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Journal articles on the topic 'Structure of rat heart'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

PIPER, RICHARD D, FU YAN LI, MARY LEE MYERS, and WILLIAM J SIBBALD. "Structure–Function Relationships in the Septic Rat Heart." American Journal of Respiratory and Critical Care Medicine 156, no. 5 (1997): 1473–82. http://dx.doi.org/10.1164/ajrccm.156.5.96-10085.

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2

Sotnichenko, A. S., E. A. Gubareva, I. V. Gilevich, et al. "Decellularized rat heart matrix as a basis for creation of tissue engineered heart." Genes & Cells 8, no. 3 (2013): 86–94. http://dx.doi.org/10.23868/gc120548.

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Development of bioengineered scaffolds of internal organs is one of the priority areas of tissue engineering. Decellularization allows to obtain biological (natural) scaffolds while preserving extracellular matrix and three-dimensional structure of organs. The primary goals of the present research were to investigate pathological characteristics of the decellularized rat heart scaffold and evaluate adhesion and viability of multipotent mesenchymal stromal cells (MMSC) during recellularization. Rat hearts were decellularized using a modified detergent-enzymatic method including sodium deoxychol

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3

Mansurova, Dilorom Aslanovna. "MORPHOLOGICAL ASPECTS OF THE STRUCTURE OF THE VENTRICULAR AND ATRIUM MYOCARDIUM." ORIENTAL JOURNAL OF MEDICINE AND NATURAL SCIENCES 1, no. 1 (2024): 11–18. https://doi.org/10.5281/zenodo.10526484.

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The purpose of our work was to identify the features of morphogenesis in postnatal ontogenesis, to study the histological structure of different parts and membranes of the heart of rat pups on days 1-22 after birth. The object of the study was the heart of 50 rat pups on days 1, 6, 11, 16, and 22 after birth. There is an alternation of periods of accelerated and slow increases in the growth rate of the thickness of the atrium and ventricles. The thickness of the endocardium and epicardium increases less significantly. The growth rate of ventricular myocardial thickness is observed in rat pups

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4

Kornjaca, Dusko, Vladimir Jakovljevic, Stefan Zivkovic, Marko Djuric, Nela Puskas, and Dragan Djuric. "The Effects of Acute Vibroacoustic Microvibrations on the Rat Heart Rate, Rhythm and Structure / Efekti Akutne Primene Vibroakustičkih Mikrovibracija Na Frekvenciju, Ritam I Strukturu Srca Pacova." Serbian Journal of Experimental and Clinical Research 15, no. 4 (2014): 191–96. http://dx.doi.org/10.2478/sjecr-2014-0024.

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ABSTRACT The body surface of homeothermic organisms produces constant microvibrations. In the past, many studies were conducted on this topic, and the amplitude of the microvibrations was described as a sensitive marker of muscle tension and body activity. Subsequent studies indicated that the frequency of the microvibrations is an important variable affecting the body. The aim of this research was to examine the effects of the vibroacoustic microvibrations on the rate, rhythm and structure of the rat heart during physiological conditions. Microvibrations of specific frequency and amplitude we

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Gilbert, Stephen H., David Benoist, Alan P. Benson, et al. "Visualization and quantification of whole rat heart laminar structure using high-spatial resolution contrast-enhanced MRI." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 1 (2012): H287—H298. http://dx.doi.org/10.1152/ajpheart.00824.2011.

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It has been shown by histology that cardiac myocytes are organized into laminae and this structure is important in function, both influencing the spread of electrical activation and enabling myocardial thickening in systole by laminar sliding. We have carried out high-spatial resolution three-dimensional MRI of the ventricular myolaminae of the entire volume of the isolated rat heart after contrast perfusion [dimeglumine gadopentate (Gd-DTPA)]. Four ex vivo rat hearts were perfused with Gd-DTPA and fixative and high-spatial resolution MRI was performed on a 9.4T MRI system. After MRI, cryosect

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6

Huang, He, Yuan Liu, Qiang Su, and Jiayuan Ling. "Overexpression of Homeobox Containing1 Relieves Myocardial Fibrosis and Inflammation in Diabetic Cardiomyopathy Rats." Journal of Biomedical Nanotechnology 19, no. 11 (2023): 2005–12. http://dx.doi.org/10.1166/jbn.2023.3697.

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This study aimed to investigate the impact of Homeobox containing1 (HMBOX1) on heart structure and function in Diabetic Cardiomyopathy (DCM) rats. DCM is the leading cause of death in diabetic patients, significantly affecting their quality of life. The DCM rat model was created using a high-fat diet and streptozotocin injection. The success of the model was determined by assessing heart weight, diet, urine output, and cardiac function. HMBOX1 expression in cardiomyocytes of normal and DCM rats was compared. HMBOX1 expression was enhanced in DCM rat cardiomyocytes through jugular vein injectio

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Zhang, Ying, Li Li, Weiling Wang, Man Li, Aihong Cao, and Yanyan Hu. "Antiapoptotic Effect of Target Protein for Xklp2 on Diabetic Rat Cardiomyocytes." Journal of Biomedical Nanotechnology 20, no. 5 (2024): 878–86. http://dx.doi.org/10.1166/jbn.2024.3832.

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This study investigates the potential of TPX2 in mitigating diabetic cardiomyopathy by modulating the Akt/FoxO1 signaling pathway. Diabetic cardiomyopathy was induced in rats using streptozotocin, and heart structure and function were assessed through echocardiography and HE staining. TPX2 expression in myocardial tissue was measured using qRT-PCR. Lentivirus was used to overexpress TPX2 specifically in myocardial tissue, followed by reassessment of cardiac structure and function. Immunohistochemical staining was employed to evaluate Caspase3 expression. In the diabetic cardiomyopathy group, r

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8

Carver, W., R. L. Price, D. S. Raso, L. Terracio, and T. K. Borg. "Distribution of beta-1 integrin in the developing rat heart." Journal of Histochemistry & Cytochemistry 42, no. 2 (1994): 167–75. http://dx.doi.org/10.1177/42.2.8288862.

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Cell-cell and cell-matrix interactions play critical roles in various developmental processes including differentiation, proliferation, and migration. Members of the integrin family of cell surface components are important mediators of these cell-extracellular matrix (ECM) contacts or interactions. The ECM provides signals to individual cells essential for development and differentiation and plays essential roles in establishing and maintaining the complex structure of the vertebrate heart. Integrins provide a fundamental link for transduction of developmental signals to cells. Integrin expres

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9

Mannella, C. A., A. Ribeiro, B. Cognon, and D. D'Arcangelis. "Structure of paracrystalline arrays on outer membranes of rat-liver and rat-heart mitochondria." Journal of Structural Biology 108, no. 3 (1992): 227–37. http://dx.doi.org/10.1016/1047-8477(92)90023-4.

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10

Kamalovna, Sagdullayeva Makhmuda, Ibragimova Shahzoda Abdurahimovna, and Tolmasov Ruzibek. "MORPHOLOGICAL CHARACTERISTICS OF MYOCARDIAL CHANGES WHEN EXPOSED TO PESTICIDES." American Journal Of Biomedical Science & Pharmaceutical Innovation 03, no. 02 (2023): 17–23. http://dx.doi.org/10.37547/ajbspi/volume03issue01-03.

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The aim of our work is to identify features of morphogenesis in postnatal development, the study of the histological structure of different departments and membranes of rat heart at 1-22 days after birth. The object of the study was the heart of the 50 rats at 1, 6, 11, 16, 22 days after birth. Notes alternating periods of acceleration and deceleration of the growth rate increasing thickness of the atria and ventricles. Endocardial and epicardial thickness increases significantly less. The growth rate of the thickness of the ventricular myocardium were observed in rats 6 and 16 days of age. St

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11

Oguro, Tatsuo, Kaoru Aihara, Kuniharu Aida, Goro Asano, and Muhammad Ashraf. "Ultrastructural change of the cell membranes on myocardium following treatment with H2O2." Proceedings, annual meeting, Electron Microscopy Society of America 51 (August 1, 1993): 356–57. http://dx.doi.org/10.1017/s0424820100147624.

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It has been suggested that hydrogen peroxide (H2O2) is indirectly associated with postischemicreperfusion injury of the heart. Previously, we reported that the heart was not damaged when perfused with exogenously generated superoxide anions. However, H2O2 which is a dismutation product of superoxide anion severely affected the heart structure and function, and the combined effects of H2O on membrane lipid and proteins result in the formation of membranous bleb.In this study, we evaluated the ultrastructural changes of the cell membranes in isolated rat hearts and cultured myocytes following tr

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12

ROSEN, P., and R. ROSEN. "Function, structure, and metabolism of rat heart in non-ketotic diabetes." Journal of Molecular and Cellular Cardiology 19 (1987): S80. http://dx.doi.org/10.1016/s0022-2828(87)80248-1.

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13

Weisberg, Andrea, and Saul Winegrad. "Relation Between Crossbridge Structure and Actomyosin ATPase Activity in Rat Heart." Circulation Research 83, no. 1 (1998): 60–72. http://dx.doi.org/10.1161/01.res.83.1.60.

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14

Mil'to, I. V., and I. V. Sukhodolo. "THE STRUCTURE OF LIVER, LUNG, KIDNEYS, HEART AND SPLEEN OF RATS AFTER REPEATED INTRAVENOUS APPLICATION OF NANOPARTICLES MAGNETITE." Annals of the Russian academy of medical sciences 67, no. 3 (2012): 75–79. http://dx.doi.org/10.15690/vramn.v67i3.189.

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Effects of multiple intravenous magnetite nanosuspension injections on the structure of rat liver, lungs, kidney, heart and spleen have been studied. Histology of the organs listed have found haemodynamic distortions and necrotic lesions in the parenchyma of these organs. With the help of Pearls histochemical method significant piling of nanoparticles were found in the cells of the mononuclear phagocytes in liver, lungs and spleen of the rats. Only singular Pearls-positive cells were found in kidneys and hearts of the rats.

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15

Oguro, T., K. Aida, T. Onodera, and M. Ashraf. "Ultrastructural effects of exogenous hydrogen peroxide on the myocardium." Proceedings, annual meeting, Electron Microscopy Society of America 47 (August 6, 1989): 1102–3. http://dx.doi.org/10.1017/s0424820100157498.

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It has been suggested that hydrogen peroxide (H2O2) is indirectly associated with postischemic-reperfusion injury of the heart. Previously, we reported that the heart was not damaged when perfused with exogenously generated superoxide anions. However, H2O2, a dismutation product of superoxide anion severely affected the heart structure and function. In this study, we evaluated the ultrastructural changes of the cel1 membranes in isolated rat hearts and cultured myocytes follow-ing treatment with exogenous H2O2.In the isolated hearts, 300 μM of H2O2, a concentration which was based on our earli

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16

Kapelko, V. I., A. A. Abramov, and V. L. Lakomkin. "Analysis of Relaxation Phase in the Rat Heart." Российский физиологический журнал им И М Сеченова 109, no. 10 (2023): 1489–97. http://dx.doi.org/10.31857/s0869813923100060.

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The rate and depth of myocardial relaxation determine left ventricular (LV) filling in early diastole. To analyze the relaxation phase, the method of logarithm of LV pressure fall in rats was used. A gradual acceleration of relaxation was found during the transition from the isovolumic phase to the auxovolumic phase, immediately before the opening of the atrioventricular valves. The relaxation rate constant in this phase has been inversely correlated with the values of the minimum LV diastolic pressure and LV endsystolic volume. The results suggest that the gradual acceleration of relaxation i

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17

Waleczek, Florian J. G., Giuseppe Cipriano, Jonas A. Haas, et al. "Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure." International Journal of Molecular Sciences 26, no. 1 (2024): 218. https://doi.org/10.3390/ijms26010218.

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Ischemic heart disease is the leading cause of death worldwide. Reduced oxygen supply and myocardial hypoxia lead to tissue damage and impairment of the heart function. To the best of our knowledge, the primary functional effects of hypoxia in the multicellular model of living myocardial slices (LMSs) have not been investigated so far. In this study, we analyzed force generation, ultrastructure, gene expression, and proteome changes in rat LMS after 24 h of ex vivo culture in normal and reduced levels of oxygen (O2). We observed a significant reduction in absolute force and a slowdown of force

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18

ABADI, SELMA ALAMANDA, ZULFA ILLIYYIN, JASMINE RAISSA RACHMADINA, and DESAK MADE MALINI. "The effect of jengkol (Archidendron pauciflorum) fruit peel ethanolic extract to heart histologic of rat induced by streptozotocin." Biofarmasi Journal of Natural Product Biochemistry 16, no. 2 (2018): 59–63. http://dx.doi.org/10.13057/biofar/f160201.

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Abadi SA, Illiyyin Z, Rachmadina JR, Malini DM. 2018. The effect of jengkol (Archidendron pauciflorum) fruit peel ethanolic extract to heart histologic of rat induced by streptozotocin. Biofarmasi J Nat Prod Biochem 16: 59-63. Indonesia is ranked 7th out of 10 countries with the highest diabetic patients in the world. Diabetes mellitus is a disease that can cause heart disorders and adults who suffer from DM are four times more likely to develop heart disease. Jengkol fruit peel has been used traditionally as a drug for diabetes mellitus. The aim of this research was to know the effect of frui

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19

Shirwan, H., M. Ohanjanian, G. Burcham, L. Makowka, and D. V. Cramer. "Structure and diversity of rat T cell receptor alpha-chain genes." Journal of Immunology 150, no. 6 (1993): 2295–304. http://dx.doi.org/10.4049/jimmunol.150.6.2295.

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Abstract We have sequenced 22 TCR-alpha clones isolated from two cDNA libraries derived from rat thymocytes and heart allograft-infiltrating lymphocytes. Sixteen different V alpha and 17 J alpha genes were characterized in these clones. The V alpha genes could be divided into nine subfamilies, each containing from one to three members. Nucleotide sequence comparisons to mouse alpha genes revealed the existence of mouse homologues for all the J alpha s and 8 of 9 V alpha subfamilies. One of the rat V alpha subfamilies appeared to have no known mouse counterpart. Southern blot analysis of germ-l

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20

Kintsurashvili, Ekaterina, Arvi Duka, Ivana Ignjacev, Gregory Pattakos, Irene Gavras, and Haralambos Gavras. "Age-related changes of bradykinin B1 and B2 receptors in rat heart." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 1 (2005): H202—H205. http://dx.doi.org/10.1152/ajpheart.01287.2004.

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Aging is a major risk factor for the development of vascular diseases, such as hypertension and atherosclerosis, that leads to end organ damage and especially heart failure. Bradykinin has been demonstrated to have a cardioprotective role by affecting metabolic processes and tissue perfusion under conditions of myocardial ischemia. Its actions are exerted via the bradykinin B1- and B2-type receptors (B1Rs and B2Rs), but the functional status of these receptors during the aging process is poorly understood. This study aims to investigate whether changes in B1R and B2R gene and protein expressio

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21

Rossi, Stefano, Silvana Baruffi, Andrea Bertuzzi, et al. "Ventricular activation is impaired in aged rat hearts." American Journal of Physiology-Heart and Circulatory Physiology 295, no. 6 (2008): H2336—H2347. http://dx.doi.org/10.1152/ajpheart.00517.2008.

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Ventricular arrhythmias are frequently observed in the elderly population secondary to alterations of electrophysiological properties that occur with the normal aging process of the heart. However, the underlying mechanisms remain poorly understood. The aim of the present study was to determine specific age-related changes in electrophysiological properties and myocardial structure in the ventricles that can be related to a structural-functional arrhythmogenic substrate. Multiple unipolar electrograms were recorded in vivo on the anterior ventricular surface of four control and seven aged rats

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22

Pham, Toan, Denis Loiselle, Amelia Power, and Anthony J. R. Hickey. "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart." American Journal of Physiology-Cell Physiology 307, no. 6 (2014): C499—C507. http://dx.doi.org/10.1152/ajpcell.00006.2014.

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As ∼80% of diabetic patients die from heart failure, an understanding of diabetic cardiomyopathy is crucial. Mitochondria occupy 35–40% of the mammalian cardiomyocyte volume and supply 95% of the heart's ATP, and diabetic heart mitochondria show impaired structure, arrangement, and function. We predict that bioenergetic inefficiencies are present in diabetic heart mitochondria; therefore, we explored mitochondrial proton and electron handling by linking oxygen flux to steady-state ATP synthesis, reactive oxygen species (ROS) production, and mitochondrial membrane potential (ΔΨ) within rat hear

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23

Hardjana, Tri, Kartika Ratna Pertiwi, and Tutik Rahayu. "POTENSI BUAH SALAK (Salacca edulis, R.) SEBAGAI SUPLEMEN HIPOLIPIDEMIK DITINJAU DARI GAMBARAN HISTOPATOLOGI JANTUNG DAN HEPAR MENCIT YANG DIBERI DIET RENDAH LEMAK." Jurnal Sains Dasar 5, no. 2 (2016): 94. http://dx.doi.org/10.21831/jsd.v5i1.12672.

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Penelitian ini bertujuan mengetahui struktur histopatologi jantung mencit yang diberi sari buah salak (Salacca edulis, R) dan diet lemak hewani dan untuk mengetahui struktur histopatologi hati mencit yang diberi sari buah salak (Salacca edulis, R) dan diet lemak hewani. Penelitian ini mengguanakan metode penelitian eksperimen dengan tujuan untuk mengukur respon yang muncul dari suatu obyek sebagai akibat adanya perubahan suatu faktor yang mengenainya. Tempat penelitian dilakukan di Animal House Universitas Negeri Yogyakarta dan pengamatan preparat dilakukan di laboratorium Zoologi Fakultas MIP

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Fusi, Luca, Yanhong Wang, So-Jin Park-Holohan, et al. "Calcium Dependence of Myosin Filament Structure in Demembranated Trabeculae from Rat Heart." Biophysical Journal 120, no. 3 (2021): 252a. http://dx.doi.org/10.1016/j.bpj.2020.11.1634.

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25

Langer, G. A., J. S. Frank, T. L. Rich, and F. B. Orner. "Calcium exchange, structure, and function in cultured adult myocardial cells." American Journal of Physiology-Heart and Circulatory Physiology 252, no. 2 (1987): H314—H324. http://dx.doi.org/10.1152/ajpheart.1987.252.2.h314.

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Cells digested from adult rat heart and cultured for 14 days demonstrate all the structural elements, in mature form, associated with the process of excitation-contraction (EC) coupling. The transverase tubular (TT) system is well developed with an extensive junctional sarcoplasmic reticulum (JSR). In nonphosphate-containing buffer contraction of the cells is lost as rapidly as zero extracellular Ca concentration ([Ca]o) solution is applied (less than 10 s) and a negative contraction staircase is produced on increase of stimulation frequency. Structurally and functionally the cells have the ch

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26

Lecarpentier, Yves, Olivier Schussler, Victor Claes, Jean-Louis Hébert, Xénophon Krokidis, and Alexandre Vallée. "Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure." PLOS ONE 19, no. 3 (2024): e0298979. http://dx.doi.org/10.1371/journal.pone.0298979.

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Thermodynamic consequences of a three-hour long anoxia were investigated on the isolated mammalian rat myocardium. The anoxic heart operated in a far-from-equilibrium manner as attested by the non-linearity between the thermodynamic force and the thermodynamic flow. When subjected to slight fluctuations due to anoxia, the open far-from-equilibrium cardiac system presented a thermodynamic bifurcation at ~ 60 minutes of anoxia. The bifurcation was characterized by a sudden change of direction in the bifurcation diagram of a one-dimensional nonlinear differential equation with one parameter and o

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Moorman, J. R., Z. Zhou, G. E. Kirsch, et al. "Expression of single calcium channels in Xenopus oocytes after injection of mRNA from rat heart." American Journal of Physiology-Heart and Circulatory Physiology 253, no. 4 (1987): H985—H991. http://dx.doi.org/10.1152/ajpheart.1987.253.4.h985.

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Oocytes of Xenopus laevis, after microinjection with mRNA from rat heart, display typical high-threshold calcium (Ca) whole cell currents. To prepare to study structure-function relationships of the cardiac Ca channel molecule, we examined the fidelity of expression of biophysical and pharmacological properties at the molecular level. Cell-attached gigaseal recordings in five K-depolarized oocytes injected with adult rat heart mRNA showed single channel Ba currents with mean amplitude 1.3-1.5 pA at 0 mV, slope conductance 18-25 pS, and extrapolated reversal potential 57-68 mV. Openings were pr

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28

Korecky, Borivoj, and Mary Masika. "Use of a Heterotopic Cardiac Isotransplant for Pharmacological and Toxicological Studies*." Toxicologic Pathology 18, no. 4a (1990): 541–46. http://dx.doi.org/10.1177/019262339001804a03.

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The heterotopically transplanted rat heart provides a unique model for examination of the direct humoral effects on the myocardium since the transplanted heart is exposed to the same hormonal milieu as the in situ heart but does not support the hemodynamic load. In this model, the heart of an inbred rat is transplanted into the abdomen of a recipient of the same inbred strain by attaching the stumps of aorta and pulmonary artery end to side to the abdominal aorta and inferior vena cava of the recipient. The transplanted heart is perfused by the recipients’ blood through the coronary vessels. I

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Tverdokhlib, I. V., and D. G. Marchenko. "ULTRASTRUCTURAL FEATURES OF CARDIOMYOCYTE CONTRACTILE APPARATUS IN RAT OFFSPRING HEARTS FOLLOWING MATERNAL CHRONIC ALCOHOL INTOXICATION." Medical and Ecological Problems 28, no. 1 (2024): 34–40. http://dx.doi.org/10.31718/mep.2024.28.1.05.

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Background. The mechanisms underlying the development of the heart contractile apparatus and the distribution of myofibrils in cardiomyocytes following intrauterine ethanol intoxication continue to be a topic of significant debate. The aim of this paper is to determine the dynamics of postnatal changes in the ultrastructure of ventricular contractile cardiomyocytes in the rat heart after chronic alcoholization of the maternal organism. Methods. The study focused on the hearts of rat offspring from birth to adulthood. Transmission electron microscopy was utilized to examine the ultrastructure o

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Gutiérrez-Calabrés, Elena, Adriana Ortega-Hernández, Javier Modrego, et al. "Gut Microbiota Profile Identifies Transition From Compensated Cardiac Hypertrophy to Heart Failure in Hypertensive Rats." Hypertension 76, no. 5 (2020): 1545–54. http://dx.doi.org/10.1161/hypertensionaha.120.15123.

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Microcirculatory alterations displayed by patients with heart failure (HF) induce structural and functional intestinal changes that may affect normal gut microbial community. At the same time, gut microbiota can influence pathological mechanisms implicated in HF progression. However, it is unknown whether gut microbiota dysbiosis can precede the development of cardiac alterations in HF or it is only a mere consequence. Our aim was to investigate the potential relationship between gut microbiota composition and HF development by comparing spontaneously hypertensive heart failure and spontaneous

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Almamori, Sajad Abbas Fhadil. "Effect of Hypervitaminosis D on the Histological Structure of Heart in Albino Rat." Wasit Journal for Pure sciences 4, no. 1 (2025): 214–21. https://doi.org/10.31185/wjps.617.

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Macchi, Emilio, Massimo Cavalieri, Donatella Stilli, et al. "High-density epicardial mapping during current injection and ventricular activation in rat hearts." American Journal of Physiology-Heart and Circulatory Physiology 275, no. 5 (1998): H1886—H1897. http://dx.doi.org/10.1152/ajpheart.1998.275.5.h1886.

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The purpose of this study is to report new methods for manufacturing precision electrode arrays for recording high-resolution potential distributions from epicardial surfaces of small-animal hearts. Electrode arrays of 64 leads (8 × 8) and 121 leads (11 × 11) were constructed with a tulle substrate to which insulated, fine silver wires (60-μm diameter) were attached by knots at mesh node intervals of 540 × 720 μm. Insulation was removed at the tips of the knots. Potential distributions and waveforms were recorded from saline solutions and rat heart epicardium during ventricular paced beats and

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Sakurai, Kenzo, Yuko Takeba, Yosuke Osada, et al. "Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses." International Journal of Molecular Sciences 23, no. 17 (2022): 10186. http://dx.doi.org/10.3390/ijms231710186.

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Although the rate of preterm birth has increased in recent decades, a number of preterm infants have escaped death due to improvements in perinatal and neonatal care. Antenatal glucocorticoid (GC) therapy has significantly contributed to progression in lung maturation; however, its potential effects on other organs remain controversial. Furthermore, the effects of antenatal GC therapy on the fetal heart show both pros and cons. Translational research in animal models indicates that constant fetal exposure to antenatal GC administration is sufficient for lung maturation. We have established a p

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Chen, Jiqiu, Elisa Yaniz-Galende, Heather J. Kagan, et al. "Abnormalities of capillary microarchitecture in a rat model of coronary ischemic congestive heart failure." American Journal of Physiology-Heart and Circulatory Physiology 308, no. 8 (2015): H830—H840. http://dx.doi.org/10.1152/ajpheart.00583.2014.

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The aim of the present study is to explore the role of capillary disorder in coronary ischemic congestive heart failure (CHF). CHF was induced in rats by aortic banding plus ischemia-reperfusion followed by aortic debanding. Coronary arteries were perfused with plastic polymer containing fluorescent dye. Multiple fluorescent images of casted heart sections and scanning electric microscope of coronary vessels were obtained to characterize changes in the heart. Cardiac function was assessed by echocardiography and in vivo hemodynamics. Stenosis was found in all levels of the coronary arteries in

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Gesmundo, Iacopo, Michele Miragoli, Pierluigi Carullo, et al. "Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure." Proceedings of the National Academy of Sciences 114, no. 45 (2017): 12033–38. http://dx.doi.org/10.1073/pnas.1712612114.

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It has been shown that growth hormone-releasing hormone (GHRH) reduces cardiomyocyte (CM) apoptosis, prevents ischemia/reperfusion injury, and improves cardiac function in ischemic rat hearts. However, it is still not known whether GHRH would be beneficial for life-threatening pathological conditions, like cardiac hypertrophy and heart failure (HF). Thus, we tested the myocardial therapeutic potential of GHRH stimulation in vitro and in vivo, using GHRH or its agonistic analog MR-409. We show that in vitro, GHRH(1-44)NH2 attenuates phenylephrine-induced hypertrophy in H9c2 cardiac cells, adult

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Shirinov M.M., Teshaev Sh.J., Eshpulatov E.Y. "SIMILARITIES BETWEEN MORPHOLOGICAL INDICATORS OF THE STOMACH OF HUMANS AND WHITE-BREEDLESS RATS." European Journal of Medical Genetics and Clinical Biology 1, no. 1 (2023): 169–71. http://dx.doi.org/10.61796/jmgcb.v1i1.274.

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. Information about the anatomy of the stomach of white-breedless rats is very rare in the scientific literature. The shape, structure, and topography of rat stomachs are significantly different from those of vertebrates, but the same sections as shark stomachs can be found in them. This structure of white rat stomach sections characterizes the sac-like formation of the digestive tract. In the anterior part of the abdominal cavity of rats, on the left side of the midline, there is a hole for the heart between the esophagus and the line of the lesser curvature of the stomach. The liver is locat

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37

Zahler, R., W. Sun, T. Ardito, and M. Kashgarian. "Na-K-ATPase alpha-isoform expression in heart and vascular endothelia: cellular and developmental regulation." American Journal of Physiology-Cell Physiology 270, no. 1 (1996): C361—C371. http://dx.doi.org/10.1152/ajpcell.1996.270.1.c361.

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The Na pump (Na-K-ATPase) is important for regulation of membrane potential and transport in smooth muscle and heart. The alpha (catalytic)-subunit of this pump has three isoforms: alpha 1 is ubiquitous, but alpha 2 and alpha 3 are mainly localized to excitable tissue. Physiological differences between isoforms are not completely understood, but alpha 3 pumps appear to have a lower affinity for intracellular Na and a higher ouabain affinity than alpha 1 pumps. The alpha 2-and alpha 3-isoform mRNAs are expressed at high levels in the normal adult rat cardiac conduction system. Although alpha 1

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Shirwan, H., L. Barwari, I. Fuss, L. Makowka, and D. V. Cramer. "Structure and repertoire usage of rat TCR alpha-chain genes in T cells infiltrating heart allografts." Journal of Immunology 154, no. 4 (1995): 1964–72. http://dx.doi.org/10.4049/jimmunol.154.4.1964.

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Abstract We have studied the structure and diversity of TCR alpha-chain genes used by graft-infiltrating lymphocytes (GIL) in the ACI-to-LEW rat cardiac allograft model. We previously reported the structure of 16 different V alpha and 17 different J alpha genes isolated in two different cDNA libraries established from LEW thymocytes and GIL. In this report, we obtained new sequence information for 17 additional V alpha and J alpha genes from the GIL cDNA library. This study completes our characterization of 33 different V alpha and 23 different J alpha genes in rats. The V alpha genes are clas

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Andelova, Katarina, Matus Sykora, Veronika Farkasova, et al. "Acclimation of Hairless Spontaneously Hypertensive Rat to Ambient Temperature Attenuates Hypertension-Induced Pro-Arrhythmic Downregulation of Cx43 in the Left Heart Ventricle of Males." Biomolecules 14, no. 12 (2024): 1509. http://dx.doi.org/10.3390/biom14121509.

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Objectives: Due to poor treatment adherence and lifestyle-based interventions, chronic hypertension is a dominant risk factor predisposing individuals to heart failure and malignant arrhythmias. We investigated the impact of the postnatal acclimation of hairless SHR to ambient temperature that is, for them, below thermoneutrality, on the electrical coupling protein connexin-43 (Cx43) and pro-fibrotic markers in both heart ventricles of male and female hairless SHR rats compared to the wild SHR. Methods: Some 6-month-acclimated male and female hairless SHR as well as age- and sex-matched wild S

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Hutchinson, W. L., P. G. Morris, and J. Mowbray. "The molecular structure of a rapidly formed oligomeric adenosine tetraphosphate derivative from rat heart." Biochemical Journal 234, no. 3 (1986): 623–27. http://dx.doi.org/10.1042/bj2340623.

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The inability to account for large systematic variations with time in soluble adenine nucleotides in perfused rat hearts [Bates, Perrett & Mowbray (1978) Biochem. J. 176, 485-493; Mowbray, Bates & Perrett (1981) FEBS Lett. 131, 55-59; Mowbray, Perrett & Bates (1984) Int. J. Biochem. 16, 889-894] led us to show that the soluble nucleotides are in rapid equilibrium with some hitherto unrecognized trichloroacetic acid/methanol-precipitable highly phosphorylated heteropolymeric form [Mowbray, Hutchinson, Tibbs & Morris (1984) Biochem. J. 223, 627-632]. Selective digestion coupled t

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Dos Santos, Pierre, Alicia J. Kowaltowski, Muriel N. Laclau, et al. "Mechanisms by which opening the mitochondrial ATP- sensitive K+ channel protects the ischemic heart." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 1 (2002): H284—H295. http://dx.doi.org/10.1152/ajpheart.00034.2002.

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Diazoxide opening of the mitochondrial ATP-sensitive K+ (mitoKATP) channel protects the heart against ischemia-reperfusion injury by unknown mechanisms. We investigated the mechanisms by which mitoKATP channel opening may act as an end effector of cardioprotection in the perfused rat heart model, in permeabilized fibers, and in rat heart mitochondria. We show that diazoxide pretreatment preserves the normal low outer membrane permeability to nucleotides and cytochrome c and that these beneficial effects are abolished by the mitoKATP channel inhibitor 5-hydroxydecanoate. We hypothesize that an

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Borges, Júlio César, JoséAntônio Silva, Maria Aparecida Gomes, et al. "Tonin in rat heart with experimental hypertrophy." American Journal of Physiology-Heart and Circulatory Physiology 284, no. 6 (2003): H2263—H2268. http://dx.doi.org/10.1152/ajpheart.00416.2002.

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The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg · kg−1 · day−1sc). For untreated animals, the levels of tonin-specific activity in the atrium were 2.6- and 5.5-fold higher than those of the left and right ventricle, respectively. After treatment, the levels of tonin-specific activity increased twofold in the atrium but did not change in the ventric

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Minamikawa, T., S. H. Cody, and D. A. Williams. "In situ visualization of spontaneous calcium waves within perfused whole rat heart by confocal imaging." American Journal of Physiology-Heart and Circulatory Physiology 272, no. 1 (1997): H236—H243. http://dx.doi.org/10.1152/ajpheart.1997.272.1.h236.

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We describe the first direct visualization of Ca2+ oscillations in the perfused whole rat heart. Dye loading at a low temperature and enhanced optical-section techniques of confocal microscopy by elimination of the refractive index mismatch with use of saline-immersible objective lens enabled us to image multiple Ca2+ waves in the subepicardial myocardium of the fluo 3-loaded heart. These Ca2+ waves were sporadically seen even with a physiological extracellular Ca2+ perfusion in either a paced or an arrested heart and propagated beyond cellular boundaries within the three-dimensional structure

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Huang, Shiang-Suo, Sheau-Farn Yeh, and Chuang-Ye Hong. "Effect of Anthraquinone Derivatives on Lipid Peroxidation in Rat Heart Mitochondria: Structure-Activity Relationship." Journal of Natural Products 58, no. 9 (1995): 1365–71. http://dx.doi.org/10.1021/np50123a005.

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Robert, V., S. Ayoub, and G. Berson. "Effects of hydroxyl radicals on ATPase and protein structure of myofibrils from rat heart." American Journal of Physiology-Heart and Circulatory Physiology 261, no. 6 (1991): H1785—H1790. http://dx.doi.org/10.1152/ajpheart.1991.261.6.h1785.

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Free oxygenated radicals frequently are involved in cardiac arrhythmias and contractility disorders during postischemic reperfusion. The aim of this study was to determine the effects of hydroxyl radicals (.OH) in vitro on myofibrillar Ca-adenosinetriphosphatase (ATPase), on the redox state of thiol groups and the electrophoretic pattern of myofibrillar proteins from rat heart. Myofibrils were treated up to 60 min by .OH generated with 0.3 mM H2O2 and 0.1 mM Fe2+. After a 60-min treatment with .OH, the measurement of thiol groups failed to show any oxidation. On the contrary, ATPase activity a

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Okada, Hitoshi, Kuniaki Ishii, Kazuo Nunoki, and Norio Taira. "Structure and functional expression of the MDCK type chloride channel cloned from rat heart." Japanese Journal of Pharmacology 64 (1994): 348. http://dx.doi.org/10.1016/s0021-5198(19)51026-5.

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Panjehshahin, M. R., and F. Dehghani. "The effect of glycerol on microscopic structure of heart: An experimental model in rat." Toxicology Letters 164 (September 2006): S307. http://dx.doi.org/10.1016/j.toxlet.2006.07.297.

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Galron, Ronit, Yoel Kloog, Avner Bdolah, and Mordechai Sokolovsky. "Functional endothelin/sarafotoxin receptors in rat heart myocytes: Structure-activity relationships and receptor subtypes." Biochemical and Biophysical Research Communications 163, no. 2 (1989): 936–43. http://dx.doi.org/10.1016/0006-291x(89)92312-7.

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Ferrario, Carlos M., Jessica VonCannon, Yan Jiao, et al. "Cardiac angiotensin-(1–12) expression and systemic hypertension in rats expressing the human angiotensinogen gene." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 8 (2016): H995—H1002. http://dx.doi.org/10.1152/ajpheart.00833.2015.

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Angiotensin-(1–12) [ANG-(1–12)] is processed into ANG II by chymase in rodent and human heart tissue. Differences in the amino acid sequence of rat and human ANG-(1–12) render the human angiotensinogen (hAGT) protein refractory to cleavage by renin. We used transgenic rats harboring the hAGT gene [TGR(hAGT)L1623] to assess the non-renin-dependent effects of increased hAGT expression on heart function and arterial pressure. Compared with Sprague-Dawley (SD) control rats ( n = 11), male homozygous TGR(hAGT)L1623 ( n = 9) demonstrated sustained daytime and nighttime hypertension associated with n

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Zimmer, Thomas, Christian Bollensdorff, Volker Haufe, Eckhard Birch-Hirschfeld, and Klaus Benndorf. "Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 3 (2002): H1007—H1017. http://dx.doi.org/10.1152/ajpheart.00644.2001.

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We isolated two full-length cDNA clones from the adult murine heart that encode two different voltage-gated Na+ channels: mH1 and mH2. Sequence comparisons indicated that mH1 is highly homologous to rat SCN5A, whereas mH2 is highly homologous to SCN4A, expressed in rat skeletal muscle. Electrophysiological properties of mH1 channels strongly resembled the tetrodotoxin (TTX)-resistant Na+ current of mouse ventricular cells, whereas mH2 channels activated at more positive potentials and were highly sensitive to TTX [50% inhibitory constant (IC50) = 11 nM]. We found that mH2 is not expressed in c

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