Relevant bibliographies by topics / Target differentiation

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Target differentiation'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Target differentiation"

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Esau, Christine, Xiaolin Kang, Eigen Peralta, et al. "MicroRNA-143 Regulates Adipocyte Differentiation." Journal of Biological Chemistry 279, no. 50 (2004): 52361–65. http://dx.doi.org/10.1074/jbc.c400438200.

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MicroRNAs (miRNAs) are endogenously expressed 20-24 nucleotide RNAs thought to repress protein translation through binding to a target mRNA (1-3). Only a few of the more than 250 predicted human miRNAs have been assigned any biological function. In an effort to uncover miRNAs important during adipocyte differentiation, antisense oligonucleotides (ASOs) targeting 86 human miRNAs were transfected into cultured human pre-adipocytes, and their ability to modulate adipocyte differentiation was evaluated. Expression of 254 miRNAs in differentiating adipocytes was also examined on a miRNA microarray.
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Figueroa, Angélica, Ana Cuadrado, Jinshui Fan, et al. "Role of HuR in Skeletal Myogenesis through Coordinate Regulation of Muscle Differentiation Genes." Molecular and Cellular Biology 23, no. 14 (2003): 4991–5004. http://dx.doi.org/10.1128/mcb.23.14.4991-5004.2003.

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ABSTRACT In this report, we investigate the role of the RNA-binding protein HuR during skeletal myogenesis. At the onset of myogenesis in differentiating C2C12 myocytes and in vivo in regenerating mouse muscle, HuR cytoplasmic abundance increased dramatically, returning to a predominantly nuclear presence upon completion of myogenesis. mRNAs encoding key regulators of myogenesis-specific transcription (myogenin and MyoD) and cell cycle withdrawal (p21), bearing AU-rich regions, were found to be targets of HuR in a differentiation-dependent manner. Accordingly, mRNA half-lives were highest duri
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Huberman, A. D. "Target-Derived Cues Instruct Synaptic Differentiation." Journal of Neuroscience 26, no. 4 (2006): 1063–64. http://dx.doi.org/10.1523/jneurosci.4456-05.2006.

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Nishi, Rae. "Target-mediated control of neural differentiation." Progress in Neurobiology 69, no. 4 (2003): 213–27. http://dx.doi.org/10.1016/s0301-0082(03)00046-7.

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Liu, Zhihui, Xiyuan Zhang, Man Xu, et al. "MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription." PLOS Biology 22, no. 3 (2024): e3002240. http://dx.doi.org/10.1371/journal.pbio.3002240.

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MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis, and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely understood. Our study finds that MYCN binds promoters to up-regulate canonical MYC targets but binds to both enhancers and promoters to repress differentiation genes. MYCN binding also increases H3K4me3 and H3K27ac on canonical MYC target promoters and decreases H3K27ac on neuronal differentiation gene enhancers and promoters. WDR5 facilitates MYCN promo
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Cardus, Daniela F., Mitchell T. Smith, Alexandra Vernaza, et al. "Systematic Analysis of miR-506-3p Target Genes Identified Key Mediators of Its Differentiation-Inducing Function." Genes 15, no. 10 (2024): 1268. http://dx.doi.org/10.3390/genes15101268.

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Background/Objectives: miR-506-3p has been demonstrated to be a strong inducer of neuroblastoma cell differentiation, highlighting the potential of applying miR-506-3p mimics to neuroblastoma differentiation therapy. However, the target genes of miR-506-3p that mediate its differentiation-inducing function have not been fully defined. This study aims to comprehensively investigate the targetome of miR-506-3p regarding its role in regulating neuroblastoma cell differentiation. Methods: We combined gene expression profiling and functional high-content screening (HCS) to identify miR-506-3p targe
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Hao, Wei, Hongzhi Liu, Lugang Zhou, et al. "MiR-145 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells through targeting FoxO1." Experimental Biology and Medicine 243, no. 4 (2017): 386–93. http://dx.doi.org/10.1177/1535370217746611.

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In this study, we aimed to investigate the expression of miR-145 before and after hASCs osteogenic differentiation. We also intended to explore the influence of the target relationship between miR-145 and FoxO1 on osteogenic differentiation. Dual-luciferase reporter gene assay and real-time PCR were used to confirm the target relationship between miR-145 and FoxO1. Furthermore, the modulatory effects of miR-145 and FoxO1 on hASCs osteoinductive differentiation were measured by real-time PCR , Western blot, ALP staining, ARS staining, and cell immunofluorescence assay. After osteogenic differen
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Hahn, Cynthia K., Kenneth N. Ross, Rose M. Kakoza, et al. "Syk Is a New Target for AML Differentiation." Blood 110, no. 11 (2007): 209. http://dx.doi.org/10.1182/blood.v110.11.209.209.

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Abstract One of the challenges of phenotype-based small molecule screening has been the difficulty of protein target identification for newly discovered compounds. For example, we previously performed a gene expression-based small molecule library screen, which identified gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, as an inducer of acute myeloid leukemia (AML) differentiation in cell lines and primary patient cells. Neither EGFR transcript nor protein is expressed in the tested AML cell lines, thus precluding inhibition of this kinase as the mechanism of AML differentiatio
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Callens, Celine, Séverine Coulon, Jerome Naudin, et al. "Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia." Journal of Experimental Medicine 207, no. 4 (2010): 731–50. http://dx.doi.org/10.1084/jem.20091488.

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Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML). However, only the combinations of all-trans retinoic acid or arsenic trioxide with chemotherapy have been successful, and only in treating acute promyelocytic leukemia (also called AML3). We show that iron homeostasis is an effective target in the treatment of AML. Iron chelating therapy induces the differentiation of leukemia blasts and normal bone marrow precursors into monocytes/macrophages in a manner involving modulation of reactive oxygen species expression and the
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Kim, Hak Kyun, Yong Sun Lee, Umasundari Sivaprasad, Ankit Malhotra, and Anindya Dutta. "Muscle-specific microRNA miR-206 promotes muscle differentiation." Journal of Cell Biology 174, no. 5 (2006): 677–87. http://dx.doi.org/10.1083/jcb.200603008.

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Three muscle-specific microRNAs, miR-206, -1, and -133, are induced during differentiation of C2C12 myoblasts in vitro. Transfection of miR-206 promotes differentiation despite the presence of serum, whereas inhibition of the microRNA by antisense oligonucleotide inhibits cell cycle withdrawal and differentiation, which are normally induced by serum deprivation. Among the many mRNAs that are down-regulated by miR-206, the p180 subunit of DNA polymerase α and three other genes are shown to be direct targets. Down-regulation of the polymerase inhibits DNA synthesis, an important component of the
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Dissertations / Theses on the topic "Target differentiation"

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Ferguson, Charmaine. "Development of an in vitro model of neuronal differentiation and nerve-target interaction." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27356.

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My objective was to develop a nerve source for use in a 3-dimensional in vitro model to study neurite extension and target innervation. A hybrid neuroblastoma-DRG cell line (ND-C) with properties of neuronal precursors was examined for its ability to effectively differentiate into neurons, produce extensive neurites, and interact with target cells. Neuronal differentiation of ND-Cs was optimized through a combinatorial approach that involved culturing the cells in the presence of various types of culture media, ECM, and soluble factors in a dose dependent fashion. The proportion of neurons an
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Raif, Anna Women's &amp Children's Health Faculty of Medicine UNSW. "Neuroblastoma tumorigenesis: arrested differentiation as a mechanism of disease, and a treatment target." Publisher:University of New South Wales. Women's & Children's Health, 2009. http://handle.unsw.edu.au/1959.4/43639.

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The molecular mechanisms of neuroblastoma tumorigenesis include arrested neuritic differentiation, making an attractive strategy for treatments which promote differentiation of this childhood disease. The N-Myc oncoprotein has an established role in neuroblastoma tumorigenesis, although the exact mechanism is poorly defined. Treatment side-effects are extensive in treatment of children receiving conventional chemo-radiotherapy for neuroblastoma. Retinoids have a low side-effect profile and are used in children with neuroblastoma at the point of minimal residual disease. Retinoids can simultane
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Alkawafi, Isma A. "Role of mammalian target of rapamycin (mTOR) signalling in BeWo trophoblast differentiation and fusion." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/76206/.

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Foetal growth and development is closely related to the placental transport function, since any defect in this function is associated with pathological foetal growth. Trophoblast differentiation into a multinucleate syncytium is a key biological mechanism. Transcriptional regulation of fusogenic genes to promote fusion and capacity for placental hormonogenesis is achieved by a coordinated action of signals such as cAMP and MAPKs. The mammalian target of rapamycin (mTOR) acts as a placental growth signalling sensor, and this has been implicated in the pathophysiology of diseases such as intraut
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Tang, Chung Yiu Jonathan. "CIS-regulatory integration of intrinsic transcription factors with target-derived signals in neuronal differentiation." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24210.

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We now know that expression of the appropriate terminal differentiation gènes (TDG), such as neuropeptides, neurotransmitters, ion channels, etcetera, in maturing neurons is controlled by cell-specific combinations of transcription factors and by signals secreted from the neurons' target cells. However, it is unclear how thèse two regulatory inputs are integrated inside neurons. In Drosophila, target-derived Bone Morphogenetic Protein (BMP) signals and a well-characterized combinatorial code of transcription factors activate expression of the FMRFa gene in the Tv neurons. Here, I performed a c
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Eusebio, Anthony R. "Characterization of downstream target genes regulated by ABF-1 in different states of B cell development." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/618.

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The ABF-1 gene encodes for a protein that belongs to the basic helix-loop-helix family of transcription factors. ABF-1 mRNA molecules have been detected in the lymphoid tissues, which include the bone marrow, lymph nodes, and appendix, as well as transformed B cells lines infected with Epstein-Barr virus. This study investigates the role of ABF-1 in regulating downstream target genes in the human mature B cell line RAJI, as well as the plasma cell line, ARH-77. Quantitative real-time polymerase chain reaction and DNA microarray technology was used to investigate target genes that are subjected
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Berndt, Anthony Jason Erich. "Cis-regulatory integration of intrinsic and target-dependent regulators is required for terminal differentiation of Drosophila neurons." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55193.

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Yánez-Marcayata, Diana Carolina. "The role of Hedgehog signalling and its target genes in T helper differentiation and Th2 mediated disease." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045576/.

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The process through which CD4 T-cells develop into Th1 and Th2 subsets has been the topic of intensive studies and many proteins are described to be involved. The Hedgehog (Hh) signalling pathway comprises a family of morphogens that are essential during mammalian organogenesis and in the development and homeostasis of T-cells. In addition, Hh signalling is involved in the differentiation of murine Th2 cells and contributes to the development of allergic airway disease. The family of Foxa2 transcription factors are Hedgehog target genes that have also been implicated in the regulation of the i
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Dingels, Nicole Katherine. "Oxidized soybean oil alters the expression of PPAR gamma and target genes in 3T3-L1 cells." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/40.

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Background: The typical western diet contains foods with modest amounts of lipid oxidation products. Previous work by us and others have demonstrated that mildly oxidized lipids promote a gain in fat mass while highly oxidized lipids decrease fat mass in rodents and triglyceride (TAG) accumulation in 3T3-L1 cells. Adipocyte differentiation is regulated by a key nuclear transcription factor known as PPARγ. Objective: To investigate if the alterations in triglyceride accumulation in 3T3-L1 cells pretreated with oxidized soy oil are due to 1) a change in PPARg DNA interactions 2) changes in the
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Hammon, Kathrin [Verfasser], and Wolfgang [Akademischer Betreuer] Herr. "IDH mutations as immune target and their effect on dendritic cell differentiation and metabolism / Kathrin Hammon ; Betreuer: Wolfgang Herr." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/120188408X/34.

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Mändl, Julia [Verfasser], and Martin [Akademischer Betreuer] Müller. "The Growth Differentiation Factor 15 – a Novel Cellular Target Gene for Oncogenic Human Papillomaviruses / Julia Mändl ; Betreuer: Martin Müller." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1236812964/34.

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Books on the topic "Target differentiation"

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Godin, Seth. Meatball sundae: Is your marketing out of sync? Portfolio, 2008.

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Godin, Seth. Meatball Sundae. 4th ed. HighBridge Company, 2007.

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Godin, Seth. Meatball Sundae: Is Your Marketing out of Sync? Portfolio Hardcover, 2007.

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Campione, Marina, Amelia Aranega, and Diego Franco. Cardiac looping and laterality. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0014.

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Dextral looping is a complex process which progresses concomitantly with cardiac chamber differentiation and ultimately leads to the final alignment of the cardiac regions. Generation of cardiac asymmetry is crucial to ensure the proper form and consequent function of the heart and thus is a highly regulated process. Molecular signals originate long before morphological asymmetry and therefore can direct it; a complex regulatory network has been characterized which invariably converges on the Tgf-β‎ signalling molecule Nodal and its downstream target, the homeobox transcription factor Pitx2. W
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Burhenn, Peggy S. Delirium. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190204709.003.0007.

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This chapter provides an overview of delirium, differentiating among hyperactive, hypoactive, and mixed subtypes. Delirium is a common, serious medical problem that is underrecognized by healthcare providers. Evidence suggests that frequent assessment of patients can result in increased recognition of delirium, which will allow for earlier intervention. Limited data are available on effective interventions for delirium once it begins; however, proactive prevention strategies have been successful. Various screening tools are recommended to identify patients with delirium. The multiple predispos
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Patterson, Caroline, and Derek Bell. Causes and diagnosis of chest pain. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0144.

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Differentiating life-threatening from benign causes of chest pain in the critical care setting is a challenge when the symptoms and signs overlap, and patients are unable to communicate fully. A high index of suspicion is required for occult disease. Once the clinician has ensured the patient is haemodynamically stable, it is imperative to rule out myocardial infarction in the first instance. Where possible, a thorough history and a full examination should be undertaken. Electrocardiogram, chest X-ray, and routine observations are often diagnostic. Targeted investigation such as computed tomog
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Ponti, Cesare, Paola Schwizer, Floricel Rugiero, et al. Governance e strategia per la gestione dei rischi nelle imprese non finanziarie. AIFIRM, 2020. http://dx.doi.org/10.47473/2016ppa00024.

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The “Corporate Risk Governance & Control” Commission, composed of risk managers, working for the top leading companies and financial institutions, many of which are publicly listed, as well as academics and board members, worked together to produce a position paper that aspires to provide principles and best practices regarding strategic risk management and risk governance. In particular, the document provides a framework, applicable to non financial companies based on their specific profiles, that integrates the general requirements established by the standard setters (i.e. the Code of Co
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Book chapters on the topic "Target differentiation"

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Loo, C. K., W. S. Lim, and M. V. C. Rao. "Classifiers for Sonar Target Differentiation." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30133-2_39.

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Bakó, László, Sirpa Nuotio, Dénes Dudits, Jeff Schell, and Csaba Koncz. "RNAPII: A Specific Target for the Cell Cycle Kinase Complex." In Results and Problems in Cell Differentiation. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-540-48037-2_2.

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Oufroukh, Naima Ait, and Etienne Colle. "Neural Networks for Improved Target Differentiation with Sonar." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-27868-9_39.

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Aplin, J. D. "The Glycoprotein MUC1 and Extracellular Matrix Molecules as Markers of Endometrial Differentiation." In The Endometrium as a Target for Contraception. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-10323-4_8.

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Breindl, Michael, Ulrich Scherdin, and Kate Rhodes. "Cellular Target Sequences for Retrovirus Integration." In Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74197-5_8.

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Buzanska, Leonora, Marzena Zychowicz, and Agnieszka Kinsner-Ovaskainen. "Bioengineering of the Human Neural Stem Cell Niche: A Regulatory Environment for Cell Fate and Potential Target for Neurotoxicity." In Results and Problems in Cell Differentiation. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-93485-3_9.

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Barthold, Mare, H. Mayer, and Volker Jäger. "Cultivation of Primary Osteogenic Cells in Serum-Reduced or Serum-Free Culture Media: Attachment, Proliferation and Differentiation." In Animal Cell Technology: From Target to Market. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0369-8_139.

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MacDonald, Susan M. "History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy." In Results and Problems in Cell Differentiation. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67591-6_16.

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Hau, Kwan-Leong, Amelia Lane, Rosellina Guarascio, and Michael E. Cheetham. "Eye on a Dish Models to Evaluate Splicing Modulation." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_16.

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AbstractInherited retinal dystrophies, such as Leber congenital amaurosis, Stargardt disease, and retinitis pigmentosa, are characterized by photoreceptor dysfunction and death and currently have few treatment options. Recent technological advances in induced pluripotent stem cell (iPSC) technology and differentiation methods mean that human photoreceptors can now be studied in vitro. For example, retinal organoids provide a platform to study the development of the human retina and mechanisms of diseases in the dish, as well as being a potential source for cell transplantation. Here, we descri
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Ionin, Tania, and Chung-Yu Chen. "Chapter 12. There isn’t a problem with indefinites in existential constructions in L2-English." In Language Acquisition and Language Disorders. John Benjamins Publishing Company, 2024. http://dx.doi.org/10.1075/lald.70.12ion.

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This is an exploratory study of how both native English speakers and L1-Mandarin L2-English learners judge different types of indefinites in both existential there-constructions and copular constructions with an indefinite subject. Unlike English, Mandarin lacks an a/one distinction, has two different types of existential constructions, and lacks numeral partitives. It is argued that target differentiation among indefinite types and syntactic constructions presents a Poverty of the Stimulus problem. Learners are found to overcome this problem: while there is limited evidence of L1-transfer fro
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Conference papers on the topic "Target differentiation"

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Liu, Jing, Yue Ye, Yang Li, Xinxin Cheng, and Yi Liu. "HRRP Radar Target Recognition Based on Amplitude Spectrum Fractional Differentiation." In 2024 20th International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery (ICNC-FSKD). IEEE, 2024. http://dx.doi.org/10.1109/icnc-fskd64080.2024.10702332.

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Shi, Yichun. "U-DualMAR: Dual Differentiation Network for Maritime Small Target Segmentation." In 2025 7th International Conference on Information Science, Electrical and Automation Engineering (ISEAE). IEEE, 2025. https://doi.org/10.1109/iseae64934.2025.11041755.

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Santana, Vinicius, Andr�s Riedemann, Pierre J. Walker, and Idelfonso Nogueira. "Langmuir.jl: An Efficient and composable Julia Package for Adsorption Thermodynamics." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.144752.

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Recent advancements in material design have made adsorption a more energy-efficient alternative to traditional thermally driven separation processes. Accurate modelling of adsorption thermodynamics is crucial for designing and operating equilibrium-limited adsorption systems. High-quality open-source packages like PyIAST, PyGAPsare available for processing adsorption data in Python. They provide a robust set of features for processing and analysing isotherms. However, they have no support for automatic differentiation and are not targeted for performance. Langmuir.jl addresses these limitation
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LIM, W. S., M. V. C. RAO, and C. K. LOO. "NEURAL NETWORK BASED SONAR TARGET DIFFERENTIATION." In Proceedings of the 6th International FLINS Conference. WORLD SCIENTIFIC, 2004. http://dx.doi.org/10.1142/9789812702661_0078.

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Aytac, Tayfun, and Billur Barshan. "Target differentiation and localization using infrared sensors." In 19th Congress of the International Commission for Optics: Optics for the Quality of Life, edited by Giancarlo C. Righini and Anna Consortini. SPIE, 2003. http://dx.doi.org/10.1117/12.530093.

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Kadlimatti, Ravi, and Adly T. Fam. "Isolating target return from reflections via Doppler differentiation." In 2016 IEEE Radar Conference (RadarConf16). IEEE, 2016. http://dx.doi.org/10.1109/radar.2016.7485139.

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Aytac, Tayfun, Cagri Yuzbasioglu, and Billur Barshan. "Statistical Pattern Recognition Techniques for Target Differentiation using Infrared Sensor." In 2006 IEEE International Conference on Multisensor Fusion and Integration for Intelligent Systems. IEEE, 2006. http://dx.doi.org/10.1109/mfi.2006.265631.

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Khodabandeh, M., M. Analoui, and A. Mohammad-Shahri. "Target differentiation using sonar data for robot applications; neural network approach." In 2007 International Conference on Control, Automation and Systems. IEEE, 2007. http://dx.doi.org/10.1109/iccas.2007.4406669.

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Sambbantham, Jagadesh, Gomathy Balasubramanian, Rajarathnam, and Mohit Tiwari. "A Linear Differentiation Scheme for Camouflaged Target Detection using Convolution Neural Networks." In RAiSE-2023. MDPI, 2023. http://dx.doi.org/10.3390/engproc2023059045.

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MIHAYLOVA, Lyudmila, Emil PAPAZOV, and Rashid Sultan Rashid AlKaitoob ALNUAIM. "DUBAI’S ECONOMIC ENVIRONMENT AND BUSINESS DIFFERENTIATION." In International Management Conference. Editura ASE, 2023. http://dx.doi.org/10.24818/imc/2022/03.06.

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This paper discusses issues of the economic environment in connection with organizational highquality (differentiation) strategy and business orientation. The specificity of the cutting-edge hightech business environment based on knowledge enables enterprises to orient with greater confidence towards a strategy of high quality of the offered products and services. The purpose of the report is to present and analyse elements of the business environment in Dubai, serving as a prerequisite for the implementation of the strategy of high quality. An example of the relationship between the high-tech
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Reports on the topic "Target differentiation"

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Pasternack, Gary R. Target Identification for Differentiation Therapy of Prostate Cancer. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada508627.

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Li, Hua. Identification of Pro-Differentiation p53 Target Genes and Evaluation of Expression in Normal and Malignant Mammary Gland. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada471561.

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Chansiripornchai, Piyarat, and Thanaphum Osathanon. In vitro differentiation of mesenchymal stem cells from dental and oral tissues into Islet-like cell cluster. Chulalongkorn University, 2013. https://doi.org/10.58837/chula.res.2013.93.

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Diabetes mellitus is a complicated metabolic disorder resulting in hyperglycemia and long-term complications e.g. diabetic encephalopathy and neuropathy. Treatments of diabetes and its complications have faced many obstacles. Trend of stem cells (SCs)-based therapy has been proposed as a novel approach. Though, the study using dental SCs in this regard is yet lacking. In this study, human dental pulp SCs (hDPSCs) and human periodontal ligament SCs (hPDLSCs) were employed. The results illustrated the capability of differentiation toward islet-like cells (ILCs) cluster / insulin-producing cells
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Becker, Sarah, Heather Sussman, S. Blundell, Vern Vanderbilt, and Igor Semyonov. Analysis of spectropolarimetric responses in the visible and infrared for differentiation between similar materials. Engineer Research and Development Center (U.S.), 2022. http://dx.doi.org/10.21079/11681/45422.

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Spectropolarimetric research has focused on target detections of materials that have a high degree of contrast from background materials, such as identification of a manmade object embedded in a vegetative background. This study presents an approach using spectropolarimetric imagery in visible, shortwave infrared, and longwave infrared bands to differentiate between similar natural and manmade materials. The method employs Michelson contrast and Kruskal-Wallis one-way analysis of variance (ANOVA) H-test to determine if a distinction can be found in pairwise comparisons of similar and different
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Gan, Charles, Melissa Pitton, Jolinda de Korne, et al. Wastewater-based poliovirus surveillance using digital PCR. Swiss Federal Institute of Aquatic Science and Technology, Eawag, 2025. https://doi.org/10.55408/eawag:34819.

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Poliovirus is the causative agent of poliomyelitis, a potentially debilitating disease that is a target for global eradication. Vaccination against poliomyelitis is an important tool in the eradication effort, but one of the available vaccines, the oral poliovirus vaccine, contains live, attenuated strains that can revert to virulent forms. Community transmission of so-called vaccine-derived polioviruses (VDPVs) can contribute to outbreaks, including in areas with no recently reported poliomyelitis cases. Wastewater-based surveillance (WBS) is a widely applied method to monitor communities for
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Dickman, Martin B., and Oded Yarden. Regulation of Early Events in Hyphal Elongation, Branching and Differentiation of Filamentous Fungi. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580674.bard.

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In filamentous fungi, hyphal elongation, branching and morphogenesis are in many cases the key to successful saprophytic and pathogenic fungal proliferation. The understanding of the fungal morphogenetic response to environmental cues is in its infancy. Studies concerning the regulation of fungal growth and development (some of which have been obtained by the participating collaborators in this project) point to the fact that ser/thr protein kinases and phosphatases are (i) involved in the regulation of such processes and (ii) share common structural and functional features between saprophytes
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Sun, Lina, Yanan Han, Hua Wang, et al. MicroRNAs as Potential Biomarkers for the Diagnosis of Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.2.0027.

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Review question / Objective: The purpose of this systematic review was to systematically review the clinical studies regarding miRNAs as diagnostic biomarkers for inflammatory bowel disease and assess the overall diagnostic accuracy of miRNAs. Condition being studied: The symptoms of inflammatory bowel disease (IBD) are highly variable. The diagnosis of IBD must be made through medical history, physical, laboratory, radiologic, endoscopic, and histological examinations. However, these diagnostic techniques are not specific and sometimes even equivocal. Therefore, reliable biomarkers are urgent
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Andrabi, Tahir, Natalie Bau, Jishnu Das, Naureen Karachiwalla, and Asim I. Khwaja. Crowding in Private Quality: The Equilibrium Effects of Public Spending in Education. Research on Improving Systems of Education (RISE), 2023. http://dx.doi.org/10.35489/bsg-rise-wp_2023/124.

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We estimate the equilibrium effects of a public school grant program administered through school councils in Pakistani villages with multiple public and private schools and clearly defined catchment boundaries. The program was randomized at the village-level, allowing us to estimate its causal impact on the market. Four years after the start of the program, test scores were 0.2 sd higher in public schools. We find evidence of an education multiplier: test scores in private schools were also 0.2 sd higher in treated markets. Consistent with standard models of product differentiation, the educat
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Casey, Therese, Sameer J. Mabjeesh, Avi Shamay, and Karen Plaut. Photoperiod effects on milk production in goats: Are they mediated by the molecular clock in the mammary gland? United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598164.bard.

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US scientists, Dr. Theresa Casey and Dr. Karen Plaut, collaborated with Israeli scientists, Dr. SameerMabjeesh and Dr. AviShamay to conduct studies proposed in the BARD Project No. US-4715-14 Photoperiod effects on milk production in goats: Are they mediated by the molecular clock in the mammary gland over the last 3 years. CLOCK and BMAL1 are core components of the circadian clock and as heterodimers function as a transcription factor to drive circadian-rhythms of gene expression. Studies of CLOCK-mutant mice found impaired mammary development in late pregnancy was related to poor lactation p
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Levisohn, Sharon, Maricarmen Garcia, David Yogev, and Stanley Kleven. Targeted Molecular Typing of Pathogenic Avian Mycoplasmas. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695853.bard.

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Intraspecies identification (DNA "fingerprinting") of pathogenic avian mycoplasmas is a powerful tool for epidemiological studies and monitoring strain identity. However the only widely method available for Mycoplasma gallisepticum (MG) and M. synoviae (MS)wasrandom amplified polymorphic DNA (RAPD). This project aimed to develop alternative and supplementary typing methods that will overcome the major constraints of RAPD, such as the need for isolation of the organism in pure culture and the lack of reproducibility intrinsic in the method. Our strategy focussed on recognition of molecular mark
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