Relevant bibliographies by topics / Serine hydrolases

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Academic literature on the topic 'Serine hydrolases'

Author: Grafiati
Published: 8 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Serine hydrolases"

1

Goss, Allison L., Renee E. Shudick, and R. Jeremy Johnson. "Shifting Mycobacterial Serine Hydrolase Activity Visualized Using Multi-Layer In-Gel Activity Assays." Molecules 29, no. 14 (2024): 3386. http://dx.doi.org/10.3390/molecules29143386.

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The ability of Mycobacterium tuberculosis to derive lipids from the host, store them intracellularly, and then break them down into energy requires a battery of serine hydrolases. Serine hydrolases are a large, diverse enzyme family with functional roles in dormant, active, and reactivating mycobacterial cultures. To rapidly measure substrate-dependent shifts in mycobacterial serine hydrolase activity, we combined a robust mycobacterial growth system of nitrogen limitation and variable carbon availability with nimble in-gel fluorogenic enzyme measurements. Using this methodology, we rapidly an
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Nishioka, Tuguhiro, Makoto Iwata, Takuya Imaoka, et al. "A Mono-2-Ethylhexyl Phthalate Hydrolase from a Gordonia sp. That Is Able To Dissimilate Di-2-Ethylhexyl Phthalate." Applied and Environmental Microbiology 72, no. 4 (2006): 2394–99. http://dx.doi.org/10.1128/aem.72.4.2394-2399.2006.

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ABSTRACT Gordonia sp. strain P8219, a strain able to decompose di-2-ethylhexyl phthalate, was isolated from machine oil-contaminated soil. Mono-2-ethylhexyl phthalate hydrolase was purified from cell extracts of this strain. This enzyme was a 32,164-Da homodimeric protein, and it effectively hydrolyzed monophthalate esters, such as monoethyl, monobutyl, monohexyl, and mono-2-ethylhexyl phthalate. The Km and V max values for mono-2-ethylhexyl phthalate were 26.9 ± 4.3 μM and 18.1 ± 0.9 μmol/min · mg protein, respectively. The deduced amino acid sequence of the enzyme exhibited less than 30% hom
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Jeremy Johnson, R., Andrew Bartels, Rachel Erkilla, et al. "Proteopedia entry: Mammalian serine hydrolases." Biochemistry and Molecular Biology Education 43, no. 1 (2014): 60–61. http://dx.doi.org/10.1002/bmb.20840.

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Botos, Istvan, and Alexander Wlodawer. "The expanding diversity of serine hydrolases." Current Opinion in Structural Biology 17, no. 6 (2007): 683–90. http://dx.doi.org/10.1016/j.sbi.2007.08.003.

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Tang, Shan, Adam T. Beattie, Lucie Kafkova, et al. "Mechanism-based traps enable protease and hydrolase substrate discovery." Nature 602, no. 7898 (2022): 701–7. http://dx.doi.org/10.1038/s41586-022-04414-9.

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AbstractHydrolase enzymes, including proteases, are encoded by 2–3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases—especially those embedded in membranes—and other hydrolases remain unknown. Here we report a strategy for creating mechanism-based, light-activated protease and hydrolase substrate traps in complex mixtures and live mammalian cells. The traps capture substrates of hydrolases, which normally use a serine or cysteine nucleophile. Replacing the catalytic nucleophile with genetic
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Liu, Y., M. P. Patricelli, and B. F. Cravatt. "Activity-based protein profiling: The serine hydrolases." Proceedings of the National Academy of Sciences 96, no. 26 (1999): 14694–99. http://dx.doi.org/10.1073/pnas.96.26.14694.

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Ross, Matthew K., and Ran Wang. "Expanding the Toolkit for the Serine Hydrolases." Chemistry & Biology 22, no. 7 (2015): 808–9. http://dx.doi.org/10.1016/j.chembiol.2015.07.002.

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Hernáez, M. J., E. Andújar, J. L. Ríos, S. R. Kaschabek, W. Reineke, and E. Santero. "Identification of a Serine Hydrolase Which Cleaves the Alicyclic Ring of Tetralin." Journal of Bacteriology 182, no. 19 (2000): 5448–53. http://dx.doi.org/10.1128/jb.182.19.5448-5453.2000.

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ABSTRACT A gene designated thnD, which is required for biodegradation of the organic solvent tetralin by Sphingomonas macrogoltabidus strain TFA, has been identified. Sequence comparison analysis indicated that thnD codes for a carbon-carbon bond serine hydrolase showing highest similarity to hydrolases involved in biodegradation of biphenyl. An insertion mutant defective in ThnD accumulates the ring fission product which results from the extradiol cleavage of the aromatic ring of dihydroxytetralin. The gene product has been purified and characterized. ThnD is an octameric thermostable enzyme
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Bernhardt, Peter, Karl Hult, and Romas J. Kazlauskas. "Molecular Basis of Perhydrolase Activity in Serine Hydrolases." Angewandte Chemie International Edition 44, no. 18 (2005): 2742–46. http://dx.doi.org/10.1002/anie.200463006.

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Bernhardt, Peter, Karl Hult, and Romas J. Kazlauskas. "Molecular Basis of Perhydrolase Activity in Serine Hydrolases." Angewandte Chemie 117, no. 18 (2005): 2802–6. http://dx.doi.org/10.1002/ange.200463006.

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Dissertations / Theses on the topic "Serine hydrolases"

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Fransson, Linda. "Enzyme substrate solvent interactions : a case study on serine hydrolases." Doctoral thesis, KTH, Biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4867.

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Reaction rates and selectivities were measured for transacylation of fatty acid esters in solvents catalysed by Candida antarctica lipase B and by cutinase from Humicola insolens. With these enzymes classical water-based enzymology can be expanded to many different solvents allowing large variations in interaction energies between the enzymes, the substrates and the surrounding. Further ,hydrolysis reactions catalysed by Bacillus subtilis esterase 2 were investigated. Thermodynamics analyses revealed that the enzyme contribution to reaction rate acceleration compared to acid catalysis was pure
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Elahi, AEM Rubayet. "Proteome-wide Functional Profiling of Serine Hydrolases in the Human Malaria Parasite." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/90181.

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The serine hydrolase (SH) enzyme superfamily is one of the largest and most diverse enzyme classes in eukaryotes and prokaryotes. The most virulent human malaria parasite Plasmodium falciparum has over 40 predicted serine hydrolases (SH). Prior investigation on a few of these have suggested their critical role in parasite biology. The majority of the SHs in P. falciparum have not been functionally characterized. Investigation of these uncharacterized SHs will provide new insights into essential features of parasite metabolism and possibly lead to new antimalarial targets. In this study, we hav
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Galmés, Ordinas Miquel Àngel. "Molecular insights into the promiscuity of serine hydrolases. Towards a computationally guided protocol for the redesign of enzymes." Doctoral thesis, Universitat Jaume I, 2022. http://dx.doi.org/10.6035/14122.2022.725777.

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Two serine hydrolases, Candida antarctica Lipase B (CALB) and para-nitrobenzyl (Bs2) esterase from Bacillus subtilis, were used as a model to study enzyme promiscuity through QM/MM methods and experimental enzymes kinetics. Both, the catalytic and the substrate promiscuity were studied. The hydrolysis of amides and the epoxidation of alkenes catalyzed by CALB were explored. Moreover, a computational scheme for the redesign of the Bs2 was also proposed. The electrostatic environment around the active site was analyzed and a map of structural determinants in the vicinity of the active site pocke
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Kreuzer, Johannes Verfasser], Stephan A. [Akademischer Betreuer] Sieber, and Aymelt [Akademischer Betreuer] [Itzen. "The Natural Product Acivicin as a Tool for ABPP and the Activity of Serine Hydrolases in Uterine Fibroids / Johannes Kreuzer. Gutachter: Aymelt Itzen ; Stephan A. Sieber. Betreuer: Stephan A. Sieber." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1071651544/34.

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Yedji, Rodrigue. "Perturbateurs endocriniens de type phtalate et poisson zèbre Danio rerio : approche chémoprotéomique pour l'identification des cibles et recherche de signatures d'exposition." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0106.

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Les esters de phtalate constituent une famille de composés synthétiques très répandue du fait de leurs usages comme plastifiants. Ils entrent dans la composition de plusieurs produits plastiques tels que les emballages, les jouets, les produits cosmétiques, certains systèmes de toiture en plastique, ainsi que les matériaux de décoration de meubles. Les phtalates ne sont pas liés de manière covalente à la matrice des polymères et sont donc facilement rejetés dans l'environnement, entraînant par conséquent une exposition animale et humaine. En absence de produits de substitutions non-toxiques, l
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Hamberg, Anders. "Serine Hydrolase Selectivity : Kinetics and applications in organic and analytical chemistry." Doctoral thesis, KTH, Biokemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12831.

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The substrate selectivities for different serine hydrolases were utilized in various applications, presented in papers I-VI. The articles are discussed in the thesis in view of the kinetics of the enzyme catalysis involved. In paper I the enantioselectivities towards a range of secondary alcohols were reversed for Candida antarctica lipase B by site directed mutagenesis. The thermodynamic components of the enantioselectivity were determined for the mutated variant of the lipase. In papers II-III Candida antarctica lipase B was engineered for selective monoacylation using two different approach
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Hamon, Nadège. "Synthese de nucleosides en serie carbocyclique à visée antivirale." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20087/document.

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Les analogues nucléosidiques constituent une famille importante d'agents thérapeutiques dans le traitement de maladies d'origine virale. Parmi ces composés, les nucléosides carbocycliques possèdent des propriétés biologiques intéressantes. Le premier chapitre de cette thèse est consacrée à la famille des neplanocines qui sont des carbonucleosides naturels. Nous avons détaillé l'interaction de ces composés avec leur principale cible, la S-adénosylhomocystéine hydrolase, ainsi que les différentes approches de synthèses de ces carbonucléosides et de leurs énantioméres avant de passer en revue leu
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Ambrose, Timothy James William. "Serine hydrolase activity and roles for monoacylglycerol lipase in innate immunity and intestinal inflammation." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:f7a12796-ae8f-4121-ab1a-26778261ac78.

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Detection of evolutionarily conserved pathogen motifs by pattern recognition receptors (PRRs), particularly on dendritic cells (DCs), is crucial for adequate immune responses. Defects in DC function are known to be associated with inflammatory bowel disease (IBD). The endocannabinoid system (ECS) is the system through which exocannabinoids such as Δ<sup>9</sup>-tetrahydrocannabinol and cannabidiol signal. Regarding inflammation, cannabinoids generally exert anti-inflammatory effects, including on experimental colitis. However, most work has been performed in animal models and less is known abo
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Ho, Cherry Pei-Yee. "Evaluation of a Serine Hydrolase Inhibitor JZL184 as an Immunomodulator against Avian Pathogenic Escherichia Coli O78 in Chickens." Thesis, Mississippi State University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10788360.

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<p> Studies with the serine hydrolase inhibitor JZL184 have suggested that enhanced 2-arachidonoylglycerol signaling could be strategized to stimulate innate immune cells to combat invading pathogens and improve host defense by prompting the systemic release of proinflammatory cytokines. Although the neurochemical effects of JZL184 were found to cultivate within 30 min in mice, its immune-regulating effects have been studied much later and its effects on chickens have not been clear. To explore the modulations in the chickens&rsquo; immune responses, we studied the effects of intraperitoneal i
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Kornahrens, Anne. "Methodology development and synthesis of a biologically relevant natural product and targeted scaffold discovery for serine hydrolase inhibition." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:4cf5026f-e421-4b0b-9f62-707622f780b7.

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The phenomenal potential of synthetic chemistry to influence small molecule therapeutic development represents my overarching theme. The goal of designing or discovering a novel clinical candidate or biological target can be achieved through a variety of avenues available to synthetic organic chemists. The potential of natural product total synthesis and inhibitor development as impactful projects were pursued with the use and development of methodology. The natural product streptonigrin, a potent antitumor antibiotic, showed promise in clinical trials ultimately terminated in the 1970s. The u
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Books on the topic "Serine hydrolases"

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Barrett, Alan J., John N. Abelson, and Melvin I. Simon. Proteolytic Enzymes: Serine and Cysteine Peptidases. Elsevier Science & Technology Books, 1994.

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Proteolytic Enzymes: Serine and Cysteine Peptidases, Volume 244 (Methods in Enzymology). Academic Press, 1994.

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(Editor), John N. Abelson, Melvin I. Simon (Editor), and Alan J. Barrett (Editor), eds. Proteolytic Enzymes: Serine and Cysteine Peptidases, Volume 244 (Methods in Enzymology). Academic Press, 1994.

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Barrett, Alan J., John N. Abelson, and Melvin I. Simon. Proteolytic Enzymes: Aspartic and Metallo Peptidases. Elsevier Science & Technology Books, 1995.

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Tiezzi, Antonio, Elisa Ovidi, and Tomasz M. Karpiński, eds. New Findings from Natural Substances. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150514211220101.

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New Findings from Natural Substances present the state-of-the-art and future prospects for the application of biomolecules in the pharmaceutical, agricultural, food and industrial sectors. The book presents eight reviews contributed by more than twenty experts on interesting natural substances, and plant sources, that serve as sources of natural remedies for a variety of ailments. The reviews in the book cover the use of herbs like Heliotropium and Astragalus. Additional health benefits of extracts from essential oils, Caenorhabditis elegans, and olive oil, as well as the medicinal use of rosm
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Book chapters on the topic "Serine hydrolases"

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Schomburg, Dietmar, and Ida Schomburg. "L-serine-phosphatidylethanolamine phosphatidyltransferase 2.7.8.29." In Class 2–3.2 Transferases, Hydrolases. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36240-8_99.

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Schomburg, Dietmar, and Ida Schomburg. "D-alanine-d-serine ligase 6.3.2.35." In Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36260-6_93.

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Schomburg, Dietmar, and Ida Schomburg. "O-phospho-l-serine-tRNA ligase 6.1.1.27." In Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36260-6_84.

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Baggelaar, Marc P., and Mario Van der Stelt. "Competitive ABPP of Serine Hydrolases: A Case Study on DAGL-Alpha." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6439-0_12.

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Uddin, Md Jalal, Jeanette S. Grunnvåg, and Christian S. Lentz. "Activity-Based Protein Profiling of Serine Hydrolases in Bacteria: Methods and Protocols." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4502-4_3.

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Li, Xuanwen, Taku Tsukidate, Alyssa Q. Stiving, and Hillary A. Schuessler. "Activity-Based Protein Profiling of Active Host Cell Serine Hydrolases for Bioprocess Development of Therapeutic Proteins and Vaccines." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4502-4_10.

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Deng, Shiping, and Inna Popova. "Carbohydrate Hydrolases." In SSSA Book Series. American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, 2015. http://dx.doi.org/10.2136/sssabookser9.c9.

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Ding, Shi-You, William S. Adney, Todd B. Vinzant, et al. "Glycoside Hydrolase Gene Cluster ofAcidothermus cellulolyticus." In ACS Symposium Series. American Chemical Society, 2003. http://dx.doi.org/10.1021/bk-2003-0855.ch020.

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Hong, Tram Ngoc, and Renier A. L. van der Hoorn. "DIGE-ABPP by Click Chemistry: Pairwise Comparison of Serine Hydrolase Activities from the Apoplast of Infected Plants." In Methods in Molecular Biology. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-986-4_15.

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Moris-Varas, Francisco, Laura Hartman, Amit Shah, and David C. Demirjian. "Screening of Hydrolase Libraries Using pH-Shift Reagents: Rapid Evaluation of Enantioselectivity." In ACS Symposium Series. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0776.ch003.

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Conference papers on the topic "Serine hydrolases"

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Rüedi, P., W. Ganci, and U. Ringeisen. "Synthesis of Rigid Acetylcholine Mimics as Inhibitors of Serine Hydrolases." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02032.

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Rüedi, P., S. Furegati, A. Linden, G. Przibille, and D. Rentsch. "Synthesis, ee-Determination and Absolute Configuration of Chiral Organophosphorus Inhibitors of Serine Hydrolases." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02031.

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Sajic, Tatjana, Stephan Arni, Walter Weder, Rudolf Aebersold, and Sven Hillinger. "Abstract 4934: Modified SWATH MS analysis of serine hydrolase activity in lung adenocarcinoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4934.

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Sajic, Tatjana, Stephan Arni, Walter Weder, Rudolf Aebersold, and Sven Hillinger. "Abstract 4934: Modified SWATH MS analysis of serine hydrolase activity in lung adenocarcinoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4934.

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Taylor, N. M., A. Walker, D. Nicoletti, et al. "Comparative Analysis of Microbiological Testing Technologies Used in the Energy Industry." In SPE Annual Technical Conference and Exhibition. SPE, 2024. http://dx.doi.org/10.2118/220734-ms.

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Abstract Within the energy industry, there are several technologies used to quantify microbiological contamination of fluids and assets. Some of these technologies can also be used to identify or characterize microorganisms of interest. It is important to understand the scope of detection and limitations of individual assays so that accurate, data-driven decisions can be made. Three fluids varying in chemical composition and origin within the energy sector were tested in this study. Serial dilution for detection of acid producing bacteria (APB) and sulfate reducing bacteria (SRB), activity-rea
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