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Dissertations / Theses on the topic 'Regulatory role'

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Published: 30 May 2022
Last updated: 31 July 2025

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1

Nica, Alexandra Cristina. "Regulatory variation and its role in disease." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609208.

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2

Zhang, Yuyan. "Role of Regulatory Focus in Job Attraction." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1447257141.

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3

Petkova, Zhivka Yohanova. "Optimizing Training Effectiveness: The Role of Regulatory Fit." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1320673768.

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4

Zaidi, Irfan ul Hassan. "Role of t-regulatory cells in HIV_2 infection." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542452.

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5

Yang, Min, and 杨敏. "Role of regulatory B cells in autoimmune disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079832.

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Although B cells are well-known for their functions in antibody production and antigen presentation, certain B cell subsets have been recently identified as regulatory B cells to modulate immune responses through cytokine production. However, the microenvironmental factors involved in the induction of regulatory B cells remain largely uncharacterized. B cell-activating factor (BAFF), a member of TNF family cytokines produced by myeloid cells, is a key regulator for B cell maturation and function. However, it remains unknown whether BAFF plays a role in modulating the generation of regulatory
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6

Pinho, Bárbara Marina da Silva. "Regulatory affairs role in a multinational pharmaceutical company." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/12967.

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Mestrado em Biomedicina Farmacêutica<br>The present monograph intends to present a Regulatory Affairs department at a Multinational Pharmaceutical Company, as well as the role of the professionals working in that department. The experience which led to this monograph occurred after the conclusion of the curricular part of the Masters in Pharmaceutical Medicine, and was an opportunity to apply all the knowledge previously acquired and to develop new technical and personal skills. After the contextualisation of this document, the first chapter of this monograph introduce the Regulatory Affairs P
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7

Mori, L. "REGULATORY ROLE OF MICRORNAS ON INFLAMMATORY SIGNALING PATHWAYS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/168371.

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Innate immunity is the primary defense mechanism that recognizes and respond to invading infectious microbes or their components, known as pathogen-associated molecular patterns (PAMPs), or to danger signals that comes from self components, known as danger-associated molecular patterns (DAMPs). These molecules are recognized in our body by the so called pattern recognition receptors (PRRs), whose activation quickly gives rise to an important cascade of events known as acute inflammatory response. Within few hours, pro-inflammatory cytokines, such as TNFα, IL-1β and IL6, and chemokine, such as
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8

Aspiras, Olivia G. "Regulatory Fit of Social Comparison Information: Similarity versus Dissimilarity to Health Role Models." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1481120129818667.

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9

Owens, Katherine Anne. "Environmental water transactions under regulatory capitalism: The role of law." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13756.

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Since the late 20th century, governments have promoted the acquisition of water rights in order to recover water for the environment. The use of water transfer mechanisms for this purpose devolves important water use decisions to individual water users, and enables governments to achieve wider public goals in relation to the management of water scarcity without resorting to bureaucratic reallocation. However, governments retain an important oversight and coordination role within these regimes, and the result has been dense systems of regulation, involving legal interactions between a range o
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10

Koutrolos, Michail. "Role of regulatory T cells in experimental autoimmune encephalomyelitis." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-161896.

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11

Hay, Deborah. "The role of regulatory elements in alpha globin transcription." Thesis, University of Oxford, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665159.

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Understanding the mechanisms of transcriptional control by cis-acting regulatory elements is one of the major goals in current molecular biology. Estimates of enhancer numbers in mammalian genomes extend to hundreds of thousands, outnumbering genes by an order of magnitude or more. Yet current high throughput methods for enhancer identification give only indirect insights into their function, and are unable to demonstrate heterogeneity, redundancy, or cooperativity between regulatory elements. The a-globin locus has been extensively characterized with regard to transcriptional output, chromati
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12

Carvalho, Thiago Lopes. "The role of regulatory CD4 T cells in inflammation." Doctoral thesis, Porto : Edição do Autor, 2003. http://hdl.handle.net/10216/64576.

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13

Carvalho, Thiago Lopes. "The role of regulatory CD4 T cells in inflammation." Tese, Porto : Edição do Autor, 2003. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000090835.

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14

Nikitin, Artemii. "Role of nuclear receptor RORα in regulatory T cells". Thesis, Université de Lille (2018-2021), 2019. http://www.theses.fr/2019LILUS073.

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Les facteurs de transcription de la superfamille des récepteurs nucléaires jouent de multiples rôles dans le développement et la fonction des lymphocytes T régulateurs (TREG). Les TREG sont des cellules régulatrices/suppressives qui contrôlent les réponses d’autres types cellulaires et l’homéostasie locale des tissus.Comme les TREG sont actives au sein de divers organes, tant à l’homéostasie qu’en conditions inflammatoires,ils doivent répondre à la fois aux contexte local au sein du tissus et à un environnement immunologiquement agressif tout en préservant leurs propriétés tolérogéniques au co
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15

Tam, Wing Yin Leona. "Goal pursuit is more than planning: the moderating role of regulatory fit." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4327.

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Research indicates that planning helps consumers in their goal pursuit, but little is known about how and when such beneficial effects change with regulatory fit – fit between consumers’ regulatory orientation and goal pursuit means. Results of three studies show that 1) the benefits of forming implementation intentions, or planning details such as when, where, how, and how long to perform goal-directed actions and attain consumer goals are stronger in regulatory nonfit situations (study 1), and 2) implementation intentions can be viewed as goal pursuit means and be part of the regul
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16

Yin, Weiwei. "The role and regulatory mechanisms of nox1 in vascular systems." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44833.

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As an important endogenous source of reactive oxygen species (ROS), NADPH oxidase 1 (Nox1) has received tremendous attention in the past few decades. It has been identified to play a key role as the initial "kindle," whose activation is crucial for amplifying ROS production through several propagation mechanisms in the vascular system. As a consequence, Nox1 has been implicated in the initiation and genesis of many cardiovascular diseases and has therefore been the subject of detailed investigations. The literature on experimental studies of the Nox1 system is extensive. Numerous investig
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17

Varikuti, Sanjay. "Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis." TopSCHOLAR®, 2009. http://digitalcommons.wku.edu/theses/113.

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Toxoplasmosis is an important cause of congenital disease, and it is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome. The need for a reliable experimental model of this infection is crucial not only for achieving a better understanding of the patho-physiology of the disease, but also for developing better methods for evaluating new therapeutic regimens. The purpose of the present study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with Toxoplasma gondii. T regulatory (Treg) cells have been shown to play an
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18

Petrov, P. (Petar). "Leukocyte protein Trojan, as a candidate for apoptotic regulatory role." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526210346.

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Abstract Trojan is a novel leukocyte-specific protein cloned from chicken (Gallus gallus) embryonic thymocytes. The molecule is a type I transmembrane protein with an extracellular CCP domain followed by two FN3 domains. Its cytoplasmic tail is predicted to possess a MAPK docking and a PKA phosphorylation site. Trojan displays differential expression on developing thymocyte subpopulations. It is high on CD4 and CD8 double negative, and CD4 or CD8 single positive cells, but diminishes from the surface of selection-undergoing CD4 and CD8 double positive cells. This expression pattern is similar
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19

Yeoh, Joyce Siew Gaik. "Regulatory role of fibroblast growth factors on hematopoietic stem cells." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/299000842.

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20

Chen, Guohua 1966. "A potential role of iron-regulatory proteins in tumor growth /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97925.

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Iron is indispensable for cell proliferation and growth, but it is potentially toxic when present in excess. Two homologous iron regulatory proteins (IRP1 and IRP2) control cellular iron homeostasis by binding to iron-responsive elements (IREs) and post-transcriptionally coordinating the expression of transferrin receptor 1 (TfR1) and ferritin. We have previously reported that overexpression of IRP1C437S, a constitutive IRP1 mutant, inhibits H1299 human lung cancer cell growth in vitro. In current study, we investigated the potential role of IRPs in tumor growth in vivo by the injection of H12
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21

Antunes, I. L. "Role and specificity of regulatory T cells during retroviral infection." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/16270/.

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During chronic viral infection of the hematopoietic system, both virus-mediated and immune-mediated effects may cause bone marrow dysfunction leading to cytopenias. To study the pathological consequences of the T helper response to unresolving chronic infection, a system was developed using infection of immunodeficient mice with Friend virus (FV). FV is a murine retroviral complex, which causes non-cytopathic persistent infection of hematopoietic cells. The results obtained suggested that unregulated CD4+ T cell response to FV causes bone marrow pathology and anaemia. Regulatory T (Treg) cells
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22

Goina, Elisa. "Role and mechanism of action of exonic splicing regulatory sequences." Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494610.

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Exonic mutations can result in altered protein function by affecting exon recognition during splicing. To understand this mechanism I have extensively evaluated the exonic regulatory elements affected by the disease G to T mutation at position +6 of BRCAl exon 18. This substitution induces the exclusion of the exon and it has been suggested that it disrupts an ASF/SF2-dependent enhancer. Using a pulldown assay with an internal standard, I show that WT and T6 sequences bind ASF/SF2 with similar efficiency, which is significantly lower compared to the binding to a typical enhancer derived from t
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23

Kendal, Adrian R. "The role of FOXP3+ regulatory T-cells in transplant tolerance." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558327.

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A major conceptual shift in immunology has been the recent discovery of regulatory T- cells (Treg), of which C04+Foxp3+ cells are already known to be essential to self- tolerance. Their role in transplant tolerance remains unproven due to the absence of a natural cell surface marker by which they can be manipulated in vivo. A transgenic B6.Foxp3hCD2 mouse was created to express an artificial GPI-anchored human C02/ C052 surface fusion protein under the control of the Foxp3 promoter. Monoclonal antibodies directed against the human C02 and human C052 were used in B6.Foxp3hCD2 mice to isolate an
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24

Stanger, Nicholas D. "The regulatory role of emotion in antisocial behaviour in sport." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3563/.

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This thesis examined the regulatory role of emotion in antisocial behaviour using Bandura’s (1991) social cognitive theory of moral thought and action as a framework. In Chapter 2, moral disengagement was associated with reduced, and empathy with increased, negative affective reactions to unpleasant images depicting players hurt or mistreated. In Chapter 3, an initial study yielded a positive link between moral disengagement and antisocial behaviour which was partially mediated by anticipated guilt. In a second study, manipulating attribution of blame (mechanism of moral disengagement) led to
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25

Penicud, K. "The role of ATM regulatory proteins in DNA damage signalling." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1360343/.

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The DNA damage activated checkpoint kinase ATM is mutated in ataxia telangiectasia, which is characterised by cancer predisposition and neural degeneration. After ionising radiation (IR) ATM signalling proceeds via interaction with Nijmegen breakage syndrome 1 (NBS1). Conversely, ATM INteractor (ATMIN) is required for ATM activation after hypotonic shock. Full ATM activation also requires concomitant chromatin modifications, including histone H4 acetylation at K16 (H4K16Ac) by Tip60. However, the molecular mechanisms underpinning ATM pathway choice and physiological stimuli for ATMIN dependent
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26

Knowles, Felicity. "The regulatory role of MtrA and NsrR in Streptomyces coelicolor." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/53367/.

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Streptomyces coelicolor inhabits a harsh soil environment, which it must adapt and respond to; therefore how S. coelicolor senses and responds to its environment is of the utmost importance. This project addresses two types of regulation system: the three-component system MtrAB-LpqB and the nitrite-sensitive repressor NsrR. Previous work involving the response regulator MtrA has resulted in the hypothesis that MtrA regulates cell division within actinomycetes. However the role of MtrAB-LpqB within S. coelicolor has not been investigated. Therefore it is important to establish whether cell divi
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27

Cho, Soo Hyun. "Role of Saving Goals in Savings Behavior: Regulatory Focus Approach." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259643705.

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28

Wittkorn, Erika L. "Role of Growth Regulatory Pathways in Eye Development and Differentiation." University of Dayton / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398812631.

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29

Navarro, Lorena. "The role of interferon regulatory factor-3 in innate immunity /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3055794.

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30

Gorman, C. Allen, E. A. Ingalls, A. L. E. Thomas, and John P. Meriac. "Leadership and Work Outcomes: The Mediating Role of Regulatory Focus." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/431.

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31

Campbell, Stuart Gaylon. "The role of regulatory light chain phosphorylation in left ventricular function." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3398511.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed May 5, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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32

Jain, Payal 1986. "Dual regulatory role of Polycomblike-3 (PCL3/PHF19) in prostate cancer." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/385438.

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Polycomblike proteins (PCLs) have been shown to regulate Polycomb Repressive Complex 2 (PRC2) by enhancing its catalytic activity and guiding PRC2 to its target genes in embryonic stem cells. However, little is known about the role of PCL proteins in cancer. Here, we describe the role of Polycomblike-3 (PCL3/PHF19) in prostate epithelial cells and prostate cancer. PHF19 maintains the prostate epithelial cells in undifferentiated state and has a multifaceted role in Prostate Cancer. PHF19 is required for cell growth and proliferation of prostate cancer cells but its downregulation confers a swi
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33

Joshi, Nimitray. "Unraveling the role of small regulatory RNAs (sRNAs) in Clostridium difficile." Thesis, University of Nottingham, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716674.

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Clostridium difficile is an opportunistic human pathogen capable of causing a spectrum of diseases ranging from relatively mild antibiotic-associated diarrhoea to severe and life-threatening conditions such as pseudomembranous colitis. Despite its medical importance, comparatively little is known about the regulatory processes that take place in response to environmental changes or to maintain and co-ordinate housekeeping functions. Over the last couple of years, it has become apparent that small RNAs (sRNAs) are playing important regulatory roles in bacteria. Utilizing RNA sequencing (RNA-Seq
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34

Hougardy, Jean-Michel. "Role of regulatory T cells in the pathogenesis of human tuberculosis." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210370.

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Globalement, un tiers de la population mondiale est infectée par Mycobacterium tuberculosis, l'agent infectieux de la tuberculose (TB). Fort heureusement, seuls 5 à 10 % des individus infectés développent un jour une TB active. Les individus non malades restent cependant infectés à vie, on parle d'infection latente. Chaque année, 8-10 millions nouveaux cas de tuberculose active sont recensés et M. tuberculosis est responsable de 1,5 à 2 millions de décès. Depuis plus d'une décennie, M. tuberculosis s'est étroitement associé à l'infection par le virus de l'immunodéficience humaine. Cette allian
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35

Wang, Zhili. "Role of regulatory peptides in the control of islet hormone secretion." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294844.

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36

Kulkarni, Rohit N. "Role of regulatory peptides in the control of #beta#-cell function." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388123.

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37

Amorim, Garcia da Rosa Catarina Alexandre. "The role of regulatory T cells in the prevention of autoimmunity." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312209.

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38

Sassano, Emily. "Role of regulatory T cells in in vitro human culture systems." Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1046.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Burnett College of Biomedical Sciences<br>Molecular and Microbiology
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39

Paredes-Esquivel, Ursula. "The role of cis regulatory domains in behaviour : an evolutionary approach." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479081.

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40

Atorough, Peter. "Consumer behaviour in online shopping : understanding the role of regulatory focus." Thesis, Robert Gordon University, 2013. http://hdl.handle.net/10059/916.

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The behaviour of consumers on the Internet is increasingly a focus of marketing research. In particular, consumers’ behaviour in online shopping, from adoption motivation to post-usage behaviour, has become a major focus of research in the field of marketing, especially within consumer behaviour. Yet it has been acknowledged that while aspects such as adoption and usage motivation are now better understood, there are many questions that remain unanswered, and this warrants continued research effort. In line with the above, this research addresses an issue in online consumer behaviour that is c
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41

Besneux, Matthieu. "Elucidating the role of regulatory T cells in colorectal cancer progression." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/84333/.

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Antigens (Ags) expressed by cancer cells can be specifically recognised by T cells contributing to anti-tumour immunity. For this reason, tumour Ag-specific T helper type 1 (Th1) cells can be detected in cancers and their infiltration is predictive of a prolonged disease-free survival. However, their activity is suppressed by T cells with inhibitory functions i.e. regulatory T cells (Tregs). High infiltration of tumours by these cells often correlates with poor survival. It is therefore crucial to understand their activity. Since Th1 and Treg cells are activated after Ag recognition, it is pla
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42

Colantonio, Jessica Russell. "The role of GAS11 and the dynein regulatory complex in vertebrates." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1495958921&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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43

Dang, Oanh Jenny. "Interferon regulatory factor 3 and its role in the host response /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112824.

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44

Pedro, Roig Laia. "GlnK regulatory proteins and their role in Haloferax mediterranei nitrogen metabolism." Doctoral thesis, Universidad de Alicante, 2012. http://hdl.handle.net/10045/27319.

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45

PULVIRENTI, NADIA. "ROLE OF EOMES+ TYPE 1 REGULATORY T-CELLS IN MULTIPLE SCLEROSIS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/393993.

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La sclerosi multipla (SM) è una malattia degenerativa autoimmune del Sistema Nervoso Centrale (SNC), in cui cellule T CD4 autoreattive attaccano la mielina dei neuroni causando danni al SNC. La SM è anche associata all’infezione del virus Epstein-Barr (EBV), ma il ruolo dei virus nella progressione della SM è dibattuto. Le risposte di cellule T autoreattive e anti-virali sono controllate da popolazioni diverse di cellule T regolatorie, quali le Treg FOXP3+ e le cellule T regolatorie di tipo 1 (Tr1). Entrambe le polazioni sono coinvolte nella SM, ma il ruolo delle cellule Tr1 nella SM in vivo è
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46

Amet, Lorene Eve Aurelie. "The role of subcellular localisation of the HIV-1 Tat protein in viral gene expression." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294272.

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47

Batie, Michael. "Role of chromatin structure and JmjC histone demethylases in the response to hypoxia." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/ce1fbbd7-d3be-49c2-a89e-46b739236887.

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In response to low oxygen (hypoxia), cells have evolved sophisticated gene expression programmes for survival and adaption. How the chromatin state coordinates these changes remains largely unknown. Global histone methylation changes occur in response to hypoxia, however, temporal dynamics of histone methylation changes and how they correlate with hypoxia induced gene transcription changes is ill defined. The Jumonji C (Jmjc) histone demethylases are oxygen dependent enzymes and represent a potential link between chromatin structure and oxygen sensing. Many of these enzymes are differentially
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48

Keegan, Sandra. "Legitimacy in the EU single market : the role of normative regulatory governance." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/7808.

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The thesis examines European legitimacy and regulatory governance. The research analyzes the link between regulatory governance and legitimacy in EU regulation and evaluates whether governance tools in the form of qualitative administrative criteria can contribute to European regulatory legitimacy. Governance here refers to the exercise of delegated regulatory powers by the European Commission. The question of whether the adoption of qualitative regulatory governance practices can enhance the supranational regulatory legitimacy of the European Commission has been underexamined in the literatur
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49

Uribesalgo, Micàs Iris. "Regulatory mechanisms of c-Myc and their role in Acute Myeloid Leukemia." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/31972.

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The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms restrain the oncogenic activity of c-Myc and its impact on cell differentiation. In the first half, we report that PML promotes destabilization of c-Myc protein and re-activation of c-Myc-repressed target genes. The consequent re-expression of the cell cycle inhibitor CDKN1A/p21 mediates differentiation of leukemic cells. In the second half of the thesis we identified a novel mechanism of gene r
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50

Walz, Daryl E. "The role of voluntary non-regulatory initiatives in managing greenhouse gas emissions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0002/MQ42320.pdf.

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