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Dissertations / Theses on the topic 'Spike protein'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Mund, Thomas. "Biochemische und molekularbiologische Charakterisierung von Spike, einem neuen BH3-Domänen Protein." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-14456.

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2

Chan, Che-man, and 陳志敏. "Functional study of spike protein of a novel human coronavirus HKU1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41896932.

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3

Chan, Che-man. "Functional study of spike protein of a novel human coronavirus HKU1." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41896932.

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4

Du, Lanying. "Functional study of the spike protein of severe acute respiratory syndrome coronavirus." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38602362.

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5

Andersson, Allan. "Nitrogen redistribution in spring wheat : root contribution, spike translocations and protein quality /." Alnarp : Dept. of Crop Science, Swedish Univ. of Agricultural Sciences, 2005. http://epsilon.slu.se/200510.pdf.

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6

Du, Lanying, and 杜蘭英. "Functional study of the spike protein of severe acute respiratory syndrome coronavirus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38602362.

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7

Hesse, Martina [Verfasser]. "Characterization of the binding properties of the Avian Coronavirus spike protein / Martina Hesse." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2015. http://d-nb.info/1073850358/34.

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8

Yeung, Yin-shan. "Molecular characterization of apoptosis induced by severe acute respiratory syndrome coronavirus spike protein." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38302366.

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9

Yeung, Yin-shan, and 楊燕珊. "Molecular characterization of apoptosis induced by severe acute respiratory syndrome coronavirus spike protein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38302366.

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10

Lam, Pui-yi, and 林佩儀. "Characterization of neutralizing and receptor binding activities in human coronavirus NL63 spike protein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41896865.

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11

Lam, Pui-yi. "Characterization of neutralizing and receptor binding activities in human coronavirus NL63 spike protein." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41896865.

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12

Schweers, Nicholas Joseph. "Genetic Analysis of a Microvirus Major Spike Protein: A C-Terminal Region Critical for Assembly." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321950.

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13

Law, Ka-man. "Vaccine development against the severe acute respiratory syndrome-coronavirus (SARS-CoV) using SARS-CoV spike protein." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B36774480.

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14

Law, Ka-man, and 羅嘉敏. "Vaccine development against the severe acute respiratory syndrome-coronavirus (SARS-CoV) using SARS-CoV spike protein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B36774480.

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15

Niehage, Christian. "Label-free and spike-in standard-free mass spectrometry in the proteomic analysis of plasma membrane proteins and membrane-associated protein networks." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-134966.

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Mass spectrometry is the primary technology of proteomics. For the analysis of complex proteomes, protein identities and quantities are inferred from their peptides that are generated by cleaving all proteins with the endopeptidase trypsin. But there is one major disadvantage that is due to biophysical differences, different peptides cause different intensities. Miscellaneous approaches have been developed to circumvent this problem based on the chemical or metabolic introduction of heavy stable isotopes. This enables to monitor protein abundance differences of two or more samples on the same

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16

Dashan, Li. "Factors affecting the membrane fusion-inducing capacity of the spike protein of avian infectious bronchitis coronavirus (IBV)." Thesis, Royal Veterinary College (University of London), 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522192.

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17

Gierer, Stefanie [Verfasser], Stefan [Akademischer Betreuer] Pöhlmann, and Martin [Akademischer Betreuer] Oppermann. "Functional analysis of the MERS-coronavirus spike protein / Stefanie Gierer. Gutachter: Stefan Pöhlmann ; Martin Oppermann. Betreuer: Stefan Pöhlmann." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1054821925/34.

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18

Song, Fei. "Characterization of recombinant Modified Vaccinia virus Ankara for delivery of Middle East Respiratory Syndrome Coronavirus spike protein antigens." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-172469.

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19

Li, Kam-bun Keith, and 李錦彬. "Experimental characterization of the severe acute respiratory syndromecoronavirus spike protein and angiotensin: converting enzyme 2 towards the viral infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39707489.

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20

Li, Kam-bun Keith. "Experimental characterization of the severe acute respiratory syndrome coronavirus spike protein and angiotensin converting enzyme 2 towards the viral infection /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39707489.

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21

Balaji, Chandra Sekhar Sinhadri [Verfasser]. "Expression and characterization of spike protein complexes Gp2/Gp3/Gp4 and Gp5/M of the Arterivirus / Sekhar Sinhadri Balaji Chandra." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1071843435/34.

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22

CIMINO, Anna Rita. "Amphiphilic and ganglioside-binding properties of SARS CoV-2 Spike protein variants dissected by charge shift electrophoresis in deterged solution." Doctoral thesis, Università degli studi del Molise, 2022. https://hdl.handle.net/11695/115828.

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The data contained in this thesis provide a demonstration of the amphiphilic properties of SARS-2-S, the Spike glycoprotein of SARS-CoV-2, as well as of its  (B.1.617.2, delta) and  (B.1.1.529, omicron) variants, obtained by charge shift electrophoresis (CSE) in detergent solution. Wild-type,  and  SARS-2-S presented distinct amphiphilic properties, reflecting their ability to participate in the formation of mixed TX-100/DOC and TX-100/CTAB micelles of homogeneous size. The SARS-2-S  plus variant exhibited a more limited amphiphilicity in TX/DOC, possibly reflecting its propensity for TX-

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23

Lam, Chun-yip, and 林俊業. "Comparative molecular analysis of the binding between severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein andangiotensin converting enzyme 2(ACE2)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557017.

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24

Lam, Chun-yip. "Comparative molecular analysis of the binding between severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein and angiotensin converting enzyme 2(ACE2)." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557017.

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25

Song, Fei [Verfasser], and Gerd [Akademischer Betreuer] Sutter. "Characterization of recombinant Modified Vaccinia virus Ankara for delivery of Middle East Respiratory Syndrome Coronavirus spike protein antigens / Fei Song. Betreuer: Gerd Sutter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/105491477X/34.

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26

Tscherne, Alina [Verfasser], and Gerd [Akademischer Betreuer] Sutter. "Characterization of a recombinant Modified Vaccinia virus Ankara expressing the severe acute respiratory syndrome virus 2 spike protein / Alina Tscherne ; Betreuer: Gerd Sutter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1239557264/34.

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27

GULOTTA, Maria Rita. "Computational methodologies applied to Protein-Protein Interactions for molecular insights in Medicinal Chemistry." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/479127.

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In living systems, proteins usually team up into “molecular machinery” implementing several protein-to-protein physical contacts – or protein-protein interactions (PPIs) – to exert biological effects at both cellular and systems levels. Deregulations of protein-protein contacts have been associated with a huge number of diseases in a wide range of medical areas, such as oncology, cancer immunotherapy, infectious diseases, neurological disorders, heart failure, inflammation and oxidative stress. PPIs are very complex and usually characterised by specific shape, size and complementarity. The pr

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28

Niehage, Christian [Verfasser], Bernard [Akademischer Betreuer] Hoflack, and Henning [Akademischer Betreuer] Urlaub. "Label-free and spike-in standard-free mass spectrometry in the proteomic analysis of plasma membrane proteins and membrane-associated protein networks / Christian Niehage. Gutachter: Bernard Hoflack ; Henning Urlaub. Betreuer: Bernard Hoflack." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://d-nb.info/1068445378/34.

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29

Bonnin, Ariane. "Caractérisation de la protéine S du coronavirus humain 229E." Thesis, Lille 2, 2018. http://www.theses.fr/2018LIL2S007/document.

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Le coronavirus humain 229E (HCoV-229E) est responsable de rhumes mais peut entraîner de graves complications respiratoires chez les personnes âgées ou atteintes d’une maladie Chronique. Les coronavirus sont des virus enveloppés avec un génome à ARN positif simple brin. Trois protéines virales sont ancrées dans l'enveloppe virale : la protéine spike (S), la protéine de membrane (M) et la protéine d’enveloppe (E). Les protéines M et E sont impliquées dans l'assemblage viral et la sécrétion. La protéine S s'assemble en trimères à la surface des virions et joue un rôle-clé dans l’entrée du virus d

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30

Reinke, Lennart Michel [Verfasser], Michael [Akademischer Betreuer] Winkler, Lutz Prof [Gutachter] Walter, Carsten [Gutachter] Lüder, and Thomas [Gutachter] Meyer. "Identifikation und funktionelle Charakterisierung von TMPRSS2-Spaltstellen im Spike-Protein des SARS-Coronavirus / Lennart Michel Reinke ; Gutachter: Lutz Prof Walter, Carsten Lüder, Thomas Meyer ; Betreuer: Michael Winkler." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/1131875621/34.

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31

Stephan, Thomas Min [Verfasser], Silke [Akademischer Betreuer] Rautenschlein, Georg [Akademischer Betreuer] Herrler, and Egbert [Akademischer Betreuer] Mundt. "Molecular characterization of the spike protein of an avian infectious bronchitis virus (IBV) with cell culture tropism and identification of the underlying determinants / Thomas Min Stephan ; Silke Rautenschlein, Georg Herrler, Egbert Mundt." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2019. http://d-nb.info/1202774873/34.

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32

JACOVETTI, Reginaldo. "Uso de milheto como silagem comparado a gramíneas tradicionais : aspectos quantitativos, qualitativos e econômicos." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tde/866.

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Made available in DSpace on 2014-07-29T15:07:37Z (GMT). No. of bitstreams: 1 Dissertacao Reginaldo Jacovetti.pdf: 647335 bytes, checksum: 8f3872d3d6f0b90e4cc497b5edf0f833 (MD5) Previous issue date: 2012-02-27<br>The Brazilian farmers make use of vary forages plants to be conserved in the ensilage form, for supplementation of the animals in the period of fall of pastures. However, forage millet presents as a possible alternative, in view of its potential of production and possibility of culture as off-season cultivation. The objective of this work was to evaluate the production and the morph-

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33

Wu, Shang-Rung. "Activation of the spike proteins of alpha- and retroviruses." Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-736-8/.

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34

Izadkhasti, Sousan. "Generation of recombinant infectious bronchitis viruses with chimaeric spike proteins." Thesis, Royal Veterinary College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441413.

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35

Winter, Christine. "Charakterisierung des IBV-Spike-Proteins Bindungseigenschaften und Lokalisation in eukaryotischen Zellen /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=978261763.

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36

Mair, Caroline. "Membrane fusion mediated by the influenza virus hemagglutinin." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17217.

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Der Eintritt von Influenza A Viren in Wirtszellen erfolgt anhand des Hämagglutinin (HA) Proteins. Neueste Entwicklungen zielen darauf ab, die fusionsinduzierende Konformations-änderung des HA und damit die Freisetzung des viralen Genoms in die Wirtszelle zu inhibieren. Der Fusionsprozess ist pH-abhängig da nur bei einem niedrigen pH-Wert (~5.0-6.0) die Protonierung bestimmter Reste innerhalb des HA eine Konformationsänderung, und somit die Membranfusion, auslöst. Die Identifizierung von konservierten, titrierbaren Resten und die Aufklärung der Strukturveränderungen im HA ermöglichen eine gezie

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37

Magder, Ilana. "The importance of a radial spoke protein in flagellar motility /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31266.

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The aim of our investigation was to gain insight on the regulation of flagellar movement, at the axonemal level. In our laboratory a panel of monoclonal antibodies (MoAbs) has been produced against the axoneme of the biflagellated algae, Chlamydomonas reinhardtii, a well-characterized model for the study of flagellar movement. Of these MoAbs, L2H12 has been selected, because it has a potent inhibitory effect on the motility of de membranated-reactivated flagella of Chlamydomonas cells. Using video micrography, we demonstrated that low concentrations of L2H12 cause a progressive decrease in the

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38

Wu, Qian. "Involvement of Cdk5/p35 in EphB2-dependent dendritic spine development /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BICH%202008%20WUQ.

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39

Salomon, Steven. "Expression of the formin Daam 1 in pyramidal neurons of the hippocampus affects spine morphology." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98789.

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Formins, also known as formin homology (FH) proteins, are involved in a wide range of actin-mediated processes. The Diaphanous-related formin Daam1 (Dishevelled-associated activator of morphogenesis) interacts with the PDZ domain protein Dishevelled, and is required to establish planar cell polarity in Xenopus. Through a yeast two-hybrid screen, I characterized a PDZ-mediated interaction between the C-terminus of Daam1 and the PDZ domains 456 of GRIP1. In dissociated rat hippocampal cultures, Daam1 expression was seen throughout the soma and dendrites in a punctate pattern. Furthermore, co-sta

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40

Robertson, Holly Rochelle. "Regulation of dendritic spine structure and function by A-kinase anchoring protein 79/150 /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 135-162). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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41

Jiang, Ming. "Multimerization and interaction with GKAP regulate shank protein folding and delivery to dendritic spine /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20JIANG.

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42

Gelhaus, Sandra [Verfasser]. "Analyse der zytoplasmatischen Domäne eines Alphacoronavirus Spike-Proteins und ihrer Funktion beim Zusammenbau von Viruspartikeln / Sandra Gelhaus." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2014. http://d-nb.info/1054311455/34.

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43

Wang, Lili. "The role of synaptopodin for the diffusion of membrane protein in the dendritic spine neck." Thesis, Paris, Ecole normale supérieure, 2015. http://www.theses.fr/2015ENSU0021/document.

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Au sein des synapses comme dans les régions extra synaptiques, la diffusion latérale joue un rôle critique dans la densité membranaire des récepteurs. En face des zones actives, l’accumulation de récepteurs détermine en particulier l’efficacité de la transmission synaptique. Il est important de comprendre les paramètres cellulaires qui jouent sur l’accès au compartiment synaptique, qu’ils soient d’origine moléculaires ou morphologiques. Dans les synapses excitatrices, la tige de l’épine dendritique se comporte comme une barrière à la diffusion. Cette barrière pourrait être fonction de la longu

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44

Yong, Mostyn R. "Characterisation of Polycaprolatone-Based Scaffold Plus Recombinant Human Morphogenetic Protein - 2 (RHBMP-2) in an Ovine Thoracic Spine Model." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/64093/1/Mostyn_Yong_Thesis.pdf.

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This thesis represents a step forward in the development of a pre-clinical model investigating a suitable substitute for host bone for use in human spinal fusion. By way of an animal model, it examines the biological performance of a novel bone graft substitute comprised of a combination of a custom-designed biodegradable material and biologics.

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45

Martynyuk, Nataly. "Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/287938.

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Rho GTPases and their regulators such as guanosine exchange factors (GEFs) and GTPase activating proteins (GAPs) represent an important class of molecules controlling dendritic spine plasticity. Although they are typically described as cytoskeletal modulators, roles for the GTPases in endocytosis and cell polarity establishment have also been defined. The neuronal proteins a1- and a2-chimaerins belong to a group of Rac and Cdc42 GAPs that inactivate these GTPases; in addition to a GAP domain, the a-chimaerins share a phosphokinase C (PKC)-like C1 domain but have distinct N-terminal domains (NT

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46

SECCI, PIETRO PAOLO. "La separazione dalla prole reverte le modificazioni nell'espressione di BDNF, proteina Arc, spine dendritiche, LTP e neurogenesi osservate durante la gravidanza e dopo il parto." Doctoral thesis, Università degli Studi di Cagliari, 2011. http://hdl.handle.net/11584/266279.

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La gravidanza, il parto e il periodo post partum costituiscono particolari condizioni fisiologiche durante le quali il cervello femminile è sottoposto a modificazioni funzionali e morfologiche necessarie per l’insorgenza e il mantenimento del comportamento materno. Il BDNF (Brain Derived Neurotrofic Factor), così come la proteina Arc (Activity-Regulated Cytoskeletal), costituisce un mediatore chiave della plasticità neuronale e la sua azione a lungo termine ha un ruolo importante nell’apprendimento, memoria, comportamento affettivo ed emozionale (1); entrambi inoltre sono in grado di regolar

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47

Chazeau, Anael. "Rôle de l’organisation du cytosquelette d’actine branché et des adhésions N-cadhérine dans la dynamique des épines dendritiques." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21967/document.

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Les épines dendritiques sont de petites protrusions post-synaptiques présentant des changements morphologiques corrélés avec la plasticité synaptique. Elles ont pour origine les filopodes dendritiques qui s’élargissent lors du contact avec l’axone. Ces changements morphologiques impliquent une grande variété de molécules dont des protéines associées à l’actine et des protéines d’adhésion. Cependant, comment ces différentes protéines sont coordonnées dans le temps et l’espace est encore largement méconnu. De plus, les techniques de microscopie conventionnelle ne permettent pas d’étudier l’organ

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48

Jia-Juan, Wu, and 吳嘉娟. "Characterization of Protein-Protein Interactions between Spike (S) Protein and other Structural Proteins." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/39023440796619056707.

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碩士<br>國防醫學院<br>微生物及免疫學研究所<br>93<br>Severe acute respiratory syndrome (SARS) is a new emerging disease that causes worldwide epidemic since 2002. So far, there is no effective vaccine or specific anti-viral drug available for SARS. It has been reported that the etiology of this new disease was a virus, which belongs to coronaviruses and thus was named as SARS-associated coronavirus (SARS-CoV). The coronavirus Spike (S) protein, which is important for virion budding and formation of a corona-like structure, is the key player in virion assembly and envelope organization. Thus, this thesis was dec

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49

chung, sun ray, and 孫瑞強. "The prediction of SARS_CoV spike protein binding CD4+T cellThe prediction of SARS_CoV spike protein binding CD4+T cell." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/25124313906864082909.

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碩士<br>臺中健康暨管理學院<br>生物資訊研究所<br>93<br>To obtain the information of ligand-receptor binding between the S protein of SARS_CoV and CD4, identify the possible interacting domains or motifies related to binding sites, and provide clues for studying the functions of SARS proteins and designing anti-SARS drugs and vaccines. We used the homology search, and multi-sequence alignment were used to predict CD4 related interacting domains and binding sites in the S protein of SARS_CoV. Molecular modeling and using AutoDock methods were employed to address the interaction feature between CD4 and S protein

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50

Gierer, Stefanie. "Functional analysis of the MERS-coronavirus spike protein." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5F42-4.

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Zehn Jahre nach dem Ausbruch des Severe Acute Respiratory Syndrome Coronavirus, SARS-CoV, ist ein neues Betacoronavirus, das Middle East Respiratory Syndrome Coronavirus, MERS-CoV, auf der arabischen Halbinsel entdeckt worden. Seine anhaltende Ausbreitung stellt eine Bedrohung für die öffentliche Gesundheit dar. Das Spike (S) Protein der Coronaviren vermittelt den viralen Eintritt in Wirtszellen und bestimmt wesentlich den viralen Tropismus und die virale Pathogenese. Das Verständnis der Determinanten des MERS-CoV Spike (MERS-S)-vermittelnden Eintritts in Zellen könnte daher wichtige Einblicke

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