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Journal articles on the topic 'Sery'

Author: Grafiati

Published: 12 December 2022

Last updated: 31 July 2025

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1

Zaracho Paniagua, Nadia Denisse, Yasmine Maluff Ladan, Liliana Noelia Talavera Stefani, Yanina Dionisia Sapper Lacy, Carolina Elizabeth Prendeski Stolaruk, and Eliane Aya Nishii Encina. "Fe de erratas de “Glaesserella parasuis: serotipos y virulencia de cepas aisladas de cerdos en Itapúa-Paraguay entre febrero del 2022 a marzo del 2023” a marzo del 2023." Investigaciones y estudios - UNA 14, no. 2 (2023): 74. http://dx.doi.org/10.57201/ieuna2323937.

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Los autores se disculpan sinceramente por el error involuntario en la composición tipográfica en la página 87, sección Materiales y Métodos. El contenido completo de dicha sección debe ser el siguiente la inclusión se visualiza en negrita: Tipificación molecular y virulencia. Para realizar la tipificación molecular se utilizaron los cebadores descritos por Howell (2015), con modificaciones hechas por Lacouture et al. (2017). Fueron utilizadas tres mezclas de cebadores que se detallan a continuación: PM1: funB (Ser1), glyC (Ser3), wciP (Ser4), funQ (Ser7), funAB (Ser14); PM2: wzx (Ser2), funV (

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Ziarno, Małgorzata. "Sery z mikrobów?" PRZEMYSŁ SPOŻYWCZY 1, no. 10 (2021): 47–51. http://dx.doi.org/10.15199/65.2021.10.6.

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De Bock, V., H. De Backer, R. Van Malderen, A. Mangold, and A. Delcloo. "Relations between erythemal UV dose, global solar radiation, total ozone column and aerosol optical depth at Uccle, Belgium." Atmospheric Chemistry and Physics 14, no. 22 (2014): 12251–70. http://dx.doi.org/10.5194/acp-14-12251-2014.

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Abstract. At Uccle, Belgium, a long time series (1991–2013) of simultaneous measurements of erythemal ultraviolet (UV) dose (Sery), global solar radiation (Sg), total ozone column (Q_{O3}$) and aerosol optical depth (τaer) (at 320.1 nm) is available, which allows for an extensive study of the changes in the variables over time. Linear trends were determined for the different monthly anomalies time series. Sery, Sg and QO3 all increase by respectively 7, 4 and 3% per decade. τaer shows an insignificant negative trend of −8% per decade. These trends agree with results found in the literature for

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Stasiak-Różańska, Lidia. "Sery pleśniowe występowanie bakterii Listeria monocytogenes." PRZEMYSŁ SPOŻYWCZY 1, no. 3 (2018): 38–42. http://dx.doi.org/10.15199/65.2018.3.7.

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Godula, Krzysztof, Izabela Dmytrów, Anna Mituniewicz-Małek, and Elżbieta Mulawka. "Stabilność przechowalnicza twarogów tradycyjnych i bezlaktozowych." Zywnosc Nauka Technologia Jakosc/Food Science Technology Quality 117, no. 4 (2018): 140–49. http://dx.doi.org/10.15193/zntj/2018/117/265.

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Zaobserwowane trendy żywieniowe oraz brak wystarczających informacji w literaturze przedmiotu odnoszących się do stabilności przechowalniczej produktów bezlaktozowych były inspiracją do podjęcia badań dotyczących stabilności przechowalniczej bezlaktozowego sera twarogowego kwasowego. Celem pracy była ocena wybranych cech jakościowych serów twarogowych kwasowych: tradycyjnego i bezlaktozowego, zakupionych w handlu detalicznym na terenie Szczecina i przechowywanych w warunkach chłodniczych (5 ± 1 ºC) bez dostępu światła przez 21 dni. W pracy założono, że twarogi pochodzące od tego samego produce

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Brodziak, A., J. Król, and M. Ryszkowska-Siwko. "Zawartość białka w różnych rodzajach serów dostępnych na rynku." Scientific Journal of Gdynia Maritime University, no. 104 (September 30, 2018): 25–35. http://dx.doi.org/10.26408/104.03.

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Celem pracy było oznaczenie zawartości białka ogólnego w wybranych serach podpuszczkowych dojrzewających i topionych oraz produktach seropodobnych dostępnych w sieci detalicznej Lublina. W badaniach łącznie uwzględniono 23 rodzaje serów wyprodukowanych z mleka krowiego, w tym 16 serów podpuszczkowych dojrzewających i 4 topione, a także 3 produkty seropodobne. W każdej próbce oznaczono zawartość białka przy użyciu metody Kjeldahla. Spośród wszystkich badanych serów sery topione stanowiły najuboższe źródło białka (od 8,07 do 9,06%), natomiast sery podpuszczkowe dojrzewające zawierały najwięcej

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Mulawka, Elżbieta, Izabela Dmytrów, Anna Mituniewicz-Małek, and Krzysztof Godula. "Rodzaj kultury starterowej a wybrane cechy fizykochemiczne sera twarogowego w czasie przechowywania." Zywnosc Nauka Technologia Jakosc/Food Science Technology Quality 118, no. 1 (2019): 95–110. http://dx.doi.org/10.15193/zntj/2019/118/276.

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Analizowano cechy fizykochemiczne, reologiczne (twardość) oraz sensoryczne serów twarogowych kwasowych z mleka krowiego z dodatkiem szczepionki MSO oraz MSO-11 podczas 21 dni chłodniczego przechowywania w temp. 5 ± 1 ºC. Wyprodukowane w warunkach laboratoryjnych próbki doświadczalne zapakowano próżniowo w folię PE/PA o grubości 40 µm. Analizę serów twarogowych wykonano bezpośrednio po wyprodukowaniu oraz po 3, 7, 14 i 21 dniach przechowywania w warunkach chłodniczych. Badane twarogi każdorazowo poddawano ocenie sensorycznej z zastosowaniem skali porządkowej – pięciopunktowej oraz oznaczono w n

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Brodziak, Aneta. "Sery z mleka krów ras lokalnych jako cenne źródło składników odżywczych*." PRZEMYSŁ SPOŻYWCZY 1, no. 5 (2019): 37–40. http://dx.doi.org/10.15199/65.2019.5.7.

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Kitay, A. G., G. A. Kropachev, and M. V. Klement'ev. "OBRAZOVANIE OTLOZhENIY ELEMENTNOY SERY V PROMYShLENNYKh GAZOKhODAKh PRI AVTOKLAVNOY PERERABOTKE SUL'FIDNYKh KONTsENTRATOV." Металлы, no. 1 (December 15, 2024): 11–23. http://dx.doi.org/10.31857/s0869573324011123.

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Oates, John F., Neal Woodman, Philippe Gaubert, et al. "A new species of tree hyrax (Procaviidae: Dendrohyrax) from West Africa and the significance of the Niger-Volta interfluvium in mammalian biogeography." Zoological Journal of the Linnean Society 194, no. 2 (2022): 527–52. https://doi.org/10.1093/zoolinnean/zlab029.

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Oates, John F, Woodman, Neal, Gaubert, Philippe, Sargis, Eric J, Wiafe, Edward D, Lecompte, Emilie, Dowsett-Lemaire, Françoise, Dowsett, Robert J, Gonedelé Bi, Sery, Ikemeh, Rachel A, Djagoun, Chabi A M S, Tomsett, Louise, Bearder, Simon K (2022): A new species of tree hyrax (Procaviidae: Dendrohyrax) from West Africa and the significance of the Niger-Volta interfluvium in mammalian biogeography. Zoological Journal of the Linnean Society 194 (2): 527-552, DOI: 10.1093/zoolinnean/zlab029, URL: https://academic.oup.com/zoolinnean/article/194/2/527/6299316

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Ricaurte, Carlos Jesús Molina. "Análisis crítico del tema de la violencia en La vorágine de José Eustasio Rivera." Civilizar 14, no. 27 (2014): 203. http://dx.doi.org/10.22518/16578953.190.

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La vorágine es una novela insigne de la literatura colombiana e hispanoamericanaque trata de manera singular el tema de la violencia. Este artículo proponeuna reflexión filosófica novedosa para abordar la violencia como objeto deconocimiento. Se plantea, en primer lugar, un nuevo enfoque a partir de lateoría literaria, enseguida se consideran aspectos del relato, tales como: la doblenaturaleza del mundo, el absurdo y la dinámica autoproductiva de la violencia ycon ayuda de varios autores, constatamos cómo estos mismos aspectos admitennuevas aproximaciones. Este artículo nos lleva a pensar nuev

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Malczyk, Ewa, Agnieszka Malczyk, and Anna Krawczyk. "Eating behaviours of a group of Polish people living in Poland and the United Kingdom." Bromatologia i Chemia Toksykologiczna LIV, no. 2 (2022): 75–92. http://dx.doi.org/10.32383/bct/154660.

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Wprowadzenie. Zjawisko emigracji jest złożone, dla emigrantów jest doświadczeniem osobistym i emocjonalnym, a więc – subiektywnym. Życie na emigracji często różni się, a wielokrotnie w znacznym stopniu, od życia w ojczystym kraju, wiąże się z koniecznością osiedlenia w nowych, najczęściej odmiennych warunkach bytowych, społecznych i kulturowych. Większość emigrantów stopniowo zmienia swój sposób żywienia przyjmując zasady żywienia kraju gospodarza. Jednak zawsze powinno się pamiętać o prawidłowych zachowaniach żywieniowych, które wsparte aktywnością fizyczną są najskuteczniejszym sposobem zapo

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Mayer, Andreas, Martin Heidemann, Michael Lidschreiber, et al. "CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II." Science 336, no. 6089 (2012): 1723–25. http://dx.doi.org/10.1126/science.1219651.

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In different phases of the transcription cycle, RNA polymerase (Pol) II recruits various factors via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. We show that the CTD of transcribing yeast Pol II is phosphorylated at Tyr1, in addition to Ser2, Thr4, Ser5, and Ser7. Tyr1 phosphorylation stimulates binding of elongation factor Spt6 and impairs recruitment of termination factors Nrd1, Pcf11, and Rtt103. Tyr1 phosphorylation levels rise downstream of the transcription start site and decrease before the polyadeny

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Araos San Martín, Jaime. ""Tomás de Aquino y el concepto tradicional de la verdad, según Ser y tiempo, §44"." Anales del Seminario de Historia de la Filosofía 36, no. 2 (2019): 477–93. http://dx.doi.org/10.5209/ashf.64455.

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El objetivo de este estudio es examinar hasta qué punto es válido incluir el pensamiento deTomás de Aquino, junto al de Aristóteles y Kant, en la estructura filosófica que Heidegger llama, en Sery tiempo § 44, “concepto tradicional de la verdad” (traditionellen Wahrheitsbegriff). Partiendo de ladefinición de la verdad como adecuación del intelecto y la cosa, se somete a discusión la equivalenciaentre el concepto aristotélico de ὁμοίωσις, el tomista de adaequatio y el kantiano de Übereinstimmung.Para ello se examina detenidamente la noción de adaequatio, se la distingue de otras nociones cercan

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Bitaraf, Mehrnoosh, and Ali Amoozadeh. "A novel sery of SO3H-functionalized heterostructure nano-semiconductors; an efficient strategy to prepare visible-light responsive photocatalysts." Research on Chemical Intermediates 47, no. 8 (2021): 3329–47. http://dx.doi.org/10.1007/s11164-021-04458-y.

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Wilk, Gabriela. "„Вторая” жизнь советских комедий в интернет-мемах периода пандемии". Studia Rossica Posnaniensia 47, № 1 (2022): 243–60. http://dx.doi.org/10.14746/strp.2022.47.1.16.

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Nowadays, it is hard to imagine internet culture without memes. To achieve a humorous effect, meme creators use various means, displaying unprecedented creativity. They often draw inspiration from cult Soviet comedies by Leonid Gaidai, Georgiy Daneliya, Vladimir Menshov, Eldar Ryazanov, Aleksandr Sery and other famous directors. This article is devoted to the analysis of iintertextual connections in Russian internet memes related to the current COVID-19 pandemic. The intertextual references can be in the form of a frame from a Soviet comedy, a movie catchphrase, or both at the same time. Catch

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Halicka, Ewa, and Aneta Woźniak. "The Level and Differentiation of Food Consumption in the Mazowsze Region." Wieś i Rolnictwo, no. 2 (147) (June 20, 2010): 189–98. http://dx.doi.org/10.53098/wir.2010.2.147/12.

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Artykuł przedstawia analizę i ocenę spożycia żywności w województwie mazowieckim na podstawie danych z reprezentatywnych badań budżetów domowych GUS. Konsumpcję podstawowych grup artykułów żywnościowych porównano w ujęciu województwo/kraj oraz wieś/miasto/Warszawa. Opracowane informacje statystyczne z 2006 roku wskazują, że gospodarstwa domowe województwa mazowieckiego charakteryzują się wyższą, od średniej w Polsce, konsumpcją tzw. dóbr wyższego rzędu, tj. relatywnie droższych produktów spożywczych, o większym wskaźniku elastyczności dochodowej popytu. Według zebranych danych budżetowych, poz

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Mandić, Dragan, Novo Pržulj, Goran Đurašinović, and Zoran Jovović. "Julija: New variety of wheat." Selekcija i semenarstvo 26, no. 2 (2020): 15–20. http://dx.doi.org/10.5937/selsem2002015m.

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Julija is a high-yielding, medium-early, quality variety of winter wheat, created by the method of hybridization of two genetically divergent parents, homozygous lines Sery 13/2, and BL 24/38. In the genetic structure of this variety, the genes responsible for high genetic potential of fertility, very good technological quality, early maturity, low winter hardiness, excellent resistance to lodging, low temperatures and diseases have been successfully combined. It was recognized and registered by the Commission for the Recognition of Varieties of the Republic of Serbia in 2020. It has wide adap

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Egloff, Sylvain, and Shona Murphy. "Role of the C-terminal domain of RNA polymerase II in expression of small nuclear RNA genes." Biochemical Society Transactions 36, no. 3 (2008): 537–39. http://dx.doi.org/10.1042/bst0360537.

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Pol II (RNA polymerase II) transcribes the genes encoding proteins and non-coding snRNAs (small nuclear RNAs). The largest subunit of Pol II contains a distinctive CTD (C-terminal domain) comprising a repetitive heptad amino acid sequence, Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. This domain is now known to play a major role in the processes of transcription and co-transcriptional RNA processing in expression of both snRNA and protein-coding genes. The heptapeptide repeat unit can be extensively modified in vivo and covalent modifications of the CTD during the transcription cycle result in the orde

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De Vriese, Carine, Francoise Gregoire, Roger Lema-Kisoka, Magali Waelbroeck, Patrick Robberecht, and Christine Delporte. "Ghrelin Degradation by Serum and Tissue Homogenates: Identification of the Cleavage Sites." Endocrinology 145, no. 11 (2004): 4997–5005. http://dx.doi.org/10.1210/en.2004-0569.

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Abstract The endogenous ligand for the GH secretagogue receptor is ghrelin, a peptide recently purified from the stomach. Ghrelin is n-octanoylated on the Ser3 residue, and this modification is essential for its interaction with the receptor. The degradation of ghrelin by rat and human serum, purified commercial enzymes, and tissues homogenates was analyzed by combining HPLC and mass spectrometry. In serum, ghrelin was desoctanoylated, without proteolysis. The desoctanoylation was significantly reduced by phenylmethylsulfonyl fluoride, a serine proteases and esterases inhibitor. In rat serum,

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Peters-Wendisch, Petra, Michael Stolz, Helga Etterich, Nicole Kennerknecht, Hermann Sahm, and Lothar Eggeling. "Metabolic Engineering of Corynebacterium glutamicum for l-Serine Production." Applied and Environmental Microbiology 71, no. 11 (2005): 7139–44. http://dx.doi.org/10.1128/aem.71.11.7139-7144.2005.

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ABSTRACT Although l-serine proceeds in just three steps from the glycolytic intermediate 3-phosphoglycerate, and as much as 8% of the carbon assimilated from glucose is directed via l-serine formation, previous attempts to obtain a strain producing l-serine from glucose have not been successful. We functionally identified the genes serC and serB from Corynebacterium glutamicum, coding for phosphoserine aminotransferase and phosphoserine phosphatase, respectively. The overexpression of these genes, together with the third biosynthetic serA gene, serA Δ 197, encoding an l-serine-insensitive 3-ph

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Picotti, Dina. "Los aportes de una antropología americana en el pensamiento de Rodolfo Kusch." Análisis, no. 77 (December 15, 2010): 89. http://dx.doi.org/10.15332/s0120-8454.2010.0077.04.

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<p>El presente texto versa sobre la propuesta de Rodolfo Kusch en torno a una <br />antropología del hombre americano a partir de un recorrido por algunas obras insignes de su pensamiento antropológico. El trabajo parte de la problematización de la categoría de situación. A partir de ciertas distinciones filosóficas establecidas entre sery estar, la autora aborda la cuestión de la identidad americana como pueblo, para indicar la manera en que el habla popular, en su nombrar y callar, es la base de lo que pueda ser el hombre americano. Después de la descripción de la consolidación d

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Hempen, Eric, Bennet Butler, Muturi Muriuki, and Anish Kadakia. "A Biomechanical Analysis of Ankle Instability in Supination External Rotation Ankle Fractures." Foot & Ankle Orthopaedics 3, no. 3 (2018): 2473011418S0006. http://dx.doi.org/10.1177/2473011418s00062.

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Category: Trauma Introduction/Purpose: Supination external rotation (SER) 2 and SER3 ankle injuries are thought to be stable whereas SER4 injuries are thought to be unstable. In other words, deltoid rupture is thought to be a necessary component of instability in SER injuries. However, biomechanical evidence has shown that as little as 1 mm talar shift results in 40% loss in contact area leading to increased contact forces. Additionally, the external rotation stress exam which is the typical test used to detect instability is poorly standardized in the literature limiting its ability to detect

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Zuba-Ciszewska, Maria. "Rola spółdzielni w zapewnieniu dostępności żywności w Polsce − na przykładzie produktów mleczarskich." Wieś i Rolnictwo, no. 1 (186) (January 20, 2020): 93–119. http://dx.doi.org/10.53098/wir012020/05.

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W artykule dokonano oceny bezpieczeństwa żywnościowego produktów mleczarskich w Polsce w najważniejszym jej wymiarze, tj. dostępności żywności. Dominującą rolę w przetwórstwie mleka w Polsce zajmują spółdzielnie mleczarskie. Stanowią 62% wszystkich mleczarni w kraju, mając udział w skupie mleka na poziomie 72%. Dlatego nowym ujęciem w powyższych rozważaniach jest uwzględnienie roli spółdzielni. Zakres czasowy pracy obejmuje okres po transformacji gospodarki, a szczegółowe dane o asortymencie badanych mleczarni lata 2013 i 2017, ze względu na dostęp do porównywalnych danych z raportów mleczarsk

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Hamel, P. A., R. M. Gill, R. A. Phillips, and B. L. Gallie. "Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene." Molecular and Cellular Biology 12, no. 8 (1992): 3431–38. http://dx.doi.org/10.1128/mcb.12.8.3431-3438.1992.

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The protein product of the retinoblastoma susceptibility gene, p110RB1, is a nuclear phosphoprotein [W.H. Lee, J.Y. Shew, F.D. Hong, T.W. Sery, L.A. Donoso, L.J. Young, R. Bookstein, and E.Y. Lee, Nature (London) 329:642-645, 1987] with properties of a cell cycle regulator (K. Buchkovich, L.A. Duffy, and E. Harlow, Cell 58:1097-1105, 1989; P.L. Chen, P. Scully, J.Y. Shew, J.Y. Wang, and W.H. Lee, Cell 58:1193-1198, 1989; J.A. DeCaprio, J.W. Ludlow, D. Lynch, Y. Furukawa, J. Griffin, H. Piwnica-Worms, C.M. Huang, and D.M. Livingston, Cell 58:1085-1095, 1989; and K. Mihara, X.R. Cao, A. Yen, S.

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Hamel, P. A., R. M. Gill, R. A. Phillips, and B. L. Gallie. "Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene." Molecular and Cellular Biology 12, no. 8 (1992): 3431–38. http://dx.doi.org/10.1128/mcb.12.8.3431.

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The protein product of the retinoblastoma susceptibility gene, p110RB1, is a nuclear phosphoprotein [W.H. Lee, J.Y. Shew, F.D. Hong, T.W. Sery, L.A. Donoso, L.J. Young, R. Bookstein, and E.Y. Lee, Nature (London) 329:642-645, 1987] with properties of a cell cycle regulator (K. Buchkovich, L.A. Duffy, and E. Harlow, Cell 58:1097-1105, 1989; P.L. Chen, P. Scully, J.Y. Shew, J.Y. Wang, and W.H. Lee, Cell 58:1193-1198, 1989; J.A. DeCaprio, J.W. Ludlow, D. Lynch, Y. Furukawa, J. Griffin, H. Piwnica-Worms, C.M. Huang, and D.M. Livingston, Cell 58:1085-1095, 1989; and K. Mihara, X.R. Cao, A. Yen, S.

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LESCANO DIB, DANIELA. "RECONSTRUCCIÓN DEL QUEHACER PROFESIONAL DEL/A PSICÓLOGO/A FORENSE DEL PODER JUDICIAL DE SANTIAGO DEL ESTERO DESDE LA NARRATIVA DE SUS ACTORES (1987-2022)." Investigando en Psicología 1, no. 25 (2024): 83–98. http://dx.doi.org/10.70198/iep.v1i25.244.

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El presente trabajo surge de la tesis doctoral en psicología (UNT). Tienecomo objetivos la reconstrucción del quehacer profesional del/a psicólogo/aforense en el poder judicial de Santiago del Estero (1987-2022), desde lanarrativa de sus protagonistas y la historización del ingreso de la psicologíaforense en un contexto histórico, político, social e institucional.La metodología utilizada es cualitativa y consta de 3 etapas:Recolección de Información; Análisis de Información y Reconstrucción yTransformación del Quehacer profesional. Las técnicas de recolección dedatos son: entrevista semiestruc

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Liu, Shengqin, Brendan M. Byrne, Thomas N. Byrne, and Gregory G. Oakley. "Role of RPA Phosphorylation in the ATR-Dependent G2 Cell Cycle Checkpoint." Genes 14, no. 12 (2023): 2205. http://dx.doi.org/10.3390/genes14122205.

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Cells respond to DNA double-strand breaks by initiating DSB repair and ensuring a cell cycle checkpoint. The primary responder to DSB repair is non-homologous end joining, which is an error-prone repair pathway. However, when DSBs are generated after DNA replication in the G2 phase of the cell cycle, a second DSB repair pathway, homologous recombination, can come into action. Both ATM and ATR are important for DSB-induced DSB repair and checkpoint responses. One method of ATM and ATR working together is through the DNA end resection of DSBs. As a readout and marker of DNA end resection, RPA is

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Yamakawa, Hiroko, Akio Mizutani, Yasuyoshi Arikawa, Shunsuke Ebara, Yoshihiko Satoh, and Daisuke Morishita. "Abstract 5485: Discovery and preclinical evaluation of a novel highly selective and potent CDK12 inhibitor." Cancer Research 82, no. 12_Supplement (2022): 5485. http://dx.doi.org/10.1158/1538-7445.am2022-5485.

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Abstract Recent research highlights that RNA processing is systematically altered in cancer, demonstrating the pivotal influence of RNA deregulation on tumorigenesis, growth and progression. Based on our expanding knowledge of RNA biology, RNA deregulation has drawn much attention from the perspective of cancer therapy. Indeed, small molecules that attack the RNA maturation processes and produce aberrant RNA are currently under development. The first step in gene expression is transcription, which involves copying a DNA sequence to make an RNA. Transcription is performed by enzymes called RNA

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Hemeda, O. M., A. Tawfik, D. M. Hemeda, and A. M. Elsheekh. "Preparation and electrical properties of Ni–Cu–Zn system doped with the magnesium oxide." International Journal of Modern Physics B 28, no. 23 (2014): 1450157. http://dx.doi.org/10.1142/s0217979214501574.

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A sery of ferrite samples, Ni 0.1 Cu 0.2 Mg x Zn 0.7-x Fe 2 O 4, (x = 0.00, 0.15, 0.25, 0.35, 0.45, 0.55 and 0.70) have been prepared by the standard ceramic techniques, sintered at 1200°C for 2 h, and their crystalline structures were investigated by using X-ray diffraction, which confirmed the formation of Ni 0.1 Cu 0.2 Mg x Zn 0.7-x Fe 2 O 4 phase. The presence of Mg content increases the crystallinity of the given ferrite which is considered as catalyst for the accomplishment of the solid state reaction. The lattice parameter and crystallite size were calculated from XRD. The cationic dist

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Yun, Y., and R. L. Davis. "Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP." Molecular and Cellular Biology 9, no. 2 (1989): 692–700. http://dx.doi.org/10.1128/mcb.9.2.692-700.1989.

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We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster. These mutants have an elevated cyclic AMP (cAMP) content due to a mutation in the structural gene for cAMP phosphodiesterase, so the isolated genes are potentially ones regulated by cAMP. Here, we describe the characterization of a genomic clone and corresponding cDNA clones which contain sequences that are underexpressed in dnc mutants. Sequence analysis of portions of the genomic clone and representative cDNAs revealed the presence of two uninterrupted and complete open

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Yun, Y., and R. L. Davis. "Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP." Molecular and Cellular Biology 9, no. 2 (1989): 692–700. http://dx.doi.org/10.1128/mcb.9.2.692.

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We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster. These mutants have an elevated cyclic AMP (cAMP) content due to a mutation in the structural gene for cAMP phosphodiesterase, so the isolated genes are potentially ones regulated by cAMP. Here, we describe the characterization of a genomic clone and corresponding cDNA clones which contain sequences that are underexpressed in dnc mutants. Sequence analysis of portions of the genomic clone and representative cDNAs revealed the presence of two uninterrupted and complete open

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Komatsu, Satoshi, and Mitsuo Ikebe. "The Phosphorylation of Myosin II at the Ser1 and Ser2 Is Critical for Normal Platelet-derived Growth Factor–induced Reorganization of Myosin Filaments." Molecular Biology of the Cell 18, no. 12 (2007): 5081–90. http://dx.doi.org/10.1091/mbc.e06-12-1076.

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Phosphorylation of the regulatory light chain of myosin II (MLC20) at the activation sites promotes both the motor activity and the filament formation of myosin II, thus playing an important role in various cell motile processes. In contrast, the physiological function of phosphorylation of MLC20 at the inhibitory sites is unknown. Here we report for the first time the function of the inhibitory site phosphorylation in the cells. We successfully produced the antibodies specifically recognizing the phosphorylation sites of MLC20 at Ser1, and the platelet-derived growth factor (PDGF)-induced cha

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Ahmed, Wasa Alibe, Iliya Lorine, and Ishaku Lemu Haruna. "Incidence of HIV among Pregnant Women Attending Ante-Natal Clinic in General Hospital Kaltungo, Gombe State, Nigeria." Greener Journal of Microbiology and Antimicrobials 2, no. 3 (2014): 59–63. https://doi.org/10.15580/gjma.2014.3.022114121.

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Sero-prevalence diagnosis of HIV among six hundred and ninety- one (691) pregnant women attending ante-natal Clinic in General Hospital Kaltungo was carried out from the month of December, 2011 to May, 2012. Blood samples obtained from pregnant women of different age groups, social and economic status were screened using Abbott determine rapid test strip. Out of the 691 sera collected, 65 (9.4%) were HIV sero-positive. The prevalence rate was 15 in 15-24 years age group, 45 in 25-34 age group and 5 in 35 years and above. This result indicates highest incidence rate among age group 25-35 y

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Jhaveri, K. "Abstract TF1-2: ER+ word salad decoded: SERD, SERM, SERCA, CERAN, PROTAC." Cancer Research 82, no. 4_Supplement (2022): TF1–2—TF1–2. http://dx.doi.org/10.1158/1538-7445.sabcs21-tf1-2.

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Abstract Estrogen receptor (ER) plays an important role in gene transcription and the proliferation of ER positive (ER+) breast cancers. Selective estrogen receptor modulators (SERMs), aromatase inhibitors (AIs) and fulvestrant, a selective estrogen receptor degrader (SERD) are currently approved therapeutic approaches for ER positive breast cancers. While these treatment strategies are highly effective, de novo and secondary resistance remains a challenge. Despite resistance mechanisms including due to mutations in the ligand binding domain of the ERα gene (ESR1 mutations), ER+ breast cancers

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Zhang, Bo, Xuelin Zhong, Moira Sauane, Yihong Zhao, and Zhi-Liang Zheng. "Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy." Cells 9, no. 3 (2020): 621. http://dx.doi.org/10.3390/cells9030621.

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Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown that plant ROP and yeast Cdc42 GTPases similarly modulate Ser2 and Ser5 phosphorylation status of the C-terminal domain (CTD) of the Pol II largest subunit by regulating CTD phosphatase degradation. Here, we present genetic and pharmacological evidence showing that Cdc42 and Rac1 GTPase signaling modulates a similar CTD Ser2 and Ser5 phosphorylation code in cultured human cancer cells. While siRNA knockdown of Cdc42 and Rac1, re

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Tellier, Michael, Justyna Zaborowska, Livia Caizzi, et al. "CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation." Nucleic Acids Research 48, no. 14 (2020): 7712–27. http://dx.doi.org/10.1093/nar/gkaa514.

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Abstract Cyclin-dependent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) but its roles in transcription beyond the expression of DNA damage response genes remain unclear. Here, we have used TT-seq and mNET-seq to monitor the direct effects of rapid CDK12 inhibition on transcription activity and CTD phosphorylation in human cells. CDK12 inhibition causes a genome-wide defect in transcription elongation and a global reduction of CTD Ser2 and Ser5 phosphorylation. The elongation defect is explained by the loss of the elongation factors LEO1 and C

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Ovchinnikov, Mikhail V., Zhanna D. Bespalova, Aleksandr S. Molokoedov та ін. "Atriopeptins. III. Synthesis and biological activity studies of α-r-ANF, AP-II, AP-III and des-Ser5-Ser6-AP-II". Collection of Czechoslovak Chemical Communications 54, № 3 (1989): 796–802. http://dx.doi.org/10.1135/cccc19890796.

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Starting from previously synthesized atriopeptin fragments, peptides α-r-ANF, AP-II, AP-III and des-Ser5-Ser6-AP-II were prepared using complex F. The acetamidomethyl protecting group on cysteine was removed simultaneously with the cyclization. Biological activity of atriopeptin was evaluated.

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Tellier, Michael, Gilbert Ansa, and Shona Murphy. "Isoginkgetin and Madrasin are poor splicing inhibitors." PLOS ONE 19, no. 10 (2024): e0310519. http://dx.doi.org/10.1371/journal.pone.0310519.

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The production of eukaryotic mRNAs requires transcription by RNA polymerase (pol) II and co-transcriptional processing, including capping, splicing, and cleavage and polyadenylation. Pol II can positively affect co-transcriptional processing through interaction of factors with its carboxyl terminal domain (CTD), comprising 52 repeats of the heptapeptide Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7, and pol II elongation rate can regulate splicing. Splicing, in turn, can also affect transcriptional activity and transcription elongation defects are caused by some splicing inhibitors. Multiple small molecu

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Egloff, Sylvain, Justyna Zaborowska, Clélia Laitem, Tamás Kiss, and Shona Murphy. "Ser7 Phosphorylation of the CTD Recruits the RPAP2 Ser5 Phosphatase to snRNA Genes." Molecular Cell 45, no. 1 (2012): 111–22. http://dx.doi.org/10.1016/j.molcel.2011.11.006.

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SOUZA, Cibele Naidhig de. "O DESENVOLVIMENTO DA EXPRESSÃO MODALIZADORA “PODE SER”. UM CASO DE (INTER)SUBJETIVIZAÇÃO NO PORTUGUÊS." Alfa : Revista de Linguística (São José do Rio Preto) 59, no. 1 (2015): 29–58. http://dx.doi.org/10.1590/1981-5794-1502-2.

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Comprometido com um enfoque funcionalista, o trabalho analisa a expressão modalizadora pode ser como predicado encaixador de proposição (pode ser1) e como construção independente (pode ser2), em textos contemporâneos do português brasileiro, de fala e de escrita. Busca-se identificar graus de (inter)subjetividade reveladores de um processo de (inter)subjetivização, conforme proposta de Traugott (2010). Sustentam a análise parâmetros de (inter)subjetividade de elementos modalizadores indicados especialmente em Traugott e Dasher (2002) e a noção de modalidade como categoria multifuncional, que n

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Boehm, Amber K., Abbie Saunders, Janis Werner, and John T. Lis. "Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat Shock." Molecular and Cellular Biology 23, no. 21 (2003): 7628–37. http://dx.doi.org/10.1128/mcb.23.21.7628-7637.2003.

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ABSTRACT The uninduced Drosophila hsp70 gene is poised for rapid activation. Here we examine the rapid changes upon heat shock in levels and location of heat shock factor (HSF), RNA polymerase II (Pol II) and its phosphorylated forms, and the Pol II kinase P-TEFb on hsp70 in vivo by using both real-time PCR assays of chromatin immunoprecipitates and polytene chromosome immunofluorescence. These studies capture Pol II recruitment and progression along hsp70 and reveal distinct spatial and temporal patterns of serine 2 and serine 5 phosphorylation: in uninduced cells, the promoter-paused Pol II

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Raghunath, Gokul, Yen-Cheng Chen, Mariana Marin, Hui Wu, and Gregory B. Melikyan. "SERINC5-Mediated Restriction of HIV-1 Infectivity Correlates with Resistance to Cholesterol Extraction but Not with Lipid Order of Viral Membrane." Viruses 14, no. 8 (2022): 1636. http://dx.doi.org/10.3390/v14081636.

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Serine incorporator 5 (SER5) is a protein that upon incorporation into virions inhibits HIV-1 infectivity by interfering with the ability of the Env glycoprotein to promote viral fusion. The mechanisms by which SER5 antagonizes HIV-1 fusion are not well understood. A recent study of SER5’s structure revealed a lipid-binding pocket, suggesting the ability to sequester lipids. This finding, along with the well-documented modulation of HIV-1 infectivity by viral lipids, especially cholesterol, prompted our examination of SER5′s effect on the general lipid order of the HIV-1 membrane. Pseudoviruse

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Raghunath, Gokul, Elizabeth H. Abbott, Mariana Marin, et al. "Disruption of Transmembrane Phosphatidylserine Asymmetry by HIV-1 Incorporated SERINC5 Is Not Responsible for Virus Restriction." Biomolecules 14, no. 5 (2024): 570. http://dx.doi.org/10.3390/biom14050570.

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Host restriction factor SERINC5 (SER5) incorporates into the HIV-1 membrane and inhibits infectivity by a poorly understood mechanism. Recently, SER5 was found to exhibit scramblase-like activity leading to the externalization of phosphatidylserine (PS) on the viral surface, which has been proposed to be responsible for SER5’s antiviral activity. This and other reports that document modulation of HIV-1 infectivity by viral lipid composition prompted us to investigate the role of PS in regulating SER5-mediated HIV-1 restriction. First, we show that the level of SER5 incorporation into virions c

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Krishnamurthy, Shankarling, Mohamed A. Ghazy, Claire Moore, and Michael Hampsey. "Functional Interaction of the Ess1 Prolyl Isomerase with Components of the RNA Polymerase II Initiation and Termination Machineries." Molecular and Cellular Biology 29, no. 11 (2009): 2925–34. http://dx.doi.org/10.1128/mcb.01655-08.

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ABSTRACT The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a reiterated heptad sequence (Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7) that plays a key role in the transcription cycle, coordinating the exchange of transcription and RNA processing factors. The structure of the CTD is flexible and undergoes conformational changes in response to serine phosphorylation and proline isomerization. Here we report that the Ess1 peptidyl prolyl isomerase functionally interacts with the transcription initiation factor TFIIB and with the Ssu72 CTD phosphatase and Pta1 components o

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Mulligan, Michael P., Matthew W. Boudreau, David J. Shapiro, et al. "Abstract 522: Selective estrogen receptor a-UPR activators (SERA): a novel class of small molecules that eradicate estrogen receptor positive tumors." Cancer Research 83, no. 7_Supplement (2023): 522. http://dx.doi.org/10.1158/1538-7445.am2023-522.

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Abstract While therapy of estrogen receptor alpha positive (ERα+) breast cancer is often initially successful with ERα modulating or inhibiting drugs, eventual drug resistance is universal and such treatments are rarely curative. To address this considerable medical need, several generations of novel anti-tumor small molecule agents specifically targeting the estrogen-ERα interaction have been synthesized and characterized. We are pursuing an alternative approach, activation of an endogenous cell death pathway downstream of ERα with non-competitive Selective Estrogen Receptor Activators (SERAs

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Schwer, Beate, Ana M. Sanchez, and Stewart Shuman. "RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast." RNA 21, no. 10 (2015): 1770–80. http://dx.doi.org/10.1261/rna.052555.115.

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Singla, Bhumica, Jitendra P. Khurana, and Paramjit Khurana. "Structural Characterization and Expression Analysis of the SERK/SERL Gene Family in Rice (Oryza sativa)." International Journal of Plant Genomics 2009 (September 13, 2009): 1–8. http://dx.doi.org/10.1155/2009/539402.

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Somatic embryogenesis (SE) is the developmental restructuring of somatic cells towards the embryogenic pathway and forms the basis of cellular totipotency in angiosperms. With the availability of full-length cDNA sequences from Knowledge-based Oryza Molecular Biological Encylopedia (KOME), we identified the leucine-rich repeat receptor-like kinase (LRR-RLK) genes from rice (Oryza sativa), which also encompasses genes involved in regulating somatic embryogenesis. Eight out of eleven of the rice SERK and SERL (SERK-like) genes have the TIGR annotation as (putative) brassinosteroid insensitive 1-

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Bherer, Juliette, Alisson Clemenceau, Caroline Diorio, and Francine Durocher. "Abstract 1587: Breast cancer treatment: Exploring bazedoxifene, a known SERM, SERD and indirect STAT3 inhibitor." Cancer Research 83, no. 7_Supplement (2023): 1587. http://dx.doi.org/10.1158/1538-7445.am2023-1587.

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Abstract In 2020, breast cancer was the most widespread cancer. This heterogenous disease can be divided into molecular subtypes according to three biomarkers: Estrogen Receptor (ER), Progesterone Receptor (PR) and Epidermal Growth Factor Receptor 2 (HER2). Currently, triple-negative breast cancers (TNBC), negative for all three biomarkers, have no personalized treatment. Also, about 40% of women with breast cancer receiving tamoxifen, a selective estrogen receptor modulator (SERM), have or will develop a resistance. Bazedoxifene (BZA), a SERM, a selective estrogen receptor modulator (SERD) an

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Mazina, Marina Yu, Elena V. Kovalenko, Aleksandra A. Evdokimova, Maksim Erokhin, Darya Chetverina, and Nadezhda E. Vorobyeva. "RNA Polymerase II “Pause” Prepares Promoters for Upcoming Transcription during Drosophila Development." International Journal of Molecular Sciences 23, no. 18 (2022): 10662. http://dx.doi.org/10.3390/ijms231810662.

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According to previous studies, during Drosophila embryogenesis, the recruitment of RNA polymerase II precedes active gene transcription. This work is aimed at exploring whether this mechanism is used during Drosophila metamorphosis. In addition, the composition of the RNA polymerase II “paused” complexes associated with promoters at different developmental stages are described in detail. For this purpose, we performed ChIP-Seq analysis using antibodies for various modifications of RNA polymerase II (total, Pol II CTD Ser5P, and Pol II CTD Ser2P) as well as for subunits of the NELF, DSIF, and P

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