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Journal articles on the topic 'Rapid onset of action'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Machado-Vieira, Rodrigo, Giacomo Salvadore, David A. Luckenbaugh, Husseini K. Manji, and Carlos A. Zarate. "Rapid Onset of Antidepressant Action." Journal of Clinical Psychiatry 69, no. 6 (2008): 946–58. http://dx.doi.org/10.4088/jcp.v69n0610.

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2

Montgomery, S. A. "Rapid onset of action of venlafaxine." International Clinical Psychopharmacology 10 (March 1995): 21–28. http://dx.doi.org/10.1097/00004850-199503002-00005.

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3

Taylor, Matthew J. "Rapid onset of true antidepressant action." Current Psychiatry Reports 9, no. 6 (2007): 475–79. http://dx.doi.org/10.1007/s11920-007-0064-0.

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4

Montgomery, SA. "Clinical measures of rapid onset of action." European Psychiatry 12, S4 (1997): 295s—300s. http://dx.doi.org/10.1016/s0924-9338(97)83308-1.

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SummaryThe benefits of an antidepressant with an early or rapid onset of action include a more rapid resolution of the debilitating symptoms of depression, a potential reduction in the risk of suicide and cost savings associated with a reduction in hospitalization. While these benefits are valuable, this promise has yet to be fulfilled by any antidepressant. Venlafaxine is a unique serotonin-noradrenaline reuptake inhibitor (SNRI) which produces rapid and prolonged desensitization of β-adrenergic receptors in preclinical studies after both acute and chronic administration of venlafaxine. Resul

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5

Artigas, F. "S.11.03 Potential rapid onset: Mechanisms of action." European Neuropsychopharmacology 7 (September 1997): S100—S101. http://dx.doi.org/10.1016/s0924-977x(97)88394-0.

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6

Montgomery, S. A. "SAT-3-3 Rapid onset of action: Clinical relevance to antidepressant action." European Neuropsychopharmacology 5, no. 3 (1995): 252–53. http://dx.doi.org/10.1016/0924-977x(95)90317-7.

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7

Henahan, Sean. "New treatments with rapid onset of action for affective disorders." Inpharma Weekly &NA;, no. 1013 (1995): 15. http://dx.doi.org/10.2165/00128413-199510130-00037.

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8

French, Jacqueline, and Celestina Arrigo. "Rapid Onset of Action of Levetiracetam in Refractory Epilepsy Patients." Epilepsia 46, no. 2 (2005): 324–26. http://dx.doi.org/10.1111/j.0013-9580.2005.31504.x.

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9

Wegener, Thomas, Hans Hedenström, and Bo Melander. "Rapid Onset of Action of Inhaled Formoterol in Asthmatic Patients." Chest 102, no. 2 (1992): 535–38. http://dx.doi.org/10.1378/chest.102.2.535.

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10

Blier, P., and B. Bergeron. "Combination treatments with rapid onset of action in major depression." European Neuropsychopharmacology 6 (September 1996): S4–23. http://dx.doi.org/10.1016/0924-977x(96)82883-5.

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11

Yasuhiro, Matsumura. "Recent Topics in Steroid and Asthma: Beyond the 'Classic' Concept of Action." Global Journal of Allergy 1, no. 2 (2015): 024–28. https://doi.org/10.17352/2455-8141.000005.

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Glucocorticoid (GC)s exert anti-inflammatory effects via binding to the glucocorticoid receptor (GR) (NR3C1), targeted gene expression, and protein synthesis, which need hours before the onset of the action (transactivation). GCs also suppress inflammation by direct or indirect interaction with transcription factors, such as activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) (transrepression). Recently, the non-genomic actions of GCs were discovered on recognition of its rapid onset of action within seconds to minutes.

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12

Li, Xiaoshen, Cynthia Czajkowski, and Robert A. Pearce. "Rapid and Direct Modulation of GABAAReceptors by Halothane." Anesthesiology 92, no. 5 (2000): 1366–75. http://dx.doi.org/10.1097/00000542-200005000-00027.

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Background Hypotheses regarding the nature of channel modulation by volatile anesthetics have focused primarily on "membrane actions" of anesthetics and more recently on direct actions of volatile agents on receptor proteins themselves. With the recognition that many channels are subject to modulation by intracellular enzymes, such as protein kinases and phosphatases, and recent demonstrations that the activity of these modulators themselves may be altered by anesthetic agents, a third possibility has been suggested:-anesthetic actions on channels may be indirect, produced, for example, via di

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13

Makky, Amna M. A., Iman S. Ahmed, Mohamed A. El-Nabaraw, and Rehab A. Abd El-Mon. "Development of a New Carvedilol Tablet with Rapid Onset of Action." American Journal of Drug Discovery and Development 2, no. 2 (2012): 55–71. http://dx.doi.org/10.3923/ajdd.2012.55.71.

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14

Abou-Khalil, Bassel W. "Dietary Therapy for Epilepsy: The Advantage of Rapid Onset of Action." Epilepsy Currents 9, no. 2 (2009): 40–41. http://dx.doi.org/10.1111/j.1535-7511.2008.01286.x.

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15

Papp, M., and P. Willner. "Rapid onset of antidepressant action in an animal model of depression." European Neuropsychopharmacology 6 (September 1996): S4–22. http://dx.doi.org/10.1016/0924-977x(96)82882-3.

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16

Steiner, S., M. Hompesch, R. Pohl, et al. "A novel insulin formulation with a more rapid onset of action." Diabetologia 51, no. 9 (2008): 1602–6. http://dx.doi.org/10.1007/s00125-008-1095-8.

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17

Pyo, Sung Min, Daniel Jacobi, Nina Jaensch, Marko Lo Piparo, and Helen Hertenstein. "A Novel Sublingually Applied Melatonin Nanoemulsion Ensures Rapid Onset of Action." African Journal of Pharmaceutical Sciences 4, no. 1 (2024): 22–37. http://dx.doi.org/10.51483/afjps.4.1.2024.22-37.

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18

Stahl, Stephen M. "Mechanism of action of ketamine." CNS Spectrums 18, no. 4 (2013): 171–74. http://dx.doi.org/10.1017/s109285291300045x.

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ISSUE:Ketamine induces rapid-onset and short-duration improvement in depressive and suicidal symptoms in both treatment-resistant unipolar depression and bipolar depression, and also reduces chronic pain after short intravenous infusions. In order to develop long-acting oral agents with the same clinical effects, the pharmacologic mechanism of action must be understood, and the leading hypotheses are discussed here.

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19

Arthur, Annette O., and Peyton Holder. "A Review of Transbuccal Fentanyl Use in the Emergency Department." Pain Research and Treatment 2012 (March 20, 2012): 1–3. http://dx.doi.org/10.1155/2012/768796.

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Patients with severe, painful injuries and illnesses treated in the emergency department are commonly administered opioid medications. Intravenous administration provides the most rapid onset of pain relief and is readily titrated. Fentanyl, administered intravenously, is well documented as an effective medication for pain management in the emergency department. It is preferred in many settings due to its minimal hemodynamic effects, as compared to other commonly used opioids. However, not all patients require intravenous access. These patients are given orally administered pain medications. T

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20

Berk, Michael, Collen Loo, Christopher G. Davey, and Brian H. Harvey. "Ketamine and rapidly acting antidepressants: Breaking the speed of sound or light?" Australian & New Zealand Journal of Psychiatry 52, no. 11 (2018): 1026–29. http://dx.doi.org/10.1177/0004867418783567.

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There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available psychotropic agents and whether this is mutable with emerging agents with potential rapid onset, in particular ketamine.

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21

&NA;. "Inhaled apomorphine [VR004] improves erectile dysfunction with a rapid onset of action,." Inpharma Weekly &NA;, no. 1397 (2003): 13. http://dx.doi.org/10.2165/00128413-200313970-00034.

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22

STOKES, T. C., and G. FEINBERG. "Rapid onset of action of levocabastine eye-drops in histamine-induced conjunctivitis." Clinical Experimental Allergy 23, no. 9 (1993): 791–94. http://dx.doi.org/10.1111/j.1365-2222.1993.tb00368.x.

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23

Yu, Y., Y. Shu, and D. A. McCormick. "Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics." Journal of Neuroscience 28, no. 29 (2008): 7260–72. http://dx.doi.org/10.1523/jneurosci.1613-08.2008.

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24

Ashok, Kumar Sharma, Pushpendra Singh Naruka Dr., Shankar Soni Mr., Mohit Khandelwal Mr., Shaneza Aman Ms., and Mehul Mr. "SUBLINGUAL TABLET- ADVANCEMENT IN TABLET DOSAGES FORM." International Journal of Current Pharmaceutical Review and Research 11, no. 2 (2019): 01–05. https://doi.org/10.5281/zenodo.12672960.

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Sublingual drug delivery is often an alternate and better choice of route in comparison to oraldrug delivery as sublingually administered dosage forms bypass hepatic metabolism. A rapidonset of pharmacological effect is usually desired for a few drugs, especially those utilizedin the treatment of acute disorders and need onset of action. Sublingual tablets disintegraterapidly and therefore the bit of saliva present is typically sufficient for achievingdisintegration of the dosage form including better dissolution and increased bioavailabilitywith effective therapeutic range. Sublingual tablets

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25

Aldohbeyb, Ahmed A., and Ahmad O. Alokaily. "Cortical Neurons Adjust the Action Potential Onset Features as a Function of Stimulus Type." Applied Sciences 13, no. 18 (2023): 10158. http://dx.doi.org/10.3390/app131810158.

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Pyramidal neurons and interneurons play critical roles in regulating the neuronal activities in the mammalian cortex, where they exhibit different firing patterns. Pyramidal neurons mainly exhibit regular-spiking firing patterns, while interneurons have fast-spiking firing patterns. Cortical neurons have distinct action potential onset dynamics, in which the evoked action potential is rapid and highly variable. However, it is still unclear how cortical regular-spiking and fast-spiking neurons discriminate between different types of stimuli by changing their action potential onset parameters. T

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26

Kucera, Michelle L., and John P. Graham. "Insulin Lispro, a New Insulin Analog." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 18, no. 3 (1998): 526–38. http://dx.doi.org/10.1002/j.1875-9114.1998.tb03116.x.

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Insulin lispro is a rapid‐acting insulin analog to regular insulin. Inversion of the proline‐lysine amino acid sequence at positions 28 and 29 on the B chain is responsible for its more rapid absorption, faster onset, and shorter duration of action compared with regular insulin. The fast onset of action allows for greater flexibility in dosing and mealtime scheduling. Insulin lispro provides equivalent or slightly improved glycemic control in patients with types I and II diabetes mellitus compared with regular insulin, without subsequent increases in hypoglycemic episodes. It also results in g

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27

Machado-Vieira, Rodrigo, Giacomo Salvadore, Nancy DiazGranados, and Carlos A. Zarate. "Ketamine and the next generation of antidepressants with a rapid onset of action." Pharmacology & Therapeutics 123, no. 2 (2009): 143–50. http://dx.doi.org/10.1016/j.pharmthera.2009.02.010.

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28

Wang, Ke, Xin-Kuan Liu, Xiao-Hong Chen, Deng-Guang Yu, Yao-Yao Yang, and Ping Liu. "Electrospun Hydrophilic Janus Nanocomposites for the Rapid Onset of Therapeutic Action of Helicid." ACS Applied Materials & Interfaces 10, no. 3 (2018): 2859–67. http://dx.doi.org/10.1021/acsami.7b17663.

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29

Quevedo, João, Clarissa M. Comim, and Elaine C. Gavioli. "Ketamine induces rapid onset of antidepressant action: neurophysiological biomarkers as predictors of effect." Biomarkers in Medicine 3, no. 1 (2009): 5–8. http://dx.doi.org/10.2217/17520363.3.1.5.

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30

Simon, RPh, MD, Steven M., and Lee S. Schwartzberg, MD, FACP. "A review of rapid-onset opioids for breakthrough pain in patients with cancer." Journal of Opioid Management 10, no. 3 (2014): 207. http://dx.doi.org/10.5055/jom.2014.0209.

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Pain management in patients with cancer remains suboptimal. Breakthrough pain (BTP) is characterized by abrupt onset of severe pain in a background of otherwise stable managed pain and presents a substantial burden to patients, as it disrupts activities and quality of life. Rapid-onset opioids (ROOs), with an appropriate onset and duration of effect, provide new options for effective and well-tolerated management of BTP. All currently available ROOs are various formulations of transmucosal immediate-release fentanyl (TIRF) and, although they were originally developed and approved for use in ch

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31

Lötvall, Jan, Helen Lunde, and Nils Svedmyr. "Onset of Bronchodilation and Finger Tremor Induced by Salmeterol and Salbutamol in Asthmatic Patients." Canadian Respiratory Journal 5, no. 3 (1998): 191–94. http://dx.doi.org/10.1155/1998/364639.

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Salmeterol is a beta-agonist with bronchodilator properties that last for at least 12 h after inhalation. However, the onset of action of salmeterol immediately after inhalation has not been sufficiently investigated. In the present study, the onset of action and tremor-inducing effect of two doses of inhaled salmeterol (50 and 100 µg) were compared with inhaled salbutamol (200 and 400 µg) and placebo. Lung function was measured using forced expiratory volume in 1 s (FEV), and tremor was measured using a linear accelerometer. With salbutamol there was rapid bronchodilation, both doses producin

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32

Mukul, Malpure* Aniket Gudur Rini Punathil Sanket Dharashivkar. "A Review on Sublingual Tablets: An Efficient Alternative for Drug Administration." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1408–18. https://doi.org/10.5281/zenodo.14882066.

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Oral mucosal drug delivery is a novel route for systemic drug delivery, which not only has many advantages but also has many potentials. Sublingual, meaning "under the tongue," is the method of drug administration in which the drug substance is placed under the tongue alone for rapid absorption through the vessels beneath the tongue. The sublingual route bypasses hepatic first-pass metabolic processes, which results in better bioavailability, faster onset of action, and greater patient compliance. If sublingual medications are used, the onset of action is faster than that expected for orally a

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33

Clavijo, Claudia F., Rachael Rzasa Lynn, Uwe Christians, and Jeffrey L. Galinkin. "Intranasal Fentanyl for Breakthrough Pain Control." Clinical Medicine Insights: Therapeutics 4 (January 2012): CMT.S7298. http://dx.doi.org/10.4137/cmt.s7298.

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Breakthrough pain (BTP) is experienced by approximately 65% of children and adults with chronic pain. Undiagnosed or untreated BTP produces negative emotional, physical, and economic consequences. BTP episodes have a rapid onset and short duration. Short acting oral opioids are the cornerstone of BTP management. Oral medications available to treat BTP episodes like immediate-release morphine or oxycodone have a delayed onset of action so that there is a mismatch between the episode of BTP and the effect of the oral opioids. Novel fentanyl delivery systems for BTP offer pharmacokinetic properti

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34

Bristow, Michael R., Dale G. Renlund, Edward M. Gilbert, Howard R. Lee, William A. Gay, and John B. O'Connell. "Murine monoclonal CD‐3 antibody in cardiac transplantation: Antirejection treatment and preliminary results in a prospectively randomized trial for prophylaxis." Clinical Transplantation 2, no. 4 (1988): 163–68. http://dx.doi.org/10.1111/j.1399-0012.1988.tb00498.x.

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The murine monoclonal CD‐3 antibody (OKT*3) is a useful new addition to the pharmacologic immunosuppressive armamentarium available to the cardiac transplant clinician. Its advantages include its powerful effect, potency and ease of administration, rapid onset of action, narrow immunosuppressive spectrum and, because of its biologic source, a guaranteed supply. Disadvantages include potentially serious reactions related to mediator release and relatively rapid onset of sensitization, compromising repeat use of the agent. The details of how to best use OKT*3 still remain to be elucidated, parti

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35

Stahl, Stephen M. "Mechanism of action of dextromethorphan/quinidine: comparison with ketamine." CNS Spectrums 18, no. 5 (2013): 225–27. http://dx.doi.org/10.1017/s109285291300062x.

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ISSUE:Reports of rapid-onset but short-duration antidepressant effects in patients with treatment-resistant mood disorders after intravenous administration of ketamine have prompted efforts to find an agent with ketamine's properties that can be administered orally in repeated doses in order to sustain that action. One candidate for this is dextromethorphan, and here the pharmacologic mechanism of action is compared and contrasted with that of ketamine.

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36

Lang, Bing-Chen, Jun Yang, Yu Wang, et al. "An Improved Design of Water-Soluble Propofol Prodrugs Characterized by Rapid Onset of Action." Survey of Anesthesiology 58, no. 6 (2014): 304–5. http://dx.doi.org/10.1097/sa.0000000000000095.

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37

Lucas, Guillaume, Vladimir V. Rymar, Jenny Du, et al. "Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action." Neuron 55, no. 5 (2007): 712–25. http://dx.doi.org/10.1016/j.neuron.2007.07.041.

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38

Lang, Bing-Chen, Jun Yang, Yu Wang, et al. "An Improved Design of Water-Soluble Propofol Prodrugs Characterized by Rapid Onset of Action." Anesthesia & Analgesia 118, no. 4 (2014): 745–54. http://dx.doi.org/10.1213/ane.0000000000000124.

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39

Berrade, Luis, Bárbara Aisa, María J. Ramirez, et al. "Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action." Journal of Medicinal Chemistry 54, no. 8 (2011): 3086–90. http://dx.doi.org/10.1021/jm2000773.

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40

Artigas, Francesc. "Limitations to enhancing the speed of onset of antidepressants ? are rapid action antidepressants possible?" Human Psychopharmacology: Clinical and Experimental 16, no. 1 (2001): 29–36. http://dx.doi.org/10.1002/hup.180.

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41

Arthur, RMF, and H. Mehmel. "A SUSTAINED RELEASE FORMULATION OF ISOSORBIDE‐5‐MONONITRATE WITH A RAPID ONSET OF ACTION." International Journal of Clinical Practice 53, no. 3 (1999): 205–12. http://dx.doi.org/10.1111/j.1742-1241.1999.tb11704.x.

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42

AL Sheikh, Shihab. "Single-Shot Sub-Dissociative Dose Ketofol versus Ketamine Alone for Emergency Department Procedural Sedation and Analgesia in Adult." Emergency Medicine, Trauma and Surgical Care 8, no. 1 (2021): 1–9. http://dx.doi.org/10.24966/ets-8798/100058.

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When compared with Ketamine alone for PSA in ED settings, the Ketofol with rapid onset of action, faster recovery time, cardio respiratory stability, less adverse events, and high patient satisfaction level make it a better option.

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43

Poddar, Shives. "RAPID DISSOLUTION: DEVELOPMENT AND ASSESSMENT OF A NOVEL DRUG FORMULATION." American Journal of Medical Sciences and Pharmaceutical Research 06, no. 05 (2024): 01–05. http://dx.doi.org/10.37547/tajmspr/volume06issue05-01.

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This study focuses on the development and assessment of a novel fast-dissolving drug formulation aimed at improving drug delivery efficiency and patient compliance. The formulation was designed to dissolve rapidly in the oral cavity, facilitating quick absorption and onset of action. Through a systematic approach, the formulation's composition, including excipients and active pharmaceutical ingredients, was optimized to achieve rapid dissolution while maintaining stability and bioavailability. Various techniques, such as direct compression, freeze-drying, and spray drying, were explored to pro

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44

Ibrahim, Hamza Khalifa, Abdulfatah Saed, Naser Ramdan R. Amaizah, Aejeeliyah Yousuf, and Malak Abdalh Akim Esdera. "The effect of lidocaine when used as a local anesthetic or by intravenous injection." Science Progress and Research 1, no. 4 (2021): 234–37. http://dx.doi.org/10.52152/spr/2021.138.

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The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and an intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for spinal and peridural anesthesias, however, lidocaine, on the other hand, has the advantage of a rapid onset of action. Adrenaline supplements could delay the resorption and the duration of efficacy could be doubled. Lidocaine is the most important class 1B antiarrhythmic drug: it is used intrave

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45

Patané, Ivan, Lucilla Cardinali, Romeo Salemme, Francesco Pavani, Alessandro Farnè, and Claudio Brozzoli. "Action Planning Modulates Peripersonal Space." Journal of Cognitive Neuroscience 31, no. 8 (2019): 1141–54. http://dx.doi.org/10.1162/jocn_a_01349.

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Peripersonal space is a multisensory representation relying on the processing of tactile and visual stimuli presented on and close to different body parts. The most studied peripersonal space representation is perihand space (PHS), a highly plastic representation modulated following tool use and by the rapid approach of visual objects. Given these properties, PHS may serve different sensorimotor functions, including guidance of voluntary actions such as object grasping. Strong support for this hypothesis would derive from evidence that PHS plastic changes occur before the upcoming movement rat

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46

Gendolla, A. "Clinical Profile and Practice Experience of Almotriptan." Cephalalgia 24, no. 2_suppl (2004): 16–23. http://dx.doi.org/10.1111/j.1468-2982.2004.00894.x.

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Patients expect their acute migraine treatment to have a rapid onset of action, achieve complete pain relief that is sustained for 24 h, and to have a good tolerability profile. Almotriptan has a favourable pharmacokinetic profile that translates clinically to a rapid onset of action and consistent absorption regardless of age, sex, food intake and status of the acute migraine attack. In addition, almotriptan is not associated with any clinically relevant drug-drug interactions. Pain-free status at 2 h postdose is achieved by approximately 39% of patients receiving almotriptan in clinical tria

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47

Nair, MD, Abhijit S. "The ideal opioid: Is oliceridine the answer?" Journal of Opioid Management 12, no. 6 (2016): 375. http://dx.doi.org/10.5055/jom.2016.0356.

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There is no ideal opioid available in present clinical practice. Characteristics of an ideal opioid should be rapid onset of action, short acting, minimal respiratory depression, least peripheral side effects like constipation, urinary retention and devoid of dependence or tolerance with chronic use.

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48

Gadekar, Nilesh Shivaji, Sakshi Machhindra Gaikwad, and Swati Bhagwan Katkar. "Review on Sublingual Tablet." International Journal for Research in Applied Science and Engineering Technology 12, no. 1 (2024): 1358–63. http://dx.doi.org/10.22214/ijraset.2024.58175.

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Abstract: Objective: As sublingually given dose forms avoid hepatic metabolism, sublingual medication delivery can be an alternate and superior method to oral drug delivery. For some medications, particularly those prescribed for the treatment of acute diseases, a quick onset of pharmacological activity is frequently required. Sublingual pills dissolve quickly, and the major saliva available is typically enough to achieve dosage form disintegration along with enhanced dissolving and increased bioavailability. Findings: Comparing sublingual pills to traditional dosage forms, it was discovered t

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49

&NA;. "Escitalopram appears to have a more rapid onset of action than other SSRIs and venlafaxine,." Inpharma Weekly &NA;, no. 1528 (2006): 15. http://dx.doi.org/10.2165/00128413-200615280-00032.

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50

Grosjean, P., F. Hurbin, C. Jan, Z. Guo, and A. Moryusef. "Rapid onset and offset of action of otamixaban, a potent direct intravenous factor Xa inhibitor." European Heart Journal 34, suppl 1 (2013): P4845. http://dx.doi.org/10.1093/eurheartj/eht310.p4845.

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