Academic literature on the topic 'Salvinorin A'

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Journal articles on the topic "Salvinorin A"

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Su, Diansan, John Riley, Willis J. Kiessling, William M. Armstead та Renyu Liu. "Salvinorin A Produces Cerebrovasodilation through Activation of Nitric Oxide Synthase, κ Receptor, and Adenosine Triphosphate–sensitive Potassium Channel". Anesthesiology 114, № 2 (1 лютого 2011): 374–79. http://dx.doi.org/10.1097/aln.0b013e318204e029.

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Background Salvinorin A is a nonopioid, selective κ opioid-receptor agonist. Despite its high potential for clinical application, its pharmacologic profile is not well known. In the current study, we hypothesized that salvinorin A dilates pial arteries via activation of nitric oxide synthase, adenosine triphosphate-sensitive potassium channels, and opioid receptors. Methods Cerebral artery diameters and cyclic guanosine monophosphate in cortical periarachnoid cerebrospinal fluid were monitored in piglets equipped with closed cranial windows. Observation took place before and after salvinorin A
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Braida, Daniela, Andrea Donzelli, Roberta Martucci, Valeria Capurro, and Mariaelvina Sala. "Learning and Memory Impairment Induced by Salvinorin A, the Principal Ingredient of Salvia divinorum, in Wistar Rats." International Journal of Toxicology 30, no. 6 (September 29, 2011): 650–61. http://dx.doi.org/10.1177/1091581811418538.

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The effects of salvinorin A ( Salvia divinorum principal ingredient), a potent κ-opioid natural hallucinogen, on learning and memory were investigated. Wistar rats were tested in the 8-arm radial maze, for object recognition and passive avoidance tasks for spatial, episodic, and aversive memory. Attention was assessed using a latent inhibition task. Salvinorin A (80-640 μg/kg subcutaneous [sc]) did not affect short-term memory, but it impaired spatial long-term memory. Episodic and aversive memories were impaired by salvinorin A (160-640 μg/kg). Memory impairment was blocked by the selective κ
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Brito-da-Costa, Andreia Machado, Diana Dias-da-Silva, Nelson G. M. Gomes, Ricardo Jorge Dinis-Oliveira, and Áurea Madureira-Carvalho. "Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects." Pharmaceuticals 14, no. 2 (February 3, 2021): 116. http://dx.doi.org/10.3390/ph14020116.

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Salvia divinorum Epling and Játiva is a perennial mint from the Lamiaceae family, endemic to Mexico, predominantly from the state of Oaxaca. Due to its psychoactive properties, S. divinorum had been used for centuries by Mazatecans for divinatory, religious, and medicinal purposes. In recent years, its use for recreational purposes, especially among adolescents and young adults, has progressively increased. The main bioactive compound underlying the hallucinogenic effects, salvinorin A, is a non-nitrogenous diterpenoid with high affinity and selectivity for the κ-opioid receptor. The aim of th
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Socała, Katarzyna, Urszula Doboszewska, and Piotr Wlaź. "Salvinorin A Does Not Affect Seizure Threshold in Mice." Molecules 25, no. 5 (March 7, 2020): 1204. http://dx.doi.org/10.3390/molecules25051204.

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The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including epilepsy. Salvinorin A is a potent plant-derived hallucinogen that acts as a highly selective κ-opioid receptor agonist. It has unique structure and pharmacological properties, but its influence on seizure susceptibility has not been studied so far. Therefore, the aim of the present study was to investigate the effect of salvinorin A on seizure thresholds in three acute seizure tests in mice. We also examined its effect on muscular strength and
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Hill, Sarah J., Aurélien U. C. M. Brion, and Ryan A. Shenvi. "Chemical syntheses of the salvinorin chemotype of KOR agonist." Natural Product Reports 37, no. 11 (2020): 1478–96. http://dx.doi.org/10.1039/d0np00028k.

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Ostrozhenkova, E. G. "Biosynthesis of salvinorin A." IOP Conference Series: Earth and Environmental Science 613 (December 23, 2020): 012101. http://dx.doi.org/10.1088/1755-1315/613/1/012101.

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Munro, Thomas A., Douglas M. Ho, and Bruce M. Cohen. "Salvinorin B methoxymethyl ether." Acta Crystallographica Section E Structure Reports Online 68, no. 11 (October 27, 2012): o3225—o3226. http://dx.doi.org/10.1107/s1600536812043449.

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Hagiwara, Hisahiro, Takashi Nojima, Yuhki Suka, Takashi Hoshi, and Toshio Suzuki. "First Total Synthesis of the Neo-Clerodane Diterpenoid Salvinorin F." Natural Product Communications 6, no. 3 (March 2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600306.

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Line, Nathan J., Aaron C. Burns, Sean C. Butler, Jerry Casbohm, and Craig J. Forsyth. "Total Synthesis of (−)-Salvinorin A." Chemistry - A European Journal 22, no. 50 (November 4, 2016): 17983–86. http://dx.doi.org/10.1002/chem.201604853.

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Tsujikawa, Kenji, Kenji Kuwayama, Hajime Miyaguchi, Tatsuyuki Kanamori, Yuko T. Iwata, Takemi Yoshida, and Hiroyuki Inoue. "Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan." Forensic Science International 180, no. 2-3 (September 2008): 105–9. http://dx.doi.org/10.1016/j.forsciint.2008.07.008.

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Dissertations / Theses on the topic "Salvinorin A"

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LaBelle, Keri Lyn. "Development of presumptive macroscopic, microscopic, and colorimetric tests for Salvia divinorum, salvinorin A, and salvinorin B." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12463.

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Thesis (M.S.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Salvia divinorum (S. divinorum) is a psychoactive plant from the Lamiaceae (mint) family originating in the Oaxaca region of Mexico. The plant's psychoactive compound, salvinorin A (sal A) has been found to be u
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Lingham, Anthony, and arlingham@hotmail com. "Studies Toward the Synthesis of Salvinorin A." RMIT University. Applied Sciences, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080428.095126.

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Salvinorin A [(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naptho[2,1-c]pyran-7-carboxylic acid methyl ester] is a trans-neoclerodane diterpene from the leaves of the hallucinogenic Mexican sage Salvia divinorum and has been identified as the principal psychoactive component in this plant of traditional spiritual importance. Salvinorin A is the most potent naturally occurring hallucinogen found so far and is reported to act selectively as a ƒÛ-opioid receptor agonist. Synthetic modification of the natural product has contributed to a number
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McGovern, Donna. "Salvinorin A: Fragment Synthesis and Modeling Studies." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1862.

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Salvinorin A is a non-nitrogenous, selective kappa opioid receptor agonist with potent hallucinogenic properties. Because Salvinorin A has no basic nitrogen, it does not readily adhere to the “message-address” concept of selectivity for the opioid receptors. Therefore, a better understanding of how salvinorin A and its analogs interact with the kappa opioid receptor may shed some light on how salvinorin A obtains its potency and selectivity. The structure-affinity relationships (SAFIR) of salvinorin A and its analogs along with a discussion of the selectivity of the opioid receptors, is pre
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Butler, Sean Colin. "Construction of the Carbon Skeleton of Salvinorin A." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306524854.

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Casbohm, Jerry S. "Modifications to the Synthesis of the Salvinorin A Carbon Skeleton." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462816273.

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Line, Nathan. "Total Synthesis of Salvinorin A via an IMDA-Tsuji Allylation Strategy." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461161309.

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Yan, Feng. "Molecular mechanisms by which salvinorin A binds to and activates the k-opioid receptor." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1207342013.

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Kutrzeba, Lukasz. "Biosynthesis of Salvinorin A, : a potent hallucinogen from Salvia Divinorum Epling & Jativa /." Full text available from ProQuest UM Digital Dissertations, 2009. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1804960241&SrchMode=1&sid=12&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1269370294&clientId=22256.

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Yan, Feng. "Molecular Mechanisms by which Salvinorin A Binds to and Activates the κ-Opioid Receptor". Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1207342013.

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McGee, Philippe. "Application of Gold(I) Catalysis in the Synthesis of Bridged Carbocycles, (±)-Magellanine and (±)-Salvinorin A." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38485.

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Gold was considered for a long time to be an inert metal and was only in 1986 that the first homogeneous gold-catalyzed transformation was reported. In our laboratory, we isolated a surprisingly stable vinyl complex that resulted from an unexpected 1,2-silyl migration while working on a gold(I)-catalyzed reaction for the synthesis of polyprenylated polycyclic acylphloroglucinols (PPAPs). We herein report the isolation of a variety of organogold species where we could control the silyl migration based on the nature of the silyl group installed on the terminal alkyne. Silyl groups bearing an aro
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Books on the topic "Salvinorin A"

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Turner, D. M. Salvinorin: The psychedelic essence of Salvia divinorum. San Francisco, CA: Panther Press, 1996.

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Lawrence, Jonathan Farrel. I. Studies toward the total synthesis of eleutherobin: II. Total synthesis of salvinorin A. 2008.

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Book chapters on the topic "Salvinorin A"

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"Salvia divinorumEpling & Jativa and Salvinorin A." In Medical Toxicology of Drug Abuse, 961–67. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118105955.ch65.

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Tanaka, Hiroyuki, Madan Kumar Paudel, Osamu Shirota, Kaori Sasaki-Tabata, Setsuko Sekita, and Satoshi Morimoto. "Enzyme Immunoassay for Salvinorin A (a Main Component in Salvia divinorum )." In Neuropathology of Drug Addictions and Substance Misuse, 749–56. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-800212-4.00070-4.

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Butelman, Eduardo R., and Mary Jeanne Kreek. "The Widely Available Hallucinogenic Plant Salvia divinorum and Its Main Component, Salvinorin A." In Neuropathology of Drug Addictions and Substance Misuse, 739–46. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-800212-4.00069-8.

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"Salvinorin A: Example of a Non-Alkaloidal Bioactive Opioid from a Plant Source." In Kratom and Other Mitragynines, 56–73. CRC Press, 2014. http://dx.doi.org/10.1201/b17666-8.

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"8-Epi-Salvinorin B: Crystal Structure and Affinity at the K Opioid Receptor." In Organic Chemistry, 264–70. Apple Academic Press, 2011. http://dx.doi.org/10.1201/b12874-28.

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Kivell, Bronwyn M., Amy W. M. Ewald, and Thomas E. Prisinzano. "Salvinorin A Analogs and Other Kappa-Opioid Receptor Compounds as Treatments for Cocaine Abuse." In Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse, 481–511. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-420118-7.00012-3.

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