Academic literature on the topic 'Regulated kinase'

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Journal articles on the topic "Regulated kinase"

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Abe, Mark K., Wen-Liang Kuo, Marc B. Hershenson, and Marsha Rich Rosner. "Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth." Molecular and Cellular Biology 19, no. 2 (1999): 1301–12. http://dx.doi.org/10.1128/mcb.19.2.1301.

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ABSTRACT Mitogen-activated protein (MAP) kinases play distinct roles in a variety of cellular signaling pathways and are regulated through multiple mechanisms. In this study, a novel 61-kDa member of the MAP kinase family, termed extracellular signal-regulated kinase 7 (ERK7), has been cloned and characterized. Although it has the signature TEY activation motif of ERK1 and ERK2, ERK7 is not activated by extracellular stimuli that typically activate ERK1 and ERK2 or by common activators of c-Jun N-terminal kinase (JNK) and p38 kinase. Instead, ERK7 has appreciable constitutive activity in serum
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Kinashi, T., JA Escobedo, LT Williams, K. Takatsu, and TA Springer. "Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways." Blood 86, no. 6 (1995): 2086–90. http://dx.doi.org/10.1182/blood.v86.6.2086.bloodjournal8662086.

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Receptor tyrosine kinases are known to be important in growth and differentiation. We have recently found that c-kit, the tyrosine kinase receptor for steel factor, also regulates cell-matrix adhesion. Because Steel factor helps regulate cell migration and localization, this may be an important biologic function. Integrin adhesiveness is regulated within minutes by c-kit. The signaling pathways for tyrosine kinase stimulation of integrin adhesiveness and their relation to pathways that regulate growth and differentiation over much longer time periods remain uncharacterized. We have studied the
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Yan, Lijun, and Richard F. Lamb. "Signalling by amino acid nutrients." Biochemical Society Transactions 39, no. 2 (2011): 443–45. http://dx.doi.org/10.1042/bst0390443.

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It is clear that mTORC1 (mammalian target of rapamycin complex 1) is regulated by the presence of ambient amino acid nutrients. However, the mechanism by which amino acids regulate mTORC1 is still open to question, despite extensive efforts. Our recent work has revealed that PR61ϵ, a B56 family regulatory subunit of PP2A (protein phosphatase 2A), associates with and regulates the activity of MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3), a protein kinase regulated by amino acid sufficiency that acts upstream of mTORC1. In searching for a physiological process regulated by am
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Zhou, Feng-Quan, and William D. Snider. "Intracellular control of developmental and regenerative axon growth." Philosophical Transactions of the Royal Society B: Biological Sciences 361, no. 1473 (2006): 1575–92. http://dx.doi.org/10.1098/rstb.2006.1882.

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Axon growth is a highly regulated process that requires stimulating signals from extracellular factors. The extracellular signals are then transduced to regulate coordinately gene expression and local axon assembly. Growth factors, especially neurotrophins that act via receptor tyrosine kinases, have been heavily studied as extracellular factors that stimulate axon growth. Downstream of receptor tyrosine kinases, recent studies have suggested that phosphatidylinositol-3 kinase (PI3K) regulates local assembly of axonal cytoskeleton, especially microtubules, via glycogen synthase kinase 3β (GSK-
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BISOTTO, Sandra, and Elizabeth D. FIXMAN. "Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor." Biochemical Journal 360, no. 1 (2001): 77–85. http://dx.doi.org/10.1042/bj3600077.

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The multisubstrate docking protein, growth-factor-receptor-bound protein 2-associated binder 1 (Gab1), which is phosphorylated on tyrosine residues following activation of receptor tyrosine kinases and cytokine receptors, regulates cell proliferation, survival and epithelial morphogenesis. Gab1 is also tyrosine phosphorylated following activation of G-protein-coupled receptors (GPCRs) where its function is poorly understood. To elucidate the role of Gab1 in GPCR signalling, we investigated the mechanism by which the type A endothelin-1 (ET-1) GPCR induced tyrosine phosphorylation of Gab1. Tyro
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Roffey, Scott E., and David W. Litchfield. "CK2 Regulation: Perspectives in 2021." Biomedicines 9, no. 10 (2021): 1361. http://dx.doi.org/10.3390/biomedicines9101361.

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The protein kinase CK2 (CK2) family encompasses a small number of acidophilic serine/threonine kinases that phosphorylate substrates involved in numerous biological processes including apoptosis, cell proliferation, and the DNA damage response. CK2 has also been implicated in many human malignancies and other disorders including Alzheimer′s and Parkinson’s diseases, and COVID-19. Interestingly, no single mechanism describes how CK2 is regulated, including activation by external proteins or domains, phosphorylation, or dimerization. Furthermore, the kinase has an elongated activation loop that
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Chung, J., R. H. Chen, and J. Blenis. "Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro." Molecular and Cellular Biology 11, no. 4 (1991): 1868–74. http://dx.doi.org/10.1128/mcb.11.4.1868-1874.1991.

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Protein kinase assays that use recombinant pp90rsk as a substrate were developed in an attempt to identify growth-regulated enzymes responsible for the phosphorylation and activation of pp90rsk S6 phosphotransferase activity. With this assay we have ientified a pp60v-src-, growth factor-, phorbol ester-, and vanadate-regulated serine/threonine protein kinase activity that is not related to two other cofactor-independent, growth-regulated protein kinases, pp70-S6 protein kinase and pp90rsk. The pp90rsk-protein kinase activity (referred to as rsk-kinase) is also not related to cofactor-dependent
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Chung, J., R. H. Chen, and J. Blenis. "Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro." Molecular and Cellular Biology 11, no. 4 (1991): 1868–74. http://dx.doi.org/10.1128/mcb.11.4.1868.

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Protein kinase assays that use recombinant pp90rsk as a substrate were developed in an attempt to identify growth-regulated enzymes responsible for the phosphorylation and activation of pp90rsk S6 phosphotransferase activity. With this assay we have ientified a pp60v-src-, growth factor-, phorbol ester-, and vanadate-regulated serine/threonine protein kinase activity that is not related to two other cofactor-independent, growth-regulated protein kinases, pp70-S6 protein kinase and pp90rsk. The pp90rsk-protein kinase activity (referred to as rsk-kinase) is also not related to cofactor-dependent
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Ha, Jain, Eunjeong Kang, Jihye Seo, and Sayeon Cho. "Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway." International Journal of Molecular Sciences 20, no. 24 (2019): 6157. http://dx.doi.org/10.3390/ijms20246157.

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Protein phosphorylation affects conformational change, interaction, catalytic activity, and subcellular localization of proteins. Because the post-modification of proteins regulates diverse cellular signaling pathways, the precise control of phosphorylation states is essential for maintaining cellular homeostasis. Kinases function as phosphorylating enzymes, and phosphatases dephosphorylate their target substrates, typically in a much shorter time. The c-Jun N-terminal kinase (JNK) signaling pathway, a mitogen-activated protein kinase pathway, is regulated by a cascade of kinases and in turn r
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Moreno, Maria, Assunta Lombardi, Elena Silvestri, et al. "PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling." PPAR Research 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/435689.

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Peroxisome proliferator-activated receptors (PPARs), which are known to regulate lipid homeostasis, are tightly controlled by nutrient availability, and they control nutrient handling. In this paper, we focus on how nutrients control the expression and action of PPARs and how cellular signaling events regulate the action of PPARs in metabolically active tissues (e.g., liver, skeletal muscle, heart, and white adipose tissue). We address the structure and function of the PPARs, and their interaction with other nuclear receptors, including PPAR cross-talk. We further discuss the roles played by d
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Dissertations / Theses on the topic "Regulated kinase"

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Raman, Malavika. "Identification of intracellular signaling pathways regulated by the TAO family of mammalian STE20p kinases." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=163.

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Probst, Brandon Linn. "Identification of substrates and pathways regulated by PAS kinase." Access to abstract only; dissertation is embargoed until after 12/20/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=137.

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Gasser, Jessica Ann. "Serum and Glucocorticoid-Regulated Kinase Signaling in Breast Cancer." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11296.

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Oncogenic activating mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI 3-K), are highly prevalent in breast cancer. The protein kinase Akt is considered to be the primary effector of PIK3CA, though the mechanisms by which PI 3-K mediates tumorigenic signals in an Akt-independent manner remain obscure. My studies show that the serum and glucocorticoid-regulated kinases (SGKs) can function as effectors of PI 3-kinase and transduce signals to phenotypes associated with malignancy. We show that SGK3 is amplified in breast cancer and identify the mechani
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Prescott, Gerald Robert. "The role of the kinase, Akt/PKBin regulated exocytosis." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479062.

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NADAL, WOLLBOLD FLORENCE. "Activation et regulation des map kinases extracellular signal-regulated kinase 2 et c-jun nh2-terminal kinase 1 dans les plaquettes humaines." Paris 7, 2000. http://www.theses.fr/2000PA077163.

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Les map kinases sont des serine/threonine kinases regroupees en trois familles : les extracellular signal-regulated kinases (erks), les c-jun nh2-terminal kinases (jnks) et les p38 m a p k s. Principalement activees par les recepteurs a activite tyrosine kinase, les recepteurs couples aux proteines g heterotrimeriques et les integrines, elles jouent un role important dans la proliferation, la differenciation, la migration et l'apoptose. Si l'activation, la regulation, et le role des map kinases sont tres etudiees dans les cellules proliferatrices, tres peu de travaux sont realises dans les cel
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Nekhoroshkova, Elena. "A-RAF kinase functions in ARF6 regulated endocytic membrane traffic." kostenfrei, 2009. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-44566.

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Wu, Jheng-Yu. "Regulation of Extracellular Signal-Regulated Kinase by Histone Deacetylase 6." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6985.

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Extracellular signal-regulated kinases 1/2 (ERK1/2) are important kinases regulating cell proliferation and cell migration, and have been established as therapeutic targets for cancer treatment. Previously, we found that ERK1 phosphorylates histone deacetylase 6 (HDAC6) to regulate its enzymatic activity. However, whether HDAC6 reciprocally modulates ERK1 activity is unknown. Here, we have discovered that ERK1/2 are acetylated proteins and shown that HDAC6 manipulates ERK1’s kinase activity via deacetylation. We demonstrated that both ERK1 and ERK2 interact with HDAC6 physically. We showed tha
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Peters, Marco. "The calcium-calmodulin regulated Kinase cascade in learning and memory." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406738.

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Dan, Yuzhen 1992. "Signaling networks regulated by the kinase p38α in cancer cell homeostasis". Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673710.

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p38α (encoded by MAPK14) is a major regulator of cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates various substrates both in the cytoplasm and nucleus, allowing this pathway to regulate a wide variety of cellular processes, including cell proliferation, differentiation, or survival. Given the plethora of functions that can be controlled by p38α, we performed proteomic and phosphoproteomic analysis to study the signaling networks regulated by p38α during cancer cell homeostasis. Our study identifies 35 proteins and 114 phos
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Kulaberoglu, Y. "The functional characterisation of MOB1-regulated Hippo core cassette kinase signalling." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1537606/.

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The Hippo tumour suppressor pathway regulates tissue growth by co-ordinating cell death, proliferation and differentiation. The central Hippo core cassette consists of MST1/2, LATS1/2, NDR1/2 and MOB1, with recent studies of MOB1 knockout mice indicating MOB1 functions as the central hub of Hippo signalling. However, it has remained unknown which interactions of MOB1 with the Hippo core cassette kinases MST1/2, LATS1/2 and NDR1/2 are required for normal life and tumour suppression. Therefore, my PhD project focused on deciphering the complex protein-protein interactions of MOB1 with MST1/2, LA
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Books on the topic "Regulated kinase"

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Matsushima, Danielle Erina. 3-Phosphoinositide-dependent kinase-1 (PDK1)-mediated signaling regulates hematopoietic stem cell (HSC) quiesence by governing the oxidative response. [publisher not identified], 2016.

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Chander, Ashok Coil. Integrin-Linked Kinase, ECM Composition, and Substrate Rigidity Regulate Focal Adhesion - Actin Coupling, Modulating Survival, Proliferation and Migration: Towards a Biophysical Cancer Biomarker. [publisher not identified], 2012.

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1728-1784, Gentleman Francis, ed. Bell's edition of Shakespeare's plays: As they are now performed at the Theatres Royal in London, regulated from the prompt books of each house... [and the poems]; with notes critical and illustrative [an essay on oratory and the life of Shakespeare]. Pergamon, 1985.

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Friedman, Adam Amiel. Genomic dissection of receptor tyrosine kinase activation of extracellular signal-regulated kinase in Drosophila. 2007.

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Tessier, Maude. Determination of the mechanism of activation and the physiological functions of serum and glucocorticoid-regulated kinase-3. 2006.

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Holappa, Lynn D. Identification and expression of a wheat protein kinase gene regulated by abscisic acid and by environmental stress. 1994.

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Alcorn, Melissa Jean. Induction of inerleukin-8 by adenovirus serotype 7 via activation of extracellular-regulated kinase 1/2 and the role of the fiber attachment receptor. [s.n.], 2002.

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Patel, Darpini H., and Bhuvan P. Raval. A Role of Tec : A non Receptor Tyrosine Kinase as Apoptotic Regulator: Enzyme in Programmed Cell Death. LAP Lambert Academic Publishing, 2012.

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Vitamin D3 Analogues with Low Vitamin D Receptor Binding Affinity Regulate Chondrocyte Proliferation, Proteoglycan Synthesis, and Protein Kinase C Activity. Storming Media, 1997.

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Menon, Deepa U. Autism and Intellectual Disabilities. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0053.

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PTEN (phosphatase and tensin homologue) on chromosome 10q23.3 is a tumor suppressor gene that encodes for a dual specificity phosphatase that regulates the phosphatidylinositol 3- kinase pathway and has an important role in brain development by affecting neuronal survival, neurite outgrowth, synaptic plasticity, and learning memory. Germline mutations of the PTEN gene have been implicated in a group of related tumor syndromes with autosomal dominant inheritance and variable expression and include the Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Juvenile Polyposis s
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Book chapters on the topic "Regulated kinase"

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Miki, Toru, Randa Hilal-Dandan, Laurence L. Brunton, et al. "Extracellular Regulated Kinase 1 and 2." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100422.

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Nakamura, Kazuhiro, and Gary L. Johnson. "Activity Assays for Extracellular Signal-Regulated Kinase 5." In MAP Kinase Signaling Protocols. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-795-2_5.

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Orellana, Daniel, Ilaria Morella, Marzia Indrigo, Alessandro Papale, and Riccardo Brambilla. "The Extracellular Signal-Regulated Kinase (ERK) Cascade in Neuronal Cell Signaling." In Protein Kinase Technologies. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-824-5_8.

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Gewies, Andreas, Jürgen Ruland, Alexey Kotlyarov, et al. "Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Kinases 1/2 (MEK1/2)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100810.

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Gewies, Andreas, Jürgen Ruland, Alexey Kotlyarov, et al. "MEK5/ERK5: Mitogen-Activated Protein Kinase 5/Extracellular Signal-Regulated Kinase 5." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100786.

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Moore, P. A., A. J. E. Bettany, and A. J. P. Brown. "The Yeast Pyruvate Kinase Gene is Regulated at Multiple Levels." In Post-Transcriptional Control of Gene Expression. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75139-4_39.

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Pascual-Castroviejo, Ignacio, and Martino Ruggieri. "Costello Syndrome and the Ras-Extracellular Signal Regulated Kinase (ERK) Pathway." In Neurocutaneous Disorders Phakomatoses and Hamartoneoplastic Syndromes. Springer Vienna, 2008. http://dx.doi.org/10.1007/978-3-211-69500-5_66.

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Niswender, C. M., and G. S. McKnight. "Transgenic Models for the Study of Protein Kinase A-Regulated Signal Transduction." In Transgenic Models in Pharmacology. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18934-0_5.

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Zhang, Ye, Tada-aki Kudo, Yunchia Ku, et al. "The role of extracellular signal-regulated kinase 5 signaling pathway in neurons." In Interface Oral Health Science 2009. Springer Japan, 2010. http://dx.doi.org/10.1007/978-4-431-99644-6_47.

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Kim, Hyun Jae, In Soon Kang, and Chaekyun Kim. "Taurine Chloramine Inhibits Leukocyte Migration by Suppressing Actin Polymerization and Extracellular Signal-Regulated Kinase." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-93337-1_5.

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Conference papers on the topic "Regulated kinase"

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Wang, L., P. Chitano, P. D. Paré, and C. Y. Seow. "Is Rho-Kinase Expression Up-Regulated in Asthmatic Airway Smooth Muscle?" In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2846.

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Shukla, Arti, Jill Miller, Christopher Cason, et al. "Abstract 4315: Extracellular signal regulated kinase 5 inpathogenesis of malignant mesothelioma." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4315.

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Kosoff, Rachelle E., and Jonathan Chernoff. "Abstract A15: Megakaryocyte differentiation is regulated by p21-activated kinase 2." In Abstracts: AACR Special Conference on RAS Oncogenes: From Biology to Therapy; February 24-27, 2014; Lake Buena Vista, FL. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1557-3125.rasonc14-a15.

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Watson, CM, D. Kipgen, C. Orange, et al. "Role of extracellular signal-regulated kinase 5 (ERK5) in human breast cancer." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-4042.

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Han, Yong, Yan Li, Yonghua Wang, Hua Fang, and Shuwei Zhang. "Dynamic Analysis of Feedback Loops in Extra-Cellular Signal Regulated Kinase Signal Network." In 2009 WRI World Congress on Computer Science and Information Engineering. IEEE, 2009. http://dx.doi.org/10.1109/csie.2009.142.

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Kim, Seung-Min, Cheol-Jung Lee, Sun-Mi Yoo, Seon-Yeon Cho, Juhee Park, and Yong-Yeon Cho. "Abstract 3537: FBXW7-mediated extracellular signal-regulated kinase 3 stability in cancer development." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3537.

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Chu, Tony LH, Jennifer Won, Oksana Nemirovsky, Abbas Fotovati, Torsten Nielsen, and Christopher A. Maxwell. "Abstract A61: Cell cycle regulated centrosome orientation during directed migration requires Aurora Kinase A." In Abstracts: AACR Special Conference: Advances in Breast Cancer; October 17-20, 2015; Bellevue, WA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3125.advbc15-a61.

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Newton, Robert, Elizabeth M. King, Wei Gong, Christopher F. Rider, and Neil S. Holden. "Induction Of Mitogen-Activated Protein Kinase Phosphatase (MKP) 1 By Glucocorticoids Inhibits Extracellular-Regulated Kinases (ERKs) To Suppress GM-CSF Synthesis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4948.

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Wong, R., H. El-Said, S. Hegde, K. Bush, and D. Lesser. "MEK-in Chylothorax Go Away: RAS/mitogen-activated Protein Kinase-extracellular Signal-regulated Kinase Inhibitor (MEK-in) Treatment of Diffuse Pulmonary Lymphatic Disease." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1904.

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Mancuso, Peter, Martin G. Myers, Jr., Deepti Goel, Carlos Henrique Serezani, and Marc Peters-Golden. "Ablation Of Leptin Receptor Mediated Extracellular Regulated Kinase Activation Impairs Host Defense Against Bacterial Pneumonia." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6109.

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Reports on the topic "Regulated kinase"

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Tierney, L. A., C. Bloomfield, and N. F. Johnson. Expression of a TGF-{beta} regulated cyclin-dependent kinase inhibitor in normal and immortalized airway epithelial cells. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/381389.

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Tyner, Angela L. A Small Scale Proteomics Approach for Identifying Proteins Regulated by the Breast Tumor Kinase BRK Signal Transduction Pathway. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada406106.

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Yu, Mei, Pengyu Wang, Binbin Li, et al. NRSF Negatively Regulates Microglial Pro-Inflammatory Activation. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.20.02.

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Microglial activation contributes to neurological disorders like Parkinson’s disease (PD), and modulating this activation is a potential therapeutic approach. The neuron-restrictive silencer factor (NRSF) functions as a negative regulator of gene transcription through epigenetic modifications. While previous research has primarily examined the role of NRSF in neuronal differentiation and injury, emerging evidence indicates that NRSF also plays a significant role in maintaining the phenotype of glial cells. In this study, we explored the role and underlying mechanisms of NRSF in lipopolysacchar
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Fromm, Hillel, Paul Michael Hasegawa, and Aaron Fait. Calcium-regulated Transcription Factors Mediating Carbon Metabolism in Response to Drought. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699847.bard.

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Original objectives: The long-term goal of the proposed research is to elucidate the transcription factors, genes and metabolic networks involved in carbon metabolism and partitioning in response to water deficit. The proposed research focuses on the GTLcalcium/calmodulinbindingTFs and the gene and metabolic networks modulated by these TFs in Arabidopsis thaliana. The specific objectives are as follows. Objective-1 (USA): Physiological analyses of GTL1 loss- and gain-of-function plants under water sufficient and drought stress conditions Objective 2 (USA / Israel-TAU): Characterizion of GTL ta
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Droby, Samir, Michael Wisniewski, Ron Porat, and Dumitru Macarisin. Role of Reactive Oxygen Species (ROS) in Tritrophic Interactions in Postharvest Biocontrol Systems. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7594390.bard.

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To elucidate the role of ROS in the tri-trophic interactions in postharvest biocontrol systems a detailed molecular and biochemical investigation was undertaken. The application of the yeast biocontrol agent Metschnikowia fructicola, microarray analysis was performed on grapefruit surface wounds using an Affymetrix Citrus GeneChip. the data indicated that 1007 putative unigenes showed significant expression changes following wounding and yeast application relative to wounded controls. The expression of the genes encoding Respiratory burst oxidase (Rbo), mitogen-activated protein kinase (MAPK)
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Dickman, Martin B., and Oded Yarden. Role of Phosphorylation in Fungal Spore Germination. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568761.bard.

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Spore germination is a common and fundamental event in fungal development and in many instances an essential phase of fungal infection and dissemination. Spore germination is also critical for hyperparasites to function as biocontrol agents as well as in fermentation proceses. Our common objective is to understand the mechanisms which regulated spore germination and identify factors involved in pathogenicity related prepenetration development. Our approach is to exploit the overall similarity among filamentous fungi using both a plant pathogen (Colletotricum trifolii) and a model system that i
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Dickman, Martin B., and Oded Yarden. Phosphorylative Transduction of Developmental and Pathogenicity-Related Cues in Sclerotinia Sclerotiorum. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7586472.bard.

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Sclerotinia sclerotiorum (Lib.) de Bary is among the world's most successful and omnivorous fungal plant pathogens. Included in the more than 400 species of plants reported as hosts to this fungus are canola, alfalfa, soybean, sunflower, dry bean, and potato. The general inability to develop resistant germplasm with these economically important crops to this pathogen has focused attention on the need for a more detailed examination of the pathogenic determinants involved in disease development. This proposal involved experiments that examined the involvement of protein phosphorylation during m
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Thongchul, Nuttha. Development of itaconic acid production technology for bioplastic using immobilized Aspergillus terreus on natural fiber in the static bed bioreactor. Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.99.

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Aspergillus terreus was reported as the promising fungal strain for itaconic acid; however, the commercial production suffers from the low yield. Low production yield was claimed as the result of completing TCA cycle towards biomass synthesis while under limiting phosphate and nitrogen, TCA cycle was somewhat shunted and consequently the metabolite fluxes move towards itaconic acid production route. By regulating enzymes in TCA cycle, it is believed that itaconic acid production can be improved. One of the key responsible enzymes involved in itaconic acid production was triggered in this study
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Heidenreich, Kim A. Protein Kinase Pathways That Regulate Neuronal Survival and Death. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada429843.

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Heidenreich, Kim A. Protein Kinase Pathways that Regulate Neuronal Survival and Death. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada419485.

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