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Journal articles on the topic 'REV liposomes'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Khusbu, ,., Avinash Kumar Gupta, Manish Kumar Gupta, and Vijay Sharma. "Development of liposome encapsulated curcumin for treatment of arthritis." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 374–81. http://dx.doi.org/10.22270/jddt.v9i4.3062.

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Liposomesof curcumin was prepared by Thin Film Hydration method (TFH) and Reverse Phase Evaporation Method (REV) methods and Freeze-thaw (F-T) cycles were carried out for liposomes prepared by both the methods, then optimized with regard to percentage drug entrapment by changing various process and formulation parameters, various compositions of optimized liposomal batches along with their PDE and mean vesicle size values are recorded. Prepared liposomes prior to size reduction were suitable for nasal delivery as then vesicle size distribution was in range of 10-20 pm that is required for nasa

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Vitali, Alberto, Patrizia Paolicelli, Barbara Bigi, et al. "Liposome Encapsulation of the Palmitoyl–KTTKS Peptide: Structural and Functional Characterization." Pharmaceutics 16, no. 2 (2024): 219. http://dx.doi.org/10.3390/pharmaceutics16020219.

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In this study, the amphiphilic N-palmitoyl–KTTKS peptide was integrated in the bilayer of egg-derived phosphatidylcholine (PC) vesicles using two different preparation methods, namely thin-film evaporation (TLE) and reverse-phase evaporation (REV). Both the REV and TLE methods allowed for the formation of homogeneous liposome dispersions (PdI < 0.20) with mean hydrodynamic diameters of <100 nm and <200 nm, respectively, a net negative surface charge and a percentage of structured phospholipids higher than 90%. The inclusion of the amphiphilic N-palmitoyl–KTTKS peptide within phospholi

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Sharma, Neeraj, Abhilasha Singh, Pragati Baghel, Vikas Chandra Sharma, Gajendra Singh Rathore, and Shivani Vishwakarma. "Formulation Characterization and Optimization of Photosensitive Liposomes for Targeted Drug Delivery Using UV Light Activation." Journal of Neonatal Surgery 14, no. 6S (2025): 481–87. https://doi.org/10.52783/jns.v14.2255.

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This study explores the formulation, characterization, and optimization of photosensitive liposomes for targeted drug delivery activated by UV light. Liposomes, self-forming spherical vesicles made of phospholipids, are effective carriers for drugs, offering the advantage of localized delivery and reduced systemic distribution. The research focuses on incorporating non-steroidal anti-inflammatory drugs (NSAIDs), specifically Ketoprofen (KP), into liposomes using the reverse phase evaporation (REV) method, achieving high encapsulation efficiency. Optimization studies revealed that increasing ch

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Nasedkin, Alexandr, Jan Davidsson, and Mont Kumpugdee-Vollrath. "Determination of nanostructure of liposomes containing two model drugs by X-ray scattering from a synchrotron source." Journal of Synchrotron Radiation 20, no. 5 (2013): 721–28. http://dx.doi.org/10.1107/s0909049513020074.

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Small-angle X-ray scattering has been employed to study how the introduction of paracetamol and acetylsalicylic acid into a liposome bilayer system affects the system's nanostructure. An X-ray scattering model, developed for multilamellar liposome systems [Pabstet al.(2000),Phys. Rev. E,62, 4000–4009], has been used to fit the experimental data and to extract information on how structural parameters, such as the number and thickness of the bilayers of the liposomes, thickness of the water layer in between the bilayers, size and volume of the head and tail groups, are affected by the drugs and

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Cheraga, Nihad, Ammar Ouahab, Yan Shen, and Ning-Ping Huang. "Characterization and Pharmacokinetic Evaluation of Oxaliplatin Long-Circulating Liposomes." BioMed Research International 2021 (April 20, 2021): 1–14. http://dx.doi.org/10.1155/2021/5949804.

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The clinical efficacy of Oxaliplatin (L-OHP) is potentially limited by dose-dependent neurotoxicity and high partitioning to erythrocytes in vivo. Long-circulating liposomes could improve the pharmacokinetic profile of L-OHP and thus enhance its therapeutic efficacy and reduce its toxicity. The purpose of this study was to prepare L-OHP long-circulating liposomes (L-OHP PEG lip) by reverse-phase evaporation method (REV) and investigate their pharmacokinetic behavior based on total platinum in rat plasma using atomic absorption spectrometry (AAS). A simple and a sensitive AAS method was develop

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Lim, Sun Kyung, Heon Joo Park, Eun Kyung Choi, and Jin Seok Kim. "Long-Circulating, Temperature-Sensitive and EGFR-Targeted Liposomes for Drugs Delivery." Key Engineering Materials 342-343 (July 2007): 537–40. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.537.

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Effectiveness of epidermal growth factor receptor(EGFR)-targeted, long circulating and temperature-sensitive liposomes(TSLs) is described using sterically stabilized gemcitabine-loaded liposomes in vitro. Development of long-circulating formulation of TSLs with the EGFR antibody attached was designed to expect an increase in binding and drug delivery efficiency to the target cells such as non-small cell lung cancer cells(A549) and human pancreatic carcinoma cells(PANC- 1). New TSLs were prepared using DPPC:DMPC:DSPC(4:1:1 molar ratio) by the REV method. Differential scanning calorimetry of TSL

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Garello, Francesca, Rachele Stefania, Silvio Aime, Enzo Terreno, and Castelli Daniela Delli. "Successful Entrapping of Liposomes in Glucan Particles: An Innovative Micron-Sized Carrier to Deliver Water-Soluble Molecules." Mol Pharm. 11, no. 10 (2014): 3760–5. https://doi.org/10.1021/mp500374f.

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Glucan particles (GPs) are monodisperse microspheres derived from baker's yeast and represent an interesting class of microcarriers for theranostic applications as they show a high affinity toward immune system cells. The typical loading strategy was to harness the ability of the molecule to be loaded to interact with nano-/microassembled systems through electrostatic or hydrophobic forces. However, small water-soluble chemicals could not be steadily retained by the leaky shell of GPs. In this work, we propose an alternative loading approach for small water-soluble compounds that is based

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Okada, E., S. Sasaki, N. Ishii, et al. "Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens." Journal of Immunology 159, no. 7 (1997): 3638–47. http://dx.doi.org/10.4049/jimmunol.159.7.3638.

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Abstract A DNA vaccine constructed with the CMV promoter conjugated to env gp160 and rev genes has been shown to induce an effective Th1-type immune response when inoculated via an intramuscular route. In the present study, we obtained high levels of both humoral and cell-mediated immune activity by intranasal administration of this DNA vaccine. The production of mucosal IgA Ab in feces and vaginal fluid was stimulated significantly by intranasal DNA administration. This route of administration resulted in a significant level of HIV-1-neutralizing Abs in feces and serum. Cytokine assays reveal

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Cyboran-Mikołajczyk, Sylwia, Przemysław Sareło, Robert Pasławski, et al. "Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties." International Journal of Molecular Sciences 22, no. 4 (2021): 1710. http://dx.doi.org/10.3390/ijms22041710.

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Liposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome–erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidylcholine-composed liposomal formulations of Photolon, used as a drug model, significantly influences the transmembrane potential, stiffness, as well as the shape of RBCs. These changes caused decreasing the number of stomatocytes and irregular shapes

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Chronopoulou, Laura, Francesca Falasca, Federica Di Fonzo, Ombretta Turriziani, and Cleofe Palocci. "siRNA Transfection Mediated by Chitosan Microparticles for the Treatment of HIV-1 Infection of Human Cell Lines." Materials 15, no. 15 (2022): 5340. http://dx.doi.org/10.3390/ma15155340.

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Gene delivery is the basis for developing gene therapies that, in the future, may be able to cure virtually any disease, including viral infections. The use of short interfering RNAs (siRNAs) targeting viral replication is a novel strategy for treating HIV-1 infection. In this study, we prepared chitosan particles containing siRNA tat/rev via ionotropic gelation. Chitosan-based particles were efficiently internalized by cells, as evidenced by fluorescence microscopy. The antiviral effect of chitosan-based particles was studied on the C8166 cell line infected with HIV-1 and compared with the us

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Lin, Xian, Bozhe Li, Jing Wen, et al. "Storage Stability and In Vitro Bioaccessibility of Liposomal Betacyanins from Red Pitaya (Hylocereus polyrhizus)." Molecules 27, no. 4 (2022): 1193. http://dx.doi.org/10.3390/molecules27041193.

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In order to address the poor stability of the betacyanins from red pitaya (Hylocereus polyrhizus, HP), which are considered as good sources of natural colorant, liposomal-encapsulation technique was applied in this study. Thin-layer dispersion method was employed to prepare HP betacyacnin liposomes (HPBL). The formulation parameters for HPBL were optimized, and the characteristics, stability, and release profile of HPBL in in vitro gastrointestinal systems were evaluated.Results showed that an HP betacyanin encapsulation efficiency of 93.43 ± 0.11% was obtained after formulation optimization.

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Elin, Gitlesen, McGinn Susanne, Mohamed Nadia, Saadani Ali, and H. Hagagy Rahma. "Modified Polymeric Surface Liposomal Vitamin C as an Advanced and Effective Formulation in Topical Skin Applications." Sarcouncil Journal of Biomedical Sciences 3, no. 12 (2024): 1–12. https://doi.org/10.5281/zenodo.14533820.

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This study evaluates and compares the anti-oxidation protective effects of two liposomal vitamin C formulations LipoVITA<sup>®</sup> C (conventional liposomal vitamin C formulation) and LipoVITA<sup>®</sup> C PLUS (an advanced modified polymeric surface liposome) against non-liposomal vitamin C (NL- VC). The study employs cell viability assay using human skin fibroblasts exposed to UV radiation module. Vitamin C is a potent but unstable antioxidant; liposomal encapsulation stabilizes it and enhances its efficacy. Human skin fibroblasts were treated with varying concentrations of LipoVI

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Rajendran, Vinoth, Shilpa Rohra, Mohsin Raza, Gulam Mustafa Hasan, Suparna Dutt, and Prahlad C. Ghosh. "Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria." Antimicrobial Agents and Chemotherapy 60, no. 3 (2015): 1304–18. http://dx.doi.org/10.1128/aac.01796-15.

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The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs. Therefore, there is a critical need to develop an efficient drug delivery system to circumvent drug resistance. The anticoccidial drug monensin, a carboxylic ionophore, has been shown to have antimalarial properties. Here, we developed a liposome-based drug delivery of monensin and evaluated its antimalarial activity in lipid formulations of soya phosphatidylcholine (SPC) cholesterol (Chol) containing either stearylamine (SA) or phosphatidic acid (PA) and different densities

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Bonatto, Cínthia Caetano, Graziella Anselmo Joanitti, and Luciano Paulino Silva. "Red Blood Cell-Based Delivery Systems for the Release of Hemoglobin-Derived Peptides with In Vitro Antitumor Activities." Pharmaceuticals 18, no. 4 (2025): 570. https://doi.org/10.3390/ph18040570.

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Background/Objectives: This study aimed to develop liposomes derived from lipids obtained from red blood cell membranes for potential use in antitumor applications. Hemoglobin hydrolysates exhibiting peptides with known antitumor activities were encapsulated within these liposomes. Methods: The developed liposomal systems were characterized by their physicochemical properties, including size, surface charge, and encapsulation efficiency, and tested in vitro against 4T1 breast cancer cells and NIH3T3 fibroblasts. Results: Results indicated that the liposomes achieved effective encapsulation (88

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Liao, Yukun, Huiting Jiang, Yangrui Du, Xiaojing Xiong, Yu Zhang, and Zhiyu Du. "Using Convolutional Neural Network as a Statistical Algorithm to Explore the Therapeutic Effect of Insulin Liposomes on Corneal Inflammation." Computational Intelligence and Neuroscience 2022 (July 31, 2022): 1–9. http://dx.doi.org/10.1155/2022/1169438.

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Aiming at the disadvantages of easy recurrence of keratitis, difficult eradication by surgery, and easy bacterial resistance, insulin-loaded liposomes were prepared, and convolutional neural network was used as a statistical algorithm to build SD rat corneal inflammation model and study insulin-loaded liposomes, alleviating effect on corneal inflammatory structure in SD rats. The INS/PFOB@LIP was developed by means of thin-film dispersive phacoemulsification, its structure was monitored using a transmission electron microscope, particle size and appearance potential were monitored using a Malv

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Nguyen, Trang Thi Thuy, Seungjoo Haam, Joon-Seo Park, and Sang-Wha Lee. "Cysteine-Encapsulated Liposome for Investigating Biomolecular Interactions at Lipid Membranes." International Journal of Molecular Sciences 23, no. 18 (2022): 10566. http://dx.doi.org/10.3390/ijms231810566.

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The development of a strategy to investigate interfacial phenomena at lipid membranes is practically useful because most essential biomolecular interactions occur at cell membranes. In this study, a colorimetric method based on cysteine-encapsulated liposomes was examined using gold nanoparticles as a probe to provide a platform to report an enzymatic activity at lipid membranes. The cysteine-encapsulated liposomes were prepared with varying ratios of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and cholesterol through the hydration of lipid films and extrusions in the presence of cystei

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Hung, Chi-Feng, Jan-Kan Chen, Mei-Hui Liao, Huey-Ming Lo, and Jia-You Fang. "Development and Evaluation of Emulsion-Liposome Blends for Resveratrol Delivery." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 2950–58. http://dx.doi.org/10.1166/jnn.2006.420.

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Nano- and submicron-sized vesicles are beneficial for the controlled delivery of drugs. Resveratrol, the main active polyphenol in red wine, was incorporated into various combinations of emulsions and liposomes to examine its physicochemical characteristics and cardiovascular protection. The blends of emulsion-liposome were composed of coconut oil, soybean lecithin, glycerol formal, and non-ionic surfactants. Multiple systems were assessed by evaluating the droplet size, surface charge, drug encapsulation, release rate, and stability. The vesicle diameter of the systems ranged from 114 to 195

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Chang, Hsin-I., Chu-Wen Shao, Evelyn Huang, and Kuo-Yuan Huang. "Development of Astaxanthin-Loaded Nanosized Liposomal Formulation to Improve Bone Health." Pharmaceuticals 15, no. 4 (2022): 490. http://dx.doi.org/10.3390/ph15040490.

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Astaxanthin is a xanthophyll carotenoid commonly found in marine organisms. Due to its super antioxidative ability, astaxanthin has been widely applied as a human nutraceutical supplement for health benefits. In order to enhance the bioavailability of astaxanthin, we used soybean phosphatidylcholine to encapsulate astaxanthin for liposomal formation. The physical properties of astaxanthin (asta)-loaded liposomes were determined by particle size, encapsulation efficiency and polydispersity index. The results revealed that the particle sizes of asta-loaded liposomes with various concentrations e

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Ciavarra, R. P., K. Buhrer, N. Van Rooijen, and B. Tedeschi. "T cell priming against vesicular stomatitis virus analyzed in situ: red pulp macrophages, but neither marginal metallophilic nor marginal zone macrophages, are required for priming CD4+ and CD8+ T cells." Journal of Immunology 158, no. 4 (1997): 1749–55. http://dx.doi.org/10.4049/jimmunol.158.4.1749.

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Abstract Since extensive degradation may be required to present complex Ags, we addressed whether macrophages (M phi) might function as APC for anti-viral cell-mediated immune responses. To study this question, murine splenic M phi were depleted by i.p. administration of liposome-encapsulated dichloromethylene diphosphonate (Cl2MDP-liposomes or clodronate-liposomes) before priming mice with vesicular stomatitis virus (VSV). Cl2MDP-liposome treatment resulted in the rapid (1-day) depletion of splenic M phi that was associated with a suppression of the ability of M phi-deficient mice to generate

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Kihn, Lee, Dorothy Rutkowski, and Robert A. Stinson. "Incorporation of human liver and placental alkaline phosphatases into liposomes and membranes is via phosphatidylinositol." Biochemistry and Cell Biology 68, no. 9 (1990): 1112–18. http://dx.doi.org/10.1139/o90-166.

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As assessed by incorporation into liposomes and by adsorption to octyl-Sepharose, the integrity of the membrane anchor for the purified tetrameric forms of alkaline phosphatase from human liver and placenta was intact. Any treatment that resulted in a dimeric enzyme precluded incorporation and adsorption. An intact anchor also allowed incorporation into red cell ghosts. The addition of hydrophobic proteins inhibited incorporation into liposomes to varying degrees. Alkaline phosphatase was 100% releasable from liposomes and red cell ghosts by a phospholipase C specific for phosphatidylinositol.

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Shi, Xian He, Meng Chen, Yan Wen Wu, and Jie Ouyang. "Optimization of Ultrasonic-Assisted Preparation of Liposome-Encapsulated Paprika Red and its Improved Light Irradiation Stability." Advanced Materials Research 781-784 (September 2013): 1791–800. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.1791.

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Investigations were carried out to optimize ultrasonic-assisted preparation of liposome-encapsulated paprika red. The effect of process variables namely the ratio of soybean lecithin to paprika red, solvent volume, cholesterol content and sonication time was evaluated using single-factor test and response surface method (RSM). The liposomes showed significant effect on the improvement of light irradiation stability of paprika red, and the stability was greatly improved when antioxidants such as tert-butyl hydroquinone (TBHQ) or dl-α-tocopherol were introduced. The optimal ingredient for liposo

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Pascual-Silva, Carolina, Ailén Alemán, María Elvira López-Caballero, María Pilar Montero, and María del Carmen Gómez-Guillén. "Physical and Oxidative Water-in-Oil Emulsion Stability by the Addition of Liposomes from Shrimp Waste Oil with Antioxidant and Anti-Inflammatory Properties." Antioxidants 11, no. 11 (2022): 2236. http://dx.doi.org/10.3390/antiox11112236.

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Liposomes made of partially purified phospholipids (PL) from Argentine red shrimp waste oil were loaded with two antioxidant lipid co-extracts (hexane-soluble, Hx and acetone-soluble, Ac) to provide a higher content of omega-3 fatty acids. The physical properties of the liposomes were characterized by Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The antioxidant and anti-inflammatory activity of the lipid extracts and liposomal suspensions were evaluated in terms of Superoxide and ABTS radical scavenging capacities and TNF-α

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Tsai, Milton Hongli, Rohaya Megat Abdul Wahab, Shahrul Hisham Zainal Ariffin, Fazren Azmi, and Farinawati Yazid. "Enhanced Osteogenesis Potential of MG-63 Cells through Sustained Delivery of VEGF via Liposomal Hydrogel." Gels 9, no. 7 (2023): 562. http://dx.doi.org/10.3390/gels9070562.

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The challenges of using VEGF to promote osteoblastic differentiation include a short half-life and a narrow therapeutic window. A carrier system combining hydrogel and liposomes may improve the therapeutic efficacy of VEGF for bone regeneration. This study aimed to investigate the effects of delivery of VEGF via liposomal hydrogel on the osteogenesis of MG-63 cells. Liposomal hydrogel scaffold was fabricated and then characterized in terms of the morphological and chemical properties using FESEM and FTIR. In 2.5D analysis, the MG-63 cells were cultured on liposomal hydrogel + VEGF as the test

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Zian, Wang, Liu Yang, Wang Peng, Jiang Yifei, and Ji Min. "Small molecular interaction-based fluorescence enhancement for second near-infrared imaging." Nanomedicine 15, no. 2 (2020): 115–29. http://dx.doi.org/10.2217/nnm-2019-0233.

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Aim: This study described a new strategy to enhance second near-infrared (NIR-II) fluorescence intensity. Materials & methods: NIR-II liposomes were prepared by thin film hydration method and their fluorescence properties were evaluated. The efficacy of the optimized liposome was then evaluated in vivo with low dose and irradiation. Results: Indocyanine green-IR1061 liposome exhibited higher fluorescence intensity (∼fourfold than IR1061 liposome) with the red-shifted emission. The intensity of indocyanine green-IR1061 cationic liposome was enhanced to approximately tenfold, which allowed u

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de la Maza, A., J. L. Parra, P. Bosch, and L. Coderch. "Large Unilamellar Vesicle Liposomes for Wool Dyeing: Stability of Dye-Liposome Systems and Their Application on Untreated Wool." Textile Research Journal 62, no. 7 (1992): 406–13. http://dx.doi.org/10.1177/004051759206200708.

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Studies are described involving the use of large unilamellar liposomes (LUV) as carriers of dyes to untreated wool. To this end, we investigated liposomes made with egg phosphatidylcholine and containing the commercial acid dyes Polar red B (Ciba-Geigy), CI acid red 249, or Polar blue 6B, CI acid blue 83. We first studied the physicochemical stability of liposomes by measuring the mean particle size distribution of phospholipid vesicles after preparation and during the dyeing process, and we also investigated the possible hydrolysis of phospholipid molecules, studying the alteration of fatty a

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-. "Ferrodeficiency and pregnancy: what to do and when to begin?" REPRODUCTIVE ENDOCRINOLOGY, no. 62 (December 29, 2021): 42–46. https://doi.org/10.18370/2309-4117.2021.62.42-46.

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In September 2021, an online webinar took place on the most common nutritional deficiency in the world – iron deficiency. According to the WHO recommendations, women should definitely receive iron and folic acid, starting with the stage of pregravid preparation, during pregnancy and lactation. Other trace elements and vitamins during pregnancy must be substantiated by evidence of their deficiency. WHO recommendations (2017) for antenatal care indicate that daily oral iron supplementation 30–60 mg and folic acid 400 µg in pregnant women can reduce the incidence of postpartum s

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Lee, Hyunjin, Jihwan Son, Sae Kyung Min, et al. "A Study of the Effects of Doxorubicin-Containing Liposomes on Osteogenesis of 3D Stem Cell Spheroids Derived from Gingiva." Materials 12, no. 17 (2019): 2693. http://dx.doi.org/10.3390/ma12172693.

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The objective of the present investigation is to determine the effects of neutral, anionic, and cationic liposomes loaded with doxorubicin with thin-lipid-film-hydration method on the cellular viability and osteogenesis of stem cell spheroids. Spheroid formation and morphology of the three-dimensional spheroid were noted with an inverted microscope. Quantitative cellular viability was assessed using a commercially available kit. Osteogenic potential was evaluated by applying alkaline phosphatase activity and anthraquinone dye of Alizarin Red S. Western blot analysis was performed using collage

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Toan, Tran Quoc, Viet Anh Dang, Quoc Long Pham та ін. "Effects of Dietary Inclusion of Canthaxanthin- and α-Tocopherol-Loaded Liposomes on Growth and Muscle Pigmentation of Rainbow Trout (Oncorhynchus mykiss)". Journal of Food Quality 2021 (26 лютого 2021): 1–11. http://dx.doi.org/10.1155/2021/6653086.

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Dietary inclusion of canthaxanthin, a common carotenoid pigment, has been long practiced in aquaculture to give the favorable flesh color in farmed salmonids. However, carotenoids are associated with limited solubility and poor physicochemical stability, and their dose in fish feed is widely regulated. In this study, we included canthaxanthin- and α-tocopherol-loaded liposomes into fish diets and evaluated the effects of supplemented fish feed on fish growth, color, nutrition, and canthaxanthin deposition in fillets of cultured rainbow trout (Oncorhynchus mykiss). The liposomes were fabricated

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Liu, Yong-Ping, Chuan Li, Kuo-Kang Liu, and Alvin C. K. Lai. "The Deformation of an Erythrocyte Under the Radiation Pressure by Optical Stretch." Journal of Biomechanical Engineering 128, no. 6 (2006): 830–36. http://dx.doi.org/10.1115/1.2354204.

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In this paper, the mechanical properties of erythrocytes were studied numerically based upon the mechanical model originally developed by Pamplona and Calladine (ASME J. Biomech. Eng., 115, p. 149, 1993) for liposomes. The case under study is the erythrocyte stretched by a pair of laser beams in opposite directions within buffer solutions. The study aims to elucidate the effect of radiation pressure from the optical laser because up to now little is known about its influence on the cell deformation. Following an earlier study by Guck et al. (Phys. Rev. Lett., 84, p. 5451, 2000; Biophys. J., 81

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Ayllon, Marcelo, Gamid Abatchev, Andrew Bogard, Rosey Whiting, Sarah E. Hobdey, and Daniel Fologea. "Liposomes Prevent In Vitro Hemolysis Induced by Streptolysin O and Lysenin." Membranes 11, no. 5 (2021): 364. http://dx.doi.org/10.3390/membranes11050364.

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The need for alternatives to antibiotics in the fight against infectious diseases has inspired scientists to focus on antivirulence factors instead of the microorganisms themselves. In this respect, prior work indicates that tiny, enclosed bilayer lipid membranes (liposomes) have the potential to compete with cellular targets for toxin binding, hence preventing their biological attack and aiding with their clearance. The effectiveness of liposomes as decoy targets depends on their availability in the host and how rapidly they are cleared from the circulation. Although liposome PEGylation may i

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Asensio-Regalado, Carlos, Rosa María Alonso-Salces, Blanca Gallo, et al. "A Liposomal Formulation to Exploit the Bioactive Potential of an Extract from Graciano Grape Pomace." Antioxidants 11, no. 7 (2022): 1270. http://dx.doi.org/10.3390/antiox11071270.

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Antioxidant compounds with health benefits can be found in food processing residues, such as grape pomace. In this study, antioxidants were identified and quantified in an extract obtained from Graciano red grape pomace via a green process. The antioxidant activity of the extract was assessed by the DPPH and FRAP tests, and the phenolic content by the Folin–Ciocalteu test. Furthermore, nanotechnologies were employed to produce a safe and effective formulation that would exploit the antioxidant potential of the extract for skin applications. Anthocyanins, flavan-3-ols and flavanols were the mai

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Uchida, Tsutomu, Masafumi Nagayama, Kenji Yamazaki, Kazutoshi Gohara, and Amadeu K. Sum. "Raman spectra measurements on DEPC liposome and cell membrane of living neuron under xenon pressure." Canadian Journal of Chemistry 93, no. 8 (2015): 831–38. http://dx.doi.org/10.1139/cjc-2014-0542.

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The Raman spectra of liposomes were measured under xenon pressures and low temperatures to observe the spectra changes accompanying the gel to liquid crystalline phase transition of the liposomes. C–H stretching bonds of the lipids in the liposome were slightly red shifted at approximately 285 K and atmospheric pressure, which coincided well with the phase transition condition. This Raman peak shift was observed at lower temperatures and related linearly to the xenon pressures. The xenon pressure dependence on the phase transition temperature was in good agreement with the DSC measurements, an

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Zhang, Lan, Melina A. Agosto, Tijana Ivanovic, David S. King, Max L. Nibert та Stephen C. Harrison. "Requirements for the Formation of Membrane Pores by the Reovirus Myristoylated μ1N Peptide". Journal of Virology 83, № 14 (2009): 7004–14. http://dx.doi.org/10.1128/jvi.00377-09.

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ABSTRACT The outer capsid of the nonenveloped mammalian reovirus contains 200 trimers of the μ1 protein, each complexed with three copies of the protector protein σ3. Conformational changes in μ1 following the proteolytic removal of σ3 lead to release of the myristoylated N-terminal cleavage fragment μ1N and ultimately to membrane penetration. The μ1N fragment forms pores in red blood cell (RBC) membranes. In this report, we describe the interaction of recombinant μ1 trimers and synthetic μ1N peptides with both RBCs and liposomes. The μ1 trimer mediates hemolysis and liposome disruption under

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Л. В. Иванов, А. В. Щербак, В. Г. Кравченко, Л. В. Деримедведь та Э. В. Супрун. "ИЗУЧЕНИЕ МЕХАНИЗМОВ РАСШИРЕНИЯ СПЕКТРА ЦИТОТОКСИЧНОСТИ ПЕГИЛИРОВАННЫХ ЛИПОСОМАЛЬНЫХ СИСТЕМ ДОСТАВКИ ПРОТИВООПУХОЛЕВЫХ ПРЕПАРАТОВ МЕТОДОМ СПИНОВЫХ ЗОНДОВ". World Science 3, № 6(46) (2019): 26–36. http://dx.doi.org/10.31435/rsglobal_ws/30062019/6573.

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    Pegylated liposomal anticancer drugs, in particular, doxorubicin have an expansion of the spectrum of toxicity. To study the mechanisms of influence of polyethylene glycol (PEG) on the structure of cell membranes, the sensitive biophysical method of spin probes was used. Using the spin probe method, it has been shown that in the presence of an increased prothrombin blood index, increased blood viscosity and a high density of red blood cells and other blood components, large and long fragments of PEG molecules located on the surface of pegylated liposomal delivery sy

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Long, Pengcheng, Lisha Zhu, Huafa Lai, et al. "Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity." Foods 12, no. 3 (2023): 447. http://dx.doi.org/10.3390/foods12030447.

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Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to improve stability in this study. Monascus red pigments liposomes (MRPL) exhibited spherical unilamellar vesicles (UV) with particle size, polydispersity indexes (PDI), and zeta potential of 20–200 nm, 0.362 ± 0.023, and −42.37 ± 0.21 mV, respectively. pH, thermal, light, metal ion, storage, and in vitr

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Silva, Franciéle M., Jaqueline R. Silva, Wellington Rodrigues, et al. "Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing." Pharmaceuticals 18, no. 7 (2025): 1067. https://doi.org/10.3390/ph18071067.

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Background: Wound healing in diabetic individuals is a prolonged process, often complicated by infections and impaired tissue regeneration. Innovative strategies combining natural bioactive compounds are needed to enhance repair. Methods: This study reports the development and characterization of natural latex-based biomembranes (NLBs) incorporated with liposome-encapsulated curcumin and papain. The therapeutic efficacy of these composite dressings, in combination with red light-emitting diode (LED) phototherapy, was evaluated in a diabetic rat model. NLBs were produced by blending natural lat

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Pillai Babu, Sethu Parvathy, RavI Rajagopalan Reshma, S. Rohan Sunil, R. Munisankar Sharathkumar, and Anand Thiyagaraj. "Biocompatible and sustained delivery of cinnamic acid using liposomal formulation." Research Journal of Biotechnology 19, no. 5 (2024): 9–21. http://dx.doi.org/10.25303/1905rjbt09021.

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Cinnamic acid is an aromatic polyphenolic natural bioactive ingredient in ginseng, wheat, grains and cinnamon bark, among other substances. It is widely used in the manufacture of cosmetics, perfumes and as a flavor enhancer in the food industry. In recent years, cinnamic acid has been reported to have a variety of antibacterial, anticancer, anti-inflammatory and neuroprotective properties. Liposomes are lipid-based nanoparticles that have received considerable attention in drug delivery research due to their strong biocompatibility and low toxicity. Their resistance to degradation, as well as

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Menchinskaya, Ekaterina S., Vladimir I. Gorbach, Evgeny A. Pislyagin, et al. "Interaction of Liposomes Containing the Carrageenan/Echinochrome Complex with Human HaCaT Keratinocytes In Vitro." Marine Drugs 22, no. 12 (2024): 561. https://doi.org/10.3390/md22120561.

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Liposomal drug delivery systems are successfully used in various fields of medicine for external and systemic applications. Marine organisms contain biologically active substances that have a unique structure and exhibit a wide range of biological activities. Polysaccharide of red seaweed (carrageenan (CRG)), and water-insoluble sea urchin pigment (echinochrome (Ech)) interact with each other and form a stable complex. We included the CRG/Ech complex in liposomes for better permeability into cells. In our research, tetramethylrhodamine isothiocyanate TRITC-labeled CRG was synthesized to study

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Moussa, Marwan, Md Raihan Chowdhury, David Mwin, et al. "Combined thermal ablation and liposomal granulocyte-macrophage colony stimulation factor increases immune cell trafficking in a small animal tumor model." PLOS ONE 18, no. 10 (2023): e0293141. http://dx.doi.org/10.1371/journal.pone.0293141.

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Purpose To characterize intratumoral immune cell trafficking in ablated and synchronous tumors following combined radiofrequency ablation (RFA) and systemic liposomal granulocyte-macrophage colony stimulation factor (lip-GM-CSF). Methods Phase I, 72 rats with single subcutaneous R3230 adenocarcinoma were randomized to 6 groups: a) sham; b&c) free or liposomal GM-CSF alone; d) RFA alone; or e&f) combined with blank liposomes or lip-GM-CSF. Animals were sacrificed 3 and 7 days post-RFA. Outcomes included immunohistochemistry of dendritic cells (DCs), M1 and M2 macrophages, T-helper cells

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Salminen, H., R. Kivikari, and M. Heinonen. "Protein-lipid interactions during oxidation of liposomes." Czech Journal of Food Sciences 22, SI - Chem. Reactions in Foods V (2004): S133—S135. http://dx.doi.org/10.17221/10636-cjfs.

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Oxidation of bovine serum albumin and its interaction with phenolic red raspberry and bilberry extracts (4.2 and 8.4 μg/ml) was investigated in a liposome system. Samples were incubated in the dark at 37°C with copper, and the extent of oxidation was measured by determing the loss of tryptophan fluorescence and the formation of protein carbonyls, conjugated diene hydroperoxides and hexanal. Both red raspberry and bilberry extracts inhibited lipid and protein oxidation. Red raspberry extract in 4.2 μg/ml concentration was the best inhibitor against both lipid and protein oxidation. In conclusio

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Zulkeffleey, Shafyrna, Wan Azman Wan Ismail, and Kashif Shakeel. "A Review on Resveratrol-loaded Liposome and Its Characterisation." International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science 4 (June 30, 2021): 58–75. http://dx.doi.org/10.24191/ijpnacs.v4.05.

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Resveratrol (3,5,4′-trihydroxystilbene) is a stilbene-type natural polyphenol found in a variety of plant species, including grapes, berries, peanuts, and red wine. Many studies have demonstrated that resveratrol as a nutraceutical supplement, exhibits numerous pharmacological properties such as antioxidant, anti-inflammatory, cardio-protective, neuroprotective, chemo-preventive, and anti-aging. Despite its health-beneficial effects, resveratrol has extremely low water solubility, high absorption, and rapid metabolism that consequently reduces its oral bioavailability. Hence, there have been a

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Phillips, NC, and C. Tsoukas. "Liposomal encapsulation of azidothymidine results in decreased hematopoietic toxicity and enhanced activity against murine acquired immunodeficiency syndrome." Blood 79, no. 5 (1992): 1137–43. http://dx.doi.org/10.1182/blood.v79.5.1137.1137.

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Abstract This study has determined the effect of liposomal encapsulation on the hematopoietic toxicity and antiviral activity of 3′-azido-3′- deoxythymidine (AZT) in mice. Daily intravenous administration in the dose range 0.4 to 10 mg/kg body weight for 5 days significantly depressed bone marrow cellularity with a corresponding decrease in red blood cell, blood neutrophil, and monocyte numbers. Maximum toxicity was seen at 2 mg/kg or greater. Liposomal encapsulation of AZT and administration at 2 mg/kg abrogated the toxicity of AZT. The neutrophil inflammatory response to thioglycollate injec

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Phillips, NC, and C. Tsoukas. "Liposomal encapsulation of azidothymidine results in decreased hematopoietic toxicity and enhanced activity against murine acquired immunodeficiency syndrome." Blood 79, no. 5 (1992): 1137–43. http://dx.doi.org/10.1182/blood.v79.5.1137.bloodjournal7951137.

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This study has determined the effect of liposomal encapsulation on the hematopoietic toxicity and antiviral activity of 3′-azido-3′- deoxythymidine (AZT) in mice. Daily intravenous administration in the dose range 0.4 to 10 mg/kg body weight for 5 days significantly depressed bone marrow cellularity with a corresponding decrease in red blood cell, blood neutrophil, and monocyte numbers. Maximum toxicity was seen at 2 mg/kg or greater. Liposomal encapsulation of AZT and administration at 2 mg/kg abrogated the toxicity of AZT. The neutrophil inflammatory response to thioglycollate injected intra

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Moya-Garcia, Christian R., Nicole Y. K. Li-Jessen, and Maryam Tabrizian. "Chitosomes Loaded with Docetaxel as a Promising Drug Delivery System to Laryngeal Cancer Cells: An In Vitro Cytotoxic Study." International Journal of Molecular Sciences 24, no. 12 (2023): 9902. http://dx.doi.org/10.3390/ijms24129902.

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Current delivery of chemotherapy, either intra-venous or intra-arterial, remains suboptimal for patients with head and neck tumors. The free form of chemotherapy drugs, such as docetaxel, has non-specific tissue targeting and poor solubility in blood that deters treatment efficacy. Upon reaching the tumors, these drugs can also be easily washed away by the interstitial fluids. Liposomes have been used as nanocarriers to enhance docetaxel bioavailability. However, they are affected by potential interstitial dislodging due to insufficient intratumoral permeability and retention capabilities. Her

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Yu, Darrick L., Natalie S. M. Chow, Byram W. Bridle, and Sarah K. Wootton. "Macrophage Depletion via Clodronate Pretreatment Reduces Transgene Expression from AAV Vectors In Vivo." Viruses 13, no. 10 (2021): 2002. http://dx.doi.org/10.3390/v13102002.

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Adeno-associated virus is a popular gene delivery vehicle for gene therapy studies. A potential roadblock to widespread clinical adoption is the high vector doses required for efficient transduction in vivo, and the potential for subsequent immune responses that may limit prolonged transgene expression. We hypothesized that the depletion of macrophages via systemic delivery of liposome-encapsulated clodronate would improve transgene expression if given prior to systemic AAV vector administration, as has been shown to be the case with adenoviral vectors. Contrary to our expectations, clodronate

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Deng, C., Y. Chen, X. Zhao, et al. "POS0330 SYNOVIAL M1 MACROPHAGES AND FIBROBLASTS DUAL-TARGETING LIPOSOMES ASSISTED DELIVERY OF TRIAMCINOLONE ACETONIDE IS EFFECTIVE AGAINST JOINT PAIN AND CARTILAGE DEGENERATION IN OSTEOARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 411.1–411. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4341.

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BackgroundThe latest professional guidelines recommend intra-articular (IA) glucocorticoids (GCs) for pain relief in patients with knee osteoarthritis (OA). However, their effect is small-to-moderate and short-term only[1]. There is also concern about the possible risk of cartilage deterioration caused by repeated IA GCs. M1 macrophages and activated synovial fibroblasts (SFs) mutually contribute to the propagation of joint pain and cartilage destruction in OA by constructing a positive feedback loop. To alleviate joint pain more effectively over a longer period without increasing the risk of

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Krivić, Hannah, Sebastian Himbert, and Maikel C. Rheinstädter. "Perspective on the Application of Erythrocyte Liposome-Based Drug Delivery for Infectious Diseases." Membranes 12, no. 12 (2022): 1226. http://dx.doi.org/10.3390/membranes12121226.

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Nanoparticles are explored as drug carriers with the promise for the treatment of diseases to increase the efficacy and also reduce side effects sometimes seen with conventional drugs. To accomplish this goal, drugs are encapsulated in or conjugated to the nanocarriers and selectively delivered to their targets. Potential applications include immunization, the delivery of anti-cancer drugs to tumours, antibiotics to infections, targeting resistant bacteria, and delivery of therapeutic agents to the brain. Despite this great promise and potential, drug delivery systems have yet to be establishe

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Krylova, Natalia V., Vladimir I. Gorbach, Olga V. Iunikhina, et al. "Antiherpetic Activity of Carrageenan Complex with Echinochrome A and Its Liposomal Form." International Journal of Molecular Sciences 23, no. 24 (2022): 15754. http://dx.doi.org/10.3390/ijms232415754.

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Herpes simplex virus (HSV) infections, the incidence of which is still widespread throughout the world, are actualizing the search and development of new, more effective antiherpetic drugs. The development of multifunctional drug delivery systems, including liposome-based ones, has become a relevant and attractive concept in nanotechnology. The ability of complexes of κ- and Σ-carrageenans (CRGs)—sulfated polysaccharides of red algae, with echinochrome A (Ech), as well as the liposomal form of the Σ-CRG/Ech complex—to inhibit different stages of HSV-1 infection in Vero cells was studied. By qu

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Rudolph, Alan S., Anthony Sulpizio, Paul Hieble, Victor Macdonald, Mark Chavez, and Giora Feuerstein. "Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments." Journal of Applied Physiology 82, no. 6 (1997): 1826–35. http://dx.doi.org/10.1152/jappl.1997.82.6.1826.

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Rudolph, Alan S., Anthony Sulpizio, Paul Hieble, Victor Macdonald, Mark Chavez, and Giora Feuerstein. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. J. Appl. Physiol.82(6): 1826–1835, 1997.—Free hemoglobin (Hb) induces a potent vasoconstrictor response that may limit its therapeutic application as a red blood cell replacement. We have investigated whether encapsulation of stroma-free Hb (SFHb) or cross-linked Hb (αα-Hb) in liposomes modulates Hb vasoactivity in isolated blood vessels. Relaxation of rabbit thoracic vessels was measured before

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Xu, Qin, Mengran Guo, Xiaodong Jin, et al. "Interferon Regulatory Factor 5 siRNA-Loaded Folate-Modified Cationic Liposomes for Acute Lung Injury Therapy." Journal of Biomedical Nanotechnology 17, no. 3 (2021): 466–76. http://dx.doi.org/10.1166/jbn.2021.3046.

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Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an overwhelming pulmonary inflammation with limited clinical treatment strategies. Interferon regulatory factor 5 (IRF5) is a crucial regulator of inflammation factors, which can be upregulated under an inflammatory state and related to the efferocytosis of macrophages. Herein, IRF5 was knockdown by small interfering RNA (siIRF5) to promote the anti-inflammatory effect of macrophages. Macrophage-targeting cationic liposome modified by folate (FA-LP) was developed to deliver siIRF5 (FA-LP/siIRF5). Liposomes were characterized f

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