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Dissertations / Theses on the topic 'Secretion stress'

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Published: 22 June 2024

Last updated: 31 July 2025

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1

Smart, Darren. "Stressors & LH secretion in the ewe." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333607.

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2

Parker, Victoria Joanne. "Hypothalamic mechanisms mediating inhibition of prolactin secretion following stress in early pregnant mice." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6485.

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In early pregnancy prolonged exposure to stress is known to have profound adverse effects on reproduction and is associated with suppressed progesterone secretion and consequent disturbance of the pregnancy-protective cytokine milieu, thus threatening early pregnancy maintenance. Maternal neuroendocrine responses to stress in early pregnancy are poorly understood. Therefore, we designed experiments to (1) study the hypothalamo-pituitary-adrenal (HPA) axis responses to stress in early pregnant mice, to discover whether and how responses change and (2) to determine the effect of stress in early

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3

Kim, Beob Gyun. "INFLUENCES OF CHROMIUM (III) PICOLINATE ON PIGS UNDER THERMAL, IMMUNE OR DIETARY STRESS, AND ON ADRENAL STEROID SECRETION." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/560.

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The objectives were to investigate the effects of chromium (III) picolinate (CrPic; up to 2,000 ppb of Cr) on growing pigs subjected to a variety of stressors including thermal, immune, or dietary stress and to examine the effects of CrPic on steroidogenesis from adrenocortical cells. In the thermal stress study, high ambient temperature caused reduced weight gain and feed consumption (P andlt; 0.01), and low ambient temperature caused increased feed intake and feed:gain (P andlt; 0.01). However, these effects were not moderated by CrPic, and respiratory rate, plasma cortisol, or plasma glucos

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Kosti, Ourania. "Intra-adrenal mechanisms in the control of steroid secretion and the response to stress." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411344.

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5

Weber, Barbara. "Stress response and virulence in Vibrio anguillarum." Doctoral thesis, Umeå : Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), Umeå universitet, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33269.

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6

Marin, Marie-France. "Immediate and delayed effects of stress on a reactivitated declarative long-term memory trace." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116034.

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In 1968, a study demonstrated that consolidated memories can be affected again if they are reactivated. Given the importance of the stress hormones glucocorticoids (GCs) on memory consolidation, the goal of the current study was to assess whether GCs had the capacity to affect a reactivated long-term memory and whether neutral and emotional memories were affected differently. At the first session, participants encoded a movie containing neutral and emotional scenes. Two days later, they recalled the story. Half of them were then exposed to a psychosocial stressor. Memory performance was assess

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Pilgrim, Kamala. "Mechanisms underlying cortisol reactivity to stress in low and high socioeconomic status individuals : role of naturally-occurring attentional biases." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116040.

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This Master's dissertation explored whether a rapid orienting of attention toward or away from social stress information during a restful state, relates to the magnitude of glucocorticoids (GC) released in response to a stressor, the Trier Social Stress Test (TSST). It also assessed whether childhood rearing in a low socioeconomic status (SES) context mediates this relationship. Subjects rested for 45 minutes during which time they completed a modified version of Posner's attention paradigm, comprising social stress words. Immediately following, participants were exposed to the stressor. Resul

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Valiquette, Luc François. "Association between self-reported childhood maltreatment and cortisol profiles in psychotic patients." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112314.

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Childhood maltreatment is extremely common in patients diagnosed with psychotic disorders. Moreover, it has been linked with impaired functioning of the Hypothalamic-Pituitary-Adrenal axis. Furthermore, abnormality of the HPA has been found in psychotic patients. Presence of childhood maltreatment could then explain why the HPA axis is dysfunctional in these subjects. Our objective was to clarify the role of childhood trauma in the cortisol profiles of psychotic patients. Thirty-one patients underwent assessments of childhood maltreatment. Diurnal cortisol and cortisol after a controlled psych

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9

Alharake, Jawad. "Study of genetic factors involved in enzyme secretion in hyperproductive strains of Trichoderma reesei." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASB061.

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Les combustibles fossiles sont un contributeur majeur au réchauffement climatique, et leur nature non renouvelable est un obstacle à la construction de sociétés durables. Dans ce contexte, les biocarburants de seconde génération se présentent comme une alternative attractive et plus respectueuse de l'environnement. Le processus de production de biocarburants de deuxième génération comprend plusieurs étapes incluant le prétraitement physico-chimique de la biomasse lignocellulosique (non comestible), l'hydrolyse enzymatique de la cellulose en glucose et par la fermentation de sucres simples en b

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Solà, Tapias Núria. "The involvement of the three main inflammatory bowel disease pathways and the secretion of trypsin proteolytic activity on intestinal epithelial cells." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30049/document.

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Les maladies inflammatoires chroniques de l'intestin (MICI) se caractérisent par une inflammation sévère de l'intestin grêle et du côlon et comprennent la maladie de Crohn (MC) et la rectocolite hémorragique (RCH). Les MICI sont des maladies complexes faisant intervenir des facteurs génétiques : certains senseurs bactériens, l'autophagie et le stress du réticulum endoplasmique. Un défaut de barrière de l'épithélium digestif est également fortement impliqué dans la physiopathologie du processus inflammatoire. La fonction barrière de l'épithélium digestif est assurée par plusieurs types cellulai

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11

Hickman, Cristina Fontes Lindemann. "Environmental factors affecting interferon-τ expression and secretion by in vitro produced bovine blastocysts". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4399.

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Interferon (IFN)τ is the luteotrophic signal in ruminants and is secreted by bovine blastocysts both in vivo and in vitro. IFNτ secretion is highly variable and its control is only partly understood. Most studies on the effects of environmental factors on IFNτ production have evaluated IFNτ production during the time of embryo elongation and attachment. There is less knowledge of how IFNτ production at the blastocyst stage is modulated. Therefore, the hypothesis of this thesis was that the amounts of IFNτ expressed and/or secreted by bovine blastocysts produced in vitro were modulated by envir

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12

Zimmermann, Ulrich, Konstanze Spring, Hans-Ulrich Wittchen, et al. "Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-110031.

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Familial risk and environmental stress promote the development of alcohol dependence. We investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders. Twenty-four high-risk subjects with a paternal history of alcoholism (PHA) and 16 family history negative (FHN) controls were evaluated. Psychosocial stress was induced by having subjects deliver a 5-min speech and mental arithmetics in front of an audience on separate days, after drinking either placebo or ethanol (0.6

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Gallo, Marco. "misc-1/OGC is a new stress response gene and regulator of apoptosis, germline stem cell proliferation and insulin secretion." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27092.

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The present work produced new insights on the function of an ascaroside molecule and a gene that affect formation of dauer larvae, a diapause stage in Caenorhabditis elegans. Our results indicate that the ascaroside daumone, although a component of the dauer pheromone, does not act through signalling pathways active in the cilia. Furthermore, daumone has toxic effects if the animals are exposed to dauer-inducing concentrations of the compound. This ascaroside is not able, by itself, to recapitulate the full spectrum of events that occur during dauer formation. We identified misc-1 (MItocho

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Zimmermann, Ulrich, Konstanze Spring, Hans-Ulrich Wittchen, et al. "Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers." Technische Universität Dresden, 2004. https://tud.qucosa.de/id/qucosa%3A26808.

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Familial risk and environmental stress promote the development of alcohol dependence. We investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders. Twenty-four high-risk subjects with a paternal history of alcoholism (PHA) and 16 family history negative (FHN) controls were evaluated. Psychosocial stress was induced by having subjects deliver a 5-min speech and mental arithmetics in front of an audience on separate days, after drinking either placebo or ethanol (0.6

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Hammer, Jared Louis. "Changes In Threonyl-Trna Synthetase Expression And Secretion In Response To Endoplasmic Reticulum Stress By Monensin In Ovarian Cancer Cells." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/764.

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Aminoacyl-tRNA synthetases (ARS) are a family of enzymes that catalyze the charging of amino acids to their cognate tRNA in an aminoacylation reaction. Many members of this family have been found to have secondary functions independent of their primary aminoacylation function. Threonyl-tRNA synthetase (TARS), the ARS responsible for charging tRNA with threonine, is secreted from endothelial cells in response to both vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α), and stimulates angiogenesis and cell migration. Here we show a novel experimental approach for studyi

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Madec, Iltud. "Effets du sémiochimique MHUSA (Mother Hens' Uropygial Secretion Analogue) sur le stress des poulets de chair : approches zootechnique, physiologique et comportementale." Phd thesis, Toulouse, INPT, 2008. http://oatao.univ-toulouse.fr/7819/1/madec.pdf.

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Constats et hypothèses L'Homme a détourné, et donc faussé, l'importance des relations mère/jeune. Les techniques de production actuelles sont telles que les poussins sont introduits dans des bâtiments d’élevage âgés d'un jour. Ils y sont élevés par lots homogènes jusqu'à leur abattage. A partir de la ponte, le contact avec la mère n'existe plus, ce qui peut modifier l'empreinte et le lien d'attachement. Certains comportements originels, issus de l’ancêtre du poulet actuel, sont encore fonctionnels, alors que d’autres sont déviants. Le stress, qui peut être caractérisé par différents indicateur

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Gumpper, Kristyn Nicole. "Maintaining Cardiac and Gastric Physiology: TRIM Proteins as Central Factors in Regulation of Organ Homeostasis at the Cellular Level." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563287863754715.

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Sá, Maria Joana Giraldes Pereira Côrte-Real Corrêa de. "Natural IgM secretion in health and disease : genetic control and role in type 1 diabetes." Doctoral thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2012. http://hdl.handle.net/10400.5/4232.

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Tese de Doutoramento em Ciências Veterinárias, especialidade de Ciências Biológicas e Biomédicas<br>Germline-encoded autoreactive natural antibodies (NAbs) of the IgM isotype are secreted and circulate as a result of basal immune system stimulation, and constitute an important first line of defense against microorganism invasion, bridging the innate and the adaptive immune responses. NAbs are mostly secreted by positively selected B1a cells, and have been claimed to have a protective role against autoimmunity. Nevertheless, NAbs binding to cell surface self-antigens could have implications in

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Patrick-Melin, Amy J. "Effect of 7 Days Aerobic Exercise on Insulin Sensitivity, Oxidative Stress, TLR2/TLR4 Cell Surface Expression and Cytokine Secretion in Sedentary Obese Adults." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1310918543.

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Roma, Leticia Prates. "Mecanismos moleculares do efeito citotoxico da dexametasona em linhagens de celulas beta e ilhotas pancreaticas." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314413.

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Orientador: Kleber Luiz de Araujo e Souza<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-13T09:13:30Z (GMT). No. of bitstreams: 1 Roma_LeticiaPrates_D.pdf: 1071638 bytes, checksum: 52777a4c39261ec7137298200cb2b319 (MD5) Previous issue date: 2009<br>Resumo:Introdução/Objetivos. A produção de espécies reativas de oxigênio (EROs) faz parte de diversos processos fisiológicos. Nos últimos anos, o aumento de EROs têm sido associado ao desenvolvimento de diversas doenças, dentre elas o Diabetes Mellitus Tipo 2. As células beta p

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Alvarenga, Santos Buiate Ester. "ESTABLISHMENT OF BIOTROPHY BY THE MAIZE ANTHRACNOSE PATHOGEN COLLETOTRICHUM GRAMINICOLA: USE OF BIOINFORMATICS AND TRANSCRIPTOMICS TO ADDRESS THE POTENTIAL ROLES OF SECRETION, STRESS RESPONSE, AND SECRETED PROTEINS." UKnowledge, 2015. http://uknowledge.uky.edu/plantpath_etds/17.

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Colletotrichum graminicola is a hemibiotrophic pathogen of maize that causes anthracnose leaf and stalk rot diseases. The pathogen penetrates the host and initially establishes an intracellular biotrophic infection, in which the hyphae are separated from the living host cell by a membrane that is elaborated by the host, apparently in response to pathogen signals. A nonpathogenic mutant (MT) of C. graminicola was generated that germinates and penetrates the host normally, but is incapable of establishing a normal biotrophic infection. The mutated gene is Cpr1, conserved in eukaryotes and predic

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Stewart, Benjamin J. "Characterization of the effects of the lipid peroxidation products 4-hydroxynonenal and 4-oxononenal on hepatic lipid accumulation, VLDL assembly, secretion, and microtubules : relevance to alcoholic liver disease /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Toxicology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 111-122). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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Botermans, Jos A. M. "Feeding environment for growing-finishing pigs : effects of competition for feed and feeding frequency on performance, behaviour, injuries, plasma cortisol and exocrine pancreatic secretion /." Alnarp : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5744-0.pdf.

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Khalili-Mahani, Najmeh 1971. "Observing the stressed brain : magnetic resonance imaging of the neural correlates of hypothalamic pituitary adrenal axis function." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115857.

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The Hypothalamic Pituitary Adrenal (HPA) axis is the coordinator of adaptive responses to physical and psychological stress. The central nervous system plays a key role in modulation of both basal and adaptive HPA axis functions. In fact, since long ago, animal studies have shown that acute and chronic exposure to glucocorticoids (a stress hormone released due to HPA axis activation, cortisol in humans) affects the function and the morphology of brain areas such as the hippocampus and the cingulate cortex. This thesis is based on novel neuroimaging methodologies used to investigate the interac

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Schulz, Simone [Verfasser], and Reinhold [Akademischer Betreuer] Läßle. "Validity and Maintenance of Binge Eating Disorder. Laboratory and naturalistic studies on the role of negative affect, stress-induced eating and cortisol secretion in obese women with BED / Simone Schulz ; Betreuer: Reinhold Läßle." Trier : Universität Trier, 2014. http://d-nb.info/119780692X/34.

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Kuehn, Carina Brigitte. "Développement et études comparatives de méthodes pour améliorer la survie et les fonctions de cellules productrices d'insuline et d'îlots pancréatiques endocriniens porcins en conditions de culture in vitro et de stress apoptotiques." Thèse, Université de Sherbrooke, 2014. http://hdl.handle.net/11143/5411.

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Résumé : Durant les dernières années, l’encapsulation d’îlots pancréatiques endocriniens a reçu une grande attention parce qu’elle pourrait constituer une solution pour diminuer les taux d'échecs des transplantations. Dans le contexte de la perte de la matrice extracellulaire (MEC) native des îlots lors de leur isolation et le rejet de greffes par le système immunitaire du receveur, cette thèse vise à améliorer la compréhension des interactions entre la MEC et les cellules des îlots pancréatiques endocriniens ainsi qu’à étudier les effets de stress apoptotiques associés à des éléments du systè

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Cerrato, Giulia. "Oleate : An Atypical Cellular Stress Inducer That Stalls Protein Secretion Oleate-Induced Aggregation of LC3 at the Trans-Golgi Network Is Linked to a Protein Trafficking Blockade A Genome-Wide RNA Interference Screen Disentangles the Golgi Tropism of LC3 Live Cell Imaging of LC3 Dynamics." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL023.

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Les diverses classes d’acides gras (chaines carbonées saturées ou cis-/trans- insaturées) influencent la physiologie au niveau de la cellule et de l’organisme de façon différente. Curieusement, ces catégories distinctes ont un effet important (mais différent) sur l’autophagie, le mécanisme intracellulaire de dégradation qui maintient l’homéostasie énergétique et protège les cellules contre le stress. L’oléate, l’acide gras cis-insaturé endogène et alimentaire le plus abondant, possède la propriété atypique d’induire une redistribution de la protéine LC3 (signe particulier d’autophagie) de mani

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Nyblom, Hanna K. "Glucotoxicity in Insulin-Producing β-Cells". Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8309.

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<p><b>Background and aims:</b> Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.</p><p><b>Materials and methods:</b> INS-1E cells were cultured for 5 days in 5.5, 11, 20 or 27 mM glucose in the presence or absence of AMPK-agonist AICAR. GSIS was determined from INS-1E cells and islets obtained from type 2 diabetes and control donors. Human islets and INS-1E cells were functionally characterized (GSIS) and prot

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Mühlhan, Markus, Ulrike Lüken, Jens Siegert, Hans-Ulrich Wittchen, Michael N. Smolka, and Clemens Kirschbaum. "Enhanced Sympathetic Arousal in Response to fMRI Scanning Correlates with Task Induced Activations and Deactivations." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127271.

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It has been repeatedly shown that functional magnetic resonance imaging (fMRI) triggers distress and neuroendocrine response systems. Prior studies have revealed that sympathetic arousal increases, particularly at the beginning of the examination. Against this background it appears likely that those stress reactions during the scanning procedure may influence task performance and neural correlates. However, the question how sympathetic arousal elicited by the scanning procedure itself may act as a potential confounder of fMRI data remains unresolved today. Thirty-seven scanner naive healthy su

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Mühlhan, Markus, Ulrike Lüken, Jens Siegert, Hans-Ulrich Wittchen, Michael N. Smolka, and Clemens Kirschbaum. "Enhanced Sympathetic Arousal in Response to fMRI Scanning Correlates with Task Induced Activations and Deactivations." Public Library of Science, 2013. https://tud.qucosa.de/id/qucosa%3A27292.

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It has been repeatedly shown that functional magnetic resonance imaging (fMRI) triggers distress and neuroendocrine response systems. Prior studies have revealed that sympathetic arousal increases, particularly at the beginning of the examination. Against this background it appears likely that those stress reactions during the scanning procedure may influence task performance and neural correlates. However, the question how sympathetic arousal elicited by the scanning procedure itself may act as a potential confounder of fMRI data remains unresolved today. Thirty-seven scanner naive healthy su

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Herson, Paco S. "Oxidative stress activates a novel non-selective cation channel in insulin-secreting cells." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265376.

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Single channel recordings from CRI-G1 insulin-secreting cells were used to characterize a novel ion channel. The presence of both Ca<sup>2+</sup> and β-NAD<sup>+</sup> at the cytoplasmic aspect of the membrane are required for channel activity. This is the first ion channel described which requires internal β-NAD<sup>+</sup> for activity (thus termed NS<sub>NAD</sub>). The channel was found to be permeable to all monovalent (Na<sup>+</sup>, K<sup>+ </sup>and Cs<sup>+</sup>) and divalent cations tested (Ca<sup>2+</sup>, Mg<sup>2+</sup>, Ba<sup>2+</sup>, and Mn<sup>2+</sup>). The slope conductan

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DeAngelis, Cara Marie. "Characterization of the Vibrio cholerae Phage Shock Protein Response." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556723496251854.

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Lipson, Kathryn L. "The Role of Endoplasmic Reticulum Stress Signaling in Pancreatic Beta Cells: a Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/363.

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Protein folding in the endoplasmic reticulum (ER) is essential for proper cellular function. However, the sensitive environment in the ER can be perturbed by both pathological processes as well as by physiological processes such as a large biosynthetic load placed on the ER. ER stress is a specific type of intracellular stress caused by the accumulation of immature or abnormal misfolded or unfolded proteins in the ER. Simply defined, ER stress is a disequilibrium between ER load and folding capacity. Cells have an adaptive response that counteracts ER stress called the "Unfolded Protein Respon

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Fonseca, Sonya G. "Role of WFS1 in Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/414.

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The endoplasmic reticulum (ER) is a multi-functional cellular compartment that functions in protein folding, lipid biosynthesis, and calcium homeostasis. Perturbations to ER function lead to the dysregulation of ER homeostasis, causing the accumulation of unfolded and misfolded proteins in the cell. This is a state of ER stress. ER stress elicits a cytoprotective, adaptive signaling cascade to mitigate stress, the Unfolded Protein Response (UPR). As long as the UPR can moderate stress, cells can produce the proper amount of proteins and maintain a state of homeostasis. If the UPR, however, is

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Oslowski, Christine M. "TXNIP is a Mediator of ER Stress-Induced β-Cell Inflammation and Apoptosis: A Dissertation". eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/611.

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Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. The pathogenesis of these diseases involves β-cell dysfunction and death. The primary function of β-cells is to tightly regulate the secretion, production, and storage of insulin in response to blood glucose levels. In order to manage insulin biosynthesis, β-cells have an elaborate endoplasmic reticulum (ER). The ER is an essential organelle for the proper processing and folding of proteins such as proinsulin. Proteins fold properly when the ER protein load balances with the ER folding capacity that handles thi

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Dugani, Aisha Mohammed. "Effects of dopamine agonists and antagonists on gastric acid secretion and stress ulcer formation." 1987. http://hdl.handle.net/1993/15446.

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Chou, Sheng-Hsia, and 周聖夏. "Effects of docosahexaenoic acid deficiency on stress-induced glucocorticoid secretion in adult male rats." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/44595451536292047639.

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碩士<br>國立臺灣大學<br>生理學研究所<br>101<br>Most previous studies have focused on rat docosahexaenoic acid (22:6n-3, DHA) deficiency created during brain development via maternal n-3 fatty acid-deficient diet from pregnancy and lactation on adult anxiety and depression behaviors. It has been suggested the anxiety and depression is associated with hypothalamic-pituitary-adrenal axis (HPA axis) responses. The aim of this study was to evaluate whether brain DHA deficiency during post-weaning period would enhance restrain-induced HPA axis responses and anxiety or depression-like behavior in adult male rats.

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Huang, Lih-Rong, and 黃麗榕. "Effect of L-Glutamic Acid on Gastric Secretion and Stress-induced Gastric Lesions -- an in Vivo Study." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/29291475582945156334.

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碩士<br>台北醫學大學<br>醫學研究所<br>83<br>The effects of L-glutamic acid (L-Glu) on gastric acid secretion were incestigated in vivo. All SD rats were anesthetized with sodium pentobarbital (45 mg/kg, i.p.) after 24 hrs of fasting. The trachea、esophagus、femoral vein and duodenum were catheterized. The stomach was flushed throuth the esophagus cannula via a peristaltic pump with normal saline at room temperature. Acid output was determined by titration (autotitrator VIT90, Radiometer Corp., Corpenhagen, Denmark) of the perfusate with 0.01N NaOH to pH 7.0. after basal secretions were collected for 30 min,

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Diamond, Scott Lee. "Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells." Thesis, 1990. http://hdl.handle.net/1911/16336.

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To test the hypothesis that wall shear stress generated by blood flow may regulate endothelial cell expression of blood clot dissolving proteins or vasoactive proteins, an in vitro perfusion system was used to expose human umbilical vein endothelial cell monolayers to well defined, laminar fluid flow. Protein production studies utilized immunoassays, while semi-quantitative studies of messenger RNA levels in a small numbers of cells required a reverse transcription/polymerase chain reaction technique. Secretion by endothelial cells of the two main regulators of the fibrinolytic (ie blood clot

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Subramaney, Ugasvaree. "Personality style, cortisol secretion and the inflammatory response to trauma exposure in a cohort of South African metro police cadets: a prospective, longitudinal study." Thesis, 2012. http://hdl.handle.net/10539/11051.

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Literature investigating trauma exposure, Posttraumatic stress disorder (PTSD) and cortisol secretion has produced conflicting results with regard to whether cortisol is increased or decreased. With trauma there is also a pro- inflammatory response which is intimately linked with the hypothalamic pituitary axis (HPA). The police population can offer useful information in this regard as they represent a sample that will undergo exposure to traumatic events as part of their normal duties. In South Africa few studies have examined biological correlates of the traumatic stress response in th

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Chen, Yu-Ting, and 陳育廷. "Role of oxidative stress in the development of mild portal endotoxemia-induced chronic hepatic inflammation and impairment of pancreatic insulin secretion." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/11640773136953732044.

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碩士<br>國防醫學院<br>生理學研究所<br>96<br>Portal endotoxemia has been considered as a key pathogenic factor in chronic hepatic inflammation, which have shown to highly associate with metabolic syndrome and type 2 diabetes. Our previous study demonstrated that low-dose intraportal endotoxin infusion could induce chronic hepatic inflammation and impair endocrine pancreatic function. This study was to further test the role of oxidative stress in the pathogenesis of the portal endotoxemia-induced damages in liver and pancreas. from normal rats and fructose-induced insulin resistant rats with fatty liver. Chr

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"Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and mitochondrial dysfunction." Thesis, 2010. http://library.cuhk.edu.hk/record=b6075047.

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Additionally, cyclosporin A, an inhibitor of the mitochondrial permeability transition (MPT) pore, failed to prevent hIAPP-induced DeltaPsim collapse, cytochrome c and AIF release and caspase-3 activation, indicating that the MPT pore was not involved in hIAPP-induced apoptosis. On the other hand, potential crosstalk between the extrinsic and intrinsic apoptotic pathways was demonstrated by cleavage of Bid by caspase-8 in the apoptotic process triggered by hIAPP.<br>It is widely accepted that human islet amyloid polypeptide (hIAPP) aggregation plays an important role in the loss of insulin-pro

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Barbeau, Annie. "Rôle de l'estérification des acides gras dans la régulation de la sécrétion d'insuline et le stress métabolique induits par le glucose." Thèse, 2012. http://hdl.handle.net/1866/7063.

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Le diabète est une maladie chronique de l’homéostasie du glucose caractérisée par une hyperglycémie non contrôlée qui est le résultat d’une défaillance de la sécrétion d’insuline en combinaison ou non avec une altération de l’action de l’insuline. La surnutrition et le manque d’activité physique chez des individus qui ont des prédispositions génétiques donnent lieu à la résistance à l’insuline. Pendant cette période dite de compensation où la concentration d’acides gras plasmatiques est élevée, l’hyperinsulinémie compense pleinement pour la résistance à l’insuline des tissus cibles et la glycé

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Narayanan, Niju. "Molecular and Genetic Strategies to Enhance Functional Expression of Recombinant Protein in Escherichia coli." Thesis, 2009. http://hdl.handle.net/10012/4721.

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The versatile Escherichia coli facilitates protein expression with relative simplicity, high cell density on inexpensive substrates, well known genetics, variety of expression vectors, mutant strains, co-overexpression technology, extracytoplasmic secretion systems, and recombinant protein fusion partners. Although, the protocol is rather simple for soluble proteins, heterologous protein expression is frequently encountered by major technical limitations including inefficient translation, formation of insoluble inclusion bodies, lack of posttranslational modification mechanisms, degradation by

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Décary, Simon. "Amélioration de la fonction pancréatique par l'activité physique chez le rat diabétique de type 2." Thèse, 2008. http://hdl.handle.net/1866/7740.

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