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Journal articles on the topic 'SCD1'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Levitsky, A., A. Gozhenko, V. Velichko, and I. Selivanskaya. "The effect of dietary fat supplements on the activity of palmitic and stearic acid desaturases based on the results of a study of the fatty acid composition of neutral lipids in blood serum and liver of rats receiving a fat-free diet." Journal of Education, Health and Sport 12, no. 1 (2022): 197–206. http://dx.doi.org/10.12775/jehs.2022.12.01.016.

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Background. Desaturase enzymes are involved in the formation of monoenoic acids from saturated fatty acids. One such enzyme is stearyl-CoA-desaturase (SCD1), which converts stearic acid to oleic acid. The aim of this work was to determine the effect of edible fats with different fatty acid compositions on SCD1 activity. Methods. High linoleic sunflower oil (HLSO), high oleic sunflower oil (HOSO) and palm oil (PO) were used. The rats were fed for 30 days with a semi-synthetic diet that did not contain any fats (FFD) and fat diets containing 5 % of each of the above oils. In animals, lipid

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Li, Ying-chun, Chang-rung Chen, and Eric C. Chang. "Fission Yeast Ras1 Effector Scd1 Interacts With the Spindle and Affects Its Proper Formation." Genetics 156, no. 3 (2000): 995–1004. http://dx.doi.org/10.1093/genetics/156.3.995.

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Abstract Ras1 GTPase is the Schizosaccharomyces pombe homolog of the mammalian Ha-Ras proto-oncoprotein. Ras1 interacts with Scd1 (aka Ral1), a presumptive guanine nucleotide exchange factor for Cdc42sp, to control organization of the cytoskeleton. In this study, we demonstrated that the scd1 deletion (scd1Δ) induced hypersensitivity to microtubule destabilizing drugs and instability of the minichromosome. Overexpression of scd1 induced formation of abnormal spindles and chromosome missegregation. The scd1 deletion worsened the defects of spindle formation in tubulin mutants; by contrast, it d

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Li, Yingchun, and Eric C. Chang. "Schizosaccharomyces pombeRas1 Effector, Scd1, Interacts With Klp5 and Klp6 Kinesins to Mediate Cytokinesis." Genetics 165, no. 2 (2003): 477–88. http://dx.doi.org/10.1093/genetics/165.2.477.

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AbstractFission yeast Scd1 is an exchange factor for Cdc42 and an effector of Ras1. In a screen for scd1 interacting genes, we isolated klp5 and klp6, which encode presumptive kinesins. Klp5 and Klp6 form a complex to control the same processes, which so far include microtubule dynamics and chromosome segregation. We showed that klp5 or klp6 inactivation in combination with the scd1 deletion (scd1Δ) created a synthetic temperature-dependent growth defect. Further genetic analysis demonstrated that Klp5 and Klp6 interacted specifically with the Ras1-Scd1 pathway, but not with the Ras1-Byr2 path

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Mnatsakanyan, Hayk, Caline Pechdimaljian, Roshani Jha, et al. "CSIG-17. SCD5 PROTECTS GLIOBLASTOMA STEM CELLS FROM DEATH AND DIFFERENTIATION BY MODULATING INTRACELLULAR LIPID COMPOSITION." Neuro-Oncology 24, Supplement_7 (2022): vii42. http://dx.doi.org/10.1093/neuonc/noac209.166.

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Abstract Glioblastoma (GBM) is the most common malignant brain cancer in adults, enriched in a small subpopulation of glioma stem cells (GSC), which can drive tumor recurrence and therapeutic resistance. Considerable evidence suggests that the endogenous levels of unsaturated fatty acids (FA) are crucial regulators of GSCs survival and self-renewal. Stearoyl-CoA desaturase-1 (SCD-1) is the most abundant desaturase in humans. We have previously shown that SCD1 activity is required for GSCs self-renewal and brain tumor initiation. However, SCD1 orthologous isoform, SCD5, has been poorly characte

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Chu, Kiki, Makoto Miyazaki, Weng Chi Man, and James M. Ntambi. "Stearoyl-Coenzyme A Desaturase 1 Deficiency Protects against Hypertriglyceridemia and Increases Plasma High-Density Lipoprotein Cholesterol Induced by Liver X Receptor Activation." Molecular and Cellular Biology 26, no. 18 (2006): 6786–98. http://dx.doi.org/10.1128/mcb.00077-06.

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ABSTRACT Stearoyl-coenzyme A desaturase (SCD) is the rate-limiting enzyme necessary for the biosynthesis of monounsaturated fatty acids. In this study, we investigated the regulation of mouse SCD1 by liver X receptor (LXR) and its role in plasma lipoprotein metabolism upon LXR activation. In vivo, the SCD1 gene remained induced upon LXR activation in the absence of sterol regulatory element-binding protein 1c (SREBP-1c), a known transcriptional regulator of SCD1. Serial deletion and point mutation analyses in reporter gene assays, as well as a gel mobility shift assay, identified an LXR respon

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Wei, Bin, Brian S. Hercyk, Nicholas Mattson, et al. "Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis." Molecular Biology of the Cell 27, no. 8 (2016): 1235–45. http://dx.doi.org/10.1091/mbc.e15-10-0700.

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The Rho-family GTPase Cdc42 regulates cell polarity and localizes to the cell division site. Cdc42 is activated by guanine nucleotide exchange factors (GEFs). We report that Cdc42 promotes cytokinesis via a unique spatiotemporal activation pattern due to the distinct action of its GEFs, Gef1 and Scd1, in fission yeast. Before cytokinetic ring constriction, Cdc42 activation, is Gef1 dependent, and after ring constriction, it is Scd1 dependent. Gef1 localizes to the actomyosin ring immediately after ring assembly and promotes timely onset of ring constriction. Gef1 is required for proper actin o

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Lamas, Iker, Nathalie Weber, and Sophie G. Martin. "Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast." Cells 9, no. 9 (2020): 2089. http://dx.doi.org/10.3390/cells9092089.

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The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 promotes polarized growth at cell poles, while inactive Cdc42-GDP localizes ubiquitously also along cell sides. Zones of Cdc42 activity are maintained by positive feedback amplification involving the formation of a complex between Cdc42-GTP, the scaffold Scd2, and the guanine nucleotide exchange factor (GEF) Scd1, which promotes the activation of more Cdc42. Here, we use the CRY2-CIB1 optogenetic system to recruit and cluster a cytoso

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Mnatsakanyan, Hayk, Elie Roumieh, Caline Pechdimaljian, Joelle El Hokayem, Alessandro Sammarco, and Christian Badr. "DNAR-12. STEAROYL-COA DESATURASE REGULATES DNA DAMAGE REPAIR IN GBM BY MODULATING PARP1 ACTIVITY." Neuro-Oncology 26, Supplement_8 (2024): viii119—viii120. http://dx.doi.org/10.1093/neuonc/noae165.0463.

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Abstract Glioblastoma (GBM) is the most prevalent malignant brain cancer in adults, notorious for its aggressiveness and resistance to therapy. GBM patients commonly receive radiation therapy combined with temozolomide (TMZ), which engages tumor cells to promote lethal DNA damage and subsequent cytotoxicity. Active DNA repair mechanisms, particularly in a subset population of GBM stem-like cells (GSCs), drive therapeutic resistance, thus largely contributing to the bleak prognosis of GBM. Poly (ADP-ribose) polymerases (PARPs) are essential in various cellular processes, including DNA repair. W

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Kelly, Felice D., and Paul Nurse. "Spatial control of Cdc42 activation determines cell width in fission yeast." Molecular Biology of the Cell 22, no. 20 (2011): 3801–11. http://dx.doi.org/10.1091/mbc.e11-01-0057.

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The fission yeast Schizosaccharomyces pombe is a rod-shaped cell that grows by linear extension at the cell tips, with a nearly constant width throughout the cell cycle. This simple geometry makes it an ideal system for studying the control of cellular dimensions. In this study, we carried out a near-genome-wide screen for mutants wider than wild-type cells. We found 11 deletion mutants that were wider; seven of the deleted genes are implicated in the control of the small GTPase Cdc42, including the Cdc42 guanine nucleotide exchange factor (GEF) Scd1 and the Cdc42 GTPase-activating protein (GA

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Papadaki, Piyi, Véronique Pizon, Brian Onken, and Eric C. Chang. "Two Ras Pathways in Fission Yeast Are Differentially Regulated by Two Ras Guanine Nucleotide Exchange Factors." Molecular and Cellular Biology 22, no. 13 (2002): 4598–606. http://dx.doi.org/10.1128/mcb.22.13.4598-4606.2002.

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ABSTRACT How a given Ras prreotein coordinates multiple signaling inputs and outputs is a fundamental issue of signaling specificity. Schizosaccharomyces pombe contains one Ras, Ras1, that has two distinct outputs. Ras1 activates Scd1, a presumptive guanine nucleotide exchange factor (GEF) for Cdc42, to control morphogenesis and chromosome segregation, and Byr2, a component of a mitogen-activated protein kinase cascade, to control mating. So far there is only one established Ras1 GEF, Ste6. Paradoxically, ste6 null (ste6Δ) mutants are sterile but normal in cell morphology. This suggests that S

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Hirota, Kouji, Kayoko Tanaka, Kunihiro Ohta, and Masayuki Yamamoto. "Gef1p and Scd1p, the Two GDP-GTP Exchange Factors for Cdc42p, Form a Ring Structure that Shrinks during Cytokinesis inSchizosaccharomyces pombe." Molecular Biology of the Cell 14, no. 9 (2003): 3617–27. http://dx.doi.org/10.1091/mbc.e02-10-0665.

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Fission yeast Cdc42p, a small GTPase of the Rho family, is essential for cell proliferation and maintenance of the rod-like cell morphology. Scd1/Ral1p is a GDP-GTP exchange factor (GEF) for Cdc42p. This study and a parallel study by others establish that Gef1p is another GEF for Cdc42p. Deletions of gef1 and scd1 are synthetically lethal, generating round dead cells, and hence mimic the phenotype of cdc42 deletion. Gef1p is localized mainly to the cell division site. Scd1p is also there, but it is also detectable in other parts of the cell, including the nucleus, growing ends, and the tips of

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Zhang, Lumin, Tomohiro Yamasaki, Tyrone Dowdy, Adrian Lita, Mark Gilbert, and Mioara Larion. "CSIG-40. STEAROYL-COA DESATURASE 1 (SCD1) IS REQUIRED FOR WNT SIGNALING TO INDUCE AN APOPTOSIS IN IDH MUTANT GLIOMA." Neuro-Oncology 24, Supplement_7 (2022): vii47—vii48. http://dx.doi.org/10.1093/neuonc/noac209.189.

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Abstract BACKGROUND AND HYPOTHESES SCD1, a major enzyme of saturated fatty acids, has been implicated to be important for tumor metabolic reprograming. Our previous study show that a high level of SCD1 mRNA is associated with IDH1mut lower grade gliomas. IDH1mut glioma cells are more sensitive to SFA induced apoptosis. However, the underlying mechanism remains unclear. In this study, we investigate the functions of SCD1 in IDHmut glioma and the potential contribution of SCD1 for cancer therapy of glioma. STUDY DESIGN AND METHODS The genetically engineered IDH wild-type, IDHmut and patient deri

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Yadav, Sarita Ramsaran, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, and Nilanjana Das. "DEGRADATION OF AZO DYE AND ELECTRICITY GENERATION USING YEAST MEDIATED MICROBIAL FUEL CELL." Fungal Territory 1, no. 1 (2018): 1–4. http://dx.doi.org/10.36547/ft.2018.1.1.1-4.

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In the present study, the efficiency of yeast mediated microbial fuel cell (MFC) was investigated towards degradation of Trypan blue (azo dye) and electricity generation. Five yeast strains viz. SC1, SC2, SCD1, SCD2, and SCD3 were isolated from different sources. The internal resistance of yeast isolates was tested using ferric oxide reduction method. To maximize the power density of MFC, NaCl was added to the medium and NaCl tolerance of yeast strains was tested. Among the five isolates, SC1 and SCD2 showed maximum ferric oxide reduction and NaCl tolerance. Initially, 5 % of SC1 and SCD2 yeas

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Park, David, and Christian Badr. "DDRE-05. STEAROYL COA DESATURASE IS ESSENTIAL FOR REGULATION OF ENDOPLASMIC RETICULUM HOMEOSTASIS AND TUMOR GROWTH IN GLIOBLASTOMA CANCER STEM CELLS." Neuro-Oncology Advances 3, Supplement_1 (2021): i7. http://dx.doi.org/10.1093/noajnl/vdab024.027.

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Abstract INTRODUCTION Emerging evidence suggest that, in addition to glucose, fatty acids can also drive glioma growth. Increased lipid synthesis is one of the metabolic hallmarks of cancer, and indeed, unsaturated fatty acids (UFA) are particularly abundant in glioblastoma. However, the exact role of fatty acids in GBM tumors remains unclear. Blocking fatty acids synthesis can present a new therapy for GBM. METHODS Through targeted inhibitors screening on glioma stem cells (GSCs), we found that they are highly susceptible to Stearoyl CoA Desaturase 1 (SCD1) inhibitors. SCD1 is a key enzyme re

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Chen, Jiaping, Yangwei Wang, Wangyang Meng, et al. "Stearoyl-CoA Desaturases1 Accelerates Non-Small Cell Lung Cancer Metastasis by Promoting Aromatase Expression to Improve Estrogen Synthesis." International Journal of Molecular Sciences 24, no. 7 (2023): 6826. http://dx.doi.org/10.3390/ijms24076826.

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Metastases contribute to the low survival rate of non-small cell lung cancer (NSCLC) patients. Targeting lipid metabolism for anticancer therapies is attractive. Accumulative evidence shows that stearoyl-CoA desaturases1 (SCD1), a key enzyme in lipid metabolism, enables tumor metastasis and the underlying mechanism remains unknown. In this study, immunohistochemical staining of 96 clinical specimens showed that the expression of SCD1 was increased in tumor tissues (p < 0.001). SCD1 knockdown reduced the migration and invasion of HCC827 and PC9 cells in transwell and wound healing assays. Ar

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Olichwier, Adam, Volodymyr V. Balatskyi, Marcin Wolosiewicz, James M. Ntambi, and Pawel Dobrzyn. "Interplay between Thyroid Hormones and Stearoyl-CoA Desaturase 1 in the Regulation of Lipid Metabolism in the Heart." International Journal of Molecular Sciences 22, no. 1 (2020): 109. http://dx.doi.org/10.3390/ijms22010109.

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Stearoyl-CoA desaturase 1 (SCD1), an enzyme that is involved in the biosynthesis of monounsaturated fatty acids, induces the reprogramming of cardiomyocyte metabolism. Thyroid hormones (THs) activate both lipolysis and lipogenesis. Many genes that are involved in lipid metabolism, including Scd1, are regulated by THs. The present study used SCD1 knockout (SCD1−/−) mice to test the hypothesis that THs are important factors that mediate the anti-steatotic effect of SCD1 downregulation in the heart. SCD1 deficiency decreased plasma levels of thyroid-stimulating hormone and thyroxine and the expre

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Ralston, Jessica C. "Elucidating the roles of stearoyl-CoA desaturase 1 in adipocyte fatty acid metabolism and cellular function." Applied Physiology, Nutrition, and Metabolism 40, no. 12 (2015): 1313. http://dx.doi.org/10.1139/apnm-2015-0498.

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Worldwide obesity rates have risen to epidemic proportions, with over 600 million obese individuals across the globe. These individuals are prone to obesity-related health complications, including type 2 diabetes, hypertension, cancer, and cardiovascular disease. Obesity also coincides with the expansion of adipose tissue, which has an important role storing excess calories in the form of triacylglycerol (TAG) within adipocyte lipid droplets. The predominant fatty acids (FAs), comprising adipocyte TAGs, are monounsaturated FAs, which are produced by stearoyl-CoA desaturase 1 (SCD1). Specifical

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Rezamand, Pedram, Jason S. Watts, Katherine M. Yavah, et al. "Relationship between stearoyl-CoA desaturase 1 gene expression, relative protein abundance, and its fatty acid products in bovine tissues." Journal of Dairy Research 81, no. 3 (2014): 333–39. http://dx.doi.org/10.1017/s0022029914000181.

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Stearoyl-CoA desaturase 1 (SCD1) greatly contributes to the unsaturated fatty acids present in milk and meat of cattle. The SCD1 enzyme introduces a double bond into certain saturated fatty acyl-CoAs producing monounsaturated fatty acids (MUFA). The SCD1 enzyme also has been shown to be active in the bovine mammary gland converting t11 18 : 1 (vaccenic acid) to c9 t11 conjugated linoleic acid (CLA). The objective of this study was to determine any association between the gene expression of SCD1 and occurrence of its products (c9 14 : 1, c9 16 : 1, c9 18 : 1, and c9 t11 18 : 2) in various bovin

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Petroff, Anna B., Rebecca L. Weir, Charles R. Yates, Joseph D. Ng, and Jerome Baudry. "Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding and Unbinding Mechanism: A Computational Study." Biomolecules 11, no. 10 (2021): 1435. http://dx.doi.org/10.3390/biom11101435.

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Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum protein converts saturated fatty acids into monounsaturated fatty acids, primarily stearoyl-CoA into oleoyl-CoA, which are critical products for energy metabolism and membrane composition. The present computational molecular dynamics study characterizes the molecular dynamics of SCD1 with substrate, product, and as an apoprote

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Berthelot, V., L. Bernard, C. Richard, P. Chavatte-Palmer, and Y. Heyman. "44 MUSCLE FATTY ACID COMPOSITION AND LIPOGENIC GENE EXPRESSION IN ADULT BOVINE CLONES AND CONTROL CATTLE." Reproduction, Fertility and Development 22, no. 1 (2010): 179. http://dx.doi.org/10.1071/rdv22n1ab44.

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Previous evaluation of milk and meat from clone cattle compared with AI control cows indicated that these products were in the normal range of data, but slight differences were observed in their fatty acid (FA) composition and muscle Δ9-desaturase indexes (Heyman et al. 2007 Animal 1, 936-972). It was therefore hypothesized that epigenic modifications induced by the nuclear transfer technology may affect the expression of the 2 genes [stearoyl-coenzyme A desaturase (SCD)-1, SCD5] responsible for Δ9-desaturation in bovines. The aim of the present experiment was to analyze the differences betwee

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Bai, Wenzhe, Qianhai Fang, Yanzhen Bi, et al. "Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells." Animals 15, no. 11 (2025): 1663. https://doi.org/10.3390/ani15111663.

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Fat deposition plays a key role in determining porcine meat quality traits, with lipid droplets serving as critical organelles for lipid storage in adipose tissue. Inhibiting lipid droplet biogenesis disrupts the lipid storage capacity of adipocytes. The Stearoyl-CoA Desaturase (SCD) family is crucial in regulating polyunsaturated fatty acid/monounsaturated fatty acid (PUFA/MUFA) composition, while its role in lipid droplet formation remains unclear. This study employed CRISPR/Cas9 to create SCD1-deficient porcine renal epithelial cells (PK15), enabling an investigation into SCD1’s role in fat

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Qin, Xian-Yang, and Soichi Kojima. "Inhibition of Stearoyl-CoA Desaturase-1 Activity Suppressed SREBP Signaling in Colon Cancer Cells and Their Spheroid Growth." Gastrointestinal Disorders 1, no. 1 (2019): 191–200. http://dx.doi.org/10.3390/gidisord1010014.

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Unsaturated fatty acids are critical in promoting colon tumorigenesis and its stemness. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipid desaturase associated with colon cancer cell proliferation and metastasis control. This study aims to evaluate the effects of SCD1 inhibition on colon cancer spheroid growth in a three-dimensional cell culture system. An analysis of clinical data showed that increased SCD1 gene expression in colon tumors was negatively correlated with the prognosis. A chemical inhibitor of SCD1, CAY10566, inhibited the growth of colon cancer cells in both monolayer a

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Tian, Huibin, Huimin Niu, Jun Luo, et al. "Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis." PeerJ 10 (September 14, 2022): e13945. http://dx.doi.org/10.7717/peerj.13945.

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Background Lipid synthesis is an indispensable process during embryo and growth development. Abnormal lipid synthesis metabolism can cause multiple metabolic diseases including obesity and hyperlipidemia. Stearoyl-Coenzyme A desaturase 1 (SCD1) is responsible for catalyzing the synthesis of monounsaturated fatty acids (MUFA) and plays an essential role in lipid metabolism. The aim of our study was to evaluate the effects of SCD1 on embryo development and lipid synthesis in a knockout mice model. Methods We used the CRISPR/Cas9 system together with microinjection for the knockout mouse model ge

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Dobrzyn, Agnieszka, Pawel Dobrzyn, Seong-Ho Lee та ін. "Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing β-oxidation in skeletal muscle". American Journal of Physiology-Endocrinology and Metabolism 288, № 3 (2005): E599—E607. http://dx.doi.org/10.1152/ajpendo.00439.2004.

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Stearoyl-CoA desaturase (SCD) has recently been shown to be a critical control point of lipid partitioning and body weight regulation. Lack of SCD1 function significantly increases insulin sensitivity in skeletal muscles and corrects the hypometabolic phenotype of leptin-deficient ob/ ob mice, indicating the direct antilipotoxic action of SCD1 deficiency. The mechanism underlying the metabolic effects of SCD1 mutation is currently unknown. Here we show that SCD1 deficiency reduced the total ceramide content in oxidative skeletal muscles (soleus and red gastrocnemius) by ∼40%. The mRNA levels a

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Mohammadzadeh, Fatemeh, Vahid Hosseini, Alireza Alihemmati, et al. "The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis." Journal of Renal and Hepatic Disorders 3, no. 1 (2019): 15–22. http://dx.doi.org/10.15586/jrenhep.2019.49.

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Stearoyl-coenzyme A desaturase 1 (SCD1) is a microsomal enzyme that controls fatty acid metabolism and is highly expressed in hepatocytes. SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturated fatty acids into monounsaturated fatty acids. Imbalanced activity of SCD1 has been implicated in fatty liver induction, inflammation and stress. In this review, the role of SCD1 in hepatic development, function and pathogenesis is discussed. Additionally, emerging novel therapeutic agents targetin

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Dobosz, Aneta M., Justyna Janikiewicz, Anna M. Borkowska та ін. "Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells". International Journal of Molecular Sciences 21, № 18 (2020): 6844. http://dx.doi.org/10.3390/ijms21186844.

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Metabolic stress, such as lipotoxicity, affects the DNA methylation profile in pancreatic β-cells and thus contributes to β-cell failure and the progression of type 2 diabetes (T2D). Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme that is involved in monounsaturated fatty acid synthesis, which protects pancreatic β-cells against lipotoxicity. The present study found that SCD1 is also required for the establishment and maintenance of DNA methylation patterns in β-cells. We showed that SCD1 inhibition/deficiency caused DNA hypomethylation and changed the methyl group distribution with

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Zhang, Haojian, and Shaoguang Li. "The Scd1 Gene Functions as a Tumor Suppressor In Leukemia Stem Cells." Blood 116, no. 21 (2010): 201. http://dx.doi.org/10.1182/blood.v116.21.201.201.

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Abstract Abstract 201 We have previously shown that the arachidonate 5-lipoxygenase gene (Alox5) functions as a critical regulator of leukemia stem cells (LSCs) in BCR-ABL-induced chronic myeloid leukemia (CML) in mice. The Alox5 pathway appears to represent a major molecular network in LSCs. Taking advantage of our DNA microarray analysis for the identification of critical genes regulated by BCR-ABL in LSCs, we identified a small group of candidate genes that likely play tumor suppressor roles in these stem cells, and among them, a gene called stearoyl-CoA desaturase 1 (Scd1), an endoplasmic

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Levitsky, A., V. Velichko, I. Selivanskaya, and A. Lapinskaya. "Effect of dietary fats on endogenous oleic acid biosynthesis in rat liver." Journal of Education, Health and Sport 12, no. 2 (2022): 262–73. http://dx.doi.org/10.12775/jehs.2022.12.02.028.

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Aim: Determine the effect of dietary fats with different fatty acid composition on the biosynthesis of oleic acid and its metabolic precursors in the liver . Methods: High linoleic sunflower oil (HLSO), high oleic sunflower oil (HOSO) and palm oil (PO) were used. Rats were fed a semi-synthetic fat-free diet (FFD) and fat diets containing 5 % of the above oils (instead of starch) for 30 days. Liver lipids were divided into 3 fractions: neutral lipids (NL), phospholipids (PL) and free fatty acids (FFA). The fatty acid composition of the fractions was determined by gas chromatography. The “

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Levitsky, A., V. Velichko, I. Selivanskaya, and A. Lapinskaya. "Effect of dietary fats on endogenous oleic acid biosynthesis in rat liver." Journal of Education, Health and Sport 12, no. 2 (2022): 262–73. http://dx.doi.org/10.12775/jehs.2022.12.02.028.

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Aim: Determine the effect of dietary fats with different fatty acid composition on the biosynthesis of oleic acid and its metabolic precursors in the liver . Methods: High linoleic sunflower oil (HLSO), high oleic sunflower oil (HOSO) and palm oil (PO) were used. Rats were fed a semi-synthetic fat-free diet (FFD) and fat diets containing 5 % of the above oils (instead of starch) for 30 days. Liver lipids were divided into 3 fractions: neutral lipids (NL), phospholipids (PL) and free fatty acids (FFA). The fatty acid composition of the fractions was determined by gas chromatography. The “

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Dobrzyn, Pawel, Harini Sampath, Agnieszka Dobrzyn, Makoto Miyazaki, and James M. Ntambi. "Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart." American Journal of Physiology-Endocrinology and Metabolism 294, no. 2 (2008): E357—E364. http://dx.doi.org/10.1152/ajpendo.00471.2007.

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Stearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes the synthesis of monounsaturated fatty acids (FA). SCD1 deficiency activates metabolic pathways that promote FA β-oxidation and decrease lipogenesis in liver. In the present study, we show that FA transport and oxidation are decreased, whereas glucose uptake and oxidation are increased in the heart of SCD1−/− mice. Protein levels of FA transport proteins such as FA translocase/CD36 and FA transport protein as well as activity of carnitine palmitoyltransferase 1, the rate-limiting enzyme for mitochondrial fat oxidation, were sig

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Ropka-Molik, K., J. Knapik, M. Pieszka, and T. Szmatoła. "The expression of the SCD1 gene and its correlation with fattening and carcass traits in sheep." Archives Animal Breeding 59, no. 1 (2016): 37–43. http://dx.doi.org/10.5194/aab-59-37-2016.

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Abstract. Stearoyl-CoA desaturase 1 (SCD1) is a critical enzyme that catalyzes the synthesis of monounsaturated fatty acids and is involved in several signaling pathways related to lipid metabolism. The objective of the present study was to estimate the expression of the SCD1 gene in three different ovine tissues strongly associated with lipid homeostasis. The SCD1 gene expression measurement was performed on three tissues (liver, subcutaneous fat, perirenal fat) originated from 15 old-type Polish Merino sheep. The SCD1 transcript abundance was evaluated based on the two most stable endogenous

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Zhao, Xiaoyang, Min Wang, Jingjing Liu та Xiong Su. "Stearoyl CoA Desaturase 1 and Inositol-Requiring Protein 1α Determine the Efficiency of Oleic Acid in Alleviating Silica Nanoparticle-Induced Insulin Resistance". Journal of Biomedical Nanotechnology 17, № 7 (2021): 1349–63. http://dx.doi.org/10.1166/jbn.2021.3109.

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Despite the widespread use of silica nanoparticles (SiNPs), their metabolic impact and mechanisms of action have not been well studied. Exposure to SiNPs induces insulin resistance (IR) in hepatocytes by endoplasmic reticulum (ER) stress via inositol-requiring protein 1α (IRE1α) activation of c-Jun N-terminal kinases (JNK). It has been well established that stearoyl CoA desaturase (SCD1) and its major product oleic acid elicited beneficial effects in restoring ER homeostasis. However, the potential coordination of SCD1 and IRE1α in determining SiNP regulation of insulin signaling is unclear. H

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Min, Jin-Young, and Do-Hee Kim. "Stearoyl-CoA Desaturase 1 as a Therapeutic Biomarker: Focusing on Cancer Stem Cells." International Journal of Molecular Sciences 24, no. 10 (2023): 8951. http://dx.doi.org/10.3390/ijms24108951.

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The dysregulation of lipid metabolism and alterations in the ratio of monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) have been implicated in cancer progression and stemness. Stearoyl-CoA desaturase 1 (SCD1), an enzyme involved in lipid desaturation, is crucial in regulating this ratio and has been identified as an important regulator of cancer cell survival and progression. SCD1 converts SFAs into MUFAs and is important for maintaining membrane fluidity, cellular signaling, and gene expression. Many malignancies, including cancer stem cells, have been reported to exhibit h

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Yamasaki, Tomohiro, Lumin Zhang, Tyrone Dowdy, Adrian Lita, Mark Gilbert, and Mioara Larion. "TAMI-37. STEAROYL-COA DESATURASE 1 IS ESSENTIAL FOR THE GROWTH OF IDH MUTANT GLIOMA." Neuro-Oncology 23, Supplement_6 (2021): vi206. http://dx.doi.org/10.1093/neuonc/noab196.821.

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Abstract BACKGROUND Increased de novo lipogenesis is a hallmark of cancer metabolism. In this study, we interrogated the role of de novo lipogenesis in IDH1 mutated glioma’s growth and identified the key enzyme, Stearoyl-CoA desaturase 1 (SCD1) that provides this growth advantage. MATERIALS ANDMETHODS We prepared genetically engineered glioma cell lines (U251 wild-type: U251WT and U251 IDHR132H mutant: U251RH) and normal human astrocytes (empty vector induced-NHA: NHAEV and IDHR132H mutant: NHARH). Lipid metabolic analysis was conducted by using LC-MS and Raman imaging microscopy. SCD1 express

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Peter, Andreas, Alexander Cegan, Silvia Wagner, et al. "Hepatic Lipid Composition and Stearoyl-Coenzyme A Desaturase 1 mRNA Expression Can Be Estimated from Plasma VLDL Fatty Acid Ratios." Clinical Chemistry 55, no. 12 (2009): 2113–20. http://dx.doi.org/10.1373/clinchem.2009.127274.

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Abstract Background: Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting step of monounsaturated fatty acid synthesis in humans and is an important player in triglyceride generation. SCD1 has been repeatedly implicated in the pathogenesis of metabolic and inflammatory diseases. Therefore it is of great importance to determine SCD1 activity in human samples. In this study we aimed to evaluate a hepatic SCD1 activity index derived from plasma VLDL triglyceride composition as a tool to estimate hepatic SCD1 expression in humans. Additionally, we further evaluated commonly used fatty ac

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Peng, Liying, Ge Bai, Chunzheng Wang, et al. "Proteomics Insights into the Gene Network of cis9, trans11-Conjugated Linoleic Acid Biosynthesis in Bovine Mammary Gland Epithelial Cells." Animals 12, no. 13 (2022): 1718. http://dx.doi.org/10.3390/ani12131718.

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The objective of the study was to elucidate the stearoyl-coenzyme A desaturase (SCD1)-dependent gene network of c9, t11-CLA biosynthesis in MAC-T cells from an energy metabolism perspective. The cells were divided into the CAY group (firstly incubated with CAY10566, a chemical inhibitor of SCD1, then incubated with trans-11-octadecenoic acid, (TVA)), the TVA group (only TVA), and the control group (without CAY, TVA). The c9, t11-CLA, and TVA contents were determined by gas chromatography. The mRNA levels of SCD1 and candidate genes were analyzed via real-time PCR. Tandem mass tag (TMT)-based q

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Dragos, Steven M., Karl F. Bergeron, Frédérik Desmarais, et al. "Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes." American Journal of Physiology-Cell Physiology 313, no. 3 (2017): C295—C304. http://dx.doi.org/10.1152/ajpcell.00097.2017.

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White adipose tissue (WAT) has a critical role in lipid handling. Previous work demonstrated that SCD1 is an important regulator of WAT fatty acid (FA) composition; however, its influence on the various interconnected pathways influencing WAT lipid handling remains unclear. Our objective was to investigate the role of SCD1 on WAT lipid handling using Scd1 knockout (KO) mice and SCD1-inhibited 3T3-L1 adipocytes by measuring gene, protein, and metabolite markers related to FA reesterification, glyceroneogenesis, and lipolysis. Triacylglycerol (TAG) content was higher in inguinal WAT (iWAT) from

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Zou, Ying, Yi-Na Wang, Hong Ma, et al. "SCD1 promotes lipid mobilization in subcutaneous white adipose tissue." Journal of Lipid Research 61, no. 12 (2020): 1589–604. http://dx.doi.org/10.1194/jlr.ra120000869.

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Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they are regulated deserves more explorations. In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous WAT (scWAT) responded to cold stimulation and was able to promote mobilization of triacylglycerol [TAG (triglyceride)]. In vitro studies showed that SCD1 promoted lipolysis in C3H10T1/2 white adipocytes. The lipolytic effect was contributed by one of SCD1’s products, oleic acid (OA). OA upregula

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Stamatikos, Alexis D., and Chad M. Paton. "Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism." American Journal of Physiology-Endocrinology and Metabolism 305, no. 7 (2013): E767—E775. http://dx.doi.org/10.1152/ajpendo.00268.2013.

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Stearoyl-CoA desaturase-1 (SCD1) converts saturated fatty acids (SFA) into monounsaturated fatty acids and is necessary for proper liver, adipose tissue, and skeletal muscle lipid metabolism. While there is a wealth of information regarding SCD1 expression in the liver, research on its effect in skeletal muscle is scarce. Furthermore, the majority of information about its role is derived from global knockout mice, which are known to be hypermetabolic and fail to accumulate SCD1's substrate, SFA. We now know that SCD1 expression is important in regulating lipid bilayer fluidity, increasing trig

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Zhang, Yahua, Xiaoyan Zhang, Lihong Chen, et al. "Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule." American Journal of Physiology-Renal Physiology 290, no. 5 (2006): F1065—F1073. http://dx.doi.org/10.1152/ajprenal.00131.2005.

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Liver X receptors (LXRs), including LXRα and LXRβ, are intracellular sterol sensors that regulate expression of genes controlling fatty acid and cholesterol absorption, excretion, catabolism, and cellular efflux. Because the kidney plays an important role in lipid metabolism and dyslipidemia accelerates renal damage, we investigated the effect of TO-901317, an LXR agonist, on the gene expression profile in mouse kidney. Treatment of C57 Bl/6 mice with TO-901317 (3 mg·kg−1·day−1) for 3 days resulted in 51 transcripts that were significantly regulated in the kidney. Among them, the stearoyl-CoA

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Huang, K. M., L. Gullberg, K. K. Nelson, C. J. Stefan, K. Blumer, and S. K. Lemmon. "Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast." Journal of Cell Science 110, no. 7 (1997): 899–910. http://dx.doi.org/10.1242/jcs.110.7.899.

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Clathrin is a major coat protein involved in sorting and retention of proteins at the late Golgi and in endocytosis from the cell surface. The clathrin triskelion contains three heavy chains, which provide the structural backbone of the clathrin lattice and three light chains, which are thought to regulate the formation or disassembly of clathrin coats. To better understand the function of the clathrin light chain, we characterized yeast strains carrying a disruption of the clathrin light chain gene (CLC1). Light chain-deficient cells showed phenotypes similar to those displayed by yeast that

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Yu, Yeongji, Hyejin Kim, SeokGyeong Choi, et al. "Targeting a Lipid Desaturation Enzyme, SCD1, Selectively Eliminates Colon Cancer Stem Cells through the Suppression of Wnt and NOTCH Signaling." Cells 10, no. 1 (2021): 106. http://dx.doi.org/10.3390/cells10010106.

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The elimination of the cancer stem cell (CSC) population may be required to achieve better outcomes of cancer therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel target for CSC-selective elimination in colon cancer. CSCs expressed more SCD1 than bulk cultured cells (BCCs), and blocking SCD1 expression or function revealed an essential role for SCD1 in the survival of CSCs, but not BCCs. The CSC potential selectively decreased after treatment with the SCD1 inhibitor in vitro and in vivo. The CSC-selective suppression was mediated through the induction of apoptosis. The mechanism l

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Lee, Dong-Kyung, Kwang-Hwan Choi, Jae Yeon Hwang, Jong-Nam Oh, Seung-Hun Kim, and Chang-Kyu Lee. "Stearoyl-coenzyme A desaturase 1 is required for lipid droplet formation in pig embryo." Reproduction 157, no. 3 (2019): 235–43. http://dx.doi.org/10.1530/rep-18-0556.

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Lipid droplets (LD) provide a source of energy, and their importance during embryogenesis has been increasingly recognized. In particular, pig embryos have larger amounts of intercellular lipid bilayers than other mammalian species, suggesting that porcine embryos are more dependent on lipid metabolic pathways. The objective of the present study was to detect the effect of stearoyl-coenzyme A desaturase 1 (SCD1) on LD formation and to associate these effects with the mRNA abundance of LD formation-related genes (SREBP, ARF1, COPG2, PLD1 and ERK2) in in vitro-produced porcine embryos. To determ

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Yu, Yeongji, Hyejin Kim, SeokGyeong Choi, et al. "Targeting a Lipid Desaturation Enzyme, SCD1, Selectively Eliminates Colon Cancer Stem Cells through the Suppression of Wnt and NOTCH Signaling." Cells 10, no. 1 (2021): 106. http://dx.doi.org/10.3390/cells10010106.

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The elimination of the cancer stem cell (CSC) population may be required to achieve better outcomes of cancer therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel target for CSC-selective elimination in colon cancer. CSCs expressed more SCD1 than bulk cultured cells (BCCs), and blocking SCD1 expression or function revealed an essential role for SCD1 in the survival of CSCs, but not BCCs. The CSC potential selectively decreased after treatment with the SCD1 inhibitor in vitro and in vivo. The CSC-selective suppression was mediated through the induction of apoptosis. The mechanism l

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Hilmia, N., R. R. Noor, C. Sumantri, R. E. Gurnadi, and R. Priyanto. "Polymorphism of stearoyl-CoA desaturase (SCD1) gene in Indonesian local cattle." Journal of the Indonesian Tropical Animal Agriculture 42, no. 1 (2017): 1. http://dx.doi.org/10.14710/jitaa.42.1.1-5.

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Stearoyl-Coa desaturase (SCD1) gene is one of genes that involves in converting saturated fatty acids to unsaturated fatty acids. SNP at exon 5 in SCD1 gene that changes amino acid valine to alanine (V293A) has an influence to meat fatty acid composition. The aim of this research was to analyze SCD1 gene polymorphisms based on SNP V293A at exon 5 of three Indonesian local cattle. The identification of SCD1 gene polymorphisms was done by using 98, 20 and 7 DNA sample from Ciamis, Bali/Banteng, and Ongole Grade (PO) cattle, respectively. PCR_RFLP method with AciI enzim was carried out to identif

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Yamasaki, Tomohiro, Adrian Lita, Lumin Zhang, et al. "BIMG-10. IDH1 MUTATIONS INDUCE ORGANELLE DEFECTS VIA DYSREGULATED PHOSPHOLIPIDS." Neuro-Oncology Advances 3, Supplement_1 (2021): i3. http://dx.doi.org/10.1093/noajnl/vdab024.009.

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Abstract BACKGROUND Metabolic alterations of lipids have been identified as a hallmark of neoplasms, with the most prevalent being the balance between saturated fatty acid (SFA) and monosaturated fatty acid (MUFA). Stearoyl-CoA desaturase1 (SCD1), converting SFA to MUFA, is increased in many cancers, leading to worse prognosis. In glioma, the role of SCD1 remains unknown. Isocitrate dehydrogenase (IDH) mutations have been most commonly observed in glioma, but the involvement of mutant IDH in SCD1 expression also remains unknown. METHODS We conducted metabolic analysis to examine the alteration

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Peter, Andreas, Alexander Cegan, Silvia Wagner, et al. "Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans." American Journal of Physiology-Endocrinology and Metabolism 300, no. 2 (2011): E321—E326. http://dx.doi.org/10.1152/ajpendo.00306.2010.

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Stearoyl-CoA desaturase-1 (SCD1) has gained much interest as a future drug target to treat fatty liver and its consequences. However, there are few and inconsistent human data about expression and activity of this important enzyme. We investigated activity and expression of SCD1 and their relationships with liver fat (LF) content in human liver samples. Fifty subjects undergoing liver surgery were studied. SCD1 activity was estimated from the ratio of oleate (C18:1) to stearate (C18:0) within lipid subfractions. Furthermore, SCD1 mRNA expression and LF content were measured. Similarly to previ

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Guo, Yanyan, Zibo Xiong, Meiling Su, et al. "Positive association of SCD1 genetic variation and metabolic syndrome in dialysis patients in China." Personalized Medicine 17, no. 2 (2020): 111–19. http://dx.doi.org/10.2217/pme-2019-0020.

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Aim: Metabolic syndrome (MetS) diagnosed in the dialysis patients is increasingly reported which worsens the prognosis of the renal diseases. The relationship of SCD1 with MetS is largely unknown. The purpose of this study was to investigate the relationship between SCD1 polymorphism and MetS in dialysis patients. Methods: A cross-sectional study was conducted on 323 Chinese dialysis patients, and the correlation between the seven SNPs of SCD1 gene (rs10883465, rs2060792, rs1502593, rs522951, rs3071, rs3978768 and rs1393492) and MetS was analyzed. Results: One tag-SNP (rs1393492) has significa

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Binczek, Erika, Britta Jenke, Barbara Holz, Robert Heinz Günter, Mario Thevis, and Wilhelm Stoffel. "Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 -/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation." Biological Chemistry 388, no. 4 (2007): 405–18. http://dx.doi.org/10.1515/bc.2007.046.

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Abstract Targeted deletion of the stearoyl-CoA desaturase 1 gene (scd1) in mouse causes obesity resistance and a severe skin phenotype. Here, we demonstrate that SCD1 deficiency disrupts the epidermal lipid barrier and leads to uncontrolled transepidermal water loss, breakdown of adaptive thermoregulation and cold resistance, as well as a metabolic wasting syndrome. The loss of ω-hydroxylated very long-chain fatty acids (VLCFA) and ceramides substituted with ω-hydroxylated VLCFA covalently linked to corneocyte surface proteins leads to the disruption of the epidermal lipid barrier in scd1 -/-

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Forney, Laura A., Kirsten P. Stone, Desiree Wanders, James M. Ntambi, and Thomas W. Gettys. "The role of suppression of hepatic SCD1 expression in the metabolic effects of dietary methionine restriction." Applied Physiology, Nutrition, and Metabolism 43, no. 2 (2018): 123–30. http://dx.doi.org/10.1139/apnm-2017-0404.

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Dietary methionine restriction (MR) produces concurrent increases in energy intake and expenditure, but the proportionately larger increase in energy expenditure (EE) effectively limits weight gain and adipose tissue accretion over time. Increased hepatic fibroblast growth factor-21 (FGF21) is essential to MR-dependent increases in EE, but it is unknown whether the downregulation of hepatic stearoyl-coenzyme A desaturase-1 (SCD1) by MR could also be a contributing factor. Global deletion of SCD1 mimics cold exposure in mice housed at 23 °C by compromising the insular properties of the skin. Th

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