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1

Szablowski, Jerzy O., Joon Pyung Seo, Sangsin Lee, et al. "Monitoring gene expression in the brain with synthetic serum markers." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A22. http://dx.doi.org/10.1121/10.0026652.

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Blood tests are among the most common clinical tools due to their low cost, simplicity, and ability to observe many markers at once. However, currently, blood tests can only monitor a fraction of physiological processes that happen to have a serum marker. Here, we will present our work on the development of synthetic serum markers that can track gene expression in intact brain cells with a simple blood test. The synthetic marker approach has several advantages. First, detection of existing markers may be challenging due to their low levels in blood. With a synthetic marker, one can design a re
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2

Lozano-Ramírez, Nerida, Susanne Dreisigacker, Carolina P. Sansaloni, et al. "Genome-Wide Association Study for Resistance to Tan Spot in Synthetic Hexaploid Wheat." Plants 11, no. 3 (2022): 433. http://dx.doi.org/10.3390/plants11030433.

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Synthetic hexaploid wheat (SHW) has shown effective resistance to a diversity of diseases and insects, including tan spot, which is caused by Pyrenophora tritici-repentis, being an important foliar disease that can attack all types of wheat and several grasses. In this study, 443 SHW plants were evaluated for their resistance to tan spot under controlled environmental conditions. Additionally, a genome-wide association study was conducted by genotyping all entries with the DArTSeq technology to identify marker-trait associations for tan spot resistance. Of the 443 SHW plants, 233 showed resist
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3

Sorrells, Mark E., J. Perry Gustafson, Daryl Somers, et al. "Reconstruction of the Synthetic W7984 × Opata M85 wheat reference population." Genome 54, no. 11 (2011): 875–82. http://dx.doi.org/10.1139/g11-054.

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Reference populations are valuable resources in genetics studies for determining marker order, marker selection, trait mapping, construction of large-insert libraries, cross-referencing marker platforms, and genome sequencing. Reference populations can be propagated indefinitely, they are polymorphic and have normal segregation. Described are two new reference populations who share the same parents of the original wheat reference population Synthetic W7984 (Altar84/ Aegilops tauschii (219) CIGM86.940) × Opata M85, an F1-derived doubled haploid population (SynOpDH) of 215 inbred lines and a rec
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Chimsook, Thitiphan. "Synthesis and Properties of Barakol Tailored for Fluorescent Biodiesel Marker." Applied Mechanics and Materials 490-491 (January 2014): 168–71. http://dx.doi.org/10.4028/www.scientific.net/amm.490-491.168.

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This work reports the synthesis and evaluation of barakol tailored to become biodiesel fluorescent markers. Fluorescent markers for biodiesel fuels were synthesized from the reaction between barakol, which was obtained from the leaves and flowers ofCassia siameLamk., with acid chloride in the presence of triethylamine. These synthetic fluorescent markers were 7-lauroyloxy-5-acetonyl-2-methylchromone, 7-butyryloxy-5-acetonyl-2-methylchromone and 7-(2-ethyl)-hexanoyloxy-5-acetonyl-2-methylchromone. These synthetic fluorescent markers were invisible color in biodiesel fuels when they were added i
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Zhao, Hao‐Qian, Wen‐Qing Wei, Chao Zhao, and Ze‐Xiong Xie. "Genomic markers on synthetic genomes." Engineering in Life Sciences 21, no. 12 (2021): 825–31. http://dx.doi.org/10.1002/elsc.202100030.

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6

Vadas, Evelin, Antonio J. López-Gambero, Antonio Vargas, et al. "Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus." Biomolecules 15, no. 3 (2025): 417. https://doi.org/10.3390/biom15030417.

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Synthetic cannabinoid use raises concerns about its neuroinflammatory effects, including molecular adaptations of the endocannabinoid system (ECS) in the brain. This study investigates the pharmacological effects of 14-day repeated intraperitoneal administration, as well as 14-day administration followed by a 7-day withdrawal period of two synthetic cannabinoids: WIN55,212-2 and HU-210. The study assessed gene expression and protein markers related to the ECS, gliosis, and inflammation in two brain regions critical for cognitive processes and memory—key components of addiction pathways—the pre
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7

Sood, Meemansa, Ulrike Suenkel, Anna-Katharina von Thaler, et al. "Bayesian network modeling of risk and prodromal markers of Parkinson’s disease." PLOS ONE 18, no. 2 (2023): e0280609. http://dx.doi.org/10.1371/journal.pone.0280609.

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Parkinson’s disease (PD) is characterized by a long prodromal phase with a multitude of markers indicating an increased PD risk prior to clinical diagnosis based on motor symptoms. Current PD prediction models do not consider interdependencies of single predictors, lack differentiation by subtypes of prodromal PD, and may be limited and potentially biased by confounding factors, unspecific assessment methods and restricted access to comprehensive marker data of prospective cohorts. We used prospective data of 18 established risk and prodromal markers of PD in 1178 healthy, PD-free individuals
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8

Farrakh, Sumaira, Sumbul Khalid, Ayesha Rafique, Naveeda Riaz, and Abdul Mujeeb-Kazi. "Identification of stripe rust resistant genes in resistant synthetic hexaploid wheat accessions using linked markers." Plant Genetic Resources 14, no. 3 (2015): 219–25. http://dx.doi.org/10.1017/s1479262115000283.

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Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most important diseases affecting wheat. In this study, seven gene-linked markers were used to identify the presence of stripe rust resistant genes in 51 accessions of synthetic hexaploid of wheat which were found to be resistant at seedling plant stage. Molecular marker-based gene identification showed the presence of Yr5, Yr10 and Yr15 in three accessions, Yr36 in three accessions, Yr48 in seven accessions, YrR61 in four accessions, and YrTP1 in ten accessions of resistant hexaploid of wheat. These gene-linked ma
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9

Kyle, Patrick B., and Jaswinder Kaur. "Evaluating Novel Markers for Specimen Validity Testing." Archives of Pathology & Laboratory Medicine 144, no. 2 (2019): 168–71. http://dx.doi.org/10.5858/arpa.2019-0197-oa.

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Context.— Synthetic urine products are commercially marketed for the purpose of specimen substitution for urine drug screens. These products are widely popular because they yield negative drug screen results, meet criteria for specimen validity testing, and are easily accessible and affordable. Current specimen validity criteria are ineffective for detecting these synthetic products, and new markers of specimen validity are required. Objective.— To develop and evaluate a multicomponent liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for urine specimen validity testing. Design.—
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10

Gálico, Diogo A., Jeffrey S. Ovens, and Muralee Murugesu. "NIR-to-NIR emission on a water-soluble {Er6} and {Er3Yb3} nanosized molecular wheel." Nanoscale 12, no. 21 (2020): 11435–39. http://dx.doi.org/10.1039/d0nr02236e.

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Lanthanide molecular clusters as near-infrared markers are highly tunable owing to the bottom-up synthetic approach. Facile synthesis, high crystallinity, water stability are all highly desirable attributes of clusters for biological and telecommunications technology.
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11

Desai, Sonal, and Pratima Tatke. "Phytochemical Markers: Classification, Applications and Isolation." Current Pharmaceutical Design 25, no. 22 (2019): 2491–98. http://dx.doi.org/10.2174/1381612825666190709203239.

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Background: There has been aroused demand for herbal drugs/products worldwide because of their fewer side effects as compared to synthetic drugs. The major obstacle in the global acceptance of herbal products is the lack of proper standardization technique. Methods: Various test procedures have been used for authentication and quality control of botanicals among which marker based standardization has attained more attention. The major challenge faced by phytochemist is to select appropriate phytochemical marker for quality control of herbal drugs. Phytochemical markers used for standardization
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12

Lee, Jeong Hee, Seok Tae Choi, and Young Jin Kang. "Kahweol, a Diterpenoid Molecule, Inhibits CTGF-Dependent Synthetic Phenotype Switching and Migration in Vascular Smooth Muscle Cells." Molecules 26, no. 3 (2021): 640. http://dx.doi.org/10.3390/molecules26030640.

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Vascular smooth muscle cell (VSMC) phenotype switching from contractile to synthetic is essential for proliferation and migration in vascular pathophysiology. Connective tissue growth factor (CTGF) is a matricellular protein involved in cell adhesion, migration, and proliferation. Kahweol, a diterpene molecule in arabica coffee beans, has been reported to have anti-inflammatory, antiproliferative, and apoptotic effects in many cells. However, in VSMCs, the effects of kahweol on CTGF activities have not been investigated. Thus, in this study, the effects and associated mechanisms of kahweol in
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13

Lin, Chin-Sheng, Po-Shiuan Hsieh, Ling-Ling Hwang, et al. "The CCL5/CCR5 Axis Promotes Vascular Smooth Muscle Cell Proliferation and Atherogenic Phenotype Switching." Cellular Physiology and Biochemistry 47, no. 2 (2018): 707–20. http://dx.doi.org/10.1159/000490024.

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Background/Aims: Hyperlipidemia induces dysfunction in the smooth muscle cells (SMCs) of the blood vessels, and the vascular remodeling that ensues is a key proatherogenic factor contributing to cardiovascular events. Chemokines and chemokine receptors play crucial roles in vascular remodeling. Here, we examined whether the hyperlipidemia-derived chemokine CCL5 and its receptor CCR5 influence vascular SMC proliferation, phenotypic switching, and explored the underlying mechanisms. Methods: Thoracoabdominal aorta were isolated from wild-type, CCL5 and CCR5 double-knockout mice (CCL5–/–CCR5–/–)
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14

Čejka, Jan, Fabio Bruno, Dimitrios Skarlatos, and Fotis Liarokapis. "Detecting Square Markers in Underwater Environments." Remote Sensing 11, no. 4 (2019): 459. http://dx.doi.org/10.3390/rs11040459.

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Augmented reality can be deployed in various application domains, such as enhancing human vision, manufacturing, medicine, military, entertainment, and archeology. One of the least explored areas is the underwater environment. The main benefit of augmented reality in these environments is that it can help divers navigate to points of interest or present interesting information about archaeological and touristic sites (e.g., ruins of buildings, shipwrecks). However, the harsh sea environment affects computer vision algorithms and complicates the detection of objects, which is essential for augm
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15

Micklem, Kingsley J. "Novel leukaemia markers." Bioscience Reports 15, no. 6 (1995): 463–68. http://dx.doi.org/10.1007/bf01204349.

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Using synthetic peptide or recombinant protein as immunising antigens we have produced monoclonal antibodies and polyclonal antisera directed against targets of particular interest in leukaemia diagnosis. In this way we have prepared reagents which recognise all T or all B lymphocytes in routinely fixed paraffin sections which are unique in this respect. We have also produced monoclonal antibodies to molecules potentially involved in specific neoplastic transformations, implicated by virtue of the involvement of their genes in chromosomal defects in these neoplasms. In particular, we have prod
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16

Kim, Gyu-Tae, Ulrike Waizmann, and Siegmar Roth. "Simple efficient coordinate markers for investigating synthetic nanofibers." Applied Physics Letters 79, no. 21 (2001): 3497–99. http://dx.doi.org/10.1063/1.1419054.

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17

Kent, Jack W. "Rare variants, common markers: synthetic association and beyond." Genetic Epidemiology 35, S1 (2011): S80—S84. http://dx.doi.org/10.1002/gepi.20655.

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18

Ondrašovič, Milan, and Peter Tarábek. "Homography Ranking Based on Multiple Groups of Point Correspondences." Sensors 21, no. 17 (2021): 5752. http://dx.doi.org/10.3390/s21175752.

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Homography mapping is often exploited to remove perspective distortion in images and can be estimated using point correspondences of a known object (marker). We focus on scenarios with multiple markers placed on the same plane if their relative positions in the world are unknown, causing an indeterminate point correspondence. Existing approaches may only estimate an isolated homography for each marker and cannot determine which homography achieves the best reprojection over the entire image. We thus propose a method to rank isolated homographies obtained from multiple distinct markers to selec
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19

Melnikova, Nataliya V., Fedor A. Konovalov, and Alexander M. Kudryavtsev. "Long terminal repeat retrotransposon Jeli provides multiple genetic markers for common wheat (Triticum aestivum)." Plant Genetic Resources 9, no. 2 (2011): 163–65. http://dx.doi.org/10.1017/s1479262111000487.

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The recombinant inbred line mapping population Opata85 × Synthetic W7984 was used to map Jeli long terminal repeat retrotransposon insertion sites in the hexaploid wheat genome. Sequence-specific amplified polymorphism technique was applied to reveal Jeli insertions. Jeli was found to provide multiple genetic markers for common wheat. Our marker system revealed A-genome Jeli insertions, and therefore can be used for targeted analysis of the A genome.
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20

Zhang, Ruiqi, Ravi P. Singh, Morten Lillemo, et al. "Two Main Stripe Rust Resistance Genes Identified in Synthetic-Derived Wheat Line Soru#1." Phytopathology® 109, no. 1 (2019): 120–26. http://dx.doi.org/10.1094/phyto-04-18-0141-r.

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Stripe rust is a major disease constraint of wheat production worldwide. Resistance to stripe rust was analyzed using 131 F6 recombinant inbred lines (RILs) derived from a cross between synthetic derived wheat line Soru#1 and wheat cultivar Naxos. The phenotype was evaluated in Mexico and Norway at both seedling and adult plant stages. Linkage groups were constructed based on 90K single-nucleotide polymorphism (SNP), sequence-tagged site, and simple sequence repeat markers. Two major resistance loci conferred by Soru#1 were detected and located on chromosomes 1BL and 4DS. The 1BL quantitative
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21

Dosoky, Noura S., Ambika Poudel, and Prabodh Satyal. "Authentication and Market Survey of Sweet Birch (Betula lenta L.) Essential Oil." Plants 11, no. 16 (2022): 2132. http://dx.doi.org/10.3390/plants11162132.

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Sweet Birch (Betula lenta) has several economic and medicinal uses. Very little is known about the chemical composition of B. lenta. In this study, the volatile compositions of the bark of B. lenta from authentic and commercial sources were assessed by gas chromatography-mass spectrometry (GC–MS) and gas chromatography–flame ionization detection (GC–FID). Overall, more than 60 compounds were identified in natural sweet birch EO obtained by hydro-distillation. The oil was dominated by methyl salicylate (93.24–99.84%). A good approach to distinguishing wintergreen and birch oils would be biomark
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22

Lozano-Ramirez, Nerida, Susanne Dreisigacker, Carolina P. Sansaloni, et al. "Genome-Wide Association Study for Spot Blotch Resistance in Synthetic Hexaploid Wheat." Genes 13, no. 8 (2022): 1387. http://dx.doi.org/10.3390/genes13081387.

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Spot blotch (SB) caused by Bipolaris sorokiniana (Sacc.) Shoem is a destructive fungal disease affecting wheat and many other crops. Synthetic hexaploid wheat (SHW) offers opportunities to explore new resistance genes for SB for introgression into elite bread wheat. The objectives of our study were to evaluate a collection of 441 SHWs for resistance to SB and to identify potential new genomic regions associated with the disease. The panel exhibited high SB resistance, with 250 accessions showing resistance and 161 showing moderate resistance reactions. A genome-wide association study (GWAS) re
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23

Siegel, Jeff, Benedikt Szmrecsanyi, and Bernd Kortmann. "Measuring analyticity and syntheticity in creoles." Journal of Pidgin and Creole Languages 29, no. 1 (2014): 49–85. http://dx.doi.org/10.1075/jpcl.29.1.02sie.

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Creoles (here including expanded pidgins) are commonly viewed as being more analytic than their lexifiers and other languages in terms of grammatical marking. The purpose of the study reported in this article was to examine the validity of this view by measuring the frequency of analytic (and synthetic) markers in corpora of two different English-lexified creoles — Tok Pisin and Hawai‘i Creole — and comparing the quantitative results with those for other language varieties. To measure token frequency, 1,000 randomly selected words in each creole corpus were tagged with regard to word class, an
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24

Ignjatovic-Micic, Dragana, Ksenija Markovic, and Vesna Lazic-Jancic. "Application of molecular markers in bulk segragant analysis of yield in maize (Zea mays L) synthetic populations." Genetika 38, no. 1 (2006): 59–66. http://dx.doi.org/10.2298/gensr0601059i.

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Chromosome regions which carry potential QTLs for high grain yield in two synthetic maize populations - B73xMol7 and LlxMol7, were identified by bulk segregant analysis (BSA). Yield was evaluated on F2 testcross families in field trials using a Nested design. Based on yield data, p3 families with the corresponding highest and lowest testcross yields were selected for BSA. Genome analysis of F3 families was carried out with 58 RFLP markers. Allele frequency differences were detected at four RFLP loci n chromosomes 1, 2, 6 and 10 (B73xMol7), i.e. four RFLP loci on chromosomes 1, 2, 6 and 9 (LlxM
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Sankar, Muthu, Binod Kumar, Haranahally Vasanthachar Manjunathachar, et al. "Genetic Diversity of Rhipicephalus (Boophilus) microplus for a Global Scenario: A Comprehensive Review." Pathogens 13, no. 6 (2024): 516. http://dx.doi.org/10.3390/pathogens13060516.

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Rhipicephalus microplus poses a substantial threat to livestock health and agricultural economies worldwide. Its remarkable adaptability to diverse environments and hosts is a testament to its extensive genetic diversity. This review delves into the genetic diversity of R. microplus, employing three pivotal genetic markers: the cytochrome c oxidase I (COX1) gene, ribosomal genes, and microsatellites. The COX1 gene, a crucial tool for genetic characterization and phylogenetic clustering, provides insights into the adaptability of ticks. Ribosomal genes, such as internal transcribed spacer regio
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26

Adhikari, Tika B., Joseph M. Anderson, and Stephen B. Goodwin. "Identification and Molecular Mapping of a Gene in Wheat Conferring Resistance to Mycosphaerella graminicola." Phytopathology® 93, no. 9 (2003): 1158–64. http://dx.doi.org/10.1094/phyto.2003.93.9.1158.

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Septoria tritici leaf blotch (STB), caused by the ascomycete Mycosphaerella graminicola (anamorph Septoria tritici), is an economically important disease of wheat. Breeding for resistance to STB is the most effective means to control this disease and can be facilitated through the use of molecular markers. However, molecular markers linked to most genes for resistance to STB are not yet available. This study was conducted to test for resistance in the parents of a standard wheat mapping population and to map any resistance genes identified. The population consisted of 130 F10 recombinant-inbre
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27

McIntyre, C. L., A. Rattey, A. Kilian, M. F. Dreccer, and R. Shorter. "Preferential retention of chromosome regions in derived synthetic wheat lines: a source of novel alleles for wheat improvement." Crop and Pasture Science 65, no. 2 (2014): 125. http://dx.doi.org/10.1071/cp13153.

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Synthetic hexaploid wheats (SHWs) and their synthetic derivative lines (SDLs) are being used as a means of introducing novel genetic variation into bread wheat (BW). Phenotypic information for days to flowering, height, grain weight and grain yield was collected from multiple environments for three SDL families, each with ~50 lines, and their elite BW parents. In general, the SDLs were earlier flowering and taller with larger grain size, but similar grain yield to the BWs. The three SDL families and their SHW and BW parents were genotyped using mapped DArT (diversity arrays technology) markers
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28

McGrath, J. Mitchell, and Carlos F. Quiros. "Generation of alien chromosome addition lines from synthetic Brassica napus: morphology, cytology, fertility, and chromosome transmission." Genome 33, no. 3 (1990): 374–83. http://dx.doi.org/10.1139/g90-057.

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The chromosome complement of Brassica oleracea (2n = 18) was dissected by means of alien chromosome addition lines generated by successive backcrosses of either of two B. campestris accessions (2n = 20) to the resynthesized B. napus 'Hakuran' (2n = 38). Alien chromosome addition lines were characterized by chromosome counts, morphology, pollen and seed fertility, and transmission of chromosome-specific markers. Mean chromosome number in the first backcross generation was approximately 23.5 and was little influenced by the B. campestris accession. Fertility and isozyme marker transmission were
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Ito, Shosuke, Sandra Del Bino, Tomohisa Hirobe, and Kazumasa Wakamatsu. "Improved HPLC Conditions to Determine Eumelanin and Pheomelanin Contents in Biological Samples Using an Ion Pair Reagent." International Journal of Molecular Sciences 21, no. 14 (2020): 5134. http://dx.doi.org/10.3390/ijms21145134.

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Alkaline hydrogen peroxide oxidation (AHPO) of eumelanin and pheomelanin, two major classes of melanin pigments, affords pyrrole-2,3,5-tricarboxylic acid (PTCA), pyrrole-2,3-dicarboxylic acid (PDCA) and pyrrole-2,3,4,5-tetracarboxylic acid (PTeCA) from eumelanin and thiazole-2,4,5-tricarboxylic acid (TTCA) and thiazole-4,5-dicarboxylic acid (TDCA) from pheomelanin. Quantification of these five markers by HPLC provides useful information on the quantity and structural diversity of melanins in various biological samples. HPLC analysis of these markers using the original method of 0.1 M potassium
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Zwart, R. S., J. P. Thompson, and I. D. Godwin. "Identification of quantitative trait loci for resistance to two species of root-lesion nematode (Pratylenchus thornei and P. neglectus) in wheat." Australian Journal of Agricultural Research 56, no. 4 (2005): 345. http://dx.doi.org/10.1071/ar04223.

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Pratylenchus thornei and P. neglectus are two species of root-lesion nematode that cause substantial yield losses in wheat. No commercially available wheat variety has resistance to both species. A doubled-haploid population developed from a cross between the synthetic hexaploid wheat line CPI133872 and the bread wheat Janz was used to locate and tag quantitative trait loci (QTLs) associated with resistance to both P. thornei and P. neglectus. Wheat plants were inoculated with both species of nematode in independent replicated glasshouse trials repeated over 2 years. Known locations of wheat m
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Freudenberg, Robert A., Luisa Wittemeier, Alexander Einhaus, Thomas Baier, and Olaf Kruse. "The Spermidine Synthase Gene SPD1: A Novel Auxotrophic Marker for Chlamydomonas reinhardtii Designed by Enhanced CRISPR/Cas9 Gene Editing." Cells 11, no. 5 (2022): 837. http://dx.doi.org/10.3390/cells11050837.

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Biotechnological application of the green microalga Chlamydomonas reinhardtii hinges on the availability of selectable markers for effective expression of multiple transgenes. However, biological safety concerns limit the establishment of new antibiotic resistance genes and until today, only a few auxotrophic markers exist for C. reinhardtii. The recent improvements in gene editing via CRISPR/Cas allow directed exploration of new endogenous selectable markers. Since editing frequencies remain comparably low, a Cas9-sgRNA ribonucleoprotein (RNP) delivery protocol was strategically optimized by
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Upadhyay, Sweta, Sanjay Gupta, Vijay Kumar, and Anjali Uniyal. "In vitro propagation, synthetic seeds production and clonal fidelity assessment of regenerants of endangered herb Rheum emodi." Research Journal of Biotechnology 19, no. 12 (2024): 70–78. https://doi.org/10.25303/1912rjbt070078.

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Rheum emodi, pharmaceutically important medicinal plant is mainly found in northern Himalayas. This herb has therapeutic properties such as anticancerous, antimicrobial, behaves like astringent and improves gastro related problems. All these factors contribute in immense decline of this herb in its natural habitat as it is excessively used by local people for medicinal as well as common eating purpose. We have optimized the efficient in vitro plant regeneration system through the callus from leaf explant and synthetic seed production for this herb. The culture medium used was Murashige and Sko
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Capetti, Francesca, Arianna Marengo, Cecilia Cagliero, et al. "Adulteration of Essential Oils: A Multitask Issue for Quality Control. Three Case Studies: Lavandula angustifolia Mill., Citrus limon (L.) Osbeck and Melaleuca alternifolia (Maiden & Betche) Cheel." Molecules 26, no. 18 (2021): 5610. http://dx.doi.org/10.3390/molecules26185610.

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The quality control of essential oils (EO) principally aims at revealing the presence of adulterations and at quantifying compounds that are limited by law by evaluating EO chemical compositions, usually in terms of the normalised relative abundance of selected markers, for comparison to reference values reported in pharmacopoeias and/or international norms. Common adulterations of EO consist of the addition of cheaper EO or synthetic materials. This adulteration can be detected by calculating the percent normalised areas of selected markers or the enantiomeric composition of chiral components
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Koshy, Anish. "Re-evaluating Affixes and Clitics in Munda Multi-verb Constructions." Indian Journal of Language and Linguistics 5, no. 3 (2024): 62–75. http://dx.doi.org/10.54392/ijll2436.

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Languages from the same genetic lineage often exhibit differences in certain parameters, but significant variation in their morphological typology is uncommon. Austroasiatic languages present a notable paradox, where Munda languages are categorized as polysynthetic, while Mon-Khmer languages are considered isolating. This contrast within the same linguistic family, with both sub-branches occupying opposite ends of the synthesis continuum, is particularly intriguing. This paper aims to explore whether the morphological disparity between Munda and Mon-Khmer languages can be reconciled by examini
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Longinotti, Gloria, Gabriel Ybarra, Susana Vighi, et al. "One Step Histological Detection and Staining of the PTEN Tumor Suppressor Protein by a Single Strand DNA." Diagnostics 11, no. 2 (2021): 171. http://dx.doi.org/10.3390/diagnostics11020171.

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Antibodies are the most used technological tool in histochemistry. However, even with monoclonal antibodies, their standardization is difficult due to variation of biological systems as well as to variability due to the affinity and amplification of the signal arising from secondary peroxidase detection systems. In this article we combined two synthetic molecules to facilitate the standardization of a detection protocol of protein markers in histological sections. The first molecule was an aptamer, a 50-base single-stranded DNA fragment, which recognizes a PTEN tumor suppressor. The second mol
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Wen, Juan, Baiyi Tang, Lan Guo, Wei Chen, and Xiaohong Tang. "miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding." International Journal of Hypertension 2023 (July 20, 2023): 1–14. http://dx.doi.org/10.1155/2023/9497716.

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It has been shown that miR-145 is involved in the differentiation of vascular smooth muscle cells (VSMCs) and may regulate vascular remodeling. However, the molecular mechanisms behind these pathological processes in hypertension are not fully elucidated. The present study was to examine whether miR-145 modulates phenotypic transformation of VSMCs under normal state and synthetic state and to explore the possible role of ADAM17-mediated ACE2 shedding and ACE2-Ang-(1–7)-Mas receptor axis. Wistar rats were fed with high-sucrose/high-fat diet for 30 weeks to establish a metabolic hypertension ani
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37

Babayeva, M., A. Kerimov, S. Mamedova, and Z. Akperov. "Study of synthetic wheat genotypes based on prolamine protein markers." Science and Innovations 1, no. 12 (2024): 68–72. http://dx.doi.org/10.29235/1818-9857-2023-12-68-72.

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38

BAI, X. "A55 CHRONIC STRESS IMPAIRS THE INTESTINAL CRYPTAL STEM CELL CYCLE AND PANETH CELL PROLIFERATION." Journal of the Canadian Association of Gastroenterology 8, Supplement_1 (2025): i22—i23. https://doi.org/10.1093/jcag/gwae059.055.

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Abstract Background The small intestine’s epithelial barrier is essential for intestinal homeostasis and host defense. It consists of epithelial cells constantly renewed by crypt stem cells and their progeny, which have different functions in the gut. Chronic stress can impair the barrier by modulating the gut-brain axis, which involves the hypothalamic-pituitary-adrenal (HPA) axis, the vagus nerve, and the immune system. Chronic stress can also alter the gut microbiota, further influencing the barrier and immune system. Aims The present study examines how chronic stress affects the crypt stem
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39

Southwood, O. I., S. Hoste, T. H. Short, A. J. Mileham, and D. Cuthbert-Heavens. "Evaluation of genetic markers for litter size in Meishan synthetic and Large White pigs." Proceedings of the British Society of Animal Science 1996 (March 1996): 18. http://dx.doi.org/10.1017/s1752756200592229.

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A significant relationship between the oestrogen receptor gene (ESR) and litter size has been detected in USA populations of Large White and a synthetic comprising 50% Meishan (Rothschild et al., 1995). Animals carrying two copies of the favourable allele (B) had an extra pig born per litter than those that did not have the allele. This paper reports on results observed in a UK 50% Meishan synthetic and four UK Large White lines.Litter size data from 50% Meishan synthetic (L93) full-sib females where more than one ESR genotype was segregating. Data were analysed using a mixed model with full r
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40

Southwood, O. I., S. Hoste, T. H. Short, A. J. Mileham, and D. Cuthbert-Heavens. "Evaluation of genetic markers for litter size in Meishan synthetic and Large White pigs." Proceedings of the British Society of Animal Science 1996 (March 1996): 18. http://dx.doi.org/10.1017/s0308229600029937.

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A significant relationship between the oestrogen receptor gene (ESR) and litter size has been detected in USA populations of Large White and a synthetic comprising 50% Meishan (Rothschild et al., 1995). Animals carrying two copies of the favourable allele (B) had an extra pig born per litter than those that did not have the allele. This paper reports on results observed in a UK 50% Meishan synthetic and four UK Large White lines.Litter size data from 50% Meishan synthetic (L93) full-sib females where more than one ESR genotype was segregating. Data were analysed using a mixed model with full r
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41

Jani, Mehul, and Rajeev K. Azad. "IslandCafe: Compositional Anomaly and Feature Enrichment Assessment for Delineation of Genomic Islands." G3: Genes|Genomes|Genetics 9, no. 10 (2019): 3273–85. http://dx.doi.org/10.1534/g3.119.400562.

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One of the evolutionary forces driving bacterial genome evolution is the acquisition of clusters of genes through horizontal gene transfer (HGT). These genomic islands may confer adaptive advantages to the recipient bacteria, such as, the ability to thwart antibiotics, become virulent or hypervirulent, or acquire novel metabolic traits. Methods for detecting genomic islands either search for markers or features typical of islands or examine anomaly in oligonucleotide composition against the genome background. The former tends to underestimate, missing islands that have the markers either lost
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42

Maisak, Timur. "Endoclitics in Andi." Folia Linguistica 55, no. 1 (2021): 1–34. http://dx.doi.org/10.1515/flin-2020-2069.

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Abstract The paper provides evidence for the existence of endoclitics in Andi, a Nakh-Daghestanian language of the Avar-Andic branch spoken in the Republic of Daghestan, Russia. In Andi, the additive marker (‘also’) and the intensifying marker (‘even, at all’) behave as enclitics on various types of hosts and as endoclitics when they occur on negative verb forms. In the latter case, the additive and intensifying markers break up the word form and appear before the negation marker. I argue that both the additive and the intensifier are clitics, especially in view of their highly promiscuous att
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43

Furmanik, Malgorzata, Martijn Chatrou, Rick van Gorp, et al. "Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification." Circulation Research 127, no. 7 (2020): 911–27. http://dx.doi.org/10.1161/circresaha.119.316159.

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Rationale: Vascular calcification, the formation of calcium phosphate crystals in the vessel wall, is mediated by vascular smooth muscle cells (VSMCs). However, the underlying molecular mechanisms remain elusive, precluding mechanism-based therapies. Objective: Phenotypic switching denotes a loss of contractile proteins and an increase in migration and proliferation, whereby VSMCs are termed synthetic. We examined how VSMC phenotypic switching influences vascular calcification and the possible role of the uniquely calcium-dependent reactive oxygen species (ROS)-forming Nox5 (NADPH oxidase 5).
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Khalid, Maria, Alvina Gul, Rabia Amir, et al. "QTL mapping for seedling morphology under drought stress in wheat cross synthetic (W7984)/Opata." Plant Genetic Resources: Characterization and Utilization 16, no. 4 (2018): 359–66. http://dx.doi.org/10.1017/s1479262118000023.

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AbstractDrought stress ‘particularly at seedling stage’ causes morpho-physiological differences in wheat which are crucial for its survival and adaptability. In the present study, 209 recombinant inbred lines (RILs) from synthetic wheat (W7984)× ‘Opata’ (also known as SynOpRIL) population were investigated under well-watered and water-limited conditions to identify quantitative trait loci (QTL) for morphological traits at seedling stage. Analysis of variance revealed significant differences (P < 0.01) among RILs, and water treatments for all traits with moderate to high broad sense heritabi
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Molfetta, Matteo Gianluca, Maria Francesca Bruno, Luigi Pratola, et al. "A Sterescopic System to Measure Water Waves in Laboratories." Remote Sensing 12, no. 14 (2020): 2288. http://dx.doi.org/10.3390/rs12142288.

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A new system for estimating the synthetic parameters of sea states during physical investigations has been implemented. The technique proposed herein is based on stereographic analysis of digital images acquired with optical sensors. A series of ad hoc floating markers has been made and properly moored to the bottom of a large wave tank to estimate the synthetic parameters of generated waves. The implemented acquisition system and the proposed algorithm provide automatic recognition of all markers by a pair of optical sensors that synchronously captures their instantaneous location and tracks
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Yamada, Yohko, Mari Maeda, Mohamed Mahdi Alshahni, Michel Monod, Peter Staib, and Tsuyoshi Yamada. "Flippase (FLP) recombinase-mediated marker recycling in the dermatophyte Arthroderma vanbreuseghemii." Microbiology 160, no. 10 (2014): 2122–35. http://dx.doi.org/10.1099/mic.0.076562-0.

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Biological processes can be elucidated by investigating complex networks of relevant factors and genes. However, this is not possible in species for which dominant selectable markers for genetic studies are unavailable. To overcome the limitation in selectable markers for the dermatophyte Arthroderma vanbreuseghemii (anamorph: Trichophyton mentagrophytes), we adapted the flippase (FLP) recombinase-recombination target (FRT) site-specific recombination system from the yeast Saccharomyces cerevisiae as a selectable marker recycling system for this fungus. Taking into account practical applicabil
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47

Farman, M. L., and S. A. Leong. "Genetic and physical mapping of telomeres in the rice blast fungus, Magnaporthe grisea." Genetics 140, no. 2 (1995): 479–92. http://dx.doi.org/10.1093/genetics/140.2.479.

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Abstract Telomeric restriction fragments were genetically mapped to a previously described linkage map of Magnaporthe grisea, using RFLPs identified by a synthetic probe. (TTAGGG)3. Frequent rearrangement of telomeric sequences was observed in progeny isolates creating a potential for misinterpretation of data. Therefore a consensus segregation data set used to minimize mapping errors. TWelve of the 14 telomeres were found to be genetically linked to existing RFLP markers. Second-dimensional electrophoresis of restricted chromosomes confirmed these linkage assignments and revealed the chromoso
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48

Gupta, Arvind K., Deepak Pardasani, Hemendra K. Gupta, and Devendra K. Dubey. "N,N′-Dichlorobis(2,4,6-trichlorophenyl)urea (CC-2): an Efficient Reagent for the Synthesis of Chemical Weapons Convention-Related Dialkyl-N,N-dialkylphosphoramidates from Dialkylphosphites." Australian Journal of Chemistry 60, no. 11 (2007): 879. http://dx.doi.org/10.1071/ch07081.

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The present paper describes the one-pot synthesis of dialkyl N,N-dialkylphosphoramidates (DADAP) from dialkylphosphites and dialkylamines using N,N′-dichlorobis(2,4,6-trichlorophenyl)urea (CC-2) as chlorinating reagent. DADAP belong to the schedule 2.B.6 category of the Chemical Weapons Convention (CWC), as they are the important markers of the chemical warfare agent tabun and its analogues. The study was undertaken to develop the spectral database of DADAP for verification of CWC. The reported synthetic strategy can be adopted to rapidly synthesize several analogues of DADAP during official p
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49

Iwagaki, Hiromi, Akio Hizuta, Kenta Kobashi, Hiroshi Isozaki, Norihisa Takakura, and Noriaki Tanaka. "Clinical Value of Neopterin In Infectious Complications." Pteridines 10, no. 1 (1999): 20–23. http://dx.doi.org/10.1515/pteridines.1999.10.1.20.

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Neopterin, a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocyte/macrophages upon stimulation, mainly by gamma-interferon by activated T cells. C-reactive protein (CRP) is one of the major acute phase reactants and its release is thought to be mediated by interleukin-6. Soluble IL-2 receptor (sIL-2R) is released by activated T cells. Plasma concentrations of neopterin, CRP and sIL-2R were synchronously analyzed in 25 determinations of 5 patients with severe infectious complications. A marked increase in neopterin, CRP and sIL-2R levels
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50

Shafea Saad, Farina Hanif, Shabana Usman Simjee, Shaheen Faizi, Lubna Khan, and Ambreen Ashfaque. "Modulation of Apoptotic and Akt/PI3K/mTOR pathways to target Glioblastoma Cells using synthetic compound PGEA-AN." Journal of the Pakistan Medical Association 74, no. 2 (2024): S39—S46. http://dx.doi.org/10.47391/jpma-duhs-s09.

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Objective: To investigate the anticancer potential of a novel synthetic derivative of a naturally occurringditerpenoid against glioblastoma.Method: The in vitro study was conducted at the Ojha Campus of Dow University of Health Sciences, Karachi, fromFebruary to December 2021, and comprised U87 cells. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay was used to determine the growth inhibitory effect of 16(R and S) – phenylamino-cleroda3, 13(14) Zdiene-15, 16 olide and standard drug temozolomide against glioblastoma cells, and half-maximal inhibitoryconcentration was calcul
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