Relevant bibliographies by topics / Regenerative Agent / Dissertations / Theses
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Dissertations / Theses on the topic 'Regenerative Agent'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Sensfuß, Frank. "Assessment of the impact of renewable electricity generation on the German electricity sector : an agent-based simulation approach /." Düsseldorf : VDI-Verl, 2008. http://www.gbv.de/dms/zbw/561555680.pdf.

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2

Kritzinger, Jacob Johannes. "The game of diminishing returns : Architecture as a regenerative agent of man and nature." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/63622.

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Mining related activities are more expansive than ever before, with population growth data showing an exponential increase. These societies form part of the world consumer market in which people are constantly buying products with a short life-expectancy, such as consumer electronic devices. More often than not, these mining activities occur in developing countries or rural areas. A repercussion of mines located long distances from active communities is the formation of new communities based solely on the monetary system of a mine. Various precedents show the societal damage caused by the
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3

Kristensson, Mikaela, and Sandra Pettersson. "Moving Beyond Sustainability : Change Agents Perceptions on a Regenerative Transition." Thesis, Jönköping University, JIBS Entrepreneurship Centre, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52869.

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Background: Climate change has become the most pressing challenge of our time. Current business approaches to sustainability are instrumental that may portray sustainability as a source of corporate profit rather than acting for change beyond mitigation and adaptation. A regenerative approach to sustainability challenges current practices and aims to create and strengthen environmental and social well-being. Purpose: The purpose of this study is to deepen the understanding of how change agents can be a part of a regenerative sustainability transition. This is done by investigating the attitude
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4

Jordan, René Janelle. "Agent-based modelling of housing choice in the EASEL regeneration district." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/2023/.

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Housing choice behaviour is made up of a wide array of dynamic individual level behaviour which can be recreated and explored using agent-based modelling (ABM). In the UK, there has been a renewed focus on urban regeneration policies over the past decade by the national government. Such policies seek to deal with the problems of deprivation in communities segregated by socioeconomic status. Using the case study district of East and South Easel Leeds (EASEL), an area known to have pockets of disadvantaged communities, the impacts of regeneration policy will be explored. A computer simulation of
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5

SIMONELLI, Anna. "Simplified surgical procedures and bioactive agents in the regenerative treatment of periodontal intraosseous defects." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403405.

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Introduzione La malattia parodontale è caratterizzata dalla distruzione, prevalentemente a carattere infiammatorio, dei tessuti di supporto del dente: cemento radicolare, legamento parodontale e osso alveolare. Proporzionalmente alla modalità di propagazione in senso apicale della lesione placca correlata, la distruzione ossea può esitare in difetti di tipo orizzontale o verticale. I difetti ossei verticali (o difetti intraossei) sono correlati ad un maggior rischio di progressione della malattia parodontale e, quindi, di perdita dentaria. La presenza di un difetto intraosseo associato a profo
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6

Höhme, Stefan. "Agent-based modeling of growing cell populations and the regenerating liver based on image processing." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-39562.

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In the presented thesis we elaborated a general agent based model for multicellular populations. We used this model to shed light on the processes that determine the growth of avascular tumor spheroids and studied the key mechanisms of liver regeneration. In order to make such analyses possible, we developed a comprehensive software tool that allowed us to effectively simulate, visualize and analyze the constructed computational model. We started with a minimal model for two-dimensional monolayers which are a common experimental technique for in vitro cell cultures. We successively advanced ou
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7

Altinel, Ertan. "Manganese(iii) Acetate Mediated Regeneration Of Carbonyl Compounds From Oximes." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607333/index.pdf.

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A facile method for the direct conversion of oximes into carbonyl compounds by treatment with manganese triacetate is described. Manganese triacetate can be used for an effective and mild oxidizing agent for the regeneration of carbonyl compounds in good yield. Many functional groups are tolerated under reaction conditions.
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8

Dorazilová, Jana. "Nové Antibakteriální kolagenové nosiče pro regenerativní medicínu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-438893.

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Tato diplomová práce se zabývá charakterizací 3D porézních kolagenových pěn obsahující vybraná antibakteriální činidla. V literární části jsou shrnuty dosavadní poznatky o biomateriálech a biopolymerech se zaměřením na kolagen a chitosan. Dále jsou v ní popsány antibakteriálních vlastnosti nanočástic v kontextu s využitím selenových nanočástic jako antibakteriální činidla. Pro potřeby této práce byla vybrána antibakteriální aditiva dvojího typu – biopolymerní chitosan a selenové nanočástice. 3D porézní struktury bylo dosaženo metodou lyofilizace. Mechanické vlastnosti biopolymerní matrice byly
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9

Palm, Kristina. "Det riskabla engagemanget : Om regenerativ utveckling av mänskliga resurser, eldsjälar och ledarskap i radikal utveckling." Doctoral thesis, KTH, Industriell arbetsvetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4662.

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This thesis concentrates on the consequences of strong commitment⁄ Engagement in contemporary work. The aim of the thesis is to Build knowledge on regeneration and development of human resources. The empirical research consists of three case studies mainly Based on interviews: two are explorative studies on four strongly Committed champions within two projects of radical reorganisation. The third Empirical study is exploring one strongly engaged champion within an extensive Business rationalisation. The two first case studies were originally set for Other research and are therefore analyzed se
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10

Sadaghiani, Leili. "The effect of dentine conditioning agents on solubilisation of bioactive dentine matrix components and dentine regeneration." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/79592/.

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The dentine-pulp complex is a unique, dynamic organ capable of responding to mild and aggressive injurious stimuli. Deep caries or tooth fractures that extend close to the pulp can lead to inflammation and ultimate pulpal necrosis if not managed appropriately. Current therapeutic regimes for such scenarios include the use of vital pulp (capping) treatments, which attempt to stimulate the pulp’s auto-repair capacity which is still poorly understood and consequently not exploited to its full potential. Amongst the possible mechanisms involved in inducing a dentinogenic response in vital pulp the
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11

Kim, Yanghee. "Hydrogel Preparation for Dual Release of Cell Recruitment Agents and Growth Factors to Aim at Tissue Regeneration." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215572.

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12

Bednarczuk, Lukasz. "Ni-based catalysts for H2 production from ethanol steam reforming: Effect of the support and use of CO2 as regenerating agent and reactant." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/400828.

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In this work, the effect of CO2 on the hydrogen production under substoichiometric ethanol steam reforming (ESR) conditions over nickel based catalysts was studied. A special emphasis was focused on the application of carbon dioxide as a reactant under the CO2-assisted substoichiometric ethanol steam reforming. Moreover, CO2 was applied as regenerating agent to reduce the amount of carbonaceous deposits, which formation is a main drawback of the nickel catalysts. The obtained results were related with the physical-chemical properties of the catalysts. A series of nickel catalysts supported
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13

Braun, Alexandra Carolin [Verfasser], and Lorenz [Gutachter] Meinel. "Bioresponsive delivery of anticatabolic and anabolic agents for muscle regeneration using bioinspired strategies / Alexandra Carolin Braun ; Gutachter: Lorenz Meinel." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1169048048/34.

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14

Rouet, Vincent. "Étude des interactions du VEGF (Vascular Endothelial Growth Factor) et de biomimétiques des héparanes sulfates, les RGTA (ReGeneraTing Agents)." Paris 12, 2004. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990002147210204611&vid=upec.

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L'angiogenèse est un processus dynamique par lequel de nouveaux vaisseaux capillaires sanguins se forment. Ce phénomène est dépendant à la fois (les facteurs (le croissance, comme le VEGF (Vascular Endothelial growth Factor) et des composants de la matrice extracellulaire tels que les héparanes sulfates (HS). Les RGTA (ReGeneraTing Agents) sont des mimétiques (les HIS qui agissent in vivo en stimulant la vitesse et la qualité des processus cicatriciels et en particulier la phase d'angiogenèse. Ce travail a permis d'établir que les RGTA, biopolymères mimant sur le plan fonctionnel les HS et don
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15

Rouet, Vincent Caruelle Jean-Pierre. "Étude des interactions du VEGF (Vascular Endothelial Growth Factor) et de biomimétiques des héparanes sulfates, les RGTA (ReGeneraTing Agents)." Créteil : Université de Paris-Val-de-Marne, 2004. http://doxa.scd.univ-paris12.fr:80/theses/th0214721.pdf.

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16

Subramanian, Bhargavi. "Exploring Neoteric Solvent Extractants: Applications in the Removal of Sorbates From Solid Surfaces and Regeneration of Automotive Catalytic Converters." Cincinnati, Ohio University of Cincinnati, 2007. http://www.ohiolink.edu/etd/view.cgi?ucin1178075024.

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Thesis (M.S.)--University of Cincinnati, 2007.<br>Title from electronic thesis title page (viewed July 12, 2007). Includes abstract. Keywords: Solvent extraction; Soils; Pentachlorophenol; Automobile catalytic converters; Metal chelating agents Includes bibliographical references.
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17

Ribeiro, Fernanda Vieira. "Efeito do meloxicam sobre o reparo osseo ao redor de implantes de titanio." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287909.

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Orientadores: Marcio Zaffalon Casati, Francisco Humberto Nociti Junior<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-08T10:03:39Z (GMT). No. of bitstreams: 1 Ribeiro_FernandaVieira_M.pdf: 6226415 bytes, checksum: b38d7ee0ba1cf539da8c71788c69fbad (MD5) Previous issue date: 2007<br>Resumo: O objetivo deste estudo foi avaliar a influência de um antiinflamatório não esteroidal inibidor seletivo de COX-2, meloxicam, sobre o reparo ósseo ao redor de implantes de titânio colocados em tíbias de ratos. Fo
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18

CAPRIOLI, CATERINA. "Agent-based model and Geographic Information System (GIS): an integrated approach to test sustainable policies and urban transformation scenarios." Doctoral thesis, Politecnico di Torino, 2022. http://hdl.handle.net/11583/2964778.

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19

Goode, Christopher T. "The development and recovery of vestibular reflexes in the domestic chicken /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/10632.

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20

Frescaline, Guilhem. "Potentialisation des propriétés de cellules souches mésenchymateuses par des mimétiques de glycosaminoglycannes et leur application en thérapie osseuse en association à des biomatériaux." Thesis, Paris Est, 2010. http://www.theses.fr/2010PEST0041.

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Résumé français manquant<br>Scientific background: GAGs mimetics properties on regenerative process.Glycosaminoglycans (GAGs) are sulfated polysaccharides actually considered as major structural components of the extracellular matrix as well as regulators of cells functions during homeostatic and pathological processes. These GAGs activities are based on their ability to interact with heparin binding growth-factors (HBGF), chemokines and enzymes, to protect them from proteolytic degradation and to potentialyze their interaction with cell surface specific receptors and/or other components of th
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21

Ferrand, Alice. "Développement de biomatériaux nanofibreux/microporeux actifs pour la régénération osseuse." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAE030.

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Les nanotechnologies sont en train de révolutionner le domaine biomédical et plus particulièrement l’ingénierie tissulaire. Elles permettent aujourd’hui, non seulement de réparer mais aussi de régénérer les tissus. Cette nanomédecine régénérative est particulièrement adaptée pour répondre aux besoins importants liés aux maladies dégénératives, au vieillissement et aux traumatismes.Mon travail de thèse s’inscrit dans ce contexte et concerne l’élaboration de biomatériaux nanofibreux et microporeux actifs pour la régénération osseuse. Notre objectif essentiel est de réaliser un implant biodégrada
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22

Hayer, Benoît d'. "Étude des propriétés physiques et mécaniques de microsphères d'alginate au cours d'un cycle de congélation-décongélation et application pour la cryoconservation de cellules souches mésenchymateuses encapsulées." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB015.

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La thérapie cellulaire et les médicaments de thérapie innovante sont des solutions prometteuses pour la régénération des tissus ou organes présentant des défauts fonctionnels ou organiques. Avant le stade de l'insuffisance cardiaque terminale (stade IV NYHA) suite à un infarctus du myocarde, l'implantation d'un patch de fibrine cellularisé avec des progéniteurs myocardiques sur le site de nécrose de l'infarctus, est l'une des perspectives qui permettrait de régénérer un muscle cardiaque fonctionnel et apparait comme étant une alternative nouvelle avec notamment un essai clinique de phase I en
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23

MALGARINI-CLOG, ELISABETH. "Culture in vitro de la vigne. Mise au point de techniques nouvelles de regeneration. Culture de protoplastes et contribution a la mise au point d'un protocole d'infection de protoplastes par les arn viraux du grapevine fanleaf virus, agent du court-noue de la vigne." Strasbourg 1, 1992. http://www.theses.fr/1992STR13135.

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La vigne, plante ligneuse perenne, est sensible a de nombreux pathogenes et notamment aux virus. Deux nepovirus, le gf1v (grapevine fanleaf virus) et l'armv (arabis mosaic virus) sont responsables en france et dans de nombreux pays de la maladie du court-noue de la vigne. L'etude moleculaire d'une souche particuliere, gf1v f13, a permis de positionner les differents genes impliques dans la replication virale. L'introduction de genes viraux dans le genome des plantes est un moyen de lutte efficace contre l'infection virale chez de nombreuses especes. Avant d'aborder de tels programmes, il est n
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24

Friedrich, Benjamin M. "Nonlinear dynamics and fluctuations in biological systems." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-234307.

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The present habilitation thesis in theoretical biological physics addresses two central dynamical processes in cells and organisms: (i) active motility and motility control and (ii) self-organized pattern formation. The unifying theme is the nonlinear dynamics of biological function and its robustness in the presence of strong fluctuations, structural variations, and external perturbations. We theoretically investigate motility control at the cellular scale, using cilia and flagella as ideal model system. Cilia and flagella are highly conserved slender cell appendages that exhibit spontaneous
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Boucugnani, David Agustin. "REGEN Agent a modular and generalized forest regeneration agent /." 2005. http://purl.galileo.usg.edu/uga%5Fetd/boucugnani%5Fdavid%5Fa%5F200508%5Fms.

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Thesis (M.S.)--University of Georgia, 2005.<br>Directed by Donald Nute. For abstract see http://getd.galib.uga.edu/public/boucugnani_david_a_200508_ms/boucugnani_david_a_200508_ms.pdf. Includes bibliographical references (leaves 40-42).
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Bichara, Jean Bashir. "Regenerative therapy for osseous defects with and without NSAIDS." 1997. http://catalog.hathitrust.org/api/volumes/oclc/48208831.html.

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27

Höhme, Stefan. "Agent-based modeling of growing cell populations and the regenerating liver based on image processing." Doctoral thesis, 2009. https://ul.qucosa.de/id/qucosa%3A11043.

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In the presented thesis we elaborated a general agent based model for multicellular populations. We used this model to shed light on the processes that determine the growth of avascular tumor spheroids and studied the key mechanisms of liver regeneration. In order to make such analyses possible, we developed a comprehensive software tool that allowed us to effectively simulate, visualize and analyze the constructed computational model. We started with a minimal model for two-dimensional monolayers which are a common experimental technique for in vitro cell cultures. We successively advanced ou
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28

Braun, Alexandra Carolin. "Bioresponsive delivery of anticatabolic and anabolic agents for muscle regeneration using bioinspired strategies." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-169047.

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Progressive loss of skeletal muscle mass, strength and function poses a major threat to independence and quality of life, particularly in the elderly. To date, sarcopenia therapy consists of resistance exercise training in combination with protein supplementation due to the limited efficacy of available pharmacological options in counteracting the effects of muscle wasting. Therapeutic intervention with growth factors including insulin-like growth factor I (IGF-I) or inhibitors of myostatin  a potent suppressor of myogenesis  hold potential to rebalance the altered activity of anabolic and c
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29

Troxel, Alex. "The antibacterial effect of new intracanal medicaments against established mutlispecies biofilm." Thesis, 2017. https://doi.org/10.7912/C2CM02.

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We investigated the antibacterial effect of low concentrations of double antibiotic paste (DAP) loaded into a methylcellulose system against bacterial biofilms obtained from mature and immature teeth with necrotic pulps. Standardized radicular dentin specimens were randomly divided into six experimental groups (n = 20). Group 1: 5mg/mL DAP treatment. Group 2: 1mg/mL DAP treatment. Group 3: Calcium hydroxide (Ca(OH)2) treatment. Group 4: Methylcellulose. Group 5: No treatment. Group 6: No bacteria or treatment. Clinical bacterial isolates were obtained from mature and immature teeth with
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"Novel Exogenous Agents for Improving Articular Cartilage Tissue Engineering." Thesis, 2012. http://hdl.handle.net/1911/70406.

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This thesis demonstrated the effects of exogenous stimuli on engineered articular cartilage constructs and elucidated mechanisms underlying the responses to these agents. In particular, a series of studies detailed the effects of chondroitinase-ABC (C-ABC), hyaluronic acid (HA), and TGF-β1 on the biochemical and biomechanical properties of self-assembled articular cartilage. Work with C-ABC showed that this catabolic agent can be employed to improve the tensile properties of constructs. When constructs were cultured for 6 weeks, treating with C-ABC at 2 weeks enhanced the tensile stiffness. Fu
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31

Hu, Kuei-Pao, and 胡貴寶. "Regeneration of Fine-Particle MSWI Bottom Ash by Chelating Agents Stabilization Accompany with Sintering Process." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/06192079971332773416.

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碩士<br>淡江大學<br>水資源及環境工程學系碩士班<br>93<br>At present, incineration is the main treatment way of the municipal solid waste in Taiwan. It produce large amount of ash and residuals. Some developed countries in Europe regenerate the bottom ash as construction aggregates. This study aim to increase the bottom ash value and environmental safety in the regeneration processes. This study include three part：Part A is washing procedure to wash out the chloride in bottom ash. Because chloride is harmful to the regeneration material of bottom ash; Part B is the stabilization. Using commercial chelating agen
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32

Höhme, Stefan [Verfasser]. "Agent-based modeling of growing cell populations and the regenerating liver based on image processing / vorgelegt von Stefan Höhme." 2010. http://d-nb.info/100896185X/34.

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33

Everhart, Adam R. "The Effects of Nano-Hydroxyapatite in a Double Antibiotic Paste-Loaded Methycellulose Carrier on Dental Pulp Stem Cells." Thesis, 2019. http://hdl.handle.net/1805/19683.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The effects of hydroxyapatite in a DAP-loaded MC carrier on dental pulp stem cells Introduction: Regenerative endodontic procedures (REP) require disinfection techniques to eliminate bacteria from the infected immature root canal system and promote new growth of the pulp-dentin complex. Double antibiotic paste (DAP), a mixture of ciprofloxacin and metronidazole, has shown efficacy in doing so while minimizing cytotoxicity on dental pulp stem cells (DPSC). Stem cells, scaffolding, and growth factors are necessary in the maturatio
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34

Epkey, Kathryn Eileen. "The antibacterial stability of a new radiopaque double antibiotic paste." Thesis, 2018. https://doi.org/10.7912/C2ND40.

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Indiana University-Purdue University Indianapolis (IUPUI); Graduate Endodontics, Masters degree thesis<br>We evaluated the antibacterial stability (shelf life) of a new radiopaque double antibiotic paste (RoDAP) loaded in a methylcellulose system with 30% w/v barium sulfate against biofilm collected from an immature tooth with necrotic pulp. Uniform radicular dentin specimens were infected with bacterial biofilm obtained from an immature tooth with a necrotic pulp and incubated anaerobically for three weeks. These samples were randomly divided into 6 experimental groups (n=7) and treated for 1
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Sibanda, Wanani Nonhlanhla. "The effect of antiretrovirals on myoblast proliferation : migration and differentation." Thesis, 2013. http://hdl.handle.net/10413/10551.

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Successful antiretroviral (ARV) treatment is associated with suppression of HIV viral load and the reduction of clinical disease progression. Despite marked improvements in ARV medication, side effects from long-term treatment, such as loss of muscle mass do occur. The mechanism by which ARVs affect muscle mass is unclear, however, published in vitro data suggests a negative effect on myoblast fusion during differentiation. The objective of this study was therefore to determine the effect of ARVs on processes required for successful myogenesis; these included proliferation, migration during wo
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36

Biggerstaff, Ross. "The residual antibacterial effects of radiopaque double antibiotic paste after various treatment times." Thesis, 2018. https://doi.org/10.7912/C2HM1P.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Introduction: Regenerative endodontic procedures require adequate disinfection of immature teeth with necrotic pulps. Regeneration endodontic procedures have been shown to increase width and length of dentin after disinfection of the root canal system with various antibiotic pastes such as double antibiotic paste (DAP). DAP is composed of an equal ratio of metronidazole and ciprofloxacin. After the root canal system is disinfected with DAP, it is later flushed out with 17-percent EDTA. There is a need for a radiopaque component in th
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Jacobs, Jordon C. "The ability of new intracanal medicaments to prevent the formation of multi-species biofilm on radicular dentin." Thesis, 2017. https://doi.org/10.7912/C2HD3C.

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Indiana University-Purdue University Indianapolis (IUPUI) Indiana University School of Dentistry Indiana University Endodontic Department<br>The residual antibacterial effects of antimicrobials used in endodontic regeneration against biofilm bacteria obtained from immature and mature teeth Jordon C. Jacobs DDS, Richard L Gregory PhD, Ygal Ehrlich DMD, Kenneth Spolnik DDS, MS, Josef S. Bringas DMD, DDS, MS, and Ghaeth Yassen BDS, MSD, PhD We explored the residual antibacterial properties of dentin pretreated with low concentrations of double antibiotic paste (DAP) against biofilm bacter
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Yassen, Ghaeth H. "The effect of endodontic regeneration medicaments on mechanical properties of radicular dentin." Thesis, 2013. http://hdl.handle.net/1805/3226.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Endodontic regeneration treatment of necrotic immature teeth has gained popularity in recent years. The approach suggests a biological alternative to induce a continuous root development. In this project, three in vitro experiments were conducted to investigate the effect of three medicaments used in endodontic regeneration on mechanical properties and chemical structure of radicular dentin. In the first experiment, we investigated longitudinally the effect of medicaments on the indentation properties of the root canal surface of imm
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Jenks, Daniel Brent. "The effects of concentration and treatment time on the residual antibacterial properties of DAP." Thesis, 2016. http://hdl.handle.net/1805/10233.

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Indiana University-Purdue University Indianapolis (IUPUI) Endodontic Regeneration Graduate Endodontic Department<br>Introduction: Regenerative endodontic procedures are used to treat immature teeth with pulpal necrosis in order to control infection, enable continued root development and enhance formation of a pulp like tissue in the canal. Canal disinfection is an integral part the regenerative endodontic process. Double antibiotic paste (DAP; i.e., equal parts of ciprofloxacin and metronidazole) has been successfully used for canal disinfection in regenerative endodontics. A comparison of t
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40

Alyas, Sarmad Mazin. "The Longevity of Residual Antibacterial Effect of Dentin Treated with Various Concentrations of Triple Antibiotic Paste." Thesis, 2016. http://hdl.handle.net/1805/10235.

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Indiana University School of Dentistry Department of Endodontics<br>Introduction: Triple antibiotic paste (TAP, 1000 mg/ml) is composed of equal portions of ciprofloxacin, metronidazole and minocycline and is used as an intracanal dressing to disinfect the infected immature root canal during endodontic regeneration procedures. Lower concentrations of TAP have been recommended to minimize detrimental effects on pulp stem cells. TAP can be retained within the dentin matrix and its continual release confers an antibacterial effect to the dentin. Objective: The aim of this in vitro study was to i
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41

Fennessy, Barbara Ann. "Communities and Leaders at Work in the New Economy: A Comparative Analysis of Agents of Transformation in Pittsburgh, Pennsylvania and Hamilton, Ontario." Thesis, 2009. http://hdl.handle.net/1807/19144.

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Without change, stagnation is inevitable. Never has this truth been more obvious than during the current epoch of industrial decline in North America. This research provides two economic narratives that exemplify the struggles of industrial communities as they strive to regenerate. The research involves a comparative analysis of the transformation of two steel cities, Pittsburgh, Pennsylvania, and Hamilton, Ontario, from 1970 to 2008. For cities in which one major industry has formed the foundation of the local economy, job losses can result in massive dislocation and devastating consequences
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Xue, J., M. He, H. Liu, et al. "Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes." 2014. http://hdl.handle.net/10454/8028.

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Yes<br>Infection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0, 1, 5, 10, 20, 30, and 40 wt.% of polymer) on the properties of th
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Ibrahim, Carolin Francis. "The antibacterial effects of radiopaque double antibiotic pastes against clinical bacterial isolates from mature and immature teeth with necrotic pulps." Thesis, 2018. https://doi.org/10.7912/C2S36W.

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Low concentrations (1-10mg/mL) of double antibiotic paste (DAP) have demonstrated antibacterial properties in regenerative endodontics. The aim of this study was to evaluate if DAP made radiopaque (RoDAP) with barium sulfate has antibacterial effects against bacterial isolates from a mature and immature tooth with necrotic pulp. Clinical bacterial isolates were obtained from the canals of mature and immature teeth with necrotic pulps during root canal therapy or a regenerative procedure, respectively. Bacterial isolates were grown anaerobically for three weeks on 4x4mm dentin specimens prepar
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Jeppson, John Keith. "Antimicrobial properties of drug-containing electrospun scaffolds." Thesis, 2012. http://hdl.handle.net/1805/3169.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Endodontic treatment of the infected immature tooth has undergone a dramatic change. Conventional endodontic treatment can control infection, but root development usually remains impaired. A novel regenerative endodontic procedure, the revascularization method, can now control the infection and enable such teeth to continue root development. This is done by creating a fibrin-matrix scaffold in the antibiotic treated root canal space (RCS). Dental stem cells and growth factors have been able to continue root development in such an en
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Sabrah, Ala'a Hussein Aref 1984. "Diluted antibiotics for treating traumatized immature teeth." Thesis, 2014. http://hdl.handle.net/1805/6500.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Endodontic regeneration (ERP) has been successfully used in the treatment of traumatized immature teeth. The procedure has three essential steps: disinfecting the root canal (i.e. triple antibiotic paste (TAP) or double antibiotic paste (DAP)), provoking bleeding inside the canal to form a scaffold upon which pulp stem cells will be deposited and continue root growth, and creating a good coronal seal. Previous research has reported that antibiotic pastes (TAP and DAP) are cytotoxic to stem cells in the concentrations commonly used i
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Kim, Ki Wan. "The effects of radicular dentin treated with double antibiotic paste and EDTA on dental pulp stem cell proliferation : an in-vitro study." Thesis, 2014. http://hdl.handle.net/1805/6504.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Introduction: Regenerative endodontic therapy in immature teeth promotes continuation of root development and likely increases the prognosis of these teeth. The use of double antibiotic paste (DAP), equal parts of ciprofloxacin and metronidazole, followed by the dentin conditioner, ethylenediaminetetraacetic acid (EDTA), has been suggested for canal disinfection and facilitation of stem cell attachment/proliferation, respectively. However, the effect is unknown when all these agents are used on on radicular dentin surfaces to facil
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Fischer, Benjamin I. "The impact of hydroxyapatite on alkaline phosphatase activity and mineral deposition of dental pulp stem cells using a double antibiotic paste loaded methylcellulose carrier." Thesis, 2020. http://hdl.handle.net/1805/23133.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Introduction: Regenerative endodontic procedures (REPs) are a type of endodontic treatment aimed at replacing damaged tooth structures, including dentin and root structures, as well as cells of the pulp-dentin complex. Double antibiotic paste (DAP) has been shown to be efficacious in achieving disinfection of the root canal system while minimizing cytotoxicity to dental pulp stem cells (DPSCs). Hydroxyapatite (HA) is an extracellular, mineralized component of bone that has shown much promise as a scaffold in the field of regenerative
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Xue, J., M. He, Y. Niu, et al. "Preparation and in vivo efficient anti-infection property of GTR/GBR implant made by metronidazole loaded electrospun polycaprolactone nanofiber membrane." 2014. http://hdl.handle.net/10454/10813.

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No<br>Infection is the major reason of GTR/GBR membrane failure in clinical application. In this work, we developed GTR/GBR nanofiber membranes with localized drug delivery function to prevent infection. Metronidazole (MNA), an antibiotic, was successfully incorporated into electrospun polycaprolactone (PCL) nanofibers at different concentrations (0, 1, 5, 10, 20, 30, and 40 wt% polymer). To obtain the optimum anti-infection membrane, we systematically investigated the physical-chemical and mechanical properties of the nanofiber membranes with different drug contents. The interaction between P
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Yaghmoor, Rayan Bahjat M. "Effect of low concentrations of antibiotic intracanal medicaments on crown discoloration and push-out bond strength." Thesis, 2018. https://doi.org/10.7912/C2DQ0D.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Introduction: Some intracanal medicaments used in regenerative endodontics may compromise the bond strength of root cements and lead to tooth discoloration. Objectives: To evaluate the effects of 1) low concentrations of TAP and DAP (1 mg/mL) on push-out bond strength of various root cements, and 2) low concentrations of TAP and DAP (1 mg/mL and 10 mg/mL) on crown discoloration. Materials and Methods: Single rooted human teeth (n = 144) were horizontally decoronated and instrumented according to standardized protocol. The samples w
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Prather, Blake. "Effect of Antibiotic Pastes on Chemical Structure and Microhardness of Radicular Dentin." Thesis, 2014. http://hdl.handle.net/1805/6503.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Introduction: Regenerative endodontic therapy in immature teeth with necrotic pulps triggers continued root development, thereby improving the prognosis of these teeth. Disinfection of the canal is accomplished with an intracanal medicament, such as triple antibiotic paste (TAP) composed of metronidazole, ciprofloxacin, and minocycline. A modified triple antibiotic paste (MTAP) that replaces minocycline with clindamycin has recently been suggested to avoid the tooth discoloration and potential demineralization from minocycline. T
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