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Dissertations / Theses on the topic 'TCR'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Groves, Tim C. "Pre-TCR and TCR-Ãß signaling during T cell development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27657.pdf.

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2

Currie, James. "Stochastic modelling of TCR binding." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590430.

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A fundamental process in the immune response to infection is the activation of T cells following contact with antigen presenting cells. This activation occurs after T cell receptors on the surface of T cells bind to immunogenic peptides expressed on the surface of antigen presenting cells. The binding of T cell receptors to ligands not only leads to the activation of T cells, it is also key to T cell selection in the thymus and the maintenance of a diverse T cell receptor repertoire. T cell receptor bindings are converted into a signal which activates a T cell but there is no universal theory
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3

Lacroix, France. "T cell receptor (TCR) for antigen: A comparative study between the TCR alpha/beta and TCR gamma/delta subsets in noninfected and HIV infected individuals." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6937.

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HIV infection is associated with characteristic quantitative changes in T-lymphocyte subsets: progressive depletion of the CD4$\sp{+}$ T-lymphocytes and an increased number of the CD8$\sp{+}$ T-lymphocyte. In this study, I report the results of a flow cytometric analysis of the expression of CD3, CD4, CD8, TCR$\alpha$/$\beta$, and TCR$\gamma$/$\delta$ antigens. I observed that CD8$\sp{+}$TCR$\alpha$/$\beta\sp{+}$ cells increased early in HIV disease (p 0.01) whereas the frequency of CD4$\sp{+}$TCR$\alpha$/$\beta\sp{+}$ cells was relatively unchanged. The frequency of TCR$\gamma$/$\delta\sp{+}
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4

Mariathasan, Sanjeev. "TCR-mediated signaling in thymocyte selection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63683.pdf.

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5

Rivera, Reyes Brenda Mariola. "Regulation of the TCR signaling pathway." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1132588714.

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6

Barry, A. C. "Regulation of TCR signalling by SOCS." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479241.

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7

Mallaun, Michel. "Proximal TCR signaling in self tolerance /." [S.l.] : [s.n.], 2008. http://edoc.unibas.ch/diss/DissB_8729.

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8

Huang, Elizabeth Chi-Fang. "Organisation of, and ligand-independent signalling by, the TCR, with a special emphasis on the pre-TCR." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:0c01e3d4-2002-487c-a0b6-09ed20cb223b.

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Understanding how immune signalling is initiated and regulated spatiotemporally is likely to be helped by investigations of receptor stoichiometry. The pre-TCR expressed by thymocytes shares similarities in structure and signalling components with the mature TCR but, in contrast to the TCR, it has no known ligands. This thesis has therefore analysed the stoichiometry of the pre-TCR using mutagenesis- and imaging-based approaches, and explored how ligand-independent signalling might be initiated by both the TCR and pre-TCR. The mutational analysis, which required considerable optimisation becau
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9

Bunse, Mario. "RNAi-mediated knockdown of the endogenous TCR improves safety of immunotherapy with TCR gene-modified T cells." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17155.

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Durch den Transfer der Gene des heterodimeren T-Zellrezeptors (TZR) mithilfe viraler Vektoren können T-Zellen programmiert werden, ein ausgewähltes Antigen spezifisch zu erkennen. In klinischen Studien wurden solche T-Zellen bereits mit Erfolg zur Immuntherapie von Krebs und viralen Infektionen eingesetzt. Genmodifizierte T-Zellen unterscheiden sich jedoch von normalen T-Zellen, weil sie neben den beiden zelleigenen auch die zwei übertragenen TZR-Gene exprimieren. Diese Situation erlaubt die Bildung vier verschiedener TZR-Heterodimere: der zelleigene TZR, der übertragene TZR und zwei gemischte
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10

Sommermeyer, Daniel. "Generation of dual T cell receptor (TCR) T cells by TCR gene transfer for adoptive T cell therapy." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16051.

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Die Herstellung von T-Zellen mit definierten Spezifitäten durch den Transfer von T-Zellrezeptor (TCR) Genen ist eine effiziente Methode, um Zellen für eine Immuntherapie bereitzustellen. Eine besondere Herausforderung ist dabei, ein ausreichend hohes Expressionsniveau des therapeutischen TCR zu erreichen. Da T-Zellen mit einem zusätzlichen TCR ausgestattet werden, entsteht eine Konkurrenzsituation zwischen dem therapeutischen und dem endogenen TCR. Bevor diese Arbeit begonnen wurde war nicht bekannt, welche TCR nach einem Gen-Transfer exprimiert werden. Daher haben wir Modelle etabliert, in de
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11

Smelty, Philippe. "Caractérisation de la chaîne pré-TCR alpha, constituant du pré-TCR, chez les vertébrés non-mammaliens : étude comparative." Paris 6, 2010. http://www.theses.fr/2010PA066740.

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Chez les mammifères, le développement intrathymique des lymphocytes T est conditionné par l’expression d’une molécule clé appelée chaîne pré-TCR alpha (pTa). Celle-ci forme un hétérodimère avec la chaîne TCR pour constituer à la surface des thymocytes le pré-TCR, indispensable à la poursuite de la maturation des lymphocytes T. La fonction du pré-TCR serait ligand indépendant et se déroulerait par homo-oligomérisation du pré-TCR médiée par la pTa. La pTa n’avait été caractérisée que chez 3 espèces mammifères. Mon travail a permis d’identifier la pTa chez toutes les classes de mammifères, mais é
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12

Borger, J. G. "Visualising early signaling events during TCR activation." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/758822/.

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T cell activation, differentiation and expansion are induced by signals generated upon engagement of TCR by agonist peptide:MHC. At the site of T cell interaction with an antigen presenting cell, TCR, accessory proteins such as CD28 and LFA-1, and the Src family kinases (SFK) Lck and Fyn, accumulate and form the immunological synapse. Lck is the key signaling molecule, initiating TCR signals by phosphorylating the ITAM in the CD3/ subunits resulting in the recruitment and activation of Zap-70 and further propagation of the signaling cascade. Fyn is a positive mediator of T cell signaling, shar
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13

Perro, M. "Lentiviral TCR gene transfer for tumour immunotherapy." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/134272/.

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The ability to manipulate the immune system to induce protection against tumour, is one of the most fascinating challenges in immunology. In this regard, TCR gene transfer is an attractive and powerful strategy to generate high numbers of tumour antigen-specific T cells for adoptive transfer treatment. This thesis describes the optimization of lentiviral vectors for TCR gene transfer in the absence of polyclonal activation of the transduced T cells, which may improve subsequent adoptive T cell therapy. The murinised and codon optimised chains of an HLA-A*0201-restricted TCR specific for Wilms`
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14

Nicholson, E. K. "Enhancing the efficacy of TCR gene therapy." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1418205/.

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TCR gene therapy allows redirection of the antigen specificity of T cells by the introduction of novel TCR α and β chains by retroviral transduction. These TCR gene modified T cells can be adoptively transferred to target defined tumour antigens. The majority of TCR gene therapy studies has focused on the adoptive transfer of CD8+ T cells but there is increasing recognition of a central role for CD4+ T cells in effective immunotherapy protocols. The use of CD4+ T cells has been limited by the lack of well defined class II restricted TCR and also because the majority of tumours don’t express cl
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15

Bruger, Annika Målin. "TCR signalling in response to affinity stimulation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:5f9c1001-6c43-472f-a495-c9573b54a84a.

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T cells are an essential part of the adaptive immune system and protect the body from intracellular infections. The specificity with which αßTCR-bearing T cells recognize cognate antigen presented on MHC molecules is paramount to maintaining the balance between mounting effector functions against pathogens and establishing peripheral tolerance to self. The mechanism by which T cells translate qualitative differences in TCR:pMHC binding to sensitive proximal signalling events which ultimately result in specific Tcell effector responses to infected cells but not to self is mostly unknown. To add
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16

Trinquand, Amélie. "Leucémies Aigues Lymphoblastiques T et signalisation TCR." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05S008.

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Les Leucémies Aigues Lymphoblastiques T (LAL-T) sont des hémopathies malignes causées par la prolifération de cellules immatures T bloquées à un stade donné de leur différenciation. Leur oncogenèse est multigénique. Une anomalie de type A (à l’origine du blocage de différenciation) ainsi que des anomalies de type B (gains de fonctions de type prolifération, métabolisme, résistance à l’apoptose…) sont souvent retrouvées chez le même patient. Ces leucémies reproduisent individuellement les différentes étapes de la maturation thymique humaine. En fonction de l’immunogénétique (phénotype et réarra
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17

Mancini, Stéphane. "Différenciation des lymphocytes T et recombinaison des gènes du TCR : quel rôle pour le pré-TCR dans la régulation du réarrangement des gènes codant pour la chaîne [alpha] du TCR ?" Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10116.

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Les genes codant pour les chaines alpha et beta du recepteur a l'antigene des cellules t (tcr) sont rearranges sequentiellement durant la differenciation intrathymique des lymphocytes t, caracterisee par l'expression de plusieurs molecules membranaires, dont cd4 et cd8. Le rearrangement des genes tcrb, codant pour la chaine beta, intervient durant le stade cd4 8 (dn), et permet l'expression d'un pre-tcr comprenant la chaine beta, ptalpha et le complexe cd3, responsable de la transduction des signaux d'activation. L'assemblage du pre-tcr induit la maturation des thymocytes jusqu'au stade cd4 +8
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18

Trenh, Peter. "An Examination of MHC, Peptide, and TCR Interactions." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/989.

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T cell receptors (TCR) bind to peptides from various sources on MHC (Major Histocompatibility Complex) molecules. A long-standing goal in the field is to understand the mechanisms of MHC-peptide exchange and MHC-TCR interactions. Here, I present work from three uniquely different systems that address the following: HLA-DR1 conformational stability, self-tolerant mechanisms of TCRs isolated from self-reactive TCR transgenic mice, and TCR cross-reactivity mechanisms between LCMV and VV. First, I present a crystal structure of HLA-DR1 in complex with A1L9 peptide, a peptide with two amino acid su
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19

Reuß, Simone. "Safety analysis of TCR gene-modified T cells." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16503.

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T-Zellrezeptor (TZR)-Gentherapie zeigte erste Erfolge in klinischen Studien, jedoch wurden gleichzeitig Risikofaktoren deutlich. Ein Risikofaktor ist das falsche Paaren der transferierten TZR-Ketten mit den endogenen, was zu TZR-Molekülen von unbekannter Spezifität führt und die Oberflächenexpression und somit auch die Funktionalität des transgenen TZR reduziert. Dieser Aspekt wurde in generierten T-Zellklonen mit einer konstitutiven/endogenen TZR-Expression sowie einer zweiten induzierbaren/transgenen TZR-Expression untersucht. Es konnte gezeigt werden, dass nach Induktion der transgenen TZR-
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20

Stewart-Jones, Guillaume B. E. "Structural and functional analyses of human pMHC/TCR complexes." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413213.

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21

Moysi, Eirini. "T-cell receptor (TCR) usage in HIV-2 infection." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ea3a066f-0043-4c71-88ec-2369de642460.

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Long-term non-progressors (LTPNs) in HIV infection target the structural protein Gag more frequently than individuals who progress to disease. However, the targeting of Gag per se does not always distinguish these two groups. Various factors have been put forth as likely explanations for this discrepancy including differences in the breadth and magnitude of observed responses, the HLA type of the host, the nature of the individual epitopes targeted and the ability of the virus to mutate these antigenic regions. The purpose of this thesis was to examine, using PBMCs isolated from HIV-2 infected
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22

Gallagher, Maighréad. "Régulation de l'expression des gènes codant les chaînes TCR[alpha] et TCR[delta] au cours de la différenciation des lymphocytes T chez la souris." Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10150.

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Le recepteur a l'antigene des lymphocytes t (tcr) se compose de deux modules : le module de transduction du signal, ou complexe cd3 ; et le module de reconnaissance du peptide antigenique, compose de deux chaines clonotypiques, tcralpha et tcrbeta ou tcrgamma et tcrdelta. Celles-ci sont codees par des genes ayant subi une recombinaison somatique de segments variables (v), de diversite (d) pour tcrbeta et tcrdelta uniquement et de jonction (j). Chez la souris, les genes codant les chaines tcralpha et tcrdelta partagent un meme locus, le locus tcrad. L'organisation de ce locus permet l'utilisati
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23

McMahon, Roisin M. "Structures of autoimmune peptide-MHC and TCR peptide-MHC complexes." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526503.

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24

Hotblack, A. C. "Characterising the role of dendritic cells in TCR gene therapy." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1537265/.

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Adoptive transfer of T cell receptor (TCR) gene-modified T cells is a promising field of tumour immunology. However whilst these cells can potently control tumour growth, this occurs in only a subset of patients. In order to devise new strategies to improve the anti-tumour response we need a clear understanding of the mechanisms by which transferred T cells are activated to kill tumours. Whilst dendritic cells (DC) are required to activate and control T cell function in adaptive immune responses it is not known whether control of tumours by adoptively transferred T cells depends on similar int
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25

Guillet, Marina. "Analyse de la régulation du TCR dans différentes situations immunologiques." Nantes, 2002. http://www.theses.fr/2002NANT12VS.

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Grâce à l'utilisation d'une nouvelle méthode d'analyse de la régulation de la chaine β du TCR, nommée TcLandscape, nous avons observé que les cellules T nai͏̈ves stimulées in vitro dans des conditions de reconnaissance " directe " stricte présentaient un profil TCR particulier. En effet, la reconnaissance directe du CMH allogénique par des cellules T nai͏̈ves est associée à une forte accumulation des transcrits Vβ, sans altération de la distribution de taille du CDR3. . . . . Ces profils mettant en évidence des cellules T présentant une distribution altérée de la taille du CDR3 permettent d'id
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26

Frazer, Gordon Lee. "How TCR signal strength controls CTL polarisation for target killing." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277687.

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Cytotoxic T lymphocytes (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the clonally expressed T cell receptor (TCR). TCRs recognise a specific peptide chain loaded into a major-histocompatability complex, triggering signalling, inducing the CTL to attach and kill target cells. Key stages in this attack are the initial conjugation followed by polarisation and docking of the centrosome to the junction of the two cells, the immune synapse (IS). This fo
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27

Bartelt, Rebekah Ruth. "Characterization of GRB2 and SOS1 binding downstream of TCR activation." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3257.

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Despite their essential role in protection, T cells can be dangerous if unregulated. Dysfunctional T cell activity has been implicated in numerous diseases, including the failure of organ transplants, allergic reactions, multiple sclerosis, and coronary artery disease. Signal transduction pathways activated by the T cell receptor (TCR) are good targets for the development of therapies. However, we must first better understand the mechanisms of intracellular signaling that occur when a T cell is activated. This thesis focuses on the scaffold protein LAT and its role in T cell activation. The lo
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28

Potthast, Kerstin. "Interaktion des humanen CD8 mit MHC Klasse I und CD3-TCR." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967744253.

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29

Mutluer, Bilge Halas. "Design, Implementation And Engineering Aspects Of Tcr For Industrial Svc Systems." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609424/index.pdf.

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Design and implementation of TCR (Thyristor Controlled Reactor) for industrial SVC (Static VAr Compensator) systems require special design. Both power stage and control system design and implementation are thoroughly investigated in this thesis. Engineering aspects of TCR design are emphasized and supported with case studies. As the first case study<br>a novel, unified and relocatable SVC for open cast lignite mining in Turkey is designed, implemented and commissioned. The second case study is the first 12 pulse TCR design and implementation for ladle furnace compensation in the world. The SVC
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30

Oble, Darryl. "A TCR transgenic model of infection-induced autoimmune psoriasiform skin disease." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31199.

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Psoriasiform skin diseases are a poorly understood group of disorders. Recent data has implicated the immune system with a central role in disease pathogenesis. In this thesis, various T cell populations were studied in a TCR transgenic model of psoriasiform disease, whose abnormal interactions culminate in distinctive psoriasiform pathology. The model is based upon the expression of the transgenic 2C TCR on the H-2[sup d] -expressing DBA/2 inbred strain (referred to as D2C mice). The 2C TCR recognizes a peptide (p2Ca) derived from the ubiquitous mitochondrial protein 2-oxoglutarate dehydrogen
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31

Gorman, Claire. "Genetic, phenotypic and functional analysis of the TCR zeta (s) chain." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503779.

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32

何沛德 and Pui-tak Ho. "Control and operation of high-performance thyristor-controlled-reactor(TCR) compensators." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B31231160.

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33

Wikstrom, Matthew E. "The regulation of peripheral T cell responses in TCR transgenic mice." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27641.

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Transgenic mice expressing a T cell receptor specific for cytochrome C in association with I-Ek were employed to study the mechanisms regulating the decision between tolerance and immunity. Tolerance and immunity to the same peptide antigen were . induced by using different routes of administration. Thus tolerance was induced by the intravenous route and immunity by the subcutaneous route. The results presented in this thesis provide a detailed map of the cellular events that occur during these two distinct responses. Intravenous immunisation induced activation of CD4+ cells expressin
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34

Bunse, Mario [Verfasser], Wolfgang [Akademischer Betreuer] Uckert, Thomas [Akademischer Betreuer] Blankenstein, and Christian [Akademischer Betreuer] Schmitz-Linneweber. "RNAi-mediated knockdown of the endogenous TCR improves safety of immunotherapy with TCR gene-modified T cells / Mario Bunse. Gutachter: Wolfgang Uckert ; Thomas Blankenstein ; Christian Schmitz-Linneweber." Berlin : Lebenswissenschaftliche Fakultät, 2015. http://d-nb.info/106856895X/34.

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35

Hazgui, Hana. "Modélisation de la dynamique des réseaux biologiques : applications en génétique et immunologie." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAS040/document.

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Dans cette thèse, nous nous intéressons à la modélisation statistique de données biologiques, et plus particulièrement à l'étude de l'information génétique et protéique.Dans un premier volet, nous avons amélioré un modèle statistique des données immunologiques existant chez la souris, que nous avons transposé à l'homme, afin d'étudier les différentes recombinaisons qui apparaissent au sein du thymus, à la fin de la vie embryonnaire, entre les segments des gènes de la portion V(D)J du chromosome 14 humain, appelées recombinaisons V(D)J.Dans un deuxième volet, nous avons étudié l'information gén
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Gangadharan, Denise Michelle. "Thymic development of CS8[alpha][alpha]⁺ TCR[alpha][beta]⁺ agonist selected IEL." Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3189998.

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Thesis (Ph. D.)--University of California, San Diego, 2005.<br>Title from first page of PDF file (viewed Marc 6, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 100-116).
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Cheng, Gordon W. "Functions of CD45 in TCR signaling in CD4§+CD8§+ double-positive thymocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29256.pdf.

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38

Paletta, Daniel Sylvester [Verfasser], and Thomas [Gutachter] Herrmann. "Die Variabilität des Ratten iNKT TCR / Daniel Sylvester Paletta. Gutachter: Thomas Herrmann." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1111783810/34.

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39

Bronnimann, Heather. "Functional Analysis of Interactions within the TCR-CD3-pMHC-CD4 Macro-complex." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/612427.

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CD4⁺ T cells are a critical component of the adaptive immune compartment. Each T cell expresses a clonotypic T cell receptor (TCR) that must discriminate between self and foreign peptides presented in major histocompatibility molecules (pMHC) on the surface of antigen presenting cells to direct T cell fate decisions. Information regarding TCR-pMHC interactions must then be transmitted to the TCR-associated CD3 signaling modules, which contain ITAMs that serve as signaling substrates for Src kinases. The Src kinase, Lck, is recruited to the pMHC-bound TCR-CD3 complex via association with the CD
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40

Villarese, Patrick. "Apport de l'analyse des réarrangements du TCR dans l'oncogenèse et l'ontogénie T." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05S007.

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Les cellules T maturent dans le thymus lors d’un processus très régulé par l’intermédiaire de facteurs intrinsèques, comme des facteurs de transcription, et des facteurs extrinsèques (par exemple des cytokines des cellules stromales). L’acquisition du potentiel T au cours de la thymopoïèse, à partir d’un précurseur médullaire, se réalise grâce à des étapes successives définies par l’expression de molécules de surface et par les différents réarrangements des gènes du TCR qui sont ordonnés : le TCRd étant le premier à se produire, suivi par le TCRg et TCRb, pour finir par le TCRa. Les réarrangem
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Okabe, Namiko. "Suppressor of TCR signaling-2 (STS-2) suppresses arthritis development in mice." Kyoto University, 2018. http://hdl.handle.net/2433/232089.

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42

Majri, Sonia. "Regulation of CD4⁺ memory T cell homeostasis by STAT5 during TCR restimulation." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC139.

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Les facteurs de transcriptions Signal Transducer and Activator Transcription (STAT) sont essentiels pour la régulation de gènes impliqués dans plusieurs fonctions biologiques, y compris la réponse immunitaire. Nous avons étudié un patient ayant une nouvelle mutation ponctuelle hétérozygote dans le gène STAT5B. Les symptômes cliniques majeurs observés chez ce patient sont thrombocytopénie immune (TPI), lymphadenopathies, concentration élevée en anticorps IgM dans le sérum et hypergammaglobulinémie. Nous avons observé une accumulation anormale de lymphocytes T mémoires effecteurs (LME). Une anal
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Bachelez, Hervé. "Analyses moleculaires et fonctionnelles du tcr au cours des lymphoproliferations t cutanees." Paris 7, 1999. http://www.theses.fr/1999PA077017.

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La premiere partie des travaux presentes concerne l'analyse moleculaire de clonalite et l'etude du repertoire des segments variables de la chaine du tcr au cours des lymphomes cutanes epidermotropes (syndrome de sezary et mycosis fongoide). Les etudes de clonalite ont montre l'existence de rearrangements dominants du locus tcrg mis en evidence par pcr, dans une proportion de lesions cutanees analysees qui dependait du stade clinique. Ainsi, alors qu'un clone t unique ou tres predominant etait detecte dans les stades des tumeurs, aucun clone t dominant n'etait identifie dans pres d'un cas sur d
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44

Peixoto, Andreia Liliana da Silva. "Análise da diversidade do repertório do TCR Vß na infecção pelo VIH." Master's thesis, Universidade de Aveiro, 2010. http://hdl.handle.net/10773/3997.

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Mestrado em Biologia Molecular e Celular<br>Um repertório completo do TCR indica uma população de células T intacta, sem alterações, com potencial de reconhecer um vasto número de imunogénios. Durante a infecção primária do VIH, a activação e expansão de células T específicas contra o vírus afecta globalmente o repertório do TCR, causando perturbações ao nível da representação individual de cada família V. A diversidade do repertório TCR V pode ser analisada pelo método Spectratyping. Este método molecular permite detectar expansões clonais no repertório do TCR, através da visualização do
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45

Bethune, Michael T., Marvin H. Gee, Mario Bunse, et al. "Domain-swapped T cell receptors improve the safety of TCR gene therapy." ELIFE SCIENCES PUBLICATIONS LTD, 2016. http://hdl.handle.net/10150/622825.

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T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. We report a general strategy to prevent TCR mispairing: swapping constant domains between the α and β chains of a therapeutic TCR. When paired, domain-swapped (ds)TCRs assemble with CD3, express on the cell surface, and mediate antigen-specific T cell responses. By contrast, dsTCR chains mispaired with endogenous chains cannot properly assemble
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46

Brabb, Thea. "The fate of MBP-specific T cells in MBP TCR transgenic mice /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/10853.

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47

Saini, Manoj. "The role of TCR and cytokine signals in naïve T cell homeostasis." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446076/.

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The peripheral T cell compartment is maintained at a constant size, resulting from a balance of cell development, survival, proliferation and death. Transmission of signals through the TCR and IL-7R on the T cell surface is involved in regulating all these processes, however the precise manner in which these signals together maintain T cell homeostasis is unclear. To investigate the contribution of TCR and IL-7 signals to naive T cell homeostatic responses we established two model systems. To specifically address the role of homeostatic TCR signalling in the development and maintenance of the
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48

Doig, Cassandra Ann. "Development of MHC Class II Tetramer for Detection of Influenza Specific TCR." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579393.

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T cells play a critical role in adaptive immunity by utilizing genetic recombination to produce diverse TCRs that strongly recognize specific antigens. The TCR recognizes peptides presented by APCs via the MHC class II molecules on their surface. The recognition of a specific peptide stimulates the CD4+ T cell to signal downstream processes, which result in the mounting of an antigen specific immune response. With age the available naïve CD8+ T cell pool declines, making the aged population more vulnerable to infections and less responsive to immunotherapies such as vaccines. We hypothesize th
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49

Chouaki-Benmansour, Nassima. "Analyse du rôle des PIP2 dans l'initiation de la signalisation TCR et l'activation lymphocytaire." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4052.

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L'activation des lymphocytes T est un événement fondamental de la réponse immunitaire adaptative. Elle est déclenchée par la transduction du signal médiée par le complexe TCR/CD3.Le mécanisme de déclenchement du signal via le TCR reste, mal compris. Mon projet de thèse vise à examiner la contribution des PI(4,5)P2 dans le mécanisme du déclenchement du signal TCR. L'expression ectopique d'une phosphatase spécifique de PIP2 a permis de réduire de 50% les PI(4,5)P2 membranaires. L'analyse du profil de phosphorylations spécifiques des tyrosines montre que l'expression ectopique de cette 5-phosphat
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50

Carras, Sylvain. "Rôles de la stimulation chronique du TCR et de la reprogrammation cellulaire dans les lymphomes T périphériques." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1322/document.

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Les lymphomes T périphériques (ou PTCL) sont des lymphomes malins non Hodgkiniens ayant pour cellules d’origine des lymphocytes T (LT) ou Natural Killer matures. Ces lymphomes sont rares, hétérogènes et méconnus. Des arguments issus de la littérature suggérant l’implication de la stimulation chronique du récepteur T à l’antigène (TCR) dans la transformation des LT, nous ont conduits à développer un modèle murin basé sur la stimulation chronique du TCR pour adresser spécifiquement cette question. Dans ce modèle, le transfert de LT p53-/- dans des souris CD3e-/- entraine l’apparition de lymphome
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