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Dissertations / Theses on the topic 'Sliced model'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Momotenko, Ruslana, Artem Terzi, and Yuryi Vlasenko. "Preparation of geometric data for 3D prototyping." Thesis, National aviation university, 2021. https://er.nau.edu.ua/handle/NAU/52827.

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1. Kasik D.J., Buxton W., Ferguson D.R. Ten cad challenges // IEEE Computer Graphics and Applications. 2005. (25). C. 81–92. 2. NURBS-based and parametric-based shape optimization with differentiated CAD kernel // Computer-Aided Design and Applications. 2018. № 6 (15). 3. STL, 3D Manufacturing Format, and Additive Manufacturing File Export Options [Electronic resource]. - Access mode: http://help.solidworks.com/2018/english/SolidWorks/ sldworks/HIDD_STL.htm<br>Despite the presence of high-tech CAD/CAM/CAE-systems, the problem of exchanging engineering data, primarily the structural elements

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2

Rambani, Komal. "Thick brain slice cultures and a custom-fabricated multiphoton imaging system: progress towards development of a 3D hybrot model." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22702.

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Development of a three dimensional (3D) HYBROT model with targeted in vivo like intact cellular circuitry in thick brain slices for multi-site stimulation and recording will provide a useful in vitro model to study neuronal dynamics at network level. In order to make this in vitro model feasible, we need to develop several associated technologies. These technologies include development of a thick organotypic brain slice culturing method, a three dimensional (3D) micro-fluidic multielectrode Neural Interface system (ÂµNIS) and the associated electronic interfaces for stimulation and recording

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3

Scott, Maya Millicent. "Canine hepatic slices as a model for studying drug toxicity and metabolism." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/3731.

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Tissue slices can be made from organs, such as liver, kidney, brain, and heart, and from various species including humans, dogs, non-human primates, rats and mice. It has been demonstrated that human and rat liver slices are viable for up to 2 days, and liver slices have been extensively used as an in vitro method to study hepatic drug metabolism and toxicity in humans. The objective of this study was to determine the utility of canine hepatic slices as an in vitro model for studying drug metabolism and hepatotoxicity in dogs. Canine hepatic slices were incubated in media containing various dr

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Kiss, Andrew Elek, and Andrew Kiss@anu edu au. "Dynamics of laboratory models of the wind-driven ocean circulation." The Australian National University. Research School of Earth Sciences, 2001. http://thesis.anu.edu.au./public/adt-ANU20011018.115707.

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This thesis presents a numerical exploration of the dynamics governing rotating flow driven by a surface stress in the " sliced cylinder " model of Pedlosky & Greenspan (1967) and Beardsley (1969), and its close relative, the " sliced cone " model introduced by Griffiths & Veronis (1997). The sliced cylinder model simulates the barotropic wind-driven circulation in a circular basin with vertical sidewalls, using a depth gradient to mimic the effects of a gradient in Coriolis parameter. In the sliced cone the vertical sidewalls are replaced by an azimuthally uniform slope around the

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5

Wolkerstorfer, William J. "A linear maneuvering model for simulation of SLICE hulls." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1995. http://handle.dtic.mil/100.2/ADA304356.

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6

Stevens, Henry William. "Resistance scaling and predictions of SLICE hulls from model tests." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1995. http://handle.dtic.mil/100.2/ADA304547.

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7

McGuckin, C. E. "The mathematical modelling of diffusion techniques associated with osmotic dehydration of apple slices." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329361.

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8

Chalupa, Daniel. "Rozšiřující modul platformy 3D Slicer pro segmentaci tomografických obrazů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316852.

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This work explores machine learning as a tool for medical images' classification. A literary research is contained concerning both classical and modern approaches to image segmentation. The main purpose of this work is to design and implement an extension for the 3D Slicer platform. The extension uses machine learning to classify images using set parameters. The extension is tested on tomographic images obtained by nuclear magnetic resonance and observes the accuracy of the classification and usability in practice.

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9

Purvis, Liston Keith. "Models of Single Neurons and Network Dynamics in the Medullary Transverse Slice." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14125.

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The pre-Botzinger complex (pBC) is a sub-circuit of the respiratory central pattern generator. The pBC is required for eupnea and is contained in a transverse slice of the ventrolateral medulla. In the slice, pBC cells are responsible for generating the respiratory rhythm, and hypoglossal motoneurons (HMs) are responsible for transmitting the rhythm out of the brainstem to the muscles. Understanding how the transverse slice rhythm is generated and transmitted is a first step in understanding how this process occurs in vivo. To understand this network, we developed ionic current models of t

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10

Bussek, Alexandra, Erich Wettwer, Torsten Christ, Horst Lohmann, Patrizia Camelliti, and Ursula Ravens. "Tissue Slices from Adult Mammalian Hearts as a Model for Pharmacological Drug Testing." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-137634.

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Aim: Isolated papillary muscles and enzymatically dissociated myocytes of guinea-pig hearts are routinely used for experimental cardiac research. The aim of our study is to investigate adult mammalian ventricular slices as an alternative preparation. Method: Vibratome cut ventricular slices (350 μm thick) were examined histologically and with 2-photon microscopy for fibre orientation. Intracellular action potentials were recorded with conventional glass microelectrodes, extracellular potentials were measured with tungsten platinum electrodes and multi-electrode arrays (MEA). Results: Dominant

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11

Bussek, Alexandra, Erich Wettwer, Torsten Christ, Horst Lohmann, Patrizia Camelliti, and Ursula Ravens. "Tissue Slices from Adult Mammalian Hearts as a Model for Pharmacological Drug Testing." Karger, 2009. https://tud.qucosa.de/id/qucosa%3A27744.

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Aim: Isolated papillary muscles and enzymatically dissociated myocytes of guinea-pig hearts are routinely used for experimental cardiac research. The aim of our study is to investigate adult mammalian ventricular slices as an alternative preparation. Method: Vibratome cut ventricular slices (350 μm thick) were examined histologically and with 2-photon microscopy for fibre orientation. Intracellular action potentials were recorded with conventional glass microelectrodes, extracellular potentials were measured with tungsten platinum electrodes and multi-electrode arrays (MEA). Results: Dominant

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12

Brant, Stephen. "Distribution of renal S100 proteins in physiological and pathological models." Thesis, University of East London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342101.

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13

Mohajer, Maryam. "Nonlinear time series analysis of electrical activity in a slice model of epilepsy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ46205.pdf.

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14

Shepherd, Timothy Michael. "Diffusion magnetic resonance imaging in a rat hippocampal slice model of acute brain injury." [Gainesville, Fla.]: University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000787.

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15

Johansson, Sara. "Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-541-0/.

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16

Fox, Jane. "Utility of the precision cut lung slice model to investigate airway smooth muscle contraction." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/30380/.

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Asthma is characterised by airway remodelling and an increase in airway resistance. A greater understanding of the mechanisms involved in airway inflammation and airway hyper-responsiveness (AHR) may highlight therapeutic opportunities for asthma. This study initially aimed to optimise the preparation of precision cut lung slices (PCLS) in mouse and pig to investigate the influence of calcium (Ca2+) homeostasis on airway smooth muscle (ASM) contraction as a prelude to human studies. The PCLS technique was then applied to a murine model of allergic airway disease to explore the inflammatory pro

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17

Croft, Cara Louise. "Investigating the mechanisms underlying Alzheimer's disease using a novel organotypic brain slice culture model." Thesis, King's College London (University of London), 2016. http://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-mechanisms-underlying-alzheimers-disease-using-a-novel-organotypic-brain-slice-culture-model(321a7046-c8e8-4c42-9abf-01792be7870c).html.

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Alzheimer's disease is a devastating progressive neurodegenerative disorder characterised by deposits of amyloid-β in extracellular plaques, intracellular neurofibrillary tangles comprising highly phosphorylated and aggregated tau species, synaptic dysfunction and neuronal death. Although several transgenic mouse models of Alzheimer's disease have been developed, in vivo studies using transgenic mice are time- and cost- consuming, and it is imperative that more ethically sustainable alternatives, which allow faster translation to the clinic, are developed. This thesis aims to determine if orga

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Stefaniak, Mary Suzanne. "Development and validation of lung slices as an in vitro model for pulmonary toxicity studies." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185594.

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In light of the increasing emphasis on in vitro techniques for toxicologic research, a new model system was developed for preparation and short term maintenance of mammalian lung slice in dynamic organ culture. Viability of explanted tissue, characterized by a number of biochemical and histological parameters, was maintained for 5 days in culture. Validation as a toxicologic tool was accomplished by screening a series of classical toxicants (acrolein, nitrofurantoin, paraquat, cyclophosphamide, monocrotaline, bleomycin and amiodarone). Results indicated this in vitro model system can be used t

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19

Neda, Milić. "Model optimizacije slike za korisnike sa poremećajima viđenja boja." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=99904&source=NDLTD&language=en.

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Predmet disertacije jeste optimizacija digitalne slike kadaograničenje nije vezano za način reprodukcije već za samog posmatrača,odnosno optimizacija opaženog kvaliteta digitalne slike od straneosoba sa poremećajima viđenja boja. Predloženi model optimizacijeslike poboljšava distinkciju boja i opseg boja slike za korisnike sarazličitim težinama poremećaja viđenja boja uz očuvanje prirodnostislike. Metodološki okvir ispitivanja, koji uključuje kvantitativnuanalizu računarskih simulacija, analizu eye-tracking podataka isubjektivno ocenjivanje poboljšanja opaženog kvaliteta test slika,daje sistem

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20

Jiang, Bo. "Partition Models for Variable Selection and Interaction Detection." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10911.

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Variable selection methods play important roles in modeling high-dimensional data and are key to data-driven scientific discoveries. In this thesis, we consider the problem of variable selection with interaction detection. Instead of building a predictive model of the response given combinations of predictors, we start by modeling the conditional distribution of predictors given partitions based on responses. We use this inverse modeling perspective as motivation to propose a stepwise procedure for effectively detecting interaction with few assumptions on parametric form. The proposed procedur

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21

Van, Zyl Cecile. "A script development model for the creation of computer games / Cecile van Zyl." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4196.

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The concept of game development has traditionally not implemented the skills of professional writers to develop the scripts for a computer game. However, due to the growth in complexity and size of the computer game development process, as well as the growing teams of people involved in the development of computer games, the need to employ skilled writers has emerged in modern computer game development. It has, however, become clear that the role of the writer within the collaborative game development process is still ill-defined. And therefore, the writer who wishes to start writing for the g

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22

Stevens, Roger P., and n/a. "A Computer Model of the Cellular Slime Mould Dictyostelium Discoideum." Griffith University. School of Computing and Information Technology, 2002. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050906.112225.

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Excitable media are an important class of systems, examples of which include epidemics, predator-prey interactions, nervous systems, and heart muscle. Aggregating cellular slime moulds are an example of an excitable medium. The species of cellular slime mould Dictyostelium discoideum is an important model organism that many science laboratories use. Studying the aggregation of slime moulds increases knowledge about excitable media generally. One method of studying the aggregation of slime mould is to simulate theft behaviour on a computer model. This thesis presents the author's computer model

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Stevens, Roger P. "A Computer Model of the Cellular Slime Mould Dictyostelium Discoideum." Thesis, Griffith University, 2002. http://hdl.handle.net/10072/365409.

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Excitable media are an important class of systems, examples of which include epidemics, predator-prey interactions, nervous systems, and heart muscle. Aggregating cellular slime moulds are an example of an excitable medium. The species of cellular slime mould Dictyostelium discoideum is an important model organism that many science laboratories use. Studying the aggregation of slime moulds increases knowledge about excitable media generally. One method of studying the aggregation of slime mould is to simulate theft behaviour on a computer model. This thesis presents the author's computer model

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24

Olivieri, Dario. "New Spinal cord models: Characterization of Excitotoxicity and Neuroprotection." Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/3892.

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Group III metabotropic glutamate receptors (mGluR III) are known to decrease glutamate release and to play an important role in controlling pain as documented in neuropathic pain models. Much less is known about their potential neuroprotective effect against excitotoxicity that is considered important for damage onset of spinal cord injury. Using rat spinal cord organotypic slices model, we investigated if mGluR III receptor activation might contrast excitotoxic cell death evoked by kainic acid (0.1 mM) applied for 1h and followed by wash for further 24h. The specific agonist of mGluR III rece

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25

Coates, Nadya. "An evaluation of the Xenopus laevis liver slice model to study the toxic effects of microcystin." Thesis, University of Port Elizabeth, 2003. http://hdl.handle.net/10948/307.

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Blooms of cyanobacteria have increased in occurrence in the past three decades and have been reported to cause severe problems for animals and humans, leading to death in extreme instances. The majority of poisonings that have taken place have been attributed to a hepatotoxin produced by the species Microcystis aeruginosa, namely microcystin. The appearance of a cyanobacterial bloom does not give any indication as to its toxicity and therefore, it is imperative that simple, yet sensitive, bioassays are developed to overcome this problem. This study was undertaken to evaluate the effects of mic

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Uhl, Franziska [Verfasser], and Silke [Akademischer Betreuer] Meiners. "Determination of lung regeneration using an ex vivo tissue slice model / Franziska Uhl. Betreuer: Silke Meiners." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1077986955/34.

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27

Hamilton, Steven. "A Time-Dependent Slice Balance Method for High-Fidelity Radiation Transport Computations." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14608.

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A general finite difference discretization of the time-dependent radiation transport equation is developed around the framework of an existing steady-state three dimensional radiation transport solver based on the slice-balance approach. Three related algorithms are outlined within the general finite difference scheme: an explicit, an implicit, and a semi-implicit approach. The three algorithms are analyzed with respect to the discretizations of each element of the phase space in the transport solver. The explicit method, despite its small computational cost per time step, is found to be un

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28

Buzzelli, Daniela. "Tissue slice cultures of the lung : an in vitro model to study inflammation and anti-inflammatory compounds." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579766.

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The aim of the whole project was to establish Precision-Cut Slices (PCS) from rat lung as an in vitro model to study lung inflammation and test the anti-inflammatory and properties of natural occurring Vitamin E and chromanol- derived compounds. Furthermore, the use of the Raman Microscopy will allow investigating the distribution of these compound oxidation products in rat lung tissue sections. In the current investigation, establishment of PCS from rat lung included 1) assessment of viability of rat lung PCS using the MTT and LDH assays and histopathology, and 2) evaluation of responsiveness

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Hamouda, Ahmed Mohamed Abdelaty Elmekkawi. "Resource allocation and management under priorities based on the squatting-kicking model for multi-slice 5G networks." Doctoral thesis, Universitat Politècnica de Catalunya, 2021. http://hdl.handle.net/10803/672663.

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The upcoming Beyond Fifth Generation networks aim to meet network services characterized by low latency and high reliability among others in different slices to provide a high-quality user experience. However, existing best-effort networking schemes that implement traditional methods of controlling and allocating network and computing resources do not meet such strict service requirements well. In International Telecommunication Union-Telecommunication sector, future services are defined as Network 2030 Services under a chartered Focus Group on Networks 2030 (FG-NET2030). The results from the

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Jagielo-Miller, Julia Elaine. "CHARACTERIZING AN IN VITRO MODEL OF SEVERE FOCAL TRAUMATIC BRAIN INJURY IN HIPPOCAMPAL SLICE CULTURES: THE EFFECTS OF ETHANOL AND CALPAIN INHIBITION BY MDL-28170." UKnowledge, 2019. https://uknowledge.uky.edu/psychology_etds/166.

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In the United States, 2.8 million people suffer a traumatic brain injury (TBI) annually. Between 25%-50% of TBI injuries happen under alcohol intoxication. It is not understood how alcohol impacts patient outcomes via secondary injury pathways. Secondary injury pathways offer a window for therapeutic interventions, but there has been little success finding effective medications. Slice cultures offer a way to study secondary injury mechanisms in a controlled manner. The transection injury can model excitotoxicy seen following TBI. The current studies examined the effect of alcohol intoxication

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31

Mario, Šokac. "Hibridni model za segmentaciju snimaka generisanih primenom kompjuterizovane tomografije." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110955&source=NDLTD&language=en.

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Kompjuterizovana tomografija (CT) je u poslednje vreme ušla na velika vrata sa razvojem industrijskih CT sistema, usled njene primene u različitim oblastima, a uveliko ulazi i u polje koodinatne metrologije. Zbog karakterizacije objekata sačinjenih od različitih materijala (najčešće metala i plastike), javljaju se određeni problem u vidu nastanka artefakata kod rezultata dimenzionalnih merenja. Istraživanja koja su sprovedena u ovoj doktorskoj disertaciji se bave problemom redukcije uticaja tih artefakata i segmentacije 2D snimaka. Razvijen je novi model koji je baziran na primeni hibridne met

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32

Talei, Franzesi Giovanni. "Toward optogenetic control of neural synchrony : experimental results from the hippocampal slice model of gamma oscillations and computational modeling." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/63030.

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Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 52-58).<br>Ever since Hans Berger recorded the first human EEGs in humans and observed large, rhythmic 8 Hz field oscillations, neuroscientists have been intrigued by the pervasive presence of synchronized, regular patterns of the activity in the brain. A number of frequency bands, spanning from 0.1 to several hundred hertz have been described, and associated with particular funct

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Freeborn, Ethan Ray. "The Murine Brain Slice as a Model for Investigation of Environmental Toxin Involvement in the Etiology of Parkinson's Disease." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/9769.

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Epidemiological and analytical studies have suggested that environmental exposure to neurotoxic insecticides may exist as a factor in the etiology of Parkinson's Disease (PD). This study has focused on two insecticides, dieldrin and heptachlor epoxide, members of the cyclodiene class of insecticides. The cyclodienes are environmentally persistent, and brain residues of these compounds are correlated with the occurrence of PD. Cyclodiene mode of action has been attributed to two mechanisms: 1) facilitation of neurotransmitter release (with specificity for release of dopamine) and 2) antagonism

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Göbel-Guéniot, Katharina [Verfasser], Jan G. [Akademischer Betreuer] Korvink, and Jürgen [Akademischer Betreuer] Hennig. "Magnetic resonance microscopy in neuroscience: examination of nervous tissue microstructure and neuronal activity in a rodent hippocampal slice model." Freiburg : Universität, 2019. http://d-nb.info/1221959549/34.

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Gerlach, Magdalena. "Schnittkulturen von humanen Plattenepithelkarzinomen der Kopf-Hals-Region: Ein neues Modell zur Chemosensibilitätstestung." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-160372.

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Background: Human head and neck squamous cell carcinoma (HNSCC) fundamentally vary in their susceptibility to different cytotoxic drugs and treatment modalities. There is at present no clinically accepted test system to predict the most effective therapy for an individual patient. Methods: Therefore, we established tumor-derived slice cultures which can be kept in vitro for at least six days. Upon treatment with cisplatin, docetaxel and cetuximab, slices were fixed and paraffin sections were cut for histopathological analysis. Results: Apoptotic fragmentation, activation of caspase 3, and cel

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Záškodný, Jiří. "Model víceotáčkového motoru a simulace v programu ANSYS Maxwell." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2018. http://www.nusl.cz/ntk/nusl-377332.

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This master thesis deals with calculations and simulations of multi-speed induction motors. In the first part, basic principle of these machines is described. Next, there are given three examples of pole-changing stator windings and their properties are analyzed (winding factors, magnetomotive force). Main part includes simulations and measuring of the specific motor, which is produced by company Siemens Mohelnice. This is the motor with 2/1 pole-changing in Y/YY connection. First, influence of skewed rotor slots on current and torque is analyzed. Next, parametres of motor from simulations are

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Olsson, Anton, and Johan Welltén. "Mognadsmodell - Möjligheter inom industri 4.0 En förstudie på Cementa AB Slite." Thesis, KTH, Hållbar produktionsutveckling (ML), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-276250.

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Detta kandidatexamensarbete är en förstudie utfört på Cementa AB:s fabrik i Slite, Gotland, och grundar sig i att Cementa AB, Sveriges enda tillverkare av cement, står inför en omställning till helhetskonceptet Industri 4.0 som bygger på tekniker och principer för automation och digitalisering. Fabriken står även inför en hållbarhetsomställning, då branschen bidrar med stora koldioxidutsläpp genom sin tillverkning. Målet med kandidatexamensarbetet är att analyseravar Cementa AB står inför en Industri 4.0 omställning och även undersöka om det har någon koppling till deras hållbarhetsarbete. För

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Liang, Dong. "Issues in Bayesian Gaussian Markov random field models with application to intersensor calibration." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/400.

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A long term record of the earth's vegetation is important in studies of global climate change. Over the last three decades, multiple data sets on vegetation have been collected using different satellite-based sensors. There is a need for methods that combine these data into a long term earth system data record. The Advanced Very High Resolution Radiometer (AVHRR) has provided reflectance measures of the entire earth since 1978. Physical and statistical models have been used to improve the consistency and reliability of this record. The Moderated Resolution Imaging Spectroradiometer (MODIS) has

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Wang-Lauenstein, Lan [Verfasser]. "Assessment of chemical-induced local irritation and inflammation in organotypic lung tissue model : precision-cut lung slices (PCLS) / Lan Wang-Lauenstein." Hannover : Technische Informationsbibliothek (TIB), 2017. http://d-nb.info/1128673576/34.

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Ekins, Sean. "Maintenance and cryopreservation of xenobiotic metabolism in precision-cut liver slices : evaluation of an alternative in vitro model to isolated hepatocytes." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU543199.

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Enzyme-specific substrate activities were higher in Sprague Dawley rat hepatocytes than slices; testosterone (250M) hydroxylations (1.9-16.9 fold), 7-ethoxycoumarin (25M) (O-deethylation, 14.8 fold, glucuronidation, 3.1 fold), carbamazepine (50M) epoxidation (2.4 fold), styrene (2mM) diol formation (9.7 fold) and CDNB (50M)-glutathione conjugate formation (8.7 fold). Most importantly, the ratio of 7-hydroxycoumarin sulphate to glucuronide conjugation was higher in slices, in agreement with the lower rate of 7-hydroxycoumarin formation and indicative of slower diffusion of 7-ethoxycoumarin into

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Sygnecka, Katja. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-188897.

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The development of new therapeutical approaches, devised to foster the regeneration of neuronal circuits after injury and/or in neurodegenerative diseases, is of great importance. The impairment of dopaminergic projections is especially severe, because these projections are involved in crucial brain functions such as motor control, reward and cognition. In the work presented here, organotypic brain slice co-cultures of (a) the mesostriatal and (b) the mesocortical dopaminergic projection systems consisting of tissue sections of the ventral tegmental area/substantia nigra (VTA/SN), in combinati

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Colombo, L. "RODENT ORGANOTYPIC BRAIN SLICES AS AN INTEGRATED MODEL TO STUDY THE EFFECTS OF HYPOXIC ISCHEMIA AND REPERFUSION AND TO DISSECT THE SPECIFIC ROLE OF MICROGLIAL CELLS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/170270.

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Stroke is the second leading cause disability in high-income countries and of death worldwide: several pharmacological therapies for acute stroke are currently available, but their efficacy is limited. New potential therapeutical targets have been identified in the neuroinflammatory response after ischemia, where a fundamental role is played by microglial cells, especially during the acute post-traumatic phase. Among other players, ATP and other nucleotides play a pivotal role, being released in high amount in the extracellular spaces, with both beneficial and detrimental effects: their actio

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Milana, Ilić Mićunović. "Model za evaluaciju rezultata merenja karakteristika praškastih materija zasnovan na elektronskoj mikroskopiji." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107506&source=NDLTD&language=en.

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Istraživanje u okviru doktorske disertacije obuhvata uzorkovanja inhalativne frakcije praškastih materija generisane u zubotehničkoj laboratoriji i procesom brušenja čelika EN 90MnCrV8, primenu savremenih metodologija uzorkovanja, analizu uzorka laserskom difrakcijom i analizom slike, zasnovanom na mikrografijama skenirajućeg elektronskog mikroskopa i statističku obradu podataka. Osnovni cilj istraživanja je razvoj funkcionalnog modela za evaluaciju rezultata merenja karakteristika praškastih materija, koji je obuhvatio identifikaciju, procenu i vrednovanje karakteristika prahova, u cilju unap

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Tomobe, Haruka. "Constitutive Models for Root-Soil Contact Interface Considering Hydro-Mechanical Effects." Kyoto University, 2020. http://hdl.handle.net/2433/253327.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第22491号<br>農博第2395号<br>新制||農||1076(附属図書館)<br>学位論文||R2||N5271(農学部図書室)<br>京都大学大学院農学研究科地域環境科学専攻<br>(主査)教授村上章, 教授藤原正幸, 教授白岩立彦<br>学位規則第4条第1項該当

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Langer, Zdeněk. "Hnací ústrojí řadového tříválcového vznětového motoru." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-227888.

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Increasing requirements on products quality e.g. internal combustion engines, and growing demand on producing major parts lead to the giant development of the engines. With the engine development also great progress in the software tools has come. By decreasing costs on production of the prototypes and by support of the measured data the verification of the computational models is possible. This development has connection with using CAE tools like CAD systems, FEM programs and multi-body systems. The subject of this thesis is about using these systems to solve cranktrain dynamic. Also cranktra

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Rohozhyna, N., Ivan Samoilenko, and Ksenia Meleshko. "Procedure of editing existing polygonal models by SolidWorks system." Thesis, National aviation university, 2021. https://er.nau.edu.ua/handle/NAU/52829.

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1. 2021 Best 3D Printer Slicer Software [Electronic resource]. - Access mode: https://all3dp.com/1/best-3d-slicer-software-3d-printer/<br>The ability to use 3D printing technology directly depends on the quality of the input geometric model. It is usually difficult to see small defects, missing triangles, convex and other deformations of the grid in slicers. There are online services stlfixers that fix network models. They quickly fill in defects, but are limited by the size and number of triangles of the model. In this case, slicers "do not see" the smallest holes in the grid or one / two tri

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Barth, Melanie [Verfasser]. "Organotypic slice culture models for induced alpha-synucleinopathy and exploration of the potential role of microglia in pathogenesis / Melanie Barth." Tübingen : Universitätsbibliothek Tübingen, 2023. http://d-nb.info/1238595006/34.

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Hénot, Marceau. "Glissement de polymères liquides." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS194/document.

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L’objectif général de cette thèse était d’identifier les mécanismes moléculaires du frottement d’un fluide de polymère sur une surface solide à partir de l’écart à la condition de vitesse nulle à la paroi.La première partie de cette thèse a consisté à développer une nouvelle méthode de mesure du glissement des liquides de polymère par suivi d’un motif photolysé dans un fluide fluorescent. Cette méthode, qui est une évolution de celle utilisée précédemment dans le groupe, donne directement accès au champ de déplacement du fluide lors de l’écoulement. À l’aide de ce nouveau dispositif, nous avon

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TELESCA, ALESSIO. "ADVANCED MODELLING OF OVER-STROKE DISPLACEMENT CAPACITY FOR CURVED SURFACE SLIDER DEVICES." Doctoral thesis, Università degli studi della Basilicata, 2022. http://hdl.handle.net/11563/153765.

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This doctoral dissertation aims to report on the research work carried out and to provide a contribution to the field of seismic base isolation. Since its introduction, the base isolation strategy proved to be an effective solution for the protection of structures and their components from the earthquake-induced damage, enhancing their resilience and implying a significative decrease in time and cost of repair compared to a conventional fixed-base structure. Sliding isolation devices feature some important characteristics, over other devices, that make them particularly suitable for the appli

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Wang, Shu. "Identification of dynamical models of spatio-temporal pattern formation with applications to slime mould." Thesis, University of Sheffield, 2011. http://etheses.whiterose.ac.uk/1997/.

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Spatio-temporal systems are non-linear dynamical systems which include both time and space information. Many natural phenomena and processes can be described by spatio-temporal models, such as pattern formation, chemical reactions and physical dynamics. The main focus of this thesis is on the investigation of analysis and identification methods for spatio-temporal systems and the application of these methods to the dynamics of slime mould. This thesis starts with a review of recent developments of spatio-temporal systems. Three general classes of spatio-temporal systems, Cellular Automata (CA)

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