Relevant bibliographies by topics / Randomised clinical trial (RCT)

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Randomised clinical trial (RCT)'

Author: Grafiati
Published: 20 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Randomised clinical trial (RCT)"

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Liu, Xiaoqian, Sarah Robbins, Karen Schuck, and David Hunter. "An Online Clinical Trial Model with Secure Data Management System in the Implementation of Randomised Clinical Trials." Journal of Clinical Rheumatology and Immunology 24, supp01 (2024): 43–44. http://dx.doi.org/10.1142/s266134172474033x.

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Background Nowadays, technological advances enable instant data collection in a secure and confidential manner. Integrating electronic data capture technologies into the online clinical trial design, has been rarely investigated. The aim of this study was to test the feasibility and logistics of the online clinical trial model in osteoarthritis. Methods We used Research Electronic Data Capture (REDCap), a versatile and secure database, as the data management platform. Without face-to-face interactions, the majority of the communications among investigators and between investigators and partici
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Chen, Yu, and Ruiqing Yan. "From registration, protocol to report: are COVID-19-related RCTs in mainland China consistent? A systematic review of clinical trial registry and literature." BMJ Open 12, no. 7 (2022): e058070. http://dx.doi.org/10.1136/bmjopen-2021-058070.

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ObjectiveTo provide a comprehensive review of registered COVID-19-related randomised controlled trials (RCTs) in mainland China and evaluate the transparency of reporting through comparison of registrations, protocols and full reports.DesignSystematic review of trial registrations and publications.Data sourcesInternational Clinical Trials Registry Platform, Chinese Clinical Trial Registry, ClinicalTrials.gov, the ISRCTN registry and EU Clinical Trial Register were accessed on 1 February 2022. Publications were searched in PubMed, Embase, Cochrane Library, Google Scholar, CNKI.net and Wanfangda
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Zaghloul, Hadeel, Odette Chagoury, Sara Elhadad, et al. "Clinical and metabolic characteristics of the Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I) randomised clinical trial cohort." BMJ Open 10, no. 12 (2020): e041386. http://dx.doi.org/10.1136/bmjopen-2020-041386.

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ObjectivesDiabetes Intervention Accentuating Diet and Enhancing Metabolism-I (DIADEM-I) is the first randomised controlled trial (RCT) in the Middle East and North Africa (MENA) region testing the effectiveness of an intensive lifestyle intervention (ILI) for weight loss and diabetes remission. We report on the recruitment process and baseline characteristics of the DIADEM-I cohort based on origin (Middle East vs North Africa), and waist circumference.DesignDIADEM-I is an open-label randomised, controlled, parallel group RCT recruiting young individuals (18–50 years) with early type 2 diabetes
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Planas-Cerezales, Lurdes, Laura Fabbri, and Laurence Pearmain. "Add-on therapy for pulmonary fibrosis, a forthcoming era with implications for practice: the BI 101550 and RELIEF trials." Breathe 19, no. 3 (2023): 230090. http://dx.doi.org/10.1183/20734735.0090-2023.

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The therapeutic landscape for idiopathic pulmonary fibrosis (IPF) and progressive fibrosing interstitial lung disease (PFILD) is increasingly complex, with add-on antifibrotic options now in clinical trials, or available for patients progressing on first-line therapy in both conditions. Here, we review two recent trials of potential add-on therapeutic options, the BI 101550 and RELIEF trials. BI 101550 was a phase 2 randomised control trial (RCT) of a novel phosphodiesterase-4 inhibitor in patients with IPF, with a primary end-point of change in forced vital capacity (ΔFVC) (in mL) at 12 weeks
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Jenkins, Valerie A., and Lesley J. Fallowfield. "For the Benefit of Others: Reasons Why Women with Breast Cancer Participate in RCTs." Breast Care 10, no. 2 (2015): 88–93. http://dx.doi.org/10.1159/000376563.

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Background: Appreciation of the barriers and drivers affecting enrolment in randomised clinical trials (RCTs) is important for future trial design, communication and information provision. Methods: As part of an intervention to facilitate UK multidisciplinary team communication about RCTs, women with breast cancer who discussed trials with doctors or research nurses completed questionnaires examining i) clarity of trial information and ii) reasons for their trial decision. Results: 152 women completed the questionnaires; 113/152 (74%) consented to RCT enrolment. Patients' satisfaction with com
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Chen, Stephanie C., Cheryl McCullumsmith, and Scott Y. H. Kim. "Disclosing the potential impact of placebo controls in antidepressant trials." BJPsych Open 1, no. 1 (2015): 1–5. http://dx.doi.org/10.1192/bjpo.bp.115.000109.

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BackgroundAlthough placebo-control clinical trials that withhold effective treatments can be permissible, how best to inform participants of the placebo design has received little attention.AimsTo determine the effect of disclosing quantitative outcome estimates of individual treatment v. entering placebo-control randomised control trial (RCT) on willingness to enrol in such an RCT.MethodWe randomised 278 adult patients at a depression clinic to receive standard disclosure (n = 129) or enhanced (n = 149) quantitative outcome estimates (based on decision analysis) of individual treatment v. RCT
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Hamilton, E. P., G. H. Lyman, S. Kim, and J. Peppercorn. "Availability of experimental therapy outside of randomized clinical trials in oncology." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6539. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6539.

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6539 Background: Investigational cancer therapies may be available outside of trials, or “off protocol” (OPRx), with implications for patient safety, trial accrual, and access to care. Previous studies suggest OPRx is prevalent in oncology, but there is little consensus on when it should or should not be considered. We evaluated the scope and impact of OPRx through assessment of availability of the experimental arms of recent randomized trials (RCT), and evaluation of study outcomes and accrual. Methods: We conducted a Medline search to identify all English language phase III RCT of medical in
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Keogan, Sheila, Shasha Li, and Luke Clancy. "Allen Carr’s Easyway to Stop Smoking - A randomised clinical trial." Tobacco Control 28, no. 4 (2018): 414–19. http://dx.doi.org/10.1136/tobaccocontrol-2018-054243.

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Objective To determine if Allen Carr’s Easyway to Stop Smoking (AC) was superior to Quit.ie in a randomised clinical trial (RCT). Setting Single centre, open RCT, general population based. Participants 300 adult smokers, 18 years plus, minimum 5 cigarettes daily, and English speaking. AC, 151 (females 44.4%) and Quit.ie, 149 (females 45.6%), mean age 44 years. outcomes for all 300 were analysed (intention-to-treat). Recruited through advertisement from July 2015 to February 2016. Intervention Randomly assigned to AC (n=151) and Quit.ie (n=149), matched for age, sex and education. Block randomi
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Alli, Babatunde Y., Sreenath Madathil, Simon D. Tran, and Belinda Nicolau. "Protocol: carrageenan for the prevention of oral HPV infection – a feasibility randomised clinical trial." BMJ Open 13, no. 7 (2023): e074498. http://dx.doi.org/10.1136/bmjopen-2023-074498.

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IntroductionHead and neck cancers (HNCs) are a significant health burden worldwide. Oral human papillomavirus (HPV) infection is a major risk factor for HNCs. Unfortunately, currently available prophylactic vaccines have limited coverage and potential for HPV type replacement. Carrageenan, a natural product extracted from marine red algae, has demonstrated potency as an HPV inhibitor and could offer a potential alternative to prevent HPV-related diseases, including oral HPV infection. However, there is a lack of clinical studies on the effect of carrageenan on oral HPV infections. As a first s
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Logroscino, Giancarlo. "Randomized clinical trial (RCT): An overview." eNeurologicalSci 38 (March 2025): 100547. https://doi.org/10.1016/j.ensci.2025.100547.

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Dissertations / Theses on the topic "Randomised clinical trial (RCT)"

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Anjara, Sabrina Gabrielle. "A study of two models of primary mental health care provisions in Yogyakarta, Indonesia." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289729.

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Background The World Health Organization (WHO) defines health as a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. Despite its importance, mental health provisions are often limited. In 2015, Indonesia had only 773 psychiatrists for 250 million residents. This shortage of specialist mental health professionals is shared by most Low- and Middle-Income Countries (LMICs) and is reflected in the Treatment Gaps in this region indicating the very small proportion of people who receive adequate mental health care for their needs. While the
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Daures, Maguy. "Évaluation d'une stratégie de prise en charge simplifiée de la malnutrition aiguë chez des enfants de 6 à 59 mois en Afrique Sub-saharienne dans le cadre d’un programme de recherche co-construit entre humanitaires et chercheurs." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0067.

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La malnutrition aiguë (MA) est un défi mondial, touchant 45 millions d'enfants de moins de 5 ans et est une cause sous-jacente de 800 000 décès annuels. Les protocoles de prise en charge, bien que efficaces, souffrent d'un financement insuffisant et d'une couverture limitée. Ces protocoles divisés en deux programmes pour les enfants malnutris aigus sévères et modérés sont complexes et utilisent des traitements différents avec des dosages non optimaux. Pour répondre à ces défis, l’organisation non gouvernementale (ONG) « The Alliance for International medical action » (ALIMA) a développé le pro
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Deak, Stefan, and Glenn Kristoffersson. "Rädslan för det som finns och inte finns : En randomiserad kontrollerad jämförelse av utfall mellan sedvanlig ensessionsbehandling och behandling med virtuella stimuli mot spindelfobi." Thesis, Stockholms universitet, Psykologiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-130712.

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Specifik fobi är en vanlig psykiatrisk åkomma som kan leda till stora individuella begränsningar. Symtomen kan framgångsrikt behandlas med kognitiv beteendeterapi där 85–90 % blir kliniskt signifikant förbättrade. Forskning påvisar lovande behandlingsutfall för virtuell exponeringsbehandling (VRET) mot spindelfobi. Tekniken är intressant då den kringgår de problem med anskaffning och förvaring av fobiska stimuli som sedvanlig behandling medför och dessutom kan innebära ökad tillgänglighet och flexibilitet vid behandling. Syftet med föreliggande studie är att jämföra behandlingseffekten av ense
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Nohlert, Eva. "Smoking Cessation : Treatment Intensity and Outcome in Randomized Clinical Trials." Doctoral thesis, Uppsala universitet, Centrum för klinisk forskning, Västerås, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-208972.

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The primary aim was to compare the effectiveness of smoking cessation interventions of different intensities in a clinical dental and a telephone setting in Sweden. Methods: A total of 300 smokers were randomized to High or Low Intensity Treatment (HIT or LIT) at the Public Dental Service, County Council of Västmanland. Effectiveness (abstinence rate) was measured after 1yr (paper I) and 5-8yrs (paper III). A cost-effectiveness analysis was conducted, based on intervention costs, number of abstinent participants after 1yr, and a Markov modelling of future costs and health (in QALYs) consequenc
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Walid, Rania. "Impact Evaluation in Post-conflict Environments : A Critical Appraisal of Randomised Controlled Trial (RCT)." Thesis, Linnéuniversitetet, Institutionen för samhällsstudier (SS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-104816.

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Impact evaluations in development interventions has been growing in recent years. The increasing demand for evidence-based outcomes has led to a debate of what methodology is best to evaluate the impact of development interventions. Accordingly, Randomised Controlled Trial (RCT) has been labeled as a gold standard for impact evaluations. The RCT method functions in a unique way, as it removes the selection bias and ensure high validity of a study. The aim of this research study is to critically assess the RCT as an alternative approach for impact assessment in relation to post-conflict countri
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Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215848.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u
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Spieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Dove Medical Press, 2016. https://tud.qucosa.de/id/qucosa%3A29007.

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Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials u
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Featherstone, Katie. "Patient perspectives of participation in a randomised controlled trial." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/06229618-6e8d-4764-8c7a-1f0c0d0af307.

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Schuh, Sr Matthew Anderson. "The Epistemic Necessity and Ethical Permissibility of Randomized Clinical Trials: A Minimalist Defense." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/167.

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I argue for two main theses that are at odds with the positions of many clinical researchers and philosophers who write on the ethics of clinical research. The first is that certain types of clinical trials, namely, randomized clinical trials with double or triple blinding and a placebo group are generally necessary to establish that a medical intervention is effective in treating a certain type of disease or disorder. The second main thesis is that such trials are generally not ethically impermissible. My minimalist defense of clinical trials differs from most defenses of clinical trials fou
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Slater, Karen. "Improving Care of Peripheral Intravenous Needleless Connectors." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/412414.

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Background: Most hospitalised patients have a peripheral intravenous catheter (PIVC) at some point during hospitalisation. Although the rate of bloodstream infection (BSI) for PIVCs is low, the sheer number of devices inserted makes them a device of interest, since cumulatively many infections occur worldwide each year. Access to intravenous (IV) lines for the administration of medication and fluids in most of the developed world is through the needleless connector (NC) component of a PIVC. NCs were introduced several decades ago to reduce the risk of needlestick injuries amongst healthcare wo
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Books on the topic "Randomised clinical trial (RCT)"

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G, Zermansky A., National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. Clinical medication review by a pharmacist of patients on repeat prescriptions in general practice: A randomised controlled trial. Core Research on behalf of the NCCHTA, 2002.

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Downe, Susan Mary. Reducing the risk of adverse outcome for nulliparous women using epidural analgesia in labour: A randomised clinical trial and longitudinal follow-up survey.... University of Derby], 1999.

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Strand, Vibeke, Jeremy Sokolove, and Alvina D. Chu. Design of clinical trials in rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0030.

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Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, 'first-in-human' to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the pas
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Strand, Vibeke, Jeremy Sokolove, and Alvina D. Chu. Design of clinical trials in rheumatology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0030_update_001.

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Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, ’first-in-human’ to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the pas
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Strand, Vibeke, Jeremy Sokolove, and Alvina D. Chu. Design of clinical trials in rheumatology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199642489.003.0030_update_002.

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Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, ’first-in-human’ to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the pas
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Farrar, John T. Understanding clinical trials in palliative care research. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0193.

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Advances in basic science, translational, and clinical research have led to rapid improvements in our understanding of many disease processes. The randomized clinical trial (RCT) has played an important role in validating the benefits and harms of therapies thought to be potentially useful based on scientific theory or clinical observation, and has become the ‘gold standard’ for the demonstration of efficacy. As in all clinical study designs, the RCT has strengths and weaknesses that must be understood to appropriately interpret the study results. While randomization of the intended study popu
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Fishman, Daniel B., Stanley B. Messer, David J. A. Edwards, and Frank M. Dattilio, eds. Case Studies Within Psychotherapy Trials. Oxford University Press, 2017. http://dx.doi.org/10.1093/med:psych/9780199344635.001.0001.

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The Cases Within Trials (CWT) model combines the randomized clinical trial (RCT) research design, based on quantitative group research, with richly and qualitatively detailed systematic case studies involving contrasting outcomes drawn from the experimental condition of the RCT. Chapter 1 of the book provides the broad historical and methodological context out of which the CWT method developed, including the recent dramatic growth of mixed-methods approaches in psychotherapy research generally, with an associated increase in their credibility and rigor. Chapter 2 presents the details of the CW
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Welsh, Brandon C., Steven N. Zane, and Scott H. Podolsky. Between Medicine and Criminology. Oxford University Press, 2025. https://doi.org/10.1093/oso/9780197675946.001.0001.

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Abstract As the first randomized controlled trial (RCT) in criminology and one of the earliest RCTs of a social program, the Cambridge-Somerville Youth Study (CSYS) represents a landmark study in the history of criminology. The twin goals of the CSYS were to evaluate the effects of a delinquency prevention intervention and to investigate the development of delinquency and later criminal offending over the life-course. To achieve these objectives, a renowned physician and professor of clinical medicine and social ethics at Harvard University, Dr. Richard C. Cabot, developed a novel and highly r
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Elwood, Mark. Critical appraisal of a randomized clinical trial. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682898.003.0012.

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This chapter presents a randomised trial carried out in primary care in the UK, assessing the use of an antibiotic, chloramphenicol, for acute eye infections (conjunctivitis) in children. This study shows the challenges of conducting a high quality randomised trial in primary care, including issues of the appropriate assessment of outcome. The critical assessment follows the scheme set out in chapter 10: describing the study, assessing the non-causal explanations of observation bias, confounding, and chance variation; assessing time relationships, strength, dose-response, consistency and speci
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Elshazali, Osama Hafiz. Double-Blind, Randomised Clinical Trial of Two Different Dosing Regimens of Praziquantel. BAYSHOP (Generis Publishing), 2022.

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Book chapters on the topic "Randomised clinical trial (RCT)"

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Bulpitt, Christopher J. "Different Trial Designs." In Randomised Controlled Clinical Trials. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_5.

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Bulpitt, Christopher J. "Information to be Collected During a Trial." In Randomised Controlled Clinical Trials. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_10.

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Bulpitt, Christopher J. "The Objectives of a Randomised Controlled Trial." In Randomised Controlled Clinical Trials. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_4.

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Bulpitt, Christopher J. "The Conduct of the Trial — Good Clinical Practice." In Randomised Controlled Clinical Trials. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_11.

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Bulpitt, Christopher J. "How Many Subjects are Required For a Trial?" In Randomised Controlled Clinical Trials. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_6.

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Nagappa, A. N., and Shvetank Bhatt. "RCT, Systematic Reviews, and Evidence-Based Medicine: Randomized Clinical Trials (RCT)." In Perspectives in Pharmacy Practice. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9213-0_20.

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Tchero, Huidi. "Management of Scars in Skin of Color." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_43.

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AbstractKeloids and hypertrophic scars are abnormal scars, produced by an odd wound-healing response to trauma with a higher incidence in pigmented skin patients. They could be painful or itchy, producing functional and/or cosmetic disability. This chapter focuses on defining scars especially in pigmented skin and the different methods for treating keloids that have been investigated in the literature. Up to the present time, the ideal treatment method has not been defined, although numerous modalities have been designated. We will represent the variances among different scar types and their m
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de Bie, R. A., A. P. Verhagen, T. F. Lenssen, and H. C. W. de Vet. "Efficacy of Low Level Laser Therapy in Ankle Sprains; a Randomised Clinical Trial." In Hefte zur Zeitschrift „Der Unfallchirurg“. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60913-8_260.

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Turner, J. Harvey. "Evaluation of Real-World Efficiency of 177Lu-PSMA Radioligand Therapy of Metastatic Prostate Cancer." In Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-33533-4_33.

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AbstractThroughout the world, hundreds of patients with advanced metastatic prostate cancer are currently being treated with 177Lu-PSMA radioligands on compassionate usage protocols in accord with published guidelines of the European Association of Nuclear Medicine (EANM). However, 7 years after the introduction of 68Ga/177Lu-PSMA theranostic management of metastatic castration-resistant prostate cancer (mCRPC), it remained unapproved by any national regulatory authority, and has yet to achieve oncologist/urologist acceptance into mainstream clinical practice. The reasons for the nonacceptance
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Sammour, Tarik. "Survival after Laparoscopic Surgery versus Open Surgery for Colon Cancer: Long-Term Outcome of a Randomised Clinical Trial (COLOR Trial)." In 50 Landmark Papers every Colorectal Surgeon Should Know. CRC Press, 2024. http://dx.doi.org/10.1201/9780429285714-42.

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Conference papers on the topic "Randomised clinical trial (RCT)"

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Conejero Hall, Laura, Luis Puente Maestu, Myriam Calle Rubio, et al. "RCT Abstract - Randomized, double-blind, placebo-controlled, phase III clinical trial with MV130, a sublingual bacterial immunotherapy to prevent COPD exacerbations." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.rct207.

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Novitasari, Elisa, RB Soemanto, and Hanung Prasetya. "Acupuncture Therapy in Reducing Pain in Patients with Low Back Pain: Meta Analysis." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.43.

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ABSTRACT Background: With growing evidence of high prevalence in developing countries, LBP is no longer recognized as a disorder confined to high-income nations but is a major health problem globally. The functional limitations and consequent disability create a heavy economic burden on individuals and society. This study aimed to acupuncture therapy in reducing pain in patients with low back pain. Subjects and Method: A meta-analysis and systematic review was conducted by search published articles from PubMed, Google Schoolar, Mendeley, Hindawi, and Clinical key databases. Keywords used “acup
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Lera Dos Santos, M. E., I. M. Proença, S. E. Matuguma, et al. "SELF-EXPANDABLE METAL STENT (SEMS) VERSUS LUMEN-APPOSING METAL STENT (LAMS) FOR EUS-DRAINAGE OF PANCREATIC FLUID COLLECTIONS: RANDOMIZED CLINICAL TRIAL (RCT)." In ESGE Days 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1745234.

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Fatati, Muhibbah, Setyo Sri Rahardjo, and Hanung Prasetya. "Lateral Wedge Insole Uptake in Reducing Pain in Patients with Knee Osteoarthritis: A Meta-Analysis Study." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.45.

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ABSTRACT Background: The increase in rates of knee replacement for osteoarthritis has made the identification of effective nonsurgical treatments a high priority. One type of treatment for medial knee osteoarthritis involves reducing medial loading to ease the physical stress applied to that compartment of the joint. The wedge is placed under the sole of the foot and angulated so that it is thicker over the lateral than the medial edge, transferring loading during weight bearing from the medial to the lateral knee compartment. This study aimed to investigate the effect of lateral wedge insole
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Aggarwal, N. R., J. Nordwall, T. Der, et al. "Association and Additive Risk of Respiratory and Viral Response Baseline Variables With Mortality in Therapeutics for Inpatients With COVID-19 (TICO) Platform Randomized Clinical Trial (RCT) Participants." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6556.

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Goodwin, PJ, M. Ennis, DW Cescon, et al. "Abstract P1-16-03: Phase II randomized clinical trial (RCT) of metformin (MET) vs placebo (PLAC) in combination with chemotherapy (CXT) in refractory locally advanced (LABC) or metastatic breast cancer (MBC)." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p1-16-03.

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Saputri, Nurul Aini Suria, Tri Nugraha Susilawati, and Vitri Widyaningsih. "Relative Efficacy of Probiotics Compared with Standard Therapy for Diarrhea Treatment in Children Under Five Years of Age: A Meta-Analysis Evidence from Developing Countries." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.03.95.

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ABSTRACT Background: Probiotics have been widely studied in a variety of gastrointestinal diseases. There is high-quality evidence that probiotics are effective for acute infectious diarrhea. This study aimed to examine the relative efficacy of probiotics compared with standard therapy for diarrhea treatment in children under five using meta-analysis. Subjects and Method: A meta-analysis was carried out using systematic PRISMA guidelines. The review process begins with searching for articles published between 2009 and 2019 from PubMed, Clinical Key, ScienceDirect, and Scopus databases. This st
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El Hajj, Maguy, Ahmed Awaisu, Nadir Kheir, et al. "Assessment of an Intensive Education Program on the Treatment of Tobacco-Use Disorder for Pharmacists using OSCE (Objective Structured Clinical Examination)." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0113.

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Tobacco use is one of the main causes of morbidity and mortality in Qatar. The aim of this randomized controlled trial (RCT) is to design, implement, and evaluate an intensive education program on tobacco-use treatment for pharmacists in Qatar. The study objectives are to assess the effectiveness of the program on pharmacists’ skills toward tobacco cessation. Methods: A random sample of community pharmacists in Qatar was selected for participation. Consenting participants were randomly allocated to intervention or control groups. Participants in the intervention group received an intensive edu
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Mcdonald, Vanessa, Vanessa Clark, Peter Wark, Katherine Baines, and Peter Gibson. "Multidimensional assessment and targeted therapy of severe asthma: a randomised controlled trial (RCT)." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.oa1482.

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Dhooria, Sahajal, Inderpaul Singh Sehgal, Ritesh Agarwal, Kuruswamy Thurai Prasad, and Ashutosh Nath Aggarwal. "RCT Abstract - High-dose (40 mg) versus low-dose (20 mg) prednisolone for treating sarcoidosis: a randomised trial (SARCORT trial)." In ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.rct797.

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Reports on the topic "Randomised clinical trial (RCT)"

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Villa, Michele, Massimo Le Pera, and Michela Bottega. Quality of Abstracts in Randomized Controlled Trials Published in Leading Critical Care Nursing Journals. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0039.

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Review question / Objective: This review aims to evaluate the methodological quality of RCT-abstracts in leading critical care nursing journals. A methodological quality review with the Consolidated Standards of Reporting Trials (CONSORT) criteria will be performed in RCT-abstracts published between 2011-2021 in the first Scopus-ranking (2021) nursing journals. Eligibility criteria: Abstracts of scientific articles will be included if they fulfil the following inclusion criteria: 1) they report the results of parallel and/or cross-over group RCTs, 2) they are written in English, 3) they refer
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Moxham-Hall, Vivienne, Anton du Toit, Sallie Newell, Stuart Brentnall, Deshanie Rawlings, and Eileen Goldberg. Proton beam therapy: a rapid review of the evidence since 2020. The Sax Institute, 2023. http://dx.doi.org/10.57022/nbys4168.

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This report for Cancer Australia is a rapid review of the evidence since 2020 on proton beam therapy (PBT) for paediatric cancers, central nervous system (CNS) tumours, head and neck cancer and prostate cancer. The report aims to provide a rapid summary of the current knowledge about PBT’s effectiveness, safety, and potential advantages over conventional radiation therapy. We identified the following papers for full review: 24 peer reviewed papers, including 4 meta-analyses, 16 systematic reviews, 3 narrative reviews, and 1 randomised controlled trial (RCT); and 2 publicly available health tec
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Shi, Min, Yao Yao, Haifeng Ding, et al. The Pharyngeal Packs for Dental and Otolaryngological Surgery: A Meta-analysis of High-quality RCTs. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0002.

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Review question / Objective: To quantitatively evaluate the role of pharyngeal packing in dental and otolaryngological surgeries by meta-analysis Eligibility criteria: Trials were included if they met the following criteria: (1) high-quality randomized controlled trial; (2) application of pharyngeal pack was the only intervention; (3) investigations of dental and otolaryngological surgeries; (4) full English text could be identified; and (5) at least one available parametric indicator was addressed.The exclusion criteria were as follows: (1) low-quality RCT or non-RCT; (2) pharyngeal pack was
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Li, Yaodong, Zuoqiong Zhou, Yiping WANG, et al. Comparison of oral sodium phosphate tablets and polyethylene glycol lavage solution for colonoscopy preparation: A systematic review and meta-analysis of randomized clinical trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.5.0013.

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Review question / Objective: To systematically compare the bowel cleaning ability, patient tolerance and safety of oral sodium phosphate tablets (NaPTab) and oral polyethylene glycol electrolyte lavage solution (PEGL) to inform clinical decision making. Review question include: 1) patient populations with an indication for colonoscopy, including outpatients or inpatients requiring diagnosis or treatment, 2) randomized controlled trial (RCT) study designs, 3) a sodium phosphate tablet intervention group, 4) a control group receiving PEGL administered orally or by nasogastric tube, and 5) outcom
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Xing, Lei, Hongmin Guo, and Zhiqian Wang. Efficacy and safety of Suzi Jiangqi Decoction in patients with acute exacerbation of chronic obstructive pulmonary disease A protocol for systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.8.0035.

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Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic respiratory symptoms. The respiratory symptoms of patients with acute exacerbation of COPD (AECOPD) worsen rapidly. At present, traditional western medicine treatment can not effectively alleviate the symptoms and attack frequency of patients. Suzi Jiangqi decoction(SZJQ) has a good clinical effect in the treatment of AECOPD. Due to the lack of evidence-based medicine, it can not provide an effective systematic evaluation for the treatment of AECOPD with Suzi Jiangqi decoction. Therefore, it is necessary to pr
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Han, Nana, Yang Fang, Guozhen Zhao, and Bo Ji. The comparative efficacy and safety of acupuncture for mild and moderate Alzheimer's disease: A systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.11.0014.

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Review question / Objective: According to the current randomized clinical trials (RCT) of acupuncture therapy for Alzheimer's disease (AD), to evaluate their methodology, the quality of evidence and the report are evaluated and summarize evidence of important outcomes of randomized clinical trials. We aim to provide accurate clinical decision-making for acupuncture treatment of Alzheimer's disease. Condition being studied: According to the current randomized clinical trials (RCT) of acupuncture therapy for Alzheimer's disease (AD), to evaluate their methodology, the quality of evidence and the
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Tang, Li-li, Yue-dong Liu, Hong-wu Tao, Wen-zhe Feng, Yu-ping Shu, and Fan-yan Meng. The efficacy and safety of ulcerative colitis treatment based on the theory of the " lung–gut axis ": a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.3.0014.

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Review question / Objective: The purpose of this study was to investigate the difference between the curative effect of traditional Chinese medicine or integrated traditional Chinese and Western medicine on ulcerative colitis under the guidance of lung-intestine axis theory and that of Western medicine alone. The selected research method was to search relevant randomized controlled trial in Chinese and English medical databases. The Cochrane bias risk assessment tool was used to analyze the quality of RCT studies, and RevMan 5.3 was used for efficacy evaluation and meta-analysis. Condition bei
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Yan, Miao, Shuang Xia, and Yichang Zhao. Risk of sepsis in cancer patients treated with immune checkpoint inhibitors: a safety meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.4.0174.

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Review question / Objective: The aim of this meta-analysis is to estimate the risk of sepsis in cancer patients treated with immune checkpoint inhibitors in randomized controlled trials (RCTs). Condition being studied: Sepsis-related toxicities in cancer patients received immune checkpoint inhibitors. Information sources: Electronic databases:Medline; Embase; Central; Trial registers: ClinicalTrails.gov. EU Clinical Trials Register. International Clinical Trials Registry Platform. Regarding RCTs for which we had neither available adverse events on ClinicalTrials.gov nor available adverse event
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Wang, Jiajie, Wei Huang, Yanji Zhang, Zhengrong Zhao, and Zhongyu Zhou. Acupuncture and related interventions for the treatment of obesity: protocol for a scoping review of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.3.0099.

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Review question / Objective: The purpose of this study is to summarize the characteristics of RCT in the treatment of obesity by acupuncture and other related intervention measures, so as to enhance evidence-based clinical practice about acupuncture for obesity. Condition being studied: Obesity is a chronic metabolic disease that is defined as a body's excessive accumulation or abnormal distribution of total or local fat content. Their complications such as Type II diabetes mellitus, hyperlipidemia, and cardiovascular diseases are strongly related to higher risks of mortality. In recent years,
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Gupta, Tejpal, Riddhijyoti Talukdar, Sadhana Kannan, Archya Dasgupta, Abhishek Chatterjee, and Vijay Patil. Meta-Analysis of Standard Temozolomide versus Extended Adjuvant Temozolomide following concurrent Radiochemotherapy in newly-diagnosed Glioblastoma (MASTER-G). INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.12.0114.

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Review question / Objective: To assess the safety and efficacy of extended adjuvant temozolomide compared to standard adjuvant temozolomide after concurrent radiochemotherapy in patients with newly-diagnosed glioblastoma. Condition being studied: Newly-diagnosed glioblastoma. Eligibility criteria: Prospective clinical trials randomly assigning patients to extended (>6-cycles) adjuvant TMZ (experimental arm) or standard (6-cycles) adjuvant TMZ will be included. Randomization in an individual study may have been done upfront before concurrent phase (RT/TMZ), after completion of concurrent RT/
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