemistry 22, no. 8 (2010): 854–58. http://dx.doi.org/10.1002/cjoc.20040220818.

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42

Girgis, Adel S., Marian N. Aziz, ElSayed M. Shalaby, Fahmy M. Asaad, and I. S. Ahmed Farag. "Synthesis and X-ray Studies of Novel Azaphenanthrenes." Journal of Chemical Research 42, no. 2 (2018): 90–95. http://dx.doi.org/10.3184/174751918x15183538282993.

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Two azaphenanthrenes were synthesised by a facile synthetic pathway and characterised by X-ray crystallography. Molecular packing of 4-(2,4-dichlorophenyl)-2-methoxy-5,6-dihydrobenzo[ h]quinoline-3-carbonitrile exhibits C–H…N and C–H…Cl hydrogen bonds in addition to intermolecular C–H…π, Cl…π and π…π (π-ring) stacking interactions. However, molecules of the 2-ethoxy derivative are linked into chains by one hydrogen bond of the C–H…N type and the crystal structure reveals an intermolecular C–H…π (π-ring) interaction. Computational studies by AM1, PM3, and density functional theory (DFT) techniq

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Tempone, André Gustavo, Ana Cláudia Melo Pompeu da Silva, Carlos Alberto Brandt, et al. "Synthesis and Antileishmanial Activities of Novel 3-Substituted Quinolines." Antimicrobial Agents and Chemotherapy 49, no. 3 (2005): 1076–80. http://dx.doi.org/10.1128/aac.49.3.1076-1080.2005.

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ABSTRACT The antileishmanial efficacy of four novel quinoline derivatives was determined in vitro against Leishmania chagasi, using extracellular and intracellular parasite models. When tested against L. chagasi-infected macrophages, compound 3b demonstrated 8.3-fold greater activity than did the standard pentavalent antimony. No significant activity was found for compounds 3a, 4a, and 4b. The antilesihmanial effect of compound 3b was independent of host cell activation, as demonstrated by nitric oxide production. Ultrastructural studies of promastigotes treated with compound 3b showed mainly

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Liu, Sheng, Lian Duan, Ming-Xing Zuo та ін. "Palladium-Catalyzed Cascade Synthesis of Novel Quinolone- Bis(indolyl)methane Hybrids as Promising α-Glucosidase Inhibitors". Synthesis 52, № 11 (2020): 1680–86. http://dx.doi.org/10.1055/s-0039-1690871.

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An unexpected cascade reaction is developed for the construction of functionalized 3-bis(indol-3-yl)methylquinoline-2(1H)-ones. Three C–C bonds and one ring are created in one pot triggered by Pd-catalyzed C-3 alkenylation of indole with 2-acyl-N-acrylaniline derivatives. A series of complex and specific quinoline-2(1H)-ones were produced, most of them showed significant α-glucosidase inhibitory activities.

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Csuvik, Oszkár, Nikoletta Szemerédi, Gabriella Spengler, and István Szatmári. "Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents." International Journal of Molecular Sciences 23, no. 17 (2022): 9688. http://dx.doi.org/10.3390/ijms23179688.

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The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying formaldehyde and piperidine, but a second paraformaldehyde molecule was incorporated into the Mannich product. The reaction also afforded the formation of bisquinoline derivatives. A new 1H-azeto [1,2-a]quinoline derivative was synthesised in two different ways; namely starting from the aminomethylated product or from the ester-hydrolysed 4HQ. Wh

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Yurttaş, Leyla, and Gülşen A. Çiftçi. "New Quinoline Based Sulfonamide Derivatives: Cytotoxic and Apoptotic Activity Evaluation Against Pancreatic Cancer Cells." Anti-Cancer Agents in Medicinal Chemistry 18, no. 8 (2018): 1122–30. http://dx.doi.org/10.2174/1871520618666180307142629.

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Background: Quinoline is a privileged scaffold especially known with antimalarial and antibacterial drugs before, presently followed anticancer efficiency with a new group of protein kinase inhibitors. Objective: In this work, combining quinoline ring, hydrazone and sulphonamide groups, we have synthesized N'-arylidene-2-[4-(quinolin-8-ylsulfonyl)piperazin-1-yl]acetohydrazide derivatives (3a-o) and evaluated their in vitro anticancer activity against cancerous cell lines PANC-1, CAPAN-1, and healthy cell line hTERT-HPNE. Method: Fifteen compounds were synthesized a simple, well-known three-ste

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Mehrabi, Hossein, and Anita Azizian-Broojeni. "One-Pot, Three-Component Condensation Reaction for the Synthesis of Novel Chromeno[3,2-f]Quinoline Derivatives." Journal of Chemical Research 41, no. 12 (2017): 693–95. http://dx.doi.org/10.3184/174751917x15122516000131.

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A one-potsynthesis of novel chromeno[3,2- f]quinoline derivatives has been achieved with good yields through Michael Initiated Ring Closure by employing a three-component condensation of an aromatic aldehyde, 5,5-dimethylcyclohexane-1,3-dione and 6-hydroxyquinoline in the presence of a catalytic amount of Et3N in ethanol under reflux conditions. The salient features of this protocol are a simple reaction procedure, good yields, avoidance of an aqueous work-up and simple purification by recrystallisation.

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Sun, X. H., J. Q. Guan, J. J. Tan, C. Liu, and C. X. Wang. "3D-QSAR studies of quinoline ring derivatives as HIV-1 integrase inhibitors." SAR and QSAR in Environmental Research 23, no. 7-8 (2012): 683–703. http://dx.doi.org/10.1080/1062936x.2012.717541.

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KAMETANI, TETSUJI, YUKIO SUZUKI, HAJIME TAKEDA, et al. "Novel Construction of Quinoline Ring System by Electrocyclic Reaction of Azahexatriene Derivatives." YAKUGAKU ZASSHI 107, no. 2 (1987): 107–10. http://dx.doi.org/10.1248/yakushi1947.107.2_107.

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Johnson, C. D. "ChemInform Abstract: Bicyclic Compounds Containing a Pyridine Ring: Quinoline and Its Derivatives." ChemInform 30, no. 44 (2010): no. http://dx.doi.org/10.1002/chin.199944323.

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