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Journal articles on the topic 'Stem progenitor cell'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Carpino, Guido, Anastasia Renzi, Antonio Franchitto, et al. "Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration." Stem Cells International 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/3658013.

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Niches containing stem/progenitor cells are present in different anatomical locations along the human biliary tree and within liver acini. The most primitive stem/progenitors, biliary tree stem/progenitor cells (BTSCs), reside within peribiliary glands located throughout large extrahepatic and intrahepatic bile ducts. BTSCs are multipotent and can differentiate towards hepatic and pancreatic cell fates. These niches’ matrix chemistry and other characteristics are undefined. Canals of Hering (bile ductules) are found periportally and contain hepatic stem/progenitor cells (HpSCs), participating

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2

Hu, Wen-Yang, Dan-Ping Hu, Lishi Xie, et al. "Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells." International Journal of Molecular Sciences 22, no. 15 (2021): 8109. http://dx.doi.org/10.3390/ijms22158109.

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Single prostate stem cells can generate stem and progenitor cells to form prostaspheres in 3D culture. Using a prostasphere-based label retention assay, we recently identified keratin 13 (KRT13)-enriched prostate stem cells at single-cell resolution, distinguishing them from daughter progenitors. Herein, we characterized the epithelial cell lineage hierarchy in prostaspheres using single-cell RNA-seq analysis. Keratin profiling revealed three clusters of label-retaining prostate stem cells; cluster I represents quiescent stem cells (PSCA, CD36, SPINK1, and KRT13/23/80/78/4 enriched), while clu

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3

Pereira, Joao P., Vivian Lim, Ana Gomes, et al. "Hematopoietic stem cell niches control multipotent progenitor differentiation." Journal of Immunology 196, no. 1_Supplement (2016): 122.1. http://dx.doi.org/10.4049/jimmunol.196.supp.122.1.

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Abstract Hematopoietic stem cells (HSC) self-renew in bone marrow niches formed by CXCL12+ mesenchymal progenitor and endothelial cells. Here, we show that hematopoietic multipotent progenitors (MPPs) encounter lineage-instructive differentiation signals in HSC niches. Conditional deletion of CXCR4 in MPPs profoundly reduced differentiation into common lymphoid progenitors (CLPs), which significantly decreased lymphopoiesis. CXCR4 was required for CLP positioning near IL-7+ cells and, consequently, for optimal IL-7R signaling. IL-7+ cells form a large subset of CXCL12-abundant reticular mesenc

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4

Meier‐Abt, F., S. Amon, L. Gillet, et al. "PF453 TRANSCRIPTOME‐PROTEOME CORRELATION IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS." HemaSphere 3, S1 (2019): 178. http://dx.doi.org/10.1002/j.2572-9241.2019.tb00052.x.

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Background:Hematopoietic stem cells (HSCs) can self‐renew and/or differentiate into various functionally divergent progenitor cell types, such as common myeloid progenitors (CMPs), megakaryocyte‐erythrocyte progenitors (MEPs) or granulocyte‐macrophage progenitors (GMPs). When the process of self‐renewal and differentiation is altered, e.g. upon genetic or epigenetic changes in HSCs, abnormal (pre)leukemic stem cell subpopulations may form, eventually resulting in the onset of hematopoietic malignancies. To gain insight into the physiology and patho‐physiology of self‐renewal and differentiatio

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5

Kuramoto, Ken, Dean A. Follmann, Peiman Hematti, et al. "Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates." Blood 103, no. 11 (2004): 4070–77. http://dx.doi.org/10.1182/blood-2003-08-2934.

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Abstract Hematopoietic cytokines such as filgrastim are used extensively to stimulate granulocyte production or to mobilize hematopoietic progenitors into the circulation; however, their effect on more primitive hematopoietic progenitor and stem cells in vivo is unknown, particularly in large animals or humans. In particular, there is concern that chronic therapy with cytokines could result in stem cell exhaustion or clonal dominance; however, direct assessment of the dynamics of individual stem and progenitor cell clones in vivo has not been previously reported. A number of models can be prop

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6

Qian, Hong, Karl Tryggvason, Sten Eirik Jacobsen та Marja Ekblom. "Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins". Blood 107, № 9 (2006): 3503–10. http://dx.doi.org/10.1182/blood-2005-10-3932.

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The laminin receptor integrin α6 chain is ubiquitously expressed in human and mouse hematopoietic stem and progenitor cells. We have studied its role for homing of stem and progenitor cells to mouse hematopoietic tissues in vivo. A function-blocking anti–integrin α6 antibody significantly reduced progenitor cell homing to bone marrow (BM) of lethally irradiated mice, with a corresponding retention of progenitors in blood. Remarkably, the anti–integrin α6 antibody profoundly inhibited BM homing of long-term multilineage engrafting stem cells, studied by competitive repopulation assay and analys

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Ribatti, Domenico, and Antonio d’Amati. "Hematopoiesis and Mast Cell Development." International Journal of Molecular Sciences 24, no. 13 (2023): 10679. http://dx.doi.org/10.3390/ijms241310679.

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Hematopoietic stem cells (HSCs) are defined based on their capacity to replenish themselves (self-renewal) and give rise to all mature hematopoietic cell types (multi-lineage differentiation) over their lifetime. HSCs are mainly distributed in the bone marrow during adult life, harboring HSC populations and a hierarchy of different kinds of cells contributing to the “niche” that supports HSC regulation, myelopoiesis, and lymphopoiesis. In addition, HSC-like progenitors, innate immune cell precursors such as macrophages, mast cells, natural killer cells, innate lymphoid cells, and megakaryocyte

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8

Camargo, Fernando D. "In vivo Stem Cell Clonal Dynamics." Blood 126, no. 23 (2015): SCI—40—SCI—40. http://dx.doi.org/10.1182/blood.v126.23.sci-40.sci-40.

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Abstract Tremendous progress has been achieved in the characterization of the hematopoietic system over the past two decades. Historically, the main experimental approach used to elucidate and define these cellular relationships in the bone marrow (BM) has been the transplantation assay. For this reason, most of our knowledge about the in vivo properties of hematopoietic stem cells (HSCs) and progenitor cells has been derived from studies in the transplant context. Because of the lack of tractable systems, the mechanistic nature of non-transplant hematopoiesis has remained largely unexplored.

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9

Quesenberry, Peter J., Gerald A. Colvin, and Jean-Francois Lambert. "The chiaroscuro stem cell: a unified stem cell theory." Blood 100, no. 13 (2002): 4266–71. http://dx.doi.org/10.1182/blood-2002-04-1246.

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Hematopoiesis has been considered hierarchical in nature, but recent data suggest that the system is not hierarchical and is, in fact, quite functionally plastic. Existing data indicate that engraftment and progenitor phenotypes vary inversely with cell cycle transit and that gene expression also varies widely. These observations suggest that there is no progenitor/stem cell hierarchy, but rather a reversible continuum. This may, in turn, be dependent on shifting chromatin and gene expression with cell cycle transit. If the phenotype of these primitive marrow cells changes from engraftable ste

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10

Koeniger, Tobias, Luisa Bell, Anika Mifka, et al. "Bone marrow-derived myeloid progenitors in the leptomeninges of adult mice." Stem Cells 39, no. 2 (2020): 227–39. http://dx.doi.org/10.1002/stem.3311.

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Abstract Although the bone marrow contains most hematopoietic activity during adulthood, hematopoietic stem and progenitor cells can be recovered from various extramedullary sites. Cells with hematopoietic progenitor properties have even been reported in the adult brain under steady-state conditions, but their nature and localization remain insufficiently defined. Here, we describe a heterogeneous population of myeloid progenitors in the leptomeninges of adult C57BL/6 mice. This cell pool included common myeloid, granulocyte/macrophage, and megakaryocyte/erythrocyte progenitors. Accordingly, i

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11

Zandi, Sasan, Faiyaz Notta, John E. Dick, et al. "The Human Blood Hierarchy Is Shaped By Distinct Progenitor Lineages Across Development." Blood 126, no. 23 (2015): 2360. http://dx.doi.org/10.1182/blood.v126.23.2360.2360.

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Abstract Background: The hematopoietic roadmap is a compilation of the various lineage differentiation routes that a stem cell takes to make blood. On several occasions over the last six decades, the murine roadmap has been reconceived due to new information overturning old dogmas. The human roadmap, which describes the extraordinary throughput of more than three hundred billion cells daily has changed little, with the classical model of hematopoiesis still prevailing. In this model, blood differentiation initiated at the level of stem cells must pass through a series of increasingly lineage-r

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Kohno, Kentaro, Hiromi Iwasaki, Tadafumi Iino, Shin-ichi Mizuno, Peter Sicinski, and Koichi Akashi. "Cyclin A2 Plays a Critical Role in Proliferation of Lymphoid Progenitors." Blood 118, no. 21 (2011): 914. http://dx.doi.org/10.1182/blood.v118.21.914.914.

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Abstract Abstract 914 Cell cycle regulators could be differentially used among self–renewing stem cells, rapidly expanding progenitor cells, and terminally differentiated cells those clonally replicate. Cyclin A is a regulatory subunit for cyclin dependent kinase (Cdk) 1 and Cdk2, and it drives S phase progression as well as transition to G2/M phase in cell cycle. We have previously reported that cyclin A2 is not required for fibroblast replication but it is indispensable in maintenance of self-renewing stem cells, including embryonic stem cells and hematopoietic stem cells (HSCs) (Cell 138 20

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Buza-Vidas, Natalija, Petter Woll, Anne Hultquist, et al. "FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells." Blood 118, no. 6 (2011): 1544–48. http://dx.doi.org/10.1182/blood-2010-10-316232.

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Abstract Lymphoid-primed multipotent progenitors with down-regulated megakaryocyte-erythroid (MkE) potential are restricted to cells with high levels of cell-surface FLT3 expression, whereas HSCs and MkE progenitors lack detectable cell-surface FLT3. These findings are compatible with FLT3 cell-surface expression not being detectable in the fully multipotent stem/progenitor cell compartment in mice. If so, this process could be distinct from human hematopoiesis, in which FLT3 already is expressed in multipotent stem/progenitor cells. The expression pattern of Flt3 (mRNA) and FLT3 (protein) in

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14

Caplan, Arnold I., and James E. Dennis. "Mesenchymal stem cell progenitor cascade." Matrix Biology 15, no. 3 (1996): 187. http://dx.doi.org/10.1016/s0945-053x(96)90083-9.

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15

Welner, Robert S., Deepak Bararia, Giovanni Amabile та ін. "C/EBPα is required for development of dendritic cell progenitors". Blood 121, № 20 (2013): 4073–81. http://dx.doi.org/10.1182/blood-2012-10-463448.

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16

Keller, U., MJ Aman, G. Derigs, C. Huber, and C. Peschel. "Human interleukin-4 enhances stromal cell-dependent hematopoiesis: costimulation with stem cell factor." Blood 84, no. 7 (1994): 2189–96. http://dx.doi.org/10.1182/blood.v84.7.2189.2189.

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Abstract Interleukin-4 (IL-4) has distinct hematopoietic activities, primarily as a costimulant with other cytokines to enhance colony formation of hematopoietic progenitors. We investigated the influence of IL-4 on stromal cell-supported long-term cultures (LTCs) of normal human bone marrow. Addition of IL-4 to LTCs of unseparated bone marrow or highly enriched CD34+ cells resulted in a significant increase of myeloid progenitors in the nonadherent, as well as in the stromal cell-adherent cell populations. In contrast, the total cell number was not influenced by IL-4, suggesting a selective e

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17

Keller, U., MJ Aman, G. Derigs, C. Huber, and C. Peschel. "Human interleukin-4 enhances stromal cell-dependent hematopoiesis: costimulation with stem cell factor." Blood 84, no. 7 (1994): 2189–96. http://dx.doi.org/10.1182/blood.v84.7.2189.bloodjournal8472189.

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Interleukin-4 (IL-4) has distinct hematopoietic activities, primarily as a costimulant with other cytokines to enhance colony formation of hematopoietic progenitors. We investigated the influence of IL-4 on stromal cell-supported long-term cultures (LTCs) of normal human bone marrow. Addition of IL-4 to LTCs of unseparated bone marrow or highly enriched CD34+ cells resulted in a significant increase of myeloid progenitors in the nonadherent, as well as in the stromal cell-adherent cell populations. In contrast, the total cell number was not influenced by IL-4, suggesting a selective effect on

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18

Tan, Zenglai, Aleksandra Rak-Raszewska, Ilya Skovorodkin, and Seppo J. Vainio. "Mouse Embryonic Stem Cell-Derived Ureteric Bud Progenitors Induce Nephrogenesis." Cells 9, no. 2 (2020): 329. http://dx.doi.org/10.3390/cells9020329.

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Generation of kidney organoids from pluripotent stem cells (PSCs) is regarded as a potentially powerful way to study kidney development, disease, and regeneration. Direct differentiation of PSCs towards renal lineages is well studied; however, most of the studies relate to generation of nephron progenitor population from PSCs. Until now, differentiation of PSCs into ureteric bud (UB) progenitor cells has had limited success. Here, we describe a simple, efficient, and reproducible protocol to direct differentiation of mouse embryonic stem cells (mESCs) into UB progenitor cells. The mESC-derived

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Teerds, Katja J., Eddy Rijntjes, Margarita B. Veldhuizen-Tsoerkan, Focko F. G. Rommerts, and Mieke de Boer-Brouwer. "The development of rat Leydig cell progenitors in vitro: how essential is luteinising hormone?" Journal of Endocrinology 194, no. 3 (2007): 579–93. http://dx.doi.org/10.1677/joe-06-0084.

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Luteinising hormone (LH) appears to be important for the establishment of the adult-type Leydig cell population. The role of LH in the initial steps of stem Leydig cell/precursor cell differentiation is less clear. The aim of the present study was to elucidate the role of LH in the differentiation of spindle-shaped mesenchymal-like cells into Leydig cell progenitors. Interstitial cells were isolated from rat testes at three different ages reflecting different phases in development, and cultured in the presence of increasing concentrations of LH (ranging from 0.01 to 10 ng/ml). Cells were isola

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20

Chan, Charles, Ching-Cheng Chen, Daniel L. Kraft, et al. "Identification and Isolation of the Hematopoietic Stem Cell Niche Initiating Cell Population." Blood 112, no. 11 (2008): 3574. http://dx.doi.org/10.1182/blood.v112.11.3574.3574.

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Abstract Introduction: Identification and understanding of the cells and processes that can generate, sustain and influence the HSC niche and hematopoiesis are critical for the development of a more comprehensive knowledge of normal hematopoiesis, stem cell homing, trafficking, differentiation and hematopoietic pathology. Growth and renewal in many tissues are initiated by stem cells, supported by the microenvironment (niche) in which they reside. While recent work has begun to describe functional interactions between stem cells and their niches, little is known about the formation of stem cel

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Carlo-Stella, C., and V. Rizzoli. "In Vitro Manipulation of Peripheral Blood Progenitor Cell Collections." International Journal of Artificial Organs 21, no. 6_suppl (1998): 1–10. http://dx.doi.org/10.1177/039139889802106s01.

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Mobilized peripheral blood progenitor cells (PBPC) are increasingly used to reconstitute hematopoiesis in patients undergoing high-dose chemoradiotherapy. PBPC collections comprise a heterogeneous population containing both committed progenitors and pluripotent stem cells and can be harvested (i) in steady state, (ii) after chemotherapeutic conditioning, (iii) growth factor priming, or (iv) both. The use of PBPC has opened new therapeutic perspectives mainly related to the availability of large amounts of mobilized hematopoietic stem and progenitor cells. Extensive manipulation of the grafts,

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Trowbridge, Jennifer J., Jonathan W. Snow, Jonghwan Kim, and Stuart H. Orkin. "DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells." Blood 114, no. 22 (2009): 392. http://dx.doi.org/10.1182/blood.v114.22.392.392.

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Abstract Abstract 392 DNA methylation is essential for development and plays crucial roles in a variety of biological processes. The DNA methyltransferase Dnmt1 serves to maintain parental cell methylation patterns on daughter DNA strands in mitotic cells, however, the precise role of Dnmt1 in regulation of quiescent adult stem cells is not known. To examine the role of Dnmt1 in adult hematopoietic stem cells (HSCs), we crossed Dnmt1fl/fl mice with Mx1-Cre transgenic mice, and by injection of poly(I)-poly(C) we selectively deleted Dnmt1 in the hematopoietic system (Dnmt1Δ/Δ). In Dnmt1Δ/Δ mice,

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Ivanov, Martin N., Dimo S. Stoyanov, Lora V. Veleva, et al. "TNC and GJA1 Are Putative Progenitor Markers That Are Localized in the Perivascular Adventitia of the Adult Monkey Brain Subventricular Niche." International Journal of Molecular Sciences 26, no. 4 (2025): 1397. https://doi.org/10.3390/ijms26041397.

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The largest area in the adult mammalian brain that contains stem and progenitor cells at different stages of differentiation is the subventricular zone located along the lateral wall of the lateral ventricle. We have previously shown in adult monkeys that transient global cerebral ischemia upregulates the expression of hundreds of genes in this zone, including genes known to be related to stemness in the rodent brain. Here, we analyzed the immunophenotype of two of these genes, TNC and GJA1, by co-expression experiments, applying a panel of known stem/progenitor-cell-related markers. We found

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Li, June, Daniel P. Sejas, and Qishen Pang. "Nucleophosmin Regulates Differentiation, Cell Cycle Progression, and Stress Response in Hematopoietic Progenitor Cells." Blood 106, no. 11 (2005): 312. http://dx.doi.org/10.1182/blood.v106.11.312.312.

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Abstract Nucleophosmin (NPM) is a multifunctional protein frequently overexpressed in actively proliferating cells including tumor and hematopoietic stem cells. Strong evidence indicates that NPM is involved in hematopoiesis and leukemic development. Here we report that NPM enhances the proliferative potential of hematopoietic stem/progenitor cells and increases cell survival upon stress challenge. Specifically, lin-Sca1+c-kit+ bone marrow cells transduced with retroviral vector expressing NPM exhibited higher proliferative rates in both short-term liquid culture and clonogenic progenitor cell

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Woolthuis, Carolien M., and Christopher Y. Park. "Hematopoietic stem/progenitor cell commitment to the megakaryocyte lineage." Blood 127, no. 10 (2016): 1242–48. http://dx.doi.org/10.1182/blood-2015-07-607945.

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Abstract The classical model of hematopoiesis has long held that hematopoietic stem cells (HSCs) sit at the apex of a developmental hierarchy in which HSCs undergo long-term self-renewal while giving rise to cells of all the blood lineages. In this model, self-renewing HSCs progressively lose the capacity for self-renewal as they transit into short-term self-renewing and multipotent progenitor states, with the first major lineage commitment occurring in multipotent progenitors, thus giving rise to progenitors that initiate the myeloid and lymphoid branches of hematopoiesis. Subsequently, withi

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Kristensen, Helene Bjoerg, Thomas Levin Andersen, Andrea Patriarca, et al. "Human hematopoietic microenvironments." PLOS ONE 16, no. 4 (2021): e0250081. http://dx.doi.org/10.1371/journal.pone.0250081.

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Dormancy of hematopoietic stem cells and formation of progenitors are directed by signals that come from the bone marrow microenvironment. Considerable knowledge has been gained on the murine hematopoietic stem cell microenvironment, while less so on the murine progenitor microenvironment and even less so on these microenvironments in humans. Characterization of these microenvironments is decisive for understanding hematopoiesis and finding new treatment modalities against bone marrow malignancies in the clinic. However, it is equally challenging, because hematopoietic stem cells are difficult

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Baljevic, Muhamed, Sergey V. Shmelkov, Daniel J. Nolan, et al. "Endothelial Progenitor Cell Marker CD133 Identifies Tumor Endothelium." Blood 112, no. 11 (2008): 5449. http://dx.doi.org/10.1182/blood.v112.11.5449.5449.

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Abstract CD133, a pentaspan surface antigen, is considered a marker of tissue-specific stem cells, including hematopoietic stem cells and endothelial progenitors. We and others have previously shown that CD133 expression is high on endothelial progenitor cells; that it is downregulated during their differentiation and that it is not found on mature endothelium. In addition, CD133+ cells in brain tumors were shown to exhibit features of cancer stem cells. Recent report showed that CD133+ tumor cells are located in perivascular niches in astrocytomas and glioblastomas. It was also demonstrated t

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Dalmaso, Barbara, Ildefonso Alves da Silva-Junior, Sonia Jancar, and Carolina Beltrame Del Debbio. "Platelet-Activating Factor Receptor (PAFR) Regulates Retinal Progenitor/Stem Cells Profile in Ciliary Epithelium Cells." International Journal of Molecular Sciences 25, no. 6 (2024): 3084. http://dx.doi.org/10.3390/ijms25063084.

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The retina is a central nervous tissue essential to visual perception and highly susceptible to environmental damage. Lower vertebrate retinas activate intrinsic regeneration mechanisms in response to retinal injury regulated by a specialized population of progenitor cells. The mammalian retina does not have populations of progenitor/stem cells available to activate regeneration, but contains a subpopulation of differentiated cells that can be reprogrammed into retinal stem cells, the ciliary epithelium (CE) cells. Despite the regenerative potential, stem cells derived from CE exhibit limited

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Yoder, Mervin C. "Endothelial stem and progenitor cells (stem cells): (2017 Grover Conference Series)." Pulmonary Circulation 8, no. 1 (2017): 204589321774395. http://dx.doi.org/10.1177/2045893217743950.

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The capacity of existing blood vessels to give rise to new blood vessels via endothelial cell sprouting is called angiogenesis and is a well-studied biologic process. In contrast, little is known about the mechanisms for endothelial cell replacement or regeneration within established blood vessels. Since clear definitions exist for identifying cells with stem and progenitor cell properties in many tissues and organs of the body, several groups have begun to accumulate evidence that endothelial stem and progenitor cells exist within the endothelial intima of existing blood vessels. This paper w

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Theise, Neil D. "Gastrointestinal Stem Cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity." American Journal of Physiology-Gastrointestinal and Liver Physiology 290, no. 2 (2006): G189—G193. http://dx.doi.org/10.1152/ajpgi.00041.2005.

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This essay will address areas of liver stem/progenitor cell studies in which consensus has emerged and in which controversy still prevails over consensus, but it will also highlight important themes that inevitably should be a focus of liver stem/progenitor cell investigations in coming years. Thus concepts regarding cell plasticity, the existence of a physiological/anatomic stem cell niche, and whether intrahepatic liver stem/progenitor cells comprise true stem cells or progenitor cells (or both) will be approached in some detail.

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Mathur, Divya, Alyssa Bost, Ian Driver, and Benjamin Ohlstein. "A Transient Niche Regulates the Specification of Drosophila Intestinal Stem Cells." Science 327, no. 5962 (2010): 210–13. http://dx.doi.org/10.1126/science.1181958.

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Stem cell niches are locations where stem cells reside and self-renew. Although studies have shown how niches maintain stem cell fate during tissue homeostasis, less is known about their roles in establishing stem cells. The adult Drosophila midgut is maintained by intestinal stem cells (ISCs); however, how they are established is unknown. Here, we show that an ISC progenitor generates a niche cell via Notch signaling. This niche uses the bone morphogenetic protein 2/4 homolog, decapentaplegic, to allow progenitors to divide in an undifferentiated state and subsequently breaks down and dies, r

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Bardelli, Silvana, and Marco Moccetti. "Stem and Progenitor Cells in Human Cardiopulmonary Development and Regeneration." Stem Cells International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/2653142.

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Already during embryonic development, the heart and the lung are thoroughly connected organs. Their interdependence allows our survival in the terrestrial environment by coupling cardiac output and gas exchange. The knowledge on developmental processes involving stem and progenitor cells is crucial to understand the onset of human cardiopulmonary diseases. The precise identification of various adult endogenous progenitors is still incomplete. Thus, caution should be exercised on newly available stem cell-based treatments until specific mechanisms of action are disclosed. The objective is to pr

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May, Randal, Sripathi M. Sureban, Stan A. Lightfoot, et al. "Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas." American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 2 (2010): G303—G310. http://dx.doi.org/10.1152/ajpgi.00146.2010.

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Stem cells are critical in maintaining adult homeostasis and have been proposed to be the origin of many solid tumors, including pancreatic cancer. Here we demonstrate the expression patterns of the putative intestinal stem cell marker DCAMKL-1 in the pancreas of uninjured C57BL/6 mice compared with other pancreatic stem/progenitor cell markers. We then determined the viability of isolated pancreatic stem/progenitor cells in isotransplantation assays following DCAMKL-1 antibody-based cell sorting. Sorted cells were grown in suspension culture and injected into the flanks of athymic nude mice.

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Cheng, J., S. Baumhueter, G. Cacalano, et al. "Hematopoietic defects in mice lacking the sialomucin CD34." Blood 87, no. 2 (1996): 479–90. http://dx.doi.org/10.1182/blood.v87.2.479.bloodjournal872479.

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Although the pluripotent hematopoietic stem cell can only be definitively identified by its ability to reconstitute the various mature blood lineages, a diversity of cell surface antigens have also been specifically recognized on this subset of hematopoietic progenitors. One such stem cell-associated antigen is the sialomucin CD34, a highly O-glycosylated cell surface glycoprotein that has also been shown to be expressed on all vascular endothelial cells throughout murine embryogenesis as well as in the adult. The functional significance of CD34 expression on hematopoietic progenitor cells and

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Velu, Chinavenmeni S., Michael Berk, Haiming Xu, et al. "The Ski oncoprotein regulates Hematopoietic Stem Cell Fitness and Functions as a Corepressor for Gfi1." Blood 112, no. 11 (2008): 1403. http://dx.doi.org/10.1182/blood.v112.11.1403.1403.

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Abstract Ski is a corepressor protein originally identified as a retrovirally transduced oncoprotein. Genetic deletion of Ski has revealed essential roles in multiple developmental processes. Suggestion that Ski may play a role in hematopoiesis first came from expression of v-Ski and c-Kit, which induced the continuous in vitro growth of primary avian multipotent progenitors. However, the hematopoietic phenotype of Ski−/− mice has not been described. Here, we show that Ski loss of function results in loss of hematopoietic stem cell (HSC) fitness and abnormal regulation of myeloid progenitor nu

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Hirabayashi, Yoko, Byung-Il Yoon, Isao Tsuboi, et al. "The Cell Cycle in Hematopoietic Stem Cells, Lin−/C-kit+/Sca1+ Fraction, Is Regulated by Connexin 32, Specifically Expressed in the Stem Cell Compartment." Blood 112, no. 11 (2008): 4775. http://dx.doi.org/10.1182/blood.v112.11.4775.4775.

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Abstract Connexin (Cx) functions in the organization of cell-cell communication via gap junctions in multicellular organisms. Gap junctions have been implicated in the homeostatic regulation of various cellular functions, including growth control, cellular differentiation, apoptosis and the synchronization of electrotonic and metabolic functions. As Cxs are essential molecules for multicellular organisms, Cxs that organize cell-cell communication within the hematopoietic progenitor cell compartment are surmised to be present in bone marrow tissue. Recently, we first found that Cx32 is only Cx

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Qian, Hong, Sten Eirik W. Jacobsen, and Marja Ekblom. "Involvement of the Integrin Alpha 6 Receptor in the Homing and Engraftment of Hematopoietic Stem and Progenitor Cells to Bone Marrow." Blood 104, no. 11 (2004): 1293. http://dx.doi.org/10.1182/blood.v104.11.1293.1293.

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Abstract Within the bone marrow environment, adhesive interactions between stromal cells and extracellular matrix molecules are required for stem and progenitor cell survival, proliferation and differentiation as well as their transmigration between bone marrow (BM) and the circulation. This regulation is mediated by cell surface adhesion receptors. In experimental mouse stem cell transplantation models, several classes of cell adhesion receptors have been shown to be involved in the homing and engraftment of stem and progenitor cells in BM. We have previously found that integrin a6 mediates h

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Kohno, Kentaro, Tadafumi Iino, Kyoko Ito, Shin-ichi Mizuno, Piotr Sicinski, and Koichi Akashi. "Cyclin A2 Plays a Critical Role Not Only in Self-Renewal of Hematopoietic Stem Cells, but Also in Non-Self-Renewing Proliferation of Lymphoid Progenitors." Blood 114, no. 22 (2009): 381. http://dx.doi.org/10.1182/blood.v114.22.381.381.

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Abstract Abstract 381 Cyclins are regulatory subunits of cyclin-dependent kinase, and are important components of cell cycle engine. The A-type cyclin is generally the S-phase cyclin. Mammalian cells express two A-type cyclins, including cyclin A1 that is exclusively expressed in the testis, and cyclin A2 whose expression is ubiquitous. We have recently reported that cyclin A2 is not required for fibroblast proliferation but it is indispensable in maintenance of self-renewal of stem cells, including embryonic stem cells and hematopoietic stem cells (HSCs) (Cell 138 2009). The question is wheth

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Farrugia, Georgiana, and Rena Balzan. "Stem Cell Repair for Cardiac Muscle Regeneration: A Review of the Literature." International Journal of Medical Students 4, no. 1 (2016): 19–25. http://dx.doi.org/10.5195/ijms.2016.145.

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The notion that the human adult heart is a quiescent organ incapable of self-regeneration has been successfully challenged. It is now evident that the heart possesses a significant ability for repair and regeneration. Stem cells of endogenous cardiac origin are currently considered to possess the greatest ability to differentiate into cardiomyocytes. The major types of cardiac stem cells that show a promising potential to replace damaged cardiomyocytes include C-KIT positive (C-KIT+) cardiac progenitor cells, cardiosphere-derived progenitor cells, islet-1 (Isl1+) cardiac progenitor cells, side

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Huang, Grace, Venkata Naga Srikanth Garikipati, Yan Zhou, et al. "Identification and Comparison of Hyperglycemia-Induced Extracellular Vesicle Transcriptome in Different Mouse Stem Cells." Cells 9, no. 9 (2020): 2098. http://dx.doi.org/10.3390/cells9092098.

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Extracellular vesicles (EVs) derived from stem /progenitor cells harbor immense potential to promote cardiomyocyte survival and neovascularization, and to mitigate ischemic injury. However, EVs’ parental stem/progenitor cells showed modest benefits in clinical trials, suggesting autologous stem cell/EV quality might have been altered by stimuli associated with the co-morbidities such as hyperglycemia associated with diabetes. Hyperglycemia is a characteristic of diabetes and a major driving factor in cardiovascular disease. The functional role of stem/progenitor cell-derived EVs and the molecu

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Chan, Mike K. S., Michelle B. F. Wong, Shing Yi Pan, et al. "Carcinogenicity And Oncogenicity of Precursor/Progenitor Stem Cells of the Xenogeneic Origin: The Balb/C-3t3 Cell Transformation Assay." SSP Modern Pharmacy and Medicine 3, no. 5 (2025): 20. https://doi.org/10.53933/61x4gw93.

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Stem cell-based therapies represent a transformative advancement in regenerative medicine, offering unprecedented opportunities to restore, replace, or regenerate damaged tissues and organs. Among these, xenogeneic cell therapy—utilizing cells derived from non-human animal sources—has shown therapeutic potential in both preclinical and early clinical settings. Functional improvements have been demonstrated with xenogeneic hepatocytes, pancreatic islet cells, and neural progenitors, highlighting their promise for treating organ dysfunction and degenerative conditions. However, concerns remain r

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Aguilar-Sanchez, Cristina, Melina Michael, and Sari Pennings. "Cardiac Stem Cells in the Postnatal Heart: Lessons from Development." Stem Cells International 2018 (June 24, 2018): 1–13. http://dx.doi.org/10.1155/2018/1247857.

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Heart development in mammals is followed by a postnatal decline in cell proliferation and cell renewal from stem cell populations. A better understanding of the developmental changes in cardiac microenvironments occurring during heart maturation will be informative regarding the loss of adult regenerative potential. We reevaluate the adult heart’s mitotic potential and the reported adult cardiac stem cell populations, as these are two topics of ongoing debate. The heart’s early capacity for cell proliferation driven by progenitors and reciprocal signalling is demonstrated throughout developmen

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Mun, Seyoung, Seong Min Kim, Min-Jeong Choi, and Young-Joo Jang. "Transcriptome Profile of Membrane and Extracellular Matrix Components in Ligament-Fibroblastic Progenitors and Cementoblasts Differentiated from Human Periodontal Ligament Cells." Genes 13, no. 4 (2022): 659. http://dx.doi.org/10.3390/genes13040659.

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Ligament-fibroblastic cells and cementoblasts, two types of progenitor cells that differentiate from periodontal ligament stem cells (hPDLSCs), are responsible for the formation of the adhesive tissues in the tooth root. Since one of the factors that determines the fate of stem cell differentiation is the change in the microenvironment of the stem/progenitor cells, this study attempted to compare and analyze the molecular differences in the membrane and ECM of the two progenitor cells. Single cells derived from hPDLSCs were treated with TGF-β1 and BMP7 to obtain ligament-fibroblastic and cemen

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Golan, Karin, Yaron Vagima, Aya Ludin, et al. "S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release." Blood 119, no. 11 (2012): 2478–88. http://dx.doi.org/10.1182/blood-2011-06-358614.

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Abstract The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate (S1P) receptors by FTY720 as well as disruption of S1P gradient toward the blood, reduced steady state egress of immature progenitors and primitive Sca-1+/c-Kit+/Lin− (SKL) cells via inhibition of SDF-1 release. Administration of AMD3100 or G-CSF to mice with deficiencies in either S1P production or its receptor S1P1, or pretreated with FTY720, also resulted in reduced stem and progenitor cell mobilization.

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Walasek, Marta A., Leonid Bystrykh, Vincent van den Boom, et al. "The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation." Blood 119, no. 13 (2012): 3050–59. http://dx.doi.org/10.1182/blood-2011-08-375386.

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Abstract Despite increasing knowledge on the regulation of hematopoietic stem/progenitor cell (HSPC) self-renewal and differentiation, in vitro control of stem cell fate decisions has been difficult. The ability to inhibit HSPC commitment in culture may be of benefit to cell therapy protocols. Small molecules can serve as tools to manipulate cell fate decisions. Here, we tested 2 small molecules, valproic acid (VPA) and lithium (Li), to inhibit differentiation. HSPCs exposed to VPA and Li during differentiation-inducing culture preserved an immature cell phenotype, provided radioprotection to

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Hou, Luqia, Joseph J. Kim, Y. Joseph Woo, and Ngan F. Huang. "Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 4 (2016): H455—H465. http://dx.doi.org/10.1152/ajpheart.00726.2015.

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Stem cell therapy is a promising approach for the treatment of tissue ischemia associated with myocardial infarction and peripheral arterial disease. Stem and progenitor cells derived from bone marrow or from pluripotent stem cells have shown therapeutic benefit in boosting angiogenesis as well as restoring tissue function. Notably, adult stem and progenitor cells including mononuclear cells, endothelial progenitor cells, and mesenchymal stem cells have progressed into clinical trials and have shown positive benefits. In this review, we overview the major classes of stem and progenitor cells,

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Sun, Qian, Chi-Chiu So, Sze-Fai Yip, Thomas S. K. Wan, Edmond Shiu Kwan Ma, and LiChong Chan. "Functional Alterations of Lin−CD34+CD38+ Progenitors in Chronic Myelomonocytic Leukaemia and on Progression to Acute Leukaemia." Blood 110, no. 11 (2007): 4119. http://dx.doi.org/10.1182/blood.v110.11.4119.4119.

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Abstract Chronic myelomonocytic leukaemia (CMML) is a clonal bone marrow stem cell disorder based on the presence of trilineage involvement, the association of myelodysplastic and myeloproliferative features and its ability to transform into acute myeloid leukaemia. The objectives of our study are to identify the cell population and its functional characteristics involved in evolution from CMML phase to acute myeloid leukaemia. We analysed Lin−CD34+ stem/progenitor population and performed cell proliferation, apoptotic assays, self-renewal ability and differentiation potential studies in purif

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Borge, Ole J., Veslemøy Ramsfjell, Li Cui, and Sten E. W. Jacobsen. "Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38− Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin." Blood 90, no. 6 (1997): 2282–92. http://dx.doi.org/10.1182/blood.v90.6.2282.

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Abstract Purified primitive progenitor/stem cells from bone marrow represent likely target populations for ex vivo expansion of stem cells to be used in high-dose chemotherapy or gene therapy. Whereas such primitive progenitor cells require combined stimulation by multiple cytokines for growth, some cytokines selectively promote viability rather than growth when acting individually. We investigated here for the first time the direct effects of cytokines on survival of primitive CD34+CD38− human bone marrow progenitor cells at the single-cell level. Interleukin-3 (IL-3) and the ligands for c-ki

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Borge, Ole J., Veslemøy Ramsfjell, Li Cui, and Sten E. W. Jacobsen. "Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38− Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin." Blood 90, no. 6 (1997): 2282–92. http://dx.doi.org/10.1182/blood.v90.6.2282.2282_2282_2292.

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Purified primitive progenitor/stem cells from bone marrow represent likely target populations for ex vivo expansion of stem cells to be used in high-dose chemotherapy or gene therapy. Whereas such primitive progenitor cells require combined stimulation by multiple cytokines for growth, some cytokines selectively promote viability rather than growth when acting individually. We investigated here for the first time the direct effects of cytokines on survival of primitive CD34+CD38− human bone marrow progenitor cells at the single-cell level. Interleukin-3 (IL-3) and the ligands for c-kit (KL) an

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50

Olweus, J., LW Terstappen, PA Thompson, and F. Lund-Johansen. "Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells." Blood 88, no. 5 (1996): 1594–607. http://dx.doi.org/10.1182/blood.v88.5.1594.1594.

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Abstract The aim of the present study was to determine whether stem cell factor (SCF) and erythropoietin (EPO) act differently on defined subsets of progenitor cells, and if potential differences correlate with the receptor density on each subset. To investigate this possibility directly, we optimized conditions for the identification and purification of homogeneous progenitor cell subpopulations from human bone marrow. Populations containing 40% and 44% colony forming cells (CFCs) with 99% and 95% purity for the granulomonocytic and erythroid lineage, respectively, were sorted on the basis of

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