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1

Bivona, Giulia, Bruna Lo Sasso, Luisa Agnello, and Marcello Ciaccio. "FROM THE BLOOD- BRAIN BARRIER TO BEHAVIOR." Acta Neuropsychologica 15, no. 1 (2017): 63–67. http://dx.doi.org/10.5604/12321966.1237451.

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Research in the field of neuropsychoimmunology has enabled the researchers to show that cytokines target the brain to organize a "sickness response," which is fever, activation of hypothalamuspituitary- adrenal axis and behavioural alterations that develop in sick individuals. perypheral cytokines do not act directly on the brain; they trigger the production of cytokines in the brain parenchima itself, with a possible relay at the interface between internal milieeu and the brain, which are endothelial cells and circumven- tricular organs. The affective and behavioural changes that develop duri
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2

Lien, Egil, and Robin R. Ingalls. "Toll-like receptors." Critical Care Medicine 30, Suppl. (2002): S1—S11. http://dx.doi.org/10.1097/00003246-200201001-00001.

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3

Erickson, Benjamin, Kirk Sperber, and William H. Frishman. "Toll-Like Receptors." Cardiology in Review 16, no. 6 (2008): 273–79. http://dx.doi.org/10.1097/crd.0b013e3181709fd8.

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4

Warren, H. Shaw. "Toll-like receptors." Critical Care Medicine 33, Suppl (2005): S457—S459. http://dx.doi.org/10.1097/01.ccm.0000185504.39347.5d.

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5

Muzio, Marta, and Alberto Mantovani. "Toll-like receptors." Microbes and Infection 2, no. 3 (2000): 251–55. http://dx.doi.org/10.1016/s1286-4579(00)00303-8.

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6

Shin, Ho. "Toll-like Receptors." British Journal of Medicine and Medical Research 3, no. 1 (2013): 58–68. http://dx.doi.org/10.9734/bjmmr/2013/2071.

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7

Moresco, Eva Marie Y., Diantha LaVine, and Bruce Beutler. "Toll-like receptors." Current Biology 21, no. 13 (2011): R488—R493. http://dx.doi.org/10.1016/j.cub.2011.05.039.

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8

Kaisho, Tsuneyasu, and Shizuo Akira. "Toll-like receptors as adjuvant receptors." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1589, no. 1 (2002): 1–13. http://dx.doi.org/10.1016/s0167-4889(01)00182-3.

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9

Bilak, H., S. Tauszig-Delamasure, and J. L. Imler. "Toll and Toll-like receptors in Drosophila." Biochemical Society Transactions 31, no. 3 (2003): 648–51. http://dx.doi.org/10.1042/bst0310648.

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The Drosophila Toll receptor controls the immune response to Gram-positive bacteria and fungi by activating a signalling pathway partially conserved throughout evolution. The Drosophila genome encodes eight additional Toll-related receptors, most of which appear to carry out developmental rather than immune functions. One exception may be Toll-9, which shares structural and functional similarities with mammalian TLRs.
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10

Modlin, Robert L. "Mammalian Toll-like receptors." Annals of Allergy, Asthma & Immunology 88, no. 6 (2002): 543–48. http://dx.doi.org/10.1016/s1081-1206(10)61883-2.

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11

Akira, Shizuo. "Mammalian Toll-like receptors." Current Opinion in Immunology 15, no. 1 (2003): 5–11. http://dx.doi.org/10.1016/s0952-7915(02)00013-4.

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12

Akira, Shizuo. "Mammalian Toll-like receptors." Current Opinion in Immunology 15, no. 2 (2003): 238. http://dx.doi.org/10.1016/s0952-7915(03)00005-0.

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13

Read, Robert C., and David H. Wyllie. "Toll receptors and sepsis." Current Opinion in Critical Care 7, no. 5 (2001): 371–75. http://dx.doi.org/10.1097/00075198-200110000-00010.

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14

Blasius, Amanda L., and Bruce Beutler. "Intracellular Toll-like Receptors." Immunity 32, no. 3 (2010): 305–15. http://dx.doi.org/10.1016/j.immuni.2010.03.012.

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15

Brownlie, Robert, and Brenda Allan. "Avian toll-like receptors." Cell and Tissue Research 343, no. 1 (2010): 121–30. http://dx.doi.org/10.1007/s00441-010-1026-0.

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16

Wong, F. Susan, and Li Wen. "Toll-Like Receptors and Diabetes." Annals of the New York Academy of Sciences 1150, no. 1 (2008): 123–32. http://dx.doi.org/10.1196/annals.1447.063.

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17

Finberg, Robert W., and Evelyn A. Kurt-Jones. "Viruses and Toll-like receptors." Microbes and Infection 6, no. 15 (2004): 1356–60. http://dx.doi.org/10.1016/j.micinf.2004.08.013.

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18

Falck-Hansen, Mika, Christina Kassiteridi, and Claudia Monaco. "Toll-Like Receptors in Atherosclerosis." International Journal of Molecular Sciences 14, no. 7 (2013): 14008–23. http://dx.doi.org/10.3390/ijms140714008.

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19

Kim, G. K., and J. Q. Del Rosso. "Toll-like receptors and skin." Yearbook of Dermatology and Dermatologic Surgery 2012 (January 2012): 334–35. http://dx.doi.org/10.1016/j.yder.2012.02.163.

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20

Ermertcan, A. T., F. Öztürk, and K. Gündüz. "Toll-like receptors and skin." Journal of the European Academy of Dermatology and Venereology 25, no. 9 (2011): 997–1006. http://dx.doi.org/10.1111/j.1468-3083.2011.04049.x.

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21

Michie, Colin A. "Triage by Toll-like receptors." Trends in Molecular Medicine 8, no. 1 (2002): 6. http://dx.doi.org/10.1016/s1471-4914(01)02231-6.

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22

Takeda, Kiyoshi, and Shizuo Akira. "Toll receptors and pathogen resistance." Cellular Microbiology 5, no. 3 (2003): 143–53. http://dx.doi.org/10.1046/j.1462-5822.2003.00264.x.

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23

Miller, Lloyd S. "Toll-Like Receptors in Skin." Advances in Dermatology 24 (November 2008): 71–87. http://dx.doi.org/10.1016/j.yadr.2008.09.004.

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24

Singh, Madhu V., and François M. Abboud. "Toll-like receptors and hypertension." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307, no. 5 (2014): R501—R504. http://dx.doi.org/10.1152/ajpregu.00194.2014.

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Hypertension and associated inflammatory processes that accelerate cardiovascular damage are regulated by the innate immune system. Toll-like receptors (TLR) are major components of the innate immune system that recognize endogenous damage-associated molecular patterns to activate prominent inflammatory signaling including activation of nuclear factor-κB (NF-κB). However, the role of TLR in the etiology of hypertension is not well understood. TLR signaling is dependent on adaptor proteins that, along with the TLR expression patterns, confer specificity of the inflammatory response and its path
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25

Henneke, Philipp, and Douglas T. Golenbock. "TIRAP: how Toll receptors fraternize." Nature Immunology 2, no. 9 (2001): 828–30. http://dx.doi.org/10.1038/ni0901-828.

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26

Rassa, John C., and Susan R. Ross. "Viruses and Toll-like receptors." Microbes and Infection 5, no. 11 (2003): 961–68. http://dx.doi.org/10.1016/s1286-4579(03)00193-x.

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27

Imler, Jean-Luc, and Jules A. Hoffmann. "Toll receptors in innate immunity." Trends in Cell Biology 11, no. 7 (2001): 304–11. http://dx.doi.org/10.1016/s0962-8924(01)02004-9.

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28

Petry, Vanessa, and Anthony A. Gaspari. "Toll-like receptors and dermatology." International Journal of Dermatology 48, no. 6 (2009): 558–70. http://dx.doi.org/10.1111/j.1365-4632.2009.04111.x.

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29

Rakoff-Nahoum, Seth, and Ruslan Medzhitov. "Toll-like receptors and cancer." Nature Reviews Cancer 9, no. 1 (2008): 57–63. http://dx.doi.org/10.1038/nrc2541.

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30

Espevik, T. "TRAFFICKING OF TOLL-LIKE RECEPTORS." Shock 21, Supplement (2004): 10. http://dx.doi.org/10.1097/00024382-200403001-00038.

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31

O'mahony, C., and N. Steedman. "Toll-like receptors: that's weird!" International Journal of STD & AIDS 21, no. 6 (2010): 450. http://dx.doi.org/10.1258/ijsa.2010.010184.

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32

Finberg, Robert W., Jennifer P. Wang, and Evelyn A. Kurt-Jones. "Toll like receptors and viruses." Reviews in Medical Virology 17, no. 1 (2006): 35–43. http://dx.doi.org/10.1002/rmv.525.

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33

Bernard, Marina, and Rosario Rizzuto. "Toll‐like receptors hit calcium." EMBO reports 15, no. 5 (2014): 468–69. http://dx.doi.org/10.1002/embr.201438685.

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34

Goodsell, David S. "Recognition highlights: Toll-like receptors." Journal of Molecular Recognition 19, no. 5 (2006): 387–88. http://dx.doi.org/10.1002/jmr.778.

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35

Koga, Kaori, and Gil Mor. "Toll-like Receptors and Pregnancy." Reproductive Sciences 14, no. 4 (2007): 297–99. http://dx.doi.org/10.1177/1933719107304562.

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36

Fischer, Maria, and Marc Ehlers. "Toll-like Receptors in Autoimmunity." Annals of the New York Academy of Sciences 1143, no. 1 (2008): 21–34. http://dx.doi.org/10.1196/annals.1443.012.

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37

Delgado, Mónica A., Rasha A. Elmaoued, Alexander S. Davis, George Kyei, and Vojo Deretic. "Toll-like receptors control autophagy." EMBO Journal 27, no. 7 (2008): 1110–21. http://dx.doi.org/10.1038/emboj.2008.31.

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38

O'Neill, L. A. J. "Toll-like receptors in cancer." Oncogene 27, no. 2 (2008): 158–60. http://dx.doi.org/10.1038/sj.onc.1210903.

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39

Hansbro, Philip M., Tatt Jhong Haw, Malcolm R. Starkey, and Kensuke Miyake. "Toll-like receptors in COPD." European Respiratory Journal 49, no. 5 (2017): 1700739. http://dx.doi.org/10.1183/13993003.00739-2017.

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40

Tuon, Felipe F., Valdir S. Amato, Hélio A. Bacha, Tariq AlMusawi, Maria I. Duarte, and Vicente Amato Neto. "Toll-Like Receptors and Leishmaniasis." Infection and Immunity 76, no. 3 (2007): 866–72. http://dx.doi.org/10.1128/iai.01090-07.

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41

Bell, Jennifer. "Living without Toll-like receptors." Nature Reviews Immunology 3, no. 4 (2003): 261. http://dx.doi.org/10.1038/nri1073.

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42

Grote, Karsten, Harald Schütt, and Bernhard Schieffer. "Toll-Like Receptors in Angiogenesis." Scientific World JOURNAL 11 (2011): 981–91. http://dx.doi.org/10.1100/tsw.2011.92.

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Toll-like receptors (TLRs) are known as pattern-recognition receptors related to the Toll protein ofDrosophila. After recognition of pathogen-associated molecular patterns of microbial origin, the TLRs alert the immune system, and initiate innate and adaptive immune responses. The TLR system, though, is not confined solely to the leukocyte-mediated immune defense against exogenous pathogens. Besides myeloid cells, TLR expression has been reported in multiple tissues and cell types, including epithelial and endothelial cells. Moreover, despite the microbial patterns that are commonly accepted a
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43

Tobias, P. S., and L. K. Curtiss. "Toll-like receptors in atherosclerosis." Biochemical Society Transactions 35, no. 6 (2007): 1453–55. http://dx.doi.org/10.1042/bst0351453.

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At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity. Identifying the initiators and mediators of that inflammation can provide promising avenues for prevention or therapy. Two prominent risk factors, hyperlipidaemia and infectious disease, point to innate immune mechanisms as potential contributors to proatherogenic inflammation. The TLRs (Toll-like
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44

Hurst, Julia, and Philipp von Landenberg. "Toll-like receptors and autoimmunity." Autoimmunity Reviews 7, no. 3 (2008): 204–8. http://dx.doi.org/10.1016/j.autrev.2007.11.006.

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45

Mempel, Martin, Behnam Naderi Kalali, Markus Ollert, and Johannes Ring. "Toll-Like Receptors in Dermatology." Dermatologic Clinics 25, no. 4 (2007): 531–40. http://dx.doi.org/10.1016/j.det.2007.06.014.

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46

Fiset, Pierre Olivier, Meri Katarina Tulic, and Qutayba Hamid. "Toll-like receptors and atopy." Journal of Allergy and Clinical Immunology 116, no. 2 (2005): 467–70. http://dx.doi.org/10.1016/j.jaci.2005.04.034.

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47

Okun, Eitan, Kathleen J. Griffioen, Justin D. Lathia, Sung-Chun Tang, Mark P. Mattson, and Thiruma V. Arumugam. "Toll-like receptors in neurodegeneration." Brain Research Reviews 59, no. 2 (2009): 278–92. http://dx.doi.org/10.1016/j.brainresrev.2008.09.001.

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48

Iribarren, Pablo, and Ji Ming Wang. "Toll-like receptors and diseases." International Immunopharmacology 11, no. 10 (2011): 1389–90. http://dx.doi.org/10.1016/j.intimp.2011.08.010.

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49

Ishii, Ken J., and Shizuo Akira. "Toll-like receptors and sepsis." Current Infectious Disease Reports 6, no. 5 (2004): 361–66. http://dx.doi.org/10.1007/s11908-004-0034-1.

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50

Chtarbanova, Stanislava, and Jean-Luc Imler. "Microbial Sensing by Toll Receptors." Arteriosclerosis, Thrombosis, and Vascular Biology 31, no. 8 (2011): 1734–38. http://dx.doi.org/10.1161/atvbaha.108.179523.

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