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1

McCoy, Claire E., ed. Toll-Like Receptors. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3335-8.

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2

McCoy, Claire E., and Luke A. J. O’Neill, eds. Toll-Like Receptors. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-541-1.

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3

O’Neill, Luke A. J., and Elizabeth Brint, eds. Toll-like Receptors in Inflammation. Birkhäuser Basel, 2005. http://dx.doi.org/10.1007/3-7643-7441-1.

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4

Bauer, Stefan, and Gunther Hartmann, eds. Toll-Like Receptors (TLRs) and Innate Immunity. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-72167-3.

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5

Toll-like receptors: Roles in infection and neuropathology. Springer Verlag, 2009.

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6

Kielian, Tammy, ed. Toll-like Receptors: Roles in Infection and Neuropathology. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00549-7.

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7

Innate DNA and RNA recognition: Methods and protocols. Humana Press, 2014.

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8

Rezaei, Nima, ed. Toll-like Receptors. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.80367.

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9

Toll and Toll-Like Receptors: An Immunologic Perspective. Springer US, 2005. http://dx.doi.org/10.1007/b139083.

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10

Rich, Tina. Toll and Toll-Like Receptors : : An Immunologic Perspective. Springer, 2010.

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11

W, Konat Gregory, ed. Signaling by toll-like receptors. Taylor & Francis Group, 2008.

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12

J, O'Neill Luke A., and Brint Elizabeth, eds. Toll-like receptors in inflammation. Birkhäuser Verlag, 2005.

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13

Prof, Bauer Stefan, Hartmann Gunther 1966-, and Akira S, eds. Toll-like receptors (TLRs) and innate immunity. Springer, 2008.

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14

Prof, Bauer Stefan, Hartmann Gunther 1966-, and Akira S, eds. Toll-like receptors (TLRs) and innate immunity. Springer, 2008.

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15

Toll and Toll-Like Receptors:: An Immunologic Perspective (Molecular Biology Intelligence Unit). Springer, 2005.

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16

M. Greene, Catherine, ed. Toll-Like Receptors in Diseases of the Lung. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/97816080536291120101.

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17

Tolllike Receptors Methods And Protocols. Humana Press, 2009.

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18

Signaling by Toll-Like Receptors (Methods in Signal Transduction Series). CRC, 2008.

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19

(Editor), Bruce Beutler, and Hermann Wagner (Editor), eds. Toll-Like Receptor Familiy Members and Their Ligands. Springer, 2002.

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20

Toll-like receptor family members and their ligands. Springer, 2002.

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21

Nucleic Acid Sensors and Antiviral Immunity. Taylor & Francis Group, 2012.

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22

Geri, Guillaume, and Jean-Paul Mira. Host–pathogen interactions in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0306.

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Infection by a pathogenic micro-organism triggers a coordinated activation of both innate and adaptive immune responses. The innate immune response quickly triggers an antimicrobial response that will initiate development of a pathogen-specific, long-lasting adaptive immune response. Accurate recognition of microbial-associated molecular patterns by pattern-recognition receptors (PRRs) is the cornerstone of this immediate response. Most studied PRRs are Toll-like receptors (TLRs) and their kinase signalling cascades that activate nuclear transcription factors, and induce gene expression and cy
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23

Voll, Reinhard E., and Barbara M. Bröker. Innate vs acquired immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048.

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The innate and the adaptive immune system efficiently cooperate to protect us from infections. The ancient innate immune system, dating back to the first multicellular organisms, utilizes phagocytic cells, soluble antimicrobial peptides, and the complement system for an immediate line of defence against pathogens. Using a limited number of germline-encoded pattern recognition receptors including the Toll-like, RIG-1-like, and NOD-like receptors, the innate immune system recognizes so-called pathogen-associated molecular patterns (PAMPs). PAMPs are specific for groups of related microorganisms
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24

Wiersinga, W. Joost, and Tom van der Poll. The host response to infection in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0303.

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Infection continues to be a leading cause of intensive care unit death. The host response to infection can be seen as a pattern recognition receptor (PRR)-mediated dysregulation of the immune system following pathogen invasion in which a careful balance between inflammatory and anti-inflammatory responses is vital. A measured and rapid response to microbial invasion is essential to health. The same immunological and coagulation systems that protect against localized infection can act to our disadvantage when these systems are activated systemically during generalized microbial infection. Toll-
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