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Journal articles on the topic 'TCR'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Arty, Indyah Sulistyo. "SYNTHESIZE AND CITOTOXICITY TEST OF SEVERAL COMPOUNDS OF MONO PARA-HIDROXY CHALCON." Indonesian Journal of Chemistry 10, no. 1 (2010): 110–15. http://dx.doi.org/10.22146/ijc.21489.

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Five compounds of mono para-hidroxy chalcon were synthesized (TC1, TC2, TC3, TC4, and TC5) and tested their cytotoxicity against HeLa cell and Raji cell. The difference in substituent of TC1 (R4 =H), TC2 (R4 = OCH3), and TC3 (R4 = F), showed the difference of their citotoxicity against HeLa cell. The citotoxicity of TC1 (LC50 = 16.08 µg/mL) ≈ TC3 (LC50 = 13.37 µg/mL), but the substituent difference of TC2 (LC50 = 147.43 µg/mL), decreasing it citotoxicity 10 times. Like wise their citotoxicity against Raji cell of TC1 (LC50 = 36.44 µg/mL) ≈ TC3 (LC50 = 30.46 µg/mL), but the substituent differen

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2

Uruilal, Costanza, Abraham Talahaturuson, Wihelmina Rumahlewang, and Jogeneis Patty. "ISOLASI Trichoderma spp. DAN DAYA ANTAGONISMENYA TERHADAP SCLEROTIUM ROLFSII SACC. PENYEBAB PENYAKIT LAYU PADA TANAMAN CABAI (Capsicum anuum) SECARA IN-VITRO." JURNAL BUDIDAYA PERTANIAN 13, no. 2 (2017): 64–67. http://dx.doi.org/10.30598/jbdp.2017.13.2.64.

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The objective of this study is to isolation and agonistic test ability of Trichoderma spp. againts Sclerotium rolfsii Sacc. cause of wilting on pepper plants and has been conducted in Pathogenicity Laboratory Faculty of Agriculture Unpatti. The study use 5 treatment of isolate Trichoderma spp. (Tc3, Tc4, Tc5, Tc6 and Tc7) with 3 replications so that there are 15 experimental units. The results showed that the five isolates Trichoderma spp. has an antagonistic power to S. rolfsii with an average percentage of inhibition of S. rolfsii of 26,01%. Percentage of inhibition bolth of isolate ware not

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3

Bagot, Martine, Hamid Echchakir, Fathia Mami-Chouaib, et al. "Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma." Blood 91, no. 11 (1998): 4331–41. http://dx.doi.org/10.1182/blood.v91.11.4331.

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Abstract We have isolated several T-cell clones from lymphocytes infiltrating a human major histocompatibility class (MHC) II negative cutaneous T-cell lymphoma (CTCL). We describe here two of these clones, TC5 and TC7, with, respectively, a CD4+CD8dim+ and CD4+CD8− phenotype. Both clones mediated a specific MHC class I–restricted cytotoxic activity toward the fresh autologous tumor cells, and autologous tumor cell lines previously established with interleukin-2 (IL-2) and IL-7 from the skin and from the blood. Analysis of the T-cell receptor (TCR) Vβ gene expression showed that the tumor cell

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Bagot, Martine, Hamid Echchakir, Fathia Mami-Chouaib, et al. "Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma." Blood 91, no. 11 (1998): 4331–41. http://dx.doi.org/10.1182/blood.v91.11.4331.411k12_4331_4341.

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We have isolated several T-cell clones from lymphocytes infiltrating a human major histocompatibility class (MHC) II negative cutaneous T-cell lymphoma (CTCL). We describe here two of these clones, TC5 and TC7, with, respectively, a CD4+CD8dim+ and CD4+CD8− phenotype. Both clones mediated a specific MHC class I–restricted cytotoxic activity toward the fresh autologous tumor cells, and autologous tumor cell lines previously established with interleukin-2 (IL-2) and IL-7 from the skin and from the blood. Analysis of the T-cell receptor (TCR) Vβ gene expression showed that the tumor cells, which

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5

Goux, Delphine, Jérôme D. Coudert, Diane Maurice, et al. "Cooperating pre–T-cell receptor and TCF-1–dependent signals ensure thymocyte survival." Blood 106, no. 5 (2005): 1726–33. http://dx.doi.org/10.1182/blood-2005-01-0337.

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Abstract Intrathymic T-cell maturation critically depends on the selective expansion of thymocytes expressing a functionally rearranged T-cell receptor (TCR) β chain. In addition, TCR-independent signals also contribute to normal T-cell development. It is unclear whether and how signals from the 2 types of pathways are integrated. Here, we show that T-cell factor-1 (TCF-1), a nuclear effector of the canonical wingless/int (wnt)/catenin signaling pathway, ensures the survival of proliferating, pre-TCR+ thymocytes. The survival of pre-TCR+ thymocytes requires the presence of the N-terminal caten

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6

Ciurea, Stefan O., Rima M. Saliba, Ulas D. Bayraktar, et al. "Improved Early Outcomes with T-Cell Replete (TCR) Compared with T-Cell Depleted (TCD) Haploidentical Stem Cell Transplantation (HaploSCT)." Blood 118, no. 21 (2011): 320. http://dx.doi.org/10.1182/blood.v118.21.320.320.

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Abstract Abstract 320 Background: HaploSCT has been commonly performed with a TCD graft using CD34+ selection; however, this has been limited by a higher non-relapse mortality (NRM) primarily related to infectious complications. An alternative approach using a TCR bone marrow graft and high-dose post-transplant cyclophosphamide (HDPTCy) in the setting of non-myeloablative conditioning has been reported to have lower NRM and acceptable rates of GVHD. Methods: We hypothesized that TCR HaploSCT using HDPTCy is associated with improved immunologic reconstitution, less NRM and better early outcomes

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7

Delea, Thomas, Aaron Moynahan, Wenzhen Ge, et al. "Real-World Study of Patients with Triple-Class Exposed Relapsed/Refractory Multiple Myeloma: Analysis across a Spectrum of Advanced Disease Stage Medicare Patients in the United States." Blood 142, Supplement 1 (2023): 3773. http://dx.doi.org/10.1182/blood-2023-188591.

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Background Treatment of relapsed/refractory (RR) multiple myeloma (MM) has been transformed by novel therapies including anti-CD38 monoclonal antibodies (mAb), 2 nd and 3 rd generation immunomodulatory drugs (IMiD), and proteasome inhibitors (PI). This has resulted in increasing numbers (no.) of triple-class exposed (TCE) patients (pts), defined as pts who have received an IMiD, ≥1 PI, and ≥1 anti-CD38 mAb. Many TCE pts are exposed to ≥5 drugs in these classes (i.e. penta-exposed [PE]: ≥2 IMID, ≥2 PI, and an anti-CD38 mAb). Some are refractory to ≥1 drug in each class (triple-class refractory

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8

Sun, Hanli, Jiao Huang, Kai Zhan, et al. "Abstract 3598: A new strategy for T cell therapy: T cells secreting TCR anti-CD3 bispecific T-cell engager." Cancer Research 84, no. 6_Supplement (2024): 3598. http://dx.doi.org/10.1158/1538-7445.am2024-3598.

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Abstract TCR-engineered T (TCR-T) cells and TCR-anti-CD3 bispecific T-cell engagers (TCEs) are potent TCR-based therapeutic agents with distinct advantages and limitations in tumor treatment. TCR-T cells offer durable persistence within patients but necessitate personalized manufacturing and lack the capacity to harness bystander T cells. Conversely, TCEs are readily available as "off-the-shelf" products and can recruit bystander T cells, yet they exhibit a shorter lifespan. In our study, we sought to merge the merits of both approaches by engineering T cells to secrete a TCR-anti-CD3 TCE spec

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9

Abdulazim, Amr, Nora Prochnow, and Tara Taeihagh. "TCR or Not TCR?" Journal of Oral and Maxillofacial Surgery 69, no. 10 (2011): 2483–84. http://dx.doi.org/10.1016/j.joms.2011.05.028.

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10

Oros-Ortega, Iván, Alejandro Alonso-López, Jesús Pérez-Moreno, et al. "Respuesta de plántulas de Cedrela odorata a la inoculación con Rhizophagus intraradices y diferentes niveles de defoliación." Revista Mexicana de Ciencias Agrícolas 6, no. 3 (2017): 627. http://dx.doi.org/10.29312/remexca.v6i3.645.

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   Respuesta de plántulas de Cedrela odorata a la inoculación con Rhizophagus intraradices y diferentes niveles de defoliación ; el efecto de seis tratamientos (T) sobre la tasa de crecimiento en altura (TCA) , diámetro ( TCD ) , tasa de crecimiento relativo (TCR ) y peso fresco y seco de plántulas de C. odorata se evaluaron en un vivero. Se utilizó un diseño completamente al azar con arreglo factorial (2 x 3); TS consistió en una combinación de los factores: porcentaje de defoliación (0, 50 y 90) y la inoculación de R. intraradices (con y sin inoculación). Despue

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Blazar, BR, PA Taylor, JA Bluestone, and DA Vallera. "Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens." Blood 87, no. 10 (1996): 4463–72. http://dx.doi.org/10.1182/blood.v87.10.4463.bloodjournal87104463.

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T cells with antidonor specificities have been isolated from human recipients experiencing graft rejection after allogeneic bone marrow transplantation (BMT). Partial T-cell depletion of unrelated BM grafts with an anti- T-cell receptor (TCR) monoclonal antibody (MoAb) directed against the TCR alpha/beta heterodimer have shown that the incidence of graft-versus-host disease is low and that the incidence of durable engraftment is high. These studies suggest either that the number of residual TCR alpha/beta+ cells was sufficient to permit alloengraftment or that the preservation of cells other t

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12

Kozovska, M. F., T. Yamamura, and T. Tabira. "T-T cellular interaction between CD4-CD8- regulatory T cells and T cell clones presenting TCR peptide. Its implication for TCR vaccination against experimental autoimmune encephalomyelitis." Journal of Immunology 157, no. 4 (1996): 1781–90. http://dx.doi.org/10.4049/jimmunol.157.4.1781.

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Abstract Regulatory T cells recognizing TCR determinants presumably play a critical role in the control of experimental autoimmune encephalomyelitis, a prototype tissue-specific autoimmune disease. This study was initiated to determine whether regulatory T cells can be induced against a V beta 17a CDR2 peptide (residues 50-68) in SJL/J mice. Although the TCR peptide showed regulatory effects in vivo, the presence of T cells specific for the peptide could not be proven with conventional proliferation assays. Unexpectedly, in the presence of myelin basic protein-specific T clone cells (Tcc), the

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13

Hohmann, Uwe, Winfried Busch, Katia Badaeva, Bernd Friebe, and Bikram S. Gill. "Molecular cytogenetic analysis of Agropyron chromatin specifying resistance to barley yellow dwarf virus in wheat." Genome 39, no. 2 (1996): 336–47. http://dx.doi.org/10.1139/g96-044.

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Nine families of bread wheat (TC5, TC6, TC7, TC8, TC9, TC10, TC14, 5395-(243AA), and 5395) with resistance to barley yellow dwarf virus and containing putative translocations between wheat and a group 7 chromosome of Agropyron intermedium (L1 disomic addition line, 7Ai#1 chromosome) induced by homoeologous pairing or tissue culture were analyzed. C-banding, genomic in situ hybridization (GISH), and restriction fragment length polymorphism (RFLP) in combination with repetitive Agropyron-specific sequences and deletion mapping in wheat were used to determine the relative locations of the translo

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14

Dilchert, Janine, Martin Hofmann, Felix Unverdorben, Roland Kontermann, and Sebastian Bunk. "Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules." Antibodies 11, no. 2 (2022): 34. http://dx.doi.org/10.3390/antib11020034.

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Bispecific T cell receptor (TCR)-based molecules capable of redirecting and activating T cells towards tumor cells represent a novel and promising class of biotherapeutics for the treatment of cancer. Usage of TCRs allows for targeting of intracellularly expressed and highly selective cancer antigens, but also requires a complex maturation process to increase the naturally low affinity and stability of TCRs. Even though TCR domains can be matured via phage and yeast display, these techniques share the disadvantages of non-human glycosylation patterns and the need for a later reformatting into

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15

Eyrich, Matthias, Tanja Croner, Christine Leiler, et al. "Distinct contributions of CD4+ and CD8+naive and memory T-cell subsets to overall T-cell–receptor repertoire complexity following transplantation of T-cell–depleted CD34-selected hematopoietic progenitor cells from unrelated donors." Blood 100, no. 5 (2002): 1915–18. http://dx.doi.org/10.1182/blood-2001-11-0005.

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Normalization of restricted T-cell–receptor (TCR) repertoire is critical following T-cell–depleted (TCD) stem cell transplantation. We present a prospective study analyzing respective contributions of naive and memory T-cell subsets within the CD4+ and CD8+ compartments to the evolution of overall TCR-repertoire complexity following transplantation of CD34-selected peripheral blood progenitor cells from unrelated donors. During the first year after transplantation, sorted CD4/45RA, CD4/45R0, CD8/45RA, and CD8/45R0 subsets were analyzed at 3-month intervals for TCR-repertoire complexity by CDR3

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von Greyerz, Salome, Martin P. Zanni, Karin Frutig, Benno Schnyder, Christoph Burkhart та Werner J. Pichler. "Interaction of Sulfonamide Derivatives with the TCR of Sulfamethoxazole-Specific Human αβ+ T Cell Clones". Journal of Immunology 162, № 1 (1999): 595–602. http://dx.doi.org/10.4049/jimmunol.162.1.595.

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Abstract Drugs like sulfamethoxazole (SMX) or lidocaine can be presented to specific human αβ+ T cell clones (TCC) by undergoing a noncovalent association with MHC-peptide complexes on HLA-matched APCs. For a better understanding of the molecular basis of the recognition of such drugs by specific TCC, we investigated 1) the fine specificity of the recognizing TCR, 2) the dose-response relationship for the induction of proliferation or cytokine production, and 3) the mechanism of TCR triggering. For that purpose, we tested the reactivity of 11 SMX-specific CD4+ TCC and 2 SMX-specific CD8+ TCC t

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Cieslak, Cassandra, Carsten Hain, Christian Rückert-Reed, et al. "Nanopore Sequencing for T-Cell Receptor Rearrangement Analysis in Cutaneous T-Cell Lymphoma." Cancers 16, no. 21 (2024): 3700. http://dx.doi.org/10.3390/cancers16213700.

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Background: Analysis of T-cell receptor (TCR) clonality is a major diagnostic tool for lymphomas, particularly for cutaneous T-cell lymphomas (CTCL) like Mycosis fungoides and Sézary syndrome. However, a fast and cost-effective workflow is needed to enable widespread use of this method. Methods: We established a procedure for TCR rearrangement analysis via Oxford Nanopore Technology (ONT) sequencing. TCR receptor rearrangements (TCR-gamma and TCR-beta chains) were analyzed in samples from 45 patients with various diagnoses: Mycosis fungoides (37/45), Sézary Syndrome (2/45), folliculotropic CTC

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Stasi, Antonio Di, LM Poon, Roberto Ferro, et al. "Transplant Outcomes For Patients With AML/MDS Using Melphalan-Based Conditioning." Blood 122, no. 21 (2013): 2167. http://dx.doi.org/10.1182/blood.v122.21.2167.2167.

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Abstract Introduction Haploidentical stem cell transplant (haplo-HCT) is a therapeutic option for patients without matched donors. We aimed to analyze outcomes of patients with AML/MDS treated with melphalan-based conditioning and different donors at our institution and determine the factors associated with survival. Methods All 246 patients receiving an allograft for AML/MDS between 01/2005 and 09/2012 were included in this retrospective analysis. Conditioning regimen consisted of melphalan 100 mg/m2 (Mel100) (N=37) or 140 mg/m2, (Mel140) (N=209) and fludarabine 120-240 mg/m2 +/- thiotepa (N=

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Halverson, David C., Gretchen N. Schwartz, Charles Carter, Ronald E. Gress, and Daniel H. Fowler. "In Vitro Generation of Allospecific Human CD8+ T Cells of Tc1 and Tc2 Phenotype." Blood 90, no. 5 (1997): 2089–96. http://dx.doi.org/10.1182/blood.v90.5.2089.

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Abstract We have previously shown that allospecific murine CD8+ T cells of the Tc1 and Tc2 phenotype could be generated in vitro, and that such functionally defined T-cell subsets mediated a graft-versus-leukemia (GVL) effect with reduced graft-versus-host disease (GVHD). To evaluate whether analogous Tc1 and Tc2 subsets might be generated in humans, CD8+ T cells were allostimulated in the presence of either interleukin-12 (IL-12) and transforming growth factor-beta (TGF-β) (Tc1 culture) or IL-4 (Tc2 culture). Tc1-type CD8 cells secreted the type I cytokines IL-2 and interferon gamma (IFN-γ),

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Lan, Xin, Tian Mi, and Ben A. Youngblood. "Exhausted CD8 T cell progenitors are sustained with TCR engagement during anti-tumor responses." Journal of Immunology 210, no. 1_Supplement (2023): 171.12. http://dx.doi.org/10.4049/jimmunol.210.supp.171.12.

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Abstract T cell exhaustion is a major contributor to tumor immune invasion. The durability of an anti-tumor response is in part determined by the persistence of exhausted CD8 T cell progenitors (Tpex) that reconstitute the effector T cell pool. While it has been reported that Tpex are able to survive without antigen, the role of TCR engagement in regulating Tpex self-renewal during tumor progression remains to be fully explored. Here, we used a Lewis lung carcinoma model where a robust or dampened TCR signal was elicited resulting in bona fide tumor-infiltrating Tpex. Longitudinal analysis of

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Werfel, T., M. Hentschel, A. Kapp, and H. Renz. "Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T cells and restricted V beta repertoire in nickel-mediated contact dermatitis." Journal of Immunology 158, no. 5 (1997): 2500–2505. http://dx.doi.org/10.4049/jimmunol.158.5.2500.

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Abstract In this study we compared the phenotype and cytokine patterns of nickel-specific T cell clones (TCC) derived from blood samples and positive patch test reactions. A total of 252 nickel-specific TCC were established from three nonatopic patients with allergic contact dermatitis caused by nickel. All TCC expressed the TCR-alpha beta, and 77% were CD4+ compared with 21% CD8+ TCC. In contrast to blood-derived TCC, the majority of skin-derived CD4+ or CD8+ T lymphocytes produced IL-4 either in combination with IFN-gamma (type 0 cytokine pattern) or IL-4 exclusively (type 2 pattern). Skin-d

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Turtle, Cameron J., Jeff Delrow, Rochelle C. Joslyn та ін. "Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161hi CD8α+ semi-invariant T cells". Blood 118, № 10 (2011): 2752–62. http://dx.doi.org/10.1182/blood-2011-02-334698.

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Abstract Type 17 programmed CD161hiCD8α+ T cells contribute to mucosal immunity to bacteria and yeast. In early life, microbial colonization induces proliferation of CD161hi cells that is dependent on their expression of a semi-invariant Vα7.2+ TCR. Although prevalent in adults, CD161hiCD8α+ cells exhibit weak proliferative and cytokine responses to TCR ligation. The mechanisms responsible for the dichotomous response of neonatal and adult CD161hi cells, and the signals that enable their effector function, have not been established. We describe acquired regulation of TCR signaling in adult mem

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Migdał-Mikuli, Anna, and Elżbieta Szostak. "Phase Polymorphism of [Mn(DMSO)6](ClO4)2 Studied by Differential Scanning Calorimetry." Zeitschrift für Naturforschung A 60, no. 4 (2005): 289–95. http://dx.doi.org/10.1515/zna-2005-0413.

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Abstract Six solid phases of [Mn(DMSO)6](ClO4)2 have been detected by differential scanning calorimetry. The phase transitions were found between the following solid phases: stable KIc ↔ stable KIb at TC5 = 225 K, metastable KIII ↔ metastable KII at TC4 = 322 K, stable KIb ↔ stable KIa at TC3 = 365 K, metastable KII↔overcooled K0 at TC2 = 376 K and stable KIa→stable K0 at TC1 = 379 K. The title compound melts at Tm = 488 K.

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Li, Kai, Yue Zhuo, Yue He, et al. "T cell receptor repertoire as a novel indicator for identification and immune surveillance of patients with severe obstructive sleep apnea." PeerJ 11 (April 7, 2023): e15009. http://dx.doi.org/10.7717/peerj.15009.

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Background Obstructive sleep apnea (OSA) is the most prevalent sleep disturbance that affects approximately 936 million people worldwide and leads to extensively increased incidence of cardiovascular disease, metabolic syndrome, neurological disorders, and traffic accidents. Severe OSA patients suffer a significantly higher risk of complications and worse comorbidity outcomes. Notwithstanding, with inadequate access to contact diagnosis based on polysomnography (PSG), numerous patients with severe sleep apnea have not been diagnosed, especially during the pandemic. Moreover, how the T cell imm

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Li, Sheng-You, Ze-Kun Sun, Xue-Yi Zeng, et al. "Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis." Molecules 24, no. 22 (2019): 4138. http://dx.doi.org/10.3390/molecules24224138.

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Twenty-seven L-shaped ortho-quinone analogs were designed and synthesized using a one pot double-radical synthetic strategy followed by removing methyl at C-3 of the furan ring and introducing a diverse side chain at C-2 of the furan ring. The synthetic derivatives were investigated for their cytotoxicity activities against human leukemia cells K562, prostate cancer cells PC3, and melanoma cells WM9. Compounds TB1, TB3, TB4, TB6, TC1, TC3, TC5, TC9, TC11, TC12, TC14, TC15, TC16, and TC17 exhibited a better broad-spectrum cytotoxicity on three cancer cells. TB7 and TC7 selectively displayed pot

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Messier, H., H. Brickner, J. Gaikwad, and A. Fotedar. "A novel POU domain protein which binds to the T-cell receptor beta enhancer." Molecular and Cellular Biology 13, no. 9 (1993): 5450–60. http://dx.doi.org/10.1128/mcb.13.9.5450-5460.1993.

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POU domain proteins have been implicated in the regulation of a number of lineage-specific genes. Among the first POU domain proteins described were the immunoglobulin octamer-binding proteins Oct-1 and Oct-2. It was therefore of special interest when we identified a novel lymphoid POU domain protein in Southwestern (DNA-protein) screens of T-cell lambda gt11 libraries. This novel POU protein, TCF beta 1, binds in a sequence-specific manner to a critical motif in the T-cell receptor (TCR) beta enhancer. Sequence analysis revealed that TCF beta 1 represents a new class of POU domain proteins wh

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Messier, H., H. Brickner, J. Gaikwad, and A. Fotedar. "A novel POU domain protein which binds to the T-cell receptor beta enhancer." Molecular and Cellular Biology 13, no. 9 (1993): 5450–60. http://dx.doi.org/10.1128/mcb.13.9.5450.

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POU domain proteins have been implicated in the regulation of a number of lineage-specific genes. Among the first POU domain proteins described were the immunoglobulin octamer-binding proteins Oct-1 and Oct-2. It was therefore of special interest when we identified a novel lymphoid POU domain protein in Southwestern (DNA-protein) screens of T-cell lambda gt11 libraries. This novel POU protein, TCF beta 1, binds in a sequence-specific manner to a critical motif in the T-cell receptor (TCR) beta enhancer. Sequence analysis revealed that TCF beta 1 represents a new class of POU domain proteins wh

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Ajani, Emmanuel Kolawole, Olugbenga Orisasona, Oladeji Kazeem Kareem, et al. "Growth Performance, Gut Ecology, Immunocompetence and Resistance of Oreochromis niloticus Juveniles Fed Dietary Curcumin longa." Croatian Journal of Fisheries 78, no. 3 (2020): 145–56. http://dx.doi.org/10.2478/cjf-2020-0014.

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AbstractThe growth, gut ecology and immunocompetence of Oreochromis niloticus and the resistance to Aeromonas hydrophila were investigated after been fed with diets containing dietary Curcumin longa for 12 weeks. Diets were formulated to contain 30% crude protein with diet TC1, TC2, TC3, TC4 and TC5 having 0% (control), 0.25%, 0.5%, 0.75% and 1.0% turmeric powder, respectively. Diets were allotted to groups of O. niloticus (mean weight of 1.29± 0.15 g) and replicated thrice for 84 days. Results showed that the highest mean final weight (4.79±0.04 g) was obtained in TC3 and corresponded to the

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Van de Wetering, M., J. Castrop, V. Korinek, and H. Clevers. "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties." Molecular and Cellular Biology 16, no. 3 (1996): 745–52. http://dx.doi.org/10.1128/mcb.16.3.745.

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Previously, we reported the isolation of cDNA clones representing four alternative splice forms of TCF-1, a T-cell-specific transcription factor. In the present study, Western blotting (immunoblotting) yielded a multitude of TCF-1 proteins ranging from 25-55 kDa, a pattern not simply explained from the known splice alternatives. Subsequent cDNA cloning, PCR amplification, and analysis by rapid amplification of 5' cDNA ends revealed (i) the presence of an alternative upstream promoter, which extended the known N terminus by 116 amino acids, (ii) the presence of four alternative exons, and (iii)

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Trop, Sébastien, Michele Rhodes, David L. Wiest, Patrice Hugo та Juan Carlos Zúñiga-Pflücker. "Competitive Displacement of pTα by TCR-α During TCR Assembly Prevents Surface Coexpression of Pre-TCR and αβ TCR". Journal of Immunology 165, № 10 (2000): 5566–72. http://dx.doi.org/10.4049/jimmunol.165.10.5566.

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Li, Yiming, Wenbin Zhao, Ying Shen, Yingchun Xu, Shuqing Chen, and Liqiang Pan. "T Cell Receptor-Directed Bispecific T Cell Engager Targeting MHC-Linked NY-ESO-1 for Tumor Immunotherapy." Biomedicines 12, no. 4 (2024): 776. http://dx.doi.org/10.3390/biomedicines12040776.

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Antibody-based bispecific T cell engagers (TCEs) that redirect T cells to kill tumor cells have shown a promising therapeutic effect on hematologic malignancies. However, tumor-specific targeting is still a challenge for TCEs, impeding the development of TCEs for solid tumor therapy. The major histocompatibility complex (MHC) presents almost all intracellular peptides (including tumor-specific peptides) on the cell surface to be scanned by the TCR on T cells. With the premise of choosing optimal peptides, the final complex peptide–MHC could be the tumor-specific target for TCEs. Here, a novel

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Vantellini, Alessio, Nora Wettstein, Melissa Vrohlings, et al. "Abstract 3494: Durable and potent in vitro T cell activity with repeated exposure to CDR404, a potential best-in-class T cell engager targeting MAGE-A4." Cancer Research 85, no. 8_Supplement_1 (2025): 3494. https://doi.org/10.1158/1538-7445.am2025-3494.

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Abstract T cell engagers (TCEs) targeting the melanoma antigen gene A4 (MAGE-A4) have entered first-in-human trials for HLA-A*02:01+ patients with MAGE-A4 expressing solid tumors. CDR404 is a bispecific antibody-based TCE that binds bivalently to the MAGE-A4230-239 peptide on HLA-A*02:01 and monovalently to CD3. The safety, tolerability and preliminary therapeutic efficacy of CDR404 are currently being evaluated in a dose-finding Phase 1 trial in multiple solid cancers including NSCLC (NCT06402201). The only other MAGE-A4 targeting TCE currently in clinical trial is a TCR-based TCE with a low

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Bariana, Manpreet, Mark Batistick, Mathias Oelke, et al. "Ex Vivo Enriched Tumor Antigen-Specific T Cells Are Optimal Effectors of T Cell Engagers and Tumor-Specific T Cell Receptor/T Cell Engager Combination Provides Synergistic Efficacy Against Hematologic Malignancies." Blood 142, Supplement 1 (2023): 2056. http://dx.doi.org/10.1182/blood-2023-179342.

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Multiple myeloma (MM) and acute myeloid leukemia (AML) are blood cancers that remain difficult to treat because a large proportion of patients have disease that does not respond to currently available therapies. NexImmune's Artificial Immune Modulation (AIM) platform mimics natural dendritic cell function by using nanoparticles engineered with MHC molecules loaded with tumor specific peptides (signal 1) and anti-CD28 (signal 2) for activation and expansion of HLA A*02:01 restricted tumor associated antigen (TAA)-specific cytotoxic CD8 T lymphocytes (CTL). Additionally, T cell engager (TCE) the

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Dempsey, Laurie A. "TCR tuning." Nature Immunology 13, no. 6 (2012): 533. http://dx.doi.org/10.1038/ni.2335.

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Bell, Elaine. "TCR docking." Nature Reviews Immunology 2, no. 9 (2002): 626. http://dx.doi.org/10.1038/nri898.

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Jones, Daniel S., Peter Reichardt, Mandy L. Ford, Lindsay J. Edwards, and Brian D. Evavold. "TCR Antagonism by Peptide Requires High TCR Expression." Journal of Immunology 181, no. 3 (2008): 1760–66. http://dx.doi.org/10.4049/jimmunol.181.3.1760.

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Sasmal, Dibyendu K., Wei Feng, Sobhan Roy, et al. "TCR–pMHC bond conformation controls TCR ligand discrimination." Cellular & Molecular Immunology 17, no. 3 (2019): 203–17. http://dx.doi.org/10.1038/s41423-019-0273-6.

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Abstract A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζ receptors at the membranes of live primary T cells. We found that a TCR discriminates between closely related peptides by forming single TCR–pMHC bonds with different conformations, and the most potent pMHC forms the shortest bond. The bond conformation is an intrinsic property that is independent of the bin

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Huang, Jun, and Dibyendu K. Sasmal. "TCR-pMHC bond length controls TCR ligand discrimination." Journal of Immunology 202, no. 1_Supplement (2019): 184.10. http://dx.doi.org/10.4049/jimmunol.202.supp.184.10.

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Abstract T-cell receptors (TCRs) detect specifically and sensitively a small number of agonist peptide-major histocompatibility complexes (pMHCs) from an ocean of structurally similar self-pMHCs to trigger antigen-specific adaptive immune responses. Despite intense efforts, the mechanism underlying TCR ligand discrimination remains a major unanswered question in immunology. Here we show that a TCR discriminates between closely related peptides by forming TCR-pMHC bonds with different lengths, which precisely control the accessibility of CD3ζ immunoreceptor tyrosine-based activation motifs (ITA

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Wu, Ying, Maxwell Spurrell, Songyan Deng, and Kevan Herold. "Single-cell transcriptomics of CD8 T cells in autoimmune diabetes after anti-CD3 monoclonal antibody treatment." Journal of Immunology 212, no. 1_Supplement (2024): 0998_4625. http://dx.doi.org/10.4049/jimmunol.212.supp.0998.4625.

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Abstract The FcR non-binding anti-CD3 mAb, teplizumab is the first drug approved by FDA to delay Type 1 diabetes (T1D) by modulating the immune mediated destruction of insulin-producing β cells. However, we and others have observed that after remission is induced in diabetic NOD mice that are treated with F(ab’)2 fragments of mAb 145-2C11, insulitis remains. To understand how the antibody induces long-term tolerance, we performed single-cell RNA-seq and TCR-seq on T cells from the islets and pancreas-draining lymph nodes (pLN) of long-term remitted NOD mice treated by anti-CD3 mAb or pre-diabe

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O’Rourke, John, Andrea Gomez-Donart, Caroline Weldon, and Zhaoping Liu. "Developing a novel multiplexed high throughput flow cytometry based immune assay to screen kinase modulators of primary T cell activation." Journal of Immunology 202, no. 1_Supplement (2019): 131.7. http://dx.doi.org/10.4049/jimmunol.202.supp.131.7.

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Abstract Modulating TCR engagement and signaling using biologics, small molecules or genetic engineering is highly relevant to many therapeutic areas. TCR signal initiation is mediated by cytosolic tyrosine kinases, leading to signal amplification through a network of serine-threonine kinases. Genetic defects, mutations and other mechanisms leading to increased kinase activity and enhanced T cell activation (TCA) is involved in many autoimmune pathologies, making kinases attractive targets for the direct inhibition of TCA and treatment of autoimmune disease. The development of drugs and therap

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Punt, J. A., J. L. Roberts, K. P. Kearse, and A. Singer. "Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains." Journal of Experimental Medicine 180, no. 2 (1994): 587–93. http://dx.doi.org/10.1084/jem.180.2.587.

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The stoichiometry of the subunits that comprise the T cell antigen receptor (TCR) complex is not completely known. In particular, it is uncertain whether TCR alpha and TCR beta proteins are present in the TCR complex as one or multiple heterodimeric pairs. In this study we have used mice transgenic for two different TCR alpha and two different TCR beta proteins to determine the number of TCR alpha and TCR beta chains in a single TCR complex. Individual thymocytes and splenic T cells from double TCR transgenic mice simultaneously expressed all four transgenic TCR proteins on their surfaces. Bec

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Kinebuchi, M., A. Matsuura, T. Ogiu, and K. Kikuchi. "Deviated overexpression of TCR-beta, TCR-gamma, CD4, and CD8 on thymic lymphomas induced by 1-propyl-1-nitrosourea: destruction of the allelic exclusion of TCR-beta and expression of functional TCR-betagamma heterodimer on a lymphoma, cFTL53." Journal of Immunology 159, no. 2 (1997): 748–56. http://dx.doi.org/10.4049/jimmunol.159.2.748.

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Abstract Thymic lymphomas (FTLs) induced by the chemical carcinogen 1-propyl-1-nitrosourea (PNU) in F344 rats showed deviated overexpression of TCR-beta, TCR-gamma, CD4, and CD8. Even though most FTLs were in the CD4+ CD8+ stage, all FTLs expressed TCR-beta mRNA with TCR-gamma mRNA, but without TCR-alpha mRNA or TCR-delta mRNA. One of the FTLs, cFTL53, expressed two kinds of TCR-beta mRNA and two kinds of TCR-gamma mRNA, but did not express any mRNA of TCR-alpha or TCR-delta. Both alleles of TCR-beta loci were rearranged on cFTL53. cDNA cloning and sequencing analysis showed that one TCR-gamma

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Buer, Jan, Iannis Aifantis, James P. DiSanto, Hans Joerg Fehling, and Harald von Boehmer. "Role of Different T Cell Receptors in the Development of Pre–T Cells." Journal of Experimental Medicine 185, no. 9 (1997): 1541–48. http://dx.doi.org/10.1084/jem.185.9.1541.

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The development of pre–T cells with productive TCR-β rearrangements can be mediated by each the pre–T cell receptor (pre-TCR), the TCR-αβ as well as the TCR-γδ, albeit by distinct mechanisms. Although the TCR-γδ affects CD4−8− precursor cells irrespective of their rearrangement status by TCR-β mechanisms not involving TCR-β selection, both the preTCR and the TCR-αβ select only cells with productive TCR-β genes for expansion and maturation. The TCR-αβ appears to be much less effective than the pre-TCR because of the paucity of TCR-α proteins in TCR-β–positive precursors since an early expressed

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Yokosuka, Tadashi, Kan Takase, Misao Suzuki та ін. "Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System". Journal of Experimental Medicine 195, № 8 (2002): 991–1001. http://dx.doi.org/10.1084/jem.20010809.

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The CDR3 regions of T cell receptor (TCR)-α and -β chains play central roles in the recognition of antigen (Ag)-MHC complex. TCR repertoire is created on the basis of Ag recognition specificity by CDR3s. To analyze the potential spectrum of TCR-α and -β to exhibit Ag specificity and generate TCR repertoire, we established hundreds of TCR transfectants bearing a single TCR-α or -β chain derived from a cytotoxic T cell (CTL) clone, RT-1, specific for HIVgp160 peptide, and randomly picked up TCR-β or -α chains. Surprisingly, one-third of such TCR-β containing random CDR3β from naive T cells of no

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Zaleski, J., G. Bator, and R. Jakubas. "Dielectric Properties and Characterisation of the Superionic Phase of [C(NH2)3]2SbCl5*[C(NH2)3]Cl (GHCA)." Zeitschrift für Naturforschung A 50, no. 9 (1995): 888–92. http://dx.doi.org/10.1515/zna-1995-0916.

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GHCA undergoes four phase transitions at Tc1 = 402 K, Tc2 = 373 K, Tc3 = 162 K, and Tc4 = 146 K. Below Tc3 it possesses pyroelectric properties with the spontaneous polarization vector (Ps) in the ac plane and the maximum along the c axis equal to 8 μC/m2. Dielectric dispersion studies of GHCA show that the main dielectric dispersion connected probably with collective motions of chlorine ions is above 1GHz. For the phase transition at Tc2 to a superionic phase the thermal dilatation and electric conductivity were measured. The anomalies of the electric conductivity at Tc2 and Tc1 were observed

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van Dongen, JJ, IL Wolvers-Tettero, F. Wassenaar, J. Borst, and P. van den Elsen. "Rearrangement and expression of T-cell receptor delta genes in T-cell acute lymphoblastic leukemias." Blood 74, no. 1 (1989): 334–42. http://dx.doi.org/10.1182/blood.v74.1.334.334.

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Abstract We have analyzed T-cell receptor delta (TcR-delta) gene rearrangement and transcription in appropriately phenotyped mononuclear cells derived from 12 patients with T-cell acute lymphoblastic leukemia (T-ALL). The T-ALL cells were also analyzed for rearrangement and transcription of the T-cell receptor(TcR)-beta and gamma genes as well as for the presence of TcR-alpha gene transcripts. Four T-ALLs expressed TcR-gamma delta at the cell surface, while three expressed TcR-alpha beta. The other five T-ALLs did not express a TcR-CD3 complex on their cell membrane. The TcR-gamma delta + T-AL

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van Dongen, JJ, IL Wolvers-Tettero, F. Wassenaar, J. Borst, and P. van den Elsen. "Rearrangement and expression of T-cell receptor delta genes in T-cell acute lymphoblastic leukemias." Blood 74, no. 1 (1989): 334–42. http://dx.doi.org/10.1182/blood.v74.1.334.bloodjournal741334.

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We have analyzed T-cell receptor delta (TcR-delta) gene rearrangement and transcription in appropriately phenotyped mononuclear cells derived from 12 patients with T-cell acute lymphoblastic leukemia (T-ALL). The T-ALL cells were also analyzed for rearrangement and transcription of the T-cell receptor(TcR)-beta and gamma genes as well as for the presence of TcR-alpha gene transcripts. Four T-ALLs expressed TcR-gamma delta at the cell surface, while three expressed TcR-alpha beta. The other five T-ALLs did not express a TcR-CD3 complex on their cell membrane. The TcR-gamma delta + T-ALL had rea

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Silva, Paulo Igor Barbosa e., Maria Zuleide de Negreiros, Karidja Kalliany Carlos de Freitas Moura, et al. "Crescimento de pimentão em diferentes arranjos espaciais." Pesquisa Agropecuária Brasileira 45, no. 2 (2010): 132–39. http://dx.doi.org/10.1590/s0100-204x2010000200003.

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O objetivo deste trabalho foi avaliar o crescimento do pimentão cv. Atlantis sob diferentes arranjos espaciais. Foram avaliados três arranjos de espaçamentos entre fileiras duplas e fileiras simples de plantio (1,5x0,5, 1,6x0,4 e 1,7x0,3 m), e quatro espaçamentos entre plantas nas fileiras (0,2, 0,3, 0,4 e 0,5 m), combinados em esquema fatorial. Utilizou-se o delineamento de blocos ao acaso, com três repetições e parcelas subdivididas no tempo. A avaliação de crescimento foi realizada em nove épocas espaçadas em 14 dias, com a primeira avaliação realizada 14 dias após o transplantio (DAT). Até

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Makazlieva, Tanja, Olivija Vaskova, Toni Tripunoski, et al. "Thyroid Stimulating Hormone Receptor Transcripts in Correlation with Clinical Parameters in Thyroid Carcinoma Patients." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 866–72. http://dx.doi.org/10.3889/oamjms.2020.5099.

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BACKGROUND: Differentiated thyroid carcinomas (DTC) preserve expression of thyroid stimulating hormone receptor (TSHR). AIM: The aim of our study was to evaluate the expression of mRNA-TSHR in peripheral blood of DTC patients, then to correlate the expression with clinical features: Serum thyroglobulin (sTg) value, initial staging and findings from the whole body scan (WBS), neck ultrasound (US), and total received dose of radioiodine therapy. MATERIALS AND METHODS: Forty patients were divided into three groups according to the treatment response: Patients with incomplete structura

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Cerwenka, Adelheid, Laura L. Carter, Joyce B. Reome, Susan L. Swain, and Richard W. Dutton. "In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines." Journal of Immunology 161, no. 1 (1998): 97–105. http://dx.doi.org/10.4049/jimmunol.161.1.97.

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Abstract Naive CD8 T cells can be polarized into effectors producing the type 1 cytokines IFN-γ and IL-2 or the type 2 cytokines IL-4, IL-5, and IL-10, respectively. To study whether the polarized cytokine phenotype of the effectors is stable, we generated highly cytotoxic hemagglutinin (HA) peptide-specific CD8 Tc1 and Tc2 (cytotoxic CD8 T cells producing type 1 or type 2 cytokines) effectors from Clone-4 TCR-transgenic mice, which were adoptively transferred into syngeneic adult thymectomized irradiated and bone marrow-reconstituted recipients. The highly activated blast-size, CD25+ Tc1 and

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