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Journal articles on the topic 'Secretion stress'

Author: Grafiati

Published: 22 June 2024

Last updated: 31 July 2025

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1

Seo, Jin, Anja Brencic, and Andrew J. Darwin. "Analysis of Secretin-Induced Stress in Pseudomonas aeruginosa Suggests Prevention Rather than Response and Identifies a Novel Protein Involved in Secretin Function." Journal of Bacteriology 191, no. 3 (2008): 898–908. http://dx.doi.org/10.1128/jb.01443-08.

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ABSTRACT Secretins are bacterial outer membrane proteins that are important for protein export. However, they can also mislocalize and cause stress to the bacterial cell, which is dealt with by the well-conserved phage shock protein (Psp) system in a highly specific manner. Nevertheless, some bacteria have secretins but no Psp system. A notable example is Pseudomonas aeruginosa, a prolific protein secretor with the potential to produce seven different secretins. We were interested in investigating how P. aeruginosa might deal with the potential for secretin-induced stress without a Psp system.

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Delbende, C., C. Delarue, H. Lefebvre, et al. "Glucocorticoids, Transmitters and Stress." British Journal of Psychiatry 160, S15 (1992): 24–35. http://dx.doi.org/10.1192/s0007125000296657.

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Many kinds of stress stimulate the neuroendocrine systems controlling catecholamine and glucocorticoid secretion. Stress-induced stimulation of CRF-containing neurons appears to be mediated by serotonergic, noradrenergic, and possibly other neuronal pathways. Stress can alter various neurobiological and endocrine functions, two essential components of the neuroendocrine responses being release of adrenalin from chromaffin cells of the adrenal medulla and secretion of glucocorticoids from adrenocortical cells. Activation of adrenal steroid secretion is mainly by a reflex activation of hypothala

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3

Cramer, Robert A. "Secretion stress and fungal pathogenesis." Virulence 2, no. 1 (2011): 1–3. http://dx.doi.org/10.4161/viru.2.1.13902.

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Aguiar, Tatiana Q., Orquídea Ribeiro, Mikko Arvas, Marilyn G. Wiebe, Merja Penttilä, and Lucília Domingues. "Investigation of protein secretion and secretion stress in Ashbya gossypii." BMC Genomics 15, no. 1 (2014): 1137. http://dx.doi.org/10.1186/1471-2164-15-1137.

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Zhang, Irina X., Jianhua Ren, Suryakiran Vadrevu, Malini Raghavan, and Leslie S. Satin. "ER stress increases store-operated Ca2+ entry (SOCE) and augments basal insulin secretion in pancreatic beta cells." Journal of Biological Chemistry 295, no. 17 (2020): 5685–700. http://dx.doi.org/10.1074/jbc.ra120.012721.

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Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum (ER) stress can lead to beta-cell apoptosis and has been linked to type 2 diabetes. Although many studies have attempted to link ER stress and T2DM, the specific effects of ER stress on beta-cell function remain incompletely understood. To determine the interrelationship between ER stress and beta-cell function, here we treated insulin-secreting INS-1(832/13) cells or isolated mouse islets with the ER stress–inducer tun

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Freeman, H., K. Shimomura, R. D. Cox, and F. M. Ashcroft. "Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress." Biochemical Society Transactions 34, no. 5 (2006): 806–10. http://dx.doi.org/10.1042/bst0340806.

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This paper reviews recent studies on the role of Nnt (nicotinamide nucleotide transhydrogenase) in insulin secretion and detoxification of ROS (reactive oxygen species). Glucose-stimulated insulin release from pancreatic β-cells is mediated by increased metabolism. This elevates intracellular [ATP], thereby closing KATP channels (ATP-sensitive potassium channels) and producing membrane depolarization, activation of voltage-gated Ca2+ channels, Ca2+ influx and, consequently, insulin secretion. The C57BL/6J mouse displays glucose intolerance and reduced insulin secretion, which results from a na

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Žarković, Miloš, Elka Stefanova, Jasmina Ćirić, et al. "Prolonged psychological stress suppresses cortisol secretion." Clinical Endocrinology 59, no. 6 (2003): 811–16. http://dx.doi.org/10.1046/j.1365-2265.2003.01925.x.

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Holtmann, Gerald, Reinholde Kriebel, and Manfred V. Singer. "Mental stress and gastric acid secretion." Digestive Diseases and Sciences 35, no. 8 (1990): 998–1007. http://dx.doi.org/10.1007/bf01537249.

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9

Giuliani, Fabrizio, Adam Grieve, and Catherine Rabouille. "Unconventional secretion: a stress on GRASP." Current Opinion in Cell Biology 23, no. 4 (2011): 498–504. http://dx.doi.org/10.1016/j.ceb.2011.04.005.

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Belay, Tesfaye, Alexis Ray, and Kaitlyn Cook. "Cytokine production profiles of immune cells of stressed beta2-adrenergic receptor knockout mouse model during Chlamydia muridarumgenital infection." Journal of Immunology 210, no. 1_Supplement (2023): 81.10. http://dx.doi.org/10.4049/jimmunol.210.supp.81.10.

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Abstract Chlamydia genital infection by Chlamydia trachomatisis the most common bacterial sexually transmitted disease worldwide. The relationships between stress and chlamydia genital infection remain unknown. Beta2-adrenergic receptor(β2-AR), the major receptor of the stress hormone norepinephrine (NE), is known to impair the function of immune cells. Stress was induced by immersing mice in cold water for five minutes daily for 21 days before infection. This study determined profiles of immune cells of stressed β2-AR KO and stressed WT C57BL/6J after 48 h of Chlamydia muridarumgenital infect

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Mani, Bharath K., Sherri Osborne-Lawrence, Nathan Metzger, and Jeffrey M. Zigman. "Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion." American Journal of Physiology-Endocrinology and Metabolism 319, no. 2 (2020): E330—E337. http://dx.doi.org/10.1152/ajpendo.00119.2020.

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Ghrelin is a predominantly stomach-derived peptide hormone with many actions including regulation of food intake, body weight, and blood glucose. Plasma ghrelin levels are robustly regulated by feeding status, with its levels increasing upon caloric restriction and decreasing after food intake. At least some of this regulation might be due to direct responsiveness of ghrelin cells to changes in circulating nutrients, including glucose. Indeed, oral and parental glucose administration to humans and mice lower plasma ghrelin. Also, dissociated mouse gastric mucosal cell preparations, which conta

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12

Wang, Guixue, Shaoxi Cai, Xiaoyan Deng, Keqing Ouyang, Guoming Xie, and Robert Guidoin. "Secretory response of endothelin‐1 in cultured human glomerular microvascular endothelial cells to shear stress." Biorheology: The Official Journal of the International Society of Biorheology 37, no. 4 (2000): 291–99. http://dx.doi.org/10.1177/0006355x2000037004004.

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The shear‐induced secretory response of endothelin‐1 (ET‐1) by human microvascular endothelial cells was studied using paired human glomerular microvascular endothelial cell (HGMEC) cultured monolayers exposed to steady‐state laminar shear stress for up to 10 hours. The first cell monolayer was subjected to a shear stress of 0.65 N m−2 and the second, 1.3 N m−2. ET‐1 secretion was determined by radioimmunoassay. Over 10 hours of shear, the total cumulative secretion of ET‐1 was 237.4 pg/cm2 for the monolayer exposed to 1.3 N m−2 and 143.6 pg/cm2 for the monolayer exposed to 0.65 N m−2. The ave

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Wang, Huan, Shuting Zhao, Zexin Qi, et al. "Regulation of Root Exudation in Wheat Plants in Response to Alkali Stress." Plants 13, no. 9 (2024): 1227. http://dx.doi.org/10.3390/plants13091227.

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Soil alkalization is an important environmental factor limiting crop production. Despite the importance of root secretion in the response of plants to alkali stress, the regulatory mechanism is unclear. In this study, we applied a widely targeted metabolomics approach using a local MS/MS data library constructed with authentic standards to identify and quantify root exudates of wheat under salt and alkali stresses. The regulatory mechanism of root secretion in alkali-stressed wheat plants was analyzed by determining transcriptional and metabolic responses. Our primary focus was alkali stress-i

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Turakulov, Ya Kh, R. B. Burikhanov, P. P. Patkhitdinov, and A. I. Myslitsksya. "Immobilization stress effect on thyroid hormone secretion." Problems of Endocrinology 39, no. 5 (1993): 47–48. http://dx.doi.org/10.14341/probl11990.

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Analysis of blood flowing from the rat thyroid has shown that an acute immobilization stress enhanced thyroid hormone secretion with an increase of the T3/T4-100 index. The most marked response to stress was observed after repeated 2 min immobilization with a 3 min interval: Such increase of secretion was arrested by injection of prasosin, an -adrenoblocker. Propylthiouracil injected an hour before the experiment reduced T4 thyroid conversion index. These results permit a conclusion that short-term repeated immobilization enhanced thyroid hormone secretion via -adrenergic system stimulation, t

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Bułdak, Łukasz, Estera Skudrzyk, Grzegorz Machnik, Aleksandra Bołdys, Rafał Jakub Bułdak, and Bogusław Okopień. "Exenatide improves antioxidant capacity and reduces the expression of LDL receptors and PCSK9 in human insulin-secreting 1.1E7 cell line subjected to hyperglycemia and oxidative stress." Postępy Higieny i Medycyny Doświadczalnej 76, no. 1 (2022): 16–23. http://dx.doi.org/10.2478/ahem-2021-0037.

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Abstract Introduction GLP-1 receptor agonists (e.g., exenatide) are novel drugs used in the treatment of diabetes. These drugs, working with other mechanisms of action, improve glycemic control by increasing secretion of insulin and improving survival of pancreatic islet beta cells. Alterations in the oxidative stress level or the expression of proteins associated with cholesterol uptake might be responsible for those findings. Currently, there are few in vitro studies on the impact of exenatide antioxidant capacity in human islet beta cell lines and none that assess the influence of exenatide

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Cornelius, Jamie M., Creagh W. Breuner, and Thomas P. Hahn. "Coping with the extremes: stress physiology varies between winter and summer in breeding opportunists." Biology Letters 8, no. 2 (2011): 312–15. http://dx.doi.org/10.1098/rsbl.2011.0865.

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Seasonal changes in stress steroid hormone secretions are thought to reflect investment in self-maintenance versus reproduction. The capricious conditions hypothesis (CCH) posits that reduced corticosterone (CORT) secretion during stress coincident with parental phases of breeding is necessary in harsh environments because a full response would otherwise trigger repeated nest abandonments. To test this hypothesis, we measured seasonal changes in stress physiology in free-living red crossbills ( Loxia curvirostra ), an opportunistically breeding songbird that regularly breeds in summer and wint

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17

Wirtz, Petra H., Roland von Känel, Changiz Mohiyeddini, et al. "Low Social Support and Poor Emotional Regulation Are Associated with Increased Stress Hormone Reactivity to Mental Stress in Systemic Hypertension." Journal of Clinical Endocrinology & Metabolism 91, no. 10 (2006): 3857–65. http://dx.doi.org/10.1210/jc.2005-2586.

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Abstract Context: There is strong evidence for a physiological hyperreactivity to stress in systemic hypertension, but data on associated or potentially moderating psychological factors are scarce. Objective: The objective of the study was to identify psychological correlates of physiological stress reactivity in systemic hypertension. Design: This was a cross-sectional, quasiexperimentally controlled study. Study participants underwent an acute standardized psychosocial stress task combining public speaking and mental arithmetic in front of an audience. Setting: The study was conducted in the

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18

Carew, Nolan, Ashley Nelson, Zhitao Liang, Sage Smith, and Christine Milcarek. "Linking Endoplasmic Reticular Stress and Alternative Splicing." International Journal of Molecular Sciences 19, no. 12 (2018): 3919. http://dx.doi.org/10.3390/ijms19123919.

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RNA splicing patterns in antibody-secreting cells are shaped by endoplasmic reticulum stress, ELL2 (eleven-nineteen lysine-rich leukemia gene 2) induction, and changes in the levels of snRNAs. Endoplasmic reticulum stress induces the unfolded protein response comprising a highly conserved set of genes crucial for cell survival; among these is Ire1, whose auto-phosphorylation drives it to acquire a regulated mRNA decay activity. The mRNA-modifying function of phosphorylated Ire1 non-canonically splices Xbp1 mRNA and yet degrades other cellular mRNAs with related motifs. Naïve splenic B cells wi

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19

Bridgeman, Stephanie, Gaewyn Ellison, Philip Newsholme та Cyril Mamotte. "The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I". International Journal of Molecular Sciences 22, № 24 (2021): 13330. http://dx.doi.org/10.3390/ijms222413330.

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Histone deacetylase (HDAC) inhibitors such as butyrate have been reported to reduce diabetes risk and protect insulin-secreting pancreatic β cells in animal models. However, studies on insulin-secreting cells in vitro have found that butyrate treatment resulted in impaired or inappropriate insulin secretion. Our study explores the effects of butyrate on insulin secretion by BRIN BD-11 rat pancreatic β cells and examined effects on the expression of genes implicated in β cell function. Robust HDAC inhibition with 5 mM butyrate or trichostatin A for 24 h in β cells decreased basal insulin secret

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20

Kar, Louis D. "FOREBRAIN PATHWAYS MEDIATING STRESS-INDUCED RENIN SECRETION." Clinical and Experimental Pharmacology and Physiology 23, no. 2 (1996): 166–70. http://dx.doi.org/10.1111/j.1440-1681.1996.tb02591.x.

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21

Copper, Rachel L., and Robert L. Goldenberg. "Catecholamine Secretion in Fetal Adaptation to Stress." Journal of Obstetric, Gynecologic & Neonatal Nursing 19, no. 3 (1990): 223–26. http://dx.doi.org/10.1111/j.1552-6909.1990.tb01640.x.

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22

Oberbeck, R., R. J. Benschop, R. Jacobs, et al. "Endocrine mechanisms of stress-induced DHEA-secretion." Journal of Endocrinological Investigation 21, no. 3 (1998): 148–53. http://dx.doi.org/10.1007/bf03347293.

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23

Van de Kar, Louis D., and Martha L. Blair. "Forebrain Pathways Mediating Stress-Induced Hormone Secretion." Frontiers in Neuroendocrinology 20, no. 1 (1999): 1–48. http://dx.doi.org/10.1006/frne.1998.0172.

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24

Shen, Hong, Weibin Jing, Tiancheng Ai, Ying Lu, and Jianxun Cheng. "Differential secretion of lactate and activity of plasma membrane H+-ATPase in the roots of soybean seedlings in response to low-oxygen stress." Australian Journal of Botany 54, no. 5 (2006): 471. http://dx.doi.org/10.1071/bt05141.

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Plants display a series of tolerance mechanism following exposure to low-oxygen stress. Increased secretion of end production of carbohydrate catabolism and synthesis of stress-related proteins are important mechanisms enabling the plant to develop tolerance to anoxia stress. In this study, the secretion of lactate and the activity of plasma membrane H+-ATPase in a wild-type (WTS) and a cultivated soybean (CTS) were investigated in response to low-oxygen stress. Low oxygen (0.1% O2, anoxia) increased the secretion of lactate and reduced the activity of plasma membrane H+-ATPase and ATP content

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Masumi, Kamiyama, Ookawa Mana, Saito Rika, et al. "Isoflavones Inhibit Hydrogen Peroxide-Induced Angiotensinogen Secretion in Mesangial Cells." Current Topics in Nutraceutical Research 22, no. 2 (2024): 624–28. http://dx.doi.org/10.37290/ctnr2641-452x.22:624-628.

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The mechanisms underlying increased angiotensinogen secretion in diabetic nephropathy are unknown. This study aimed to examine the mechanism of increased angiotensinogen secretion in mesangial cells. Additionally, we explored the effects of antioxidant compounds, such as isoflavones, on angiotensin secretion. Angiotensinogen expression and secretion were evaluated in mesangial cells treated with hydrogen peroxide. We investigated the effects of pretreatment with catalase, daidzein, and equol and inhibitors of mitogen-activated protein kinase, stress-stimulated kinase p38, or c-Jun NH2-terminal

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1Bhubaneswar, Sahoo and 2Digneshkumar Patel. "Effect Of Stress on Cattle Reproduction." Science World a monthly e magazine 2, no. 11 (2022): 1850–53. https://doi.org/10.5281/zenodo.7342570.

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Stress has been reported to influence the animal reproduction adversely. The impact of stress on reproduction depends on the type of stress, genetic predisposition of the animals, timing and duration of the stress. It inhibits GnRH/gonadotropin secretion in hypothalamus-pituitary-adrenal (HPA) axis through secretion of Adrenocorticotropin (ACTH), glucocorticoids (GH) and catecholamine (CA). With a better understanding of the basic biology and altered physiological processes involved in stress adaptability, it would be possible to devise strategies for animal welfare and optimal production.

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Szczepanska-Sadowska, Ewa, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, and Tymoteusz Żera. "Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation." International Journal of Molecular Sciences 22, no. 21 (2021): 11465. http://dx.doi.org/10.3390/ijms222111465.

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The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volum

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Bataille, Amy M., Carla L. Maffeo, and J. Larry Renfro. "Avian renal proximal tubule urate secretion is inhibited by cellular stress-induced AMP-activated protein kinase." American Journal of Physiology-Renal Physiology 300, no. 6 (2011): F1327—F1338. http://dx.doi.org/10.1152/ajprenal.00680.2010.

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Urate is a potent antioxidant at high concentrations but it has also been associated with a wide variety of health risks. Plasma urate concentration is determined by ingestion, production, and urinary excretion; however, factors that regulate urate excretion remain uncertain. The objective of this study was to determine whether cellular stress, which has been shown to affect other renal transport properties, modulates urate secretion in the avian renal proximal tubule. Chick kidney proximal tubule epithelial cell primary culture monolayers were used to study the transepithelial transport of ra

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Newman, Jonathon R., and Diane Wagner. "The influence of water availability and defoliation on extrafloral nectar secretion in quaking aspen (Populus tremuloides)." Botany 91, no. 11 (2013): 761–67. http://dx.doi.org/10.1139/cjb-2013-0147.

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In recent years, water stress has led to widespread growth declines and dieback of several North American tree species. In addition to its direct effects on tree physiology, water stress may compromise anti-herbivore defenses. We tested whether extrafloral (EF) sugar secretion rate in Populus tremuloides Michx. (quaking aspen) increases in response to defoliation and whether water stress impairs constitutive and inducible EF sugar secretion. We subjected P. tremuloides ramets of four genotypes to water restriction and defoliation in a factorial design and measured EF sugar secretion rates 2, 4

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Lee, Younghay, Sun-Hye Shin, Kyung-Ah Cho, et al. "Administration of Tonsil-Derived Mesenchymal Stem Cells Improves Glucose Tolerance in High Fat Diet-Induced Diabetic Mice via Insulin-Like Growth Factor-Binding Protein 5-Mediated Endoplasmic Reticulum Stress Modulation." Cells 8, no. 4 (2019): 368. http://dx.doi.org/10.3390/cells8040368.

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Type 2 diabetes mellitus (T2DM) is a prevalent chronic metabolic disorder accompanied by high blood glucose, insulin resistance, and relative insulin deficiency. Endoplasmic reticulum (ER) stress induced by high glucose and free fatty acids has been suggested as one of the main causes of β-cell dysfunction and death in T2DM. Stem cell-derived insulin-secreting cells were recently suggested as a novel therapy for diabetes. In the present study, we demonstrate the therapeutic potential of tonsil-derived mesenchymal stem cells (TMSCs) to treat high-fat diet (HFD)-induced T2DM. To explore whether

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Zinkevičiūtė, Rūta, Raimundas Ražanskas, Algirdas Kaupinis, et al. "Yeast Secretes High Amounts of Human Calreticulin without Cellular Stress." Current Issues in Molecular Biology 44, no. 5 (2022): 1768–87. http://dx.doi.org/10.3390/cimb44050122.

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The ER chaperone calreticulin (CALR) also has extracellular functions and can exit the mammalian cell in response to various factors, although the mechanism by which this takes place is unknown. The yeast Saccharomyces cerevisiae efficiently secretes human CALR, and the analysis of this process in yeast could help to clarify how it gets out of eukaryotic cells. We have achieved a secretion titer of about 140 mg/L CALR in our S. cerevisiae system. Here, we present a comparative quantitative whole proteome study in CALR-secreting yeast using non-equilibrium pH gradient electrophoresis (NEPHGE)-b

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Hannibal, Kara E., and Mark D. Bishop. "Chronic Stress, Cortisol Dysfunction, and Pain: A Psychoneuroendocrine Rationale for Stress Management in Pain Rehabilitation." Physical Therapy 94, no. 12 (2014): 1816–25. http://dx.doi.org/10.2522/ptj.20130597.

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Pain is a primary symptom driving patients to seek physical therapy, and its attenuation commonly defines a successful outcome. A large body of evidence is dedicated to elucidating the relationship between chronic stress and pain; however, stress is rarely addressed in pain rehabilitation. A physiologic stress response may be evoked by fear or perceived threat to safety, status, or well-being and elicits the secretion of sympathetic catecholamines (epinephrine and norepinepherine) and neuroendocrine hormones (cortisol) to promote survival and motivate success. Cortisol is a potent anti-inflamm

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Saito, Takatoshi, Hiroshi Itoh, Tae-Hwa Chun, et al. "Coordinate regulation of endothelin and adrenomedullin secretion by oxidative stress in endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 281, no. 3 (2001): H1364—H1371. http://dx.doi.org/10.1152/ajpheart.2001.281.3.h1364.

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To elucidate the significance of oxidative stress in the modulation of endothelial functions, we examined the effects of H2O2 on the expression of two endothelium-derived vasoactive peptides, endothelin (ET) and adrenomedullin (Am), and their interaction. H2O2 dose dependently suppressed ET secretion and ET-1 mRNA expression in bovine carotid endothelial cells (ECs). Menadion sodium bisulfate, a redox cycling drug, also decreased ET secretion in a dose-dependent manner. Catalase, a H2O2 reductase, and dl-α-tocopherol (vitamin E) significantly inhibited H2O2-induced suppression of ET secretion.

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Ponikowska, Irena, Przemysław Adamczyk, and Irena Krupka-Matuszczyk. "Thermal Therapy In Patients with Post-pandemic Stress Syndrome as a S upporting Therapy." Acta Balneologica 62, no. 4 (2020): 245–49. http://dx.doi.org/10.36740/abal202004108.

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The viral pandemic causes multidirectional adverse effects and the greatest of which is health. The viral infection itself and severe infectious disease with pulmonary complications are of government concern. However, less is said about the effects of pandemic restrictions, e.g., social isolation leading to a series of severe psychosomatic disorders. In social isolation and quarantine, the classic negative lifestyle factors are working – the lack of exercise, excessive eating, stress, and addiction intensity. In turn, these factors lead to the exacerbation of chronic diseases such as diabetes,

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Breen, Kellie M., Amy E. Oakley, Andrew V. Pytiak, Alan J. Tilbrook, Elizabeth R. Wagenmaker, and Fred J. Karsch. "Does Cortisol Acting Via the Type II Glucocorticoid Receptor Mediate Suppression of Pulsatile Luteinizing Hormone Secretion in Response to Psychosocial Stress?" Endocrinology 148, no. 4 (2007): 1882–90. http://dx.doi.org/10.1210/en.2006-0973.

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This study assessed the importance of cortisol in mediating inhibition of pulsatile LH secretion in sheep exposed to a psychosocial stress. First, we developed an acute psychosocial stress model that involves sequential layering of novel stressors over 3–4 h. This layered-stress paradigm robustly activated the hypothalamic-pituitary-adrenal axis and unambiguously inhibited pulsatile LH secretion. We next used this paradigm to test the hypothesis that cortisol, acting via the type II glucocorticoid receptor (GR), mediates stress-induced suppression of pulsatile LH secretion. Our approach was to

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Milcarek, Christine. "Linking Endoplasmic Reticular Stress, ELL2, and Alternative Splicing." Journal of Immunology 202, no. 1_Supplement (2019): 123.9. http://dx.doi.org/10.4049/jimmunol.202.supp.123.9.

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Abstract RNA splicing patterns in antibody-secreting cells are shaped by endoplasmic reticulum stress, ELL2 transcription elongation factor induction, and changes in the levels of snRNAs. Endoplasmic reticulum stress induces the unfolded protein response; among these stress proteins is Ire1, whose auto-phosphorylation drives it to acquire a regulated mRNA decay activity. The mRNA-modifying function of phosphorylated Ire1 non-canonically splices Xbp1 and yet degrades other cellular mRNAs with related motifs, in a cell-specific manner. Naïve splenic B cells will activate Ire1 phosphorylation ear

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Xia, Liheng, and Kun Wang. "Effect of Plant Root Secretions on Soil Microorganisms and Seed Germination." Frontiers in Sustainable Development 4, no. 7 (2024): 6–9. http://dx.doi.org/10.54691/6n55j495.

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Root Exudate (RX) is a general term for a series of complex organic substances that are released by plants through the root system into the inter-root soil as part of their photosynthetic products and their own nutrients under certain soil conditions. Root exudate mainly comes from the accumulation of photosynthesis and the decomposition and absorption of nutrients carried out by plants, accounting for about 5% to 30% of photosynthetic products. Its secretion process to the soil is mainly divided into two ways, the first is through the concentration gradient between the plant root cells and th

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Gai, Yedan, Jinglin Zhang, Chao Wei, Wei Cao, Yan Cui, and Sheng Cui. "miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla." American Journal of Physiology-Cell Physiology 312, no. 5 (2017): C663—C672. http://dx.doi.org/10.1152/ajpcell.00345.2016.

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The adrenal gland is an important endocrine gland in balancing homeostasis and the response to stress by synthesizing and secreting catecholamines (CATs), and it has been confirmed that microRNA-375 (miR-375) is highly expressed in adrenal medulla. However, up to now there are few reports about the functions and related mechanisms in adrenal medulla. The present study was thus designed to study the roles and related mechanisms in rat adrenal medulla. Our results showed that miR-375 was specifically expressed in rat adrenal medulla chromaffin cells, and its expression was downregulated when rat

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Song, Wei, Jun Wang, Yumin Zhang, Tao Ma, and Kunzheng Wang. "Effect of Substance P on Differentiation of Bone Marrow Stromal Stem Cells Under Oxidative Stress." Journal of Biomaterials and Tissue Engineering 11, no. 4 (2021): 772–77. http://dx.doi.org/10.1166/jbt.2021.2577.

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Bone marrow stromal stem cells (BMSCs) can be used to treat bone defects but BMSCs are damaged under oxidative stress. The neuropeptide substance P (SP) involves various cellular activities. However, SP’s role in BMSCs differentiation under oxidative stress is unknown. Rat BMSCs were isolated and assigned into control group; oxidative stress group treated with 200 μM H2O2; and SP group, in which 10 mM SP was added under oxidative stress followed by analysis of SP secretion by ELISA, cell proliferation by MTT method, Caspase3 activity, Bax and Bcl-2 level by Real time PCR, ALP activity ROS and

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Meyer, Bianca A., and Shirin Doroudgar. "ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart." Cells 9, no. 9 (2020): 2066. http://dx.doi.org/10.3390/cells9092066.

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Endoplasmic reticulum (ER) stress is a result of conditions that imbalance protein homeostasis or proteostasis at the ER, for example ischemia, and is a common event in various human pathologies, including the diseased heart. Cardiac integrity and function depend on the active secretion of mature proteins from a variety of cell types in the heart, a process that requires an intact ER environment for efficient protein folding and trafficking to the secretory pathway. As a consequence of ER stress, most protein secretion by the ER secretory pathway is decreased. Strikingly, there is a select gro

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Wu, Danhai, and Kan Wang. "Interleukin-15 Regulates Osteogenic/Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Under Oxidative Stress by Regulating PI3K/Akt/mTOR Signaling Pathway." Journal of Biomaterials and Tissue Engineering 9, no. 12 (2019): 1770–75. http://dx.doi.org/10.1166/jbt.2019.2207.

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The oxidative stress process can affect bone marrow mesenchymal stem cells (BMSCs) differentiation. Interleukin (IL-15) regulates fat differentiation of BMSCs. However, the role of IL-15 in osteogenic/adipogenic differentiation of BMSCs under oxidative stress remains unclear. Rat BMSCs were cultured and randomly divided into control group; oxidative stress group and IL-15 treatment group followed by analysis of IL-15 secretion by ELISA, expression of osteocalcin, type I collagen, RUNX2 and OPN mRNA as well as FABP4 and PPARγ 2 by Real time PCR, ALP activity, ROS content and SOD activity, and e

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Brown, L. A. "Glutathione protects signal transduction in type II cells under oxidant stress." American Journal of Physiology-Lung Cellular and Molecular Physiology 266, no. 2 (1994): L172—L177. http://dx.doi.org/10.1152/ajplung.1994.266.2.l172.

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Brief exposure of type II cells to 100 microM t-butyl hydroperoxide (tBOOH) inhibits agonist-induced surfactant secretion and second messenger generation presumably through the oxidation of membrane lipids. Since glutathione (GSH) reduces lipid peroxides and protects type II cells from oxidant injury as determined by crude indicators, then GSH should also protect signal transduction. In the current study, tBOOH inhibited ATP-induced adenosine 3',5'-cyclic monophosphate and inositol trisphosphate generation and surfactant secretion. Stimulation of surfactant secretion by forskolin or phorbol ac

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Nishizawa, Toshihiro, Hidekazu Suzuki, Tatsuhiro Masaoka, et al. "Emotional Stress Enhanced Ghrelin Secretion from the Stomach." Journal of Clinical Biochemistry and Nutrition 38, no. 1 (2006): 33–37. http://dx.doi.org/10.3164/jcbn.38.33.

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Saito, T., H. Itoh, T. Chun, et al. "Oxidative Stress Suppresses the Endothelial Secretion of Endothelin." Journal of Cardiovascular Pharmacology 31 (1998): S345—S347. http://dx.doi.org/10.1097/00005344-199800001-00096.

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Levine, S. P., B. L. Towell, A. M. Suarez, L. K. Knieriem, M. M. Harris, and J. N. George. "Platelet activation and secretion associated with emotional stress." Circulation 71, no. 6 (1985): 1129–34. http://dx.doi.org/10.1161/01.cir.71.6.1129.

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Gibbs, Daniel M. "Stress-Specific Modulation of ACTH Secretion by Oxytocin." Neuroendocrinology 42, no. 6 (1986): 456–58. http://dx.doi.org/10.1159/000124487.

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Aguilera, Greti. "Regulation of Pituitary ACTH Secretion during Chronic Stress." Frontiers in Neuroendocrinology 15, no. 4 (1994): 321–50. http://dx.doi.org/10.1006/frne.1994.1013.

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Lortz, S., S. Lenzen та I. Mehmeti. "Impact of scavenging hydrogen peroxide in the endoplasmic reticulum for β cell function". Journal of Molecular Endocrinology 55, № 1 (2015): 21–29. http://dx.doi.org/10.1530/jme-15-0132.

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Oxidative folding of nascent proteins in the endoplasmic reticulum (ER), catalysed by one or more members of the protein disulfide isomerase family and the sulfhydryl oxidase ER oxidoreductin 1 (ERO1), is accompanied by generation of hydrogen peroxide (H2O2). Because of the high rate of insulin biosynthesis and the low expression of H2O2-inactivating enzymes in pancreatic β cells, it has been proposed that the luminal H2O2concentration might be very high. As the role of this H2O2in ER stress and proinsulin processing is still unsolved, an ER-targeted and luminal-active catalase variant, ER-Cat

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Osterlund, Chad D., Mariana Rodriguez-Santiago, Elizabeth R. Woodruff, Ryan J. Newsom, Anjali P. Chadayammuri, and Robert L. Spencer. "Glucocorticoid Fast Feedback Inhibition of Stress-Induced ACTH Secretion in the Male Rat: Rate Independence and Stress-State Resistance." Endocrinology 157, no. 7 (2016): 2785–98. http://dx.doi.org/10.1210/en.2016-1123.

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Normal glucocorticoid secretion is critical for physiological and mental health. Glucocorticoid secretion is dynamically regulated by glucocorticoid-negative feedback; however, the mechanisms of that feedback process are poorly understood. We assessed the temporal characteristics of glucocorticoid-negative feedback in vivo using a procedure for drug infusions and serial blood collection in unanesthetized rats that produced a minimal disruption of basal ACTH plasma levels. We compared the negative feedback effectiveness present when stress onset coincides with corticosterone's (CORT) rapidly ri

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Darmon, Elise, David Noone, Anne Masson, et al. "A Novel Class of Heat and Secretion Stress-Responsive Genes Is Controlled by the Autoregulated CssRS Two-Component System of Bacillus subtilis." Journal of Bacteriology 184, no. 20 (2002): 5661–71. http://dx.doi.org/10.1128/jb.184.20.5661-5671.2002.

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ABSTRACT Bacteria need dedicated systems that allow appropriate adaptation to the perpetual changes in their environments. In Bacillus subtilis, two HtrA-like proteases, HtrA and HtrB, play critical roles in the cellular response to secretion and heat stresses. Transcription of these genes is induced by the high-level production of a secreted protein or by a temperature upshift. The CssR-CssS two-component regulatory system plays an essential role in this transcriptional activation. Transcription of the cssRS operon is autoregulated and can be induced by secretion stress, by the absence of eit

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