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Dissertations / Theses on the topic 'Ribosomes. Proteins Eukaryotic cells'

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Published: 4 June 2021

Last updated: 9 February 2022

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1

Rozen, Florence. "Identification and role of cap binding proteins in eukaryotic cells." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74247.

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All eukaryotic cellular mRNAs (except for organelle mRNAs) are blocked at their 5$ sp prime$ end by the cap structure m$ sp7$GpppX (where X = any nucleotide). The cap structure plays a multifunctional role in both the nucleus and the cytoplasm. Two polypeptides of molecular mass of 20 and 115 kDa in HeLa nuclear extracts were shown to recognize and be crosslinked to the cap structure of eukaryotic mRNAs in a cap-dependent fashion. Their cap binding properties have been characterized, although their function in the nucleus is unknown. Previous studies have shown that cap function in the cytopla

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2

Metz, Anneke Maria. "Function of the wheat eukaryotic initiation factors eIF(ISO)4G and eIF4B in translation /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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3

Chen, Lu-hua. "Evaluation of eIF-2 alpha phosphorylation in patients with Alzheimer's disease /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38284273.

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4

Hui, Daniel Jason. "The Mechanism of Protein Synthesis Inhibition by the P56 Family of Viral Stress Inducible Proteins." Connect to text online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1104848977.

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5

Tang, Terry, and University of Lethbridge Faculty of Arts and Science. "Mathematical modeling of eukaryotic gene expression." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, 2010, 2010. http://hdl.handle.net/10133/2567.

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Using the Gillespie algorithm, the export of the mRNA molecules from their transcription site to the nuclear pore complex is simulated. The effect of various structures in the nu- cleus on the efficiency of export is discussed. The results show that having some of the space filled by chromatin near the mRNA synthesis site shortens the transport time. Next, the complete eukaryotic gene expression including transcription, splicing, mRNA export, translation, and mRNA degradation is modeled using delay stochastic simulation. This allows for the study of stochastic effects during the process and on

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6

Quynh, Tran Hoang Thi. "Identification and functional characterization of trans-acting factors required for eukaryotic ribosome synthesis." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210540.

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Eukaryotic ribosome synthesis is a complex process that consumes a lot of energy and involves several hundreds of trans-acting factors that transiently associate with nascent ribosomes. Biogenesis of ribosomal subunits (the small 40S and the large 60S) starts with transcription of a long precursor ribosomal RNA (pre-rRNA) by RNA polymerase I (Pol I) in the nucleolus. This is a key step that globally controls yeast ribosome synthesis. The pre-rRNA, ‘the 35S transcript’, encodes the mature sequence (18S, 5.8S, and 25S) rRNA constituents of both the 40S and 60S subunits. The 35S transcript is sub

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7

Leon, Ronald P. "Structural and functional analysis of MCM helicases in eukaryotic DNA replication /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biophysics & Genetics, Program in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 90-98). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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8

Wen, Wenyu. "Structural characterization of proteins involved in cellular signaling and trafficking /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BICH%202008%20WEN.

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9

Chen, Lu-hua, та 陳璐華. "Evaluation of eIF-2α phosphorylation in patients with Alzheimer's disease". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011151.

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10

Lavoie, Cynthia. "The molecular and biochemical characterization of proteins involved in translation initiation in Drosophila melanogaster." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29072.

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A preliminary analysis of translation initiation has been carried out using the model system Drosophila melanogaster. These efforts have focussed on identifying the homolog of mammalian of mammalian eIF-4F, a complex of three subunits; eIF-4E which binds the mRNA cap, eIF-4A which has ATP-dependent RNA helicase activity, and eIF-4$ gamma$, of unknown function. Attempts to clone the genes encoding subunits of eIF-4F have led to the isolation of two novel genes. A molecular screen for members of the DEAD family of RNA helicases that includes eIF-4A led to the isolation of a gene which encodes th

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11

SILVA, FLAVIO S. "Clonagem, expressão, purificação e caracterização estrutural da região AP-1 da oncoproteína Jun." reponame:Repositório Institucional do IPEN, 2014. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11802.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2014-11-10T11:41:14Z No. of bitstreams: 0<br>Made available in DSpace on 2014-11-10T11:41:14Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado em Tecnologia Nuclear)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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12

Bruinsma, Paul. "The role of the yeast COG3, VPS35, and YDR141C proteins in membrane trafficking /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074381.

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13

Rutherford, Sharon Ann. "Construction of a single-chain antibody against intermediate filaments." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68253.

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Intermediate filaments are fibrous proteins, appearing in a wide variety of tissue specific forms. The function of these proteins is poorly understood, although they are commonly believed to perform a structural role in the cell. Evidence suggests that the role these proteins play may be more dynamic than was previously believed. To gain more insight into their normal in vivo function, a single-chain monoclonal antibody has been constructed to serve as a specific reagent which can disrupt the intermediate filament network in vivo. The work presented in this thesis represents the first step in

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14

Tai, Chi Shing. "Identification and characterization of Vps74p, a coatomer and SNARE interacting protein involved in membrane traffic /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202004%20TAI.

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15

Linka, Marc. "Understanding the origin and function of organellar metabolite transport proteins in photosynthetic eukaryotes Galdieria sulphuraria and Arabidopsis thaliana as model systems /." Diss., Connect to online resource - MSU authorized users, 2008.

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16

Kanwal, Sajida [Verfasser]. "Delineating the interaction of pneumococcal virulence factors with host eukaryotic cells mediated by matricellular proteins fibronectin and vitronectin / Sajida Kanwal." Greifswald : Universitätsbibliothek Greifswald, 2017. http://d-nb.info/1147519927/34.

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17

Meijer, Lisa. "Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-560-3/.

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18

Charlton, Jane Laura. "Understanding the biomolecular interactions involved in dimerisation of the Saccharomyces cerevisiae eukaryotic translation initiation factor 5A." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004118.

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Translation initiation factor 5A (IF5A) is an essential, highly conserved protein found within all eukaryotic (eIF5A) and archaeal (aIF5A) cells. The IF5A protein is unique in that it contains the amino acid hypusine; a two-step post translational modification of a single, conserved lysine residue. Although hypusination of eIF5A is vital for eukaryotic cell viability, the primary role of the protein and its hypusine side chain remain a mystery. eIF5A, initially identified as a translation initiation factor, is not required for global protein synthesis leading to the prevailing proposal that eI

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19

Doughty, Tyler W. "Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/861.

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For nearly five decades, the simple eukaryote Saccharomyces cerevisiae has been used as a model for understanding the eukaryotic cell cycle. One vein of this research has focused on understanding how chromosome structure is regulated in relation to the cell cycle. This work characterizes a new mechanism that modulates the chromatin organizing condensin complex, in hopes of furthering the understanding of chromosome structure regulation in eukaryotes. During mitosis, chromosomes are condensed to facilitate their segregation through a process mediated by the condensin complex. Upon interphase on

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20

Doughty, Tyler W. "Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/861.

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For nearly five decades, the simple eukaryote Saccharomyces cerevisiae has been used as a model for understanding the eukaryotic cell cycle. One vein of this research has focused on understanding how chromosome structure is regulated in relation to the cell cycle. This work characterizes a new mechanism that modulates the chromatin organizing condensin complex, in hopes of furthering the understanding of chromosome structure regulation in eukaryotes. During mitosis, chromosomes are condensed to facilitate their segregation through a process mediated by the condensin complex. Upon interphase on

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21

Llinares, Elisa. "Function, regulation and intracellular trafficking of the vacuolaryeast pq-loop (Ypq) proteins." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209704.

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The cytoplasm of eukaryotic cells contains several membrane-delimited compartments of specific molecular compositions and functions. Among those, the vacuole of fungal cells is often described as an organelle equivalent to the lysosomes of animal cells and the vacuoles of plant cells. These compartments indeed share two similar features: they contain a wide variety of hydrolases and are the most acidic compartments of the cell, which accounts for their key role in the intracellular degradation of macromolecules. In humans, dysfunctions of the lysosomes often give rise to lysosomal related dise

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22

Thoring, Lena [Verfasser], Stefan [Akademischer Betreuer] Kubick, Juri [Gutachter] Rappsilber, Roland [Gutachter] Lauster, and Stefan [Gutachter] Kubick. "Development of eukaryotic cell-free systems based on Chinese hamster ovary cells for the production of "difficult-to-express" proteins / Lena Thoring ; Gutachter: Juri Rappsilber, Roland Lauster, Stefan Kubick ; Betreuer: Stefan Kubick." Berlin : Technische Universität Berlin, 2018. http://d-nb.info/1164076558/34.

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23

Kiesler, Eva. "Isolation and functional characterization of Hrp65-binding proteins in Chironomus tentans." Doctoral thesis, Stockholm : Institutionen för molekylärbiologi och funktionsgenomik, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-218.

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24

Yazdani, Laura. "Étude de l'impact de l'activité traductionnelle sur le phénotype tumoral dans le cancer du côlon." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT031/document.

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Avec près d’un million de nouveaux cas par an à travers le monde, le cancer colorectal est un problème de santé publique majeur. Il est la 2ème cause de mortalité par cancer en France, ce fort taux de mortalité étant relié à un pourcentage important de récidives et de métastases. L’hétérogénéité tumorale, la dissémination, la résistance aux traitements et la récidive seraient notamment dues à une population particulière de cellules tumorales appelées cellules souches cancéreuses (CSC). Ces cellules sont dotées d’une capacité d’adaptation extraordinaire et la compréhension des mécanismes molécu

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25

Farfán, Arribas Diego José. "On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/589.

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Peptides generated from cellular protein degradation via the ubiquitin-proteasome pathway are presented on MHC class I as a means for the immune system to monitor polypeptides being synthesized by cells. For CD8 + T cells to prevent the spread of an incipient infection, it appears essential they should be able to sense foreign polypeptides being synthesized as soon as possible. A prompt detection of viral proteins is of great importance for the success of an adaptive immune response. Defective ribosomal products (DRiPs) have been postulated as a preferential source which would allow for a rapi

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26

Sun, Lele. "Peptidyltransfer Reaction Catalyzed by the Ribosome and the Ribozyme: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/115.

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The "RNA world" hypothesis makes two predictions that RNA should have been able both to catalyze RNA replication and to direct protein synthesis. The evolution of RNA-catalyzed protein synthesis should be critical in the transition from the RNA world to the modem biological systems. Peptide bond formation is a fundamental step in modem protein biosynthesis. Although many evidence suggests that the ribosome is a ribozyme, peptide bond formation has not been achieved with ribosomal RNAs only. The goal of this thesis is to investigate whether RNA could catalyze peptide bond formation and how RNA

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27

West, Matthew Blaine. "Nmd3p, the nuclear export adapter for the 60S ribosomal subunit: characterization of its recycling mechanism and novel interaction with the nuclear pore complex in yeast." Thesis, 2005. http://hdl.handle.net/2152/2367.

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28

Ramírez, Reyes del Campillo Maria Celia. "Ribosomal protein genes in the extreme thermophilic archaebacterium sulfolobus solfataricus." Thesis, 1990. https://dspace.library.uvic.ca//handle/1828/9470.

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Six ribosomal protein genes from the sulfur dependent extreme thermophilic archaebacterium Sulfolobus solfataricus were cloned and sequenced. Four of these genes code for proteins that are equivalent to ribosomal proteins L11, L1, L10 and L12 in Escherichia coli. The other two genes code for proteins that have no equivalent in the eubacteria. The product of one of these genes was found to be equivalent to ribosomal proteins L46 from yeast (Leer et al. 1985a) and L39 from rat liver (Lin et al. 1984), while the product of the other gene shows no sequence similarity to any of the ribosomal protei

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29

Kallstrom, George Harvester. "Defining the late 60S ribosomal subunit maturation pathway from the nucleolus to the cytoplasm." 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3101216.

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30

Reid, David William. "Segregation of Protein Synthesis Between the Cytoplasm and Endoplasmic Reticulum of Eukaryotic Cells." Diss., 2014. http://hdl.handle.net/10161/8752.

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<p>The partitioning of translation to the outer membrane of the endoplasmic reticulum is a problem that has been the subject of inquiry since the discovery of the ribosome. The large degree to which ribosomes were found to be tethered to the membrane led to intense investigation of a series of related questions regarding the identity of those mRNAs that are translated on the endoplasmic reticulum, and the functions of that localization in cell stress. In this dissertation, I approach each of these questions in turn and work to reconcile my observations with those models that have been previous

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31

Chi, Hsiao-Lan, and 紀筱嵐. "Nuclear Import of Eukaryotic Ribosomal Proteins: Cellular trafficking of human ribosomal protein L10 between the cell nucleus and the plasma membrane." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/89076727203258272443.

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碩士<br>國立陽明大學<br>生命科學暨基因體科學研究所<br>95<br>In the eukaryotic ribosome biogenesis, the ribosomal proteins must be imported into the nucleus for assembly. In general, proteins which are capable of entering the nucleus usually contain a nuclear localization signal (NLS). In this study, we first used all available NLS prediction programs to search the presence of NLS in all eukaryotic ribosomal proteins, and found RPS4, RPS20, RPL10, RPL17, RPL18 and RPL31 do not contain any predicted NLS. To verify the nature of such ribosomal proteins, we used a flag-tagging approach to see whether these proteins ar

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32

Elebo, Nnenna Chioma. "Biophysical characterisation of human eukaryotic elongation factor 1 Beta and its interaction with human eukaryotic elongation factor 1 Gamma." Thesis, 2017. https://hdl.handle.net/10539/24023.

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A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. July, 2017<br>Eukaryotic protein synthesis occurs in three phases: initiation, elongation and termination. The elongation phase is mediated by elongation factors. Elongation factors are divided into elongation factor 1 (eEF1) and elongation factor 2 (eEF2). Elongation factor 1 complex are proteins that mediates the extension of growing polypeptide chains by adding one amino acid residue at a time. The eEF-1 complex comprises

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33

Neupane, Ritam. "How to steal ribosomes: structural studies of two different internal ribosome entry sites." Thesis, 2021. https://doi.org/10.7916/d8-es0b-bj41.

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Taking control of the protein production machinery of the host cell is a required step in the life cycle of viruses. Towards this end, viruses have evolved diverse strategies of cellular mimicry and deception to hijack and steal host cell ribosomes for viral protein production. In higher eukaryotes, where translation is sophisticated and access to ribosomes intricately regulated, numerous positive strand RNA viruses have evolved structured RNA sequences to evade translation regulation mechanisms. These RNA sequences, called Internal Ribosomal Entry Sites (IRESs), use their RNA structure to hij

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34

Altomare, Clara Gilda. "Structural Studies of NediV-IRES-Mediated Translation Initiation." Thesis, 2021. https://doi.org/10.7916/d8-g12a-ed94.

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Viruses require a host cell to replicate and proliferate; upon infection they appropriate host resources and molecular machines. Specifically, viruses use ribosomes of the host to translate the information in their genome. Some viruses with single-stranded RNA genomes contain highly structured non-coding regions of RNA called internal ribosome entry sites (IRESs) which are used to hijack the host’s ribosomes through a non-canonical cap-independent initiation pathway. Canonical translation initiation is a highly complex and regulated process: at least a dozen translation factors are necessary,

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35

Matragrano, Joseph Antonio. "Engineering yeast G protein-coupled receptors for biosensor development." Thesis, 2020. https://doi.org/10.7916/d8-dyv1-7e24.

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The ability to sense and respond to environmental stimuli is essential for the survival of all living things. As a result, nature has evolved an uncountable number of ways to detect environmental signals. At the cellular level, G protein-coupled receptors (GPCRs) are used by eukaryotes, including fungi and humans, to convert extracellular molecular binding events into intracellular responses. Recently, synthetic biologists have shown that biological sensing systems can be repurposed to suit human needs, developing tools such as diagnostic devices and drug screening platforms. In this thesis, I

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36

Pike, Schuyler Todd 1966. "Characterization of mitochondrial C₁-tetrahydrofolate synthase transcript and protein expression in adult and embryonic mammalian tissues and the role of the mitochondrial one-carbon pathway in the cytoplasmic methyl cycle." 2008. http://hdl.handle.net/2152/18094.

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In eukaryotes, folate-dependent one-carbon (1-C) metabolism is composed of two parallel pathways compartmentalized to either the cytoplasm or mitochondria. In each, 1-C units, carried on tetrahydrofolate (THF), are interconverted by four catalytic activities. Serine hydroxymethyltransferase transfers the 3-carbon of serine to THF forming 5,10-methylene-THF which is oxidized in 3 successive steps to formate via the intermediates, 5,10-methenyl-THF and 10-formyl-THF. Because of the redox potential in each compartment, 1-C flux is thought by most authors to be from formate to serine in the cytoso

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37

Tumia, Rima Ahmed N. Hashm. "Role of eIF3a expression in cellular sensitivity to ionizing radiation treatments by regulating synthesis of NHEJ repair proteins." Thesis, 2015. http://hdl.handle.net/1805/9767.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Translation Initiation in protein synthesis is a crucial step controlling gene expression that enhanced by eukaryotic translation initiation factors (eIFs). eIF3a, the largest subunit of eIF3 complexes, has been shown to regulate protein synthesis and cellular response to cisplatin treatment. Its expression has also been shown to negatively associate with prognosis. In this study, we tested a hypothesis that eIF3a regulates synthesis of proteins important for repair of double strand DNA breaks induced by ionizing radiation (IR). We

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38

Plummer, Kevin D. "CHARACTERIZATION OF THE MDM2 BINDING REGIONS OF RIBOSOMAL PROTEIN L5." Thesis, 2010. http://hdl.handle.net/1805/2203.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The MDM2-p53 feedback loop is a well-characterized pathway. p53 is a transcription factor and regulates the transcriptional expression of genes that encode proteins responsible for cellular senescence, cell cycle arrest, apoptosis, and DNA repair. Various cellular stresses can result in p53 activation, including hypoxia, DNA damage by agents such as UV or IR, oncogenic signaling, nucleotide depletion and nucleolar stress from perturbation of ribosomal biogenesis. Under normal conditions, MDM2’s role in the pathway is to inhibi

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39

Dey, Souvik. "Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation." Thesis, 2012. http://hdl.handle.net/1805/3041.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>In response to different environmental stresses, phosphorylation of eIF2 (eIF2P) represses global translation coincident with preferential translation of ATF4. ATF4 is a transcriptional activator of the integrated stress response, a program of gene expression involved in metabolism, nutrient uptake, anti-oxidation, and the activation of additional transcription factors, such as CHOP/GADD153, that can induce apoptosis. Although eIF2P elicits translational control in response to many different stress arrangements, there are selecte

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