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Journal articles on the topic 'Self-emulsifying drug delivery systems'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Блынская, E. Blynskaya, Турчинская, et al. "The Technology of Self-Emulsifying Drug Delivery Systems." Journal of New Medical Technologies 21, no. 1 (2014): 128–33. http://dx.doi.org/10.12737/3320.

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Nearly 40% of novel chemical entities show evidence of low solubility in water and low bioavailability. Self-emulsifying formulations have showed the power to improve the bioavailability of hydrophobic drugs. Self-emulsifying formulations belong to lipid formulations, and their size range from 100 nm in case of self-emulsifying drug delivery systems and less than 50 nm in case of self-microemulsifying drug delivery systems. In general self-emulsifying formulations s represent isotropic mixtures of oils, surfactants and co-surfactants, which emulsify spontaneous in aqueous media under condition

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Kadian, Renu, and Arun Nanda. "A Comprehensive Insight on Self Emulsifying Drug Delivery Systems." Recent Advances in Drug Delivery and Formulation 16, no. 1 (2022): 15–43. http://dx.doi.org/10.2174/2667387815666211207112803.

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Background: The oral route is a highly recommended route for the delivery of a drug. But most lipophilic drugs are difficult to deliver via this route due to their low aqueous solubility. Selfemulsifying drug delivery systems (SEDDS) have emerged as a potential approach of increasing dissolution of a hydrophobic drug due to spontaneous dispersion in micron or nano sized globules in the GI tract under mild agitation. Objective: The main motive of this review article is to describe the mechanisms, advantages, disadvantages, factors affecting, effects of excipients, possible mechanisms of enhanci

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3

N., Likitha, and Sandeep K. "Self Emulsifying Drug Delivery System." International Journal of Innovative Science and Research Technology 7, no. 11 (2022): 33–40. https://doi.org/10.5281/zenodo.7319153.

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Self-emulsifying drug delivery systems (SEEDS) are mixtures of perfect isotropic oils and surfactants, with or without cosolvents, that emulsify when gently agitated, similar to the conditions found in the gastrointestinal tract. These systems cause the gastro-intestinal tract (GIT) to mildly agitate while forming fine emulsions (or micro-emulsions). The oral absorption of drugs from SEEDS is greatly influenced by a number of factors, including surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size, and charge. This formulation improves bioavailability by increa

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Hamzah, Mohammed Layth, Hanan J. Kassab, and Laith Hamza Samein. "Self-Nano Emulsifying Drug Delivery Systems." Journal of medical pharmaceutical and allied sciences 11, no. 1 (2022): 4205–13. http://dx.doi.org/10.55522/jmpas.v11i1.1388.

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Lipid-based medication conveyance frameworks are widely announced in the writing for improving medication solvency, penetrability, and bioavailability. These frameworks incorporate straightforward oil arrangements, coarse, numerous, and dry emulsions, complex self-emulsifying, miniature emulsifying, or nano emulsifying drug conveyance frameworks. Self-emulsifying frameworks, further named self-miniature emulsifying drug conveyance frameworks (SMEDDS) and self-nano emulsifying drug conveyance frameworks (SNEDDS), are the most overall and economically feasible oil-based methodology for drugs tha

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Reza, Jamilur. "Self-Emulsifying Drug Delivery Systems: A Review." International Journal of Pharmaceutical and Life Sciences 2, no. 2 (2013): 80–84. http://dx.doi.org/10.3329/ijpls.v2i2.15453.

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Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble or lipophilic drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro- or nanoemulsions containing the solubilized drug. Owing to its miniscule globule size, the micro/nanoemulsified drug can easily be absorbed through lymphatic pathways, bypassing the hepatic first-pass effect. But it has drawbacks as formulation development, quality control, stability etc. These liquid SEDDS can be converted into

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6

Deepshikha, Kukde, and Bharkatiya Meenakshi. "Self-emulsifying Drug Delivery System: An Overview with Novel Perspective." Pharmaceutical and Chemical Journal 9, no. 2 (2022): 77–89. https://doi.org/10.5281/zenodo.13970481.

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Self-emulsifying drug delivery systems, which are isotropic mixtures of oils, surfactants, solvents, and co-solvents or surfactants, may be used to design formulations to boost oral absorption of highly lipophilic drug compounds. It may be orally administered in soft or hard gelatin capsules. These systems form fine emulsions or micro-emulsions in the gastro-intestinal tract with mild agitation provided by gastric mobility. These formulations were increased bioavailability due to increasing the solubility of the drug and minimize gastric irritation. The very fact is that almost 40% of the new

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7

Gupta, Shweta, Rajesh Kesarla, and Abdelwahab Omri. "Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems." ISRN Pharmaceutics 2013 (December 26, 2013): 1–16. http://dx.doi.org/10.1155/2013/848043.

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Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media and/or have very low permeability to allow for their adequate and reproducible absorption from the gastrointestinal tract (GIT) following oral administration. Formulation scientists have to adopt various strategies to enhance their absorption. Lipidic formulations are found to be a promising approach to combat the challenges. In this review article, potential advantages and drawbacks of various conventional technique

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8

Reddy, Sunitha M., and Sravani Baskarla. "A Review on Formulation and Development of Solid Self-Nano Emulsifying Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 4 (2021): 5519–228. http://dx.doi.org/10.37285/ijpsn.2021.14.4.1.

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This article describes current strategies to enhance aqueous solubility and dissolution rate of poor soluble drugs. Most drugs in the market are lipophilic with low or poor water solubility. There are various methods to enhance solubility: co-solvency, particle size reduction, salt formation and Self Nanoemulsifying drug delivery systems, SEDDS is a novel approach to enhance solubility, dissolution rate and bioavailability of drugs. The study involves formulation and evaluation of solid self-Nano emulsifying drug delivery system (S-SNEDDS) to enhance aqueous solubility and dissolution rate. Or

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9

Pouton, Colin W. "Formulation of self-emulsifying drug delivery systems." Advanced Drug Delivery Reviews 25, no. 1 (1997): 47–58. http://dx.doi.org/10.1016/s0169-409x(96)00490-5.

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10

Raut, Sayali, Firoj Tamboli, Harinath More, Aishwarya Kulkarni, and Nitin Kokare. "Self-emulsifying drug delivery systems: An overview." International Journal of Pharmacy and Pharmaceutical Science 3, no. 1 (2021): 05–08. http://dx.doi.org/10.33545/26647222.2021.v3.i1a.16.

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11

Yan, Beibei, Yu Gu, Juan Zhao, Yangyang Liu, Lulu Wang, and Yancai Wang. "Self-microemulsion Technology for Water-insoluble Drug Delivery." Current Nanoscience 15, no. 6 (2019): 576–88. http://dx.doi.org/10.2174/1573413715666190112122107.

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: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability

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12

Salawi, Ahmad. "Self-emulsifying drug delivery systems: a novel approach to deliver drugs." Drug Delivery 29, no. 1 (2022): 1811–23. http://dx.doi.org/10.1080/10717544.2022.2083724.

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Salawi, Ahmad. "Self-emulsifying drug delivery systems: a novel approach to deliver drugs." Drug Delivery 29, no. 1 (2022): 1811–23. http://dx.doi.org/10.1080/10717544.2022.2083724.

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14

L., Ramanamma *. Suvendu Kumar Sahoo Sharmila Dusi D.S.V.S. Prasad. "FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR BCS CLASS – II DRUGS USING TRIMETHOPRIM AS A MODEL DRUG." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6733–54. https://doi.org/10.5281/zenodo.1319748.

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<em>Oral route is the easiest and most convenient route for drug administration. Oral drug delivery systems being the most cost-effective and leads the worldwide drug delivery market. The major problem in or it get solubility and then absorbedoral route is a problematic route for those drug molecules which exhibit poor aqueous solubility. When a drug is administrered by oral route the first step for it to get solubilized and then absorbed . formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter- and intra subject variabil

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15

Agubata, Chukwuma. "Self-Emulsifying Formulations: A Pharmaceutical Review." Journal of Drug Delivery and Therapeutics 10, no. 3 (2020): 231–40. http://dx.doi.org/10.22270/jddt.v10i3.3981.

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The oral route of drug delivery is commonly utilized for administration of medicines and is particularly preferred for the treatment of many chronic diseases which require continuous ingestion over a reasonably prolonged period of time. However the oral delivery of lipophilic drugs presents a major obstacle because of their low aqueous solubility. The aqueous solubility of a drug is a crucial determinant of its dissolution rate, absorption and bioavailability. Drugs with relatively high intrinsic lipophilicity can be dissolved in appropriate mixtures of oils/lipids, surfactants, cosolvents whi

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Mohanty, Smitapadma. "Self-micro emulsifying drug delivery systems: State-of-art a technology to enhance the solubility of poorly water-soluble drug." Journal of medical pharmaceutical and allied sciences 11, no. 6 (2022): 5368–74. http://dx.doi.org/10.55522/jmpas.v11i6.4162.

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As new technologies are invented, research in the discovery of new active pharmaceutical moieties is reverberating now a day. Drug solubility is an extensive challenge for formulation scientists as approximately 35-40% of newly discovered drugs show lipophilicity. Low solubility is a rate limiting step for drug dissolution and extends of drug absorption to the systemic circulation. Poor dissolution results in low bioavailability, leading to difficulty to achieve desired therapeutic effect. Drug solubility can be increased by different methods like micronization, solid dispersion, salt formatio

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Leonaviciute, Gintare, and Andreas Bernkop-Schnürch. "Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery." Expert Opinion on Drug Delivery 12, no. 11 (2015): 1703–16. http://dx.doi.org/10.1517/17425247.2015.1068287.

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18

van Staden, Daniélle, Richard K. Haynes, and Joe M. Viljoen. "The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success." Pharmaceuticals 16, no. 10 (2023): 1348. http://dx.doi.org/10.3390/ph16101348.

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Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that are superior to other lipid-based oral drug delivery systems in terms of providing drug protection against the gastrointestinal (GI) environment, inhibition of drug efflux as mediated by P-glycoprotein, enhanced lymphatic drug uptake, improved control over plasma concentration profiles of drugs, enhanced stability, and drug loading efficiency. Interest in dermal spontaneous emulsions has increased, given that systems have been reported to deliver drugs across mucus membranes, as well as the outermost layer of the skin

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19

Kaveri, Karpe1* Ashwini Rathod2 Vrushali Pawar3 Sabafarin Shaikh4 Sneha Patekar5 Dr. Sarita Pawar6. "Advancements and Future Directions in Nano-Enabled Drug Delivery Systems." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2539–50. https://doi.org/10.5281/zenodo.15428844.

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The collection of methods used to deliver a medication or pharmacologically active chemical to the target cell in order to treat a disease or other health concern is known as drug delivery. Oral, buccal, rectal, subcutaneous, intranasal, intramuscular, intravenous, pulmonary, and transdermal are the traditional drug delivery methods. These are widely used techniques to treat a variety of medical issues, but they have drawbacks, including sluggish absorption, enzymatic degradation, instability, uncontrolled release, risk of displacement, and discomfort and irritation as side effects, among many

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20

Akshay, Jadhav* Dr. Ravi Wanare Aniket Kadam Rehan Beniwale Ankita Tayade. "Advances in Self-Emulsifying Drug Delivery Systems: Focus on Pellet-Based Formulations." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2033–46. https://doi.org/10.5281/zenodo.15231553.

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Self-emulsifying drug delivery systems (SEDDS) have emerged as a promising approach to enhance the solubility and oral bioavailability of poorly water-soluble drugs. Among these, self-emulsifying pellets represent a novel solid dosage form that combines the advantages of both SEDDS and multiparticulate systems. This review focuses on the formulation, evaluation, and optimization of self-emulsifying pellets, with particular attention to their application for delivering Venlafaxine Hydrochloride, a BCS Class I drug with high solubility and permeability. Key formulation components, including oils

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21

Dash, Tapaswi Rani* Sharma Pankaj Sharma Sawati Sood Parul. "NOVEL SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) FOR ORAL DELIVERY OF LIPOPHILIC DRUGS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7361–68. https://doi.org/10.5281/zenodo.1006753.

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The self-nanoemulsifying drug delivery system (SNEDDS), is a promising Drug Delivery System which is well known for its prospective to improve the aqueous solubility and oral absorption of poorly water soluble drugs (Pouton, 2000). SNEDDS is an isotropic mixture comprising oil, surfactant, co-surfactant and drug that form oil in water emulsion in aqueous environment under placid agitation. It can readily disperse in the aqueous environment of the gastrointestinal tract to form a fine oil-in-water emulsion with a droplet size not exceeding 100 nm under mild agitation for improving the oral bioa

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22

Deshmukh, Amol S. "Recent Advances in Self-Emulsifying Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 1 (2015): 2693–97. http://dx.doi.org/10.37285/ijpsn.2015.8.1.1.

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Oral route has always been preferred route for formulators and has dominated over other routes of administrations. But major problem encountered in oral formulations (as estimated more than 50 % of oral formulations are found to be poorly aqueous soluble), is low bioavailability, giving rise to further problems like, high inter and intra subject variability, lack of dose uniformity and finally leading to therapeutic failure. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailabili

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23

Rohrer, Julia, Alexandra Partenhauser, Sabine Hauptstein, et al. "Mucus permeating thiolated self-emulsifying drug delivery systems." European Journal of Pharmaceutics and Biopharmaceutics 98 (January 2016): 90–97. http://dx.doi.org/10.1016/j.ejpb.2015.11.004.

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24

Sudheer, Preethi, Koushik Y, Satish P, Uma Shankar M S, and R. S. Thakur. "Development of Solid-Self Micron Emulsifying Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 2 (2013): 2014–21. http://dx.doi.org/10.37285/ijpsn.2013.6.2.2.

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As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble and solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation for therapeutic response. It is a great challenge for pharmaceutical scientist to convert those molecules into orally administered formulation with sufficient bioavailability. Among the several approaches to improve oral bioavailability of these molecules, Self-micron emulsifying drug delivery sy

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25

Park, Heejun, Eun-Sol Ha, and Min-Soo Kim. "Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems." Pharmaceutics 12, no. 4 (2020): 365. http://dx.doi.org/10.3390/pharmaceutics12040365.

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Self-emulsifying drug delivery systems (SEDDSs) are a vital strategy to enhance the bioavailability (BA) of formulations of poorly water-soluble compounds. However, these formulations have certain limitations, including in vivo drug precipitation, poor in vitro in vivo correlation due to a lack of predictive in vitro tests, issues in handling of liquid formulation, and physico-chemical instability of drug and/or vehicle components. To overcome these limitations, which restrict the potential usage of such systems, the supersaturable SEDDSs (su-SEDDSs) have gained attention based on the fact tha

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Nisha, Limboo* Divya Pradhan. "Poor Aqueous Soluble Drugs; Challenges and Solution to Overcome with Self-Emulsification Systems: A Systemic Review." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 691–711. https://doi.org/10.5281/zenodo.15165250.

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Fat-based treatment delivery systems have shown great potential in considering the delivery of moderately soluble drugs only. The limited solubility of these molecules in water makes oral lipid-loving medications very difficult. Since, when it comes to oral administration of slightly water-soluble drugs, methods of delivery of fat-based drugs have shown an excessive amount of potential. The solubility phase, which may be a problem that limits the oral absorption rate of insufficiently soluble drugs in water, is eliminated when the drugs are pre-dissolved in oils, surfactants, lipid mixtures an

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27

M., Udaya Sakthi, Josephine Ritashinita Lobo F., and Kiran B. Uppuluri. "Self Nano Emulsifying Drug Delivery Systems for Oral Delivery of Hydrophobic Drugs." Biomedical & Pharmacology Journal 6, no. 2 (2013): 355–62. http://dx.doi.org/10.13005/bpj/425.

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M, Mounika, Kumar Desu Prasanna, and Vanitha K. "A Review on Self Nano Emulsifying Drug Delivery System." Trends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457) 2, no. 1 (2019): 12–23. https://doi.org/10.5281/zenodo.3579794.

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<em>A self-nano emulsifying drug delivery system (SNEDDS) is a scheme of drug delivery that utilizes a chemical rather than a mechanical method of Nano emulsion . That is, by an intrinsic property of the drug formulation. It utilizes the familiar ouzo impact shown by anethole in many anise-flavored liquors, rather than by unique blending and handling Nano emulsion s have significant potential for use in the delivery of drugs, and SNEDDS (including so-called "U-type" nano emulsions) is the best of those systems to date identified. SNEDDS are of particular value in increasing the absor

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van Staden, Daniélle, Richard K. Haynes, and Joe M. Viljoen. "The Science of Selecting Excipients for Dermal Self-Emulsifying Drug Delivery Systems." Pharmaceutics 15, no. 4 (2023): 1293. http://dx.doi.org/10.3390/pharmaceutics15041293.

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Self-emulsification is considered a formulation technique that has proven capacity to improve oral drug delivery of poorly soluble drugs by advancing both solubility and bioavailability. The capacity of these formulations to produce emulsions after moderate agitation and dilution by means of water phase addition provides a simplified method to improve delivery of lipophilic drugs, where prolonged drug dissolution in the aqueous environment of the gastro-intestinal (GI) tract is known as the rate-limiting step rendering decreased drug absorption. Additionally, spontaneous emulsification has bee

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Wankhade, Vikrant P., Nivedita S. Kale, and K. K. Tapar. "Self Microemulsifying Nutraceutical and Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 3 (2014): 2520–28. http://dx.doi.org/10.37285/ijpsn.2014.7.3.3.

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Many chemical entities and nutraceuticals are poor water soluble and show high lipophilicity. It’s difficult to formulate them into oral formulation because of its low aqueous solubility which ultimately affects bioavailability. To enhance the bioavailability of such drugs compounds, self microemulsifying drug delivery system is the reliable drug delivery system. In this system the drug is incorporated in the isotropic system and formulated as unit dosage form. Self microemulsifying drug delivery system is the novel emulsified system composed of anhydrous isotropic mixture of oils, surfactant,

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31

Singh, Bhupinder, Sarwar Beg, Rajneet Kaur Khurana, Premjeet Singh Sandhu, Ravinder Kaur, and Om Parkash Katare. "Recent Advances in Self-Emulsifying Drug Delivery Systems (SEDDS)." Critical Reviews in Therapeutic Drug Carrier Systems 31, no. 2 (2014): 121–85. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.2014008502.

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32

Ujhelyi, Zoltán, Miklós Vecsernyés, Pálma Fehér, et al. "Physico-chemical characterization of self-emulsifying drug delivery systems." Drug Discovery Today: Technologies 27 (July 2018): 81–86. http://dx.doi.org/10.1016/j.ddtec.2018.06.005.

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Bodnar, Liubov, Nataliia Polovko, Nataliia Bevz, Volodymyr Hrudko, and Olesia Perepelytsia. "Biopharmaceutical justification of the creation of self-emulsifying drug delivery systems with simvastatin." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 4–10. http://dx.doi.org/10.15587/2519-4852.2023.277351.

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The aim of the research – to conduct biopharmaceutical tests of capsules with a self-emulsifying delivery system of simvastatin to confirm the effectiveness and feasibility of introducing into the composition of self-emulsifying drug delivery systems active pharmaceutical ingredients that are difficult to dissolve in the gastric juice environment. Material and methods. Substances, excipients, reagents and materials used during research were simvastatin (India, p. DK40-2005021, 99.09 %), castor oil (Ukraine), polyethylene glycol 40 hydrogenated castor oil (India), Tween 80 (Ukraine), glyc

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Liubov, Bodnar, Polovko Nataliia, Bevz Nataliia, Hrudko Volodymyr, and Perepelytsia Olesia. "Biopharmaceutical justification of the creation of self-emulsifying drug delivery systems with simvastatin." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 4–10. https://doi.org/10.15587/2519-4852.2023.277351.

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<strong>The aim of the research </strong>– to conduct biopharmaceutical tests of capsules with a self-emulsifying delivery system of simvastatin to confirm the effectiveness and feasibility of introducing into the composition of self-emulsifying drug delivery systems active pharmaceutical ingredients that are difficult to dissolve in the gastric juice environment. <strong>Material and methods. </strong>Substances, excipients, reagents and materials used during research were simvastatin (India, p. DK40-2005021, 99.09 %), castor oil (Ukraine), polyethylene glycol 40 hydrogenated

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Neslihan Gursoy, R., and Simon Benita. "Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs." Biomedicine & Pharmacotherapy 58, no. 3 (2004): 173–82. http://dx.doi.org/10.1016/j.biopha.2004.02.001.

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Doke, Vishakha Vishwanath, Nilesh M. Khutle, Maya Sharma, and Khemchand Gupta. "Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug Delivery System." Indian Journal Of Science And Technology 15, no. 30 (2022): 1504–16. http://dx.doi.org/10.17485/ijst/v15i30.582.

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Yadav, Ankita, Moreshwar Patil, Shrenik Tated, et al. "SELF EMULSIFYING DRUG DELIVERY SYSTEMS: AN APPROACH TO MODIFY DRUG PERFORMANCE." International Journal of Innovative and Applied Research 12, no. 4 (2024): 1–11. http://dx.doi.org/10.58538/ijiar/2096.

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Pouton, Colin W. "Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems." European Journal of Pharmaceutical Sciences 11 (October 2000): S93—S98. http://dx.doi.org/10.1016/s0928-0987(00)00167-6.

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Ronak, Kumar Rabadiya*1 Divya Gupta2 Chainesh Shah3 Umesh Upadhyay4. "Nanoemulsions: A Promising Technology For The Development Of Innovative Products." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 709–19. https://doi.org/10.5281/zenodo.13759881.

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Nanoemulsions are submicron-sized emulsions under extensive investigation as drug carriers for improving the delivery of therapeutic agents. They are the most advanced nanoparticle systems for the systemic delivery of biologically active agents for controlled drug delivery and targeting. Nanoemulsions are thermodynamically stable isotropic systems formed by mixing two immiscible liquids (water and oil) with suitable surfactants or their mixture to obtain a single phase with a droplet diameter ranging from 0.5 to 100 um. The size distributions of nanoemulsion droplets are narrow and usually lie

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40

Harsh, Pathak, Pande Sonal, Jiwani Munaf, Ankalge Rajesh, and Rohit Mehul. "Pharmaceutical Aspects of Self Emulsifying Drug Delivery System: A Comprehensive Review." Recent Trends in Pharmaceutical Sciences and Research 2, no. 1 (2019): 19–44. https://doi.org/10.5281/zenodo.3474625.

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<em>Low aqueous solubility of the newly discovered drug possesses a great challenge for the development of dosage form with suitable applicability. Self-Emulsifying Drug Delivery System (SEDDS) provides an excellent alternative for increasing solubility of lipid soluble drugs which is achieved by microemulsion through chemical means. </em><em>Self-Emulsifying drug delivery system is the blend of surfactants and oils which are isotropic in nature. It also includes co-solvents which upon gentle agitation gets emulsified under conditions mimicking to those which would be encountered in the gastro

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Sharma, Vijay K., Aishwarya Koka, Jyoti Yadav, Anil K. Sharma, and Raj K. Keservani. "Self-Micro Emulsifying Drug Delivery Systems: A Strategy to Improve Oral Bioavailability." Ars Pharmaceutica (Internet) 57, no. 3 (2016): 97–109. http://dx.doi.org/10.30827/ars.v57i3.5327.

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Aim: Oral route has always been the favorite route of drug administration in many diseases and till today it is the first way investigated in the development of new dosage forms. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility, thereby pose problems in their formulation. For the therapeutic delivery of lipophilic active moieties (BCS class II drugs), lipid based formulations are inviting increasing attention. Methods: To that aim, from the web sites of PubMed, HCAplus, Thomson, and Registry were used as the main

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Yadav, Sachin Kumar, Nayyar Parvez, and Pramod Kumar Sharma. "An insight to self emulsifying drug delivery systems, their applications and importance in novel drug delivery." Journal of Scientific and Innovative Research 3, no. 2 (2014): 273–81. http://dx.doi.org/10.31254/jsir.2014.3225.

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Since last couple of years Self-emulsifying drug delivery systems are becoming important tool in novel drug delivery. It is very useful in solving problems such as low bioavailability issues associated with poorly water soluble drugs. The bioavailability of lipophilic drugs (BCS-II and IV) can be enhanced by these systems. SEDDS is released in the lumen of the gastrointestinal tract (GIT) after administration and with the aid of GI fluid a fine emulsion (micro-/nanoemulsion) is formed. The increased surface area and amphoteric nature of SEDDS lead to increase in bioavailability. The hepatic fi

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Kanuganti, Swetha, Raju Jukanti, Prabhakar R. Veerareddy, and Suresh Bandari. "Paliperidone-Loaded Self-Emulsifying Drug Delivery Systems (SEDDS) for Improved Oral Delivery." Journal of Dispersion Science and Technology 33, no. 4 (2012): 506–15. http://dx.doi.org/10.1080/01932691.2011.574920.

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Gavrilov, D. I., S. V. Tishkov, E. V. Blynskaya, K. V. Alekseev, S. V. Minaev, and D. M. Abramova. "Excipients used for the creation of self-emulsifying drug delivery systems." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology, no. 1 (February 25, 2023): 25–32. http://dx.doi.org/10.33920/med-13-2301-02.

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This review provides a classification of excipients that are used in the creation of self-emulsifying drug delivery systems (SEDDS). The criteria for their selection and their characteristics are also described.

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Tang, Jing-ling, Jin Sun, and Zhong-Gui He. "Self-Emulsifying Drug Delivery Systems: Strategy for Improving Oral Delivery of Poorly Soluble Drugs." Current Drug Therapy 2, no. 1 (2007): 85–93. http://dx.doi.org/10.2174/157488507779422400.

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van Staden, Daniélle, Jeanetta du Plessis, and Joe Viljoen. "Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected." Scientia Pharmaceutica 88, no. 2 (2020): 17. http://dx.doi.org/10.3390/scipharm88020017.

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Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery possibilities presented by these uniquely simplified systems in terms of muco-adhesiveness and zeta-potential changing capacity lead the way forward to ground-breaking research. Contrarily, SEDDSs destined for topical/transdermal drug delivery have received limited attention. Therefore, this review is focused at utilising principles, established during development of oral SEDDSs, a

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Singh, Balwan, and Manish Sharma. "0Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems for Candesartan Cilexetil." International Journal of Pharmaceutical Sciences and Nanotechnology 15, no. 2 (2022): 5844–54. http://dx.doi.org/10.37285/ijpsn.2022.15.2.3.

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Introduction: Candesartan cilexetil is an angiotensin receptor blocker prescribed for hypertension management. However the drug belonging to BCS class II has low solubility and in turn low bioavailability. Lipid-based drug delivery systems are gaining wide attention in the field of pharmaceutical formulations owing to their potential to enhance the solubility of poorly aqueous soluble drugs. Objective: “Present” work aimed to formulate and evaluate Candesartan cilexetil loaded Self-emulsifying drug delivery systems (SEDDS) as a potential antihypertensive drug delivery system by improving

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B, Medha Gayatri, and Vasanthi A. V. "SNEDDS- A New Frontier in Oral Drug Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 18, no. 1 (2025): 7895. https://doi.org/10.37285/ijpsn.2025.18.1.16.

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Self-Nano-Emulsifying Drug-Delivery Systems (SNEDDS) are a novel method to increase the oral bioavailability of poorly soluble drugs and are one of the latest in the business today. Such systems are composed of oil, surfactant, and co-surfactant, which can, in the wake of their dilution in aqueous media, instantaneously produce the nano emulsions. The small-scale dispersion of the drug in the system leads to its solubilization and absorption, which in turn results in better therapeutic efficacy.

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R, Panner Selvam, Kulkarni P. K, and Naga Sravan Kumar Varma V. "Porous polystyrene spheres loaded self nano-emulsifying systems of rosuvastatin calcium." RSC Advances 5, no. 85 (2015): 69642–50. http://dx.doi.org/10.1039/c5ra12045d.

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Lee, You Zhuan, Eng Kwong Seow, Sheau Chin Lim, Kah Hay Yuen, and Nurzalina Abdul Karim Khan. "Formulation and In Vivo Evaluation of a Solid Self-Emulsifying Drug Delivery System Using Oily Liquid Tocotrienols as Model Active Substance." Pharmaceutics 13, no. 11 (2021): 1777. http://dx.doi.org/10.3390/pharmaceutics13111777.

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Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of poorly water-soluble drugs. Solid self-emulsifying drug delivery systems (s-SEDDS) offer several advantages including improved drug stability, ease of administration, and production. Most compounds employed in developing s-SEDDS are solid in nature, with a high amount of surfactants added. The aim of this study was to develop an s-SEDDS using a tocotrienol-rich fraction (TRF) as the model liquid active substance via a simple adsorption method. The solid formulation was developed using magnesium aluminosilica

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