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Dissertations / Theses on the topic 'Reassortment'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Van, den Bergh Carien. "Reassortment of bluetongue virus vaccine serotypes in cattle." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/53313.

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Bluetongue (BT) is a non-contagious viral disease of domestic and wild ruminants. Bluetongue virus (BTV), an Orbivirus that belongs to the family Reoviridae, is the causing agent of the disease. The virus consists of a ten segmented double stranded (ds) RNA genome and currently 27 serotypes have been identified worldwide. The virus is transmitted by Culicoide biting midges (Diptera: Ceratoponidae) and the occurrence of the disease depends on the presence and abundance of competent vectors. In South Africa most European ovine breeds are more susceptible to the disease than indigenous sheep, whi

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2

Urquidi, Virginia. "Genome segment reassortment between two members of the bunyaviridae." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306612.

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3

Chen, Kuang-Yu. "Mechanistic study and prediction of influenza A virus genetic reassortment." Thesis, Université de Paris (2019-....), 2019. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=4762&f=29825.

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La nature segmentée du génome des virus de la grippe A (IAV) permet une évolution rapide par réassortiment génétique. Bien que le nombre théorique de génotypes issus d'un réassortiment entre deux virus soit de 256 (28), la panoplie complète des différents génotypes n'a jamais été observée et certains gènes ont tendance à co-ségréger, suggérant que le réassortiment génétique est biaisé. Cependant, à ce jour, les contraintes qui façonnent le réassortiment génétique restent largement méconnues. L'objectif de mon projet est de progresser dans la compréhension des règles sous-jacentes au réassortim

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4

Villa, Mara [Verfasser], Michael [Gutachter] Lässig, and Andreas [Gutachter] Beyer. "The role of reassortment in the evolution of seasonal influenza / Mara Villa ; Gutachter: Michael Lässig, Andreas Beyer." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/116372842X/34.

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5

Nindo, Fredrick Nzabanyi. "Exploring the phylodynamics, genetic reassortment and RNA secondary structure formation patterns of orthomyxoviruses by comparative sequence analysis." Doctoral thesis, Faculty of Health Sciences, 2019. https://hdl.handle.net/11427/31729.

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RNA viruses are among the most virulent microorganisms that threaten the health of humans and livestock. Among the most socio-economically important of the known RNA viruses are those found in the family Orthomyxovirus. In this era of rapid low-cost genome sequencing and advancements in computational biology techniques, many previously difficult research questions relating to the molecular epidemiology and evolutionary dynamics of these viruses can now be answered with ease. Using sequence data together with associated meta-data, in chapter two of this dissertation I tested the hypothesis that

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6

Parvin, Rokshana. "Molecular epidemiology and biological properties of avian influenza viruses of subtype H5N1 and H9N2." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-162858.

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Rokshana Parvin Molecular epidemiology and biological properties of avian influenza viruses of subtype H5N1 and H9N2 Institute of Virology Submitted in November 2014 Pages 106, Figures 7, Table 1, References 339, Publications 4 Keywords: Avian Influenza Virus, H5N1, H9N2, Reassortment, Mutation, Replication and Growth kinetics Introduction Avian influenza viruses (AIVs) are the major cause of significant disease outbreaks with high morbidity and mortality worldwide in domestic birds resulting in great economic losses. Especially the subtypes of highly pathogenic avian influenza viruses (HPAIV)

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7

Audsley, Jennifer M., and jennifer audsley@med monash edu au. "Alternative Approaches In The Preparation And Growth Of Influenza B Vaccine Viruses." RMIT University. Applied Sciences, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080414.141937.

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Influenza B viruses are a significant cause of disease and influenza B antigens are present in all human vaccines. Achieving suitable yields of seed viruses is often difficult for vaccine manufacturers. With influenza A viruses increases in yields have been achieved by the preparation of reassortants between a high-yielding donor strain and an epidemic strain. However, reassortment of influenza B viruses for the preparation of seeds has not been usually undertaken due to the lack suitable donor strains. Such an approach, which formed the basis of this thesis, could improve vaccine yields, lowe

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8

Kreibich, Anne [Verfasser]. "Untersuchungen zum Reassortment von aviären und humanen Influenza-A-Viren des Subtyps H3 unter Verwendung der Reversen Genetik. / Anne Kreibich." Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1080382143/34.

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9

Dudas, Gytis. "Inference of evolutionary and ecological processes from reticulate evolution in RNA viruses." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20442.

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RNA viruses have the fastest evolutionary rates amongst protein-coding organisms on the planet. Ease of sequencing, advanced techniques of analysis and global health and economic concerns have all contributed to the recognition of RNA viruses as a robust research platform. Phylogenetic methods have been at the forefront of analytical techniques used to understand the dynamics of RNA viruses - during natural circulation in populations and in individual hosts, within epidemics, across species barriers and over billions of years that viruses have been around. Most of the work presented in this th

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10

Kirsanovs, Sina [Verfasser]. "Genetic reassortment between members of different Dobrava-Belgrade virus lineages and allocation of innate immune response modulation to praticular genome segments / Sina Kirsanovs." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1028494025/34.

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11

Zelnikar, Mojca. "Evolution of drug resistance in influenza A viruses." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/16203.

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Influenza A viruses are important pathogens of humans, other mammals and birds. Swine are considered to be the ‘mixing vessel’ for influenza viruses because of their susceptibility to infection with not only swine influenza viruses but also human and avian influenza viruses. After infection of pigs with different influenza viruses, reassortment events between genomic RNA segments and point mutations can take place which can result in novel influenza virus strains capable of causing human pandemics. To combat infections, vaccination is available in many countries for humans, but not typically u

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12

Suttie, Annika. "The molecular epidemiology of influenza in Cambodia." Thesis, Federation University Australia, 2019. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/173785.

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Avian influenza viruses (AIVs) represent a risk to the health of humans and animals. The prevalence of AIVs in live bird markets in Cambodia is among the highest in the world, being detected in 45.5% of tested poultry in 2015. To better understand the potential risk presented by AIVs, this thesis investigated the genetic characteristics of AIVs circulating in Cambodia between 2014 to 2018; focusing on subtypes that pose the greatest risk to human and animal health (H5, H7 and H9). Highly pathogenic (HP) H5N1 clade 2.3.2.1c viruses and low pathogenic H9N2 BJ/94-like h9-4.2.5 clade viruses were

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13

DI, MARTINO ANGELA. "Genetic characteristics of the influenza A pandemic (h1n1) 2009 virus circulating in Italy." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1386.

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I virus influenzali sono responsabili di epidemie annuali e di più rare pandemie occasionali, che in passato hanno causato la morte di milioni di persone. La comparsa di nuovi ceppi virali rappresenta una continua minaccia per la salute pubblica e una sfida per la comunità scientifica. La recente pandemia influenzale, causata da un virus di sottotipo A/H1N1 di origine suina, costituisce un ulteriore strumento per lo studio dei fattori di virulenza e della diffusione dell'infezione in preparazione a futuri eventi pandemici. Nell'ambito dell’attività di sorveglianza virologica dell'influenza,

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14

Freire, Caio César de Melo. "Caracterização de processos evolutivos de vírus de RNA a partir de padrões deixados nas filogenias virais." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-21012015-165014/.

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No presente trabalho, investigamos a filodinâmica de três modelos virais diferentes, utilizando técnicas baseadas em verossimilhança e inferência bayesiana. Dois desses são flavivírus com genoma de RNA fita simples e senso positivo. O terceiro é um bunyavírus com genoma tri-segmentado de RNA fita simples com senso negativo. Estes diferentes modelos permitiram estudar diferentes mecanismos promotores de diversidade viral, reagrupamento de segmentos genômicos (shift) e mutação (drift), que atuam em diferentes granularidades. Descrevemos pela primeira vez o espalhamento geográfico das linhage

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15

Petersen, Henning [Verfasser]. "Comparative investigations on interspecies adaptation of low-pathogenic avian influenza viruses (AIV) and the impact of NS-reassortment of highly-pathogenic AIV on virus-host interactions in different poultry species / Henning Petersen." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2012. http://d-nb.info/1035195550/34.

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16

Labadie, Thomas. "Stabilité du virus de la grippe dans l'environnement : influence des protéines virales." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC274/document.

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La transmission des virus grippaux de type A s’effectue via l’eau, l’air ou les surfaces. Elle implique donc toujours une étape dans l’environnement, durant laquelle les virus sont inactivés plus ou moins rapidement en fonction du sous-type ou de la souche virale analysés. Cependant, à ce jour, les facteurs moléculaires déterminant la stabilité des particules virales en dehors de l’hôte restent largement méconnus. Dans le but d’identifier ces déterminants, nous avons généré différentes combinaisons de réassortiments entre deux virus grippaux de sous-types H1N1 possédant un phénotype de stabili

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17

Yver, Matthieu. "Étude des mécanismes moléculaires gouvernant le réassortiment génétique et la modulation des glycoprotéines de surface des virus influenza de type A." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10245.

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Le génome des virus influenza de type A est composé de huit segments de gènes (ARNv) de polarité négative retrouvés sous la forme de complexes ribonucléiques (RNPv). L'incorporation sélective des huit RNPv dans les particules virales néosynthétisées se fait par un mécanisme moléculaire qui fait intervenir des signaux d'encapsidation dites « région de packaging ». Nous avons montré que les segments de gènes interagissaient entre eux via des interactions de type ARN/ARN permettant la formation d'un réseau d'interactions. Nous avons de plus montré que les régions de packaging décrites dans la lit

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18

Prisner, Simon. "Deciphering the assembly of multi-segment genome complexes in influenza A virus." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18365.

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Influenza A besitzt ein segmentiertes, achtsträngiges Genom in negativer Orientierung. Die einzelnen Segmente sind in virale Ribonukleoproteinkomplexe (vRNPs) verpackt. Genomische Segmentierung erlaubt es Influenza, zwischen verschiedenen Stämmen Reassortierung zu betreiben, was zur Entstehung von hochgradig virulenten und potentiell pandemischen neuen Stämmen führen kann. Die Existenz eines Packungsmechanismus wird vermutet, der sicherstellt dass exakt ein Segment jeden Typs in neu knospende Viren verpackt wird. Es gibt Indizien dafür, dass die vRNPs während ihres Wegs vom Nukleus zur Plasma

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19

Duff, Michael Alan. "Characterization of H1N2 variant influenza viruses in pigs." Thesis, Kansas State University, 2014. http://hdl.handle.net/2097/17392.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Wenjun Ma<br>With introduction of the 2009 pandemic H1N1 virus (pH1N1) into swine herds, reassortment between the pH1N1 and endemic swine influenza viruses (SIVs) has been reported worldwide. Recently, reassortant H3N2 and H1N2 variant SIVs that contain the M gene from pH1N1 virus and the remaining seven genes from North American triple-reassortant (TR) SIVs have emerged. These variant viruses have caused more than 300 cases of human infections and one death in the USA, creating a major public health concern. To date, the p

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20

Bouscambert-Duchamp, Maude. "Étude du réassortiment génétique des virus influenza d’origines et de sous-types différents." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10084/document.

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Dans le contexte de la menace pandémique liée au virus influenza A(H5N1), un projet «GRIPPE AVIAIRE ET GRIPPE PANDÉMIQUE » a émergé au sein de LyonBioPôle avec comme objectif le développement d’outils de caractérisation des virus influenza pour la production de vaccins. Pour étudier le réassortiment génétique entre virus influenza, nous avons développé 3 systèmes de génétique inverse : virus humain A(H3N2) et aviaires A(H5N2) et A(H5N1) et produit des virus réassortants de composition déterminée. Leurs capacités réplicatives ont été évaluées par cinétiques de croissance virale sur MDCK avec qu

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21

Jere, Khuzwayo Chidiwa. "Whole genome characterisation and engineering of chimaeric rotavirus-like particles using African rotavirus field strains / Khuzwayo Chidiwa Jere." Thesis, North-West University, 2012. http://hdl.handle.net/10394/8502.

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Despite the global licensure of two live-attenuated rotavirus vaccines, Rotarix® and RotaTeq®, rotavirus remains the major cause of severe dehydrating diarrhoea in young mammals and the need for further development of additional rotavirus vaccines, especially vaccines effective against regional strains in developing country settings, is increasing. The design and formulation of new effective multivalent rotavirus vaccines is complicated by the wide rotavirus strain diversity. Novel rotavirus strains emerge periodically due to the propensity of rotaviruses to evolve using mechanisms such as poi

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22

Essere, Boris. "Étude des mécanismes moléculaires gouvernant le réassortiment génétique des virus Influenza de type A." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00867756.

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La grippe, infection respiratoire virale fréquente, est due aux virus Influenza. Leur génome est constitué par huit molécules d'ARN de polarité négative retrouvés sous la forme de complexe ribonucléique (RNPv). Au cours du cycle viral, il a été démontré que les régions terminales des segments de gène étaient cruciales pour l'incorporation sélective des huit RNPv à l'intérieur des particules virales. Par des techniques d'interaction in vitro et de tomographie électronique, nous avons montré que les segments de gène du virus H3N2 interagissaient entre eux par des interactions ARN/ARN impliquant

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23

Gu, Hongcang. "GENETIC DIVERSITY AND SYMPTOM SEVERITY DETERMINANTS OF BEAN POD MOTTLE VIRUS." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_diss/441.

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Bean pod mottle virus (BPMV), a member of the genus Comovirus in the family Comoviridae, is widespread in the major soybean-growing areas in the United States. Soybean yield losses of 10-40% have been reported as a consequence of BPMV infection. The complete nucleotide sequences of two strains, K-Ha1 and K-Ho1, were determined. Field isolates of BPMV were classified into two distinct subgroups (I and II) based on slot blot hybridization and sequence analyses. Full-length cDNA clones from which infectious transcripts can be produced were constructed for strains K-G7, K-Ho1 and K-Ha1. Whereas st

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24

Zhang, Chunquan. "GENETIC DIVERSITY OF BEAN POD MOTTLE VIRUS (BPMV) AND DEVELOPMENT OF BPMV AS A VECTOR FOR GENE EXPRESSION IN SOYBEAN." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/437.

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Bean pod mottle virus (BPMV), a member of the genus Comovirus in the family Comoviridae, is widespread in the major soybean-growing areas in the United States. The complete nucleotide sequences of the genomic RNAs of the naturally occurring partial diploid strain IL-Cb1 were determined. Intermolecular RNA1 recombinants were isolated from strain IL-Cb1 and characterized at the molecular level. Structurally similar recombinant RNA1 was also generated after four passages in soybean derived from plants previously inoculated with a mixture of infectious RNA1 transcripts from two distinct strains. B

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25

Fang, Ho Chun, and 方賀群. "Tracing the Gene Reassortment of Influenza Viruses." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/75108664789605521369.

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碩士<br>長庚大學<br>資訊工程學系<br>99<br>Segments of different influenza viruses could be exchanged when they evolve, which is known as genetic reassortment. Comparing with the small amount of virus “genetic drift” each year due to point mutation accumulation, reassortment is the main reason for a much bigger genetic alteration called “genetic shift”, which generates novel strains that can cause pandemics. Our proposed system takes all eight segments of influenza A virus sequence, we called target sequences, and trace their reassortment origin, if exists, through comparing with abundant database influenz

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26

Allison, Andrew B. "Genetic mechanisms of virus evolution and emergence recombination, reassortment, overprinting and mutation /." 2010. http://purl.galileo.usg.edu/uga%5Fetd/allison%5Fandrew%5Fb%5F201005%5Fphd.

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27

Parvin, Rokshana. "Molecular epidemiology and biological properties of avian influenza viruses of subtype H5N1 and H9N2." Doctoral thesis, 2014. https://ul.qucosa.de/id/qucosa%3A13216.

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Rokshana Parvin Molecular epidemiology and biological properties of avian influenza viruses of subtype H5N1 and H9N2 Institute of Virology Submitted in November 2014 Pages 106, Figures 7, Table 1, References 339, Publications 4 Keywords: Avian Influenza Virus, H5N1, H9N2, Reassortment, Mutation, Replication and Growth kinetics Introduction Avian influenza viruses (AIVs) are the major cause of significant disease outbreaks with high morbidity and mortality worldwide in domestic birds resulting in great economic losses. Especially the subtypes of highly pathogenic avian influenza viruses (HPA

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28

Wang, Zhongfang [Verfasser]. "NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and anti-viral host response / eingereicht von Zhongfang Wang." 2010. http://d-nb.info/1009516167/34.

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29

Mhamdi, Zeineb. "Variations génomiques et antigéniques du virus de la grippe porcine (Influenzavirus porcin) sur le territoire québécois." Thèse, 2016. http://hdl.handle.net/1866/18651.

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A ce jour, les données génétiques et moléculaires se rapportant aux virus influenza de type A (VIs) présents dans la population porcine au Québec sont relativement rares. Pourtant, ces informations sont essentielles pour la compréhension de de l'évolution des VIs à grande échelle de 2011 à 2015. Afin de remédier à ce manque de données, différents échantillons (pulmonaires, salivaires et nasaux) ont été prélevés à partir de 24 foyers dans lesquelles les animaux présentaient des signes cliniques. Ensuite, les souches virales ont été isolées en culture cellulaire (MDCK) ou sur oeufs embryonnés. L

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