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1

Leonard, Nicholas M., and Jarmila Brunckova. "In Situ Formation ofN-Trifluoroacetoxy Succinimide (TFA-NHS): One-Pot Formation of Succinimidyl Esters,N-Trifluoroacetyl Amino Acid Succinimidyl Esters, andN-Maleoyl Amino Acid Succinimidyl Esters." Journal of Organic Chemistry 76, no. 21 (2011): 9169–74. http://dx.doi.org/10.1021/jo201686e.

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2

Merényi, Gábor, Johan Lind, Lennart Eberson, et al. "The Return of the Succinimidyl Radical." Acta Chemica Scandinavica 52 (1998): 62–66. http://dx.doi.org/10.3891/acta.chem.scand.52-0062.

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3

Mamat, Constantin, Daniel Holger Weiß, and Martin Köckerling. "X-ray Structures of Succinimidyl Halobenzoates." Crystals 7, no. 3 (2017): 90. http://dx.doi.org/10.3390/cryst7030090.

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4

Mujumdar, Swati R., Ratnakar B. Mujumdar, Charsetta M. Grant, and Alan S. Waggoner. "Cyanine-Labeling Reagents: Sulfobenzindocyanine Succinimidyl Esters." Bioconjugate Chemistry 7, no. 3 (1996): 356–62. http://dx.doi.org/10.1021/bc960021b.

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5

Janabi, Mustafa, Catherine M. Pollock, Ann-Marie Chacko, and Duncan H. Hunter. "Resin-supported arylstannanes as precursors for radiolabeling with iodine: benzaldehydes, benzoic acids, benzamides, and NHS esters." Canadian Journal of Chemistry 93, no. 2 (2015): 207–17. http://dx.doi.org/10.1139/cjc-2014-0265.

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A highly cross-linked polystyrene resin bearing a reactive chlorostannane moiety 1 has been used to generate a variety of arylstannane radiopharmaceutical precursors for no-carrier-added radioiodination. The resins were characterized for their solvent compatibility and sensitivity to acid cleavage. Resin-supported arylstannanes synthesized via their aryllithium analogues include 3- and 4-stannylbenzaldehydes, 3- and 4-stannylbenzoic acids, and 3- and 4-N-succinimidyl benzoates. A three-step route to the resin-supported stannylbenzoic acids 12a/b was developed through resin-supported benzaldehy
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6

MRIDULA, VERMA, and M. VERMA SHIVA. "Hydrogen Bonding and the Stereochemistry of Hydrazones and Hydrazides derived from 1,3-Dicarbonyl Compounds involving Imino Nitrogen." Journal of Indian Chemical Society Vol. 69, Sep 1992 (1992): 561–62. https://doi.org/10.5281/zenodo.6006453.

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Department of Chemistry, Banaras Hindu University, Varanasi-221 005 <em>Manuscript received 5 August 1991, revised 8 June 1992, accepted 3 July 1992</em> <em>&beta;</em>-Diketones form hydrazones with <em>N&#39; ,N&#39;</em> -diacylhydrazines and exhibit a six-membered hydrogen bonded cyclic ketiminyl system involving the imino nitrogen. <sup>1</sup>H nmr spectra of the hydrazones obtained from <em>N</em>-amino -&alpha;, &beta;- (9,10-dihydroanthracene-9,10-endo-diyl)succinimide and acetylacetone demonstrated restricted rotation about <em>N-N</em> bond and a planer hydrogen bonded cyclic syste
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7

Mujumdar, Ratnakar B., Lauren A. Ernst, Swati R. Mujumdar, Christopher J. Lewis, and Alan S. Waggoner. "Cyanine dye labeling reagents: Sulfoindocyanine succinimidyl esters." Bioconjugate Chemistry 4, no. 2 (1993): 105–11. http://dx.doi.org/10.1021/bc00020a001.

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8

Bardajee, Ghasem Rezanejade, Mitchell A. Winnik, and Alan J. Lough. "Succinimidyl 7-methoxy-2H-chromene-3-carboxylate." Acta Crystallographica Section E Structure Reports Online 63, no. 3 (2007): o1513—o1514. http://dx.doi.org/10.1107/s1600536807004175.

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In the title molecule, C15H11NO7, the dihedral angle between the coumarin unit and the succinimide unit is 72.36 (4)°. The crystal structure is stabilized by weak intermolecular C—H...O hydrogen bonds and π–π stacking interactions.
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9

van den Boom, Johannes, Marija Mamić, Daniele Baccelliere, et al. "Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors." ChemBioChem 15, no. 15 (2014): 2233–37. http://dx.doi.org/10.1002/cbic.201402108.

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10

Southwick, Philip L., Lauren A. Ernst, Erica W. Tauriello, et al. "Cyanine dye labeling reagents—carboxymethylindocyanine succinimidyl esters." Cytometry 11, no. 3 (1990): 418–30. http://dx.doi.org/10.1002/cyto.990110313.

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11

Gordeeva, Arina I., Anastasia A. Valueva, Maria O. Ershova, et al. "Mass Spectrometric Identification of BSA Covalently Captured onto a Chip for Atomic Force Microscopy." International Journal of Molecular Sciences 24, no. 10 (2023): 8999. http://dx.doi.org/10.3390/ijms24108999.

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Mass spectrometry (MS) is one of the main techniques for protein identification. Herein, MS has been employed for the identification of bovine serum albumin (BSA), which was covalently immobilized on the surface of a mica chip intended for investigation by atomic force microscopy (AFM). For the immobilization, two different types of crosslinkers have been used: 4-benzoylbenzoic acid N-succinimidyl ester (SuccBB) and dithiobis(succinimidyl propionate) (DSP). According to the data obtained by using an AFM-based molecular detector, the SuccBB crosslinker was more efficient in BSA immobilization t
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12

Parrish, Emmabeth, Katie A. Rose, Matteo Cargnello, Christopher B. Murray, Daeyeon Lee, and Russell J. Composto. "Nanoparticle diffusion during gelation of tetra poly(ethylene glycol) provides insight into nanoscale structural evolution." Soft Matter 16, no. 9 (2020): 2256–65. http://dx.doi.org/10.1039/c9sm02192b.

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Single particle tracking (SPT) of PEG grafted nanoparticles (NPs) was used to examine the gelation of tetra poly(ethylene glycol) (TPEG) succinimidyl glutarate (TPEG-SG) and amine (TPEG-A) terminated 4-armed stars.
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13

Fowler, J. F., and J. C. Edge. "Occupational airborne allergic contact dermatitis from succinimidyl carbonates." Contact Dermatitis 45, no. 1 (2001): 38. http://dx.doi.org/10.1034/j.1600-0536.2001.045001038.x.

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14

Kasai, Paul H. "Succinimidyl and phthalimidyl radicals: matrix isolation ESR study." Journal of the American Chemical Society 114, no. 8 (1992): 2875–80. http://dx.doi.org/10.1021/ja00034a018.

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15

Zaidi, S. A. A., Shahjahan, M. Sharif, and K. S. Siddiqi. "Transition Metal Complexes of 2-(N-Succinimidyl)Pyrimidine." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 23, no. 9 (1993): 1571–84. http://dx.doi.org/10.1080/15533179308016707.

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16

Liu, Ya-Ling, Pei Zou, Jun Wu, Hong-Yong Wang, and Shi-Neng Luo. "Crystal structure of N-succinimidyl-4-fluorobenzoate, C11H8FNO4." Zeitschrift für Kristallographie - New Crystal Structures 228, no. 1 (2013): 49–50. http://dx.doi.org/10.1524/ncrs.2013.0031.

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17

Kaushik, Ajeet, Pratikkumar Shah, Phani Kiran Vabbina, et al. "A label-free electrochemical immunosensor for beta-amyloid detection." Analytical Methods 8, no. 31 (2016): 6115–20. http://dx.doi.org/10.1039/c6ay01910b.

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A label-free detection of beta-amyloid (βA) proteins using an electrochemical immunosensor fabricated via immobilizing specific anti-beta-amyloid antibodies (An-βA-Abs) onto an interdigitated electrode of gold (IDE-Au) modified using a self-assembled monolayer (SAM) of dithiobis(succinimidyl propionate) [DTSP] is presented here.
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18

Poreba, M. A., C. X. Dong, S. K. Li, A. Stahl, J. H. Miner, and P. L. Brubaker. "Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells." American Journal of Physiology-Endocrinology and Metabolism 303, no. 7 (2012): E899—E907. http://dx.doi.org/10.1152/ajpendo.00116.2012.

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The antidiabetic intestinal L cell hormone glucagon-like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion and inhibits gastric emptying. GLP-1 secretion is stimulated by luminal oleic acid (OA), which crosses the cell membrane by an unknown mechanism. We hypothesized that L cell fatty acid transport proteins (FATPs) are essential for OA-induced GLP-1 release. Therefore, the murine GLUTag L cell model was used for immunoblotting, [3H]OA uptake assay, and GLP-1 secretion assay as determined by radioimmunoassay following treatment with OA ± phloretin, sulfo- N-succinimidyl oleate, o
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19

Zhang, Yu-Huang, Ming-Hua Dong, Xi-Kui Jiang, and Yuan L. Chow. "The chain carriers of intermolecular hydrogen abstraction in the photobromination with N-bromosuccinimide; modifications of the chain carriers." Canadian Journal of Chemistry 68, no. 10 (1990): 1668–75. http://dx.doi.org/10.1139/v90-260.

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The photoinitiated bromination of 1-chloropentane with N-bromosuccinimide (NBS) in the presence of Br2 is compared with that of NBS and 1,1-dichloroethene to generate the succinimidyl radical (S•) and with that of Br2 + K2CO3 to generate the bromine atom (Br•) as the chain carriers. The relative reactivities of intermolecular H-abstraction (r-values) shown by the NBS + Br2 system decrease to levels lower than those shown by either S• or Br• chain propagations at lower temperatures under appropriate conditions: these observations indicate the presence of a new chain propagating species that is
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20

Rohrer, Jurg, Jeanne Elia, and Jacob Rabenstein. "Optimization of loading conditions for a violet dye for use in cell proliferation studies (65.9)." Journal of Immunology 186, no. 1_Supplement (2011): 65.9. http://dx.doi.org/10.4049/jimmunol.186.supp.65.9.

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Abstract Fluorescein diacetate (FDA) and its derivatives, such as carboxyfluorescein succinimidyl ester (CFSE) are nonfluorescent molecules that diffuse into cells and are hydrolyzed by intracellular non-specific esterases to become fluorescent by-products. These fluorescent dye molecules accumulate only in live cells with intact cell membranes and active esterases, while dead cells remain non fluorescent. The precise kinetics of membrane transport and intracellular hydrolysis of FDA and its analogs are related to cellular functions. FDA dyes have been shown to have multiple uses which include
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21

Ledoan, Trung, Rodolphe Auger, Abdellah Benjahad, and Jean-Pierre Tenu. "High Specific Radioactivity Labeling of Oligonucleotides with3H-Succinimidyl Propionate." Nucleosides and Nucleotides 18, no. 2 (1999): 277–89. http://dx.doi.org/10.1080/15257779908043074.

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22

Mhidia, Reda, Aurélie Vallin, Nathalie Ollivier, et al. "Synthesis of Peptide−Protein Conjugates UsingN-Succinimidyl Carbamate Chemistry." Bioconjugate Chemistry 21, no. 2 (2010): 219–28. http://dx.doi.org/10.1021/bc900154r.

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23

Wang, Xiao-Qi, Xiu-Mei Duan, Li-Hua Liu, Yan-Qiu Fang, and Yan Tan. "Carboxyfluorescein Diacetate Succinimidyl Ester Fluorescent Dye for Cell Labeling." Acta Biochimica et Biophysica Sinica 37, no. 6 (2005): 379–85. http://dx.doi.org/10.1111/j.1745-7270.2005.00051.x.

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Abstract Our objective was to study the properties of the carboxyfluorescein diacetate succinimidyl ester (CFDA-SE) and the methodology of cell labeling using CFDA-SE fluorescent dye. First, we analyzed the kinetics of CFDA-SE fluorescent dye intensity over time. Second, we determined the optimal concentration of CFDA-SE fluorescent dye for cell labeling. Third, we tested the toxicity of CFDA-SE fluorescent dye on labeled cells. Finally, we determined the optimal staining time of CFDA-SE fluorescent dye for cell labeling. The results show that the optimal concentration of CFDA-SE fluorescent d
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24

Dewar, Michael J. S., and Santiago Olivella. "MNDO study of ring opening in the succinimidyl radical." Journal of the Chemical Society, Chemical Communications, no. 5 (1985): 301. http://dx.doi.org/10.1039/c39850000301.

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25

Zalipsky, Samuel. "Alkyl succinimidyl carbonates undergo Lossen rearrangement in basic buffers." Chemical Communications, no. 1 (1998): 69–70. http://dx.doi.org/10.1039/a706713e.

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26

MUJUMDAR, R. B., L. A. ERNST, S. R. MUJUMDAR, C. J. LEWIS, and A. S. WAGGONER. "ChemInform Abstract: Cyanine Dye Labeling Reagents: Sulfoindocyanine Succinimidyl Esters." ChemInform 24, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.199330244.

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27

Chandra, Koushik, Priyadip Das, Samarasimhareddy Mamidi, et al. "Covalent Inhibition of HIV-1 Integrase byN-Succinimidyl Peptides." ChemMedChem 11, no. 18 (2016): 1987–94. http://dx.doi.org/10.1002/cmdc.201600190.

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28

Sadakane, Yutaka, Sayumi Senda, Taku Deguchi, Atsuki Tanaka, Hiromasa Tsuruta, and Shota Morimoto. "Effect of amino acids present at the carboxyl end of succinimidyl residue on the rate constants for succinimidyl hydrolysis in small peptides." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1868, no. 11 (2020): 140496. http://dx.doi.org/10.1016/j.bbapap.2020.140496.

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29

Baumert, Alfred, Andrea Porzel, Jürgen Schmidt, and Detlef Gröger. "Formation of 1,3-Dihydroxy-N-methylacridone from N-Methylanthraniloyl-CoA and Malonyl-CoA by Cell-Free Extracts of Ruta graveolens." Zeitschrift für Naturforschung C 47, no. 5-6 (1992): 365–68. http://dx.doi.org/10.1515/znc-1992-0608.

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N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was characterized by LSIMS and NMR data. An enzyme preparation from cell suspension cultures of Ruta graveolens catalyzed the formation of 1,3-dihydroxy-N-methylacridone from N-methylanthraniloyl-CoA and malonyl-CoA with a pH optimum of 7.5.
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30

Schaz, A., E. Valaityte, and G. Lattermann. "Investigations on liquid crystalline partially fluorinated alkyl and succinimidyl benzoates." Liquid Crystals 32, no. 4 (2005): 513–25. http://dx.doi.org/10.1080/02678290412331329215.

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31

FALLON, RACHEL A., and ALAN D. B. MALCOLM. "Modification of DNA with N-succinimidyl 3-(2-pyridyldithio)propionate." Biochemical Society Transactions 13, no. 2 (1985): 367–68. http://dx.doi.org/10.1042/bst0130367.

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32

Fukuda, Tomohiro, Sotaro Tsuji, and Yoshiko Miura. "Glycopolymer preparation via post-polymerization modification using N-succinimidyl monomers." Polymer Journal 51, no. 6 (2019): 617–25. http://dx.doi.org/10.1038/s41428-019-0170-y.

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33

Asquith, Becca, Christophe Debacq, Arnaud Florins, et al. "Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester." Proceedings of the Royal Society B: Biological Sciences 273, no. 1590 (2006): 1165–71. http://dx.doi.org/10.1098/rspb.2005.3432.

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34

Vaidyanathan, Ganesan, Donna J. Affleck, and Michael R. Zalutsky. "Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate." Bioconjugate Chemistry 4, no. 1 (1993): 78–84. http://dx.doi.org/10.1021/bc00019a011.

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35

Toma, Koji, Koki Oishi, Naoyuki Yoshimura, Takahiro Arakawa, Hiromi Yatsuda, and Kohji Mitsubayashi. "Repeated immunosensing by a dithiobis(succinimidyl propionate)-modified SAW device." Talanta 203 (October 2019): 274–79. http://dx.doi.org/10.1016/j.talanta.2019.05.080.

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36

Boucher, Julie, Élie Simard, Ulrike Froehlich, Pedro D’Orléans-Juste, and Michel Grandbois. "Using carboxyfluorescein diacetate succinimidyl ester to monitor intracellular protein glycation." Analytical Biochemistry 478 (June 2015): 73–81. http://dx.doi.org/10.1016/j.ab.2015.03.017.

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37

KASAI, P. H. "ChemInform Abstract: Succinimidyl and Phthalimidyl Radicals: Matrix Isolation ESR Study." ChemInform 23, no. 31 (2010): no. http://dx.doi.org/10.1002/chin.199231106.

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38

Pal, Biswajit, P. K. Bajpai, Jayati Sengupta, and Vinod Singh. "Vibrational Studies on the Heterobifunctional Cross-linking AgentsN-Succinimidyl 3-(2-Pyridyldithio)propionate andN-Succinimidyl 6-[3′-(2-Pyridyldithio)propionamido]hexanoate and Theoretical Elucidations." Journal of Raman Spectroscopy 28, no. 5 (1997): 323–29. http://dx.doi.org/10.1002/(sici)1097-4555(199705)28:5<323::aid-jrs99>3.0.co;2-9.

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39

Yang, Jun, Fang Li, Ou Zeng та ін. "Conjugation, Identification and Bionomics Analysis of EGFR Targeting Drug TGF α-Saporin as a Bioactive Stent Coating Material". Advanced Materials Research 1120-1121 (липень 2015): 793–97. http://dx.doi.org/10.4028/www.scientific.net/amr.1120-1121.793.

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Objective: To identify and testify the cytotoxicity of the EGFR targeting drug TGFa-SAP conjugated and synthesized with N-succinimidyl-3 (2-pyridyldithio) propionate on human hepatoma cell line BEL-7404 cells and proliferating vascular smooth muscle cells. Methods: Conjugation of saporin with TGFa was accomplished after derivatization of TGFa and saporin with N-succinimidyl-3 (2-pyridyldithio) proprionate and the purification of the conjugate was achieved through Eppendorf Centrifugal Filter. Cytotoxicity assays were measured by MTS assays. The value of Thymidine incorporation in BEL-7404 cell
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40

Jennissen, H. P., and Julia Holtkamp. "Controlling Leakage of Potential Juxtacrine Self-Assembled Monolayer-BMP-2 Surfaces." Current Directions in Biomedical Engineering 9, no. 1 (2023): 134–37. http://dx.doi.org/10.1515/cdbme-2023-1034.

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Abstract A question which has been intriguing researchers since 1969 is whether covalently linked hormones or growth factors on surfaces are still biologically active i.e. still bind and activate cell surface receptors in the insoluble state. The objective of the present work was to find evidence for the absence of any release or leakage of rhBMP-2 covalently linked to self-assembled monolayers (SAMs) prepared from dithiobis(succinimidyl-undecanoate) on gold surfaces.
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41

THOMAS, J. Brandon, Frederick W. HOLTSBERG, C. Mark ENSOR, John S. BOMALASKI та Mike A. CLARK. "Enzymic degradation of plasma arginine using arginine deiminase inhibits nitric oxide production and protects mice from the lethal effects of tumour necrosis factor α and endotoxin". Biochemical Journal 363, № 3 (2002): 581–87. http://dx.doi.org/10.1042/bj3630581.

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Septic shock is mediated in part by nitric oxide (NO) and tumour necrosis factor α (TNFα). NO is synthesized primarily from extracellular arginine. We tested the ability of an arginine-degrading enzyme to inhibit NO production in mice and to protect mice from the hypotension and lethality that occur after the administration of TNFα or endotoxin. Treatment of BALB/c mice with arginine deiminase (ADI) formulated with succinimidyl succinimide polyethylene glycol of Mr 20000 (ADI-SS PEG20000) eliminated all measurable plasma arginine (from normal levels of ∼155μM arginine to 2μM). In addition, ADI
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42

Wu, Zhuning, Stefanie H. Korntner, Jos Olijve, Anne Maria Mullen, and Dimitios I. Zeugolis. "The Influence of Bloom Index, Endotoxin Levels and Polyethylene Glycol Succinimidyl Glutarate Crosslinking on the Physicochemical and Biological Properties of Gelatin Biomaterials." Biomolecules 11, no. 7 (2021): 1003. http://dx.doi.org/10.3390/biom11071003.

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In the medical device sector, bloom index and residual endotoxins should be controlled, as they are crucial regulators of the device’s physicochemical and biological properties. It is also imperative to identify a suitable crosslinking method to increase mechanical integrity, without jeopardising cellular functions of gelatin-based devices. Herein, gelatin preparations with variable bloom index and endotoxin levels were used to fabricate non-crosslinked and polyethylene glycol succinimidyl glutarate crosslinked gelatin scaffolds, the physicochemical and biological properties of which were subs
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43

Nymann Petersen, Ida, Jacob Madsen, Christian Bernard Matthijs Poulie, Andreas Kjær, and Matthias Manfred Herth. "One-Step Synthesis of N-Succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB)." Molecules 24, no. 19 (2019): 3436. http://dx.doi.org/10.3390/molecules24193436.

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Herein, we present a one-step labeling procedure of N-succinimidyl-4-[18F]-fluorobenzoate ([18F]SFB) starting from spirocyclic iodonium ylide precursors. Precursor syntheses succeeded via a simple one-pot, two-step synthesis sequence, in yields of approximately 25%. Subsequent 18F-nucleophilic aromatic labeling was performed, and radiochemical incorporations (RCCs) from 5–35% were observed. Purification could be carried out using HPLC and subsequent solid phase extraction. Radiochemical purity (RCP) of &gt;95% was determined. The total synthesis time, including purification and formulation, wa
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44

Kaushal, Parveen, Brian P. Roberts, and Evelyn J. Ryan. "3-Bromopropanoyl isocyanate as an acyclic source of the succinimidyl radical." Journal of the Chemical Society, Chemical Communications, no. 20 (1987): 1587. http://dx.doi.org/10.1039/c39870001587.

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45

Bardajee, Ghasem Rezanejade, Mitchell A. Winnik, and Alan J. Lough. "Succinimidyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate chloroform solvate." Acta Crystallographica Section E Structure Reports Online 62, no. 7 (2006): o3079—o3081. http://dx.doi.org/10.1107/s160053680602174x.

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In the title molecular structure, C18H18N2O6·CHCl3, the dihedral angle between the two fused, essentially planar, six-membered rings is 5.4 (2)°. In the crystal structure, weak intermolecular C—H...O hydrogen bonds and π–π stacking interactions connect molecules into two-dimensional layers.
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46

Lyons, A. Bruce. "Divided we stand: Tracking cell proliferation with carboxyfluorescein diacetate succinimidyl ester." Immunology and Cell Biology 77, no. 6 (1999): 509–15. http://dx.doi.org/10.1046/j.1440-1711.1999.00864.x.

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47

Vaidyanathan, Ganesan, and Michael R. Zalutsky. "Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates." Bioconjugate Chemistry 1, no. 6 (1990): 387–93. http://dx.doi.org/10.1021/bc00006a004.

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48

Debord, Justin D., and L. Andrew Lyon. "On the Unusual Stability of Succinimidyl Esters in pNIPAm-AAc Microgels." Bioconjugate Chemistry 18, no. 2 (2007): 601–4. http://dx.doi.org/10.1021/bc060248z.

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49

Vaidyanathan, Ganesan, Donna J. Affleck, and Michael R. Zalutsky. "Method for Radioiodination of Proteins UsingN-Succinimidyl 3-Hydroxy-4-iodobenzoate." Bioconjugate Chemistry 8, no. 5 (1997): 724–29. http://dx.doi.org/10.1021/bc9700502.

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50

Skell, Philip S., Ulrich Luning, Douglas S. McBain, and James M. Tanko. "Ground- and excited-state succinimidyl radicals in chain reactions: a reexamination." Journal of the American Chemical Society 108, no. 1 (1986): 121–27. http://dx.doi.org/10.1021/ja00261a020.

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