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Relevant bibliographies by topics / Spontaneous Bleeding

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Academic literature on the topic 'Spontaneous Bleeding'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Spontaneous Bleeding"

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Henriksson, Anders E., and David Bergqvist. "Spontaneous Pancreatic Bleeding." World Journal of Surgery 27, no. 2 (2003): 187–89. http://dx.doi.org/10.1007/s00268-002-6352-2.

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Moon, J. M., S. C. Lee, and B. J. Chun. "Spontaneous intercostal artery bleeding." Emergency Medicine Journal 25, no. 1 (2008): 53–54. http://dx.doi.org/10.1136/emj.2007.052548.

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Broughan, Thomas A., and Eric M. Walser. "Spontaneous Hepatic Hemorrhage in Older Women." American Surgeon 73, no. 11 (2007): 1147–50. http://dx.doi.org/10.1177/000313480707301115.

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Spontaneous liver hemorrhage in older women is not well described. We report an experience with five postmenopausal women who spontaneously bled from the liver. All five patients presented with acute bleeding. Four were treated nonoperatively. No tumor was identified in any patient. Four patients acutely were discharged alive and well, but one died after operation to control bleeding. Spontaneous liver hemorrhage can occur in a variety of clinical settings, but an association with older women taking hormone replacement and anticoagulation has not been reported.

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Ho-Tin-Noé, B., and S. Jadoui. "Spontaneous bleeding in thrombocytopenia: Is it really spontaneous?" Transfusion Clinique et Biologique 25, no. 3 (2018): 210–16. http://dx.doi.org/10.1016/j.tracli.2018.06.005.

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Meyer, F., C. Wybranski, C. J. Bruns, O. Jannasch, V. Aumann, and C. Chiapponi. "Spontaneous omental bleeding in a 20-year old patient with hemophilia A." Hämostaseologie 36, S 02 (2016): S22—S24. http://dx.doi.org/10.5482/hamo-15-01-0003.

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SummarySpontaneous intraabdominal hemorrhage is a very rare event even in patients with bleeding disorders like hemophilia. Nevertheless this rare case must be considered in patients with coagulopathies presenting with abdominal pain. Prompt radiologic imaging and surgical consultation are of highest priority. Here we report on a 20-year-old patient with moderate hemophilia A, who underwent emergency laparotomy for a spontaneous idiopathic bleeding of the omentum majus. There are few cases in the literature on this sort of event in patients with hemophilia, who mostly suffer from spontaneous j

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Yen, Chu Yu, and Chun-Chen Chen. "Spontaneous bleeding from orbital haemangioma in drug-induced thrombocytopaenia." BMJ Case Reports 14, no. 7 (2021): e241741. http://dx.doi.org/10.1136/bcr-2021-241741.

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An 81-year-old woman, a drug-induced thrombocytopaenia (DITP) patient, presented with a case of spontaneous bleeding from an orbital haemangioma manifesting as a sudden onset of ocular pain, proptosis and limited eye movement. Image studies revealed an extraconal, cystic lesion with haemorrhage. The ophthalmopathy was caused by the bleeding of the orbital haemangioma and it was resolved after embolisation of the feeding vessels. Spontaneous bleeding of orbital haemangioma is rare. This case emphasises that DITP may be the cause of spontaneous bleeding of orbital haemangioma by precipitating th

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Akyüz, Osman, Müslüm Ergün, Naile Dölek, and Kamil Çam. "Spontaneous severe retroperitoneal hemorrhage with concomitant renal pelvis rupture during the course of COVID-19 infection: a case report." Yeni Üroloji Dergisi 17, no. 2 (2022): 98–103. http://dx.doi.org/10.33719/yud.2022;17-2-1026408.

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Spontaneous rupture of the renal pelvis is a rarely encountered urological event that causes extravasation of urine. It often occurs as a result of increased intrapelvic pressure secondary to obstructions developed in the urinary system. Similarly spontaneous retroperitoneal hematoma is retroperitoneal hemorrhage that occurs without trauma or an underlying pathology. In this study, we present a case of spontaneous rupture of the renal pelvis that developed secondary to compression of the hematoma that occurred spontaneously in the retroperitoneum in a 63-year-old female patient who received an

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Solomon, D. J. "Spontaneous subcapsular renal haematoma." South African Journal of Radiology 4, no. 2 (2000): 18–20. http://dx.doi.org/10.4102/sajr.v4i2.1528.

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Spontaneous subcapsular renal haematoma is a rare condition caused by bleeding into the subcapsular or perinephric space in the absence of trauma, bleeding diathesis or anticoagulation. If the contralateral kidney is normal, radical nephrectomy is recommended due to a high incidence of small occult tumours.

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Talapatra, Avraneel, Michael J. Nash, Charles R. M. Hay, and Jecko Thachil. "Acquired haemophilia: an easy diagnosis to miss in a patient taking warfarin." Acute Medicine Journal 14, no. 3 (2015): 122–24. http://dx.doi.org/10.52964/amja.0447.

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Acquired Haemophilia (AH) is an autoimmune bleeding disorder, which despite being rare, can be fatal. It occurs in patients with previously normal haemostasis who spontaneously develop IgG autoantibodies against factor VIII. Unlike congenital haemophilia, it manifests as spontaneous bleeding into skin and soft tissues. The presentation can be masked in patients who are receiving warfarin where the bleeding is often attributed to warfarin therapy, as in the case described in this report. Consideration of AH is important in patients taking anticoagulants, when coagulopathy and bleeding fails to

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Kuwayama, Naoya, Shinichiro Takahashi, Makoto Sonobe, and Kyoichi Sugita. "Spontaneous bilateral extradural hematomas." Journal of Neurosurgery 62, no. 1 (1985): 139–41. http://dx.doi.org/10.3171/jns.1985.62.1.0139.

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✓ Spontaneous extradural hematomas are rare and may be caused by pericranial infections, bleeding tendencies, or vascular abnormalities of the dura mater. The authors describe a case of spontaneous bilateral extradural hematomas assumed to be caused by a bleeding tendency with hypofibrinogenemia. A brief review of the literature is reported.

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Dissertations / Theses on the topic "Spontaneous Bleeding"

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Haus, Sebastian. "Anisokorie im Schockraum – Prognosefaktoren für das klinische Outcome." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3E04-7.

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Books on the topic "Spontaneous Bleeding"

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Provan, Drew, Trevor Baglin, Inderjeet Dokal, and Johannes de Vos. Haemostasis and thrombosis. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0010.

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Assessing haemostasis - The coagulation system - Laboratory tests - Platelets - Bleeding - Bleeding: laboratory investigations - Bleeding: therapeutic products - von Willebrand disease - Haemophilia A and B - Rare congenital coagulation disorders - Congenital thrombocytopenias - Congenital platelet function defects - Congenital vascular disorders - Haemorrhagic disease of the newborn - Thrombocytopenia (acquired) - Specific thrombocytopenic syndromes - Disseminated intravascular coagulation - Liver disease - Renal disease - Acquired anticoagulants and inhibitors - Treatment of spontaneous FVII

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Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos, and Angela Theodoulou. Haemostasis and thrombosis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199683307.003.0010_update_001.

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Assessing haemostasis - The coagulation system - Laboratory tests - Platelets - Bleeding - Bleeding: laboratory investigations - Bleeding: therapeutic products - von Willebrand disease - Haemophilia A and B - Rare congenital coagulation disorders - Congenital thrombocytopenias - Congenital platelet function defects - Congenital vascular disorders - Haemorrhagic disease of the newborn - Thrombocytopenia (acquired) - Specific thrombocytopenic syndromes - Disseminated intravascular coagulation - Liver disease - Renal disease - Acquired anticoagulants and inhibitors - Treatment of spontaneous FVII

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Matthew Kynes, J. Hemophilia (Presentation in Emergency Surgery). Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0085.

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Hemophilia is a complex disease of variable severity that affects clotting function and has significant implications in perioperative and emergency care. Hereditary or de novo mutations cause deficiencies in factor VIII or IX production, which may manifest as spontaneous bleeding into joint spaces, muscles, or other sites in severe forms of the disease. Intracranial bleeding is one of the most serious and often fatal complications. In a patient with abnormal bleeding, laboratory results indicative of hemophilia include an increased partial prothromboplastin time (PT), with normal prothrombin t

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Wilson, John W., and Lynn L. Estes. Intra-Abdominal Infections. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0116.

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• Peritoneal infection without an obvious source• Adult patients with cirrhosis and ascites (higher risk: gastrointestinal [GI] bleeding, previous spontaneous bacterial peritonitis [SBP], or low protein concentration in ascitic fluid) or, occasionally, congestive heart failure, malignancy, or connective tissue disease• Pediatric patients with postnecrotic cirrhosis, nephrotic syndrome, or urinary tract infections...

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Sharma, Deepak, and Julia Metzner. Nontraumatic Intracranial Hemorrhage. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0062.

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Nontraumatic subarachnoid, intraventricular, or intraparenchymal hemorrhage can be caused by either rupture of an aneurysm or arteriovenous malformation or by coagulopathy, hypertension, or vasculitis. Pituitary apoplexy results from spontaneous hemorrhage or infarction into a pituitary tumor. Additionally, anesthesiologists must be prepared to manage intraoperative bleeding during craniotomies. Successful management of nontraumatic intracranial hemorrhage requires (1) careful preoperative evaluation and preparation considering extracranial manifestations of intracranial bleeding; (2) administ

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Keshav, Satish, and Alexandra Kent. Rectal bleeding. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0030.

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Rectal bleeding is a common symptom, affecting all age groups, with the highest incidence in the sixth and seventh decades and associated with a higher mortality and morbidity with increasing age. Epidemiological studies have shown rectal bleeding to occur in nearly 1% of hospital admissions. Bleeding stops spontaneously in 80% of cases, although rebleeding occurs in 25%. Common causes are haemorrhoids, diverticular disease, and colorectal cancer or polyps.

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Hemophilia. Exon Publications, 2021. http://dx.doi.org/10.36255/hemophilia.

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Hemophilia is a rare genetic disorder that affects the blood’s ability to clot, leading to prolonged or spontaneous bleeding. This article provides a comprehensive guide to understanding hemophilia, covering its causes, symptoms, and treatment options. It begins with an introduction to what hemophilia is and explains its impact on the body. The article describes the types of hemophilia, focusing on Hemophilia A and Hemophilia B, and their genetic basis involving mutations in the F8 and F9 genes. It explores how the condition is inherited, emphasizing its X-linked pattern, which primarily affec

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Finn, Patrick C., and Michael C. Reade. Bleeding Emergencies (DRAFT). Edited by Raghavan Murugan and Joseph M. Darby. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190612474.003.0010.

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This chapter is concerned with coagulopathic and non-coagulopathic bleeding in the perioperative period, after trauma, and spontaneously, as a result of hematologic and other disease. The initial assessment and management of all potentially bleeding patients is to stop any obvious bleeding through mechanical first aid measures, then address airway or breathing compromise, and obtain intravenous (or intraosseous) access. Obvious external hemorrhage is easily identified, but most patients with bleeding emergencies who are already hospitalized will have occult blood loss. Physical examination sho

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Kobayashi, Leslie M., and Raul Coimbra. Diagnosis and management of lower gastrointestinal haemorrhage in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0180.

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Lower gastrointestinal bleeding (LGIB) is a common cause of anaemia, and can be a significant cause of bleeding and hypovolaemic shock. Initial treatment should always begin with protection of the airway, fluid resuscitation, and restoration of haemodynamic stability. Early colonoscopy should be utilized for all patients with brisk bleeding and elective colonoscopy for those who are stable. An alternative to endoscopy is angiography. Surgery is reserved for patients recalcitrant to endoscopy and/or angiography, or those with poor response to resuscitation. Patients with very slow haemorrhage o

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Leys, Didier, Charlotte Cordonnier, and Valeria Caso. Stroke. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0067.

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Stroke is a major public health issue. Many are treatable in the acute stage, provided patients are admitted soon enough. The overall incidence of stroke in Western countries is approximately 2400 per year per million inhabitants, and 80% are due to cerebral ischaemia. The prevalence is approximately 12 000 per million inhabitants. Stroke is associated with increased long-term mortality, handicap, cognitive and behavioural impairments, recurrence, and an increased risk of other types of vascular events. It is of major interest to take the heterogeneity of stroke into account, because of differ

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Book chapters on the topic "Spontaneous Bleeding"

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Layne, Kerry. "Spontaneous Bleeding." In 100 Diagnostic Dilemmas in Clinical Medicine, 2nd ed. CRC Press, 2023. http://dx.doi.org/10.1201/9781003344117-13.

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Castaman, Giancarlo, Marco Ruggeri, Eros Di Bona, and Francesco Rodeghiero. "Management of Spontaneous Bleeding and Prevention of Bleeding After Dental Extractions and Other Surgical Procedures in Mild Hemophilia a and Von Willebrand’s Disease: Ten Years of Experience at the Vicenza Hemophilia and Thrombosis Center." In Desmopressin in Bleeding Disorders. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2922-4_29.

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Pruthi, Rajiv K. "Bleeding Disorders." In Mayo Clinic Internal Medicine Board Review, 12th ed., edited by Christopher M. Wittich, Thomas J. Beckman, Sara L. Bonnes, et al. Oxford University PressNew York, 2019. http://dx.doi.org/10.1093/med/9780190938369.003.0040.

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Abstract Bleeding disorders consist of clotting factor deficiencies or inhibitors, vascular bleeding disorders, and platelet disorders (quantitative and qualitative). Each of these is broadly classified into congenital disorders and acquired disorders. The best screening tool to evaluate for a bleeding disorder is a thorough clinical evaluation (personal and family bleeding history and physical examination). The presence of a bleeding disorder may be suggested from inquiry into the presence and age at onset of spontaneous bleeding (eg, epistaxis, easy bruising, or joint bleeding), unusual or u

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Wyatt, Jonathan P., Robin N. Illingworth, Colin A. Graham, Kerstin Hogg, Michael J. Clancy, and Colin E. Robertson. "Obstetrics and gynaecology." In Oxford Handbook of Emergency Medicine. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199589562.003.0013.

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Gynaecological problems 564 Vaginal discharge 566 Contraceptive problems 568 Genital injury and assault 570 Gynaecological pain 572 Vaginal bleeding 574 The pregnant patient 576 Emergency normal delivery 578 Difficulties in normal delivery 580 Vaginal bleeding in pregnancy 582 Spontaneous abortion 584 Ectopic pregnancy 586 Vaginal bleeding in later pregnancy ...

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Backlund, Brandon H. "Spontaneous abortion, ectopic pregnancy, and vaginal bleeding." In Emergency Medicine Secrets. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-323-07167-3.00087-5.

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Baglin, Trevor. "Evaluation of the patient with a bleeding tendency." In Oxford Textbook of Medicine. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.220602.

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An apparent bleeding tendency is a common clinical problem, with presentation varying from acute unexpected bleeding during or immediately after surgery, to spontaneous unusual or excessive bruising, purpura, epistaxis, or a chronic haemorrhagic tendency. The following are important aspects of the assessment of the patient....

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"Drugs for Spontaneous Heavy, Irregular or Infrequent Menstrual Bleeding." In Gynecological Drug Therapy. CRC Press, 2016. http://dx.doi.org/10.3109/9781420016345-8.

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"Hemophilia: Public Education." In Hemophilia. Exon Publications, 2021. http://dx.doi.org/10.36255/hemophilia-public-education.

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Hemophilia is a rare bleeding disorder caused by a deficiency in specific clotting factors in the blood, leading to prolonged or spontaneous bleeding. This comprehensive article explores the causes, symptoms, and genetic basis of hemophilia, detailing the various types, including Hemophilia A and B, and the associated genes, such as F8 and F9. It explains how the condition is diagnosed, treated, and managed, emphasizing the role of replacement therapies and newer drugs like emicizumab (Hemlibra). Designed for patients, families, and caregivers, this article aims to provide clear, complete, and

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Baglin, Trevor. "Evaluation of the patient with a bleeding tendency." In Oxford Textbook of Medicine, edited by Chris Hatton and Deborah Hay. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0544.

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An apparent bleeding tendency is a common clinical problem, with presentation varying from acute unexpected bleeding during or immediately after surgery or dental extraction, to spontaneous unusual or excessive bruising, purpura, epistaxis, or a chronic haemorrhagic tendency. Long-standing bleeding symptoms suggest a lifelong condition, whereas recent-onset bleeding suggests an acquired disorder. If a bleeding disorder has been diagnosed and characterized in another family member, then the cause of bleeding may be easily identified, but the absence of a family history does not exclude a herita

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Singh, Ms Shikha. "Haematological Disease-III." In Edited Book of Pathophysiology. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurebch9.

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Hematological diseases encompass various disorders affecting blood cells and coagulation, with hereditary acquired anemia and hemophilia being notable examples. Hereditary acquired anemia refers to anemia resulting from inherited genetic mutations that impair red blood cell production, structure, or function. These conditions include hereditary spherocytosis, G6PD deficiency, and hereditary elliptocytosis. The pathophysiology involves defects in the red blood cell membrane or enzymes, leading to hemolysis. Epidemiologically, these conditions vary in prevalence based on ethnicity and geographic

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Conference papers on the topic "Spontaneous Bleeding"

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Kassamali, Rahil, Adam Mushtak, Sohaib Bassam Zoghoul, et al. "Understanding the Management of Acute Spontaneous Bleeding in Patients with COVID-19." In PAIRS 2023 Annual Congress. Thieme Medical and Scientific Publishers Pvt. Ltd., 2023. http://dx.doi.org/10.1055/s-0043-1763354.

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Adam, Kristine, Leo Rossler, Christine Decker, et al. "P 736. Benign Enlargement of Subarachnideal Spaces and Subdural Hematoma in an Infant: Spontaneous Bleeding, Child Abuse, or Bleeding Disorder?" In Abstracts of the 44th Annual Meeting of the Society for Neuropediatrics. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1675972.

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Örmeci, Ahmet Rifat, Tugba GURSOY KOCA, Selim DERECI, and Mustafa AKCAM. "P227 Solitary juvenile polyp manifesting as spontaneous resection with rectal bleeding in a child." In 8th Europaediatrics Congress jointly held with, The 13th National Congress of Romanian Pediatrics Society, 7–10 June 2017, Palace of Parliament, Romania, Paediatrics building bridges across Europe. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313273.315.

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Rodrigues, Amanda Gabriele Coelho, Ana Cassia Gonzalez dos Santos Estrela, Ligia Aurelio Vieira Pianta Tavares, and Beatriz Trajano Costa da Silva. "Hypopituitarism versus spontaneous subarachnoid hemorrhage." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.379.

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Introduction: Spontaneous subarachnoid hemorrhage (SAH) is a medical emergency characterized by bleeding in the subarachnoid space, of nontraumatic etiology. Studies demonstrate the relationship of HSA in the pathogenesis of hypopituitarism, which are important due to the need to develop new therapeutic and diagnostic tools. Objectives: To highlight hormonal complications after SAH. Methods: A literature review was carried out in the Scielo and PubMed databases, using the descriptors: “aneurysmal subarachnoid haemorrhage” “hormone deficiency” and “hypopituitarism”, limited to articles in Engli

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AlJohani, Abdullah, Mustafa Owaidah, Faisal Joueidi, et al. "The Outcome of Conservative and Endovascular Embolization of Spontaneous Intra-abdominal Bleeding Related to Anticoagulants/Antiplatelets." In PAIRS 2024 Annual Congress. Thieme Medical and Scientific Publishers Pvt. Ltd., 2024. http://dx.doi.org/10.1055/s-0044-1785923.

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Danesh, B. J. Z., A. R. Saniabadi, R. I. Russell, G. D. O. Lowe, and C. D. Forbes. "COMPARISON OF THE EFFECT OF ASPIRIN (ASA) AND CHOLINE MAGNESIUM TRISALICYLATE (CMT) ON PLATELET AGGREGATION IN WHOLE BLOOD EX-VIVO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644866.

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Suppression of platelet aggregation by ASA limits the therapeutic use of this drug as an analgesic in patients with bleeding tendencies. CMT is a non-acetylated salicylate derivative with analgesic and anti-inflammatory effect similar to that of ASA. We compared platelet aggregation in human whole blood ex-vivo, three hours after ingestion of ASA and. CMT. Using a whole blood platelet counter, platelet aggregation was quantified by measuring the fall in the number of single platelets at peak aggregation in response to collagen (lμg/ml) arachidonic acid (AA, 0.5 mM) as well as spontaneous aggre

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Janzarik, H., D. Heinrich, and R. H. BÖdeker. "COMPARISON OF A MODIFIED BLEEDING TIME/ “HAEMOSTASIS TIME” (HT), WITH THE DUKE AND IVY/TEMPLATE BLEEDING TIMES IN HAEMOPHILIA AND VON WILLEBRAND’S DISEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644222.

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The occlusion time of a Butterfly 25 short cannula inserted into the cubital vein was assessed as a new bleeding time modification. The method excludes the influences of vessel wall and tissue factors since primary haemostasis takes place on the standard surface of the cannula. Avoiding scar formation, the technique can be repeated deliberately. It could be shown that HT correlated better than the Duke and Ivy/ template bleeding times with reduced platelet counts and reflected the effects of aspirin and unfractionated heparin in the same way (Janzarik et al., Blut 1986, 52:345).HT was applied

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JakloyazAy, A. M., and Oa H. dnagy. "CONGENITAL AFIBRINOGENAEMIA: DIAGNOSIS, CLINICAL FEATURES, FOLLOW-UP STUDY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644856.

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Authors followed 6 cases of congenital afibrinogenae- mia (CA) by offsprings of two apparently unrelated families from the same village. The sex ratio was4.m/3.f. CA is a rare autosomal recessive disease. Controlling 76 family members authors detected 11 cases of moderate and 2 cases of severe hypofibrinogeneemia.Among them-without any bleeding tendency-the mother of one case and both parents of two siblings with CA*The lack of fibrinogen was confirmed biochemically and immunologically too. The only symptom ofthe Illness are the severe posttraumatic bleeding. They appear as epistax- is, bleedi

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Castro, Millette. "IDDF2018-ABS-0249 Spontaneous cholecystocolonic fistula in an elderly male: a rare cause of massive lower gi bleeding." In International Digestive Disease Forum (IDDF) 2018, Hong Kong, 9–10 June 2018. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-iddfabstracts.42.

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Gordge, M. P., R. W. Faint, P. B. Rylance, and G. H. Neild. "THE BLEEDING TENDENCY OF PROGRESSIVE RENAL FAILURE IS NOT ASSOCIATED WITH DEFECTIVE PLATELET AGGREGATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644566.

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The bleeding tendency of uraemia may be related to reduction by anaemia of erythrocyte/platelet interaction, toxic inhibition of platelet aggregation and abnormal von Willebrand Factor (vWF) mediated platelet adhesion. Our aim in this study was to determine at what stage of renal failure bleeding time becomes prolonged and to investigate the mechanisms involved.We have measured bleeding time (Simplate II), plasma levels of fibrinogen and vWF, and ex-vivo platelet responsiveness in 31 patients with chronic renal failure (CRF) of various degrees of severity and compared them with values obtained

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