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Relevant bibliographies by topics / Rat behaviour research / Dissertations / Theses

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Dissertations / Theses on the topic 'Rat behaviour research'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Cole, B. J. "An analysis of the behavioural functions of the coeruleo-cortical noradrenergic projection." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233727.

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This thesis investigates the behavioural functions of the ascending noradrenergic projections from the locus coeruleus to forebrain regions such as the neocortex and hippocampus in the dorsal noradrenergic ascending bundle (DNAB). The behavioural effects of lesions to the DNAB were assessed during the neurotoxin 6-hydroxydopamine, which reduces cortical NA levels to about 5 percent of control values. The neuroanatomical specificity of the behavioural deficits was also assessed, either through comparison with the effects of lesions in the trajectory of the lateral tegmental NA cell bodies (vent

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2

McGregor, Alison. "The contribution of the amygdaloid complex to the socio-sexual behaviour of the male rat." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385709.

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Clark, Callie Anne Marie, and University of Lethbridge Faculty of Arts and Science. "Sound-induced behavioural activation in the normal and haloperidol-treated rat." Thesis, Lethbridge, Alta. : University of Lethbridge, Canadian Centre for Behavioural Neuroscience , c2008, 2008. http://hdl.handle.net/10133/1293.

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Diseases of the central and peripheral nervous systems affect one in five people in North America. Parkinson’s disease (PD) is the second most common neurodegenerative disease, after Alzheimer’s disease, and occurs in approximately 1% of the general North American population. PD is a progressive movement disorder that is characterized by resting tremor, rigidity, bradykinesia (slowness of movement) or akinesia (absence of spontaneous movement), as well as postural instability. Current treatment of PD is symptom-based, and no pharmacological treatment currently exists to slow the progression of

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4

Nemati, Farshad, and University of Lethbridge Faculty of Arts and Science. "Contribution of brain with or without visual cortex lesion to exploratory locomotion in the rat." Thesis, Arts and Science, 2008. http://hdl.handle.net/10133/665.

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Over the past five decades spatial behavior has been a subject of research interest in psychology and neuroscience, in part based on philosophical theories of mental spatial representations. In order to continue uncovering the facts regarding spatial behavior, the focus of this thesis was on the contribution of entry point and visual inputs to the organization of exploratory locomotion and spatial representation in the rat. Despite the contribution of the hippocampus to spatial abilities, the exploratory locomotion is still visually organized in rats with damage to the hippocampus. On the othe

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5

Hines, Dustin J., and University of Lethbridge Faculty of Arts and Science. "The role of cues and the hippocampus in home base behaviour." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004, 2004. http://hdl.handle.net/10133/646.

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The thesis examines the ability of animals to construct a home base. The home base is a point in space where animals rear, groom, and circle and is a primary element in organized spatial behaviour (Eilam and Golani 1989). Once animals establish a home base, they make outward trips and stops, and after a series of trips and stops they return again to the home base. The home base behaviour of animals acts as a platform for asking questions about the cognitive organization of an environment. The thesis describes five main findings. Control and hippocampectomized animals use (1) proximal and (2) d

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6

Grodecki, Joseph. "Behavior of Glioblastoma Cells in Co Culture with Rat Astrocytes on an Electrospun Fiber Scaffold." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338321595.

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7

Gharbawie, Omar A., and University of Lethbridge Faculty of Arts and Science. "The role of cholinergic and serotonergic neocortical projections in controlling skilled movement in rats : evaluation of a model of dementia." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2002, 2002. http://hdl.handle.net/10133/177.

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The ascending cholinergic and serotonergic projections are central to cortical activation and normal behavior. The objective of this thesis was to determine whether unilaterally damaging both of these systems would disrupt the production of skilled movements on the contralateral side of the body. Rats received unilateral damage to either the ascending cholinergic, or serotonergic, or both projections. The respective lesions reduced neocortical leveles of acetylcholine and serotonin as assessed by acetylcholinesterase reactivity and immunohistochemical staining for serotonin. Subjects were asse

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Himmler, Brett T., and University of Lethbridge Faculty of Arts and Science. "The effect of playful experiences on the plasticity and metaplasticity of the brain." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2011, 2011. http://hdl.handle.net/10133/3081.

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The influence of play behavior on the brain was investigated through plasticity and metaplasticity methodology. Regions in both cortical and sub-cortical areas were investigated. Animals in both studies either experienced play with juvenile partners or did not experience play by being paired with an adult. Play experience alone was shown to affect the plasticity in the prefrontal cortex, although it did not show structural changes to sub-cortical regions. If animals were given nicotine after play experiences, the affects of play in the prefrontal cortex were abolished. In addition, playful beh

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9

Jones, Nicholas. "Unconditioned escape behaviour in rats : implications for pre-clinical research into pathological extreme anxiety disorders." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401778.

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10

Asiminas, Antonios. "Modelling fragile X syndrome in rats : new directions in translational research." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23634.

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Fragile X syndrome (FXS) is the leading single gene cause of intellectual disability and Autism Spectrum Disorder (ASD). It is caused by epigenetic silencing of the fragile X mental retardation gene (FMR1), causing a loss of Fragile-X Mental Retardation Protein (FMRP). Over the last 2 decades, much has been learned about the pathophysiology related to the loss of FMRP from mouse models of FXS. The recent generation of a rat model of FXS opens the door to: validate phenotypes across mammalian species, address cognitive dysfunction using paradigms that are more difficult to address in mice and e

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Holec, Victoria, and University of Lethbridge Faculty of Arts and Science. "Role of rat anterior cingulate cortex in effort- and courage-based decision making." Thesis, Lethbridge, Alta. : University of Lethbridge, [Dept. of] Neuroscience, c2013, 2013. http://hdl.handle.net/10133/3433.

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When given a choice between getting a high reward that requires climbing a high ramp or pressing a lever multiple times, versus freely obtaining a low reward, healthy rats prefer the former, while rats with lesions to the anterior cingulate cortex (ACC) prefer the latter. We developed two novel effort tasks to examine if ACC mediates other types of physical effort (weight-lifting) as well as emotional effort (courage). We replicated previous findings on a modified version of the ramp-climbing task, showing that ACC lesions impair these decisions. Lesions of ACC did not impair weight-lifting ef

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Chen, Feng 1963. "Behavioural and neurochemical characterisation of central 5-HT systems in alcohol-preferring fawn-hooded rats." Monash University, Dept. of Pharmacology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8311.

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13

Faraji, Jamshid, and University of Lethbridge Faculty of Arts and Science. "Structural alterations in the hippocampus and spatial behavior by stress in male and female rats : protections, and recovery in water-based and dry-land tasks." Thesis, Lethbridge, Alta : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/725.

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Stress-related cognitive changes are still a matter of debate. In some particular neuropathological conditions such as focal ischemia, cognitive functions have been shown to be significantly impaired. These conditions, however, may be improved by some factors such as steroid hormones. The purpose of the current thesis was to assess the structural and functional effects of corticosterone-related experiences on the hippocampus before and after endothelin-1 (ET-1)-induced stroke. We found corticosterone-related experiences enhance the hippocampal recovery, and improve its function in both wet and

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14

Spanswick, Simon, and University of Lethbridge Faculty of Arts and Science. "A behavioural analysis of visual pattern separation ability by rats : effects of damage to the hippocampus." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005, 2005. http://hdl.handle.net/10133/236.

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Different events usually contain similar elements that can contribute to interference during memory encoding and retrieval. The hippocampus (HPC), a structure that is critically involved in some forms of memory, has been hypothesized to reduce interference between memories with overlapping content, thus facilitating correct recall. Pattern separation is one hypothetical process whereby input ambiguity is reduced. Here we test the hypothesis that the HPC and/or dentate gyrus (DG) are important for pattern separation by measuring performance by rats with damage in tasks that require discriminati

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Goldsbury, Robin Paulette, and University of Lethbridge Faculty of Arts and Science. "Early unilateral olfactory bulb lesion results in diffuse changes in behavior and overall cortical organization." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007, 2007. http://hdl.handle.net/10133/683.

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The current work explores the behavioural and anatomical consequences of unilateral neonatal bulbectomy (OBX) in male and female rats at postnatal day 1 (PI) and P10. In adulthood the animals underwent a battery of motor and cognitive tests, and diffuse effects of early brain injury on the development of behavior were found. Disturbing olfactory sense input during development affected motor output. Rats normally display an equal distribution of right or left paw preference. In this study, both OBX sexes showed a shifted paw preference to the ipsilesional side, and forelimb deficits were found

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16

Gensel, John Carib. "Modeling and treatment of rat cervical spinal cord injury." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1167753874.

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Wielewski, Euan. "An investigation into the effects of microstructure and texture on the high strain rate behaviour of Ti-6Al-4V." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e34d77ae-922d-4f87-a8ab-53da0e5d6e8a.

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The core aim of this research project was to improve understanding of the effects of microstructure and crystallographic texture on the high strain rate plastic deformation behaviour of the industrially important Titanium alloy, Ti-6Al-4V. To facilitate this study, four rolled plates of Ti-6Al-4V, with varying thermo-mechanical processing histories, were provided by TIMET Corp., the world’s largest supplier of Titanium product. To determine the nature of each plate’s microstructure and the crystallographic texture of the dominant α phase, the four Ti-6Al-4V plates were microstructurally charac

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18

Field, Evelyn F., and University of Lethbridge Faculty of Arts and Science. "Sex differences in movement organization II : the organization of sex differences in movement during food protection, contact righting, skilled reaching and vertical exploration in the rat : the role of gonadal steroids, body morphology, and the central nervous system." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006, 2006. http://hdl.handle.net/10133/14.

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Whether there are sex differences in the kinematic organization of non-reproductive behaviors is rarely addressed. In this thesis, evidence is presented that male and female rats organize their posture and stepping differently during a food protection task, contact righting, skilled reaching, and vertical rearing. Neonatal gonadal steroid exposure can alter sex-typical patterns of movement organization. Whether these differences are due to sex differences in body morphology or central nervous system (CNS) was also addressed using gravid females and tfm males. The results reveal that sex di

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Löfgren, Magnus. "Behavioral effects of female sex steroid hormones : models of PMS and PMDD in Wistar rats." Doctoral thesis, Umeå universitet, Obstetrik och gynekologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22557.

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Background Animal models can be used to mimic human conditions of psychopathology, and also as pre-clinical models to evaluate candidate drugs. With hormonal treatment it is possible to produce behavior in the rat which corresponds to the mental symptoms of pre-menstrual syndrome (PMS), and pre-menstrual dysphoric disorder (PMDD). PMS affects 25-30 % of all women in fertile age and 3-8% are diagnosed with the more severe condition PMDD. The cardinal mental symptoms are; irritability, mood-swings, depression, anxiety, fatigue, insomnia, difficulties with concentration and memory and learning di

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Bell, Heather C., and University of Lethbridge Faculty of Arts and Science. "Playful feedback and the developing brain." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/747.

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The prefrontal cortex (PFC) has long been thought to be the seat of social behaviours in mammals. Lesions of the orbitofrontal cortex (OFC), a subregion of the PFC, are known to cause social deficits in humans. Interestingly, social deficits are also seen in rats with OFC lesions. Rats that are deprived of peer play during development exhibit behaviour similar to OFC-ablated animals. Another subregion of the PFC, the medial prefrontal cortex (mPFC) is interconnected with the OFC. The mPFC and OFC have been shown to be reciprocally responsive to a variety of inuences, in terms of dendritic morp

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Ferreira, Juliana de Souza. "Comportamentos novos originados a partir da interconexão de repertórios previamente treinados: uma replicação de Epstein, Kirshnit, Lanza e Rubin, 1984." Pontifícia Universidade Católica de São Paulo, 2008. https://tede2.pucsp.br/handle/handle/16828.

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Made available in DSpace on 2016-04-29T13:18:09Z (GMT). No. of bitstreams: 1 Juliana de Souza Ferreira.pdf: 3589110 bytes, checksum: c8e5dedeebec46a11c8bc2a721d030a0 (MD5) Previous issue date: 2008-05-09<br>The present study replies Epstein, Kirshnit, Lanza and Rubin s (1984) research in which pigeons solved a problem by pushing a box beneath an unattainable target, climbing this box and pecking the target. It was investigated if new behaviors emerge from the interconnection of two trained repertoires with rats and if changes in the sequence order in which these two repertoires was taught wo

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Mages, Linda. "RAP 'n CAB : research and partnership in Cardiff and Bristol : an in depth exploration of perspectives held by boys who have social emotional behavioural difficulties on their lifestyle, health and access to health-related services using a music-based approach." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555744.

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An in depth exploration of perspectives held by boys who have social emotional behavioural difficulties (SEBDs) on their lifestyle, health and access to health-related services using a music-based approach. RAP ‘n CAB is a collaborative exploratory study between 2 secondary schools asking what perspectives boys with SEBDs hold on their lifestyle, health and access to health-related help. The methodology is qualitative using a participative approach involving peer researchers to collect data. Using purposive sampling, eight boys aged 14 years consented to participate on invitation by their teac

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Shahadha, Saadi Sattar. "Measured Soil Hydraulic Properties as RZWQM2 Input to Simulate Soil Water Dynamics and Crop Evapotranspiration." UKnowledge, 2018. https://uknowledge.uky.edu/pss_etds/110.

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Agricultural system models integrate many different processes that cannot all be measured in field experiments and help quantify soil water dynamics, crop evapotranspiration, and crop growth with high temporal resolution. Understanding soil water dynamics and crop evapotranspiration is essential to improve agricultural management of field crops. For example, the interaction between nitrogen application rate and water dynamics is not sufficiently understood. In most cases, model simulations deviate from field measurements, especially when model input parameters are indirectly and unspecifically

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Nyh, Johan. "From Snow White to Frozen : An evaluation of popular gender representation indicators applied to Disney’s princess films." Thesis, Karlstads universitet, Institutionen för geografi, medier och kommunikation, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-36877.

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Simple content analysis methods, such as the Bechdel test and measuring percentage of female talk time or characters, have seen a surge of attention from mainstream media and in social media the last couple of years. Underlying assumptions are generally shared with the gender role socialization model and consequently, an importance is stated, due to a high degree to which impressions from media shape in particular young children’s identification processes. For young girls, the Disney Princesses franchise (with Frozen included) stands out as the number one player commercially as well as in cust

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Leung, Vivian. "Advancing pain research and animal welfare: focusing on the Rat Grimace Scale and reporting standards." Thèse, 2018. http://hdl.handle.net/1866/22589.

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Windisch, Kyle Allyson. "ACHIEVING PHARMACOLOGICALLY RELEVANT IV ALCOHOL SELF-ADMINISTRATION IN THE RAT." Thesis, 2012. http://hdl.handle.net/1805/2978.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Alcohol consumption produces a complex array of effects that can be divided into two types: the explicit pharmacological effects of ethanol (which can be quite separate temporally from time of intake) and the more temporally “relevant” effects (primarily olfactory and taste) that bridge the time from intake to the onset of the pharmacological effects. Dissociating these effects is essential to untangling the neurologic underpinnings of alcohol abuse and dependence. Intravenous self-administration of ethanol allows for controlled and

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Joseph, Sithole Makgamathe. "Hydrogen and Muonium behaviour in diamond." Diss., 2005. http://hdl.handle.net/10500/2109.

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This work is aimed at the understanding of the dynamical behavior of hydrogen in diamond. The investigation was carried out using Transverse Field muon Spin Rotation (TF-SR) and the Longitudinal Field muon Spin Relaxation (LF-SR) techniques. The chemical analogy between hydrogen (p+e-) and muonium (u+e-) enabled the study of the indirect dynamical behavior of hydrogen in diamond. The TF-SR and LF-SR measurements were carried out in an isotopically pure 13C diamond in the temperature ranges 11 mK - 320 K and 10 K - 400 K, respectively. In the TF-SR results, the Prompt Absolute Fraction (

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Bracken, Amy L. "Effects of Nicotine Exposure in Adolescent Rats on Acquisition of Alcohol Drinking and Response to Nicotine in Adulthood." Thesis, 2009. http://hdl.handle.net/1805/1950.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Nicotine is one of the most widely abused drugs in the world, and most smokers begin smoking during their adolescent years. Adolescence is a unique developmental period during which vulnerability to the effects of drug exposure is especially high. This dissertation uses rodent models to investigate the persistent effects of adolescent nicotine exposure on both neurobiological and behavioral measures of drug sensitivity in adulthood. The aims of this dissertation were to 1) determine whether nicotine would be self-administered into

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Weichelt, Ryan Douglas. "Scale factors in Hispanic voting behavior." 2008. http://proquest.umi.com/pqdweb?did=1568973621&sid=6&Fmt=2&clientId=14215&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Nebraska-Lincoln, 2008.<br>Title from title screen (site viewed Dec. 15, 2008). PDF text: xviii, 376 p. : maps (some col.) ; 6.92 Mb. UMI publication number: AAT 3315158. Includes bibliographical references. Also available in microfilm and microfiche formats.

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Watt, Sandra Jean. "Exploratory behavior in rats with hippocampal damage a research report submitted in partial fulillment ... for the degree of Master of Science(Medical-Surgical Nursing) ... /." 1992. http://catalog.hathitrust.org/api/volumes/oclc/68796353.html.

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31

Bertholomey, Megan Lee. "ALTERATIONS IN THE SEEKING AND SELF-ADMINISTRATION OF ETHANOL AND ANXIETY-LIKE BEHAVIOR FOLLOWING EXPOSURE TO YOHIMBINE IN RATS SELECTIVELY BRED FOR HIGH ALCOHOL INTAKE." Thesis, 2011. http://hdl.handle.net/1805/2617.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Stress has been shown to contribute to alcohol drinking; however, inconsistencies in both the clinical and pre-clinical literature speak to the need for better paradigms to study this interaction. The present experiments compared animal models of the propensity to consume ethanol, the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) rat lines, in their response to yohimbine on ethanol seeking and self-administration and anxiety-like behavior. The P and HAD lines consume similar amounts of ethanol, yet differ in

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Gaskins, Denise. "ELUCIDATING MECHANISMS THAT LEAD TO PERSISTENT ANXIETY-LIKE BEHAVIOR IN RATS FOLLOWING REPEATED ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN THE BASOLATERAL AMYGDALA." Thesis, 2012. http://hdl.handle.net/1805/2738.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Anxiety disorders are estimated to impact 1 in 4 individuals within their lifetime. For some individuals, repeated episodes of the stress response leads to pathological anxiety and depression. The stress response is linked to increased levels of corticotropin-releasing factor (CRF) in the basolateral nucleus of the amygdala (BLA), a putative site for regulating anxiety and associative processes related to aversive emotional memories, and activation of CRF receptors in the BLA of rats produces anxiety-like behavior. Mimicking repeated

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Huang, Sheng-Yeh, and 黃盛業. "The Research on Learning Behaviors and Learning Satisfaction Rate of Students in Electrical Engineering Department in Vocational High Schools." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/54da5c.

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碩士<br>國立彰化師範大學<br>工業教育與技術學系<br>107<br>This research is to explore the learning behavior and learning satisfaction of students in electrical engineering department in vocational high schools in Taiwan. This research reviews literatures in learning behavior and learning satisfaction, forming the rationale. The research instrument is the self-designed “Questionnaire of how skill evaluation influences the learning behavior and learning satisfaction of students in electrical engineering department in vocational high schools.” The questionnaire survey uses stratified cluster sampling method, samplin

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Fromes, Gail. "Effects of sex differences and hippocampal lesions on exploratory behaviors and wayfinding performance in rats in a novel environment a research report submitted in partial fulfillment ... /." 1987. http://catalog.hathitrust.org/api/volumes/oclc/68787816.html.

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Marcich, Heather A. "Effects of bilateral hippocampal damage on wayfinding ability in rats a research report submitted in partial fulfillment ... for the degree Master of Science, Community Health Nursing ... /." 1993. http://catalog.hathitrust.org/api/volumes/oclc/68797691.html.

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Beckwith, Steven Wesley. "Increased delay discounting tracks with later ethanol seeking but not consumption." Thesis, 2014. http://hdl.handle.net/1805/4827.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Assessments of delay discounting in rodent lines bidirectionally selected for home cage intake and preference of alcohol have had mixed findings. The current study sought to examine if delay discounting related differentially to alcohol seeking versus and alcohol drinking, two processes underlying alcohol intake and preference. Three strains of rats were utilized to answer this question Long Evans (LE), high alcohol drinking rats (HAD2), and alcohol preferring P rats. All strains were compared in an adjusting amount delay discountin

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Oster, Scott M. "Chronic Ethanol Drinking by Alcohol-preferring Rats Increases the Sensitivity of the Mesolimbic Dopamine System to the Reinforcing and Stimulating Effects of Cocaine." Thesis, 2013. http://hdl.handle.net/1805/3440.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Alcohol and cocaine are commonly co-abused drugs, and those meeting criteria for both cocaine and alcohol use disorders experience more severe behavioral and health consequences than those with a single disorder. Chronic alcohol (ethanol) drinking increased the reinforcing and dopamine (DA) neuronal stimulating effects of ethanol within mesolimbic regions of the central nervous system (CNS) of alcohol-preferring (P) rats. The objectives of the current study were to determine if chronic continuous ethanol drinking produced: (1) altera

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Li, Cheng-Hsun, and 李政勳. "Fabrication and Field Emission Behaviors Research of Highly Vertical-aligned Carbon Nano-tubes and Fast Grown-rate Nano Diamond Films by Microwave Plasma Chemical Vapor Deposition System." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/65660355904011841221.

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碩士<br>義守大學<br>材料科學與工程學系碩士班<br>96<br>The purpose of this work is to synthesize highly vertical-aligned carbon nano-tubes (VACNTs) and fast grown-rate nano-diamond (ND) films with excellent filed emission characteristics by the microwave plasma enhanced chemical vapor deposition (MPCVD) system. The influences of heat pre-treatment, hydrogen plasma etching locations and time on nickel catalyst morphologies were studied. Subsequently, different gas flow rates of hydrogen (H2) and methane (CH4) were used to synthesize CNTs, and the optimal process parameters would be found by observing the reasonab

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Verplaetse, Terril Lee. "Effects of Prazosin Treatment on Ethanol- and Sucrose-Seeking and Intake in P Rats." Thesis, 2012. http://hdl.handle.net/1805/2970.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Background: Previous studies show that prazosin, an α1-adrenergic receptor antagonist, decreases alcohol drinking in animal models of alcohol use and dependence and in alcohol-dependent men. These studies extended previous findings by using a paradigm that allows for separate assessment of prazosin on motivation to seek versus consume ethanol or sucrose in selectively bred rats given acute or chronic prazosin treatment. Methods: Alcohol-preferring P rats were trained to complete an operant response that resulted in access to eithe

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Henderson, Angela Nicole. "Exploring Potential Pharmacologic Treatments for Alcoholism: Can the Use of Drugs Selective for the µ-, δ-, and κ- Opioid Receptors Differentially Modulate Alcohol Drinking?" Thesis, 2013. http://hdl.handle.net/1805/3363.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Naltrexone (NTX) is clinically efficacious at attenuating alcohol intake in non-abstinent alcoholics and, to a lesser extent, craving, independent of intake. While generally regarded as a non-selective opioid antagonist, NTX has been shown to have concentration dependent selectivity with lower doses (< 1.0 mg/kg) selective for the mu receptor and doses exceeding 1.0 mg/kg capable of binding to delta and kappa receptors. Like the mu system, the delta receptor system has also been implicated in mediating the rewarding effects of EtOH.

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Jensen, Meredith. "Characterization of Behavioral Profiles for Inbred P and NP and Congenic P.NP and NP.P Rats." Thesis, 2012. http://hdl.handle.net/1805/2924.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Alcoholism inheritance rates have been estimated as high as 60% in a human population. Many significant features of alcohol dependence have been replicated in rodent animal models of alcoholism, however not in totality. These animal models include inbred preferring (iP) and nonpreferring (iNP) rat types. Congenic rats have been engineered from the iP and iNP strains whereby a P congenic rat has in its genome a well-chosen chromosomal portion taken from an NP rat (P.NP) and, reciprocally, an NP congenic rat has acquired the analogous

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Myers, Mallory Lynn. "Developmental differences in hypothermic and behavioral responses to ethanol treatment in Alcohol Preferring and Non-Preferring Rats." Thesis, 2012. http://hdl.handle.net/1805/2935.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Differences in voluntary consumption of ethanol have been negatively correlated with differences in initial sensitivity and tolerance to ethanol’s pharmacological effects. From this perspective, both adolescent and adult alcohol-nonpreferring (NP) rats would be expected to be initially more sensitive to the sedative and hypothermic effects of ethanol and fail to acquire tolerance to those effects than preferring (P) rats. The first objective of this experiment was to assess alcohol-induced hypothermia and locomotor sedation in adoles

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Robarge, Jason Dennis. "Aromatase inhibitors produce hypersensitivity in experimental models of pain : studies in vivo and in isolated sensory neurons." Thesis, 2014. http://hdl.handle.net/1805/6056.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Aromatase inhibitors (AIs) are the current standard of care for the treatment of hormone receptor positive breast cancer in postmenopausal women. Nearly one-half of patients receiving AI therapy develop musculoskeletal toxicity that is characterized by joint and/or muscle pain and approximately one-fourth of patients discontinue their therapy as a result of musculoskeletal pain. Since there are no effective strategies for prevention or treatment, insight into the mechanisms of AI-induced pain is critical to improve treatment. However

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Hawkins, Raymond Hilary. "Marketing implications of hip-hop culture in the greater Durban area." Thesis, 2010. http://hdl.handle.net/10321/572.

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Dissertation submitted in compliance with requirements for the Master Degree in Technology: Marketing, Durban University of Technology, 2010.<br>Hip-Hop culture has created a lot of interest and controversy around the world. Most people have used and engaged in debates without having a clear understanding of it. Although there are numerous articles to be found on Hip-Hop culture, very little research has been done on this particular topic. The confusion that surrounds Hip-Hop culture highlights the need for marketers to conduct more research on this particular area. This particular study was

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VRZALOVÁ, Monika. "Role sestry ve screeningu deprese u seniorů." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-260905.

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The diploma thesis deals with problems of depression in older people. Mainly the work is focused on identifying and analyzing the role of nurses in screening for depression in older people in primary care, acute care, long-term care and home care. This thesis was focused on theoretical direction and was used the method of design and demonstration. In this thesis was set one main goals with five research questions. The main goal was to identify and analyze the role of nurses in screening for depression in the elderly. RQ 1: What is the role of the nurse in screening for depression in the elderl

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