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Journal articles on the topic 'Selfnano emulsifying drug delivery system (SNEDDS)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Vishakha, Vishwanath Doke, M. Khutle Nilesh, Sharma Maya, and Gupta Khemchand. "Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug Delivery System." Indian Journal of Science and Technology 15, no. 30 (2022): 1504–16. https://doi.org/10.17485/IJST/v15i30.582.

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Abstract <strong>Objectives:</strong> To enhance solubility, dissolution, and permeability of poorly water-soluble drug Ezetimibe (EZE) using a self-nano emulsifying drug delivery system (SNEDDS). <strong>Methods:</strong> Initially, the solubility of the EZE was determined in various oils and buffers. Surfactants and co-surfactants were screened based on the solubility of the drug in oil as per the emulsification efficacy test. Liquid SNEDDS was developed and characterized. Solid SNEDDS was developed and characterized using optimized liquid SNEDDS followed by the development of

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M, Mounika, Kumar Desu Prasanna, and Vanitha K. "A Review on Self Nano Emulsifying Drug Delivery System." Trends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457) 2, no. 1 (2019): 12–23. https://doi.org/10.5281/zenodo.3579794.

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<em>A self-nano emulsifying drug delivery system (SNEDDS) is a scheme of drug delivery that utilizes a chemical rather than a mechanical method of Nano emulsion . That is, by an intrinsic property of the drug formulation. It utilizes the familiar ouzo impact shown by anethole in many anise-flavored liquors, rather than by unique blending and handling Nano emulsion s have significant potential for use in the delivery of drugs, and SNEDDS (including so-called "U-type" nano emulsions) is the best of those systems to date identified. SNEDDS are of particular value in increasing the absor

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Gande, Suresh, S. Srikanth Reddy, and Bhikshapathi D. V. R. N. "Enhancement of Nimodipine Solubility by Self-Nano-emulsifying Drug Delivery System." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 5 (2019): 4648–56. http://dx.doi.org/10.37285/ijpsn.2019.12.5.5.

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Self-nanoemulsifying drug delivery system (SNEDDS) of Nimodipine was developed with the purpose of improving the bioavailability of the drug. Based on the results of Nimodipine solubility studies Peceol, Transcutol P and PEG 400 were optimized as oil, surfactant and co-surfactant for the formulation and Pseudo ternary plots was constructed by Chemix software. Fifteen formulations of Nimodipine SNEDDS prepared and analyzed for particle size, emulsification time, percentage drug release, percentage transmittance, in vitro drug dissolution studies and thermodynamic stability. The optimized Nimodi

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VERMA, ANUPAM, RAJESH ASIJA, and ANIL GOYAL. "SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM: AN UPDATED REVIEW." Tropical Journal of Pharmaceutical and Life Sciences 9, no. 2 (2022): 11–20. https://doi.org/10.61280/tjpls.v9i2.81.

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Self- nano emulsifying drug delivery system (SNEDDS) is getting popularity for enhancing the solubility of hydrophobic drugs. SNEDDS are employed to solve issues regarding low bioavailability of poorly soluble and greatly permeable compounds. The SNEDDS are isotropic mixtures of solvents, co-solvents, surfactants and oil. The chief characteristic of SNEDDS is their capability to make acceptable Microemulsions or oil‐in‐water (o/w) emulsions with mild agitation. SNEDDS comprise a less content of lipid whereas greater amount of lipophobic surfactants and co-surfactants. Usually SNEDDS prepared a

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Vishakha, Vishwanath Doke, M. Khutle Nilesh, Sharma Maya, and Gupta Khemchand. "Self-Solidifying and Self-Nanoemulsifying Drug Delivery System of Itraconazole." Indian Journal of Science and Technology 16, no. 3 (2023): 190–203. https://doi.org/10.17485/IJST/v16i3.1940.

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ABSTRACT <strong>Objective:</strong> To improve solubility, dissolution, and permeability of BCS class II drug Itraconazole (ITZ) using a self solidifying self nano emulsifying drug delivery system (SNEDDS). <strong>Method:</strong> The solubility of ITZ was assessed in oils, surfactants, co-surfactants, and buffers. Surfactants, co-surfactants, and combination of surfactants (S-comb) were selected on the basis of emulsification efficacy test. The ability to solidify self emulsifying mixture was assessed and solid SNEDDSS was developed and optimised. <strong>Finding:</stron

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6

Chandran, Rajinikanth, and Kathiresan Krishnasamy. "Solubility Enhancement of Palbociclib Supersaturable Self-Nano Emulsifying Drug Delivery System by Central Composite Design." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 169–77. http://dx.doi.org/10.25258/ijpqa.15.1.27.

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Nowadays, solid self-nano-emulsifying supersaturable drug delivery systems (S-SNEDDS) are being investigated to overcome the limitations of self-nano-emulsifying drug delivery systems (SNEDDS). The current study established S-SNEDDS for better drug dissolution and stability. S-SNEDDS were made with saturated solubility capryol® 90, labrosol®, and transcutol® HP. The composition was optimized using ternary phase diagrams. Palbociclib-SNEDDS created droplet size (Y1), polydispersity index (PDI) (Y2), and 15-minute drug release (Y3) responses using the central composite design (CCD) of response s

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Dash, Tapaswi Rani* Sharma Pankaj Sharma Sawati Sood Parul. "NOVEL SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) FOR ORAL DELIVERY OF LIPOPHILIC DRUGS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7361–68. https://doi.org/10.5281/zenodo.1006753.

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The self-nanoemulsifying drug delivery system (SNEDDS), is a promising Drug Delivery System which is well known for its prospective to improve the aqueous solubility and oral absorption of poorly water soluble drugs (Pouton, 2000). SNEDDS is an isotropic mixture comprising oil, surfactant, co-surfactant and drug that form oil in water emulsion in aqueous environment under placid agitation. It can readily disperse in the aqueous environment of the gastrointestinal tract to form a fine oil-in-water emulsion with a droplet size not exceeding 100 nm under mild agitation for improving the oral bioa

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8

., Pooja, Pankaj Kumar Sharma, and Viswanath Agrahari. "DESIGN AND EVALUATION OF SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEMS OF ALVERINE FOR ENHANCEMENT OF SOLUBILITY." International Research Journal of Pharmacy 12, no. 7 (2021): 25–31. http://dx.doi.org/10.7897/2230-8407.1207153.

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Background: The aim of this study is to develop a liquid self-nano emulsifying drug delivery system for alverine (liquid-SNEDDS).Excipients in the alverine SNEDDS include Ethyl oleate as the oil phase, Tween 80 as a surfactant, and PEG600, Propylene glycol as a cosurfactant.The prepared eleven formulations of alverine SNEDDS were performed for emulsification time, percentage transmittance, particle size, drug release, in vitro dissolution and stability studies.The optimised alverine liquid SNEDDS formulation (D1) was studied for drug-excipient compatibility using infrared spectroscopy, as well

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Reddy, Sunitha M., and Sravani Baskarla. "A Review on Formulation and Development of Solid Self-Nano Emulsifying Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 4 (2021): 5519–228. http://dx.doi.org/10.37285/ijpsn.2021.14.4.1.

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This article describes current strategies to enhance aqueous solubility and dissolution rate of poor soluble drugs. Most drugs in the market are lipophilic with low or poor water solubility. There are various methods to enhance solubility: co-solvency, particle size reduction, salt formation and Self Nanoemulsifying drug delivery systems, SEDDS is a novel approach to enhance solubility, dissolution rate and bioavailability of drugs. The study involves formulation and evaluation of solid self-Nano emulsifying drug delivery system (S-SNEDDS) to enhance aqueous solubility and dissolution rate. Or

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Fida, Saima, Aamir Jalil, Rukhshanda Habib, et al. "Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery." PLOS ONE 17, no. 3 (2022): e0266296. http://dx.doi.org/10.1371/journal.pone.0266296.

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The major goal of this project was to formulate iodine-based self nano-emulsifying drug delivery system to provide improve antimicrobial activity and enhanced mucosal residence time via mucus penetration. Iodine SNEDDS (Self nano-emulsifying drug delivery system) with different concentration were formulated using castor oil as the oil phase, cremophor ethoxylated (CrEL) as a surfactant and after screening a number of vehicles, PEG 400 was employed as co-surfactant. Self-emulsification time, thermodynamic stability tests, robustness to dilution, percent transmittance, droplet size, and drug rel

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Tayal, Shivam, and Md Mannan Ansari. "Formulation and Evaluation of Self Nano Emulsifying Drug Delivery System Containing Mesalamine." Asian Journal of Applied Science and Technology 09, no. 02 (2025): 86–99. https://doi.org/10.38177/ajast.2025.9209.

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The Self-Nano Emulsifying Drug Delivery System (SNEDDS) represents a modern strategy to improving the oral availability of poorly water-soluble medication. The two main goals of the study were to design and evaluate mesalamine containing S-SNEDDS that would deliver the medicine particularly to the colon, increasing its oral bioavailability, and to investigate the characteristics of biosurfactants as pharmaceutical emulsifiers for L-SNEDDS. The optimal formulations were determined using a pseudo-ternary phase diagram comprising olive oil as the oil phase, biosurfactant as the surfactant, and PE

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Suhery, W. N., Y. C. Sumirtapura, J. S. Pamudji, and D. Mudhakir. "SOLID SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF FENOFIBRIC ACID: PHYSICOCHEMICAL PROPERTIES AND IN VITRO EVALUATION." RASAYAN Journal of Chemistry 15, no. 03 (2022): 1916–21. http://dx.doi.org/10.31788/rjc.2022.1536705.

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Physicochemical properties and dissolution of Fenofibric acid (FA) solid self-nano emulsifying drug delivery system (solid SNEDDS) were investigated. Kollisolv® MCT 70 (medium-chain triglyceride), Kolliphor® RH 40, and Transcutol® HP as the oil, surfactant, and cosurfactant for SNEDDS formulation. The optimized SNEDDS formulation was solidified into solid SNEDDS using porous carriers (Neusilin® US2 and Aerosil 200), with a ratio of 33% and 50% (w/v) respectively (SS1–SS4). The selected solid SNEDDS formulation of FA (SS1) could increase the dissolution of FA 1.75-fold compared to the pure drug

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D, Saritha, Penjuri Subhash Chandra Bose, and Nagaraju Ravoru. "Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System of Naproxen." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 1 (2015): 2715–22. http://dx.doi.org/10.37285/ijpsn.2015.8.1.3.

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 Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro or nanoemulsions containing the solubilized drug. The objective of the present work was to formulate a self nanoemulsifying drug delivery system (SNEDDS) for naproxen. Naproxen SNEDDS were formulated using Labrafac PG (Oil), Span 80 (Surfactant) and propylene glycol (Co surfactant). The developed SNEDDS were evaluated for turbidimetry, d

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14

Arshad, Rabia, Tanveer A. Tabish, Maria Hassan Kiani, et al. "A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection." Nanomaterials 11, no. 5 (2021): 1086. http://dx.doi.org/10.3390/nano11051086.

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Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation. To synergistically improve the biopharmaceutical parameters of CIP, a hyaluronic acid (FDA approved biocompatible polymer) functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) was designed in the present study. SNEDDS formulations were tested via solubility, droplet size, zeta potential, a polydispersity index, thermodynamic stability, surface

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15

Putri, Salsabila Ayundiva, and Lina Winarti. "Meloxicam self-nano-emulsifying drug delivery system with surfactants combination: Formulation and in vitro release model." Pharmacy Education 23, no. 4 (2023): 71–75. http://dx.doi.org/10.46542/pe.2023.234.7175.

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Background: Meloxicam has low water solubility, which affects the dissolution and level of absorption. Objective: The study aimed to develop a self-nano-emulsifying drug delivery system (SNEDDS) based on a non-ionic surfactant combination and evaluate the release kinetics model using the DDsolver program. Methods: Oil, surfactant, and co-surfactant were selected based on the solubility of meloxicam. Results: The best formula showed that 10% of castor oil, 70% of surfactant (tween 80: chromophore RH 40 in 1:1), and 20% of PEG 400 could develop SNEDDS with the 99.84±0.04% percentage of transmitt

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Vishal N Kushare and Saravanan S. "Invitro and invivo evaluation of anticonvulsant herbal drug loaded self nano emulsifying drug delivery system." International Journal of Pharmaceutical Research and Life Sciences 6, no. 2 (2018): 38–44. http://dx.doi.org/10.26452/ijprls.v6i2.1279.

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The aim of present study was to formulate and evaluate emulsifying drug delivery system (SNEDDS) of poorly and herbal drug like () extract, which was extracted from Coriandrum seeds by using ( method extraction process). are isolated by using column chromatography and concentrated under reduced pressure by using rotary flash evaporator., an essential of Coriandrum with anti-epileptic activity.the oil phase like , Tween 80 and PEG-200 were selected as and respectively for the formulation of SNEDDS(9 formulation). all the formulation S9 shows maximum cumulative amount of drug release of about97.

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Sahumena, Muhamad Handoyo, and Suryani Suryani. "Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan." Indonesian Journal of Pharmaceutical Education 2, no. 3 (2023): 239–46. http://dx.doi.org/10.37311/ijpe.v2i3.20405.

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Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and has poor dissolution. The aim of this study was to overcome the solubility of ibuprofen through a stable SNEDDS formula. One way to overcome the solubility of ibuprofen is to prepare nanoemulsions using the Self-Emulsifying Drug Delivery System (SNEDDS) technique. SNEDDS is a form of preemulsion drug which spontaneously forms nanoemulsion when

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18

Mali, Gokul Pandurang. "Formulation and Development of Solid Nano-Emulsifying Drug Delivery System of BCS Class IV Drug Delafloxacin." International Journal for Research in Applied Science and Engineering Technology 13, no. 4 (2025): 5328–39. https://doi.org/10.22214/ijraset.2025.69558.

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Abstract: Aqueous solubility of drugs is one of the most important factors that determine their dissolution performance and hence oral absorption and bioavailability. About 70% of new drug substances are poorly water soluble and exhibit slow dissolution rates and often incomplete oral bioavailability. The aim of present investigation is to develop a novel emulsifying drug delivery system (SNEDDS) to enhance the dissolution rate profile by increasing the solubility of Delafloxacin. The oral route is the most commonly used method for administration of drugs, with nearly 80% of the marketed dosag

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Darna, Bhikshapathi, and Bommareddy Srinivasa Padma Ganesh. "Development and In vivo Evaluation of Pitavastatin Self-emulsifying Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Drug Research 13, no. 03 (2020): 295–302. http://dx.doi.org/10.25004/ijpsdr.2021.130309.

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The current research was intended at formulation and in vivo evaluation of pitavastatin self-nano emulsifying drug delivery system (PTN SNEDDS) for enhanced drug dissolution and bioavailability. Solubility studies carried out to construct pseudoternary phase diagram employing the blends of oil (capmulPG8), surfactant (acrysol K140), and cosurfactant (transcutol P). The PNT SNEDDS was prepared and optimized by adopting response surface methodology employing a 33 Box-Behnken design. The SNEDDS formulations characterized for % drug content, % entrapment efficiency, in-vitro release studies, parti

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Aishwarya, Nara, and Shaik Muhammad Fazal ul Haq. "Formulation and Evaluation of Solid-Self Nano Emulsifying Drug Delivery System of Darunavir." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 558–74. http://dx.doi.org/10.36348/sjmps.2022.v08i10.010.

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The main aim of this research article is to Formulate and Evaluate the S-SNEDDS of Darunavir. Darunavir is an anti-retroviral protease inhibitor which is in use from long time, but it has poor bioavailability because of poor aqueous solubility and extensive first pass metabolism, when used in the form of conventional dosage form. As it is a BCS Class II drug, which shows low solubility and high permeability. The S-SNEDDS of Darunavir was prepared to improve its oral bioavailability and its release rate was evaluated by in vitro release. The solubility of Darunavir in various oils was to decide

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Shrishail M Ghurghure, Priya L. Ingale, Anup A. Dhange, Akshay S Javalgikar, Rudramuni H Kore, and Dadagouda M Birajdar. "Itraconazole Self-Nano Emusifying Drug Delivery System for Enhancement of Solubility." Journal of Advanced Zoology 44, no. 5 (2023): 150–55. http://dx.doi.org/10.17762/jaz.v44i5.2577.

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The main objective of formulation is to enhance the bioavailability of the drug within the body. Some of the challenging subjects associated with poorly water-soluble drugs concern solubility and bioavailability factors. To overcome these problems, new technologies, such as lipid-based drug delivery systems including micro or nano emulsifying drug delivery system, have obtained importance in recent years, due to their enhanced solubility and bioavailability in the gastrointestinal tract. Such systems are solubilized within the lipid excipients or mixed with oils or surfactants/co-solvents to f

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R, Panner Selvam, Kulkarni P. K, and Naga Sravan Kumar Varma V. "Porous polystyrene spheres loaded self nano-emulsifying systems of rosuvastatin calcium." RSC Advances 5, no. 85 (2015): 69642–50. http://dx.doi.org/10.1039/c5ra12045d.

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Issusilaningtyas, Elisa, and Septiana Indratmoko. "Formulasi Self Nano Emulsifying Drug Delivery System (Snedds) Ekstrak Etanol Daun Sukun (Artocarpus Altilis)." Pharmaqueous : Jurnal Ilmiah Kefarmasian 3, no. 1 (2021): 18–25. http://dx.doi.org/10.36760/jp.v3i1.264.

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Ekstrak daun sukun memiliki manfaat dapat digunakan sebagai antidiabetik, antioksidan dan antibakteri. Pengembangan teknologi formulasi diperlukan meningkatkan efektivitas penghantaran obat didalam tubuh sehingga diperoleh efek farmakologi yang baik. Formulasi nanoemulsi dengan teknik SNEDDS diharapkan dapat meningkatkan penghantaran obat didalam tubuh secara maksimal dan meningkatkan transport obat. Tujuan dari penelitian ini untuk mengetahui komposisi optimum formula SNEDDS ekstrak daun sukun berserta pengujian fisik nanoemulsi. Parameter pengujian fisik 14 formula diperoleh formula optimal

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Weerapol, Yotsanan, Sontaya Limmatvapirat, and Pornsak Sriamornsak. "Effect of Lipophilicity of Drugs on Dissolution Profiles of Self-Nanoemulsifying Drug Delivery System." Advanced Materials Research 1060 (December 2014): 37–40. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.37.

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The low solubility of poorly water-soluble drug is a major problem of oral drug adsorption. The self-emulsifying system can be applied to eliminate the drug dissolution step and improve the drug absorption. In this research, liquid self-nanoemulsifying drug delivery system (SNEDDS) composing of polyethoxylated castor oil, caprylic/capric glyceride and diethylene glycol monoethyl ether was developed. The drugs with similar structure but different lipophilicity (log P), nifedipine (NDP), felodipine (FDP) and manidipine (MDP), were investigated. Size and size distribution of emulsion after diluti

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Yudanti, Gendis Purno, Ilham Kuncahyo, and Endang Diyah Ikasari. "Optimization of Naringenin Self-Nano Emulsifying Drug Delivery System (SNEDDS) Formula with D-optimal Mixture Design Method." Journal of Pharmaceutical Sciences and Community 21, no. 1 (2024): 100–108. http://dx.doi.org/10.24071/jpsc.004319.

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This study aimed to optimize and formulate the poorly water-soluble naringenin in the Self-Nano Emulsifying Drug Delivery System (SNEDDS) using D-optimal mixture design. D-optimal mixture design was used to optimize SNEDDS loading naringenin by selecting SNEDDS composition as an independent factor and SNEDDS characterization as a response. SNEDDS in the optimal formula were characterized, including transmittance, particle size, emulsification time, and drug loading. Triacetin, Tween 80, and transcutol p were respectively the selected oil, surfactant, and co-surfactant phases for their greatest

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Yuwanda, Alhara, and Anugerah Budipratama Adina. "Pengembangan Snedds Ekstrak Daun Pepaya (Carica Papaya L.) untuk Meningkatkan Efikasi Anthelmintik dalam Praktik Keperawatan." Malahayati Nursing Journal 7, no. 4 (2025): 1449–62. https://doi.org/10.33024/mnj.v7i4.18934.

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ABSTRACT The development of Self-Nano Emulsifying Drug Delivery System (SNEDDS) aims to enhance drug bioavailability and release effectiveness. SNEDDS utilizes papaya leaf extract as an active ingredient with therapeutic potential. This study aims to evaluate five SNEDDS formulations based on organoleptic parameters, transmittance, particle size, PDI, zeta potential, pH level, and cumulative drug release percentage. Formulations were created using an optimal mixing technique, followed by testing each parameter to determine the characteristics of the formulations. Measurements were taken at dif

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Gohel, M., R. Kureshi, L. Hingorani, et al. "FORMULATION AND EVALUATION OF SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM FOR SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT OF POORLY WATER SOLUBLE WITHAFERIN A." INDIAN DRUGS 52, no. 10 (2015): 49–54. http://dx.doi.org/10.53879/id.52.10.10411.

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Withaferin A, a steroidal lactone which is present in dry root extract of Withania somnifera (WSE), is reported to possess numerous pharmacological activities and shows poor aqueous solubility. The purpose of this study is to enhance the dissolution rate and oral bioavailability of WSE by incorporating it in self nano emulsifying drug delivery system (SNEDDS). Capmul MCM-based SNEDDS formulation with Tween 20 as surfactant and ethanol as co surfactant was developed for oral delivery of withaferin A. Optimised SNEDDS was evaluated for its self-emulsification time and viscosity, droplet size. Th

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Vishal N Kushare and Saravanan S. "Formulation and Evaluation of Herbal Drug Loaded Self Nano Emulsifying Drug Delivery System (SNEDDS)." International Journal of Pharmacometrics and Integrated Biosciences 3, no. 2 (2018): 26–36. http://dx.doi.org/10.26452/ijpib.v3i2.1278.

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The goal of this research was to formulate and test invitro the self-nano emulsifying drug delivery system (SNEDDS) of poorly water-soluble herbal material. Linalool, an essential of Coriandrum sativum with anti-epileptic activity, was isolated from Coriandrum sativum by using Soxhlet extraction method followed by column chromatography and fractionates are concentrated under reduced pressure by using rotary flash evaporator. It is low water soluble material; unpredictable dissolution and low bioavailability make it very difficult to administer linalool orally.The captex-200 oil was exhibited m

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Abdulkareem, Noor, and Mohanad Naji Sahib. "Self emulsifying drug delivery system: norfloxacin model drug." F1000Research 12 (October 20, 2023): 1380. http://dx.doi.org/10.12688/f1000research.141057.1.

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Background Norfloxacin is a synthetic antibacterial fluoroquinolone that is poorly water soluble and active against a wide spectrum of gram-positive and gram-negative aerobic bacteria. The goal of this work was to create a self-nanoemulsion (SNE) as a colloidal dispersed drug delivery system for increasing norfloxacin dissolving rate, while also assuming intestinal lymphatic transport participation for such a nano-size system that would increase norfloxacin oral bioavailability. Methods Depending on the solubility of norfloxacin in various components, several formulations of liquid SNEDDS of t

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Tungadi, Robert, Nur Ain Thomas, and Wanda Gita Van Gobel. "Formulasi, Karakterisasi, Dan Evaluasi Drops Liquid Self Nano-Emulsifying Drug Delivery System (SNEDDS) Astaxanthin." Indonesian Journal of Pharmaceutical Education 1, no. 3 (2021): 168–78. http://dx.doi.org/10.37311/ijpe.v1i3.11400.

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SNEDDS are isotropic mixtures of oil, surfactant, and cosurfactant that produce spontaneous nanoemulsions once they make contact with gastric juices in order to increase the solubility of active pharmaceutical ingredients. One of the active pharmaceutical ingredients with low solubility is Astaxanthin. This research aims at formulating, characterizing, and evaluating SNEDDS containing Astaxanthin in the form of droplets. This research is a laboratory experiment. SNEDDS containing Astaxanthin droplets are made in 3 formulas using the ratio of surfactants and co-surfactants which are characteriz

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Syukri, Yandi, Yuvina Seran, Hannie Fitriani, Arba Pramundita Ramadhani, and Muhammad Taher. "Formulation and Characterization of Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS) Loading Curcuma xanthorrhiza Extract." Jurnal Sains Farmasi & Klinis 11, no. 3 (2025): 169–78. https://doi.org/10.25077/jsfk.11.3.169-178.2024.

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Curcuma xanthorrhiza has an active component xanthorrhizol that is poorly soluble in water, resulting in limited absorption and bioavailability. Liquid Self Nano Emulsifying Drug Delivery System (SNEDDS) dosage formulations can improve its solubility and absorption due to its small particle size. Solid SNEDDS technology significantly overcomes some of problems in liquid SNEDDS preparations to improve the stability of liquid formulations. This study aims to formulate and characterize Curcuma xanthorrhiza S-SNEDDS preparation. SNEDDS was characterized by particle size and thermodynamic tests. Me

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Gayathri, T., M. Venkata Ramana, and N. Rama Rao. "Formulation and Evaluation of Self Nano Emulsifying Drug Delivery System of Raloxifene Hydrochloride." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 16–19. http://dx.doi.org/10.22270/jddt.v11i4.4857.

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Raloxifene hydrochloride (RLX) is a selective Estrogen-receptor modulator used to treat osteoporosis as well as breast and endometrial cancer prevention. The bioavailability of RLX is only 2% due to substantial pre-systemic clearance. The goal of this research was to customise and characterise RLX-loaded self-nanoemulsifying drug-delivery systems (SNEDDS) by using bioactive excipients that impact drug metabolism. The droplet size, zeta potential and drug content determination of optimized formulation (F-06) was found to be 147.5 nm, -28.8, 99.67% respectively. The drug release study from the n

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B, Medha Gayatri, and Vasanthi A. V. "SNEDDS- A New Frontier in Oral Drug Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 18, no. 1 (2025): 7895. https://doi.org/10.37285/ijpsn.2025.18.1.16.

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Self-Nano-Emulsifying Drug-Delivery Systems (SNEDDS) are a novel method to increase the oral bioavailability of poorly soluble drugs and are one of the latest in the business today. Such systems are composed of oil, surfactant, and co-surfactant, which can, in the wake of their dilution in aqueous media, instantaneously produce the nano emulsions. The small-scale dispersion of the drug in the system leads to its solubilization and absorption, which in turn results in better therapeutic efficacy.

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Ricardo, I. Komang Aan Adi, and Dewa Ayu Arimurni. "Optimization of self-nano emulsifying drug delivery system of rifampicin for nebulization using cinnamon oil as oil phase." Pharmaciana 14, no. 3 (2024): 356–69. https://doi.org/10.12928/pharmaciana.v14i3.28892.

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Lung delivery can overcome the problems related to the effectiveness of tuberculosis treatment by increasing the drug concentration at the target site. Rifampicin as the first-line antibiotic for tuberculosis has low water solubility and is unstable in gastric which hinders its effectiveness. Self-nanoemulsifying drug delivery system (SNEDDS) is a strategy known to improve the solubility and stability of such drugs. This study aimed to obtain the optimum formula of rifampicin SNEDDS intended for lung nebulization using essential oil as an oil phase. Several essential oils are known to have eff

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Geethanjali K and Vaiyana Rajesh C. "Formulation and evaluation of self nano-emulsifying drug delivery system of ezetimibe for dissolution rate enhancement." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 1294–301. http://dx.doi.org/10.26452/ijrps.v11i2.1984.

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The present study was aimed to develop a Self Nano Emulsifying Delivery System of Ezetimibe (EZM) for enhancing its dissolution rate. Ezetimibe is a cholesterol absorption inhibitor, being a lipophilic drug due to its low solubility EZM shows a low dissolution profile. The SNEDDS formulation consisted of excipients Cinnamon oil, Tween 80, PEG 400 as the Oil, Surfactant and Co-surfactant. Twelve formulations with different ratios of Oil, Surfactant and Co-surfactant were prepared. The liquid SNEDDS were then converted into Solid form by adsorption technique using Avicel PH 101 and Aerosil 200 a

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Putri, Cynthia Astiti, Farida Hayati, Lutfi Chabib, and Muhammad Iqbal Pangestu. "Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats." Borneo Journal of Pharmacy 6, no. 1 (2023): 1–7. http://dx.doi.org/10.33084/bjop.v6i1.2099.

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Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study aimed to investigate SNEDDS of I. reptans acute toxicity in female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into control and treatment groups, with three animals for each group being used per step. No animals died after they we

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Rajput, Rakesh, Simranjot Kaur, Yogiraj Ingole, Narendra Kumar Pandey, Kashish Wilson, and Swarupanjali Padhi. "Enhancement of bioavailability of herbal drugs for treating viral therapy using SNEDDS as the delivery system." BIO Web of Conferences 86 (2024): 01012. http://dx.doi.org/10.1051/bioconf/20248601012.

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SNEDDS were developed with the objective of treating low bioavailability of drugs for antiviral drugs due to its low solubility. The scientist has increased their interest in improving bioavailability and absorption of poorly-water soluble drugs using Self-Emulsifying lipid technology. SNEDDS was an isocratic mixture contains an Oil, Surfactant, Co-surfactant, and Drug in accurate amount. The SNEDDS was primarily prepared as liquid-SNEDDS, but S-SNEDDS was more stable as compared to L-SNEDDS. As viral infection was major threat for people due to its limited efficacy and Serious adverse effects

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Shrivastava, Nupur, Ankit Parikh, Rikeshwer Prasad Dewangan, et al. "Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer." Pharmaceutics 14, no. 7 (2022): 1486. http://dx.doi.org/10.3390/pharmaceutics14071486.

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The solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which is a potent chemotherapeutic, antioxidant, anti-inflammatory and P-gp inhibitor for enhancing bioavailability and to obtain synergistic anti-cancer effect against breast cancer. SNEDDS were developed using capmul MCM as oil, Tween 80 as surfactant and transcutol-HP as co-surfactant and optimized by central composite rotatable design. Neusilin US2 concentration was optimized for adso

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Wijayanti, Ifa Rizki, Ilham Kuncahyo, and Wiwin Herdwiani. "Skrining dan Karakterisasi Komponen Self Nano Emulsifying Drug Delivery System (SNEDDS) Atorvastatin Menggunakan Fractional Factorial Design (FFD)." Jurnal Mandala Pharmacon Indonesia 10, no. 2 (2024): 346–55. https://doi.org/10.35311/jmpi.v10i2.546.

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Atorvastatin merupakan obat yang memiliki kelarutan rendah dalam air (BCS kelas II) serta memiliki aktivitas farmakologis sebagai terapi hiperkolesterolemia. Self?nanoemulsifying drug delivery systems (SNEDDS) dianggap sebagai pendekatan yang potensial untuk meningkatkan kelarutan atorvastatin karena stabil dan proses pembuatan yang relatif sederhana. Penelitian ini bertujuan untuk memilih komponen dan rasio komponen SNEDDS atorvastatin menggunakan pendekatan desain faktorial terfraksi (DFT) terhadap parameter waktu emulsifikasi, ukuran droplet, indeks polidispersitas (PDI), zeta potensial, pe

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Syukri, Yandi, Bambang Hernawan Nugroho, and Istanti Istanti. "Penggunaan D-Optimal Mixture Design untuk Optimasi dan Formulasi Self-Nano Emulsifying Drug Delivery System (SNEEDS) Asam Mefenamat." Jurnal Sains Farmasi & Klinis 7, no. 3 (2020): 180. http://dx.doi.org/10.25077/jsfk.7.3.180-187.2020.

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Penelitian ini bertujuan untuk melakukan optimasi formulasi asam mefenamat yang sukar larut dalam air dalam bentuk sediaan Self-Nano Emulsifying Drug Delivery System (SNEDDS) menggunakan D-optimal mixture design. Skrining awal dilakukan untuk menentukan fase minyak, surfaktan dan ko-surfaktan yang akan digunakan untuk pembuatan diagram fase terner. D-optimal mixture design digunakan untuk mengoptimasi SNEDDS asam mefenamat dengan memilih komposisi SNEDDS sebagai faktor independent dan karakterisasi SNEDDS sebagai respons. Karakterisasi SNEDDS pada formula optimal meliputi transmitan, ukuran pa

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Adella, Aparna, and Shravan K. Yamsani. "Formulation and In-vivo Studies of Clopidogrel by Self-nanoemulsifying Drug Delivery System." International Journal of Pharmaceutical Sciences and Drug Research 13, no. 05 (2020): 479–87. http://dx.doi.org/10.25004/ijpsdr.2021.130504.

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A self-nano emulsifying drug delivery system (SNEDDS) has been explored to improve poorly watersoluble drug clopidogrel’s solubility and dissolution rate. Different formulations were prepared using oil, surfactant, and co-surfactant in varying ratios. From the ternary phase diagram resultant formulations were investigated for clarity, phase separation, drug content, % transmittance, globule size, freeze-thaw, in vitro dissolution studies, particle size analysis, and zeta potential. Based on particle size, zeta potential and dissolution profile, and other studies, F6 was the best formulation of

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Ahmed Raka, Marzeea, Suraiya Ahmed, Nusrat Alam Mou, et al. "Preparation and Development of Self Nano Emulsifying Drug Delivery System of Curcumin." Journal of Biosciences and Experimental Pharmacology 2, no. 1 (2023): 14–30. https://doi.org/10.62624/jbep00.0008.

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Curcumin, the main pharmacologic agent in turmeric, is known to have a wide spectrum of biological and pharmacological activities which could be utilized in various medical applications; however, it is unable to be used in a formulation due to its poor water solubility. In order to overcome solubility issue, curcumin can be formulated into a self-nanoemulsifying drug delivery system (SNEDDS). Therefore, solubility of curcumin was first tested in various oils including castor oil (with highest solubility around 72%), soyabean oil (solubility of 56%), black seed oil (with least solubility around

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Kazi, Mohsin, Ahmad A. Shahba, Saad Alrashoud, Majed Alwadei, Abdelrahman Y. Sherif, and Fars K. Alanazi. "Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine." Molecules 25, no. 7 (2020): 1703. http://dx.doi.org/10.3390/molecules25071703.

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Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation. Methods: The self-emulsifying properties of apricot, avocado, black seed and Zanthoxylum rhetsa seed oils were screened within various SNEDDS formulations. Each liquid SNEDDS formulation was loaded with both CUR and PP. The optimal liquid SNEDDS were solidified using Aeroperl® and Neusilin®

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Liu, Chunxia, Li Lv, Wei Guo, et al. "Self-Nanoemulsifying Drug Delivery System of Tetrandrine for Improved Bioavailability: Physicochemical Characterization and Pharmacokinetic Study." BioMed Research International 2018 (September 27, 2018): 1–10. http://dx.doi.org/10.1155/2018/6763057.

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The main purpose of this study was to investigate the potential of self-nanoemulsified drug delivery system (SNEDDS) to improve the oral bioavailability of tetrandrine (Tet). SNEDDS was developed by using rational blends of excipients with good solubilizing ability for Tet which was selected based on solubility studies. Further ternary phase diagram was constructed to determine the self-emulsifying region. The optimal formulation with the best self-nanoemulsified and solubilization ability consisted of 40% (w/w) oleic acid as oil, 15% (w/w) SPC and 30% (w/w) Cremophor RH-40 as surfactant, and

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Wijiyanto, Budy, Primadara Damayanti, Mira Amaliasari Sitorus, Ratih Dyah Listianingrum, Arifa Caryn Dea, and Yandi Syukri. "Formulasi Sediaan Nano Herbal Tempuyung (Sonchus arvensis L.) dalam Bentuk Self Nano-Emulsifying Drug Delivery System (SNEDDS)." Jurnal Sains Farmasi & Klinis 3, no. 1 (2016): 50. http://dx.doi.org/10.29208/jsfk.2016.3.1.99.

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Tempuyung (Sonchus arvensis L.) merupakan tanaman asli Indonesia yang berhkasiat sebagai diuretik dan antioksidan. Untuk mendapatkan efek terapi yang optimal perlu inovasi untuk membuatnya menjadi sediaan nano herbal. Penelitian ini bertujuan membuat sediaan nano herbal tempuyung dalam bentuk Self Nano-Emulsifying Drug Delivery System (SNEDDS). Kandungan zat aktif tempuyung diekstraksi dengan etanol dan berikut diuapkan pelarutnya untuk mendapatkan ekstrak kental. Ekstrak yang diperoleh distandarisasi menurut Farmakope Herbal Indonesia. Berikutnya dibuat SNEDDS tempuyung dengan menggunakan min

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Mohd Izham, Mira Nadiah, Yazmin Hussin, Muhammad Nazirul Mubin Aziz, et al. "Preparation and Characterization of Self Nano-Emulsifying Drug Delivery System Loaded with Citraland Its Antiproliferative Effect on Colorectal Cells In Vitro." Nanomaterials 9, no. 7 (2019): 1028. http://dx.doi.org/10.3390/nano9071028.

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Citral is an active compound naturally found in lemongrass, lemon, and lime. Although this pale-yellow liquid confers low water solubility, the compound has been reported to possess good therapeutic features including antiproliferative and anticancer modalities. The self nano-emulsifying drug delivery system (SNEDDS) is a type of liquid-lipid nanocarrier that is suitable for the loading of insolubilized oil-based compound such as Citral. This study reports the design and optimization of a SNEDDS formulation, synthesis and characterization as well as loading with Citral (CIT-SNEDDS). Further as

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Mohanty, Smitapadma. "Self-micro emulsifying drug delivery systems: State-of-art a technology to enhance the solubility of poorly water-soluble drug." Journal of medical pharmaceutical and allied sciences 11, no. 6 (2022): 5368–74. http://dx.doi.org/10.55522/jmpas.v11i6.4162.

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As new technologies are invented, research in the discovery of new active pharmaceutical moieties is reverberating now a day. Drug solubility is an extensive challenge for formulation scientists as approximately 35-40% of newly discovered drugs show lipophilicity. Low solubility is a rate limiting step for drug dissolution and extends of drug absorption to the systemic circulation. Poor dissolution results in low bioavailability, leading to difficulty to achieve desired therapeutic effect. Drug solubility can be increased by different methods like micronization, solid dispersion, salt formatio

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Arshad, Rabia, Muhammad Salman Arshad, Tanveer A. Tabish, Syed Nisar Hussain Shah, Saira Afzal, and Gul Shahnaz. "Amidated Pluronic Decorated Muco-Penetrating Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Improved Anti-Salmonella typhi Potential." Pharmaceutics 14, no. 11 (2022): 2433. http://dx.doi.org/10.3390/pharmaceutics14112433.

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The enteric system residing notorious Salmonella typhimurium (S. typhi) is an intracellular, food-borne, and zoonotic pathogen causing typhoid fever. Typhoid fever is one of the leading causes of mortality and morbidity in developing and underdeveloped countries. It also increased the prevalence of multidrug resistance globally. Currently, available anti-bacterial modalities are unable to penetrate into the intracellular compartments effectively for eradicating S. typhi infection. Therefore, in this study, we developed nanostructured lipid-based carriers in the form of a self-nanoemulsifying d

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Wu, Fengying, Qing Ma, Guanghui Tian, Kaixian Chen, Rulei Yang, and Jingshan Shen. "Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Cannabidiol for Enhanced Solubility and Bioavailability." Pharmaceutics 17, no. 3 (2025): 340. https://doi.org/10.3390/pharmaceutics17030340.

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Background/Objectives: This study aims to develop a solid self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and oral bioavailability of cannabidiol (CBD). Methods: According to the solubility of CBD and pseudo-ternary phase diagrams of the different ingredients, an oil (medium-chain triglyceride, MCT), mixed surfactants (Labrasol, Tween 80), and a co-surfactant (Transcutol) were selected for the SNEDDS. CBD-loaded SNEDDS formulations were prepared and characterized. The optimal SNEDDS was converted into solid SNEDDS powders via solid carrier adsorption and spray dryi

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Buya, Aristote B., Romano Terrasi, Jérémie K. Mbinze, et al. "Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes." Pharmaceutics 13, no. 9 (2021): 1388. http://dx.doi.org/10.3390/pharmaceutics13091388.

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Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed. Various oils, surfactants, and cosurfactants were screened for their solubilization potential for the drug. The area of nanoemulsification was identified using a ternary phase diagram. An experimental mixture design and a desirability function were applied to select SNEDDSs that contain a maximum amount of lipids and a minimum amount of surfactant, and that possess

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