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Dissertations / Theses on the topic 'Synthesis of isoxazoles'

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Published: 4 June 2021

Last updated: 13 February 2022

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1

Knight, Julian Gary. "Diphenylphosphinoylalkyk isoxazoles and isoxazolines." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306451.

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2

Tout, Jaki. "The synthesis and reactions of alkenyl isoxazoles and isoxazolines." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/14563.

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Four vinyl-isoxazoles and -2-isoxazolines have been synthesised as potential monomers for polymerisation studies. 5-Phenyl-3-vinylisoxazole was prepared in 38% overall yield by a sequence involving cycloaddition of ethoxycarbonyl-formonitrile oxide to phenylacetylene and then reduction of the resulting 3-carbethoxyisoxazole to the aldehyde using di-isobutylaluminium hydride. In the final stage Wittig olefination of the formyl-isoxazole afforded the target compound. 5-Phenyl-3-vinylisoxazole (17%) and 5-phenyl-3-vinyl-2-isoxazoline (26%) were synthesised similarily from ethyl propiolate & benzo

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3

Blackburn, Jack. "The synthesis, attempted synthesis and applications of 1,2,4-oxadiazoles and isothiazolo-isoxazoles." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/26888/.

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4

Duffy, Kevin James. "Studies on the synthesis and reactivity of fused 3,4-isoxazoles." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/13734.

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This thesis is concerned with the synthesis of various fused, 3,4-isoxazoles by the thermal cyclisation of 2-nitroaryl and 2-nitroheteroaryl acetic acid derivatives and the exploitation of the uses of these compounds in heterocyclic synthesis by their reduction to afford 2-aminoaryl and heteroaryl ketones followed by the annulation of these latter derivatives. Heating solutions of 2-(3-nitropyrid-2-yl)propanedioate esters under reflux in inert solvents afforded isoxazolo[4,3-b]pyridine-3-carboxylate derivatives. The successful application of this novel synthesis on a large scale was crucially

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5

Kivrak, Arif. "Development Of New Methods For The Synthesis Of Pyrazoles, 4-iodopyrazoles, Isoxazoles And 1,2,4-oxadiazoles." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612945/index.pdf.

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Synthesis of five-membered heteroaromatic compounds such as pyrazoles, isoxazoles and 1,2,4-oxadiazoles are important for pharmaceutical industry and material science due to their applications. Although there are many methods to prepare such compounds, new variants continue to appear since they exhibit a wide range of biological and medicinal activities. In this thesis, new methods were developed for the synthesis of 4-iodopyrazoles, pyrazoles, isoxazoles, 1,2,4-oxadiazoles and/or 1,2,4-oxadiazepines. In the first part of the study, electrophilic cyclization of &alpha<br>,&beta<br>-alkynic hy

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6

FALCOU, SERGE, and André Pierre Joseph Rassat. "Utilisation des isoxazoles en synthese : approche de la synthese de la phyllanthocine." Paris 6, 1995. http://www.theses.fr/1995PA066314.

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La synthese de la phyllanthocine et en particulier du systeme spirocetal bicyclique 6,5 fait intervenir la condensation aldolique de l'enolate du 3-acetylisoxazole sur un hydroxyaldehyde methyle. Apres la mise au point de la synthese de cet isoxazole inconnu, et suite a la mauvaise reactivite de l'enolate de cet isoxazole, une modification de la strategie de synthese nous a conduit a realiser un umpolung en condensant un alcynure sur le 3-carbomethoxyisoxazole. Cette strategie permet d'acceder au produit d'aldolisation precedemment souhaite par addition conjuguee diastereoselective d'un hemiac

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7

Moschref, Said-Nadjib. "Synthese und Umlagerung von mono-metallierten Bisallylethersystemen und die Synthese von mono-metallierten Isoxazolen." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=962341290.

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8

Lanson, Marc. "Isoxazoles polyalkyles : synthese, etude structurale et comportement en milieu biologique." Paris 6, 1987. http://www.theses.fr/1987PA066468.

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9

Michaud, Thierry. "Synthese d'heterocycles azotes enatiomeriquement purs (aziridines, azetidines, isoxazoles) au depart de monosaccharides." Clermont-Ferrand 2, 1995. http://www.theses.fr/1995CLF21711.

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Un axe important de la chimie des glucides est leur utilisation comme source de chiralite dans la synthese de molecules a proprietes biologiques potentielles. Notre objectif a ete la synthese d'azetidines polyhydroxylees substituees en 2 et 3, enantiomeriquement pures, au depart de monosaccharides. Des ditosylates en 4,6 ont ete prepares en quatre etapes au depart des d-gluco- et d-mannopyranose par acetalisation, c-alkylation, hydrolyse et tosylation. Dans la serie du d-glucopyranose l'action d'amines primaires (methyl-, benzyl-, et tertbutylamine) sur les derives ditosyles permet d'acceder,

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10

Fritz, Martina Désirée. "p38 MAP Kinase Inhibitoren : Synthese, Analytik und biologische Testung substituierter Isoxazole /." [S.l. : s.n.], 2004. http://www.gbv.de/dms/bs/toc/39191703X.pdf.

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11

Thenna, Hewa Kosala R. S. "Applications Focused Synthetic Modification on Photoremovable Protecting Groups (PRPG) & Photochemical Analysis on Organic Azides and Isoxazoles." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511858669354976.

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12

Khan, Pasha Moeenuddin. "Application of Pd Catalyzed Alkylation: Synthesis of Bicyclic Furans, Isoxazolines and New Cyclopentane Amino acid Analogs." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002792.

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13

Springsteel, Mark Francis. "Synthesis of flavones, isoxazolines and related heterocycles : the search for small molecule drugs to treat cystic fibrosis /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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14

Tampieri, Alberto. "Synthesis, reactivity and applications of 3,5-dimethyl-4-nitroisoxazole derivatives." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10014/.

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3,5-dimethyl-4-nitroisoxazole derivatives are useful synthetic intermediates as the isoxazole nucleus chemically behaves as an ester, but establish better-defined interactions with chiral catalysts and lability of its N-O aromatic bond can unveil other groups such as 1,3-dicarbonyl compounds or carboxylic acids. In the present work, these features are employed in a 3,5-dimethyl-4-nitroisoxazole based synthesis of the γ-amino acid pregabalin, a medication for the treatment of epilepsy and neuropatic pain, in which this moiety is fundamental for the enantioselective formation of a chiral center

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15

Bathich, Yaser. "Synthesis of branched amino polyols and amino hydroxy acids stereoselective addition of C-nucleophiles to isoxazolines and isoxazolinium salts and assignment of configurations /." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-26179.

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16

Silva, Filipe André Nascimento. "Avaliação antioxidante de 3,5-dimetil isoxazol, pirazóis e tiazóis utilizando o método ORAC (capacidade de absorção de radicais oxigênio)." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-27052011-111106/.

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Os radicais livres são espécies químicas que reagem rapidamente com diversos compostos e alvos celulares, por possuírem tempo de meia vida muito curto e serem espécies altamente instáveis. A formação destes compostos constitui uma ação contínua e fisiológica, cumprindo funções biológicas essenciais as quais ocorrem pela perda ou adição de um único elétron a um composto não radicalar. Estas reações podem ocorrer em processos bioquímicos do sistema imune ou químicos, causando prejuízo às células através da destruição de componentes, como proteínas, lipídios, açúcares e nucleotídeos. Sabe-se que

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17

Deden, Tobias [Verfasser], and T. J. J. [Gutachter] Müller. "Diversitätsorientierte Synthesen von Isoxazol-Fluorophoren auf Basis Palladium-katalysierter Multikomponentenreaktionen / Tobias Deden ; Gutachter: T, J. J. Müller." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1208915061/34.

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18

Bruyat, Pierrick. "Synthèse de molécules peptidomimétiques pour inhiber la formation de biofilms bactériens." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR136.

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La plupart des bactéries vivent en communautés organisées, appelées biofilms, augmentant leur résistance aux traitements antibiotiques. Ainsi, la formation de biofilms sur les organes et matériels médicaux est considérée comme la cause de la majorité des infections bactériennes. Il est alors important de trouver des traitements pour empêcher ou perturber la formation de ces biofilms. Il a été proposé que les porines de P. Stuartii, Omp-Pst1 et Omp-Pst2, peuvent s’auto-assembler via un steric-zipper, étape responsable du développement initial du biofilm. Ainsi, notre objectif est de synthétiser

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19

Aleksandar, Oklješa. "Sinteza i biološka aktivnost novih steroidnih heterocikličnih jedinjenja." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=94966&source=NDLTD&language=en.

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U ovoj doktorskoj disertaciji ispitane su 1,3-dipolarnecikloadicione reakcije steroidnih azido-nitrila, nitrona initril-oksida, pri čemu su sintetizovana različitaheterociklična steroidna jedinjenja androstanske i estranskeserije. Utvrdjene su strukture novosintetizovanihjedinjenja. Ispitana je biolo&scaron;ka aktivnost odabranihjedinjenja.<br>In this PhD thesis 1,3-dipolar cycloadditions ofsteroidal azido-nitriles, nitrones and nitrile-oxide wereexamined. Various steroidal heterocyclic compounds inthe androstane and estrane series were synthesised. Thestructural characterisation of newly synt

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20

Wirtz, Lisa [Verfasser], and Uli [Akademischer Betreuer] Kazmaier. "Entwicklung einer effizienten Synthese von Isoxazolin-Aminosäureesterderivaten : Entwicklung und Anwendung von 7-Dialkyl-Aminocumarin-Fluoreszenz-Labels / Lisa Wirtz. Betreuer: Uli Kazmaier." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052338682/34.

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21

Roy, Amélie. "Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives, scope and limitations ; and Aqueous rhodium-catalyzed Heck-type coupling reactions between boronic acids and olefins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/MQ53366.pdf.

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22

Becker, Tobias [Verfasser], Wilhelm [Gutachter] Boland, Georg Gutachter] Pohnert, and Wittko [Gutachter] [Francke. "3-Nitropropanoic acid and isoxazolin-5-one derived glucosides in chrysomelina larvae : synthesis, biosynthesis, occurrence and toxicity / Tobias Becker ; Gutachter: Wilhelm Boland, Georg Pohnert, Wittko Francke." Jena : Friedrich-Schiller-Universität Jena, 2017. http://d-nb.info/1177602245/34.

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23

Hewings, David Stephen. "Developing inhibitors of bromodomain-histone interactions." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:7ee6647c-4ac7-41ba-9f15-dfd49de9f6c2.

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Lysine acetylation is a widespread protein post-translational modification that influences diverse cellular processes. An association between acetylation of histone N-terminal tails and transcriptional activation has been recognised since the 1960s. However, it has only become apparent since 2000 that many of the effects of histone acetylation are mediated by proteins that bind to acetyl-lysine through a specialised acetyl-lysine recognition domain, the bromodomain. Small-molecule inhibitors of bromodomain-histone interactions can greatly assist studies into the functions of bromodomain-contai

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24

RUHLAND-FRITSCH, BEATRICE. "Synthese et etude pharmacologique de derives benzeniques d'analogues du gaba." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR13056.

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25

Bleger, Andrée. "Syntheses associatives au depart d'adenosine et d'agonistes gaba-ergiques." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13073.

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Synthese associative entre l'adenosine et le gaba ou des molecules apparentees. La substitution de l'adenosine par des analogues gaba-ergiques en position 6 a ete realisee soit par alkylation de l'azote n1 suivie d'un rearrangement de dimroth soit par substitution nucleophile du chloro-6 purine riboside. Des modifications au niveau de la sequence gaba et au niveau de l'adenosine ont ete envisagees. La comparaison des profils pharmacologiques de ces molecules a mis en evidence la necessite de la presence du ribose sur l'adenine et a montre que l'activite maximale correspondait au derive de l'ad

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26

Melot, Jean-Marie. "Activation anionique des nitroalcanes par le systeme fluorure de potassium-alumine : application a la synthese de nitroalcools, cyclopropanes, dihydrofurannes et isoxazolines-n-oxydes. reaction des esters nitroacetiques avec les imines en presence de tamis moleculaires." Rennes 1, 1987. http://www.theses.fr/1987REN10124.

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27

Moores, Lee C. "Malononitriles and cyanoacetamides containing isoxazoles and isoxazolines." 2011. http://liblink.bsu.edu/uhtbin/catkey/1657737.

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Isoxazoles and isoxazolines have been shown in the literature to be an important scaffold for pharmaceuticals and insecticides, as well as a source of synthetic versatility important to many syntheses. As a substitute for other aromatic rings, isoxazoles are known to change the efficacy of a given compound. Isoxazolines can be used as a precursor to many other functional moieties that may be effected during earlier synthetic steps. There are many routes to the heterocyclic moiety, allowing for their insertion in a wide range of molecules. Our group has previously reported a condensation of ary

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28

Tsai, Ming-Tsung, and 蔡明宗. "Synthesis of Heteroaryl-Isoxazolines, Isoxazoles and Triazoles Substituted Calix[4]arenes." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/94253002342033910051.

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碩士<br>國立交通大學<br>應用化學系所<br>93<br>Calixarenes, which are cavity-containing compounds, are very useful molecular platforms in molecular recognition research. There has been a growing interest in modifying calixarenes with two or more binding sites. We have developed a high yield and convenient method in modifying calixarene with various heterocyclic compounds by 1,3-dipolar cycloaddition reation either on the “lower rim” or on the “upper rim”. The isoxazolines and isoxazoles 62–71 obtained from these reactions are known to be very useful precursors for various bifunctional compounds by ring-ope

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29

Huang, Hon-Cha, and 黃浤珈. "Synthesis and Cytotoxic Activities of 4,5-Disubstituted isoxazoles and pyrazoles." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/30026283384892445645.

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碩士<br>中國文化大學<br>應用化學研究所<br>98<br>Abstract Combretastatin A-4 (CA-4), a naturally occurring stilbene, was isolated from Combretum caffrum (African bush willow). CA-4 strongly inhibited the polymerization of tubulin by binding to the colchicine site and showed potent cytotoxicity against a variety of human cancer cell lines including multiple drug resistant cancer cell lines. CA-4 also showed strong anti-vascular activity. In the previously comparative studies of the combretastatins it appears that the cis orientation of the two aromatic rings plays an important role of cytotoxicity. Therefore,

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30

Wang, Shu-Huei, and 王淑惠. "Synthesis of Pyrazoles and Isoxazoles from Allenyl Ketones and A New Additional Reaction for Synthesis of b-Halo Ketones." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/85930026189372885183.

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博士<br>淡江大學<br>化學學系博士班<br>93<br>Part I: Pyrazole and Isoxazole are well-known as useful synthetic intermediates and important structural units which are widely observed in natural products and biological active molecules. Several methods for synthesis of isoxazoles have been developed and reported and the cyclocondensation reaction of b-diketone with hydroxylamine is one of the most common used method. The limitation of this method is the unsymmetrical b-dicarbonyl compounds can not be prepared regioselectively. The condensation reactions of oxime dianions with esters provide a regioselective a

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31

Kuang-PoChen and 陳光伯. "1.Synthesis of 1,4-quinones and spiro compounds via manganese(III) acetate mediated free radical reactions2.Ionic methodology in synthesis of isoxazoles and 2,3- dihydrofurans." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/02999461490039992435.

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博士<br>國立成功大學<br>化學系碩博士班<br>101<br>Part 1 Free radical reaction 1.A free radical reaction medicated by manganese(III) acetate between 2-benzoyl-1,4-benzoquiones and 1,3-dicarbonyl compounds produces benzo[c]furan-4,7-diones 34 and anthracene-1,4-diones 35 with chemoselectivity. 2.A free radical cyclization reaction mediated by Mn3+ between TsNa and N-(β-allylsulfonylpropionyl)-4-methoxy- naphthylamine 65 can produce spirolatam 75 without any 6-endo-trig product. Part 2 Heterolytic reaction 1.Highly functionalized isoxazoles can be synthesized from ethyl α- nitrocinnamates 60 and ethyl nitr

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32

Li-Kuo-Wei and 李國維. "Synthesis and Properties of Isoxazolones Derivatives." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/62541166566648355196.

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碩士<br>國立臺灣科技大學<br>纖維及高分子工程系<br>90<br>In this study, the reaction of Hydroxylamine hydrochloride with Benzoylacetic acid ethyl ester and Ethyl acetoacetate was shown to give compounds 3 and 6. First, a solution of compound 3 and 6 in ethanol was condensed with aromatic aldehyde derivatives by presence of basic catalyst was shown to give compounds 8a~8f and 9a~9b. Second, a solution of compound 3 and 6 were coupled with aromatic benzylamine derivatives. Finally, these compound were determined the structure by spectrometry（UV、FTIR、1H-NMR） and element analysis（EA）.

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33

Chen, Yu-jyun, and 陳裕君. "The synthesis of benzo[b]fluorene and isoxazole." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/67198958583781946321.

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碩士<br>國立成功大學<br>化學系碩博士班<br>97<br>Formation of C-C bond can be achieved either by ionic reactions or radical reactions. Oxidative free radical reaction mediated by metal salts has attracted attention in organic synthesis. Manganese(III) acetate and cerium(IV) ammonium nitrate have been the most efficient among these metal salts. In this thesis, carbon radical generated by oxidation of ethyl cyanoacetate or dimethyl malonate with the manganese(III) acetate undergo addition to 2-aryl-1,4-naphthaquinones effectively and benzo[b]fluorene was produced. Pyridinium ylide can be generated by the dep

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34

Chang, Kai-Chi, and 張凱奇. "Synthesis of Fluorogenic Calix[4]arenes with Isoxazoline and Isoxazole Substituents." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/48675420192201066960.

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碩士<br>國立交通大學<br>應用化學系所<br>92<br>Flexibility endows the calixarenes with a dimension that at times can be frustrating but that also makes possible the fashioning of cavities of highly varied shapes and contours, and forming complexes with specific guests. Modifying the mono- and di-substituted allyl groups on the lower rim of calix[4]arenes by 1,3-dipolar cycloaddition reaction may lead to chiral and fluorescent isoxazoline calix[4]arenes, which are not only useful for sensor of metal ion but also good for chiral recognition. Besides, ring-opening reactions of the isoxazoline calix[4]arenes

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35

yuan, Chuang shun, and 莊舜淵. "Synthesis and Cytotoxic activity of 4-(indolyl)-5-(3,4,5-trimethoxyphenyl) isoxazole." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/26896720340144652012.

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碩士<br>中國文化大學<br>應用化學研究所<br>95<br>Combretastatin A-4 (CA-4), a natural product isolated from Combretum caffrum, strongly inhibited the polymerization of tubulin by binding to the colchicine site, and it showed strong cytotoxicity against a variety of human cancer cells. To date, many CA-4 analogues and their anticancer activity have been extensively studied. Its water-soluble derivative, sodium phosphate prodrug (CA-4P), is currently evaluated for clinical applications. The structure–activity relationship analysis of the combretastatins indicated that the cis configuration of the two aromat

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36

Xu, Ya-Zhu, and 許雅筑. "Synthesis of Isoxazole, Triazole and Naphthalidene Derivatives and Their Applications in Metal Ion Sensing." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/88245364179488604536.

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碩士<br>國立交通大學<br>應用化學系所<br>96<br>Synthesis of Isoxazole, Triazole and Naphthalidene Derivatives and Their Applications in Metal Ion Sensing (1) Application of isoxazole and triazole modified calix[4]arenes as metal ion sensing Using Click chemistry, which was promoted by professor K. B. Sharpless, we successfully synthesized p-nitrophenylazo-isoxazole- calix-[4]arene 32 and p-nitrophenylazo-anthryl-triazole-calix[4]-arene 34. Based on the results from UV-Vis spectroscopy, we found that compound 32 could recognize Ca2+ and Pb2+, however with a poor sensitivity. When compound 34 was complexed wi

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37

Guan, Qiao-Zhi, and 官巧之. "Synthesis of Chiral Isoxazole Derivatives Employing Bifunctional Thiourea Organocatalyst and 1,5-difluoro-2,4-dinitrobenzene." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04658731297954677104.

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碩士<br>國立臺灣師範大學<br>化學系<br>99<br>This thesis deals with the synthesis of biologically active chiral bicyclic isoxazole and isoxazoline derivatives. The synthetic methodology involves two steps. In the first step, β-nitrostyrene derivatives were treated with allyl or propargyl malonates in the presence of chiral bifunctional thiourea catalyst to obtain the corresponding optically active Michael adducts. The resultant chiral Michael adducts were treated with DBU and 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to generate nitrile oxides in situ. The nitrile oxide intermediates underwent intramolecular

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38

Tsai, Chia-Chen, and 蔡佳蓁. "Syntheses, Properties, and Applications of bis- Isoxazolyl-aryl Substituted Biscalixarene Derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/74514483221789511593.

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博士<br>國立交通大學<br>應用化學系碩博士班<br>101<br>In recent years, biscalix[4]arenes have been extensively studied because their structures usually contain interesting properties including the allosteric effect, intramolecular oscillation, and conformational interconversions. We have been using a strategy to construct a variety of functionalized isoxazoline and isoxazole unit(s) onto the calix[4]arene skeletons through double and/or quadruple 1,3-dipolar cycloaddition reactions of alkynes with aryl nitrile oxides. To our delight, these new series of biscalixarene derivatives contain various interesting prop

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39

Nuzlia, Cut, and 纽思麗亞. "Synthesis of Triazole and Isoxazole Through Three Component Coupling Reaction Followed by Intramolecular [3+2] Cycloaddition." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/9tfrk2.

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碩士<br>國立東華大學<br>化學系<br>102<br>ABSTRACT Three component coupling reaction followed by intramolecular [3+2] cyloaddition for the synthesis of triazoles and isoxazoles was described. Synthesis of triazoles consisted of two steps, the first step involved AuBr3-catalyzed three component coupling reaction of terminal alkyne, aldehydes and amine under solvent-free condition to provide the propargylamines with short reaction time, high diastereoselectivities and environmental benign. The second step, propargylamines undergoes catalyst free intramolecular azide-alkyne [3+2] dipolar cycloaddition reac

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Tsai, Chia-Chen, and 蔡佳蓁. "Syntheses of Anthryl-Isoxazole Substituted Biscalix[4]arene Derivatives as Fluorogenic Sensors in Molecular Recognition." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/65130123932278822169.

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碩士<br>國立交通大學<br>應用化學系所<br>97<br>In this work, we have synthesized biscalix[4]arenes 42-46 using 1,3-dipolor cycloaddittion reactions. Our synthetic strategy for linking two calix[4]arenes involves double and quadruple cycloaddition between aryl dinitrile oxides and propargyl groups to form isoxazole biscalix[4]arenes, 42, 44 and 46. Mo(CO)6–mediated ring opening reaction of isoxazole linked biscalix[4]arenes 42 and 44, led to biscalix[4]arenes with enaminone groups, 43 and 45. Based on 1H�n�nNMR spectroscopy, we found that compound 45 composed of two atropisomers, because there is a hinder

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Wan-yu, Lin, and 林宛諭. "Synthesis Chiral Isoxazole Derivatives via 1,3-dipolar Cycloaddition from Michael Adducts by Using Difucntional Thiourea an Organocatalyst." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/90147113050256226100.

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碩士<br>國立臺灣師範大學<br>化學系<br>100<br>Isoxazole and isoxazoline derivatives are common and can be found in the nature compounds. The isoxazole derivatives structure are stable and facilitate for variety synthesis as intermediates. In medical system, enantiomeric isoxazole and isoxazoline are used in therapeutic process. Therefore, it becomes major tasks for synthesis enantiomeric isoxazole and isoxazoline. We have recently prepared nitrostyrene and dimethyl allyl malonate (and dimethyl propargyl malonate) with additive chiral bifunctional thiourea for 1,4-Michael addition. With H-bonding, the thiour

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Moschref, Said-Nadjib [Verfasser]. "Synthese und Umlagerung von mono-metallierten Bisallylethersystemen und die Synthese von mono-metallierten Isoxazolen / vorgelegt von Said-Nadjib Moschref." 1999. http://d-nb.info/962341290/34.

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Kuo, Ming-Luen, and 郭明倫. "Syntheses of Phenols and Calix[4]arenes with Isoxazoline or Isoxazole and Their Ring Opening Derivatives and Metal Ion Sensing Studies." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/75v352.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>107<br>We modified the lower rim of calix[4]arenes with isoxazoline or isoxazole to get the anthracene derivatives 18, 25a and 25b. by 1,3-dipolar cycloaddition. However, we could not synthesize the corresponding calix[4]arene derivatives with β-hydroxy-ketone or β-amino-α,β-unsaturated-ketone after trying the kinds of reaction conditions. Then we introduced the five member ring of isoxazole into phenol, o-benzenediol and m-benzenediol and successfully synthesized the β-amino-α,β-unsaturated-ketone derivatives 30, 34 and 38 by using Mo(CO)6 to carry out the ring-op

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Bathich, Yaser [Verfasser]. "Synthesis of branched amino polyols and amino hydroxy acids : stereoselective addition of C-nucleophiles to isoxazolines and isoxazolinium salts and assignment of configurations / vorgelegt von Yaser Bathich." 2006. http://d-nb.info/980369746/34.

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Chen, Tyng-Rong, and 陳庭蓉. "(I)Hydrogen, Halogen Bonding and Metal Ion-Induced Two Component Gel Formation of Triazolyl-pyridyl Substituted Calix[4]arene Derivatives (II)Syntheses of bis-Isoxazolyl-aryl Substituted Biscalix[4]arene Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/jvy7sf.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>102<br>In recent years, calix[4]arene derivatives have been extensively studied in supramolecular gel formation. Although they can be used in ions recognition and oil spill recovery, they usually form one component gels. Two component gel formation of calix[4]arene was not known until Prof. Zheng’s work published in 2007. It worth noting that there have been few reports on using halogen bonding as intermolecular forces for gel formation. In this thesis, we used click chemistry reaction to synthesize triazolyl-pyridyl substituted calix[4]arene derivatives 33 , whic

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