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Dissertations / Theses on the topic 'Renal toxicity'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Magnusson, Emma. "Ouabain Toxicity -Selectivity Towards Renal Cancer Cells." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278574.

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Ouabain and other cardiotonic steroids are known to inhibit Na + ,K + -ATPase (NKA), theion pump responsible for the ionic gradient across the plasma membrane. These steroidsdisplay a selective toxicity towards several tumour cells in comparison to primary humancells, however, the mechanism behind this is not yet understood. Here, we examined theouabain toxicity in renal epithelial cells, proximal tubular cells (PTCs) of different origin. Weinvestigated the relative cytotoxicity in cancer cells (A-498) and papilloma virus-transformedPTCs (HK-2) as well as to primary human PTCs (hPTC) to valida

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2

Old, Sally Louise. "Focal lesions in toxicity studies : methods and models." Thesis, De Montfort University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391200.

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3

Thanh, Nguyen Thi Kim. "Renal lipid changes in response to chemical insults." Thesis, University of East London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246194.

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4

Sword, Corinna Jane. "An in vitro study of aminoglycoside toxicity using established renal cell-lines." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244557.

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5

Morley, Timothy James. "Mechanisms of renal glomerular toxicity of an N-hydroxyurea 5-lipoxygenase inhibitor." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394534.

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The N-hydroxyurea derivative, ((<I>E</I>)-<I>N</I>-{3-[3-(4-fluorophenoxy) phenyl]-1-(<I>R,S</I>)-methylprop-2-enyl}-<I>N</I>-hydroxyurea), (70C), was being developed as a 5-lipoxygenase inhibitor for the treatment of asthma and was found cause severe glomerulopathy in the rat (Read <I>et al</I>, 1995). The lesion appeared to be of greater severity in female rats compared with male rats. The earliest changes detected in the kidney by transmission electron microscopy were noted in the glomeruli, in which the visceral cells appeared enlarged and showed varying degrees of foot process loss. In th

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6

McGoldrick, Trevor A. "C-S lyase-mediated toxicity in primary cultures of proximal tubular cells." Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602010.

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Halogenated alkenes are a group of commercially important chemicals. For example tetrafluoroethylene is the monomer used for the production of poly- tetrafluoroethylene, hexachloro-1:3-butadiene is a by-product from the manufacture of chlorinated solvents and perchloroethylene is widely used as a dry cleaning agent. Due to possible exposure to haloalkenes and the nephrotoxicity observed in animal studies, concern has been expressed for the potential of these compounds to cause toxicity to man. Animal studies have shown that these compounds undergo inter-organ metabolism and are bioactivated by

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7

de, Barros Pereira I. M. "Investigation of biomarkers of hepatic and renal toxicity in the Han Wistar rat." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1435551/.

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The aim of this project was to identify urinary markers of hepatic and renal toxicity in the male Hanover-Wistar rat; acute and chronic injury models were developed by administration of CCl4. Nephrotoxicity was induced by administration of HCBD. In an acute dose study, CCl4-induced nephrotoxicity occurred above 2.0 mL/kg CCl4. To avoid kidney injury, 2.0 mL/kg CCl4 was chosen as the optimal dose. 1H NMR revealed many changes to the urinary metabolome following CCl4-induced liver injury including an increase in the resonances of taurine, creatine and formate and a decrease in hippurate and crea

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8

Secker, Philipp Fabian [Verfasser]. "Functional approaches to study renal and mitochondrial toxicity in vitro / Philipp Fabian Secker." Konstanz : KOPS Universität Konstanz, 2018. http://d-nb.info/1217597700/34.

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9

McLaren, John. "Human renal proximal tubular cells, in suspension and primary culture, as in vitro models of drug-induced nephrotoxicity." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU545620.

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The kidney is the target for a wide variety of chemical agents, including heavy metals, haloalkenes, analgesics and antibiotics. The functional and metabolic characteristics of the proximal tubule (PT) predispose it as the primary site for xenobiotic damage. The aim of this study was to isolate and characterise human and rat PT cells in suspension and primary culture for use as defined models to investigate drug-induced PT cell damage in vitro . A second aim was to compare the response of human and rat systems to known nephrotoxins. Human and rat PT cells (90&'37 viable) were isolated from kid

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10

Sousa, Fabiola Carine Monteiro de. "Efeito renal do veneno da Brothrops erythromelas e bloqueio induzido pelo fator antibotrÃpico do Didelphis marsupialis." Universidade Federal do CearÃ, 2004. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=269.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Some animals present natural resistance to the effects of snake venoms that can be explained by the presence of neutralizing factors in their blood serum. The resistance of South American Didelphis marsupialis, against crotalid venoms, especially of the genus Bothrops, of utmost medical importance in Brazil, has been object of investigation in the last few years. Bothrops erythromelas, known as âjararaca-da-secaâ or âjararaca-malha-de-cascavelâ is responsible for a great deal of snakebites in Northeastern Brazil. The venom of this

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11

Pereira, Leonardo Victor Barbosa. "Efeito protetor da N-Acetilcisteína sobre a nefrotoxicidade de meios de contraste baseados no gadolínio em modelo experimental de doença renal crônica." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-13062012-134114/.

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INTRODUÇÃO: O Gadolínio (Gd) é um raro metal da classe dos lantanídios usado como meio de contraste devido as suas propriedades paramagnéticas. Após sua descoberta, foi considerado um contraste pouco nefrotóxico em pacientes com doença renal crônica (DRC). Atualmente, existem evidências de que o Gd pode apresentar nefrotoxicidade semelhante aos contrastes iodados. A administração de Gadolínio em ratos com DRC pode levar a piora da função renal aferida por clearance de inulina e mobilização do ferro corporal gerando stress oxidativo. OBJETIVOS: O objetivo do estudo foi avaliar o efeito do Gd na

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12

Peixoto, Nilce Coelho. "PREVENÇÃO DOS EFEITOS TÓXICOS DO CLORETO DE MERCÚRIO EM RATOS JOVENS PELO CLORETO DE ZINCO: PAPEL DAS METALOTIONEÍNAS." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/4439.

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Zinc, cadmium, and mercury are divalent metals and constitute same group of the periodic table. While zinc is an essential metal, the others are toxic metals. The most important common feature among these metals is the ability to induce the synthesis of metallothioneins (MT), which occurs in two vital organs involved in detoxification, the liver and kidney. The main role of MT is the detoxification of heavy metals and the regulation of homeostasis of essential trace metals, such as copper and zinc. There are several studies about mercury toxicity and the role of MT in adult animals. However, t

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13

Ruiz, San Millán Juan Carlos. "Estudio de los efectos de los inhibidores de mTOR en el trasplante renal." Doctoral thesis, Universidad de Cantabria, 2010. http://hdl.handle.net/10803/10703.

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Los resultados del trasplante renal a largo plazo están limitados por la pérdida a largo plazo del injerto y la muerte con injerto funcionante. Los inmunosupresores tienen gran importancia por su efecto sobre el injerto (control de la respuesta inmunológica y nefrotoxicidad) y sobre los factores de riesgo cardiovascular y el desarrollo de neoplasias. Los nuevos inmunosupresores apuntan a un mejor perfil en este sentido para reducir estos dos tipos de complicaciones y prolongar la supervivencia del injerto y del paciente, siendo los fármacos del grupo mTOR los más prometedores en este sentido.

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Eira, Margareth da. "\"Alterações na função renal em pacientes HIV/AIDS tratados com esquemas terapêuticos incluindo indinavir\"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-10052005-150439/.

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Complicações renais e urológicas incluindo nefrolitíase, cristalúria, cólica renal e lombalgia, são eventos adversos bem conhecidos do indinavir (IDV), um inibidor de protease (IP) largamente utilizado no tratamento de pacientes infectados com o vírus da imunodeficiência humana (HIV). Prévios estudos em ratos demonstraram que o IDV, um potente IP capaz de provocar uma sustentada supressão da carga viral do HIV, induz vasoconstricção renal, diminui a filtração glomerular (RFG) e reduz a excreção urinária de nitrito (NO2-), sugerindo que a vasoconstricção causada pelo IDV deve ser mediada pelo ó

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15

Pinho, Fábia Maria Oliveira. "Insuficiência renal aguda após envenenamento crotálico: prevalência e fatores de risco - um estudo prospectivo." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-10042007-141228/.

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O envenenamento crotálico é responsável por, aproximadamente, 10% dos acidentes causados por serpentes peçonhentas no Brasil. A peçonha crotálica possui ação neurotóxica, miotóxica, nefrotóxica e coagulante. Insuficiência renal aguda (IRA) é a principal complicação nas vítimas que sobrevivem aos efeitos iniciais da peçonha, sendo importante causa de óbito para esses pacientes. Os objetivos deste estudo foram determinar prospectivamente a prevalência e os fatores de risco relacionados ao desenvolvimento de IRA após envenenamento crotálico. Foram estudadas 100 vítimas de acidente crotálico admit

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16

Abreu, Benedita Andrade Leal de. ""Avaliação da função renal com estudos radioisotópicos (DTPA-99mTc, DMSA-99mTc e EC-99mTc) em pacientes submetidos à quimioterapia com agentes nefrotóxicos"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5151/tde-24052006-144721/.

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Pacientes com diagnósticos oncológicos diversos sob terapia com agentes nefrotóxicos, foram avaliados através de procedimentos radioisotópicos, em três momentos diferentes. Os achados radioisotópicos foram comparados com as avaliações laboratoriais rotineiras. Não mostraram alterações estatisticamente significativas os seguintes parâmetros: uréia, creatinina, sedimentos anormais e índice de Crockoft-Gault. Concluiu-se que a avaliação da função renal com os métodos rotineiramente utilizados na prática oncológica não foram estatisticamente significativas. Dentre os estudos utilizando radionuclíd

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17

Marcelino, Renato Ivan de Ávila. "Estudo da atividade quimioprotetora in vitro e in vivo da Eugenia dysenterica dc. (Myrtaceae) após exposição ao cromo hexavalente." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3679.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-24T12:08:05Z No. of bitstreams: 2 Dissertação - Renato Ivan de Ávila Marcelino - 2013.pdf: 1307159 bytes, checksum: 353b525742af80ec75afbd4c58f79c96 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-24T14:01:41Z (GMT) No. of bitstreams: 2 Dissertação - Renato Ivan de Ávila Marcelino - 2013.pdf: 1307159 bytes, checksum: 353b525742af80ec75afbd4c58f79c96 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a77147

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18

Kane, Amadou. "Intoxication subchronique par l'ochratoxine a, mycotoxine contaminant les aliments : effets nephrotoxiques et genotoxiques." Strasbourg 1, 1986. http://www.theses.fr/1986STR13126.

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Distribution tissulaire de l'ochratoxine marquee chez le rat et la souris (voie orale). Etude de la nephrotoxicite subchronique de doses faibles chez le rat en suivant dans l'urine et les tubules la variation des activites enzymatiques. Effet sur les enzymes de cellules renales mdck en culture. Etude de la genotoxicite de l'ochratoxine in vivo et in vitro

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19

Vargas, MariÌa Angeles MartiÌnez. "Real-time monitoring of cellular toxicity using electrical impedance measurements." Thesis, University of the West of England, Bristol, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444490.

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20

BRILLET, GEORGES. "Toxicite renale chronique du cisplatine : etude clinique et experimentale." Reims, 1992. http://www.theses.fr/1992REIMM065.

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21

Dadoun, Moreau Christine. "Etude expérimentale de la néphrotoxicité d'un agent antitumoral, le méthyl-2 hydroxy-9 ellipticinium, chez le rat." Rouen, 1988. http://www.theses.fr/1988ROUES024.

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22

Puigmulé, Raurich Marta. "Caracterització dels sistemes renals de ratolí i humà (PCT3 i HK-2). Mecanismes moleculars implicats en la nefrotoxicitat produïda per la CsA en el túbul proximal renal." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/1021.

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La CsA és un potent immunosupressor àmpliament utilitzat en el trasplantament d'òrgans sòlids que com a principal efecte secundari mostra una elevada toxicitat renal que pot conduir a la pèrdua de la funció renal (Borel J.F. et al., 1976; Bennet W.M. et al., 1983). Els mecanismes moleculars pels quals la CsA exerceix els seu efecte immunosupressor han estat ben estudiats (Schreiber S.L., 1991; Liu J. et al., 1992), no obstant poc es coneix dels mecanismes d'acció a nivell molecular implicats en el dany renal. El tractament de cèl·lules PCT3 i HK-2 amb dosis creixents de CsA (desde 0 fins a 20

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Pujalte, Igor. "Étude in vitro de la toxicité de nanoparticules métalliques (TiO2, ZnO, CdS) sur la cible rénale." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21849/document.

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De nombreuses incertitudes persistent sur la toxicité potentielle des nanoparticules (NPs) et leur devenir dans l’organisme humain. L’objectif de ce travail est de mieux comprendre les mécanismes cytotoxiques induits par des NPs métalliques sur une cible secondaire, représentée par le rein. En effet, les NPs sont susceptibles de franchir les barrières cellulaires, d’être véhiculées par le sang pour se retrouver filtrées par le rein au niveau des cellules glomérulaires et peut-être, réabsorbées au niveau des cellules tubulaires. Cette étude est réalisée in vitro, avec des NPs métalliques de tit

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Joly, Véronique. "Etude experimentale des mecanismes mis en jeu dans la toxicite renale de l'amphotericine b libre et liposomale." Paris 7, 1991. http://www.theses.fr/1991PA077283.

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Notre travail avait pour objectif de preciser les mecanismes mis en jeu dans la toxicite renale de l'amphotericine b (amb), libre ou liposomale. Chez le lapin, une dose d'amb libre (4 mg/kg) reduit le dfg de 44% et altere les fonctions membranaires des cellules tubulaires proximales. L'amb liposomale, meme a forte dose (10 mg/kg), ne modifie aucun de ces parametres, mais augmente l'excretion urinaire de nag, suggerant une modification de la distribution et du site toxique de l'amb par les liposomes. In vitro, l'amb inhibe la captation active sodium-dependante de phosphate et d'hexose par les c

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Potdevin, Sophie. "Interaction des derives du platine avec les systemes de transport de la cellule tubulaire proximale renale." Paris 5, 1998. http://www.theses.fr/1998PA05N136.

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26

Rawson, Frankie James. "The design, development and application of a novel electrochemical biosensor/sensor system for the real-time monitoring of in-vitro cell toxicity." Thesis, University of the West of England, Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557140.

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In recent years there has been a reported requirement by the pharmaceutical and agrochemical industry that there is a need to monitor In vitro cell toxicity in real time, and also a necessity for using cell models that mimic the In vivo situation more closely. The aim of this project was to provide a solution for these key issues set out above. This was achieved by developing, characterising and implementing the use of electrochemical micro-biosensors and micro-sensors manufactured from screen printed electrodes. These were then used for monitoring cytotoxicity in HepG2 spheroids which mimic m

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Mavioso, Inês Cristina Violante da Cruz. "Identificação de espécies de Cianobactérias potencialmente tóxicas, no reservatório de Alqueva por PCR em Tempo Real e DNA barcoding." Master's thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/26522.

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As Cianobactérias são possivelmente os organismos procariotas fotossintéticos mais antigos existentes à face da Terra. O objetivo principal deste trabalho consistiu em estudar e caracterizar um bloom de Microalgas, a nível espacial, em três locais diferentes da albufeira de Alqueva, e ao longo da coluna de água, a diferentes profundidades. Foram realizadas análises físico-químicas, biológicas e moleculares. Os resultados dos parâmetros físico-químicos mostram que a albufeira se encontrava em período de estratificação. A plataforma de Lucefécit foi a que apresentou valores superiores de Clorofi

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Luz, Carla Patricia Novais. "Efeito agudo de metais pesados (Pb+2, Cd+2) sobre a regulação central da excreção renal de água, sódio e potássio." reponame:Repositório Institucional da FIOCRUZ, 1997. https://www.arca.fiocruz.br/handle/icict/5885.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-11-27T18:17:23Z No. of bitstreams: 1 Carla Patrícia Novais Luz Efeito agudo... 1997.pdf: 28638306 bytes, checksum: 690203708866521de7b4f58b702d4398 (MD5)<br>Made available in DSpace on 2012-11-27T18:17:23Z (GMT). No. of bitstreams: 1 Carla Patrícia Novais Luz Efeito agudo... 1997.pdf: 28638306 bytes, checksum: 690203708866521de7b4f58b702d4398 (MD5) Previous issue date: 1997<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>Trabalho realizado com o objetivo de estudar os possíve

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(UPC), Universidad Peruana de Ciencias Aplicadas, P. Thota, D. Pellegrino, et al. "A systematic review of the relative efficacy and toxicity of treatment regimens for HIV-associated cerebral toxoplasmosis: is trimephoprim-sulfamethaxozole a real option?" IDWeek, 2015. http://hdl.handle.net/10757/579779.

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Background: Pyrimethamine and sulfadiazine (P-S) combination is effective and considered the mainstay therapy for cerebral toxoplasmosis (CT). Alternative treatment regimens are available, but their relative efficacy and tolerability are not well known. Particularly, trimephoprim-sulfamethaxozole (TMP-SMX) shows potential advantages (i.e., tolerability, posology, parenteral formulation, cost, and accessibility) but its use is infrequent when P-S is available. Methods: We searched PubMed and 4 other databases to identify randomized controlled trials (RCTs) and cohort studies comparing differe

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Zu, Theresah Nom Korbieh. "Phenotypic and Metabolic Profiling of Biological Samples in Near Real-Time Using Raman Spectroscopy." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/65153.

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Raman spectroscopy, together with multivariate statistical analyses, has proven to be a near real-time analytical technique capable of phenotyping cells, tissues and organs. This dissertation will show exclusively the application of the Raman spectroscopy phenotypic profiling method to; (i) microbial toxicity, (ii) ex-vivo organ perfusion, and (iii) subcellular location targeting. Real-time analytical methods for monitoring living biological systems will enable study of the physiological changes associated with growth, genetic manipulations, and adverse environmental conditions. Most existi

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Glowacki, François. "Susceptibilité individuelle à la néphrotoxicité du Tacrolimus après transplantation rénale." Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S003/document.

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Le rein est particulièrement exposé à de nombreux composés chimiques dont des médicaments, potentiellement néphrotoxiques. Parmi-eux, le Tacrolimus, un anti-calcineurine largement utilisé en transplantation rénale, est associé à l’apparition plus ou moins rapide de lésions histologique de toxicité conduisant à la fibrose rénale et, à terme, à la perte de fonction du greffon. Des systèmes enzymatiques et protéiques impliqués dans la prise en charge cellulaire des xénobiotiques, ainsi que des protéines aux propriétés anti-fibrosantes, telles que la cavéoline-1, lui permettent de se défendre cont

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Arslan, Sevki. "Effects Of Benzene On Liver, Kidney And Lung Cyp1a, Cyp2b4, Cyp2e1 And Cyp3a6 Mrna, Protein Level, And Drug Metabolizing Enzyme Activities And Toxicity In Diabetic Rabbits." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609446/index.pdf.

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The effects of diabetes on cytochrome P450 dependent drug metabolizing enzymes have not to be clarified yet. The most widely used animals in these studies have been rats, and information regarding the effects of diabetes on cytochrome P450 dependent procarcinogen/carcinogen metabolism in rabbits is limited. In the present study, we investigated, for the first time, the influence of benzene on liver, kidney and lung microsomal cytochrome P450 dependent drug metabolizing enzyme activities, protein and mRNA levels in diabetic and non-diabetic rabbits. Male New Zealand rabbits were made diabetic

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Lagroye, Isabelle. "Intérêt des modèles glomérulaires in vitro en pharmacologie et toxicologie rénales." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P120.

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Nakashima, Brenda Lanza. "EXPRESSÃO DE GENES DE MEDIADORES CITOTÓXICOS POR CMSP TRATADAS COM PASTAS ENDODÔNTICAS INDICADAS PARA DENTES DECÍDUOS." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/6168.

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Iodoform (PI) and calcium hydroxide- based pastes (PH) are used in pulpectomy of primary teeth, complementing the antimicrobial action of mechanical chemical preparation and promoting tissue repair. These pastes take up and stay for a period of time along the root canal by contacting the periapical region and surrounding tissue, making it the aim of this study to quantify the relative expression of toxicity genes expressed by pastes, evaluating the biocompatibility these materials. By RT-PCR assay, were analyzed cellular mechanisms induced or generated by extracts of endodontic pastes: PI with

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Liu, Jing-Wen, and 劉靜雯. "Effect of Chinese herbal medicine on renal toxicity." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/06998104477989907569.

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碩士<br>國防醫學院<br>藥學研究所<br>101<br>中文摘要近年來，中藥所致腎臟損害日益受到人們的重視。多數藥物吸收後，主要經腎小球濾過、近曲小管分泌、遠曲小管重吸收和小管上皮細胞降解等代謝過程排出體外。在這一過程中均可累積腎毒性而發生結構和功能改變，導致腎臟損傷。中藥腎毒性已經成為制約中藥現代化和臨床應用的一大障礙。為了確保中藥的安全使用，有必要加強中藥的毒理學研究。然而，中藥製劑在台灣之使用相當普遍，因此中藥對腎臟之傷害機制尤其值得作深入之探討。研究發現馬兜鈴(Aristolochia)會造成腎臟損害，但中藥是否仍含其他成分會導致腎毒性，目前我國僅有少數相關文獻與研究。因此本篇研究目的為，挑選出使用較多之複方濃縮中藥，每種複方濃縮中藥選自三家藥廠之產品，主要以市售三大廠為主。中藥腎病變之可能機轉主要是與腎絲球過濾和腎小管分泌有關，因此當中藥傷害腎臟時最主要受到影響的地方便是腎絲球及腎小管。所以本篇研究採用近端腎小管細胞(LLC-PK1)與遠端腎小管細胞(MDCK) 來進行體外細胞模式及以SD大鼠為體內動物模式的篩選評估。體外細胞模式以模擬人體每日服用複方濃縮中藥之最大劑量且完全吸收，並進行劑量效應探討，以50%及10%濃度稀釋複方濃縮中藥之最大劑量，最後以10%處理濃度進行細胞存活率實驗，若細胞存活率低於75%，則判定此複方濃縮中藥可能具有腎毒性複方濃縮中藥經口

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Li-Hsiang, Wang, and 王麗香. "The Effect of Gancao on Guamutong-induced Acute Renal Toxicity in Rats." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/19239344876706427878.

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碩士<br>中國醫藥學院<br>中國醫學研究所<br>90<br>The Effect of Gancao on Guamutong-induced Acute Renal Toxicity in Rats Li-Hsiang Wang Institute of Chinese Medical Science, China Medical College Abstract The purpose of this experiment was to investigate how the effect of Gancao on Guamutong-induced acute renal toxicity in rats. Forty-eight female SD rats were randomly separated into eight groups – a control group; a group of 30 g/Kg of Guamutong in rat; a group of 30 g/Kg of Guamutong combined with 1 g/Kg of Gancao in rat; a group of 20 g/Kg of Guamutong in rat; a

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Peteherych, Kathy Dawn. "The effects of lipoproteins on cyclosporine A toxicity and uptake in renal cells." Thesis, 2000. http://hdl.handle.net/2429/10725.

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Cyclosporine A (CSA) is an effective immunosuppressant, but side effects such as renal toxicity can limit its therapeutic use. The hydrophobicity of CSA results in significant association of the drug with lipoproteins in the blood. Lipid levels in patients undergoing CSA therapy are correlated with CSA-induced renal toxicity. Renal damage in the glomerulus, the site of blood filtration, results in increased lipoprotein leakage into the proximal tubule, a major site of CSA toxicity. The current studies investigate the effects of lipoproteins on CSA-induced renal toxicity in the pig epithe

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Hsieh, Ying-Chieh, and 謝英杰. "The Epidemiology of Canine Feed-Induced Renal Failure and Feed Oral Toxicity Study in Rats." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/09876172616508533106.

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碩士<br>國立中興大學<br>獸醫學系暨研究所<br>95<br>In 2003-2004, an increasing incidence of canine renal failure draws great attention to the pet feed safety in Taiwan. The aim of this study was to investigate the potential causative factors of this incidence. Within the framework of the study, research aspects comprise in fact two lines of investigation that can be easily classified into epidemiology and toxicology. In an epidemic investigation from September, 2003 to May, 2004, 159 cases of renal failure were reviewed for their hematological and clinical biochemical characteristics. In addition, survey usi

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Chung, Nancy S. C. "The role of the low-density lipoprotein receptor family on Cyclosporine A uptake and toxicity in renal cells." Thesis, 2004. http://hdl.handle.net/2429/15474.

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Background: Cyclosporine A (CsA) is an effective immunosuppressant drug to treat patients who have undergone transplantation or to treat autoimmune diseases. However, the drug is limited by its narrow therapeutic index and usually becomes discontinued due to high nephrotoxicity. CsA is known to highly associate with lipoproteins, especially LDL and increased toxic effects of CsA have been reported in patients who are hypocholesterolemic. A significant reduction in [3H]CsA uptake and toxicity was observed when LLC-PK1 cells were treated with increased concentrations of LDL. Purpose: B

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Lin, Chiung-Cheng, and 林瓊錚. "Part 1：New Highly Selective Colorimetric and Fluorescent Chemosensors for Mercury IonPart 2：The Renal Toxicity of Tetrandrine." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/s8sbqb.

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碩士<br>靜宜大學<br>應用化學研究所<br>97<br>Part 1：New Highly Selective Colorimetric and Fluorescent chemosensors for Mercury Ion Three new chemodosimeters were prepared, they are 1-(4-(Trifluoro methyl) phenyl)-3-(pyren-1-yl) thiourea (1)、1-(4-nitrophenyl)-3-(pyren- 1-yl) thiourea (2)、1-(4-methoxyphenyl)-3-(pyren-1-yl) thiourea (3), respectively. Their chromogenic and fluorogenic chemodosimetric behaviors toward various metal cations were investigated. Receptors (1) to (3) show exclusively response toward Hg2+ ions and also distinguish Hg2+ from other metal cations by color changes. Among them, receptor (

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Pei-WenLiu and 劉蓓雯. "A study of preventive strategy and the mechanism of renal toxicity induced by food contaminants 3-MCPD and Glycidol." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/2pt95z.

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Wang, Yi-Chun, and 王奕鈞. "Investigation of the relationship betweendosage and the hepatoxicity/renal toxicityof Tripterygium wilfordii." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/11423120802984846463.

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碩士<br>中國醫藥大學<br>藥物安全研究所<br>98<br>Introduction: In order to conserve the medication security in Chinese medicine, the Committe on Chinese Medicine and Pharmacy, Department of Health, Executive Yuan had carried out several plans about the medication security in Chinese medicine for several years. Identify with Chinese medicine, using mistake, package, toxicity, increase or decrease the effect or toxicity when combined use of the Chinese medicine and medicine, trumpet the medicine security and compose the Chinese medicine pharmacopoeia were included in those plans. Tripterygium wilfordii, a plant

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Kao, Wei Chen, and 高煒展. "A Comparison of the Results of Several Freshwater Aquatic Toxicity Testing on Synthetic and Real Wastewaters." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/82684811244403003290.

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碩士<br>國立交通大學<br>環境工程所<br>89<br>The purpose of this research is to compare the results of several freshwater aquatic toxicity tests on synthetic and real wastewater. Based on the findings, this research has discovered that the sensitivity of standard algal toxicity test (Batch tests) on organic compound, especially on volatile organic compound is less receptive than other toxicity test method, such as fish or water fleas toxicity test. Furthermore, this research reveals that by using BOD bottles on algal toxicity test can enhance the sensitivity on testing volatile organic compound in terms of

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Lammer, Eva [Verfasser]. "Refinement of the fish embryo toxicity test (FET) with zebrafish (Danio rerio) : is it a real replacement of the acute fish toxicity test? [[Elektronische Ressource]] / presented by Eva Lammer." 2009. http://d-nb.info/995781737/34.

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Bernardo, Carla Alexandra Almeida. "Ozone for effluent treatments: kinetic studies and ecotoxicity evaluation." Master's thesis, 2021. http://hdl.handle.net/10316/98219.

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Dissertação de Mestrado Integrado em Engenharia Química apresentada à Faculdade de Ciências e Tecnologia<br>Currently, to face the exponential growth of the population as well as of the industries, the existence of large amounts of water is necessary. However, the scarcity of this resource is a problem that is faced daily across the world. The recovery of effluents emerges as an increasingly pertinent topic, which assists the solving of this problem, however the path to resolution is long. The increase in the consumption of pharmaceutical products by the general population, as well as the use

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