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Dissertations / Theses on the topic 'REV liposomes'

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Published: 2 June 2025
Last updated: 31 July 2025

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1

Voelker, Dirk. "Interactions of Ruthenium Red with Phospholipid Vesicles." PDXScholar, 1994. https://pdxscholar.library.pdx.edu/open_access_etds/4881.

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We have studied the electrostatic and other interactions of the inorganic, hexavalent dye Ruthenium Red (RR) with phospholipid vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS) or phosphatidylinositol (Pl) in various mixtures and concentrations. Experiments were based on spectrophotometric absorption measurements which compared RR concentrations in the presence and in the absence of liposomes at different dye concentrations. Multilamellar liposomes were obtained by handshaken preparations. Five freeze-and-thaw cycles of the lipid-RR suspension produced an ion equilibriu
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2

McNeeley, Kathleen Margaret. "Modulating liposomal stealth properties to evade RES and target tumors." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26650.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Ravi V. Bellamkonda; Committee Member: Ananth V. Annapragada; Committee Member: Andrew Lyon; Committee Member: Gang Bao; Committee Member: Niren Murthy. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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3

Daswani, Varsha. "Fluorescence and aggregation properties of the anti-cancer drug, CA4P, in archaeal liposomes." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/334013.

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Biomedical Sciences<br>Ph.D.<br>Combretastatin A4 phosphate (CA4P) is a potent vascular disrupting agent utilized in the treatment of cancer. The observed rapid vascular shutdown post administration as well as its potency at 1/10th of the established maximum tolerated dose (MTD) have made it one of the most prevalent tubulin binding agents. CA4P is currently involved in 19 clinical trials. Unfortunately, as is the case with most forms of chemotherapy, the off target effects associated with its use can be prohibitive for a large percentage of cancer patients. The advantages associated with the
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4

Santos, Marina. "ANALYTICAL POTENTIAL OF POLYMERIZED LIPOSOMES BOUND TO LANTHANIDE IONS FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF PROTEINS." Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2587.

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One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in t
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5

Santos, Marina. "ANALYTICAL POTENTIAL OF POLYMERIZED LIPOSOMES BOUND TO LANTHANIDE IONS FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF PROTEINS." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2588.

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One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in t
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6

Ayesa, Umme. "CHARACTERIZATION OF THERMOSENSITIVE HYBRID ARCHAEOSOMES AND DPA-CY3[22,22]/POPC LIPOSOMES AND IN VITRO EVALUATION OF THEIR POTENTIAL USEFULNESS IN TARGETED DELIVERY AND CONTROLLED RELEASE." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/368614.

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Biochemistry<br>Ph.D.<br>One of earlier challenges in treating cancer was utilizing drugs that are powerful yet do not cause severe toxicity to patients. Although the use of liposomal drugs has somewhat met that challenge, our objective now is to create liposomal drugs with an even better drug efficacy and further reduced toxicity. Doxorubicin hydrochloride (DXO), for example, is an anticancer drug used to treat many types of cancers, but it is toxic to the gastrointestinal tract and the heart. Encapsulating DXO into liposomes as done in the first FDA-approved liposomal DXO, Doxil, minimizes t
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7

Rosano, Jenna Marie. "Engineering Nanoparticles for Targeted Delivery of Growth Factors to Prevent Cardiac Remodeling After an MI." Master's thesis, Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/82332.

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Mechanical Engineering<br>M.S.E.<br>Myocardial infarction (MI) is a leading cause of death in the United States, claiming the lives of approximately 500,000 people each year. The infarcted heart undergoes a compensatory process called cardiac remodeling, which adversely changes left ventricular (LV) size and function and eventually may lead to heart failure. To date, the only clinical treatments for this condition include surgical restoration of blood flow to the ischemic region (e.g., angioplasty), or pharmacological treatments (e.g., angiotensin converting enzyme inhibitors) which indirectly
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8

Chaineau, Mathilde. "Régulation du trafic vésiculaire : rôle de la protéine Hrb dans l'endocytose de la SNARE vésiculaire TI-VAMP/VAMP7." Paris 6, 2009. http://www.theses.fr/2009PA066022.

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Le trafic membranaire assure la communication entre les différents compartiments intracellulaires ainsi qu’entre les cellules et leur environnement via l’exocytose et l’endocytose. Les protéines SNARE vésiculaires (v-SNARE) et leurs partenaires à la membrane cible (t-SNARE) sont responsables de la fusion membranaire. Des travaux antérieurs ont montré le rôle de la v-SNARE TI-VAMP dans une voie d’exocytose impliquée dans la croissance neuritique et le remodelage de la membrane plasmique. Le domaine amino-terminal Longin de TI-VAMP régule l'activité fusogénique de la protéine et son ciblage. J'a
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9

Rescia, Vanessa Cristina [UNIFESP]. "REVs-Chi: um novo sistema particulado para encapsulação de macromoléculas terapêuticas." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/10065.

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Made available in DSpace on 2015-07-22T20:50:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-07-29<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A quitosana (Chi), a (1-4)-amino-2-desoxi-ƒÒ-glicana, e a forma desacetilada da quitina, um polissacarideo das conchas de crustaceos. As suas caracteristicas unicas como a carga positiva, biodegradabilidade, biocompatibilidade, atoxicidade e estrutura rigida fazem com que esta
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10

Gottschalk, Ingo. "Chromatographic Studies of Solute Interactions with Immobilized Red Blood Cells and Biomembranes." Doctoral thesis, Uppsala University, Department of Biochemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2668.

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<p>Specific and non-specific interactions of solutes with immobilized biomembranes were studied using chromatographic methods. Liposomes, proteoliposomes and red blood cell (RBC) membrane vesicles were immobilized by a freeze-thawing procedure, whereas whole RBCs were adsorbed in the gel beds using electrostatic interaction, binding to wheat germ agglutinin (WGA) or the streptavidin-biotin interaction. </p><p>Superporous agarose gel with coupled WGA was the most promising matrix for RBC adsorption and allowed frontal chromatographic analyses of the cells for about one week. Dissociation consta
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11

Zhu, Weiwei. "Effects of Membrane Lateral Organization on the Anticancer Activity of Liposomal CA4P against MCF-7 Breast Cancer Cells." Master's thesis, Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/87353.

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Biochemistry<br>M.S.<br>The goal of this research is to study how the cholesterol content in liposomal formulations affects the anticancer activity (e.g., cell growth suppression) of combretastatin A4 phosphate (CA4P). CA4P is a powerful antivascular agent currently under clinical trials for treating solid tumors. Liposomal CA4P has several advantages over free CA4P, including the reduced toxicities and the increased overall drug efficacy. In this thesis work, I have demonstrated that the proliferation of breast cancer MCF-7 cells varies with the cholesterol mole fraction in the formulation of
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12

Rameez, Shahid. "Engineering Cellular Hemoglobin-Based Oxygen Carriers For Use In Transfusion Medicine." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1322552700.

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13

Lagerquist, Hägglund Christine. "Affinity-, Partition- and Permeability Properties of the Human Red Blood Cell Membrane and Biomembrane Models, with Emphasis on the GLUT1 Glucose Transporter." Doctoral thesis, Uppsala University, Department of Biochemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3525.

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<p>The human glucose transporter GLUT1 is abundant in red blood cells, the blood-brain barrier and epithelial cells, where it mediates the transport of the energy metabolite, glucose. In the present work some properties of GLUT1, including affinity binding of both substrates and inhibitors, transport rates as well as permeabilities of aromatic amino acids and drug-membrane interactions were analyzed by chromatographic methods.</p><p>Reconstitution by size-exclusion chromatography on Superdex 75 from a detergent with a low CMC that provides monomeric GLUT1 was examined regarding D-glucose- and
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14

Gazeli, Kristaq. "Étude expérimentale de micro-plasmas froids à la pression atmosphérique générés par des hautes tensions de formes différentes." Thesis, Pau, 2015. http://www.theses.fr/2015PAUU3019/document.

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Cette thèse porte sur l'étude de micro-plasmas froids à la pression atmosphérique générés à partir de différents réacteurs des configurations basées sur le principe des Décharges à Barrière Diélectrique (DBD) et alimentés par des générateurs de tension impulsionnelle et sinusoïdale. Les plasmas sont formés dans des gaz nobles tels que l'hélium et l'argon (gaz vecteurs), et également dans des mélanges réalisés avec des gaz moléculaires tels que l'azote et l'oxygène afin de produire des Espèces Réactives de l’Azote et de l’Oxygène (ERA, ERO). La (ré)activité chimique du pla
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15

Chen, Won Ko, and 陳宛珂. "The Study Liposome Encapsulated Hemoglobin as Artificial Red Blood Cell." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/01856622100985296841.

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16

Larson, Gretchen Marie. "Development of anionic liposomal carriers containing listeriolysin O and red blood cell ghosts as plasmid DNA delivery platforms." 2004. http://books.google.com/books?id=rjVtAAAAMAAJ.

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17

CHENG, YI-YI, and 鄭逸意. "Study of Drug ( Gadolinium ) Release Efficiency of Boronic Acid Modified Liposome Binding with Red Blood Cell Antibody by Nuclear Magnetic Resonance Dispersion ( NMRD )." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/g6v3f2.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>105<br>The target of this research is to synthesis a Boronic acid modified liposome, binding with red blood cell antibody. Studying of drug ( Gadolinium, Gd ) efficiency from this liposome by Nuclear Magnetic Resonance Dispersion ( NMRD ), and further investigating the molecular dynamic in this system. 　　As the application of Magnetic Resonance Imagine ( MRI ) in medical diagnosis is becoming more and more widely, the research of contrast agent is becoming more and more important. However, Gadolinium, the major component of contrast agent is harmful to human body.
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18

Fraenza, Carla Cecilia. "Caracterización de la dinámica molecular en nanoestructuras supramoleculares globulares mediante relaxometría magnética nuclear." Doctoral thesis, 2016. http://hdl.handle.net/11086/4042.

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Tesis (Doctor en Física)--Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación, 2016.<br>Utilizando diferentes técnicas de resonancia magnética nuclear, principalmente la relaxometría con ciclado rápido de campo magnético, se llevaron a cabo estudios de dinámica molecular, los que permitieron analizar propiedades mesoscópicas en diferentes estructuras supramoleculares globulares. Se midió la tasa de relajación espín-red de protones con esta técnica, en liposomas unilamelares. Se extendió exitosamente a sistemas más complejos (liposomas dopados con colestero
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