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Dissertations / Theses on the topic 'Recombinant human antibodies'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Davidson, Lisa. "Humanised recombinant antibodies for human cancer therapy." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501643.

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Humanisation of rodent mAbs by CDR-grafting is now a standard procedure for reducing immunogenicity and recruiting human effector functions with ten humanised mAbs approved for use and many more in development. This project aimed to develop two anti-cancer therapeutics aimed at exploiting two tumour associated antigens overexpressed in the tumour environment.

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2

Johansson, Daniel X. "Expression and interaction studies of recombinant human monoclonal antibodies /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-137-1/.

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3

Fiddes, Jane L. Sutton Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Development of recombinant human monoclonal antibodies suitable for blood grouping using antibody engineering techniques." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2007. http://handle.unsw.edu.au/1959.4/40503.

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Transfusion medicine is an important part of modern health care and the provision of reliably phenotyped red blood cells (RBC) is essential for safe and effective blood transfusions. For identification of many RBC antigens, monoclonal antibodies of either murine or human origin are available for use in agglutination assays, in which they perform as well as or better than the human polyclonal antibody preparations which they have replaced. However, the detection of some blood groups is still reliant on the use of human polyclonal antisera, which is a less reliable reagent source with respect to

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4

Fuchs, Manon [Verfasser], and Stefan [Akademischer Betreuer] Dübel. "Human recombinant antibodies against Mycobacterium tuberculosis antigens / Manon Fuchs ; Betreuer: Stefan Dübel." Braunschweig : Technische Universität Braunschweig, 2014. http://d-nb.info/117582156X/34.

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5

Basu, B. J. "Development of human recombinant MT1-MMP antibodies for the diagnosis and treatment of cancer." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596458.

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MT1-MMP domains were expressed and purified as Calmodulin (CaM)-tagged recombinant proteins to serve as targets for identification of specific antibodies. V(ariable) domain phage display techniques were employed to isolate single chain V domain antibody fragments (scFvs) against MT1-MMP hemopexin domain from a naïve human V gene library. Following 3 rounds of phage selection using solid phase panning, unique antibody clones were identified that are specific for MT1-MMP and do not react with soluble MMPs. Sequencing of the V genes and epitope mapping studies by surface plasmon resonance identif

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6

Andersson, Eva. "Studies of T- and B-cells for the generation of human antigen specific antibodies." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945125.html.

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7

Marques, Fabiana Carvalho. "Development of specific recombinant single-domain antibodies against gp120 HIV-1 glycoprotein and their selection by Phage Display." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16334.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections to succeed. One of the most important factors in the worldwide spread of HIV is its enormous genetic variability and rapid evolution. The revealing of all stages of HIV replication cycle led to the identification of potential therapeutic targets in order to decrease the replicative process. However, the acquisition and tra

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8

Raffai, Robert Leslie. "Immunochemical study of human apolipoprotein E: Development of LDL-receptor mimetic monoclonal antibodies, using recombinant DNA approaches." Thesis, University of Ottawa (Canada), 1998. http://hdl.handle.net/10393/4422.

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Apolipoprotein (apo)E is a 299 amino acid polypeptide that plays an important role in plasma lipoprotein metabolism. A major physiological function of apoE resides in its ability to be specifically recognized by cellular low-density-lipoprotein receptors (LDLr). A common apoE isoform is defective in its binding to the LDLr and its inheritance can lead to hyperlipidemia. In addition to apoE genetic polymorphism, apoE interaction with the LDLr also depends on apoE conformation. While lipid-free apoE cannot interact with the LDLr, upon binding to lipid, apoE undergoes a conformational change that

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9

Raffaï, Robert L. "Immunochemical study of human apolipoprotein E, development of LDL-receptor mimetic monoclonal antibodies, using recombinant DNA approaches." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ28369.pdf.

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10

Kenyon, Andrew Robert. "The directed selection of recombinant human anti-testosterone antibodies and their use in immuno-modulating androgen receptor function." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493587.

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Prostate cancer (PCa) is the second most common cancer in Western men; with over 30,000 new cases are diagnosed in the UK each year. Primarily treatment involves targeting the androgen-signalling pathway by blocking production of testicular androgens and/or inhibiting AR function. Current treatments depend on the age and health of the patient. These treatments range from a watch and wait strategy to androgen ablation therapy, by chemical or surgical castration, with the addition of using anti-androgens to block the AR function. The drawbacks of these treatments include loss of bone mineral den

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11

Wenzel, Esther Veronika Verfasser], Michael [Akademischer Betreuer] [Hust, and Stefan [Akademischer Betreuer] Dübel. "Development of recombinant human anti-diphtheria toxin neutralizing antibodies for diphtheria therapy / Esther Veronika Wenzel ; Michael Hust, Stefan Dübel." Braunschweig : Technische Universität Braunschweig, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:084-2019050215003.

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12

Zahid, Muhammad. "Design and Optimization of Recombinant Antibodies Directed Against Platelet Glycoprotein VI with Therapeutic and Diagnostic Potentials." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00922980.

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Human platelets glycoprotein VI (GPVI) is evidenced to be a platelet receptor of major importance in the occurrence of arterial thrombosis. Thus, it can be considered to be of great interest in diagnosis and therapeutic of atheriosclerotic diseases. Antibodies are powerful molecules which can be used in both diagnostic as well as for therapeutic purposes due to their unique characteristics. Monoclonal and recombinant antibodies have antigen restricted specificity, high affinity and can be used in various assays. Moreover, the good knowledge of their structure and molecular engineering faciliti

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13

Gärdefors, Katarina. "Development and characterization of Mantle Cell Lymphoma specific IgGs." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15255.

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<p>Mantle cell lymphoma (MCL) is one of several sub-types of B-cell lymphomas. The malignancy is very aggressive and average survival time is short. The hallmark of MCL is over expression of cyclin D1, however about 15% of all MCL cases do not display this over expression and are easily misdiagnosed. Recently the transcription factor Sox11 has been shown to be specifically over expressed in the nucleus of MCL-tumour cells, and polyclonal rabbit anti-Sox11 antibodies have been used to successfully identify MCL in both cyclin D1 positive and negative cases. Howev-er, human recombinant MCL-specif

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14

Ahsendorf, Henrike Verfasser], Bertram [Akademischer Betreuer] [Brenig, Bertram [Gutachter] Brenig, Christiane [Gutachter] Stahl-Hennig, and El Wahed Ahmed [Gutachter] Abd. "Selection and characterization of human recombinant antibodies against Orthopoxviruses from an immunoglobulin library and mapping of functional epitopes of Vaccinia virus surface proteins / Henrike Ahsendorf ; Gutachter: Bertram Brenig, Christiane Stahl-Hennig, Ahmed Abd El Wahed ; Betreuer: Bertram Brenig." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1208221833/34.

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15

Ahsendorf, Henrike [Verfasser], Bertram [Akademischer Betreuer] Brenig, Bertram [Gutachter] Brenig, Christiane [Gutachter] Stahl-Hennig, and El Wahed Ahmed [Gutachter] Abd. "Selection and characterization of human recombinant antibodies against Orthopoxviruses from an immunoglobulin library and mapping of functional epitopes of Vaccinia virus surface proteins / Henrike Ahsendorf ; Gutachter: Bertram Brenig, Christiane Stahl-Hennig, Ahmed Abd El Wahed ; Betreuer: Bertram Brenig." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1208221833/34.

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16

Van, Vuren Petrus Jansen. "Development of a recombinant antigen for the detection of antibodies against Rift Valley fever virus in humans and animals / Petrus Jansen van Vuren." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1268.

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Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa that presents a significant health threat to both humans and animals. Outbreaks have serious economical implications. Two facts cause concern. Firstly, recent outbreaks in the Arabian Peninsula and effects of global warming have the implication that the virus might spread further into non-endemic RVF regions since it utilizes a wide range of mosquito vetors. Secondly, RVFV is a potential bio-terrorism agent. Therefore, quick, safe, robust and cost-effective methods of detection and appropriate diagnostic reagents ar

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17

Oliveira, Carina Cantelli Pacheco de. "Metodologias iniciais para implementação de um ELISA para detecção do interferon beta humano recombinante (1A) com aplicação no controle de qualidade de Bio-Manguinhos." Instituto de Tecnologia em Imunobiológicos, 2009. https://www.arca.fiocruz.br/handle/icict/5842.

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Submitted by Priscila Nascimento (pnascimento@icict.fiocruz.br) on 2012-11-21T11:40:46Z No. of bitstreams: 1 carina-cantelli-pacheco-de-oliveira.pdf: 4119562 bytes, checksum: e15daef4939ba93f9357a8bbf218d494 (MD5)<br>Made available in DSpace on 2012-11-21T11:40:46Z (GMT). No. of bitstreams: 1 carina-cantelli-pacheco-de-oliveira.pdf: 4119562 bytes, checksum: e15daef4939ba93f9357a8bbf218d494 (MD5) Previous issue date: 2009<br>Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Bra

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18

Maxwell, P., F. Melendez-Rodriguez, K. B. Matchett, et al. "Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation." 2014. http://hdl.handle.net/10454/8404.

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Yes<br>Recombinant human erythropoietin (rHuEPO) is an effective treatment for anaemia but concerns that it causes disease progression in cancer patients by activation of EPO receptors (EPOR) in tumour tissue have been contro- versial and have restricted its clinical use. Initial clinical studies were flawed because they used polyclonal antibodies, later shown to lack specificity for EPOR. Moreover, multiple isoforms of EPOR caused by differential splicing have been reported in cancer cell lines at the mRNA level but investigations of these variants and their potential impact on tumour pro

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19

Hsu, Hsien-Yun, and 徐先雲. "Production and Characterization of Monoclonal Antibodies Specific to Recombinant Human Indoleamine 2,3-Dioxygenase (rhIDO) protein." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/83006971525335592260.

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碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>98<br>The enzyme indoleamine 2,3-dioxygenase (IDO) attracted scientist special attention by it’s ability to contribute tumors escape from the host’s immune response against them. IDO starves T cells from tryptophan by this important amino acid catabolizing to N-formyl-kynurenine, which makes these T cells unable to mounting appropriate immune responses against tumors. IDO-dependent T cell suppression by dendritic cells due to tryptophan catabolism have effects on T cell proliferation, differentiation, effector functions, and viability. IDO helps suppression of T

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20

Chen, Tzu-Hou, and 陳姿后. "Development of an ELISA for Detection of Human Metapneumovirus Antibodies Based on a Recombinant Nucleocapsid Protein." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/72406993846698429413.

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碩士<br>長庚大學<br>醫學生物技術研究所<br>95<br>Human metapneumovirus (hMPV) is a newly identified virus. It causes severe respiratory disease in children and elderly people. To study the seroprevalence of hMPV in Taiwan, we develops the indirect immuno-fluorescence assays based on nucleocapsid (N) recombinant protein for detection of hMPV IgG antibody in human sera. A total of 1120 human sera from health people, including 516 male and 604 female, were examined by ELISA system based on N recombinant protein. The data show that the positive rate of each age group in Taiwan was 5.3％(5/94) (0-0.6 years), 5.3％(5

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21

Ahsendorf, Henrike. "Selection and characterization of human recombinant antibodies against Orthopoxviruses from an immunoglobulin library and mapping of functional epitopes of Vaccinia virus surface proteins." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-137B-C.

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22

Lipes, BD, YH Chen, H. Ma, HF Staats, DJ Kenan, and MD Gunn. "An entirely cell-based system to generate single-chain antibodies against cell surface receptors." Thesis, 2008. http://hdl.handle.net/10161/903.

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The generation of recombinant antibodies (Abs) using phage display is a proven method to obtain a large variety of Abs that bind with high affinity to a given antigen. Traditionally, the generation of single-chain Abs depends on the use of recombinant proteins in several stages of the procedure. This can be a problem, especially in the case of cell-surface receptors, because Abs generated and selected against recombinant proteins may not bind the same protein expressed on a cell surface in its native form and because the expression of some receptors as recombinant proteins is problematic. To o

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