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Journal articles on the topic 'Regenerative Agent'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sosnowski, Paweł, Piotr Sass, Paulina Słonimska, et al. "Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice." Pharmaceuticals 15, no. 5 (2022): 610. http://dx.doi.org/10.3390/ph15050610.

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The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna wound closure in BALB/c mice. Our previous research demonstrated that a DNA methyltransferase inhibitor, zebularine, remarkably induced ear pinna regeneration. Altho

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Yi, Qigui, Nan Ru, and Jianyi Gu. "Research Based on the Selection of Regenerative Agents Based on Molecular Simulation New-Old Asphalt Diffusion Behavior." E3S Web of Conferences 406 (2023): 01037. http://dx.doi.org/10.1051/e3sconf/202340601037.

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In order to understand the new-old asphalt diffusion behavior, use the Materials Studio (MS) molecular dynamic simulation software to build a matrix asphalt and aging asphalt molecular model based on the average molecular model of the asphalt, and select the appropriate force field and potential energy function. As well as parameters such as boundary conditions, set up as-phalt-regenerative dot-shaped contact models and laminar contact models. From the perspective of molecular perspectives, the diffusion behavior between the old and new asphalt and the re-generative agent is analyzed. The prom

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Tarasova, Viktorija, and Mikhail Kuznetsov. "Analyzing the Thermodynamic Efficiency of Cooling Cycles Depending on the Determinant Thermal and Physical Properties of Operating Media." NTU "KhPI" Bulletin: Power and heat engineering processes and equipment, no. 1 (October 28, 2021): 60–70. http://dx.doi.org/10.20998/2078-774x.2021.01.10.

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The goal of this research was to develop the methods used for the analysis of the thermodynamic efficiency of the ordinary single-stage and regenerative cooling cycles depending on the determinant thermal-&-physical properties of cooling agents. The thermodynamic efficiency of the steam –compressive single-stage ordinary and regenerative cycles of cooling machines operating on different cooling agents has been investigated. The dependence was established between the effectiveness value of the use of the regeneration for the cooling cycle and the modified Clausius criterion of the cooling a

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Li, Feifei, Peipei Jiang, Jinhai Pan, Chengcheng Liu, and Liwei Zheng. "Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis." BioMed Research International 2019 (August 18, 2019): 1–12. http://dx.doi.org/10.1155/2019/9148183.

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Periodontal bone regeneration relies on coupled and cooperative bone formation and resorption. Accordingly a novel strategy on concurrent use of platelet-rich fibrin (PRF) (anabolic agent) and 1% alendronate (ALN) (anticatabolic agent) was proposed recently in regenerative periodontal treatment. It was supposed to enhance bone formation and reduce bone resorption simultaneously. However, there is a lack of evidence-based studies to answer whether this concurrent application was superior to single application until now. Besides, concerns on ALN lead to some reservation on this synergistic way.

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Da, Lin-Cui, Yan Sun, Yun-Hong Lin, et al. "Emerging Bioactive Agent Delivery-Based Regenerative Therapies for Lower Genitourinary Tissues." Pharmaceutics 14, no. 8 (2022): 1718. http://dx.doi.org/10.3390/pharmaceutics14081718.

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Injury to lower genitourinary (GU) tissues, which may result in either infertility and/or organ dysfunctions, threatens the overall health of humans. Bioactive agent-based regenerative therapy is a promising therapeutic method. However, strategies for spatiotemporal delivery of bioactive agents with optimal stability, activity, and tunable delivery for effective sustained disease management are still in need and present challenges. In this review, we present the advancements of the pivotal components in delivery systems, including biomedical innovations, system fabrication methods, and loading

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Al-Sowayan, Batla, Farah Alammari, and Alaa Alshareeda. "Preparing the Bone Tissue Regeneration Ground by Exosomes: From Diagnosis to Therapy." Molecules 25, no. 18 (2020): 4205. http://dx.doi.org/10.3390/molecules25184205.

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Bone tissue engineering employs acellular scaffolds or scaffolds, along with cells and growth factors, to provide the mechanical support needed, as well as serve as a delivery vehicle for bioactive molecules to the injury sites. As tissue engineering continues to evolve, it has integrated two emerging fields: stem cells and nanotechnology. A paracrine factor that is found to be responsible for the major regenerative effect in stem cell transplantation is an extracellular vesicle called an ‘exosome’. Recent advances in nanotechnology have allowed the ‘exosome’ to be distinguished from other ext

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Ghomeshi, Mohsen, and Bartosz Walczak. "Water as an Agent of Urban Regeneration in Postindustrial areas." BUILDER 303, no. 10 (2022): 85–87. http://dx.doi.org/10.5604/01.3001.0015.9985.

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The aim of the research is to open the discussion of role of water bodies as an agent in the process of urban regeneration. Finding sustainable solutions to foster the regeneration schemes in postindustrial urban areas has become an important and updated subject in field of architecture and urban planning. Considering the importance of water in 21st century and numerous water-related postindustrial urban spaces, it seems crucial to build a regenerative relationship between water bodies and postindustrial urban sites. This paper will try to indicate the water bodies and the potential within usi

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Stella, Salvatore L., Jasmine S. Geathers, Sarah R. Weber, et al. "Neurodegeneration, Neuroprotection and Regeneration in the Zebrafish Retina." Cells 10, no. 3 (2021): 633. http://dx.doi.org/10.3390/cells10030633.

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Neurodegenerative retinal diseases, such as glaucoma and diabetic retinopathy, involve a gradual loss of neurons in the retina as the disease progresses. Central nervous system neurons are not able to regenerate in mammals, therefore, an often sought after course of treatment for neuronal loss follows a neuroprotective or regenerative strategy. Neuroprotection is the process of preserving the structure and function of the neurons that have survived a harmful insult; while regenerative approaches aim to replace or rewire the neurons and synaptic connections that were lost, or induce regrowth of

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Khan, Anish Murtaja Alam, Nusrat Nabi, Gholamreza Abdi та ін. "Human Pancreatic β Cell Regenerative Therapy: Exploring the Role of Chicoric Acid as a Phytochemical Candidate". Journal of Phytopharmacology 13, № 2 (2024): 105–13. http://dx.doi.org/10.31254/phyto.2024.13204.

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Diabetes is a global health issue, impacting life expectancy and productivity. Pathogenesis of diabetes mellitus involves decreased functional beta cells, making beta cell replacement and regeneration a crucial area of research. However, current methods like whole pancreas transplant or stem cell-derived beta cells have limitations for diabetic patients. Exploring pharmacological approaches to stimulate regeneration of residual beta cells is valuable, as many diabetic patients retain some beta cells. Finding drugs that target and regenerate these cells effectively is a challenge, with no appro

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Rodrigues, Simone, Mariana Fornazier, Denildo Magalhães, and Reinaldo Ruggiero. "Potential utilization of glycerol as crosslinker in starch films for application in Regenerative Dentistry." Research, Society and Development 10, no. 16 (2021): e148101623640. http://dx.doi.org/10.33448/rsd-v10i16.23640.

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Periodontal disease results in damage to dental insertion apparatus. Regenerative procedures are proposed to replace lost structures in the context of guided tissue regeneration (GTR), guided bone regeneration (GBR) techniques and frequently associate bone substitutes with physical barriers aiming at greater longevity and improvement of aesthetic pattern. This study evaluates the possibility of using glycerol as a starch films modifying agent, acting as a cross-linking agent, without compromising its plasticizing effect. Biodegradable cassava starch films were prepared incorporating glycerol a

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Burke, John, Ravindra Kolhe, Monte Hunter, Carlos Isales, Mark Hamrick, and Sadanand Fulzele. "Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics." Stem Cells International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/5802529.

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Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. Because of this, there are vast benefits that medicine can obtain from s

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Park, Gi Young, and Byeong-Churl Jang. "Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety." Keimyung Medical Journal 44, no. 1 (2025): 9–18. https://doi.org/10.46308/kmj.2025.00115.

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Polydeoxyribonucleotide (PDRN), a highly purified salmon‑sperm–derived DNA polymer, exhibits potent regenerative and anti-inflammatory effects. This review critically explores the dual mechanisms of PDRN—namely, adenosine A2A receptor activation and nucleotide provision via the salvage pathway—and synthesizes the current clinical evidence regarding its applications in dermatology and wound healing. Preclinical and clinical studies have shown that PDRN enhances angiogenesis, modulates cytokine profiles, and accelerates tissue repair processes, resulting in improved healing rates in chronic diab

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Kim, Gang-Un, Soo-Eun Sung, Kyung-Ku Kang, et al. "Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury." International Journal of Molecular Sciences 22, no. 24 (2021): 13672. http://dx.doi.org/10.3390/ijms222413672.

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Spinal cord injury (SCI) is a life-threatening condition that leads to permanent disability with partial or complete loss of motor, sensory, and autonomic functions. SCI is usually caused by initial mechanical insult, followed by a cascade of several neuroinflammation and structural changes. For ameliorating the neuroinflammatory cascades, MSC has been regarded as a therapeutic agent. The animal SCI research has demonstrated that MSC can be a valuable therapeutic agent with several growth factors and cytokines that may induce anti-inflammatory and regenerative effects. However, the therapeutic

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Jarrah, Ryan, Sally El Sammak, Chiduziem Onyedimma, et al. "The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature." Neurospine 19, no. 2 (2022): 272–80. http://dx.doi.org/10.14245/ns.2244186.093.

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Objective: To comprehensively characterize the utilization of alginate hydrogels as an alternative treatment modality for spinal cord injury (SCI).Methods: An extensive review of the published literature on studies using alginate hydrogels to treat SCI was performed. The review of the literature was performed using electronic databases such as PubMed, EMBASE, and OVID MEDLINE electronic databases. The keywords used were “alginate,” “spinal cord injury,” “biomaterial,” and “hydrogel.”Results: In the literature, we identified a total of 555 rat models that were treated with alginate scaffolds fo

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Sulistiawati, Yanti Rusyanti, Ina Hendiani, Mas Rizky Anggun Adipurna Syamsunarno, and Zavani Nur Hikmah. "Effect of 0.1% Genipin as a Crosslinking Agent to Degradability of Platelet Rich Fibrin (PRF)." Key Engineering Materials 829 (December 2019): 258–62. http://dx.doi.org/10.4028/www.scientific.net/kem.829.258.

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Platelet-rich fibrin (PRF) was developed as a barrier membrane in periodontal regenerative therapy. It is known that PRF has a sustained released of growth factor and expected to facilitate the tissue regeneration. Since the PRF membranes have a rapid degradability (1-2 weeks), the regenerative therapy using a PRF membrane should be increased to reduce the degradability using a crosslinking agent which could provide resistance against enzymatic degradation. The aim of this study is to analyze the effect of 0.1% genipin as a crosslinking agent to degradability of PRF. PRF membranes were prepare

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Ismiyatin, Kun, Febriastuti Cahyani, Adioro Soetojo, et al. "Epigallocatechin-3-gallate (EGCG) and tricalcium silicate (C_3 S) combination as an antibacterial agent against Enterococcus faecalis." Conservative Dentistry Journal 15, no. 1 (2025): 46–48. https://doi.org/10.20473/cdj.v15i1.2025.46-48.

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Background: Dental caries affects 57.6% of the Indonesian population, with Enterococcus faecalis found in 80% of deep caries cases. Conventional materials used in vital pulp therapy (VPT), such as calcium hydroxide, have limitations including transient antibacterial action and poor sealing capacity. This prompts the exploration of alternative materials like epigallocatechin-3-gallate (EGCG), a polyphenol from green tea with antimicrobial activity, and tricalcium silicate (C₃S), a bioactive cement known for dentin regeneration potential. Purpose: This review evaluates the synergistic antibacter

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Antoshin, Artem A., Anastasia I. Shpichka, Guilin Huang, et al. "Lactoferrin as a regenerative agent: The old-new panacea?" Pharmacological Research 167 (May 2021): 105564. http://dx.doi.org/10.1016/j.phrs.2021.105564.

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18

Müller, Anna Sonja, Milot Gashi, Klara Janjić, Michael Edelmayer, Andreas Moritz, and Hermann Agis. "The impact of clay-based hypoxia mimetic hydrogel on human fibroblasts of the periodontal soft tissue." Journal of Biomaterials Applications 33, no. 9 (2019): 1277–84. http://dx.doi.org/10.1177/0885328218821042.

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Thixotropic clays have favorable properties for tissue regeneration. Hypoxia mimetic agents showed promising results in pre-clinical models for hard and soft tissue regeneration. It is unclear if clays can be used as carrier for hypoxia mimetic agent in a periodontal regenerative setting. Here, we tested the response of human fibroblasts of the periodontal soft tissue to synthetic clay hydrogels and assessed hypoxia mimetic agent release. Cells were cultured on synthetic clay hydrogels (5.00%–0.15%). We assessed viability and differentiation capacity with resazurin-based toxicity assays, MTT s

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Virgilio, Kelley M., Kyle S. Martin, Shayn M. Peirce, and Silvia S. Blemker. "Agent-based model illustrates the role of the microenvironment in regeneration in healthy and mdx skeletal muscle." Journal of Applied Physiology 125, no. 5 (2018): 1424–39. http://dx.doi.org/10.1152/japplphysiol.00379.2018.

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Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease with no effective treatment. Multiple mechanisms are thought to contribute to muscle wasting, including increased susceptibility to contraction-induced damage, chronic inflammation, fibrosis, altered satellite stem cell (SSC) dynamics, and impaired regenerative capacity. The goals of this project were to 1) develop an agent-based model of skeletal muscle that predicts the dynamic regenerative response of muscle cells, fibroblasts, SSCs, and inflammatory cells as a result of contraction-induced injury, 2) calibrate and va

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20

Gu, Fang, and Qian Nie. "Preparation of LiCoO₂ from Cathode Materials of Spent Lithium Ion Batteries." Advanced Materials Research 183-185 (January 2011): 1553–57. http://dx.doi.org/10.4028/www.scientific.net/amr.183-185.1553.

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Preparation of LiCoO2 cathode materials from spent lithium ion batteries are presented. The processes contain reduction, separation, precipitation, regeneration. The optimum conditions of recovery are: the calcination temperature is 500°C, the volume rate of sulfuric acid and the water reaches 0.375, the hightest leach-ing rate of cobalt is 43.53%. According to the solubility of oxalate, ammonium oxalate is choiced as precipitation agent. The investigation of X-ray diffraction (XRD), scanning electron microscopy (SEM), charge-discharge testes at voltage ranges rate from 2.8V to 4.2V versus Li

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Vinayaka, Ambujakshi Manjunatha. "Advancements and clinical applications of extended platelet-rich fibrin (E-PRF)." Journal of Orofacial and Health Sciences 11, no. 4 (2024): 162–64. http://dx.doi.org/10.18231/j.johs.2024.032.

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Extended platelet-rich fibrin (E-PRF) has emerged as a potent biological agent in regenerative medicine and dentistry. It leverages the natural healing capacities of growth factors and cytokines from platelets and leukocytes to promote tissue repair. This systematic review explores the role of E-PRF in various clinical applications, including wound healing, bone regeneration, and periodontal therapy. The findings indicate that E-PRF provides an enhanced bioactive matrix, supporting superior clinical outcomes compared to conventional treatments. Future studies should focus on optimizing E-PRF p

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Li, Zhongguang, Liyang Wang, Huimin Yue, et al. "MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine." Cells 10, no. 1 (2021): 122. http://dx.doi.org/10.3390/cells10010122.

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Under natural conditions, injured cells can be repaired rapidly through inherent biological processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy, and other degenerative conditions, the natural repair process is impaired. Repair of injury to the cell membrane is an important aspect of physiology. Inadequate membrane repair function is implicated in the pathophysiology of many human disorders. Recent studies show that Mitsugumin 53 (MG53), a TRIM family protein, plays a key role in repairing cell membrane damage and facilitating tissue regeneration. Clarifying

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Li, Zhongguang, Liyang Wang, Huimin Yue, et al. "MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine." Cells 10, no. 1 (2021): 122. http://dx.doi.org/10.3390/cells10010122.

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Under natural conditions, injured cells can be repaired rapidly through inherent biological processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy, and other degenerative conditions, the natural repair process is impaired. Repair of injury to the cell membrane is an important aspect of physiology. Inadequate membrane repair function is implicated in the pathophysiology of many human disorders. Recent studies show that Mitsugumin 53 (MG53), a TRIM family protein, plays a key role in repairing cell membrane damage and facilitating tissue regeneration. Clarifying

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Faizurrahman Andi Kusuma, Sigit Adi Prasetyo, and Endang Sri Lestari. "Modulation of Inflammatory and Regenerative Pathways by Channa striata Extract in End-to-End Anastomotic Wound Repair: A Systematic Review." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 4 (2025): 7163–76. https://doi.org/10.37275/bsm.v9i4.1264.

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Background: Intestinal anastomotic healing is a complex process, often complicated by inflammation and impaired regeneration, leading to leakage and stricture. Channa striata (snakehead fish) extract, traditionally used for wound healing, possesses bioactive compounds with potential anti-inflammatory and regenerative properties. This systematic review aimed to critically appraise the in vivo evidence for the effects of Channa striata extract on inflammatory and regenerative pathways in end-to-end anastomotic wound repair. Methods: A comprehensive search of PubMed/MEDLINE, Scopus, Web of Scienc

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Kuten Pella, Olga, István Hornyák, Dénes Horváthy, Eszter Fodor, Stefan Nehrer, and Zsombor Lacza. "Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine." International Journal of Molecular Sciences 23, no. 18 (2022): 10557. http://dx.doi.org/10.3390/ijms231810557.

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Albumin is a constitutional plasma protein, with well-known biological functions, e.g., a nutrient for stem cells in culture. However, albumin is underutilized as a biomaterial in regenerative medicine. This review summarizes the advanced therapeutic uses of albumin, focusing on novel compositions that take advantage of the excellent regenerative potential of this protein. Albumin coating can be used for enhancing the biocompatibility of various types of implants, such as bone grafts or sutures. Albumin is mainly known as an anti-attachment protein; however, using it on implantable surfaces is

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Martinotti, Simona, Marcela Bucekova, Juraj Majtan, and Elia Ranzato. "Honey: An Effective Regenerative Medicine Product in Wound Management." Current Medicinal Chemistry 26, no. 27 (2019): 5230–40. http://dx.doi.org/10.2174/0929867325666180510141824.

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:Honey has successfully been used in the treatment of a broad spectrum of injuries including burns and non-healing wounds. It acts as an antibacterial and anti-biofilm agent with anti/pro-inflammatory properties. However, besides these traditional properties, recent evidence suggests that honey is also an immunomodulator in wound healing and contains several bee and plant-derived components that may speed up wound healing and tissue regeneration process. Identifying their exact mechanism of action allows better understanding of honey healing properties and promotes its wider translation into c

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Siegel, Fabian, Angelo Torelli, Minca Mattis, Julian Debatin, Philipp Erben, and Markus Gumbel. "Proliferation and regeneration of the healthy human urothelium: A multi-scale simulation approach with 16 hypotheses of cell differentiation." PLOS One 20, no. 6 (2025): e0325132. https://doi.org/10.1371/journal.pone.0325132.

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The urothelium as a stratified epithelium of the urinary tract is a slow regenerating tissue of different layers and shares similarities with the epidermis. Characteristics of its cell types, regeneration, tissue homeostasis, integrity and self organization are only partly understood. Precise computer-based models which investigate the cell kinetics of the urothelium from a theoretical perspective are beneficial for the regenerative medicine field and cancer research. Here an agent-based computer simulation based on the Glazier-Graner-Hogeweg (GGH) approach were developed and tested on 16 hypo

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Binjhade, Neha, Vinanti Supare, Shailesh Ghaywat, Sagar Trivedi, Kamlesh Wadher, and Milind Umekar. "Agmatine: A potential Neurotherapeutic Agent." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 88–92. http://dx.doi.org/10.22270/jddt.v11i4.4855.

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Agmatine, a natural polyamine disregarded almost for over 100 years, was discovered in year 1910. Almost after a decade, several researches on Agmatine indicated its modulatory action at multiple molecular targets such as, nitric oxide synthesis, neurotransmitter systems, and polyamine metabolism unbolt the new avenues for extensive therapeutic applications which includes neurotrauma and neurodegenerative diseases, antidepressant, cognitive disorders. Agmatine exerts its varied biological characteristics and therapeutic potential in diverse arena. Agmatine has been extensively researched for i

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Zhao, Zelong, Dandan Yin, Kexin Yang, Chunmei Zhang, Linxia Song, and Zhenbiao Xu. "Transcriptome Sequencing Analysis of the Effects of Metformin on the Regeneration of Planarian Dugesia japonica." Genes 16, no. 4 (2025): 365. https://doi.org/10.3390/genes16040365.

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Background: Metformin is a widely used oral hypoglycemic agent for treating type 2 diabetes. Planarians, with their remarkable regenerative abilities, are frequently employed as model organisms in stem cell and regeneration studies. This study aimed to investigate the effects of metformin on planarian regeneration, focusing on the regeneration of eyespots after amputation. Methods: Regenerating planarians with amputated eyespots were exposed to various concentrations of metformin. The regeneration time of the eyespots was measured to assess the effects of metformin. Subsequently, a 1 mmol/L me

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Hara, Shuta, Akiko Kojima, Atsushi Furukawa та ін. "Mechanical Properties and Decomposition Behavior of Compression Moldable Poly(Malic Acid)/α-Tricalcium Phosphate Hybrid Materials". Polymers 17, № 2 (2025): 147. https://doi.org/10.3390/polym17020147.

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Calcified tissues in living organisms, such as bone, dentin, and enamel, often require surgical intervention for treatment. However, advances in regenerative medicine have increased the demand for materials to assist in regenerating these tissues. Among the various forms of calcium phosphate (CaP), tricalcium phosphate (TCP)—particularly its α-TCP form—stands out due to its high solubility and efficient calcium release, making it a promising candidate for bone regeneration applications. Nevertheless, its rapid dissolution rate presents challenges when used as a reinforcing agent. In this study

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Pishavar, Elham, Fatemeh Khosravi, Mahshid Naserifar, et al. "Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo." Polymers 13, no. 16 (2021): 2680. http://dx.doi.org/10.3390/polym13162680.

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Regenerative medicine seeks to assess how materials fundamentally affect cellular functions to improve retaining, restoring, and revitalizing damaged tissues and cancer therapy. As potential candidates in regenerative medicine, hydrogels have attracted much attention due to mimicking of native cell-extracellular matrix (ECM) in cell biology, tissue engineering, and drug screening over the past two decades. In addition, hydrogels with a high capacity for drug loading and sustained release profile are applicable in drug delivery systems. Recently, self-healing supramolecular hydrogels, as a nove

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NA, Kamaruzaman, Sulaiman SA, Gurjeet K, and Yahaya BH. "Aerosolized Honey as a Regenerative Agent in Animal Model of Asthma." Open Conference Proceedings Journal 4, no. 1 (2013): 289. http://dx.doi.org/10.2174/2210289201304010289.

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Gao, Xiaotian, Yu Du, Shiyuan Han, et al. "Multi-agent reinforcement learning for vibration control of regenerative active suspension." Engineering Applications of Artificial Intelligence 153 (August 2025): 110809. https://doi.org/10.1016/j.engappai.2025.110809.

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Giebel, Bernd, Verena Börger, Mario Gimona, and Eva Rohde. "From mesenchymal stem cells and stromal cells - from bench to bedside." How cells communicate - an introduction to extracellular vesicles 1, no. 1 (2019): 36–39. http://dx.doi.org/10.47184/tev.2019.01.05.

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Human mesenchymal stem/stromal cells (MSCs) represent a promising tool in regenerative medicine. Until now, almost one thousand NIH-registered clinical trials investigated their immunomodulatory and pro-regenerative therapeutic potential in various diseases. Despite controversial reports regarding the efficacy of MSC-treatments, MSCs appear to exert their beneficial effects in a paracrine manner rather than by cell replacement. In this context, extracellular vesicles (EVs), such as exosomes and microvesicles, seem to induce the MSCs’ therapeutic effects. Here, we briefly illustrate the potenti

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Yan, Shi, Li Nie, Juan Ren, et al. "Complex Agent for Phosphate Sequestration from Digested Sludge Liquor: Performances and Economic Cost Analysis." Processes 11, no. 7 (2023): 2050. http://dx.doi.org/10.3390/pr11072050.

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Phosphorus (P) management in the “water-energy-resource-nexus” in wastewater treatment plants (WWTPs) remains a longstanding challenge. P adsorption from the P-enriched digested sludge liquor (DSL) is a comparatively more practical and economically viable approach for P recovery in WWTPs. However, high concentrations of impurities in DSL might pose a negative and interferential effect on P adsorption, hindering the application of sorbents or precipitation methods. Given such a situation, highly efficient and cost-effective sorbent towards P reclamation from DSL is highly needed. Therefore, thi

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Genovese, Jorge A., and Howard J. Leonhardt. "Klotho, an Anti-Aging Protein with Significant Potential in Regenerative Medicine." MedLiber of Regenerative Medicine 02, no. 01 (2024): 34–44. http://dx.doi.org/10.55828/mrm-21-03.

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Aging is a continuous physiological process that results in senescence or a decline in biological functions. This process is triggered by changes in the body's ability to respond to stress and to adapt to metabolic shifts. As a natural course of events, it leads to the emergence of various health issues and limitations in the capacity to repair tissues and organs. Contemporary medicine aims to delay or modify this process and minimize the consequences of alterations in physical activity, nutritional parameters, and risks. The success of this protective approach is largely dependent on the rest

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Kazimierczak, Paulina, Krzysztof Palka, and Agata Przekora. "Development and Optimization of the Novel Fabrication Method of Highly Macroporous Chitosan/Agarose/Nanohydroxyapatite Bone Scaffold for Potential Regenerative Medicine Applications." Biomolecules 9, no. 9 (2019): 434. http://dx.doi.org/10.3390/biom9090434.

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Bone scaffolds mimicking the three-dimensional bone structure are of essential importance for bone regeneration. The aim of this study was to develop and optimize the production method of highly macroporous bone scaffold composed of polysaccharide matrix (chitosan–agarose) reinforced with nanohydroxyapatite. The highly macroporous structure was obtained by the simultaneous application of a gas-foaming agent and freeze-drying technique. Fabricated variants of biomaterials (produced using different gas-foaming agent and solvent concentrations) were subjected to porosity evaluation and compressio

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Dasari, Akshith, Jingyi Xue, and Sanjukta Deb. "Magnetic Nanoparticles in Bone Tissue Engineering." Nanomaterials 12, no. 5 (2022): 757. http://dx.doi.org/10.3390/nano12050757.

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Large bone defects with limited intrinsic regenerative potential represent a major surgical challenge and are associated with a high socio-economic burden and severe reduction in the quality of life. Tissue engineering approaches offer the possibility to induce new functional bone regeneration, with the biomimetic scaffold serving as a bridge to create a microenvironment that enables a regenerative niche at the site of damage. Magnetic nanoparticles have emerged as a potential tool in bone tissue engineering that leverages the inherent magnetism of magnetic nano particles in cellular microenvi

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Cao, Shan, Bao Zhen Cheng, Hai Li Zhang, and Guo Wei Geng. "Application of CRBD to Reducing Pollution of Leather Tanning Wastewater." Advanced Materials Research 800 (September 2013): 593–96. http://dx.doi.org/10.4028/www.scientific.net/amr.800.593.

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Trivalent chrome has an abroad application in the area of leather tanning, electrolytic plating and dyeing due to the strong capability of coordination. Pollution caused by chrome salts cannot be ignored. This paper proved that the chrome tanning wastewater can be treatment by chrome chelates (CRBD). The supernatant was reused in washing and pickling process and chromium sludge was utilized to make regeneration chrome-tanning agents; which all not only protect the environment but also save production cost. A series of experiment results showed that SO42-and oil contents increased slightly as w

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Vallejo, Mariana C. S., Nuno M. M. Moura, Maria Amparo Ferreira Faustino, et al. "An Insight into the Role of Non-Porphyrinoid Photosensitizers for Skin Wound Healing." International Journal of Molecular Sciences 22, no. 1 (2020): 234. http://dx.doi.org/10.3390/ijms22010234.

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The concept behind photodynamic therapy (PDT) is being successfully applied in different biomedical contexts such as cancer diseases, inactivation of microorganisms and, more recently, to improve wound healing and tissue regeneration. The effectiveness of PDT in skin treatments is associated with the role of reactive oxygen species (ROS) produced by a photosensitizer (PS), which acts as a “double agent”. The release of ROS must be high enough to prevent microbial growth and, simultaneously, to accelerate the immune system response by recruiting important regenerative agents to the wound site.

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Ahmed, Md Shahriar, Sua Yun, Hae-Yong Kim, Sunho Ko, Mobinul Islam, and Kyung-Wan Nam. "Hydrogels and Microgels: Driving Revolutionary Innovations in Targeted Drug Delivery, Strengthening Infection Management, and Advancing Tissue Repair and Regeneration." Gels 11, no. 3 (2025): 179. https://doi.org/10.3390/gels11030179.

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Hydrogels and microgels are emerging as pivotal platforms in biomedicine, with significant potential in targeted drug delivery, enhanced infection management, and tissue repair and regeneration. These gels, characterized by their high water content, unique structures, and adaptable mechanical properties, interact seamlessly with biological systems, making them invaluable for controlled and targeted drug release. In the realm of infection management, hydrogels and microgels can incorporate antimicrobial agents, offering robust defenses against bacterial infections. This capability is increasing

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Harrell, Carl Randall, Crissy Fellabaum, Bojana Simovic Markovic, Aleksandar Arsenijevic, and Vladislav Volarevic. "Therapeutic Potential of “Exosomes Derived Multiple Allogeneic Proteins Paracrine Signaling: Exosomes d-MAPPS” is Based on the Effects of Exosomes, Immunosuppressive and Trophic Factors." Serbian Journal of Experimental and Clinical Research 20, no. 3 (2019): 189–97. http://dx.doi.org/10.2478/sjecr-2018-0032.

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Abstract Due to their differentiation capacity and potent immunosuppressive and pro-angiogenic properties, mesenchymal stem cells (MSCs) have been considered as new therapeutic agents in regenerative medicine. Since most of MSC-mediated beneficent effects are a consequence of their paracrine action, we designed MSC-based product “Exosomes Derived Multiple Allogeneic Proteins Paracrine Signaling (Exosomes d-MAPPS), which activity is based on MSCs-derived growth factors and immunomodulatory cytokines capable to attenuate inflammation and to promote regeneration of injured tissues. Interleukin 1

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Jin, Xin, Haoxuan Fu, Deli Li, et al. "Research on the Preparation and Performance of Biomimetic Warm-Mix Regeneration for Asphalt Mixtures." Coatings 14, no. 7 (2024): 825. http://dx.doi.org/10.3390/coatings14070825.

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To determine the formula for biomimetic warm-mix regeneration and fulfill the requirements of a “high waste asphalt mixture content, high quality, and high level” for its usage in reclaimed asphalt pavement (RAP), this paper first determined the suitable preparation process and formula for biomimetic warm-mix regeneration based on orthogonal experiments and a gray correlation analysis. Then, the optimum dosage of the warm-mix regenerant was determined by a uniaxial penetration test, low-temperature splitting test, and freeze–thaw penetration test. The rutting test was conducted to characterize

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Al-Khalisy, Ma’an, and Ahmed Al-Imam. "Commercial Acetic Acid: A Potential Regenerative Agent for Chronic Cutaneous Wounds? A Quasi-Experimental Study." Global Journal of Health Science 9, no. 11 (2017): 178. http://dx.doi.org/10.5539/gjhs.v9n11p178.

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BACKGROUND: The acetic acid in the form of vinegar has been used for medicinal purposes since ancient times. Acetic acid is reported to be used for medicinal uses at 1-5% concentration. The mechanism behind the regenerative potential of commercial acetic acid has not been fully explored.MATERIALS & METHODS: Twelve Iraqi patients with chronic skin ulceration were admitted and managed at a Dermatology clinic. Patients included men (7) and women (5) of diverse age groups (23-81 years). The aetiology behind the skin ulceration included; diabetic ulcer, decubitus ulcer, and others induced by tr

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Arshad, Sohaib, Fatima Tehreem, Muhammad Rehab khan, Fatima Ahmed, Anand Marya, and Mohmed Isaqali Karobari. "Platelet-Rich Fibrin Used in Regenerative Endodontics and Dentistry: Current Uses, Limitations, and Future Recommendations for Application." International Journal of Dentistry 2021 (December 15, 2021): 1–8. http://dx.doi.org/10.1155/2021/4514598.

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Regenerative endodontics has introduced numerous procedures such as pulp implantation, revascularization, and postnatal stem cell therapy. Revascularization has been successfully implemented clinically nowadays, thus providing dentists with outrageous results. Platelet-rich fibrin (PRF) used either alone or along with bone graft promotes bone growth and vascularization. This matrix promotes migration, cell attachment, and proliferation of osteoblast that leads to bone formation. PRF consists of a packed fibrin complex consisting of leukocytes, cytokines, and glycoproteins such as thrombospondi

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Șerban, Mirela Violeta, Simona-Rebeca Nazarie (Ignat), Sorina Dinescu, et al. "Silk ProteinsEnriched Nanocomposite Hydrogels Based on Modified MMT Clay and Poly(2-hydroxyethyl methacrylate-co-2-acrylamido-2-methylpropane Sulfonic Acid) Display Favorable Properties for Soft Tissue Engineering." Nanomaterials 12, no. 3 (2022): 503. http://dx.doi.org/10.3390/nano12030503.

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Due to their remarkable structures and properties, three-dimensional hydrogels and nanostructured clay particles have been extensively studied and have shown a high potential for tissue engineering as solutions for tissue defects. In this study, four types of 2-hydroxyethyl methacrylate/2-acrylamido-2-methylpropane sulfonic acid/montmorillonite (HEMA/AMPSA/MMT) hydrogels enriched with sericin, and fibroin were prepared and studied in the context of regenerative medicine for soft tissue regenerative medicine. Our aim was to obtain crosslinked hydrogel structures using modified montmorillonite c

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Zhou, Shangming, Zhiping Zhu, Tao Li, and Huo Yang. "The response surface method is used to investigate the optimal corrosion inhibition condition of reclaimed water pipeline." Journal of Physics: Conference Series 2821, no. 1 (2024): 012002. http://dx.doi.org/10.1088/1742-6596/2821/1/012002.

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Abstract In order to solve the problem of corrosion and scaling in the recycled water pipeline of thermal power plan, sodium polarized sodium phosphate and sodium molybdenum acid were selected as comparison experiments, and dynamic experiments were used to simulate recycled water through dynamic experiments. The actual usage situation, through the weight of the test, inspected the corrosion effect of different concentration corrosion doses, and the three-dimensional dynamic model of the regenerative water pipeline corrosion of the regenerative water pipeline at the response surface analysis, a

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Belykh, M. A. "Impact of 4,4’-(propanediamide)Dibenzoate Sodium on Manifestations of Experimental Non-Alcoholic Steatohepatitis." Journal Biomed 17, no. 3 (2021): 95–99. http://dx.doi.org/10.33647/2074-5982-17-3-95-99.

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The impact of a propanedioic acid derivative, 4,4’-(propanediamide)dibenzoate sodium (maloben), on the physiological and histological characteristics of mice line C57BL/6 was studied under 24-week modeled steatohepatitis. It was found that the compound in question exhibits hepatoprotective and regenerative properties, thus being promising for further study as an anti-steatosis agent.

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Martín-del-Campo, Marcela, José G. Sampedro, María Lisseth Flores-Cedillo, Raul Rosales-Ibañez, and Luis Rojo. "Bone Regeneration Induced by Strontium Folate Loaded Biohybrid Scaffolds." Molecules 24, no. 9 (2019): 1660. http://dx.doi.org/10.3390/molecules24091660.

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Nowadays, regenerative medicine has paid special attention to research (in vitro and in vivo) related to bone regeneration, specifically in the treatment of bone fractures or skeletal defects, which is rising worldwide and is continually demanding new developments in the use of stem cells, growth factors, membranes and scaffolds based on novel nanomaterials, and their applications in patients by using advanced tools from molecular biology and tissue engineering. Strontium (Sr) is an element that has been investigated in recent years for its participation in the process of remodeling and bone f

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Agarwal, Vanshika, Ansuiya Warikoo, Pallav Prakash, Pallavi Sharma, Manya Pahwa, and Fiza Alam. "Ocimum Sanctum: A Herbal Agent for Revivification of Periodontal Health." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 2 (2023): 6445–52. http://dx.doi.org/10.37285/ijpsn.2023.16.2.7.

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The increasing awareness of keeping oral hygiene intact and turning minds into natural therapeutic agents has become a point of concern. India, the diversified homeland to sanative herbs which can supplant harmful and delayed consequence-causing chemical substances, is a boon to the nation. Among all the phytotherapeutic essentials, lies a herb known for being all in one, pharmacological miracle - Ocimum sanctum (or commonly referred to as Tulsi). Tulsi has been applied in various arenas of medicine, especially oral medicine. The plant has immense healing potential. The chemicals extracted fro

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