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Dissertations / Theses on the topic 'Receptores EP'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Gomes, Renata Nascimento. "Análise do perfil dos prostanoides e do seu papel no controle da migração celular em glioblastoma." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-23012017-094918/.

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O glioblastoma (GBM) é o tumor mais frequente do sistema nervoso central com um alto grau de malignidade e um prognóstico desfavorável. Apesar dos avanços nas técnicas cirúrgicas e de radioterapia e/ou quimioterapia, não há tratamento eficiente disponível para o GBM. Os prostanoide são derivados do ácido araquidônico e estão envolvidas com vários processos do desenvolvimento e progressão do câncer. O objetivo deste estudo foi analisar in vitro o perfil de diferentes prostanoides nas linhagens de GBM. Além de analisar o papel dos prostanoides e dos receptores na migração celular de GBM. Os resu

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2

Reschke, Cristina Ruedell. "RECEPTORES EP1 E EP3 MODULAM AS CRISES EPILÉPTICAS INDUZIDAS POR PENTILENOTETRAZOL E ÁCIDO CAÍNICO EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/3852.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Epilepsy is one of the most common neurologic disorders. It has been suggested that seizures may be facilitaded by inflammation. PGE2 is one of the most important inflammatory mediators, and facilitates pentylenetetrazol (PTZ)-induced seizures by stimulating EP1 and EP3 receptors. However, up to the present moment, no study has investigated whether EP1 and EP3 receptors blocking attenuate seizures induced by convulsants other than PTZ. It is also unknown whether Na+,K+-ATPase activity alterations are involved in such an effect. The

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3

Ratzlaff, Viviane. "Padronização e validação de um novo modelo de febre induzida pela injeção intratecal de prostaglandina e2 em ratos jovens." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/11148.

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The fever response, besides being part of host defense response to infection or inflammation, is associated with discomfort and anxiety and may constitute a risk for febrile seizures in children. Therefore, antipyretic therapy is routinely prescribed for febrile patients. The animal models of fever using the systemic injection of lipopolysaccharide (LPS) and Baker yeast, described in the literature, are suitable for screening of novel antipyretics, but they do not provide information regarding the mechanism of action of these compounds. Therefore, the present study aimed to describe and valida

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4

Milne, Stuart Angus. "Characterisation of the inhibitory EP-receptors present in human monocytes." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/22496.

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5

Rahal, Sherine S. "The role of prostaglandin EP receptors in a model of glomerulonephritis." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26750.

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Prostaglandin E2 (PGE2) interacts with four E-Prostanoid (EP) receptor subtypes---designated EP1--4 . In glomerulonephritis (GN), a renal inflammatory disease, inhibition of enhanced renal PGE2 synthesis by nonsteroidal-anti-inflammatory drugs (NSAIDs), results in both beneficial anti-proteinuric effects and deleterious side effects on renal blood flow (RBF) and Na+ homeostasis, implying that one or more EP subtypes may mediate these actions. We set out to investigate the role of the EP1 receptor in GN since it localizes to the collecting duct, where it may regulate Na+ homeostasis, in podocyt

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6

Slipetz, Deborah M. "The prostaglandin E₂ EP₄ receptor : the elucidation of agonist mediated receptor regulation and a novel therapeutic role for an EP₄ agonist in allergic lung inflammation." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111868.

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Prostaglandin (PG) E2 is involved in a number of physiological and path op hysiologicaI events in many tissues. PGE2 mediates its actions through interaction with specific plasma-membrane G-protein coupled receptors (GPCR's). There are four subtypes of PGE2 receptors: EP1, EP2, EP3 and EP4, classified by their different pharmacological profiles and signal transduction pathways. EP4 agonists have potential therapeutic benefit in diseases such as osteoporosis (EP4 mediates the bone anabolic actions of PGE 2), but possibly in other areas such as asthma. A characteristic feature of GPCR's is their

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7

Li, Sau Wei. "Pharmacological characterization of human neutrophil prostanoid EP receptors : modulation of neutrophil function." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307121.

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8

Arulkumaran, Shankari. "The roles of prostanoid EP receptors in the control of contractions of human myometrium." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9305.

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The primary function of the uterus during pregnancy is to harbour the growing fetus in a quiescent environment. Upon maturation of the fetus, the uterus generates forceful contractions during labour. Prostaglandins are central in the parturition process. PGE2 in particular, is produced in large quantities by fetal membranes and possible roles include cervical ripening and the stimulation of uterine contractions. PGE2 exhibits a wide spectrum of physiological actions depending on the distribution and subtypes of EP receptors. EP1 and EP3 mediate contractions, but there is no consensus about the

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9

Akram, Asha. "Examining the potential of PGE₂ receptor EP₄ as a neuroprotective target following ischaemic injury." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28245.

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Ischaemic stroke instigates a series of pathological mechanisms which contribute to injury. Despite significant research in this field successful clinical treatment is limited. This highlights the need to identify novel therapeutic targets in order to assess whether clinical investigation is warranted. The enzyme cyclooxygenase-2 (COX-2) is a key contributor to inflammatory injury following stroke. Upregulation of this enzyme results in increased prostanoid synthesis, which mediate many physiological and pathological functions. Prostaglandin E₂ (PGE₂) is a key mediator in inflammation and acti

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10

Katsuyama, Masato. "A Study on the Structure and Function of the Prostaglandin E Receptor Subtype EP[2]." 京都大学 (Kyoto University), 1998. http://hdl.handle.net/2433/73162.

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11

Carvalho, Liliana Sofia Machado de. "Expression of cyclooxygenase enzymes and prostaglandin E2 receptors in inflammatory airway diseases." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6347.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Aspirin-intolerant asthma (AIA) is a syndrome where the interplay between cyclooxygenase (COX) and lipoxygenase (LOX) pathways is evident and is characterized by several abnormalities in the regulation and biosynthesis of eicosanoid mediators and eicosanoid receptors. Several observations indicate the presence of a complex change in the arachidonic acid (AA) metabolism in patients who suffer from AIA. However, previous studies showed some discrepant results when upper and lower airways were analyzed, and there

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12

Neuschäfer-Rube, Frank, DeVries Christa, Kristina Hänecke, Kurt Jungermann та Gerhard Püschel. "Molecular cloning and expression of a prostaglandin E₂ receptor of the EP₃ϐ subtype from rat hepatocytes". Universität Potsdam, 1994. http://opus.kobv.de/ubp/volltexte/2010/4583/.

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Rat hepatocytes have previously been reported to possess prostaglandin E₂ receptors of the EP₃-type (EP₃-receptors) that inhibit glucagonstimulated glycogenolysis by decreasing cAMP. Here, the isolation of a functional EP₃ϐ receptor cDNA clone from a rat hepatocyte cDNA library is reported. This clone can be translated into a 362-amino-acid protein, that displays over 95% homology to the EP₃ϐ receptor from mouse mastocytoma. The amino- and carboxy-terminal region of the protein are least conserved. Transiently transfected HEK 293 cells expressed a single binding site for PGE₂ with an apparent

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13

Hutchinson, Anthony Jason. "The Expression and Function of Native EP and FP Prostanoid Receptors in Cultured Cells Derived from the Human Brain and Eye." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/196126.

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The prostaglandins comprise a group of bioactive lipids generated from arachidonic acid by cyclooxygenases and cell type-specific prostaglandin and thromboxane synthases. Prostaglandins mediate local cell signaling interactions by activation of G-protein coupled prostanoid receptors. Because the prostaglandins and their receptors are active in all tissues, they have an extraordinarily broad spectrum of physiological and pathophysiological functions that have hampered the development of safe prostanoid-based medications. This situation has emphasized the importance of understanding the function

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14

Rastogi, Shruti. "The Role of Prostaglandin E2 in causing susceptibility towards Anaphylaxis." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21632.

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Die Ausbildung und der Schweregrad einer Anaphylaxie kann durch verschiedene Co-Faktoren beeinflusst werden. Zu diesen zählen die nichtsteroidalen Antiphlogistika (NSAIDs), die ihre Wirkung über die Inhibition der COX entfalten. Wie NSAIDs den Schweregrad der Anaphylaxie beeinflussen, ist bisher nicht genau bekannt. Interessanterweise zeigen Anaphylaxie-Patienten mit einer NSAID-Hypersensibilität niedrige Konzentrationen des regulatorischen Prostaglandins E2 (PGE2). Zudem zeigen ASA-tolerante und –intolerante Asthma-Patienten variable anaphylaktische Sensitivitäten. Anhand der vorliegenden A

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15

Wang, Xingya. "The distinct role of cyclooxygenase-2 in prostate and bladder carcinogenesis." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180488733.

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16

Mori, Kiyoshi. "Gene expression of the human prostaglandin E receptor EP[4] subtype : differential regulation in monocytoid and lymphoid lineage cells by phorbol ester." Kyoto University, 1997. http://hdl.handle.net/2433/160737.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第6737号<br>医博第1837号<br>新制||医||656(附属図書館)<br>UT51-97-H121<br>京都大学大学院医学研究科内科系専攻<br>(主査)教授大熊稔, 教授伊藤和彦, 教授中尾一和<br>学位規則第4条第1項該当

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17

Ferguson, Shawn. "Non-steriodal anti-inflammatory drug mediated regulation of COX-2 and EP¦3 receptor expression in the M-1 murine cortical collecting duct cell line." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0029/MQ67814.pdf.

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18

Elander, Louise. "Prostaglandin E2 in Brain-mediated Illness Responses." Doctoral thesis, Linköpings universitet, Cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53701.

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We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. Illness responses are elicited and include inflammation, fever, decreased appetite, lethargy and increased sensitivity to painful stimuli in order to defeat invaders. While many of these signs of disease are controlled by the central nervous system, it has remained an enigma how signals from the peripheral immune system reach the brain through its blood-brain barrier, which precludes macromolecules, includi

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19

"Investigation of mechanisms underlying synergism between prostanoid EP₃ receptor agonists and strong vasoconstrictor agents." 2003. http://library.cuhk.edu.hk/record=b5891614.

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Le Gengyun.<br>Thesis submitted in: December 2002.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 161-182).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Abbreviations --- p.v<br>Acknowledgements --- p.vii<br>Publications --- p.viii<br>Table of Contents --- p.ix<br>Chapter Chapter 1 --- INTRODUCTION --- p.1<br>Chapter 1. --- Vasoconstrictors --- p.1<br>Chapter 1.1 --- An overview of vascular smooth muscle contraction --- p.1<br>Chapter 1.2 --- Strong and weak vasoconstrictors --- p.5<br>Chapter 1.2.1 --- Mechani

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20

Wang, Yen-Chen, and 王彥臻. "Regulation of PGE2 on the Human Dental Pulp Cells : Role of EP Receptors Activation and Their Signaling." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/ebyeg3.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>101<br>Aim: Bacterial infection and mechanical injuries can cause pulp inflammation. Prostanoids production of pulp cells were involved in the inflammatory and healing processes of dental pulp. These contradictory actions of PGE2 further support the presence of diverse PGE2 receptor isoforms in different tissues or cells. However, the significance of EP receptors in human dental pulp has not yet been fully described. The aim of the study is to investigate the role of EP receptors and their signaling in regulation of the dental pulp. Materials and Methods: Primary-cu

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21

"The effects of prostanoid EP₃ receptor agonists and their interactions with other agents on rat vascular preparations." 2003. http://library.cuhk.edu.hk/record=b5891542.

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Hung Hoi Yan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 138-160).<br>Abstracts in English and Chinese.<br>ABSTRACT --- p.i<br>ACKNOWLEDGEMENTS --- p.v<br>PUBLICATIONS BASED ON THE WORK IN THIS THESIS --- p.vi<br>TABLE OF CONTENTS --- p.vii<br>ABBREVIATIONS --- p.ix<br>Chapter CHAPTER 1 --- INTRODUCTION --- p.1<br>Chapter 1.1 --- Prostanoids and vasoconstriction --- p.1<br>Chapter 1.1.1 --- EP3 receptors --- p.2<br>Chapter 1.1.2 --- EP1 receptors --- p.16<br>Chapter 1.1.3 --- FP receptors --- p.23<br>Chapter 1.1.4 --- TP

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22

Hoggatt, Jonathan G. "Eicosanoid Regulation of Hematopoietic Stem and Progenitor Cell Function." Thesis, 2010. http://hdl.handle.net/1805/2206.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Adult hematopoietic stem cells (HSC) are routinely used to reconstitute hematopoiesis after myeloablation; however, transplantation efficacy and multilineage reconstitution can be limited by inadequate HSC number, or poor homing, engraftment or self-renewal. We have demonstrated that mouse and human HSC express prostaglandin E2 (PGE2) receptors, and that short-term ex vivo exposure of HSC to PGE2 enhances their homing, survival and proliferation, resulting in increased long-term repopulating cell and competitive repopulating unit (C

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