Academic literature on the topic 'RNA dependent DNA methylation'

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Journal articles on the topic "RNA dependent DNA methylation"

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Wendte, Jered M., Jeremy R. Haag, Olga M. Pontes, Jasleen Singh, Sara Metcalf, and Craig S. Pikaard. "The Pol IV largest subunit CTD quantitatively affects siRNA levels guiding RNA-directed DNA methylation." Nucleic Acids Research 47, no. 17 (2019): 9024–36. http://dx.doi.org/10.1093/nar/gkz615.

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Abstract In plants, nuclear multisubunit RNA polymerases IV and V are RNA Polymerase II-related enzymes that synthesize non-coding RNAs for RNA-directed DNA methylation (RdDM) and transcriptional gene silencing. Here, we tested the importance of the C-terminal domain (CTD) of Pol IV’s largest subunit given that the Pol II CTD mediates multiple aspects of Pol II transcription. We show that the CTD is dispensable for Pol IV catalytic activity and Pol IV termination-dependent activation of RNA-DEPENDENT RNA POLYMERASE 2, which partners with Pol IV to generate dsRNA precursors of the 24 nt siRNAs
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Zhong, Xuehua, Christopher J. Hale, Minh Nguyen, et al. "DOMAINS REARRANGED METHYLTRANSFERASE3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis." Proceedings of the National Academy of Sciences 112, no. 3 (2015): 911–16. http://dx.doi.org/10.1073/pnas.1423603112.

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DNA methylation is a mechanism of epigenetic gene regulation and genome defense conserved in many eukaryotic organisms. In Arabidopsis, the DNA methyltransferase DOMAINS REARRANGED METHYLASE 2 (DRM2) controls RNA-directed DNA methylation in a pathway that also involves the plant-specific RNA Polymerase V (Pol V). Additionally, the Arabidopsis genome encodes an evolutionarily conserved but catalytically inactive DNA methyltransferase, DRM3. Here, we show that DRM3 has moderate effects on global DNA methylation and small RNA abundance and that DRM3 physically interacts with Pol V. In Arabidopsis
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Taochy, Christelle, Agnès Yu, Nicolas Bouché, et al. "Post-transcriptional gene silencing triggers dispensable DNA methylation in gene body in Arabidopsis." Nucleic Acids Research 47, no. 17 (2019): 9104–14. http://dx.doi.org/10.1093/nar/gkz636.

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Abstract Spontaneous post-transcriptional silencing of sense transgenes (S-PTGS) is established in each generation and is accompanied by DNA methylation, but the pathway of PTGS-dependent DNA methylation is unknown and so is its role. Here we show that CHH and CHG methylation coincides spatially and temporally with RDR6-dependent products derived from the central and 3′ regions of the coding sequence, and requires the components of the RNA-directed DNA methylation (RdDM) pathway NRPE1, DRD1 and DRM2, but not CLSY1, NRPD1, RDR2 or DCL3, suggesting that RDR6-dependent products, namely long dsRNA
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Rao, Xiaolan, Shengli Yang, Shiyou Lü, and Pingfang Yang. "DNA Methylation Dynamics in Response to Drought Stress in Crops." Plants 13, no. 14 (2024): 1977. http://dx.doi.org/10.3390/plants13141977.

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Drought is one of the most hazardous environmental factors due to its severe damage on plant growth, development and productivity. Plants have evolved complex regulatory networks and resistance strategies for adaptation to drought stress. As a conserved epigenetic regulation, DNA methylation dynamically alters gene expression and chromosome interactions in plants’ response to abiotic stresses. The development of omics technologies on genomics, epigenomics and transcriptomics has led to a rapid increase in research on epigenetic variation in non-model crop species. In this review, we summarize
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Lewsey, Mathew G., Thomas J. Hardcastle, Charles W. Melnyk, et al. "Mobile small RNAs regulate genome-wide DNA methylation." Proceedings of the National Academy of Sciences 113, no. 6 (2016): E801—E810. http://dx.doi.org/10.1073/pnas.1515072113.

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RNA silencing at the transcriptional and posttranscriptional levels regulates endogenous gene expression, controls invading transposable elements (TEs), and protects the cell against viruses. Key components of the mechanism are small RNAs (sRNAs) of 21–24 nt that guide the silencing machinery to their nucleic acid targets in a nucleotide sequence-specific manner. Transcriptional gene silencing is associated with 24-nt sRNAs and RNA-directed DNA methylation (RdDM) at cytosine residues in three DNA sequence contexts (CG, CHG, and CHH). We previously demonstrated that 24-nt sRNAs are mobile from
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Wang, Lili, Kezhi Zheng, Longjun Zeng, et al. "Reinforcement of CHH methylation through RNA-directed DNA methylation ensures sexual reproduction in rice." Plant Physiology 188, no. 2 (2021): 1189–209. http://dx.doi.org/10.1093/plphys/kiab531.

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Abstract DNA methylation is an important epigenetic mark that regulates the expression of genes and transposons. RNA-directed DNA methylation (RdDM) is the main molecular pathway responsible for de novo DNA methylation in plants. Although the mechanism of RdDM has been well studied in Arabidopsis (Arabidopsis thaliana), most mutations in RdDM genes cause no remarkable developmental defects in Arabidopsis. Here, we isolated and cloned Five Elements Mountain 1 (FEM1), which encodes RNA-dependent RNA polymerase 2 (OsRDR2) in rice (Oryza sativa). Mutation in OsRDR2 abolished the accumulation of 24
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Zheng, Kezhi, Lili Wang, Longjun Zeng, et al. "The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice." Proceedings of the National Academy of Sciences 118, no. 30 (2021): e2100709118. http://dx.doi.org/10.1073/pnas.2100709118.

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RNA-directed DNA methylation (RdDM) functions in de novo methylation in CG, CHG, and CHH contexts. Here, we performed map-based cloning of OsNRPE1, which encodes the largest subunit of RNA polymerase V (Pol V), a key regulator of gene silencing and reproductive development in rice. We found that rice Pol V is required for CHH methylation on RdDM loci by transcribing long noncoding RNAs. Pol V influences the accumulation of 24-nucleotide small interfering RNAs (24-nt siRNAs) in a locus-specific manner. Biosynthesis of 24-nt siRNAs on loci with high CHH methylation levels and low CG and CHG meth
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Baev, Vesselin, Mladen Naydenov, Elena Apostolova, et al. "Identification of RNA-dependent DNA-methylation regulated promoters in Arabidopsis." Plant Physiology and Biochemistry 48, no. 6 (2010): 393–400. http://dx.doi.org/10.1016/j.plaphy.2010.03.013.

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Wang, Lili, Dachao Xu, Longjun Zeng, and Donglei Yang. "The Rise and Fall of Billionaire siRNAs during Reproductive Development in Rice." Plants 11, no. 15 (2022): 1957. http://dx.doi.org/10.3390/plants11151957.

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RNA polymerase IV-dependent siRNAs, usually 24 nt in length, function in the RNA-directed DNA methylation that is responsible for de novo methylation in plants. We analyzed 24 nt siRNAs in inflorescences and found that among the 20,200 24 nt siRNA clusters, the top 0.81% highly expressed clusters accounted for more than 68% of the 24 nt siRNA reads in inflorescences. We named the highly expressed siRNAs as billionaire siRNAs (bill-siRNAs) and the less-expressed siRNAs as pauper siRNAs (pau-siRNAs). The bill-siRNAs in inflorescences are mainly derived from the ovary. Female gametes produced mor
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Weng, JingRong, JinXin Lin, YuMo Xie, et al. "Abstract 6006: RNA m6A methylation relay the oncogenic flow from DNA methylationto gene expression of ANKRD13B." Cancer Research 83, no. 7_Supplement (2023): 6006. http://dx.doi.org/10.1158/1538-7445.am2023-6006.

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Abstract Background: Colorectal cancer (CRC) is one of the most common causes of cancer-related death in the world. More comprehensive studies of key molecular alterations in CRC progression were urgent. DNA methylation promotes tumor progression. However, the mechanism of the ANKRD13 gene methylation that drives colorectal cancer evolution remains largely unknown. This was the first study focused on the role of ANKRD13 and the hypermethylated mechanisms in colorectal cancer. Methods: Chi-Square tests were utilized to the comparison of the baseline characteristics of patients with hypomethylat
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Dissertations / Theses on the topic "RNA dependent DNA methylation"

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He, Jie. "Isolation of An ARGONAUTE Gene in Pelargonium and Identification Of Candidate Genes Regulated Through ARGONAUTE4-Dependent RNA-Dependent DNA Methylation In Arabidopsis." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1260812913.

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Dissertation (Ph.D.)--University of Toledo, 2009.<br>Typescript. "Submitted as partial fulfillment of the requirements for the Doctor of Philosophy degree in Biology." Bibliography: leaves 54-56, 91-95, 118-119, 133-139.
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Ostler, Jeffery Brent Jr. "Characterization of Pol IV and Pol V-Dependent Non-Coding RNAs Derived from aGeminivirus Genome." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492698361649423.

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Taylor, Laura Margaret. "Aspects of RNA directed DNA methylation in Arabidopsis thaliana." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648263.

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Joardar, Archi. "GUIDE RNA-DEPENDENT AND INDEPENDENT tRNA MODIFICATIONS IN ARCHAEA." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/625.

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Stable RNAs undergo a wide variety of post-transcriptional modifications, that add to the functional repertoire of these molecules. Some of these modifications are catalyzed by stand-alone protein enzymes, while some others are catalyzed by RNA-protein complexes. tRNAs from all domains of life contain many such modifications, that increase their structural stability and refine their decoding properties. Certain regions of tRNAs are more frequently modified than others. Two such regions are the anticodon loop, and the TψC stem. In the halophilic euryarchaeon Haloferax volcanii, tRNATrp and tRNA
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Flower, Kirsty. "Methylation dependent interactions of viral transcription factor Zta with DNA." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/39322/.

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Epstein Barr Virus, a human herpes virus associated with infectious mononucleosis, Burkitt's lymphoma, Nasopharyngeal Carcinoma and Hodgkin's disease, can infect B cells and establish latency. Zta, a member of the bZIP transcription factor family, is a viral transcription and replication factor required for activation of lytic cycle. Zta is able to bind DNA, through specific Zta Response Elements (ZREs). Interestingly, Zta binds in a methylation dependent manner to specific CpGcontaining ZREs, known as Class III ZREs. RpZRE3 is one of the first examples of such a site, and can be found in the
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O'Hanlon, Karen Ann. "Studies on the enzyme DNA-dependent RNA polymerase." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266340.

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Varshney, Dhaval. "Regulation of RNA polymerase III transcription by DNA methylation and chromatin." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3114/.

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Mammalian genomes contain huge numbers of short interspersed elements (SINEs). An extreme case is provided by the human genome, which carries ~106 copies of Alu SINEs that together account for ~10% of total chromosomal DNA. SINEs spread by retrotransposition, which depends on their transcription by pol III. This transcription is heavily suppressed. Silencing is thought to involve DNA methylation and packaging the SINEs into chromatin structures that deny access of transcription factors. It has been argued that this may be of great importance to prevent SINEs from competing with essential genes
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Mondal, Tanmoy. "Epigenetic Regulation by Noncoding RNA." Doctoral thesis, Uppsala universitet, Genomik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160326.

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High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. Genomic imprinting is an epigenetic phenomenon whereby one of the parental alleles is silenced by epigenetic mechanism in a parent of origin-specific manner. A long ncRNA Kcnq1ot1 regulates imprinting of nearly 8 protein coding genes in the Kcnq1 imprinted cluster. Expression of Kcnq1ot1 is restricted
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Yim, Lok-hay Rita, and 嚴樂晞. "DNA methylation of tumour suppressive microRNA in mantle cell lymphoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/210192.

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Choudury, Sarah G. Choudury. "Identification and characterization of proteins required for RNA-directed DNA Methylation, including the RNA binding protein ALY1." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543508792612526.

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Books on the topic "RNA dependent DNA methylation"

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A, Clawson Gary, and Hoffmann-La Roche inc, eds. Nucleic acid methylation: Proceedings of a Hoffman-La Rouche-UCLA Colloquium on Nucleic Acid Methylation held at Frisco, Colorado, March 31-April 7, 1989. Wiley-Liss, 1990.

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Henri, Grosjean, ed. DNA and RNA modification enzymes: Structure, mechanism, function, and evolution. Landes Bioscience, 2009.

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Maher, Christopher J., and Elaine R. Mardis. Genomic Landscape of Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0004.

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The study of cancer genomics has advanced rapidly during the last decade due to the development of next generation or massively parallel technology for DNA sequencing. The resulting knowledge is transforming the understanding of both inherited (germline) genetic susceptibility and the somatic changes in tumor tissue that drive abnormal growth and progression. The somatic alterations in tumor tissue vary depending on the type of cancer and its characteristic “genomic landscape.” New technologies have increased the speed and lowered the cost of DNA sequencing and have enabled high-volume charact
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Dricu, Anica, ed. Methylation - From DNA, RNA and Histones to Diseases and Treatment. InTech, 2012. http://dx.doi.org/10.5772/2932.

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Grosjean, Henri. DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution. Taylor & Francis Group, 2009.

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Grosjean, Henri. DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution. Taylor & Francis Group, 2009.

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Methylation, Hoffmann-LA Roche-UCLA Colloquium on Nucleic Acid, Dawn B. Willis, Arthur Weissbach, and Gary A. Clawson. Nucleic Acid Methylation: Proceedings of a Hoffman-LA Roche-UCLA Colloquium on Nucleic Acid Methylation Held at Frisco, Colorado, March 31-April 7, (Ucla ... and Cellular Biology, New Ser., V. 128). Wiley-Liss, 1989.

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Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin B9 (folate) in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0012.

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Folate is a coenzyme in multiple biochemical pathways involving one-carbon metabolism, including amino acid metabolism, DNA and RNA synthesis, homocysteine metabolism, and methylation of DNA. The most overt consequence of folate deficiency is megaloblastic anaemia caused by the inhibition of DNA synthesis in red blood cell production. Folate deficiency may also influence the ability to maintain DNA methylation patterns in replicating cells, resulting in lasting phenotypic changes. Embryogenesis and fetal growth require higher levels of folate, which must be supplied maternally during pregnancy
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Schadt, Eric E. Network Methods for Elucidating the Complexity of Common Human Diseases. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0002.

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The life sciences are now a significant contributor to the ever expanding digital universe of data, and stand poised to lead in both the generation of big data and the realization of dramatic benefit from it. We can now score variations in DNA across whole genomes; RNA levels and alternative isoforms, metabolite levels, protein levels, and protein state information across the transcriptome, metabolome and proteome; methylation status across the methylome; and construct extensive protein–protein and protein–DNA interaction maps, all in a comprehensive fashion and at the scale of populations of
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Book chapters on the topic "RNA dependent DNA methylation"

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Paro, Renato, Ueli Grossniklaus, Raffaella Santoro, and Anton Wutz. "RNA-Based Mechanisms of Gene Silencing." In Introduction to Epigenetics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68670-3_6.

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AbstractAlthough epigenetic states are typically associated with DNA-methylation and posttranslational histone modifications, RNAs often play an important role in their regulation. Specific examples have already been discussed in the context of dosage compensation (see book ► Chap. 10.1007/978-3-030-68670-3_4 of Wutz) and genomic imprinting (see book ► Chap. 10.1007/978-3-030-68670-3_5 of Grossniklaus). In this Chapter, we will take a closer look at a particular class of RNAs implicated in gene silencing. Although the focus will lie on RNA-based silencing mechanisms in plants, many of its comp
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Wassenegger, Michael. "RNA-directed DNA methylation." In Plant Gene Silencing. Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4183-3_6.

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Kular, Lara, and Maja Jagodic. "DNA Methylation in Multiple Sclerosis." In RNA Technologies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14792-1_8.

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Mundorf, Annakarina, and Nadja Freund. "Early Life Stress and DNA Methylation." In RNA Technologies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14792-1_9.

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Jost, J. P., and H. P. Saluz. "Steroid hormone dependent changes in DNA methylation and its significance for the activation or silencing of specific genes." In DNA Methylation. Birkhäuser Basel, 1993. http://dx.doi.org/10.1007/978-3-0348-9118-9_19.

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Bruggeman, Emily C., and Bing Yao. "DNA Methylation in Neuronal Development and Disease." In RNA Technologies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14792-1_5.

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Monti, Paola, and Luca Ferrari. "The Exposome, DNA Methylation, and Neurodegenerative Disorders." In RNA Technologies. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-91072-2_3.

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Easwaran, Hariharan, and Stephen B. Baylin. "Origin and Mechanisms of DNA Methylation Dynamics in Cancers." In RNA Technologies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14792-1_2.

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Lucidi, Alessia, Daniela Tomaselli, Dante Rotili, and Antonello Mai. "DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation." In RNA Technologies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14792-1_12.

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Barra, Viviana, and Pietro Salvatore Carollo. "DNA Methylation Control over Aging: A Focus on Repetitive Elements." In RNA Technologies. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-91072-2_5.

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Conference papers on the topic "RNA dependent DNA methylation"

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He, Chuan. "Reversible DNA and RNA methylation in biological regulation." In XVIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414052.

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Kamalakaran, S., H. Giercksky Russnes, A. Janevski, et al. "Subtype Dependent Alterations of the DNA Methylation Landscape in Breast Cancer." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-1144.

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Panjarian, Shoghag B., Carolyn Slater, Jozef Madzo, Jaroslav Jelinek, Xiaowei Chen, and Jean-Pierre Issa. "Abstract 1071: Age-dependent DNA methylation in normal breast epithelium and breast cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1071.

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Wang, Xuting, Gary S. Pittman, Dan Su, et al. "Abstract 3647: Dose-dependent alteration of CpG methylation inAHRRandGFI1in mononuclear cell DNA of smokers." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3647.

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Martyushova, V. G., A. M. Timofeeva, and S. E. Sedykh. "METHYLATION-DEPENDENT RESTRICTION ENDONUCLEASES FOR THE ANALYSIS OF METHYLATION IN PROMOTER REGIONS OF GENES ASSOCIATED WITH THE PATHOGENESIS OF ALZHEIMER’S SYNDROME." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-255.

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DNA methylation plays an important role in epigenetic inheritance. Methylation of promoter regions of genes associated with the pathogenesis of Alzheimer’s disease has been shown to change during the development of the disease. In this work, a methylation-dependent restriction endonuclease and qPCR were used to analyse this process.
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Hong, Jin Hwa, Hyun Woong Cho, Jae Kwan Lee, Yikyeong Chun, and Jeong-An Gim. "Integrative analysis and machine learning application to TCGA DNA methylation, RNA-seq, and variant dataset in endometrial cancer." In KSGO 2023. Korean Society of Gynecologic Oncology, 2023. http://dx.doi.org/10.3802/jgo.2023.34.s1.fp_u01.

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Liu, Yu, Yang Liu, Zhengtao Xiao, and Xuerui Yang. "Abstract A2-54: DNA methylation-dependent transcription regulatory networks elucidate dynamics of transcription regulatory circuitry in cancers." In Abstracts: AACR Special Conference: Translation of the Cancer Genome; February 7-9, 2015; San Francisco, CA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.transcagen-a2-54.

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Liu, Yu, Yang Liu, Zhengtao Xiao, and Xuerui Yang. "Abstract B2-25: DNA methylation-dependent transcription regulatory networks elucidate dynamics of transcription regulatory circuitry in cancers." In Abstracts: AACR Special Conference: Computational and Systems Biology of Cancer; February 8-11, 2015; San Francisco, CA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.compsysbio-b2-25.

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Park, Jong-Lyul, Yong Sung Kim, Seon-Young Kim, et al. "Abstract 529: nc886, a noncoding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-529.

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Hong, Jin Hwa, Sohyeon Jeong, Hyun Woong Cho, Jae Kwan Lee, Yikyeong Chun, and Jeong-An Gim. "Integrative analysis of TCGA-OV DNA methylation, RNA-sequencing, and variants dataset using machine learning in predicting ovarian cancer survival rates." In The 39th Annual Meeting of the Korean Society of Gynecologic Oncology. Korean Society of Gynecologic Oncology, 2024. http://dx.doi.org/10.3802/jgo.2024.35.s2.p23.

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Reports on the topic "RNA dependent DNA methylation"

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Gal-On, Amit, Shou-Wei Ding, Victor P. Gaba, and Harry S. Paris. role of RNA-dependent RNA polymerase 1 in plant virus defense. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597919.bard.

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Objectives: Our BARD proposal on the impact of RNA-dependent RNA polymerase 1 (RDR1) in plant defense against viruses was divided into four original objectives. 1. To examine whether a high level of dsRNA expression can stimulate RDR1 transcription independent of salicylic acid (SA) concentration. 2. To determine whether the high or low level of RDR1 transcript accumulation observed in virus resistant and susceptible cultivars is associated with viral resistance and susceptibility. 3. To define the biogenesis and function of RDR1-dependent endogenous siRNAs. 4. To understand why Cucumber mosai
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Laurence, Jeffrey. Antibody to the RNA-Dependent DNA Polymerase of HTLV-III: Characterization and Clinical Associations. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada231466.

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Laurence, Jeffrey. Antibody to the RNA-Dependent DNA Polymerase of HTLV-III: characterization and Clinical Associations. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada227404.

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Laurence, Jeffrey. Antibody to the RNA-Dependent DNA Polymerase of HTLV-III: characterization and Clinical Associations. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada227519.

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Mawassi, Munir, and Valerian V. Dolja. Role of the viral AlkB homologs in RNA repair. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594396.bard.

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AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB functions in the viral infection cycle using a range of complementary genetic and biochemical approaches. Our hypotheses was that AlkB is required for efficient replication and genetic stability of viral RNA genomes The major objectives of the r
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Ostersetzer-Biran, Oren, and Jeffrey Mower. Novel strategies to induce male sterility and restore fertility in Brassicaceae crops. United States Department of Agriculture, 2016. http://dx.doi.org/10.32747/2016.7604267.bard.

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Abstract:
Abstract Mitochondria are the site of respiration and numerous other metabolic processes required for plant growth and development. Increased demands for metabolic energy are observed during different stages in the plants life cycle, but are particularly ample during germination and reproductive organ development. These activities are dependent upon the tight regulation of the expression and accumulation of various organellar proteins. Plant mitochondria contain their own genomes (mtDNA), which encode for rRNAs, tRNAs and some mitochondrial proteins. Although all mitochondria have probably evo
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