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Journal articles on the topic 'Sodium Citrate HPLC Determination'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Abdrhman, Mahmoud Gamil, and Awad al-lkareem Hamad Mohamed. "Development and validation of stability indicating method for determination of sodium citrate in pediatric cough syrup." World Journal of Advanced Research and Reviews 8, no. 2 (2020): 213–23. https://doi.org/10.5281/zenodo.4318624.

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Sodium Citrate is widely used in analytical and food processes. It is used in various medical applications as anticoagulant in blood transfusion process and bladder washout. It is used in cough preparation as mucolytic. There are many methods for determination of Sodium Citrate in different preparations. Some of which use spectrophotometric methods, others used HPLC methods. The USP method uses titration and determining the end point potentionometrically. Many arguments take place between the Drug Regulatory Affairs and manufacturers regarding the appearance of the colour at the end point. The

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2

Williams, Robert H., Jack A. Maggiore, Robert D. Reynolds, and Cathy M. Helgason. "Novel Approach for the Determination of the Redox Status of Homocysteine and Other Aminothiols in Plasma from Healthy Subjects and Patients with Ischemic Stroke." Clinical Chemistry 47, no. 6 (2001): 1031–39. http://dx.doi.org/10.1093/clinchem/47.6.1031.

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Abstract Background: Plasma “redox” status can be assessed by measurements of reduced (r)-, free (f)-, oxidized (ox)-, and protein-bound (b)-homocysteine (Hcy) plus the related aminothiols cysteine, cysteinylglycine (CysGly), and glutathione (GSH), but sample collection has been complex. The redox status has not been determined in ischemic stroke patients and may provide increased understanding of its role in pathogenesis. We wished to examine the feasibility of this measurement in samples collected in readily available acidic sodium citrate. Methods: We measured aminothiols and their stabilit

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Abdrhman Mahmoud Gamil and Mohamed Awad al-lkareem Hamad. "Development and validation of stability indicating method for determination of sodium citrate in pediatric cough syrup." World Journal of Advanced Research and Reviews 8, no. 2 (2020): 213–23. http://dx.doi.org/10.30574/wjarr.2020.5.2.0427.

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Sodium Citrate is widely used in analytical and food processes. It is used in various medical applications as anticoagulant in blood transfusion process and bladder washout. It is used in cough preparation as mucolytic. There are many methods for determination of Sodium Citrate in different preparations. Some of which use spectrophotometric methods, others used HPLC methods. The USP method uses titration and determining the end point potentionometrically. Many arguments take place between the Drug Regulatory Affairs and manufacturers regarding the appearance of the colour at the end point. The

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4

Abdrhman Mahmoud Gamil and Mohamed Awad al-lkareem Hamad. "Development and validation of stability indicating method for determination of sodium citrate in pediatric cough syrup." World Journal of Advanced Research and Reviews 8, no. 2 (2020): 213–23. http://dx.doi.org/10.30574/wjarr.2020.8.2.0427.

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Sodium Citrate is widely used in analytical and food processes. It is used in various medical applications as anticoagulant in blood transfusion process and bladder washout. It is used in cough preparation as mucolytic. There are many methods for determination of Sodium Citrate in different preparations. Some of which use spectrophotometric methods, others used HPLC methods. The USP method uses titration and determining the end point potentionometrically. Many arguments take place between the Drug Regulatory Affairs and manufacturers regarding the appearance of the colour at the end point. The

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5

El-Fatatry, Hamed M., Mokhtar M. Mabrouk, Ismail I. Hewala, and Ehab H. Emam. "Stability-indicating HPLC–DAD methods for determination of two binary mixtures: Rabeprazole sodium–mosapride citrate and rabeprazole sodium–itopride hydrochloride." Journal of Pharmaceutical Analysis 4, no. 4 (2014): 258–69. http://dx.doi.org/10.1016/j.jpha.2013.09.009.

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6

Khedr, Alaa, Mohamed Moustafa, Ashraf B. Abdel-Naim, Abdulrahman Alahdal, and Hisham Mosli. "High-Performance Liquid Chromatographic Method for Determination of Phenytoin in Rabbits Receiving Sildenafil." Analytical Chemistry Insights 3 (January 2008): ACI.S658. http://dx.doi.org/10.4137/aci.s658.

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A validated high-performance liquid chromatographic (HPLC) method for determination of phenytoin (PHN), para-hydroxy metabolite of phenytoin (POH) and sildenafil (SIL) in rabbit plasma is described. The method is based on extraction on Sep-Pak C18 solid support using ethyl acetate and ether as eluents and monitoring at 220 nm. The extracted samples were analyzed by HPLC using Agilent Zorbax Extended C18 column (150 mm x 4.6 mm internal diameter) and isocratic elution with a mobile phase consist of 29% acetonitrile and 71% sodium acetate solution (0.02 M, pH 4.6). The method was fully validated

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7

Xu, Quanyun A., Lawrence A. Trissel, and Juan F. Martinez. "Drug Stability: Rapid Loss of Fentanyl Citrate Admixed with Fluorouracil in Polyvinyl Chloride Containers." Annals of Pharmacotherapy 31, no. 3 (1997): 297–302. http://dx.doi.org/10.1177/106002809703100305.

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Objective To study the physical compatibility and chemical stability of fluorouracil 1 and 16 mg/mL with fentanyl citrate 12.5 μg/mL in dextrose 5% and in sodium chloride 0.9% injection. Design Test solutions of the drugs in dextrose 5% injection and in sodium chloride 0.9% injection were prepared in triplicate and stored at −20, 4, 23, and 32 °C. Samples were removed immediately and at various times over 7 days and stored at −70 °C until analyzed. Physical compatibility was assessed visually and by measuring turbidity with a color-correcting turbidimeter; particle content was measured with a

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8

Wongchang, Thamrong, Markus Winterberg, Joel Tarning, Natthida Sriboonvorakul, Sant Muangnoicharoen, and Daniel Blessborn. "Determination of ceftriaxone in human plasma using liquid chromatography–tandem mass spectrometry." Wellcome Open Research 4 (May 31, 2022): 47. http://dx.doi.org/10.12688/wellcomeopenres.15141.3.

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Ceftriaxone is a cephalosporin antibiotic drug used as first-line treatment for a number of bacterial diseases. Ceftriaxone belongs to the third generation of cephalosporin and is available as an intramuscular or intravenous injection. Previously published pharmacokinetic studies have used high-performance liquid chromatography coupled with ultraviolet detection (HPLC-UV) for the quantification of ceftriaxone. This study aimed to develop and validate a bioanalytical method for the quantification of ceftriaxone in human plasma using liquid chromatography followed by tandem mass spectrometry (LC

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9

Wongchang, Thamrong, Markus Winterberg, Joel Tarning, Natthida Sriboonvorakul, Sant Muangnoicharoen, and Daniel Blessborn. "Determination of ceftriaxone in human plasma using liquid chromatography–tandem mass spectrometry." Wellcome Open Research 4 (September 3, 2021): 47. http://dx.doi.org/10.12688/wellcomeopenres.15141.2.

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Ceftriaxone is a cephalosporin antibiotic drug used as first-line treatment for a number of bacterial diseases. Ceftriaxone belongs to the third generation of antibiotics and is available as an intramuscular or intravenous injection. Previously published pharmacokinetic studies have used high-performance liquid chromatography coupled with ultraviolet detection (HPLC-UV) for the quantification of ceftriaxone. This study aimed to develop and validate a bioanalytical method for the quantification of ceftriaxone in human plasma using liquid chromatography followed by tandem mass spectrometry (LC-M

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10

Grechina, Marina S., Alena V. Suslova, and Viktoriya V. Belitskaya. "On the issue of analytical control of quinone derivatives in habitats." Toxicological Review 29, no. 4 (2021): 45–50. http://dx.doi.org/10.36946/0869-7922-2021-29-4-45-50.

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Introduction. In the direction of normative and methodological assurance of the safety of environmental objects and imported food products, analytical approaches to the determination of a fungicide of the quinone class - dithianone in the air and citrus fruits were optimized. Materials and methods. Measurements were performed by tandem liquid mass spectrometry with a triple quadrupole mass detector (HPLC-MS/MS) in multiple reaction monitoring (MRM) mode using electrostatic spray as the ionization source. The substance from the air was concentrated on Tenax TA sorption tubes based on a porous p

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11

Khlebus, N. K. "Quality indicators of a complex veterinary drug with hepatoprotective effect and their control." International Journal of Veterinary Medicine, no. 2 (June 29, 2023): 127–33. http://dx.doi.org/10.52419/issn2072-2419.2023.2.127.

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Hepatopathy (toxic hepatitis and hepatosis) are widespread among sows kept in industrial complexes. To carry out therapeutic and preventive measures for these diseases, a complex drug with a hepatoprotective effect is in demand. In its industrial production, quality control is necessary with an assessment of the presence and quantity of active components. To control of the quality of the Karnivit drug, organoleptic (appearance and color), chromatographic (high performance liquid chromatography - HPLC) (authenticity and mass concentration of vitamin E and carnitine), qualitative chemical (authe

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12

Munib-ur-Rehman, Rabia Ismail Yousuf, and Muhammad Harris Shoaib. "A Stability-Indicating High Performance Liquid Chromatographic Assay for the Simultaneous Determination of Pyridoxine, Ethionamide, and Moxifloxacin in Fixed Dose Combination Tablets." Chromatography Research International 2014 (April 23, 2014): 1–8. http://dx.doi.org/10.1155/2014/258125.

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Stability indicating reversed phase HPLC method was developed and validated for the simultaneous quantitation of antitubercular drugs, ethionamide (ETH), and moxifloxacin (MOX) with commonly coprescribed vitamin, pyridoxine (PYR) in tablet dosage form. The method was found rapid, precise and accurate. The separation was performed in Hibar 150-4.6, Purospher STAR, RP-18e (5 μm) column, using mobile phase A (0.03 M sodium citrate adjusted to pH 5 with glacial acetic acid) and mobile phase B (100% methanol), ran at variable proportions at flow rate of 1.0 mL/min. The detection was carried out at

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13

Wentao, Gong, and Chen Chen. "Determination of diclofenac sodium by HPLC method." Modern Analytical Chemistry Research 1, no. 1 (2019): 13–17. http://dx.doi.org/10.35534/macr.0101003c.

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14

Wang, Xue, Bo Jin, Zhijun Wang, Kaijing Guo, Tingting Zhang, and Chen Ma. "Determination of Enantiomer in Tofacitinib Citrate Using Reversed-Phase Chiral High-Performance Liquid Chromatography." Separations 11, no. 3 (2024): 89. http://dx.doi.org/10.3390/separations11030089.

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Tofacitinib citrate (RR-isomer) is a janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis (RA) in adults who have had an inadequate response or intolerance to methotrexate. The presence of the enantiomer of tofacitinib citrate (SS-isomer) is monitored for quality control as a possible impurity in the final product. In this study, a reversed-phase high-performance liquid chromatography (RP-HPLC) method based on a chiral recognition mechanism for the separation of tofacitinib citrate and its enantiomer was established based on the principles of green analytical chemist

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15

Beloti, Vanerli, Edson Antonio Rios, Márcia Rocha Silva, Ronaldo Tamanini, Alberto Koji Yamada, and Livia Cavaletti Correa da Silva. "Determination of freezing point standard for UHT milk." Semina: Ciências Agrárias 36, no. 5 (2015): 3181. http://dx.doi.org/10.5433/1679-0359.2015v36n5p3181.

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<p>The extended shelf life and undemanding storage requirements of UHT (ultra high temperature) milk make it the most consumed fluid milk in Brazil. The thermal treatment to which UHT milk is subjected alters casein micellar structure, leading to protein sedimentation and age gelation. Therefore, the current legislation allows the addition of up to 0.1% stabilizing salts (sodium citrate and/or sodium phosphates) in milk. The adding of stabilizing salts hinders the possibility of inclusion of freezing point and density as quality parameters of UHT milk. Evaluation of freezing point is the

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16

Yoewono, Jessica Renata, Oki Krisbianto, Yurika Sugiharto, and Lorent Permata Ridfan. "Acceptance Test of Jokowi's Herbal Beverage with Antioxidant Properties in Isotonic Beverage Formulation." Jurnal Ilmu Pangan dan Hasil Pertanian 7, no. 2 (2024): 166–80. http://dx.doi.org/10.26877/jiphp.v7i2.17288.

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A herbal beverage mixture based on extracts of turmeric (Curcuma longa), Javanese turmeric (Curcuma xanthorrhiza), and red ginger (Zingiber officinale) with a ratio of 8:6:3 was developed as an isotonic beverage after describing its sensory characteristics and antioxidant properties. Three different dilutions (1:10, 1:15, and 1:20) were used for sensory acceptance testing by consumers. Antioxidant activity tests using DPPH followed by HPLC were conducted on each extract as well as the most concentrated dilution and the best treatment. The sensory testing results indicated that the 1:20 dilutio

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17

Pujol, M., V. Girona, J. Prat, and J. Cots. "HPLC determination of azlocillin sodium for stability studies." International Journal of Pharmaceutics 58, no. 2 (1990): 103–6. http://dx.doi.org/10.1016/0378-5173(90)90246-z.

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18

Chantarangkul, V., A. Tripodi, and A. M. H. P. van den Besselaar. "A Comparison of Two Sodium Citrate Concentrations in Two Evacuated Blood Collection Systems for Prothrombin Time and ISI Determination." Thrombosis and Haemostasis 84, no. 10 (2000): 664–67. http://dx.doi.org/10.1055/s-0037-1614084.

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SummaryThe prothrombin time is usually measured in citrated plasma. The W.H.O. recommended concentration of sodium citrate for blood collection for laboratory control of oral anticoagulant therapy is 0.109 M. Some evacuated blood collection systems include 0.105 M sodium citrate. The purpose of the present study was to establish the difference in ISI calibration between 0.109 and 0.105 M citrate, using 7 types of thromboplastin and various types of instrumentation. The two citrate concentrations were provided in both evacuated siliconised glass tubes and in evacuated polyethylene terephtalate

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19

Tihonova, V. V., O. A. Terenteva, K. A. Gusev, E. V. Flisyuk, and D. N. Maimistov. "Development and Validation of HPLC Method for Identification of Ramipril in Printed Tablets and Filaments." Drug development & registration 11, no. 4 (2022): 209–15. http://dx.doi.org/10.33380/2305-2066-2022-11-4-209-215.

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Introduction. 3D printing has shown its usefulness as a drug manufacturing technology over the past decade. However, the lack of regulated methods for quality control of finished printed drugs imposes a limitation on the widespread use of 3D printing methods in pharmaceutical practice. Thus, the development of methods for the analysis of printed dosage forms is of interest in pharmaceutical development.Aim. To develop a specific method for the determination of ramipril in filaments and printlets by HPLC.Materials and methods. Substance: ramipril. Excipients: Kollidon® VA 64, Kollidon® CL-F, PE

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20

Hafsa, Deshmukh, S. Chanda, and Pradnya J. Prabhu. "Simultaneous HPLC Determination of Methocarbamol, Paracetamol and Diclofenac Sodium." E-Journal of Chemistry 8, no. 4 (2011): 1620–25. http://dx.doi.org/10.1155/2011/614748.

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A rapid and simple high performance liquid chromatography method was developed and validated at λ=275 nm for simultaneous determination of methocarbamol, paracetamol and diclofenac sodium (lamotrigine as an internal standard) from pharmaceutical preparation. The separation was performed using methanol: water: GAA, in the ratio of 400:600:05 (v/v) as the mobile phase. The detector response was linear in the range of 5 to 45 μg, 3.25 to 29.25 μg, 0.5 to 4.5 μg for methocarbamol, paracetamol and diclofenac sodium respectively. The percentage assay of methocarbamol, paracetamol and diclofenac sodi

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Habimana, V., A. S. Nguluma, Z. C. Nziku, et al. "An HPLC-MS/MS method for the quantification of heat stress-related milk metabolites in milk from Holstein-Friesian cross-bred cows in Tanzania." South African Journal of Animal Science 55, no. 3 (2025): 154–72. https://doi.org/10.4314/sajas.v55i3.07.

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The main objective of this study was to develop and validate a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the determination and quantification of three metabolites in raw milk samples: creatinine, citrate, and β-hydroxybutyrate (3-BHB). The effect of the temperature-humidity index (THI) on the concentrations of these metabolites was also investigated. The study used 29 Holstein-Friesian × Tanzanian Shorthorn Zebu cross-bred cows of two genotypes from the Tanzania Livestock Research Institute in Tanga, Tanzania. The cows were in their second or third

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22

Lanças, F. M., O. R. de Sá, S. R. Rissato, and M. S. Galhiane. "HPLC/UV Determination of Sodium Acifluorfen in Tropical Fish." Journal of Liquid Chromatography & Related Technologies 20, no. 12 (1997): 1945–57. http://dx.doi.org/10.1080/10826079708005554.

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23

Ahmed Atto, Riyadh. "New method for determination of diclofenac sodium by High Performance Liquid Chromatography." Tikrit Journal of Pharmaceutical Sciences 8, no. 1 (2023): 60–67. http://dx.doi.org/10.25130/tjphs.2012.8.1.8.60.67.

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In this study a simple, coast effective and direct simple High Performance Liquid Chromatography (HPLC) method has been developed for the determination of diclofenac sodium in it's pure form and different pharmaceutical preparations. Standard diclofenac sodium and its dosage forms were supplied from Ninava State Company For Drug Industries and Medical Appliances (NDI). HPLC method was developed by using mobile phase which was composed of a mixture of HPLC grade (methanol, acetonitrile and deionized water)in the ratio of (60:20:20) respectively. Separation has been completed within 2 min. Calib

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24

Pirol, Ozan, Murat Sukuroglu, and Tuncel Ozden. "Simultaneous Determination of Paracetamol, Phenylephrine Hydrochloride, Oxolamine Citrate and Chlorpheniramine Maleate by HPLC in Pharmaceutical Dosage Forms." E-Journal of Chemistry 8, no. 3 (2011): 1275–79. http://dx.doi.org/10.1155/2011/454325.

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A new high performance liquid chromatographic (HPLC) method was developed for the determination of paracetamol, phenylephrine hydrochloride, oxolamine citrate and chlorpheniramine maleate in combined pharmaceutical formulations and dosage forms. The separation was performed on an Agilent Zorbax SB-CN column with the mobile phase consisting of 0.02 M phosphate buffer (pH:4) and acetonitrile (85:15,v/v) in flow rate 1.5 mL at 22 °C. The overall retention time of the analytes was 3.5 min. The method was validated with respect to linearity, precision, accuracy and recovery. The relative standard d

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25

Tarabas, O. V., S. O. Hnatush, O. B. Tashyrev, et al. "Production of Hydrogen by Purple Non-Sulfur Bacteria Rhodopseudomonas yavorovii IMV B-7620." Mikrobiolohichnyi Zhurnal 83, no. 5 (2021): 19–29. http://dx.doi.org/10.15407/microbiolj83.05.019.

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Hydrogen production by microorganisms is studied by using different sources of carbon for their cultivation. Purple non-sulfur bacteria are capable of producing molecular hydrogen phototrophically with the simultaneous accumulation of biomass on organic substrates that may be waste from various industries. That fact makes the study of this group of microorganisms very much promising. The aim. The determination of the ability of purple non-sulfur bacteria Rhodopseudomonas yavorovii IMV B-7620 to produce hydrogen consuming different organic substrates and their effects on the main metabolic indi

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26

Patel, Aasha, Sandip D. Firke, Ravindra R. Patil, Mohan G. Kalaskar, Sanjay B. Bari, and Sanjay J. Surana. "SIMULTANEOUS DETERMINATION OF DOMPERIDONE AND SOME PRESERVATIVES IN ORAL FORMULATION: RP-HPLC METHOD." INDIAN DRUGS 57, no. 05 (2020): 71–73. http://dx.doi.org/10.53879/id.57.05.11282.

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A novel RP-HPLC method was developed and validated for the determination of compounds in an oral solution. The method describes the determination of domperidone along with sodium methylparaben, sodium propylparaben and sodium benzoate in liquid oral formulation. Chromatographic separations were performed using BDS Hypersil 5 μm C18 column and gradient elution (solvent A: phosphate buffer, pH 3.5 and solvent B: methanol), keeping a flow rate of 1.5 mL/min. Detection was done at dual wavelength (232 nm for domperidone and sodium benzoate, and 257 nm for sodium methylparaben and sodium propylpara

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27

Aboul‐Enein, Hassan Y., and Mohamed M. Hefnawy. "Rapid Determination of Sildenafil Citrate in Pharmaceutical Preparations Using Monolithic Silica HPLC Column." Journal of Liquid Chromatography & Related Technologies 26, no. 17 (2003): 2897–908. http://dx.doi.org/10.1081/jlc-120025052.

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Palfrey, S. M. "Determination of 4-Hydroxy-3-Methoxymandelic Acid in Urine using HPLC with Electrochemical Detection." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 24, no. 2 (1987): 172–76. http://dx.doi.org/10.1177/000456328702400208.

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A method is described for the assay of 4-hydroxy-3-mcthoxymandelic acid (HMMA) in urine using IIPLC coupled with electrochemical detection. In this method acidified urine is extracted with ethyl acetate which is then washed with the chromatography solvent to back extract HMMA. The solvent is a pH 50 citrate buffer. At this pH, HMMA separates clearly from all other electroactive compounds present in urine.

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29

Derouicha, Matmour, Zohra Hadjadj Aoul Fatima, and Houari Toumi. "Comparative Utilization of Potentiometric Titration and HPLC Methods for Content Determination of Propranolol Raw Material." Pharmaceutical and Chemical Journal 6, no. 1 (2019): 49–52. https://doi.org/10.5281/zenodo.13931555.

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This study describes an application and comparative evaluation of a HPLC and potentiometric titration methods to quantify the content of Propranolol in raw material. HPLC analysis were carried out using a C18 column and mobile phase composed of 1.6 g sodium lauryl sulfate, 0.31 g tetrabutylammonium dihydrogen phosphate, 1 ml sulfuric acid, 450 ml of water and 550 ml acetonitrile, with a flow rate of 1.8 ml/min and UV detection at 292 nm. The titration method of Propranolol was carried out using sodium hydroxide 0.1M as titrant and ethanol as solvent. The end point was potentiometrically determ

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Lian, Xiaofang, Yiran Li, Limin Zuo, et al. "Comparison and Determination of the Content of Mosapride Citrate by Different qNMR Methods." International Journal of Molecular Sciences 25, no. 19 (2024): 10442. http://dx.doi.org/10.3390/ijms251910442.

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As a salt-type compound, mosapride citrate’s metabolism and side effects are correlated with its salt-forming ratio. Several techniques were developed in this work to compare various quantitative nuclear magnetic resonance (qNMR) methodologies and to quantitatively examine the content of raw materials. Among the qNMR techniques, methods for 1H NMR and 19F NMR were developed. Appropriate solvents were chosen, and temperature, number of scans, acquisition time, and relaxation delay parameter settings were optimized. Maleic acid was chosen as the internal standard in 1H NMR, and the respective ch

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31

Petrarulo, Michele, Marta Leporati, Federica Pullara, et al. "Sensitive Ion-Chromatographic Determination of Citric Acid in Urine." Separations 9, no. 6 (2022): 143. http://dx.doi.org/10.3390/separations9060143.

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Urine citrate analysis is relevant in the screening and monitoring of patients with calcium nephrolithiasis. A sensitive, fast, easy, and low-maintenance ion chromatographic (IC) method with conductivity detection for the analysis of urine citrate is developed and validated. Its application on true samples is also reported. Sample urine is diluted with a water solution containing internal standard (IS) before the chromatographic assay. The isocratic chromatographic run time is twenty-five minutes, using sodium hydroxide aqueous solution as the mobile phase. The method is fully validated as a q

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32

Reddy, B. Prasanna Kumar, and Y. Ramanjaneya Reddy. "Validation and Stability Indicating RP-HPLC Method for the Determination of Sildenafil Citrate in Pharmaceutical Formulations and Human Plasma." E-Journal of Chemistry 5, s2 (2008): 1117–22. http://dx.doi.org/10.1155/2008/682924.

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A simple, selective, accurate reverse phase-high performance liquid chromatographic (RP-HPLC) method was developed and validated for the analysis of sildenafil citrate in pharmaceutical formulations. Chromatographic separation achieved isocratically on a C18column (Use Inertsil C18, 5μ , 150 mm x 4.6 mm) utilizing a mobile phase of acetonitrile/phosphate buffer (70:30, v/v, pH 7.0) at a flow rate of 0.8 mL/m with UV detection at 228 nm. The retention time was 4.087. The method is accurate (99.15-101.85%), precise (intra-day variation 0.13-1.56% and inter-day variation 0.30-1.60%) and linear wi

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33

Gros, Nataša. "Virtual Instruments for Peak-Overlapping Studies to Determine Low- and High-Concentration Components with Ion Chromatography: Potassium and Sodium." Molecules 29, no. 20 (2024): 4882. http://dx.doi.org/10.3390/molecules29204882.

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We developed the LabVIEW-based virtual instruments (VIs) to bridge a gap in commercial software and to enable systematic peak-overlapping studies to recognise the concentration levels enabling reliable simultaneous determination of major and minor constituents in samples with wide concentration proportions. The VIs were applied to a case study of the ion chromatographic determination of potassium as minor and sodium as a major ion with an IonPac CS12A column and 50 μL injection loop. Two successive studies based on multilevel two-factorial response surface experimental designs, (1) a model pea

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34

Ruckmani, K., Saleem Z. Shaikh, Pavne Khalil, M. S. Muneera, and O. A. Thusleem. "Determination of sodium hyaluronate in pharmaceutical formulations by HPLC–UV." Journal of Pharmaceutical Analysis 3, no. 5 (2013): 324–29. http://dx.doi.org/10.1016/j.jpha.2013.02.001.

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35

King, D. T., J. T. Stewart, and T. G. Venkateshwaran. "HPLC Determination of Propofol-Thiopental Sodium and Propofol-Ondansetron Mixtures." Journal of Liquid Chromatography & Related Technologies 19, no. 14 (1996): 2285–94. http://dx.doi.org/10.1080/10826079608017157.

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36

Ali, Muthana S., Ali E. Karim, Maiser Z. Mohye, Azza M. Al-metwali, and Salah N. Ibrahim. "Simultaneous determination of Guaifenesin, codeine phosphate, phenylephrine hydrochloride, and sodium benzoate in syrup pharmaceutical form by RP-HPLC." Al-Kitab Journal for Pure Sciences 7, no. 2 (2023): 173–83. http://dx.doi.org/10.32441/kjps.07.02.p13.

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This work describes the development of the RP-HPLC method for the simultaneous estimation of Guaifenesin, codeine phosphate, phenylephrine, and sodium benzoate. This method separates Guaifenesin, codeine phosphate, phenylephrine, and sodium benzoate nicely. This RP-HPLC method uses the Shimadzu HPLC instrument with Chromegabond WR C18 column 5 μm 120 A 30 cm * 3.9 mm. The mobile phase is a mixture of 1% o-phosphoric acid, methanol: acetonitrile (80 : 10: 10), and the pH was adjusted to 3.1. Isocratic elution mode was used with 1 ml/min as the flow rate. The detection for all compounds is carri

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Chase, G. William, William O. Landen, Leslie T. Gelbaum, and Abdel-Gawad M. Soliman. "Ion-Exchange Chromatographic Determination of Hypoglycin A in Canned Ackee Fruit." Journal of AOAC INTERNATIONAL 72, no. 2 (1989): 374–77. http://dx.doi.org/10.1093/jaoac/72.2.374.

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Abstract An ion-exchange chromatographic method was developed to determine hypoglycin A (HG-A) levels in canned ackee fruit by using an amino acid analyzer. HG-A was extracted by homogenizing the sample in 80% alcohol. An isocratic buffer system, consisting of 30% sodium citrate buffer (pH 3.15) and 70% sodium chloride-sodium acetate buffer (pH 7.40) was used to obtain baseline separation between HG-A and the other amino acids. The system can detect HGA levels as low as 4.8 μg/mh. HG-A levels in the edible portion of fruit in 6 cans ranged from 11.0 to 66.5 mg HG-A/can. Recoveries by standard

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Tanturovski, Zharko, Zorica Arsova-Sarafinovska, and Aneta Dimitrovska. "RP-HPLC method with indirect UV detection for determination of sodium ibandronate in pharmaceuticals." Macedonian Pharmaceutical Bulletin 64, no. 02 (2019): 43–49. http://dx.doi.org/10.33320/maced.pharm.bull.2018.64.02.005.

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Ibandronate sodium (IBN) [(1-hydroxy-3- (methyl pentyl amino) propylidene bisphosphonic acid monosodium monohydrate)] is the sodium salt of ibandronic acid, a synthetic nitrogen-containing bisphosphonate drug. The aim of this study was to develop a sensitive and accurate RP-HPLC method with indirect UV detection for determination of IBN in pharmaceutical formulations. Chromatographic separation was performed on a Waters Bridge C18 reversed-phase column (250 x 4.6 mm I.D.; particle size 5 µm), in an isocratic mode with a mobile phase constituted of 90% buffer: 10% acetonitrile (V/V). The buffer

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39

Gaucheron, Frédéric, Marie-Hélène Famelart, and Yvon Le Graët. "Iron-supplemented caseins: preparation, physicochemical characterization and stability." Journal of Dairy Research 63, no. 2 (1996): 233–43. http://dx.doi.org/10.1017/s0022029900031733.

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SummaryPreparation, physicochemical characterization and stability of iron-supplemented caseins were studied. When ferrous iron (final concentrations of 0·25, 0·5, 1·0 and 1·5 mM) was added to sodium caseinate (final casein concentration 25 g/l), iron binding to caseins was complete. In parallel, an increase in absorbance at 280 nm, a decrease in fluorescence intensity, modifications of reversed-phase HPLC profile, a decrease in pH and an increase in free sodium concentration were observed. Moreover, no release of iron from iron-casein complexes was found between pH 6·5 and 3·7 or after heat t

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Serdar, Maja, and Zorka Knežević. "Determination of Artificial Sweeteners in Beverages and Special Nutritional Products Using High Performance Liquid Chromatography." Archives of Industrial Hygiene and Toxicology 62, no. 2 (2011): 169–73. http://dx.doi.org/10.2478/10004-1254-62-2011-2084.

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Determination of Artificial Sweeteners in Beverages and Special Nutritional Products Using High Performance Liquid ChromatographyThis paper presents two high performance liquid chromatographic (HPLC) methods used for the separation and determination of artificial sweeteners aspartame, acesulphame K, sodium saccharin, and sodium cyclamate in beverages and special nutritional products (special food intended for specific population groups). All four compounds are soluble in aqueous solutions and can easily be separated and determined by HPLC with a diode array detector (DAD). The first method inv

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Savić, Ivana, Goran Nikolić, and Ivan Savić. "Quantitative analysis of sodium picosulfate in the presence of its alkaline degradation product." Macedonian Journal of Chemistry and Chemical Engineering 28, no. 2 (2009): 151. http://dx.doi.org/10.20450/mjcce.2009.204.

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A new procedure for the analytical control of a pharmaceutical formulation by high performance liquid chromatographic (HPLC) is proposed. It allows the simultaneous determination of the major compounds in the formulation of the active compound (sodium picosulfate) and the degradation product (impurity), which slowly degrades by hydrolysis with different concentrations of sodium hydroxide, at different temperatures. Separation of sodium picosulfate from the degradation product was performed using the ZORBAX Eclipse XDB C-18 column, with a mobile phase consisting of phosphate buffer (pH = 7) : a

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Vertiprakhov, Vladimir, Alena Grozina, Vladimir Fisinin, Natalya Ovchinnikova, and Anatoly Bittirov. "Impact of various reagents during blood collection from poultry to analyze morpho-biochemical indicators." E3S Web of Conferences 262 (2021): 02009. http://dx.doi.org/10.1051/e3sconf/202126202009.

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The work provides experimental data on the impact of anticoagulants (K3 - EDTA, 3.8% sodium citrate and lithium heparin) and coagulation activator on morpho-biochemical indicators in the blood samples of broiler chickens of cross-selection of Agricultural Center “Smena” at the age of 35 days. The studies were carried out with the use of semi-automatic flow analyzer Sinnowa BS-3000P (SINNOWA Medical Science & Technology Co., Ltd, China) and veterinary automatic blood analyzer DF-50 by Dymind Biotech (PRC) with the use of original reagents. The results showed that the most optimal reagent fo

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Gorchakov, Eduard V., Darya O. Perevezentseva, Elena A. Vaitulevich, and Oksana V. Dubinina. "Aspects of improving metrological characteristics of a sensor based on palladium nanoparticles for methionine determination." Bulletin of the Tomsk Polytechnic University Geo Assets Engineering 336, no. 1 (2025): 70–79. https://doi.org/10.18799/24131830/2025/1/4763.

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Relevance. The need to accurately determine the concentration of methionine in various biogeochemical samples. This amino acid serves as a precursor for the biosynthesis of proteins and peptides, as well as a donor of methyl groups, making it an essential participant in numerous biochemical processes, including cysteine synthesis. Additionally, methionine can be found in certain proteins, such as casein. Methionine is a widely used pharmacological drug that has a lipotropic effect and a positive impact on liver function. It enhances the synthesis of phospholipids, choline, and lecithin, as wel

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Schots, J., H. De Raeve, A. Boeyckens, V. Umbrain, F. Verbeek, and F. K. Gorus. "Method-Dependent Differences in Apparent Sodium Concentrations in Plasma after Exchange Transfusions with Citrated Blood." Clinical Chemistry 38, no. 4 (1992): 558–62. http://dx.doi.org/10.1093/clinchem/38.4.558.

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Abstract Shortly after exchange transfusions (n = 7) with citrate-dextrose-phosphate (CDP)-treated blood, but not after regular transfusions (n = 9), sodium concentrations in plasma were significantly and paradoxically lower (3-10 mmol/L) by Ektachem 700 XR determination [with use of electrolyte reference fluid (ERF) generation 00] than by flame photometry. Similar between-method differences could also be generated by in vitro supplementation of plasma pools with CDP solution, with trisodium citrate, or to a lesser extent with Na2HPO4. For four potentiometric methods the analytical recovery of

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Choudhury, Priyabati, Smriti Roy, Lopamudra Adhikari, and Sovan Pattanaik. "EFFECT OF SOLVENTS IN CHROMATOGRAPHIC DETERMINATION OF SILDENAFIL CITRATE IN MARKETED FORMULATION." INDIAN DRUGS 57, no. 01 (2020): 72–75. http://dx.doi.org/10.53879/id.57.01.11898.

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Chromatography is the procedure for analysing a multicomponent mixture of trace, minor or major constituent by separaationinto its individual fractions.For the analytical determination of sildenafil in pharmaceutical dosages forms an expeditious & sensitive RP-HPLC method is described.The mobile phase composition for chromatographing sildenafil was acetonitrile: methanol: water(60:25:15, V/V/V) with a flow rate of 1mL/min using C18 column. The internal standard selected was racecadotril and its eluents were observed at 217nm. The retention time was 4.919 min for the drug. Between 5-200μg/m

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Aksu Dönmez, Özlem, Şule Dinç-Zor, Bürge Aşçı, and Abdürrezzak E. Bozdoğan. "Quantitative Analysis of Food Additives in a Beverage using High Performance Liquid Chromatography and Diode Array Detection Coupled with Chemometrics." Journal of AOAC INTERNATIONAL 103, no. 3 (2020): 779–83. http://dx.doi.org/10.1093/jaocint/qsz009.

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Abstract Background In many countries, the levels of synthetic food additives causing harm to humans have been determined and their use has been controlled by legal regulations. Sensitive, accurate and low-cost analysis methods are required for food additive determination. Objective In this study, a fast high performance liquid chromatography-diode array detection (HPLC-DAD) analytical methodology for quantification of sodium benzoate, potassium sorbate, ponceau 4R, and carmoisine in a beverage was proposed. Methods Partial least squares (PLS) and principal component regression (PCR) multivari

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Swapna B., Chandrasekhar K B, Madhuri D., and Sumathi G. "Biological Synthesis and Characterisation of Silver Nanoparticles of Zingiber officinalis and Evaluation of its Biological Activity." International Journal of Research in Pharmaceutical Sciences 13, no. 4 (2022): 396–402. http://dx.doi.org/10.26452/ijrps.v13i4.3833.

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Ginger (Zingiber officinale) belongs to Zingiberaceae family is one of the famous spices all over the world. It is a perennial creeping plant with long leaves, yellow green flowers and thick tuberous rhizome. Silver nanoparticles’ potential uses in Green Chemistry have received attention. The current study focuses on the rapid biological production of silver nanoparticles using different plant materials and characterizations using UV-visible spectrophotometry, IR, SEM, and HPLC investigations. Within 15 minutes of adding sodium carbonate, an aqueous extract of dried Zingiber officinalis rhizom

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48

Daly, Rebecca, Sonal Mehra, Amrita Dhutia, et al. "Hirudin anticoagulation allows more rapid determination of P2Y12 inhibition by the VerifyNow P2Y12 assay." Thrombosis and Haemostasis 109, no. 03 (2013): 550–55. http://dx.doi.org/10.1160/th12-10-0718.

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SummaryVerifyNow (VN) P2Y12 is a point-of-care assay used to assess response to P2Y12 inhibitors. Sodium citrate (citrate) is the standard anticoagulant used for this assay but requires a pre-incubation period. Hirudin is an alternative anticoagulant for platelet function studies that maintains physiological divalent cation levels. We investigated whether hirudin anticoagulation might allow more rapid testing of P2Y12 inhibition at the time of percutaneous coronary intervention (PCI). Blood was collected from the arterial sheath of aspirin-treated patients undergoing elective, urgent or emerge

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Oza, Chinmaykumar. "Method Development and Validation of Assay of Docusate Sodium in Docusate Sodium Liquid Filled Capsules by HPLC Method." International Journal of Advanced Pharmaceutical Sciences and Research 5, no. 2 (2025): 14–21. https://doi.org/10.54105/ijapsr.a4067.05020225.

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Although the USP monograph has provided the method for the determination of % Assay of Docusate sodium in Docusate sodium capsules, it could not produce precise and accurate results in the existing laboratory environment. Thus, the method for the Determination of Assay for Docusate Sodium in Soft Gelatin Capsules was developed on high‐performance liquid Chromatographic (HPLC) using Certified Reference Material Pharmaceutical Secondary Standard. A reversed phase chromatographic method was developed with a reversed‐phase column to quantify the potency of docusate sodium from Soft Gelatin liquid

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KRISHNAIAH, Yellela S. R., Tatikonda K. MURTHY, Dannana G. SANKAR, and Valiveti SATYANARAYANA. "The Determination of Mosapride Citrate in Bulk Drug Samples and Pharmaceutical Dosage Forms Using HPLC." Analytical Sciences 18, no. 11 (2002): 1269–71. http://dx.doi.org/10.2116/analsci.18.1269.

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