Relevant bibliographies by topics / Rottlerin

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Academic literature on the topic 'Rottlerin'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Rottlerin"

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Lee, Bogyeong, Jeongho Jeong, Hyun Kyung Kim, et al. "Rottlerin Promotes Beigeing and Non-Shivering Thermogenesis via LRP6 Inhibition." Food Engineering Progress 28, no. 2 (2024): 93–102. http://dx.doi.org/10.13050/foodengprog.2024.28.2.93.

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Obesity, characterized by excessive fat accumulation, poses global health risks, including metabolic disorders like type 2 diabetes and cardiovascular diseases, with its prevalence steadily rising. This study proposes that rottlerin induces anti-obesity effects by enhancing non-shivering thermogenesis in beige adipocytes D16 via LRP6 inhibition. As a result, treatment of D16 cells with rottlerin up to 5 μM showed no cytotoxicity. Rottlerin significantly increased the expression of proteins involved in substrate oxidation, such as UCP1 and PGC1α, while decreasing the expression of C/EBPβ associ
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Chen, Xu‐Ling, Yu Dong, and Ji‐Yu Wang. "The Practical Total Synthesis of Rottlerin and Rottlerone." ChemistrySelect 5, no. 29 (2020): 9206–9. http://dx.doi.org/10.1002/slct.202002245.

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Kim, Hyun Kyung, Eun Young Kang, and Gwang-woong Go. "Rottlerin, a Polyphenolic Compound, Alleviate Body Adiposity by Enhancing Lipolysis and Thermogenesis in Diet-Induced Obesity Mice." Current Developments in Nutrition 5, Supplement_2 (2021): 1222. http://dx.doi.org/10.1093/cdn/nzab055_032.

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Abstract Objectives Rottlerin (mallotoxin) is a polyphenolic compound in Mallotus philippensis. The anti-tumor, anti-inflammation, and mitochondrial uncoupling regulation effects of rottlerin have been known. However, the anti-obesity effect was not reported yet. Thus, we hypothesized that rottlerin would suppress body fat accumulation in obesity-induced mice. Methods Five-week-old male C57BL/6 mice were fed a high-fat diet (HFD) (60% kcal from fat) ad libitum for 8 weeks. Mice were randomly assigned to five groups as follows: 1) normal diet (18% kcal from fat), 2) negative control (60% kcal f
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Shivshankar, Pooja, Lei Lei, Jie Wang, and Guangming Zhong. "Rottlerin Inhibits Chlamydial Intracellular Growth and Blocks Chlamydial Acquisition of Sphingolipids from Host Cells." Applied and Environmental Microbiology 74, no. 4 (2007): 1243–49. http://dx.doi.org/10.1128/aem.02151-07.

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ABSTRACT We report that rottlerin, a plant-derived compound known to inhibit various mammalian kinases, profoundly inhibited chlamydial growth in cell culture with a minimal inhibition concentration of 1 μM. The inhibition was effective even when rottlerin was added as late as the middle stage of chlamydial infection cycle, against multiple Chlamydia species, and in different host cell lines. Pretreatment of host cells with rottlerin prior to infection also blocked chlamydial growth, suggesting that rottlerin targets host factors. Moreover, rottlerin did not alter the chlamydial infection rate
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Kim, Ye Jin, and Gwang-woong !Go. "Rottlerin Suppresses Fat Accumulation by Inhibiting Adipogenesis and De Novo Lipogenesis in 3T3-L1 Adipocytes." Current Developments in Nutrition 5, Supplement_2 (2021): 1224. http://dx.doi.org/10.1093/cdn/nzab055_034.

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Abstract Objectives Rottlerin is isolated from Mallotus japonicus, a rich-in polyphenol. Rottlerin is a PKC delta inhibitor known for an uncoupler of oxidative phosphorylation and anti-neoplastic agent. However, the effect of anti-obesity is not conclusive. This study hypothesized that rottlerin inhibits lipid accumulation in adipocytes. Methods 3T3-L1 cells were maintained with DMEM containing 10% BCS and 1% penicillin. The cells were seeded in a 6-well plate with a density of 8 × 104 followed by cultured for 4 days until reaching 120% confluency and incubated in a differentiation medium for
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Ohno, Izumi, Guido Eibl, Irina Odinokova, et al. "Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family." American Journal of Physiology-Gastrointestinal and Liver Physiology 298, no. 1 (2010): G63—G73. http://dx.doi.org/10.1152/ajpgi.00257.2009.

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Rottlerin is a polyphenolic compound derived from Mallotus philipinensis . In the present study, we show that rottlerin decreased tumor size and stimulated apoptosis in an orthotopic model of pancreatic cancer with no effect on normal tissues in vivo. Rottlerin also induced apoptosis in pancreatic cancer (PaCa) cell lines by interacting with mitochondria and stimulating cytochrome c release. Immunoprecipitation results indicated that rottlerin disrupts complexes of prosurvival Bcl-xL with Bim and Puma. Furthermore, siRNA knockdown showed that Bim and Puma are necessary for rottlerin to stimula
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Kim, Younhee, Jeongho Jeong, Sumin Kang та ін. "Rottlerin Inhibits Lipid Accumulation in Differentiated 3T3-L1 Cells through LRP6/β-Catenin/TCF7L2 Down-Regulation". Food Engineering Progress 28, № 3 (2024): 225–33. http://dx.doi.org/10.13050/foodengprog.2024.28.3.225.

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Obesity, a global health concern characterized by excessive fat accumulation, necessitates the discovery of anti-obesity compounds. Rottlerin, known for its anti-cancer effects as a mitochondrial uncoupler, has been a subject of interest. However, its impact on reducing intracellular lipid accumulation remains a gap in our understanding. This study aimed to fill this gap by dissecting the mechanism of rottlerin in 3T3-L1 adipocytes. We treated differentiated 3T3-L1 cells with 0-20 μM of rottlerin for 48 hours to assess its capability to induce lipid accumulation. Notably, we observed no cytoto
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Maioli, Emanuela, Lucedio Greci, Karel Soucek та ін. "Rottlerin Inhibits ROS Formation and Prevents NFκB Activation in MCF-7 and HT-29 Cells". Journal of Biomedicine and Biotechnology 2009 (2009): 1–7. http://dx.doi.org/10.1155/2009/742936.

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Rottlerin, a polyphenol isolated from Mallotus Philippinensis, has been recently used as a selective inhibitor of PKCδ, although it can inhibit many kinases and has several biological effects. Among them, we recently found that Rottlerin inhibits the Nuclear FactorκB (NFκB), activated by either phorbol esters orH2O2. Because of the redox sensitivity of NFκB and on the basis of Rottlerin antioxidant property, we hypothesized that Rottlerin could prevent NFκB activation acting as a free radicals scavenger, as other natural polyphenols. The current study confirms the antioxidant property of Rottl
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Molina, Yessenia L., David García-Seisdedos, Bohdan Babiy, et al. "Rottlerin Stimulates Exosome/Microvesicle Release Via the Increase of Ceramide Levels Mediated by Ampk in an In Vitro Model of Intracellular Lipid Accumulation." Biomedicines 10, no. 6 (2022): 1316. http://dx.doi.org/10.3390/biomedicines10061316.

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Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle secretion in a model of intracellular lipid trafficking impairment, and elucidated the mechanism of action. In a model of lipid trafficking impairment in C6 glia cells, rottlerin increased ceramide levels, while decreasing hexosylceramide content. This was accompanied by increased exosome/microvesicle secretion, thereby reducing the concentration of lipids in the endo
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Kang, Yeonglim, Jong-Chul Choi, Joong-Bok Lee, Seung-Yong Park та Changin Oh. "Rottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway". PLOS One 20, № 5 (2025): e0324500. https://doi.org/10.1371/journal.pone.0324500.

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Rottlerin exerts antiviral activity against various enveloped viruses, yet the mechanism by which it inhibits viral replication and the associated signaling pathways remains unclear. Here, we investigated the mechanisms for the antiviral effects of rottlerin against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in vitro. We demonstrate that PRRSV enters host cells via macropinocytosis. Rottlerin, a PKCδ inhibitor, partially inhibits PRRSV entry by decreasing actin polymerization, as evidenced by alterations in actin dynamics. LIM domain kinase 1 (LIMK1) is essential for PRRSV rep
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Dissertations / Theses on the topic "Rottlerin"

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Lama, Zoé. "Étude fonctionnelle d'inhibiteurs de kinases réprimant la réplication du virus de la rage." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS490.

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Alors que les étapes du cycle du virus de la rage sont plutôt bien décrites, les interactions du virus avec la machinerie cellulaire restent mal connues. Le but de ce projet de thèse a été d’identifier et caractériser les voies de signalisation cellulaires impliquées dans le déroulement du cycle viral. Les kinases cellulaires jouent un rôle majeur dans la régulation de ces voies et certaines protéines rabiques ont déjà été décrites comme cibles de ces enzymes. Afin d’identifier les kinases impliquées dans le déroulement du cycle viral, nous avons réalisé un criblage d’une banque d’inhibiteur d
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Sivanathan, Sivatharushan [Verfasser]. "Synthese enantiomerenreiner α-Hydroxycarbonsäuren, neuer Cyclooctadepsipeptide sowie Studien zur Totalsynthese von Rottlerin / Sivatharushan Sivanathan". Wuppertal : Universitätsbibliothek Wuppertal, 2015. http://d-nb.info/1076930166/34.

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Heineck, Lukas [Verfasser], and Christian [Akademischer Betreuer] Kurts. "Der Einfluss von Rottlerin auf T-Zellpräsentation und -aktivierung / Lukas Heineck ; Betreuer: Christian Kurts." Marburg : Philipps-Universität Marburg, 2019. http://d-nb.info/1199537519/34.

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Juneja, Manisha. "Novel insights into MACC1 transcriptional regulation for identifying small molecule MACC1 inhibitors to restrict colorectal cancer progression." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/17038.

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MACC1 wurde als prognostischer Biomarker für die Tumorprogression und das Metastasen-freie Überleben im KRK sowie in anderen soliden Tumoren beschrieben. Das Gen induziert Zellmotilität und Proliferation in Zellkultur sowie die Metastasierung im Mausmodell. Damit stellt MACC1 ein vielversprechendes Ziel für die Intervention bei Tumorprogression und –metastasierung und damit für die Behandlung von KRK-Patienten dar. Unser Ziel war es, die Transkription von MACC1 zu inhibieren. Hierfür identifizierten wir zunächst die Promoter-Region von MACC1 und untersuchten MACC1s transkriptionelles Regulati
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Cordeiro, Thuany de Moura. "Efeitos da rottlerin na esquizogonia eritrocitária de Plasmodium falciparum e implementação e avaliação de teste in vitro por fluorescência de atividade antiplasmodial." reponame:Repositório Institucional da UnB, 2014. http://repositorio.unb.br/handle/10482/15666.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2014.<br>Submitted by Alaíde Gonçalves dos Santos (alaide@unb.br) on 2014-04-29T12:50:20Z No. of bitstreams: 1 2014_ThuanydeMouraCordeiro.pdf: 3960809 bytes, checksum: 4b394c3182d7b2be77db6f48e1225c6d (MD5)<br>Approved for entry into archive by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br) on 2014-05-23T12:40:35Z (GMT) No. of bitstreams: 1 2014_ThuanydeMouraCordeiro.pdf: 3960809 bytes, checksum: 4b394c3182d7b2be77db6f48e1225c6d (MD5)<br>Made available in DSpace on 2
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Nguyen, Khoa Thuy Diem. "Energy metabolism in the brain and rapid distribution of glutamate transporter GLAST in astrocytes." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3996.

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Glutamate transporters play a role in removing extracellular excitatory neurotransmitter, L-glutamate into the cells. The rate of the uptake depends on the density of the transporters at the membrane. Some studies claimed that glutamate transporters could transit between the cytoplasm and the membrane on a time-scale of minutes. The present study examined the distribution of glutamate transporter GLAST predominantly expressed in rat cortical cultured astrocytes between the membrane and the cytoplasm by using deconvolution microscopy and then analyzing the images. The regulation of the dist
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Nguyen, Khoa Thuy Diem. "Energy metabolism in the brain and rapid distribution of glutamate transporter GLAST in astrocytes." University of Sydney, 2008. http://hdl.handle.net/2123/3996.

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Doctor of Philosophy (Medicine)<br>Glutamate transporters play a role in removing extracellular excitatory neurotransmitter, L-glutamate into the cells. The rate of the uptake depends on the density of the transporters at the membrane. Some studies claimed that glutamate transporters could transit between the cytoplasm and the membrane on a time-scale of minutes. The present study examined the distribution of glutamate transporter GLAST predominantly expressed in rat cortical cultured astrocytes between the membrane and the cytoplasm by using deconvolution microscopy and then analyzing the
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Contreras, Xavier. "Rôle des voies PKC et calcium dans les productions de TNF-alpha et d'IL-10 induites par la protéine Tat du Virus de l'immuodéficience humaine chez le monocyte humain et dans la réplication de virus R5-tropiques dans le macrophage." Toulouse 3, 2005. http://www.theses.fr/2005TOU30012.

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Les objectifs de cette thèse sont d’une part la caractérisation des voies de signalisation impliquées dans la production de TNF-a et d’IL-10 par les monocytes/macrophages humains stimulés par la protéine Tat du VIH-1 et d’autre part l’évaluation du rôle de ces voies de signalisation dans la réplication virale. Ainsi, la protéine Tat active la voie calcique et la voie de la PKC dans le monocyte/macrophage pour stimuler la production du TNF-a et de l’IL-10 via son domaine N-terminal 1-45. Le domaine 20-45 stimule l’entrée du calcium dans le monocyte via les canaux calciques DHP sensibles. Tat in
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Koterba, Kristen L. "Regulation of Autophagy and Cell Death in Breast Carcinoma Cells." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1276005638.

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Rottler, Andreas [Verfasser]. "Investigation of Radial Metamaterials / Andreas Rottler." München : Verlag Dr. Hut, 2013. http://d-nb.info/1037286847/34.

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Books on the topic "Rottlerin"

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Misaca, Constantin. How I escaped from Communist Romania, or... the Story of My Rottlen Life. Lulu Press, Inc., 2010.

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Book chapters on the topic "Rottlerin"

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Bhandari, Khadka B., Suresh Subedi, Ripu M. Kunwar, Rainer W. Bussmann, and Narel Y. Paniagua-Zambrana. "Grewia disperma Rottler ex Spreng. Malvaceae." In Ethnobotany of the Himalayas. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45597-2_112-1.

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Bhandari, Khadka B., Suresh Subedi, Ripu M. Kunwar, Rainer W. Bussmann, and Narel Y. Paniagua-Zambrana. "Grewia disperma Rottler ex Spreng. Malvaceae." In Ethnobotany of the Himalayas. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57408-6_112.

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"ROTTLERA." In Directory Of Plants Containing Secondary Metabolites. CRC Press, 1991. http://dx.doi.org/10.1201/b12561-426.

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Y R, Nagesh, Karthik T D, Dr Sumanth B, Dr Riaz Mahmood, and Dr V. Krishna. "UNVEILING NATURE'S GIFT TO EXTEND FOOD SHELF LIFE BY USING PLANT-BASED ANTIOXIDANTS, FROM CHROZOPHORA ROTTLERI." In Futuristic Trends in Agriculture Engineering & Food Sciences Volume 3 Book 18. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bcag18p2ch2.

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Chrozophora Rottleri, also known as Suryavarti, is a Euphorbiaceae family medicinal herb. This plant can be found in a variety of environments, including Central Java, India, Myanmar, Thailand, and the Andaman Islands. Tribes and traditional healers use it for a variety of therapeutic purposes. It contains alkaloids, sugars, glycosides, tannins, steroids, flavonoids, and saponins, as well as phytochemicals with, antibacterial, antioxidant, anti-inflammatory, anti-helminthic as well as antimutagenic functions. Amid worries about this safety regarding synthetic antioxidants, Chrozophora rottleri
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"Kachri (Cucumis callosus [Rottler] Cogn.)." In Handbook of Cucurbits. CRC Press, 2016. http://dx.doi.org/10.1201/b19233-48.

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Conference papers on the topic "Rottlerin"

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Goldklang, Monica P., Nazish Sayed, Takwi Nkyimbeng, et al. "Rottlerin Suppresses Airway Hyperreactivity And Inflammation In Mouse Models Of Experimental Asthma." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3580.

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Su, Hsin-Yuan, Richard Waldron, Raymond Gong, Stephen Pandol, and Aurelia Lugea. "Abstract 1769: Rottlerin induces ER stress-mediated cell death in pancreatic stellate cells." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1769.

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Joeckel, Matthias W., Elke Schneider, Frederik C. Roos, Christian Hampel, Joachim W. Thueroff, and Walburgis Brenner. "Abstract 1041: Sorafenib in combination with rottlerin show an additive effects in renal cell carcinoma (RCC) cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1041.

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Kumar, Dhruv. "Abstract 329: Rottlerin induced autophagy by targeting multiple sites that leads to the apoptosis in cancer stem cells." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-329.

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Prudnikova, Tatiana, and Jonathan Chernoff. "Abstract LB-011: PAK1 inhibitor FRAX1036 sensitizes ovarian cancer cells with amplified 11q13 to cytotoxic effect of rottlerin." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-lb-011.

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Ashour, Ahmed A., Abdel-Aziz H. Abdel-Aziz, Ahmed M. Mansour, Sultan N. Alpay, Kevin Dalby, and Bulent Ozpolat. "Abstract 848: Inhibition of eukaryotic elongation factor-2 kinase mediates Rottlerin induced effects in apoptosis and cell proliferation inhibition in human pancreatic cancer cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-848.

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