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Dissertations / Theses on the topic 'Synthesis of quinoline'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Barr, Stephen Alexander. "Quinoline alkaloids : synthesis and stereochemistry." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333796.

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2

Klaas, Phindile Jonathan. "Novel approaches to the synthesis of quinoline derivatives." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1004751.

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The investigation has been concerned with the application of the Baylis-Hillman methodology to the synthesis of quinoline derivatives. An extensive range of novel Baylis-Hillman products has been prepared, typically in moderate to excellent yields, by condensing 2-nitrobenzaldehyde derivatives with various vinyl ketones and acrylic esters in the presence of diazabicyclo[2.2.2]octane (DABCO). Reduction of the nitro group in the Baylis-Hillman products was effected by catalytic hydrogenation in ethanol using a 10% palladium-on-carbon catalyst to afford quinoline, quinoline-N-oxide and quinolone

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3

Neville, Charles Frederick. "The synthesis and biosynthesis of quinoline alkaloids." Thesis, University of Ulster, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481119.

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4

Velioglu, Ozlem. "Synthesis Of Ferrocenyl Substituted Quinolines." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609785/index.pdf.

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Quinolines have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of quinolines with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted quinolines, such as 2-ferrocenylquinoline, by

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5

Haddad, Jalal. "Synthesis and chemistry of some quinoline-5,8-diones." Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/917048.

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The synthesis of several 7-substituted analogs of 2-methylquinoline-5,8-dione and their chemistry are described. In this investigation the following compounds were prepared.5,7-Diformamido-8-hydroxy-2-methylquinoline (207), 7-formamido-2methylquinoline-5,8-dione (199), 7-acetamido-2-methylquinoline-5,8-dione (6), 7-isobutyramido-2-methylquinoline-5,8-dione (200), 7-amino-2-methylquinoline-5,8-dione (210), 7-amino-6-chloro-2-methylquinoline-5,8-dione (213), 7-methoxy-2-methylquinoline5,8-dione (214), 7-ethoxy-2-methylquinoline-5,8-dione (215), 7-isopropyloxy-2methylquinoline-5,8-dione (216), 7-

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6

Watters, William Henry. "Studies towards the synthesis of hemiterpenoid quinoline alkaloids." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241684.

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7

Mazzanti, Stefano. "A novel atroposelective strategy for the synthesis of quinoline substrates." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16660/.

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Among heterocyclic compounds, quinoline scaffold has become an important motif for the development of new pharmacological active compounds. Since the discovery of their antimalarial properties, a large variety of quinolines was found to have interesting physiological activities and displayed attractive applications for pharmaceutical industries. In accordance to the above-mentioned features, a number of methods were developed for their synthesis but enantioselective versions are still lacking in the literature. In the past decades, this question has become even more complex, with the emergenc

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8

Hamilton, Lynne. "Synthesis, stereochemistry and reactions of quinoline, isoquinoline and acridine metabolites." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334710.

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9

Loke, P. L. "Chemoenzymatic and chemical synthesis of enantiopure quinoline derivatives and alkaloids." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273295.

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10

Rahman, Adrian. "The synthesis of new tricyclic beta lactams based upon quinoline." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366356.

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11

Bar, GreÌgory L. J. "Manganese(III) acetate-mediated radical reactions in organic synthesis." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274499.

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12

Shi, Aibin. "Synthesis and bioactivities of substituted quinolines and nanogels." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1638.

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13

Reynolds, Kristie Anne. "Design and Synthesis of Quinoline, Cinchona Alkaloids and Other Potential Inhibitors or Leishmaniasis." Thesis, Griffith University, 2012. http://hdl.handle.net/10072/367771.

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The synthesis and biological activity of Trypanothione mimics and a series of quinoline derivatives designed as potential antileishmanial chemotherapies is reported. The biosynthesis of trypanothione is a unique pathway for parasites such as Leishmania and trypanosomes. A structure-guided design of trypanothione mimics led to the identification of 4 target compounds. Compounds 93 and 94 were designed to mimic the left-hand side chain, while compounds 105 and 106 mimicked side chains of molecule 59. The selected side chain mimics have not been previously assessed for their potential as TryR in

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14

Melis, Diana. "Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies." Master's thesis, Faculty of Science, 2020. http://hdl.handle.net/11427/32414.

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Malaria is a devastating and pervasive infectious disease and continues to be a major global health issue, with over half the world's population being at risk of transmission. In the absence of a suitable vaccine, efforts to eradicate the disease rely heavily on clinically available drugs. Plasmodium falciparum, the deadliest species of malaria, has however become resistant to most conventional antimalarial treatments, resulting in the worldwide search for new, effective drugs. Amongst other requirements, these drugs should target resistant parasitic strains in an attempt to curb the escalatio

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15

Zehr, Peter S. "Synthesis of novel alkaloids using squaric acid esters." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4411.

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Thesis (Ph. D.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains xvii, 207 p. : ill. Includes abstract. Includes bibliographical references (p. 97-101).

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16

Ngororabanga, Jean Marie Vianney. "Synthesis of fluorescent polymers with pendant triazole-quinoline groups via raft polymerization." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/d1020798.

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In this study, fluorescent polymers with pendant quinoline groups were synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT) from a fluorescent quinoline-based vinyl monomer, synthesized in multiple steps from p-nitroaniline and crotonaldehyde. The structures of the synthesized vinyl monomer and polymers were confirmed by NMR and FT-IR spectroscopy, X-ray studies and modeling stdies. The photophysical properties of the synthesized quinoline compounds and resulting polymers were investigated. In order to evaluate the binding potential of our quinoline-based polym

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17

Pretorius, Izak Stefanus. "Synthesis, characterisation and antimalarial activity of quinoline–pyrimidine hybrids / Izak Stefanus Pretorius." Thesis, North-West University, 2012. http://hdl.handle.net/10394/8105.

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The world suffers under the immense threat of malaria with about 1 million people dying and a further 500 million people getting infected and debilitated by the disease each year. It has a negative effect on the economic growth in developing countries that already battles with political unrest, civil wars, famine and the effect of diseases like tuberculosis and HIV/AIDS. Resistance against the first line drugs such as the quinolines and the antifolate combination drugs makes the fight against malaria increasingly difficult and has prompted studies into alternative chemotherapeutic treatments o

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18

Vlok, Martha Carolina. "Artemisinin-quinoline hybrids :|bdesign, synthesis and antimalarial activity / Martha Carolina (Marli) Vlok." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9543.

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Introduction - Malaria is a major global health problem, with more than 500 million reported cases and at least 1 million deaths each year. The main problem with malaria control is the emerging drug resistance. Plasmodium falciparum (P. falciparum) developed widespread resistance to antimalarial drugs such as chloroquine (CQ) and mefloquine, but not to the artemisinins. The World Health Organization (WHO) recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria in all chloroquine resistance areas. However, P. falciparum has recently started to display resis

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19

Banini, Serge R. "Palladium-catalyzed syntheses of indoles, pyrroloindoles, quinolines a base-mediated formation of N-alkoxyindoles, and progress toward the first total synthesis of echinosulfone A /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5710.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xv, 275 p. : ill. Includes abstract. Includes bibliographical references (p. 107-113).

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20

Kerry, Mark Anthony. "The design and synthesis of novel topoisomerase I poisons." Thesis, University of Sunderland, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245780.

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21

Nsumiwa, Samkele. "Synthesis and investigation of quinoline based ß-haematin formation inhibitors as potential antimalarials." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/12176.

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Includes abstract.<br>Includes bibliograhical references.<br>The question of whether or not replacing the 7-chloro group in the 4-aminoquinoline moiety with an electron withdrawing and hydrophilic substituent results in retention of antiplasmodial activity in the 4-aminoquinoline class of compounds was investigated...

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22

Kgokong, Joseph Lebese. "Trifluoromethyl-substituted quinoline and tetrazole derivatives :design, synthesis, antimalarial activity and cytotoxicity / Joseph L. Kgokong." Thesis, North-West University, 2008. http://hdl.handle.net/10394/3732.

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Malaria is a complex parasitic disease caused by the Plasmodium falciparum. It has been found to be responsible for the death of many people particularly in under-developed and developing countries. For many years chloroquine and quinine have been the mainstay of therapy for this disease. The research on new therapies against malaria have been hampered by factors such as the development of resistance against these and some of the new drugs or combinations thereof, the lack of adequate knowledge on the exact causes and mechanisms of resistance to the drugs and their mode of action, together wit

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23

Duffey, John. "Chemical and enzyme catalysed hydroxylation pathways in the synthesis of arene oxides and quinoline alkaloids." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295411.

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24

Horn, Mark A. "Studies toward the synthesis of the A-B ring system of lavendamycin methyl ester." Virtual Press, 1987. http://liblink.bsu.edu/uhtbin/catkey/515490.

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The synthesis of 7-amino-2-methylquinoline-5-8-dione (17) and 7-amino-3-methylquinoline-5,8-dione (157) are described.7-Amino-3-methylquinoline-5,8-dione (157) was prepared via alkaline hydrolysis of 7-acetamido-3-methylquinoline5,8-dione (149). 7-Acetamido-3-methylquinoline-5,8-dione (149) was prepared via the Diels-Alder reaction of 2-acetamido-6-bromo-1,4-benzoquinone (6) and 2-methyl-2propenal dimethylhydrazone (110).7-Amino-2-methylquinoline-5,8-dione (17) was prepared by the acid hydrolysis of 7-(triphenylphosphineimino)-2methylquinoline-5,8-dione (16). 7-(Triphenylphosphineimino)2-methy

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25

Li, Xuesong. "Synthesis and physical properties of helical nanosized quinoline-based foldamers : structure, dynamics and photoinduced electron transport." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0013/document.

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Ce travail présente la synthèse, la caractérisation et l’utilisation (transfert électronique photo-induit) de foldamères de taille nanométriques constitués d’unité quinolines. Grâce a une stratégie de synthèse de doublement de segment une grande variété d’oligomères (jusqu’à 96 unités) ont pu être préparé à partir du synthon 8 aminoquinoline-2-carboxylate.Leurs propriétés dynamiques de ces objets ont été étudiées en solution et en phase gazeuse. La spectrométrie de masse de mobilité ionique a permis de déterminer leur conformation en phase gazeuse. Les expériences de RMN DOSY et d’anisotropie

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26

Devaux, Floriane. "Synthesis and AFM-based single-molecule force spectroscopy of helical aromatic oligoamide foldamers." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0346.

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Les foldamères sont des architectures moléculaires synthétiques repliées, inspirées par les structures et les fonctions des biopolymères naturels. Le repliement est un processus sélectionné par la nature pour contrôler la conformation de sa machinerie moléculaire afin de réaliser des tâches chimiques ou mécaniques. Durant les dix dernières années de recherche sur les foldamères, des oligomères synthétiques, capables d'adopter des conformations repliées bien définies et prévisibles, comme des hélices, ont été proposés. Les progrès récents ont montré que la synthèse chimique par étapes et le des

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27

Tukulula, Matshawandile. "The design and synthesis of novel HIV-1 protease inhibitors." Thesis, Rhodes University, 2009. http://eprints.ru.ac.za/1563/.

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28

Voûte, Nicholas. "Rearrangements in the indolo[2,3-b]quinoline system : a novel approach to the synthesis of perophoramidine and the communesins /." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/486.

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29

Colomb, Julie. "Synthèse et radiomarquage de ligands des récepteurs sérotoninergiques 5-HT6 et 5-HT7 pour la tomographie par émission de positons." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10173/document.

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Le développement de radiotraceurs (18F) des récepteurs de la sérotonine 5-HT6 et 5-HT7 pour l'imagerie TEP (tomographie par émission de positons) permettrait d'étudier la fonction et l'implication de ces récepteurs dans des maladies neurodégénératives telles que la schizophrénie ou la maladie d'Alzheimer. A partir des structures et pharmacophores déjà décrits dans la littérature, nous nous sommes orientés vers des dérivés pyrrolidiniques pour les récepteurs 5-HT7 et quinolines pour les récepteurs 5-HT6. 7 radioligands des récepteurs 5-HT7 marqués au fluor 18 ont pu être étudiés par autoradiogr

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30

Meola, Alain. "Les quinolones : étude chimique et pharmacologique, synthèse." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2P090.

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31

Gadakh, S. K. "Enantioselective synthesis of bioactive molecules and development of synthetic methodologies involving formation of quinoline and coumarin derivatives via Rh-catalyzed ortho C-H bond activation of aromatics." Thesis(Ph.D.), CSIR-National Chemical Laboratory, 2015. https://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5939.

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Enantioselective Synthesis of Bioactive Molecules and Development of Synthetic Methodologies Involving Formation of Quinoline and Coumarin Derivatives via Rh-Catalyzed ortho C-H Bond Activation of Aromatics Research Student: Sunita K. Gadakh AcSIR Roll: 10CC11J26017 Research Guide: Dr. A. Sudalai The thesis entitled “Enantioselective Synthesis of Bioactive Molecules and Development of Synthetic Methodologies Involving Formation of Quinoline and Coumarin Derivatives via Rh-Catalyzed ortho C-H Bond Activation of Aromatics’’ is divided into four chapters. The title of the thesis clearly refle

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32

DeBord, Michael. "Synthesis, characterization, and anti-cancer structure-activity relationship studies of imidazolium salts." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1489414733025495.

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33

Das, Hari Sankar [Verfasser], and Biprajit [Akademischer Betreuer] Sarkar. "Ruthenium complexes with non-innocent quinonoid, quinoline-5,8-dione and iminoquinone ligands : synthesis, structure, redox properties and electron distribution / Hari Sankar Das. Betreuer: Biprajit Sarkar." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2012. http://d-nb.info/102604331X/34.

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34

Saggadi, Hanen. "Valorisation du glycérol sous irradiation micro-ondes : synthèse de quinoléines, de l’échelle du laboratoire à l’échelle pilote." Thesis, Compiègne, 2014. http://www.theses.fr/2014COMP1909.

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Le glycérol, principal coproduit de l’industrie du biodiesel (10% massique), représente un solvant et un réactif d’un grand intérêt pour la chimie verte. La déshydratation du glycérol en acroléine est une voie intéressante pour sa valorisation. En effet, cet aldéhyde constitue une molécule plate-forme pour de nombreuses applications. En revanche, il s’agit d’un produit instable, toxique et inflammable, ce qui rend sa manipulation et sa manutention particulièrement dangereuses. Cette difficulté peut être surmontée par une transformation in-situ de l’acroléine formée par déshydratation du glycér

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35

Fantin, Creusa Aparecida. "Síntese e caracterização dos compostos de adição entre os mono e dicloroacetatos de lantanídeos (III) e a quinolina-N-óxido (QNO)." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/46/46134/tde-14032018-115520/.

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Este trabalho descreve a síntese e caracterização dos compostos de adição obtidos pela reação entre os monocloroacetatos (CA) e dicloroacetatos (DCA) de lantanídeos (III) com a quinolina-N-óxido (QNO), na presença de etanol e ortoformiato de trietila. Os compostos foram obtidos na forma sólida e caracterizados por análise elementar, testes de solubilidade, medidas de condutância eletrolítica, difração de raios X (método do pó), espectros de absorção na região do infravermelho, espectros de absorção na região do visível dos compostos de Nd, espectros de emissão dos compostos de Eu e análise tér

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36

LE, GOFF-BEVIERE CORINNE. "Pharmacomodulations de quinolones a structure benzo-ij-quinolizine : synthese et activite antibacterienne." Orléans, 1995. http://www.theses.fr/1995ORLE2019.

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L'objectif principal de notre travail sur la pharmacomodulation de quinolones nous a amenes a mettre au point de nouvelles strategies de synthese dans le domaine des quinoleines, a partir d'un synthon unique, la 6-fluoro-2-methylquinoleine conduisant aux precurseurs necessaires a la realisation des quinolones a structure benzoi,jquinolizine. Ainsi, l'utilisation des tetrahydroquinoleines-n-formylees nous a permis par des fonctionnalisations regioselectives d'atteindre des pharmacomodulations donnant acces aux heterocycles imidazo, thiazolo et oxazolo en position 4,5-g sur le noyau quinoleique.

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37

Aribi, Fallia. "Development and biological evaluation of novel fluorinated ingredients for modern crop protection." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF020.

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Ce doctorat a permis la conception de nouvelles molécules destinées aux développements de futurs produits phytosanitaires. Tout d’abord, la synthèse d’alpha,alpha-difluoro-beta-hydroxy cétones a été réalisée. Motif déjà reconnu dans le domaine pharmaceutique, nous voulions étendre son champ d’application à l’agrochimie. Une série de composés possédant une activité biologique en tant qu’agonistes des récepteurs GABA a été synthétisée. Ils ont été obtenus à l’issu d’une synthèse convergente nécessitant une réaction de couplage entre un aldéhyde aromatique et un intermédiaire alpha,alpha-difluoro

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38

Murphy, Steven Michael. "Novel aspects of the Wittig reaction." Thesis, Northumbria University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245286.

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Lu, Jianyu. "Syntheses of quinolines as neural protective reagents and progress towards total synthesis of (+) - myriceric acid A." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/27652.

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Doctor of Philosophy<br>Department of Chemistry<br>Duy H. Hua<br>The first chapter of this dissertation introduces and discusses the syntheses of a series of substituted quinolines as glycogen synthase kinase-3[beta] (GSK-3[beta]) inhibitors. GSK-3[beta] is highly associated with Alzheimer’s disease (AD), and it is suggested that inhibition of this enzyme could alleviate the symptoms of AD. Total 16 novel substituted quinolines were designed and synthesized, and their bio-activities were evaluated on MC65 cell protection assay. Four of the most active compounds were selected to test their enzy

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40

Benaissa, Tahar. "Synthèse de ligands contenant un atome de fluor et pouvant donner des complexes à applications médicales : étude de la complexation de la 5-fluoro-8-hydroxyquinoline avec des cations métalliques, par RMN du fluor." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10100.

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Ce travail se place a la convergence de deux grands themes etudies au laboratoire: le marquage de molecules par un atome de fluor et l'etude de la complexation de cations metalliques par des ligands. La premiere partie concerne la preparation de deux series de ligands contenant du fluor: des biphenols et des composes contenant des groupements 2-fluoropyridines. Les biphenols substitues par deux ou quatre atomes de fluor (en position 4,4' ; 5,5' ; 4,4 ;,5,5') ont ete obtenus a partir de bromophenols par une reaction de type ullman. Leurs derives sulfones ont egalement ete prepares pour augmente

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41

MacDonald, Alasdair Arthur. "Synthesis of quinolone antibiotics by Diversomer™ technology." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/11075.

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The generation of chemical diversity by the parallel synthesis of potential drug candidates has been demonstrated by Parke-Davis' DIVERSOMER Technology. This technology combines solid phase organic synthesis, (SPOS), miniaturization, automation, integration and custom equipment to generate "libraries" of discrete compounds. The research programme involved a detailed analysis of the synthesis of the quinolones, a well-known class of antibacterial agents of which over 6000 compounds are known to date. A solution phase synthesis was developed which was compatible with solid phase reaction conditi

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42

Hodgkinson, James Thomas. "The synthesis of Pseudomonas Quinolone Signal analogues and their effects on quinolone signalling in Pseudomonas aeruginosa." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610117.

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43

KO, DEN-YUAN, and 柯登淵. "Synthesis of Quinoline Derivatives of Curcumin." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/02939843223114971684.

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碩士<br>中國文化大學<br>化學系應用化學碩士班<br>104<br>Curcumin is isolated from the rhizome of Curcuma longa. Much evidence indicated that curcumin could be used as a therapeutic agent in the treatment of Alzheimer’s disease (AD) and could reduce the symptoms, including oxidative damage, inflammation, senile plaques, neurofibrillary tangles, cell cycle dysregulation and neuron damages. AD, a complex disease with multiple etiological factors, needs a multifunctional drug forits treatment. Curcumin is one of the potential drugs in the treatment of AD. Some quinolines are known as good metal chelating agents

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44

Teitgen, Alicen M. "Novel synthesis of quinoline-5,8-dione analogues." 2012. http://liblink.bsu.edu/uhtbin/catkey/1678996.

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The chemistry of quinonline-5,8-dione as a functional group is a developing field because of its various biological aspects. Lavendamycin and streptonigrin are known antibiotic, antitumor agents containing the quinolone-5,8-dione functional group believed to provide their antitumor properties. Most cancer cells show an elevated level of NQO1 enzyme which activates lavendamycin to act as an antitumor agent. The research goal is to explore different synthetic methods and reactions to produce novel quinolone-5,8-dione analogues with unique structural features while keeping the selective cytotoxic

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45

Hlungwani, Isaac. "Design, synthesis and biological evaluation of novel tetrasubstituted quinoline-3-carboxamides derivatives." Diss., 2020. http://hdl.handle.net/11602/1558.

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MSc (Chemistry)<br>Department of Chemistry<br>Quinolines are well known naturally occurring heterocyclic compounds with nitrogen as a heteroatom. Quinolines are also one of the major classes of naturally occurring compounds and the interest in their chemistry is due to the wide range of their biological activities. The objective of the project was the synthesis of novel tetra-substituted quinoline-3carboxamides and subsequent transformation to other novel derivatives and evaluation of their biological activities against malaria and cytotoxicity. In achieving the objective, 2-chloroquinoline-

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Lin, Bao-Jiun, and 林保君. "Synthesis and Biological Evaluation of Furo[3,2-h]quinoline and Furo[2,3-h]quinoline Derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/61262624727227638045.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>97<br>Certain aniline- or phenoxy-substituted furo[3,2-h]quinolin-8-yl, furo[2,3-h]quinolin-2-yl, and 7-prop-2-ynyloxyquinolin-2-yl derivatives were synthesized and evaluated for their anti-inflammatory activities. These compounds were synthesized via alkylation of hydroxyl precursors followed by the chlorination, cyclization, and reaction with appropriate Ar-NH2 or Ar-OH. Anti- inflammatory activities of these quinoline derivatives were evaluated on the suppression of reactive oxygen species (ROS) production induced by formyl-methionyl-leucyl-phenylalanine (fMLP, 1

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Tai-Chi, Wang, and 王泰吉. "Synthesis And Biological Activity Evaluation of Quinoline And Quinolin-2(1H)-one a-Methylene-g-butyrolactones." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/87526227498769038220.

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博士<br>高雄醫學院<br>藥學研究所<br>87<br>The quinoline and quinolin-2(1H)-one a-methylene-g-butyrolactones were synthesized from hydroxyquinoline and hydroxyquinolin-2(1H)-one via alkylation and Reformatsky-type condensation. The key precursors of hydroxyquinolin-2(1H)-ones were prepared from methoxyanilines and cinnamoyl chloride to give the respective methoxycinnamanilides. Their cyclization with aluminum chloride in chlorobenzene at 120°C afforded the desired intramolecular Friedel-Crafts cyclization products of hydroxy- quinolin-2(1H)-ones in good overall yield. To o

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RAHUL, SUBHASH TALEKAR. "Design,Synthesis and Biological Evaluation of Quinoline Analogues." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0407200615584300.

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Mkhize, Zimbili. "Studies towards the synthesis of perhydropyrrolo[2,1-j]quinoline and perhydropyrido[2,1-j]quinoline ascidian alkaloids." Thesis, 2002. http://hdl.handle.net/10413/3725.

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Cylindricines A-K [1-11], lepadifonnine [12] and fasicularin [13] are tricyclic ascidian alkaloids exhibiting the perhydropyrrolo[2,1 :j]quinoline and perhydropyrido[2,1-j]quinoline ring systems. The structural features and biological activity of these alkaloids make them ideal targets for total synthesis. The first aim of this project was to construct the azabicycles [111] and [112] that resemble the spirocyclic core of these alkaloids. The synthesis began with the C ring intact and the attempted construction of the B ring using Diels-Alder methodology. A key step was the Eschenmoser couplin

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Lo, Wei Fen, and 羅偉棻. "Synthesis and anticancer evaluation of 4-anilinofuro[2,3-b]quinoline and 4-anilinofuro[3,2-c]quinoline derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/fyfqj3.

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博士<br>高雄醫學大學<br>醫藥暨應用化學系博士班<br>103<br>Certain furo[2,3-b]quinoline and furo[3,2-c]quinoline derivatives have been synthesized and evaluated for their antiproliferative activities. Among them, CIL-102 was found to be the most potent. However, it exhibited general cytotoxicity to most of cancers and normal cells. In addition, it displayed other drawbacks such as low oral availability and poor aqueous solubility. In order to improve these drawbacks, we optimized the chemical structure of CIL-102 to settle these problems. CIL-102 is active against the growth of PC-3、A549, MCF-7 and M-10 cells with

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