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Journal articles on the topic 'Splenomegaly (Enlarged liver)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

K. Al-Malaak, Maha. "Histopathological changes on Splenomegaly induced in Experimental rats Wistar albino." AL-QADISIYAH MEDICAL JOURNAL 10, no. 18 (2017): 50–62. http://dx.doi.org/10.28922/qmj.2014.10.18.50-62.

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This study was aimed to evaluate histopathological changes in experimental rats with induced splenomegaly and liver fibrosis by administering thioacetamid (TAA). Liver fibrosis was clearly noticed in all experimental rats after intraperitoneally injected with a dose (200mg/kg) body weight for 8 weeks ,while control rats injected with buffered saline.The body , spleen and liver weight were recorded , also ratio of liver and spleen per body weight was estimated.Macroscopical changes including (colour, size, congested, signs of fibrosis, irregularity, nature of surface) regarded to liver and sple

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Song, Xie, Hong-Qiang Chen, Yu-Xin Chen, et al. "Individualized Management of Hepatic Diseases in Hereditary Hemorrhagic Telangiectasia." American Surgeon 77, no. 3 (2011): 281–85. http://dx.doi.org/10.1177/000313481107700314.

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Liver involvement in patients with hereditary hemorrhagic telangiectasia (HHT) has not been fully characterized in China. The clinical manifestations, imaging studies, results of treatment in six patients and symptomatic liver involvement were analyzed. Patients included three women and three men with age from 35 to 62 years old. Two patients presented with shortness of breath, one patient with anemia and splenomegaly, and one with chronic gastrointestinal bleeding; the remaining two were asymptomatic. CT and CT angiography (CTA) showed arterioportal and arteriovenous shunting in liver. CTA sh

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Jehangir, Khan, Munir Waqas, Tarin Khan Bakht, Ahmad Zaheer, Ahmad Shams Waqas, and Khan Asar. "Dengue outbreak 2013: Clinical profile of patients presenting at DHQ Burner and THQ Shangla, Khyber Pakhtunkhwa, Pakistan." Biohelikon 3 (January 1, 2015): 1–4. https://doi.org/10.5281/zenodo.816342.

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We evaluated the clinical features, disease severity, laboratory findings and outcome of serologically confirmed cases of Dengue fever in Patients during the recent outbreak in two districts (Buner & Shangla) in 2013, Khyber Pkhtunkhwa, Pakistan. We encountered 320 cases of Dengue fever during 5 months period (July to November, 2013). The dengue infection rate in females (180: 56%.2) was higher as compared to males (140: 43.8%). The dengue infections were more frequently seen in the post-monsoon season than in the monsoon period. The death ratio in the overall weighted prevalence was 0%. A

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Khurana, Ritika, Anju Aggarwal, Aashima Dabas, and Natasha Gupta. "Massive hepatomegaly in a neonate: an unusual cause." International Journal of Contemporary Pediatrics 4, no. 1 (2016): 274. http://dx.doi.org/10.18203/2349-3291.ijcp20164618.

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A female neonate presented with progressive abdominal distension. Liver was palpable, 11 cm below costal margin and a spleen of 10 cm. USG abdomen revealed massive hepatomegaly with multiple nodules in liver, kidney size and texture being normal. Contrast enhanced CT scan of the abdomen was suggestive of enlarged multinodular liver with splenomegaly. Liver biopsy revealed replacement of liver architecture by small rounded cells, which were positive for synaptophysin and S100 stains suggestive of neuroblastoma. A repeat abdominal radiological evaluation revealed a small 2 x 1 cm mass in left su

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OKADA, S., K. TAGAWA, R. WADA, Y. YAGUCHI, Y. KASHIMA, and A. NISHIMORI. "Enzootic bovine leukosis accompanied by splenomegaly in an 8-month-old calf." Journal of the Hellenic Veterinary Medical Society 71, no. 1 (2020): 2080. http://dx.doi.org/10.12681/jhvms.22969.

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In this report, an 8-month-old calf (crossbred, Holstein × Japanese Black) developed fever and accompanied abomasum displacement. Blood chemical test showed remarkably high values of white blood cell count and heteromorphic lymphocytes. In pathological appraisal, enlarged splenomegaly and swelling of the lymph nodes were observed. Histopathological examination revealed invasion of tumor cells derived from B1 cells into systemic lymph nodes, liver and spleen. The provirus loads of bovine leukemia virus (BLV) was 1,439 copies per 10 ng DNA by using real time PCR. In conclusion, this case was dia

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Dehghani, Seyed Mohsen, Amir Saeidi, Farzaneh Nejati, et al. "Clinical and Paraclinical Findings in Children With Congenital Hepatic Fibrosis: A Single Center 10-Year Study." Hospital Practices and Research 5, no. 2 (2020): 42–46. http://dx.doi.org/10.34172/hpr.2020.09.

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Background: Congenital hepatic fibrosis (CHF) is an autosomal hereditary disorder affecting the porto-biliary system. It is a rare hereditary disorder often presenting in childhood or adolescence with hepatomegaly, splenomegaly, and gastrointestinal bleeding. A timely diagnosis of organomegalies by sonography can prevent esophageal varices. Liver transplantation is now the only cure for CHF. Objectives: The current study aimed to determine clinical and paraclinical findings in patients diagnosed with CHF from 2008 to 2017. Methods: This was a descriptive cross-sectional study of all children &

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Djordjevic, Jelena, Petar Svorcan, Dusica Vrinic, and Branka Dapcevic. "Splenomegaly and thrombocytopenia in patients with liver cirrhosis." Vojnosanitetski pregled 67, no. 2 (2010): 166–69. http://dx.doi.org/10.2298/vsp1002166d.

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Backgroud/Aim. Splenomegaly is a frequent finding in patients with liver cirrhosis and portal hypertension and may cause hypersplenism. The occurrence of thrombocytopenia in those patients can be considered as an event with multiple etiologies. Two mechanisms may act alone or synergistically with splenic sequestration. One is central which involves either myelosuppression because of hepatitis viruses or the toxic effects of alcohol abuse on the bone marrow. The second one involves the presence of antibodies against platelets. It also depends upon the stage and etiology of liver disease. The ai

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Valentine, B. A., and S. P. Mcdonough. "B-Cell Leukemia in a Sheep." Veterinary Pathology 40, no. 1 (2003): 117–19. http://dx.doi.org/10.1354/vp.40-1-117.

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Necropsy examination was performed on an 8.5-year-old Finnish ewe euthanatized because of progressive respiratory distress, cachexia, and weakness. Significant postmortem findings included a diffusely enlarged, dark-red friable liver, mild splenomegaly, and mild mesenteric lymphadenopathy. Examination of multiple tissue sections revealed intravascular atypical mononuclear cells in all tissues examined, with a leukemic pattern of infiltration of mesenteric lymph nodes, liver, lung, and spleen. Neoplastic cells were positive for CD79a and negative for CD-3, BLA.36, and CD68 leukocytic markers. T

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9

Curovic Rotbain, Emelie, Dennis Lund Hansen, and Henrik Frederiksen. "The Data Quality of Splenomegaly ICD-10 Diagnoses in a Population-Based Hospital Discharge Registry: A Preliminary Analysis." Blood 126, no. 23 (2015): 5571. http://dx.doi.org/10.1182/blood.v126.23.5571.5571.

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Abstract Background Splenomegaly is a common finding in general medical patients. The cause of splenomegaly is often found outside the spleen and therefore an extensive diagnostic medical work-up is frequently required. There is very little data on the distribution of causal diagnoses and, to the best of our knowledge, accurate data on the risk of hematological malignancies, hepatic diseases and storage diseases among patients with splenomegaly have never been reported. The aim of this pilot study is to investigate the validity of the splenomegaly ICD-10 diagnoses, in order to ascertain if a n

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10

Jakobovich, E., B. Koplewitz, E. Marva, and E. Granot. "Yersinia enterocoliticaInfection Simulating Lymphoproliferative Disease, after Liver Transplant." Case Reports in Transplantation 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/923058.

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We describe a 14-year-old girl, who was 13 y after liver transplantation for biliary atresia with an unremarkable postoperative course. She presented with fever of up to 40°C, extreme fatigue, malaise, anorexia, and occasional vomiting. On physical examination the only finding was splenomegaly. Lab results showed hyperglobulinemia and an elevated sedimentation rate. Liver function tests were normal except for mild elevation ofγGTP. Abdominal U/S and CT demonstrated an enlarged spleen with retroperitoneal and mesenteric lymph nodes enlargement. An exhaustive evaluation for infectious causes, au

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Gomes, Natália Borges Nunes, Ulysses S. Torres, Gabriella Souza e. Silva, Perla Oliveira Schulz Mamone, Maria Lucia Cardoso Gomes Ferraz, and Giuseppe D’ippolito. "Magnetic resonance imaging findings in autoimmune hepatitis: how frequent and reproducible are they?" Radiologia Brasileira 56, no. 6 (2023): 308–16. http://dx.doi.org/10.1590/0100-3984.2023.0044.

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Abstract Objective: To determine the frequency and interobserver reproducibility of the magnetic resonance imaging (MRI) features considered diagnostic for autoimmune hepatitis. Materials and Methods: Two abdominal radiologists, blinded to pathology data, reviewed the MRI examinations of 20 patients with autoimmune hepatitis, looking for liver enhancement, lymphadenopathy, portal hypertension, and chronic liver disease. The pattern of liver fibrosis was categorized as reticular, confluent, or mixed. Interobserver agreement was assessed by calculating intraclass correlation coefficients and kap

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12

Beniwal, Rajveer S., Akhilesh Rao, Yayati Pimpalwar, and Prabhakar Teli. "Ultrasound of abdomen in acute viral hepatitis and its role as a prognostic marker." International Journal of Research in Medical Sciences 7, no. 12 (2019): 4673. http://dx.doi.org/10.18203/2320-6012.ijrms20195536.

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Background: To assess the extent of Ultrasound (USS) abdomen findings in acute viral hepatitis and further assess the role of USS as a prognostic marker.Methods: From May 2013 to September 2016, a total of 220 patients of acute Enterogenic viral hepatitis were studied by routine USS within first seven days of onset of symptoms, followed by routine USS between 10 to 15 days and follow up scan after 12 weeks. Only patients with acute Enterogenic viral hepatitis (Hepatitis A and Hepatitis E) were included. All patients with chronic liver disease and other form of acute hepatitis i.e. Hepatitis B,

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Dantsev, V. V., R. D. Muchaidze, L. R. Levina, M. G. Spitsyn, V. S. Tokmakov, and G. S. Balasanyants. "The impact of the infection caused by hepatitis B and C on the characteristics of hepatotoxic reactions in tuberculosis patients." Tuberculosis and Lung Diseases 98, no. 7 (2020): 26–30. http://dx.doi.org/10.21292/2075-1230-2020-98-7-26-30.

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The objective of the study: to identify the specific parameters of hepatotoxic reactions in tuberculosis patients depending on the presence of hepatitis B and C markers in the blood. Subjects and methods. The state of the hepatobiliary system was studied in 107 HIV-negative patients with newly diagnosed infiltrative pulmonary tuberculosis in the destructive phase. The main group included 52 people with positive results of the tests for markers of viral hepatitis B and C, the comparison group included 55 people with negative results. The groups were compatible in age, volume of the lung tissue

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Hu, Shanshan, Cameron Marshall, Jocelyn Darby, Heinrich Korner, and Bruce Lyons. "TNF deficiency leads to splenomegaly during Cutaneous Leishmaniasis." Journal of Immunology 196, no. 1_Supplement (2016): 131.20. http://dx.doi.org/10.4049/jimmunol.196.supp.131.20.

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Abstract Cutaneous leishmaniasis in resistant C57BL/6 (B6.WT) mice is resolved spontaneously by Th-1 mediated production of TNF-α and IFN-γ, with consequent induction of inducible nitric oxide synthase. Intriguingly, C57BL/6 mice with a TNF gene knockout (B6.TNF−/−) show uncontrolled fatal infection involving the liver and spleen, which are the two main targets in visceral leishmaniasis. The exact role of TNF or specific mechanism, which is responsible for the fatal outcome of Leishmania infection in this gene-deficient mouse strain, is not yet understood. B6.TNF−/− mice spleen significantly e

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15

Potapenko, V. G., M. M. Antonov, N. V. Vinogradova, et al. "Hemophagocytic syndrome associated with leishmaniasis: case report." Oncohematology 17, no. 3 (2022): 89–97. http://dx.doi.org/10.17650/1818-8346-2022-17-3-89-97.

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Secondary hemophagocytic syndrome (sHLH) is a hyperinflammatory reaction which manifests with fever, cytopenia and organ damage. possible causes of sHLH include leishmaniasis. The article describes a clinical case of sHLH in patient with visceral leishmaniasis. A female 30 years old developed hectic daily fever up to 40 °C, pancytopenia, cytolytic syndrome, hyperferritin- and hypertriglyceridemia, immunoglobulin G to capsid antigens of the Epstein-Barr virus, enlarged liver and spleen a one and a half month after returning from Spain. based on the HLH-2004 and H-Score criteria, a sHLH was diag

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16

Al-Samman, A., K. Molnár, Cs Székely, and J. Reiczigel. "Reno-, hepato- and splenomegaly of common carp fingerlings (Cyprinus carpio L.) diseased in swimbladder inflammation caused by Sphaerospora renicola Dyková et Lom, 1982." Acta Veterinaria Hungarica 51, no. 3 (2003): 321–29. http://dx.doi.org/10.1556/avet.51.2003.3.7.

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The weight of internal organs (swimbladder, kidney, liver, spleen) in relation to the body weight was studied in common carp fingerlings divided into three groups on the basis of swimbladder appearance and microscopic examination of the kidney. The fish had been collected from different Hungarian fish farms at the time when swimbladder inflammation (SBI) usually occurs (in July and August). The first group comprised fish with severe signs of SBI and massive renal sphaerosporosis, the second group consisted of fish with milder swimbladder changes and/or kidney infection by a low number of Sphae

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17

Mehta, H. K., Mahima, ., RK Bagherwal, and R. Chaurasia. "Clinical and Ultrasonographic Alterations in Canine Babesiosis." INDIAN JOURNAL OF VETERINARY SCIENCES AND BIOTECHNOLOGY 15, no. 03 (2020): 30–31. http://dx.doi.org/10.21887/ijvsbt.15.3.8.

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Canine babesiosis is a worldwide tick borne disease. Dogs with fever, in appetence and enlarged lymph nodes were screened for the presence of haemoprotozoan parasites during the one year period of study at T.V.C.C., C.V.Sc., Mhow (M.P. , India ). Based on the stained peripheral blood smears examination, dogs were found to be affected with babesiosis. Clinical examination of the dogs revealed ticks over the body, highest frequency (75.00%) of petechial/epistaxis followed by ticks (72.22%) on the body, recumbency (69.44%), dullness (66.66%), dehydration (63.88%), pale mucous membrane (50.00%) .

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18

Pulpipat, Theeraporn, Visanu Boonyawiwat, Pattra Moonjit, et al. "Streptococcus agalactiae Serotype VII, an Emerging Pathogen Affecting Snakeskin Gourami (Trichogaster pectoralis) in Intensive Farming." Transboundary and Emerging Diseases 2023 (March 24, 2023): 1–13. http://dx.doi.org/10.1155/2023/1682047.

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Snakeskin gourami (Trichogaster pectoralis) is a freshwater fish species that is being increasingly cultivated in Southeast Asia. The expansion of farms and intensive farming practices has led to the unexplained mortality of snakeskin gourami and tremendous economic losses in many farms. We investigated the unusual mortality of snakeskin gourami at 22 farms in Central Thailand. The moribund fish showed darkened skin, erratic swimming, exophthalmos, and haemorrhaging around the eyeballs, with cumulative mortality between 20% and 45%. Our necropsy findings revealed an enlarged liver and anterior

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19

Misselwitz, B., EB Bachli, P. Kaiser, and JS Goede. "Diagnosis of hypersplenism with the epinephrine stimulation test." Swiss Medical Weekly 143, no. 0102 (2012): w13324. http://dx.doi.org/10.57187/smw.2012.13324.

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PRINCIPLES: Hypersplenism can be defined by thrombocytopenia and/or neutropenia resulting from blood cell sequestration in an enlarged spleen. In multimorbid patients the differential diagnosis of cytopenia is challenging and currently there is no established test for diagnosing hypersplenism. METHODS: The epinephrine stimulation test (EST) measures changes in platelets, neutrophil counts and spleen size following a subcutaneous epinephrine injection. We retrospectively analysed the results of EST in 228 patients. RESULTS: Increases in neutrophils and platelets after epinephrine injection were

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20

Dommerby, H., S. E. Stangerup, M. Stangerup, and S. Hancke. "Hepatosplenomegaly in infectious mononucleosis, assessed by ultrasonic scanning." Journal of Laryngology & Otology 100, no. 5 (1986): 573–80. http://dx.doi.org/10.1017/s0022215100099680.

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SummaryThe present study aims at an assessment of hepato-splenomegaly in infectious mononucleosis (IM). In 29 patients admitted to the ENT department with IM, based on the typical clinical and laboratory findings, including a positive mononucleosis test in most cases, the size of the liver and spleen was estimated by ultrasonic scanning on days 1, 3, 5, 10, 20, 30, 90 and 120 after admission. A control group of eight patients with peritonsillar abscess was included for comparison. The results showed that all patients had an enlarged spleen (mean enlargement: 50–60 per cent) but only a few were

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Theajeal, Rabab F., Bandar M. Al hadeethi, AlZahraa Sh Jasim, and Batool K. Abdullah. "Hepatitis A Profile: Epidemiological, Clinical and Outcomes in Children’s Welfare Teaching Hospital and the Need for Hepatitis A Vaccine Programme Setting." Journal of the Faculty of Medicine Baghdad 67, no. 1 (2025): 10–18. https://doi.org/10.32007/jfacmedbaghdad2410.

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Background: Hepatitis A virus, a single-stranded RNA virus from the family Picornaviridae, is primarily transmitted via the fecal-oral route. The World Health Organization reports about 1.5 million hepatitis A cases annually, with the incidence rates closely linked to socioeconomic conditions. This vaccine-preventable disease is the focus of our research. Objectives: The current research aimed to elucidate the incidence, clinical presentation, and outcomes of hepatitis A in Iraq, highlighting the importance of appropriate preventive measures. Methods: It wasconducted as a retrospective cohort

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Maheshwari, Ujwala, Kalyani Mahore, Evith Pereira та Reeta Dhar. "γδ T-cell lymphoma: a rare entity mimicking hemophagocytic syndrome-report of two cases". International Journal of Research in Medical Sciences 5, № 8 (2017): 3751. http://dx.doi.org/10.18203/2320-6012.ijrms20173601.

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γδ T-cell lymphoma is a rare extranodal and systemic neoplasm which accounts for less than 1% of all NHL having peak incidence in adolescents and young adults with a male predominance. Study report two cases, 29 and 25 years male presented with fever, abdominal pain and pancytopenia; one had hepatosplenomegaly while other had marked splenomegaly respectively and both showing feature of hemophagocytosis. Both underwent splenectomy. On gross examination, the spleen was markedly enlarged and shows a deep brown cut-surface. Histologically the normal structure of the spleen is totally effaced by a

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Shankar, Anjali, Siddharth Gosavi, Tracey Austin Anne, and Anjitha Uthamarajan Nair. "Bernard-Soulier Syndrome with Unusual Presentation of Splenic Infarct." Journal of Evidence Based Medicine and Healthcare 8, no. 07 (2021): 396–98. http://dx.doi.org/10.18410/jebmh/2021/77.

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A 26-year-old male presented to general medicine department on 16th March 2020 with complaints of 3 episodes of epistaxis for 2 days. The epistaxis was spontaneous, sudden in onset, recurring in nature, copious in amount, not relieved on its own. No history of nasal trauma, head injury, fever, joint pain, cough, breathlessness, difficulty in swallowing, pain abdomen, haematuria, rashes. No history of bleeding diathesis from any other site. Past history revealed similar complaints of nasal bleeding for past 2 - 3 months for which he used to get admitted and administered platelets transfusions a

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24

Nikolova, D., A. Yordanov, V. Damyanova, A. Yavorova, and A. Radinov. "Gaucher Disease Type I: A Case Report." Acta Medica Bulgarica 47, no. 3 (2020): 22–25. http://dx.doi.org/10.2478/amb-2020-0029.

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AbstractGaucher disease (GD) is a multi-systemic disease with a low population frequency. It is a lysosomal storage disorder (LSD) that causes accumulation of glucocerebroside in the so called Gaucher cells predominantly in areas like the spleen, liver and bone marrow. Type I GD (GDI) is the most common form and usually does not involve the brain and the spinal cord. The symptoms can range from mild to severe and may appear anytime from childhood to adulthood. Diagnostics can often be challenging and imposes looking at person’s medical history, symptoms, physical exam, and laboratory test resu

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Rao, Suparna Ajit, Tarun K. Dutta, Rakesh V. Naik, Aishwarya Krishnamurthy, and Vinod K. Viswanath. "Disseminated Tuberculosis with Hemophagocytic Lymphohistiocytosis (HLH)." Blood 120, no. 21 (2012): 4686. http://dx.doi.org/10.1182/blood.v120.21.4686.4686.

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Abstract Abstract 4686 A 38 year old woman presented with high grade fever and jaundice for one month. Patient also had reduced appetite and loss of weight for the same period. On examination, patient had significant pallor, icterus and pedal edema. Ultrasonogram showed enlarged liver (20 cms) and enlarged spleen (17.2 cms). Patient was empirically treated for malaria. Her subsequent investigations revealed Hb 35g/dl, total leucocyte count 2×109/l, differential leucocyte count - neutro 82%, lympho 18%, platelet count − 59×109/l, and red cell indices were as follows: MCV 71.6 fL, MCH 21.6 pg/ce

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26

Claster, S., and E. Vichinsky. "First report of reversal of organ dysfunction in sickle cell anemia by the use of hydroxyurea: splenic regeneration." Blood 88, no. 6 (1996): 1951–53. http://dx.doi.org/10.1182/blood.v88.6.1951.bloodjournal8861951.

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Much of the morbidity associated with sickle cell anemia (SCA) is due to ongoing infarction resulting in organ dysfunction. Because the spleen is often the first organ damaged in this illness, there is a significant impairment of the immune system in these patients. Hydroxyurea (HU) has been shown to increase fetal hemoglobin (HbF) and decrease painful episodes in patients with this disease. It is unclear whether HU can prevent organ damage. We treated two SCA patients with HU for several years and found evidence of reversal of previously documented splenic dysfunction. Patient no. 1 was treat

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Pieri, Lisa, Chiara Paoli, Paola Guglielmelli, et al. "A Phase 2 Study Of Ruxolitinib In Patients With Splanchnic Vein Thrombosis Associated With Myeloproliferative Neoplasm. Preliminary Results." Blood 122, no. 21 (2013): 1583. http://dx.doi.org/10.1182/blood.v122.21.1583.1583.

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Abstract Philadelphia-negative Myeloproliferative Neoplasms (MPN) include Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Myelofibrosis, both Primary (PMF) and secondary to PV or ET (PPV-MF and PET-MF). A MPN is frequently the underlying cause of splanchnic vein thrombosis (SVT), accounting for 31.5% of portal vein thrombosis (PVT) and 40.9% of Budd Chiari syndrome (BCS). In patients (pts) with MPN and SVT, splenomegaly can arise as the consequence of the hematological disease and/or blood flow abnormalities consequent to the thrombosis itself. Splenomegaly and the compensatory enla

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Casu, Carla, Paraskevi Rea Oikonomidou, Vania Lo Presti та ін. "Potential Therapeutic Applications of Jak2 Inhibitors and Hif2a-ASO for the Treatment of β-Thalassemia Intermedia and Major". Blood 128, № 22 (2016): 1012. http://dx.doi.org/10.1182/blood.v128.22.1012.1012.

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Abstract β-Thalassemia is one of the most common genetic red blood cell (RBC) disorders characterized by reduced (such as in non-transfusion dependent thalassemia or NTDT) or absent (such as in transfusion dependent thalassemia or TDT) production of β-globin chains. Ineffective erythropoiesis (IE) with consequent anemia leads to extra-medullary hematopoiesis (EMH), splenomegaly and iron overload mediated by low levels of hepcidin. We previously demonstrated that IE in β-thalassemia is associated with increased proliferation and reduced differentiation of erythroid progenitors (Libani et al, 20

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Wynne, Elisabeth, Katie Perkins, Susan Price, Adeline Louie, and V. Koneti Rao. "CT Scan Enumeration of Altered Spleen Status and Pulmonary Artery Size in Patients with Autoimmune Lymphoproliferative Syndrome (ALPS)." Blood 114, no. 22 (2009): 4034. http://dx.doi.org/10.1182/blood.v114.22.4034.4034.

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Abstract Abstract 4034 Poster Board III-970 Background ALPS is a disorder of apoptosis resulting in elevated DNT (CD3+, TCRab+, CD4-, CD8-, B220+ double negative T lymphocyte) cells associated with childhood onset nonmalignant lymphadenopathy, splenomegaly and multilineage cytopenias due to splenic sequestration and autoimmune destruction. Patients with ALPS frequently have altered spleen status: splenomegaly or splenectomy, the latter often-related to refractory chronic AIHA and ITP. This altered spleen status has been associated with pulmonary arterial hypertension (PAH) in two patients with

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Abdullahi, Adama Musa., Iliyasu. Dauda, Muhammed Chafe. Umar, Ibrahim Daneji. Aminu, and Olayinka. Alayande Musibau. "Clinical and histopathological changes of some vital organs associated with intra-peritoneal experimental infection with Trypanosoma evansi in Guinea pigs." International Journal of Life Science and Agriculture Research 04, no. 02 (2025): 146–56. https://doi.org/10.5281/zenodo.14930015.

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The study was designed to evaluate clinico-pathological profiles associated with intra-peritoneal experimental infection with<em> Trypanosoma</em> <em>evansi</em> in Guinea pigs. <em>Trypanosoma</em> <em>evansi</em> or<em> Surra</em> is one of the protozoan diseases that inflict huge economic losses in the livestock industry. The causative<sup> </sup>agent of the disease is <em>Trypanasoma evansi </em>(<em>T. evansi</em>) which affects wide range of domestic and wild animals globally. Twenty guinea pigs (G. pigs) were purchased, screened a

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Husain, Safder, Arish Mohammad Khan Sherwani, Chand Bibi, Mohammed Wasim Ahmed, and Abdul Raheem. "A cross-sectional study to assess the prevalence and contributing factors of anaemia in private school children in Bengaluru." International Journal Of Community Medicine And Public Health 11, no. 8 (2024): 3167–74. http://dx.doi.org/10.18203/2394-6040.ijcmph20242181.

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Background: Anaemia is defined as an Hb concentration below the diagnostic reference range in children. Most school-aged children have anaemia, which is a common clinical disease. The effects of anaemia in school-age children include decreased resistance to disease, greater susceptibility to infection, poorer physical development, and poor academic performance. Consequently, the current study aimed to investigate the prevalence of anaemia among Bengaluru private school students. This involved being aware of the contributing elements or causes of anaemia, as well as teaching schoolchildren abou

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Yunanto, David, and Delita Prihatni. "Female Toddler Presenting with Suspected Gaucher Disease: A Rare Case Report." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 31, no. 3 (2025): 320–24. https://doi.org/10.24293/ijcpml.v31i3.2323.

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Gaucher disease is a rare metabolism disease caused by a mutation of the glucocerebrosidase (GBA1) gene. The mutation causes an accumulation of glucocerebroside lipids (glycolipid glucocerebroside), which are harmful to the body. The accumulation goes within all areas of the body especially within the marrow, liver, and spleen. In the non-Jewish population, Gaucher disease affects 1 out of every 100,000 people. This case report describes the laboratory approach and interpretation of Gaucher disease. A 20-month-old female toddler with an enlarged abdomen accompanied by a history of severe dehyd

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Bianchi, Matheus Viezzer, Gabriela Fredo, Nelson Junior Tagliari, et al. "Autochthonous Canine Visceral Leishmaniasis in Urban Area of Porto Alegre, RS, Brazil." Acta Scientiae Veterinariae 44, no. 1 (2016): 4. http://dx.doi.org/10.22456/1679-9216.84523.

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Background: Leishmaniasis is a chronic infectious disease caused by intracellular protozoan Leishmania that affects canine and human. The visceral leishmaniasis (VL) is caused by the Leishmania donovani complex, in which canines are the main reservoir for human VL. In Southern Brazil, case reports of this disease have increased, especially when canines are infected in endemic areas in the country. Canines usually present a systemic disease, characterized by cutaneous lesions, weight loss, generalized lymphadenopathy, hepatomegaly and splenomegaly. This report aims to describe the clinicalpatho

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Zahid, H., S. Latif, and S. Baby. "POEMS-associated Multicentric Castleman Disease: A diagnostic and Therapeutic Conundrum." American Journal of Clinical Pathology 160, Supplement_1 (2023): S75—S76. http://dx.doi.org/10.1093/ajcp/aqad150.168.

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Abstract Introduction/Objective A rare multisystemic, paraneoplastic hematologic disorder, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) is associated with an overproduction of pro-inflammatory cytokines caused by a plasma cell proliferative disorder. Castleman disease is a rare clinical entity described as a polyclonal lymphoid proliferation, that leads to generalized lymphadenopathy. It is rarely presented in association with POEMS Syndrome. Methods/Case Report A 55-year-old hispanic male, when being evaluated for liver mass, revealed bile duct thicke

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Mistry, Pramod K., Sara Sadan, Ruhua Yang, John Yee, and Mei Yang. "Consequences of Diagnostic Delays in Type 1 Gaucher Disease: A Unique Opportunity among Hematologists/Oncologists for Early Diagnosis and Intervention." Blood 108, no. 11 (2006): 3308. http://dx.doi.org/10.1182/blood.v108.11.3308.3308.

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Abstract Gaucher disease (GD) is a progressive lysosomal storage disease that can lead to life-threatening complications. Anecdotal experiences of patients and physicians suggest that symptoms and signs of the disease may go undiagnosed for many years, resulting in severe yet preventable complications. We conducted surveys of patients and Hematology/Oncology specialists to assess the frequency of diagnostic delays. Furthermore, we reviewed a series of patients in whom prolonged misdiagnosis resulted in serious complications of GD. Of 136 patients surveyed, the average time from first appearanc

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Alam, Md Jahangir, Reaz Mobarak, Md Kamruzzaman, Abu Tayab, Probir Kumar Sarkar, and ABM Mahfuj Hassan Al Mamun. "Clinical Evaluation of Dengue Cases in Bangladesh Shishu Hospital & Institute." Dhaka Shishu (Children) Hospital Journal 39, no. 1 (2024): 9–17. https://doi.org/10.3329/dshj.v39i1.82435.

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Background: In Bangladesh, the re-emergence of dengue patients has created a huge burden on our children’s morbidity and mortality. A dengue outbreak erupted in Bangladesh in 2019, resulting in the highest number of deaths to date. Objective: To see the clinical and laboratory profile and hospital outcome of the children admitted in Bangladesh Shishu Hospital & Institute. Methods: A prospective observational study was conducted among the children having dengue infection at the inpatient department of Bangladesh Shishu Hospital & Institute from 1st August 2022 to 31st January 2023. A to

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Postanogova, Nina Olegovna, Lyudmila Vasil’evna Sofronova, and Ferdausa Ravkhatovna Milyakova. "Clinical and laboratory features of infectious mononucleosis depending on the etiological factor in children." Pediatrician (St. Petersburg) 6, no. 4 (2015): 19–22. http://dx.doi.org/10.17816/ped6419-22.

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The article contains the results of observations in 54 children aged 1 to 6 years with infectious mononucleosis. The evaluated of clinical and laboratory data with consideration of the etiological factor of the disease. Depending on the etiology there are 3 groups of patients: 18 with EBV-associated IM, 18 with CMV IM and 18 with mixed etiology mononucleosis (EBV + CMV). All children received antibiotic therapy (cephalosporin of third generation), immunostimulatory drugs, in a dosage of age (recombinant interferon Alfa-2b) and symptomatic treatment. Verification of pathogens was carried out by

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Mahjabun, Shafaat, Humayun Kabir, Meftah Islam, et al. "Clinical investigation of different types of cases of outdoor patients using ultrasonography in Rangpur Medical College Hospital, Bangladesh." Asian Journal of Medical and Biological Research 6, no. 2 (2020): 294–98. http://dx.doi.org/10.3329/ajmbr.v6i2.48074.

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Ultrasonography is an easy, noninvasive, rapid investigation advised by doctors worldwide. Hence we diagnosed different types of cases through ultrasonography at outdoor patients admitted to Department of Rangpur Medical College Hospital, Rangpur Bangladesh over a period of four months. Our objective was to investigate the prevalence of different types of cases diagnosed and evaluated by ultrasonography in a variety of physical conditions with multiple clinical scenarios. Ultrasonography were performed using GE Logiq V5 Expert ultrasound machine with linear and curved linear phased array trans

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Huang, Qin, Haihong Zhang, Lawrence M. Weiss, and Chun-Yang Fan. "Mitochondria Damage Leading to High Frequency of Lymphoma and Myeloproliferative Disorder in Transgenic Mice Overexpressing a Human 8-Oxoguanine DNA-Glycosylase Gene." Blood 108, no. 11 (2006): 2246. http://dx.doi.org/10.1182/blood.v108.11.2246.2246.

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Abstract Alterations of nuclear genes in human lymphoma and leukemias have been well investigated in past several decades and established a predominant role in the pathogenesis. However, the relationship of mitochondrial genome alteration or dysfunction and human lymphoma and leukemias remains large unknown. Mitochondria are dynamic organelles that play critical roles in oxidative phosphorylation, energy metabolism, cell growth and apoptosis. We have successfully generated a novel transgenic (TG) mouse model of mitochondrial disorder by overexpressing human hOGG1, a base excision DNA repair ge

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Yang, Yang, Sorab Gupta, Rashmika Potdar, Mark S. Morginstin, and Gabor Varadi. "Cases of Extra- Medullary Myeloma Presenting As Liver Infiltrates: A Single Community Hospital Experience." Blood 132, Supplement 1 (2018): 5644. http://dx.doi.org/10.1182/blood-2018-99-117720.

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Abstract Introduction: Multiple Myeloma (MM) accounts for 13% of all hematologic malignancies. Plasma cells (PC) proliferation is mainly restricted to the bone marrow (BM) in most of the patients. Extramedullary myeloma (EMM) is defined by the PCs outside the bone marrow. The prevalence of EMM in myeloma patients has been reported at 7 to 15 percent in newly diagnosed patients and from 6 to 20 percent in relapsed setting. Patients with EMM have poor prognosis with a median overall survival of < 6 months. This abstract presents two cases of MM with initial presentation as a liver infiltrate.

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Matsuoka, Sahoko, Atsushi Hirao, Fumio Arai, et al. "Rb Plays an Essential Role in Erythroid Differentiation through Inhibition of Apoptosis Mediated by NFKB." Blood 106, no. 11 (2005): 308. http://dx.doi.org/10.1182/blood.v106.11.308.308.

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Abstract Inactivation of the retinoblastoma (Rb) gene results in embryonic lethality due to severe anemia and increased nucleated erythrocytes by day14. However, molecular mechanisms of the function of Rb in erythroid differentiation have been unclear. Recent studies have suggested that Rb has both intrinsic and extrinsic roles on erythroid differentiation. Using Rb-deficient (Rb−/−) embryos(E12), we showed that Rb regulates terminal erythroid differentiation through inhibition of apoptosis mediated by NFKB. Enucleation of erythroblasts was impaired in semisolid culture of Rb−/− hematopoietic

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Muto, Hideharu, Mamiko Sakata-Yanagimoto, Yasuyuki Miyake, et al. "Reduced Tet2 Function Contributes to Development of Peripheral T-Cell Lymphoma with Follicular Helper T-Cell-Like Features in Mice." Blood 120, no. 21 (2012): 1299. http://dx.doi.org/10.1182/blood.v120.21.1299.1299.

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Abstract Abstract 1299 Background: Loss-of-function mutations in TET2 are frequent in human myeloid and lymphoid malignancies. Especially, TET2 mutations were found in 30–47% of angioimmunoblastic T-cell lymphoma (AITL) and 10–38% of peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS). The tumor origin of AITL is thought to be follicular helper T cells (Tfh). PTCL, NOS is a group of heterogenous T-cell-derived lymphomas, whereas some cases of PTCL, NOS also appear to be derived from Tfh. Several recent papers reported that Tet2 knockout mice demonstrated premalignant status of myel

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Ahmad, Sara Miriam, and Bryan Jiang. "The Grave Hematologic and Hepatic Effects of Hyperthyroidism." Journal of the Endocrine Society 5, Supplement_1 (2021): A959. http://dx.doi.org/10.1210/jendso/bvab048.1960.

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Abstract Background: Hyperthyroidism can present with a myriad of symptoms including some rare, but morbid systemic manifestations. Here we present the case of a patient who presented with thyrotoxicosis, pancytopenia and cholestatic liver disease. Clinical Case: A 37 year-old Hispanic female with no significant past medical history presented with weight loss, fatigue, jaundice and irregular menstrual cycles ongoing for 10 months. Upon presentation, vitals were notable for mild tachycardia. She had significant jaundice and a visibly enlarged thyroid gland, while no thyroid eye disease was note

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Yin, Bin, Jennifer L. Jeske-Geurts, Miechaleen D. Diers, Kevin M. Shannon, and David A. Largaespada. "Bcl11a Causes Leukemia/Lymphoma in Cooperation with Nf1 Inactivation." Blood 108, no. 11 (2006): 387. http://dx.doi.org/10.1182/blood.v108.11.387.387.

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Abstract Loss of the NF1 (Neurofibromatosis Type 1) tumor suppressor gene is associated with chronic and acute forms of myeloid diseases including juvenile myelomonocytic leukemia (JMML). In the BXH-2 strain of mice, acute myeloid leukemia (AML) is caused by chronic infection by a murine leukemia virus (MuLV). We have reported the identification of 37 common proviral insertion sites (CIS), loci containing candidate genes whose mutation could cooperate with inactivation of Nf1 to result in BXH-2 AML. Among these candidate genes, Bcl11a, was shown to be expressed in JMML and CMML leukemia sample

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Huang, Qin, Haihong Zhang, Yubo Ma, et al. "Development of Essential Thrombocythemia-Like Myeloproliferative Disorder in Transgenic Mice Overexpressing a Human 8-Oxoguanine DNA-Glycosylase Gene." Blood 104, no. 11 (2004): 791. http://dx.doi.org/10.1182/blood.v104.11.791.791.

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Abstract Essential thrombocythemia (ET) is a clonal myeloproliferative disease that involves primarily the megakaryocytic lineage. ET is characterized by sustained thrombocytosis in the blood and increased in numbers of large, mature megakaryocytes in the marrow and, occasionally, in the extramedullary organs. Currently, there is no known genetic or biologic marker specific for ET. The etiology and pathogenesis of ET remain largely unclear, partially due to a lack of suitable animal model for the disease. We reported here the development of a transgenic (TG) mouse model, in which most aged mic

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Tsang, L., J. Abraldes, E. Wiebe, G. S. Sandha, and S. van Zanten. "A226 INCIDENTAL FINDING OF A LARGE GASTRIC VARIX ASSOCIATED WITH NEONATAL UMBILICAL VEIN CANALIZATION." Journal of the Canadian Association of Gastroenterology 4, Supplement_1 (2021): 261–63. http://dx.doi.org/10.1093/jcag/gwab002.224.

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Abstract Results A 41-year old Asian male, who immigrated to Canada many years ago, and who had previously been successfully treated for Helicobacter pylori infection underwent gastroscopy for investigation of dyspepsia. His gastroscopy was normal except for a large subepithelial abnormality that was noted close to the gastroesophageal junction. Routine gastric biopsies from the antrum and body were normal. Subsequent endoscopic ultrasound revealed flow through the anechoic tortuous lesion and confirmed it was a very large isolated gastric varix type 1. Abdominal CT scan revealed chronic occlu

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Vargas, Pablo, Roberto Ovilla, Martha Alvarado, et al. "Compassionate Use Program (CUP) with Ruxolitinib in Mexican Patients with Primary Myelofibrosis (PMF), Post – Polycythemia, Vera Myelofibrosis (PPV – MF), and Post–Essential Thrombocythemia Myelofibrosis (PET – MF)." Blood 120, no. 21 (2012): 5067. http://dx.doi.org/10.1182/blood.v120.21.5067.5067.

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Abstract Abstract 5067 Introduction Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) that is characterized by ineffective hematopoiesis and symptomatic burden such as cytopenias, and splenomegaly. The prevalence of MF symptoms is relatively uniform across the 3 main subtypes: primary MF (PMF), post – polycythemia vera MF (PPV MF), and post – essential thrombocythemia MF (PET MF). Available therapies (AT) in Mexico, includes hydroxyurea (HU), interferon (IFN), for ET, besides phlebotomy for PV, as well as androgens, steroids, chemotherapy, IFN, thalidomide, EPO and radiotherapy for PMF

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Matsuoka, Sahoko, Atsushi Hirao, Fumio Arai, et al. "Rb Regulates Erythroid Differentiation through Bcl-XL-Dependent Anti-Apoptotic Effect." Blood 104, no. 11 (2004): 1261. http://dx.doi.org/10.1182/blood.v104.11.1261.1261.

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Abstract Inactivation of the retinoblastoma (Rb) gene results in embryonic lethality due to severe anemia and increased nucleated erythrocytes by day E14.5. However, molecular mechanisms of the function of Rb in erythroid differentiation have been unclear. Recent studies have suggested that Rb has both intrinsic and extrinsic roles on erythroid differentiation. Here we showed that Rb regulates terminal erythroid differentiation through inhibition of apoptosis. Enucleation of erythroblasts was impaired in semisolid culture of Rb−/− hematopoietic progenitors in fetal liver. The lethally-irradiat

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Ahmed, Mashrafi, Fawwad Zaidi, Tahmina Begum, and Ashok R. Patel. "Correlation Between Spleen Size, Thrombocytopenia and Meld Score in Chronic Liver Disease and Their Relation with Hospital Readmission." Blood 126, no. 23 (2015): 5567. http://dx.doi.org/10.1182/blood.v126.23.5567.5567.

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Abstract Introduction: Cirrhosis of liver due to chronic hepatitis B and/or C is a significant health care burden globally. Thrombocytopenia is one of the significant co-morbid conditions associated with cirrhosis. Splenomegaly had been pointed as one of the main factors behind thrombocytopenia in multiple studies. Another important aspect of this clinical condition is its high economic impact in the national health care budget. In this study, we re-evaluated the relation between thrombocytopenia, MELD score and spleen size in liver cirrhosis associated with chronic hepatitis B and/or C. We al

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Zhang, Shouyuan, Yanyan Zhu, Yanyan Jin, Hong Sun, Weiqun Wang, and Lu Zhan. "Difference between Acyclovir and Ganciclovir in the Treatment of Children with Epstein–Barr Virus-Associated Infectious Mononucleosis." Evidence-Based Complementary and Alternative Medicine 2021 (October 20, 2021): 1–6. http://dx.doi.org/10.1155/2021/8996934.

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Objective. To investigate the efficacy differences between acyclovir and ganciclovir in the treatment of children with Epstein–Barr virus (EBV)- associated infectious mononucleosis (IM). Methods. A total of 128 children with EBV-IM who were admitted to our hospital from February 2019 to February 2021 were selected and randomly divided into the acyclovir group (n = 64) and the ganciclovir group (n = 64) according to the random number table method. All the children were given symptomatic treatments such as protecting the liver and reducing fever. On this basis, the acyclovir group was given an i

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