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Dissertations / Theses on the topic 'Succinimidyl'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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1

Husain, Philip Anwar. "Investigative enzymology of selected monooxygenases and development of (S)-N-Succinimidyl-a-Methoxyphenylacetate as a novel tool for assignment of absolute configuration." Diss., Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/27579.

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2

Hoppmann, Susan. "18F-markierte S100-Proteine als potentielle Radioliganden für die funktionelle Charakterisierung des Rezeptors für advanced glycation endproducts (RAGE) in vitro und in vivo." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-24725.

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Die Interaktion von S100-Proteinen mit dem Rezeptor für advanced glycation endproducts (RAGE) wird als hoch relevant bei der Entstehung, Manifestation und Progression verschiedener entzündlicher Erkrankungen sowie bei der Tumorigenese gewertet. Das tiefergehende Verständnis der Interaktion von S100-Proteinen mit RAGE in vivo stellt eine wissenschaftliche Herausforderung dar und ist ein Ansatz für therapeutische Interventionen. Darüber hinaus stellen Untersuchungen zum Metabolismus von extrazellulär zirkulierenden S100-Proteinen in vivo einen vielversprechenden Forschungsansatz zur Analyse von
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3

Cunha, Saulo Marques da. "Síntese de análogos succinimidas da (-)-julocrotina." reponame:Repositório Institucional da UnB, 2013. http://repositorio.unb.br/handle/10482/15084.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Química, Programa de Pós-Graduação em Química, 2013.<br>Submitted by Alaíde Gonçalves dos Santos (alaide@unb.br) on 2013-11-13T14:03:47Z No. of bitstreams: 1 2013_SauloMarquesdaCunha.pdf: 5424545 bytes, checksum: 70f8ae81d705e8d41b709943a346aa31 (MD5)<br>Approved for entry into archive by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br) on 2014-02-03T12:20:23Z (GMT) No. of bitstreams: 1 2013_SauloMarquesdaCunha.pdf: 5424545 bytes, checksum: 70f8ae81d705e8d41b709943a346aa31 (MD5)<br>Made available in DSpace on 2014-02-03T12:20:2
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4

Wei, Lai. "Asymmetric organocatalysis in the Michael reaction of cyclic α-alkyl ketones : enantioselective synthesis of suberosanes and succinimides". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS325.

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La découverte des activités cytotoxiques impressionnantes des subérosanes, des sesquiterpènes d’origine marine isolées dès 1996 de la gorgone Subergorgia suberosa, ainsi que leurs structures tricycliques complexes possédant jusqu’à cinq centre stéréogènes contigus dont un centre quaternaire central, ont fait de ces molécules des cibles de choix tant pour les acteurs de la chimie médicinale que pour ceux travaillant dans le domaine de la synthèse totale. Enfin, une molécule d’origine synthétique « simplifiée » de cette famille, la nor-subérosénone, a également montré des activités cytotoxiques
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5

Lenz, Stefan [Verfasser], and Armin [Akademischer Betreuer] Geyer. "Succinimid-Thioether in der Peptidligation - Methodenentwicklung und Strukturaufklärung / Stefan Lenz ; Betreuer: Armin Geyer." Marburg : Philipps-Universität Marburg, 2018. http://d-nb.info/1164156217/34.

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6

Sutton, Michael Robert. "Investigation of succinimide dispersants and their interactions using reduced total oil volume lubricant degradation." Thesis, De Montfort University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391994.

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7

Wong, Shi Quan. "Using Caenorhabditis elegans to identify succinimide-based neuroprotective compounds and their mechanisms of action." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3017944/.

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8

Zhang, Jie. "Influence of succinimide dispersants on film formation, friction and antiwear properties of zinc dialkyl dithiophosphate." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9196.

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ZDDP (zinc dialkyldithiophosphate) is arguably the most successful antiwear additive ever employed in crankcase engine lubricants. It was originally used as an antioxidant and shortly afterwards recognized for its antiwear and extreme pressure properties. Unfortunately, another critical additive polyisobutylsuccinimide-polyamine (PIBSA-PAM), which is used as a dispersant in engine oils, is known to be antagonistic to ZDDP in terms of film formation, friction and wear. The mechanisms of this antagonism have been widely studied, but they are still not well understood. Furthermore, in order to pr
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9

Silva, Fabio Machado da. "Reações entre ácidos β-cianocarboxílicos e nitrogênios nucleofílicos: uma eficiente estratégia para a síntese de succinimidas, pirrolidinonas e tetrazóis". Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4204.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This work presents the synthesis of 41 succinimides, 24 pyrrolidinones and 8 tetrazoles, all presenting unprecedented chemical structure, except for the succinimide 3-ethoxy-1-methylpyrrolidine-2,5-dione. These compounds were synthesized by cyclization reactions of β-cyanocarboxylic acids of general formula HO2CCH(R1)CH(OR)CN, where R/R1 = Et/H (9), -(CH2)2- (10), -(CH2)3- (11), Et/Me (12), i-Pr/H (13), s-Bu/H (14), i-Pr/Me (15), s-Bu/Me (16), with amine derivatives or sodium azide. Initially NR2-substituted 3-ethoxypyrrolidine
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10

Flores, Ferrándiz Jesús. "Chiral Aminocarbamates Derived from trans-Cyclohexane-1,2-Diamines as Organocatalysts in Conjugate Addition Reactions." Doctoral thesis, Universidad de Alicante, 2017. http://hdl.handle.net/10045/73589.

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The thesis has been divided in two chapters: Chapter I describes the preparation of primary-amine monocarbamates from enantiopure trans-cyclohexane-1,2-diamines and their use as chiral organocatalysts in the enantioselective Michael addition reaction of aldehydes and ketones to maleimides, to synthesize enantiomerically enriched substituted succinimides. In the conjugate addition reaction of aldehydes to maleimides in conventional volatile organic solvents, it has been found that these organocatalysts are able to generate both enantiomers of the corresponding succinimide using only one enantio
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11

Mamouni, Aïcha. "Synthèse et réactivité de pyrrolo(ou pyrido)thiéno[2]azépine diversement fonctionnalisées." Le Havre, 1996. http://www.theses.fr/1996LEHA0010.

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Lors de ce travail, nous avons synthétisé des N-thiénylméthylsuccinimides (ou tétraméthylsuccinimides) dont nous avons étudié la réactivité. Leur réduction conduit aux hydroxylactames qui donnent deux types de réaction selon que le milieu acide est ou basique. Dans le premier cas, nous assistons à la formation d'ions N-acyliminiums ou d'énamidones (formés par réarrangement de Meyer-Schuster). Dans le second cas, nous avons formation du carbonyle masqué qui donne lieu à des réactions de type Wittig. Les produits précédents ont été utilisés dans diverses réactions de cyclisation telles que : 1)
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12

Matte, Denise. "Etude cinétique de la N-chloration en phase aqueuse de dérivés azotés (triazine 1-3-5 trione, diméthylamine, diéthylamine, N-méthylacétamide et succinimide)." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37599704j.

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13

wang, xin. "PEPTIDE LINKED POLYMERS FOR CADIOVASCULAR APPLICATIONS." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1340826344.

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14

Barman, Gopa. "Synthetic studies on N - Aryl Y - Lactam & N - Aryl Y - Thio - Lactam : chemoselective Transformation to N-Aryl-Pyrrolidine, N-Aryl Succinimide and Other Bioactive Compounds." Thesis, University of North Bengal, 2009. http://hdl.handle.net/123456789/1379.

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15

Matviiuk, Tetiana. "Conception, synthèse et activités biologiques de 1,3-pyrrolidines-2,5-diones disubstitués comme agents antituberculeux potentiels." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2650/.

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La thèse est consacrée à la synthèse de pyrrolidine- 2,5-diones 1,3- disubstituées et l'évaluation de leur activité inhibitrice contre la protéine de InhA et Mycobacterium tuberculosis. En particulier, de nouvelles conditions catalytiques pour la réaction de Michael ont été trouvées. Des acides de Lewis (par exemple: AlCl3, ZnCl2 et LiClO4) ont été développés en tant que catalyseurs efficaces pour la série d'addition conjuguée de nucléophiles hétérocycles à maléimides. De nouvelles conditions ont permis la synthèse efficace de composés pyrrolidine-2,5-diones substituées par des hétérocycles en
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16

Song, Tao. "Alkylation allylique asymétrique pallado-catalysée : contrôle de centres quaternaires au sein d'hétérocycles azotés." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLET012.

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Le développement d’outils synthétiques permettant le contrôle de centres stéréogènes quaternaires reste un défi important en synthèse organique. Dans ce contexte, l’alkylation allylique asymétrique pallado-catalysée est apparue comme une méthode particulièrement efficace. Le premier chapitre de cette thèse est consacré à l’application de cette réaction d’alkylation allylique asymétrique à des dérivés de type succinimides. Cette méthode, convergente, nous a permis d’accéder à un grand nombre de composés de type succinimide comportant un centre stéréogène quaternaire en position alpha avec de bo
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17

Höglund, Johanna. "On the use of ⁷⁶Br-labelled monoclonal antibodies for PET : preclinical evaluation of halogenated antibodies for diagnosis and treatment of cancer /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5258-2/zabstract.

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18

Dandekar, Sushama A. "Studies of intramolecular SRN1 reactions of carbanions derived from 2-(o-halobenzyl)amides and 3-(o-halobenzyl)imides: application to the synthesis of succinimido[3,4-b]indane, a potential anticonvulsant." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/40096.

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19

Jelena, Ćurčić. "In silico određivanje fizičko-hemijskih, farmakokinetskih i toksikoloških parametara i in vitro ispitivanje antiproliferativne aktivnosti novosintetisanih derivata N-sukcinimida." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=113945&source=NDLTD&language=en.

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Sukcinimidi su jedinjenja koja pokazuju vi&scaron;estruke farmakolo&scaron;ke efekte uključujući i antiproliferativnu aktivnost, zahvaljujući prisustvu farmakofore sa dva hidrofobna regiona i dva regiona bogata elektronima. Savremeni dizajn lekova ima za cilj da se modifikacijama u strukturi (promena vrste, položaja i orijentacije supstituenata) i in silico računarskim metodama predvide i optimizuju farmakokinetske osobine i bezbednosni profil kandidata za lek. U ranoj fazi razvoja lekova se koriste postojeće baze podataka o molekulskim, farmakokinetskim i toksikolo&scaron;kim parametrima već
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20

Wang, Yulin. "Synthesis and Characterization of Ethylene Carbonate Modified Polyisobutylene Succinimide Dispersants." Thesis, 2010. http://hdl.handle.net/10012/5202.

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Succinimide-based dispersants are the most commonly used dispersants in the oil industry. They are used in engine oil to prevent the aggregation of carbon-rich particles generated during engine operation, and consequently reduce the production of sludge and the emission of fine particles into the air that cause air pollution. This project aims at studying the efficiency of a series of non-ionic dispersants at stabilizing carbon-rich particles in an apolar solvent. The dispersants are composed of two polyisobutylene apolar chains and a polyamine core that was modified by reacting the dispersant
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21

Chang, Chao-Wei, and 張朝為. "The novel formulation of poly(methacryloxy succinimide) with N-(4-aminobutyl)maleimide for chemotherapy application." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/2c3865.

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碩士<br>國立嘉義大學<br>生化科技研究所<br>97<br>Polymers with intrinsic antitumour properties, soluble polymer conjugates, and micelles and polymer-protein adducts have been known for many years. These compounds are considered as new chemical entities. Conjugation of drugs to these polymeric carriers can restrict cellular uptake of the drug to the endocytic route and significantly change the biodistribution of conjugated drug. The polymer drug conjugate consists of a water soluble polymer as carrier, biodegradable linkers to facilitate controlled release of drug at the tumor site and non-biodegradable linker
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22

Gan, Shao MIng. "Marquage fluorescent des protéines pour étudier les enzymes protéolytiques solubles et immobilisées par la cartographie peptidique électrophorétique." Thèse, 2010. http://hdl.handle.net/1866/4510.

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La cartographie peptidique est une méthode qui permet entre autre d’identifier les modifications post-traductionnelles des protéines. Elle comprend trois étapes : 1) la protéolyse enzymatique, 2) la séparation par électrophorèse capillaire (CE) ou chromatographie en phase liquide à haute performance (HPLC) des fragments peptidiques et 3) l’identification de ces derniers. Cette dernière étape peut se faire par des méthodes photométriques ou par spectrométrie de masse (MS). Au cours de la dernière décennie, les enzymes protéolytiques immobilisées ont acquis une grande popularité parce qu’elles p
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23

Chen, Chih-ching, and 陳志清. "1. A New Approach to 3,4-Disubstituted Succinimides and Its Applications in Natural Product Synthesis2. A New Approach to (E)-3-Substituted-N-alkyl Acrylamides and Its Applications." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/4t2n5c.

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博士<br>國立中山大學<br>化學系研究所<br>96<br>1. We have explored a formal [3+2] strategy that is synthetically useful for constructing 3,4-disubstituted succinimides with ethyl bromoacetate derivatives or methyl glyoxylate in one step. 2. We reported a new approach to (E)-β-aryl-α,β-unsaturated amides. Instead of using aldehydes, phosphorus, silicon containing compounds and metal catalysts for the synthesis of double bonds, α-sulfonyl acetamide and various benzyl bromides were used as starting materials
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