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Relevant bibliographies by topics / Technology cell therapy / Dissertations / Theses

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Dissertations / Theses on the topic 'Technology cell therapy'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Thorsén, Jenny, Stina Wahlström, Anna Nilsson, Johanna Öberg, and Sebastian Persson. "Immunoassay Applications in Gene and Cell Therapy : A Market Analysis of Companies Conducting Gene and Cell Therapy Product Development." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-352164.

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2

Okamoto, Satoshi. "Investigation of retinal regeneration by cell therapy with the induced pluripotent stem cell technology." Kyoto University, 2013. http://hdl.handle.net/2433/175084.

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3

McCall, Mark J. S. "Cell therapy manufacturing value systems and cost analysis." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/14935.

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Cell Therapies are promising clinical instruments with significant therapeutic potential and commercial promise. However, the industry engaged in their commercial and clinical development faces significant financial, technical, regulatory and market challenges. These challenges are compounded by an understanding gap in the cell therapy industry. Commercial failures and financial difficulties have forced the industry to address the need to provide value and estimate and control costs early in the development timeline. The problem is that this issue is not being systematically or thoroughly addr

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4

Jamshidi, Parastoo. "The formulation of novel calcium phosphate containing culture beads for cell therapy." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5400/.

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Cell therapy has recently gained much attention as a novel treatment method for a range of diseases. Many early examples of mesenchymal stem cell use have focussed on infusion of a cell population and rely on the cells locating to the area of tissue damage. The development of implantable materials in the form of microcarriers to deliver cell populations to the site of injury could help enhance efficacy of treatment. Such carriers may also be used to expand cell populations \(in\) \(vitro\). In this thesis, a range of cell culture beads have been formulated using calcium phosphate ceramics, wit

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5

Sodha, Sonal. "A microfabricated 3-D stem cell delivery scaffold for retinal regenerative therapy." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54593.

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Thesis (M. Eng.)--Harvard-MIT Division of Health Sciences and Technology, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 59-61).<br>Diseases affecting the retina, such as Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP), result in the degeneration of the photoreceptor cells and can ultimately lead to blindness in patients. There is currently no cure for AMD or RP, and only a few methods exist for slowing the progression of these diseases. Although there has been much recent headway in cell replacement therapy to restore vision loss

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6

Hoover, Brett A. "Smart Cellector: A Proposal for the Development and Commercialization of a Cellular Imaging, Analysis and Processing Technology for Application in Regenerative Medicine." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295655205.

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7

Singh, Pawanbir. "Enabling late-stage translation of regenerative medicine based products." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6060.

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The primary aim of the thesis is to contribute to demonstrating how established and emerging science in the regenerative medicine (RM) domain can be translated into profitable commercial practice, and generate clinically- and cost-effective therapies. It achieves this by exploring and assessing underlying economics, including investment readiness and economic assessment, exploring regulatory and reimbursement frameworks, developing stem cell culture systems and assessing fit with clinical practice. The thesis is the first public domain wide-ranging analysis of business trends in the production

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8

Grogg, Julien. "A novel Encapsulated-Cell technology for the delivery of therapeutic proteins : from bench to bedside." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ013.

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La thérapie cellulaire encapsulée présente un grand potentiel pour délivrer des niveaux soutenus de protéines thérapeutiques aux patients et améliorer la gestion des maladies chroniques. Cependant, le saut translationnel vers le succès clinique est entravé par le manque de lignée cellulaire allogénique adaptée aux applications thérapeutiques humaines, ainsi que le manque d'un dispositif d'encapsulation polyvalent, biocompatible, et facile à administrer, à récupérer ou à remplacer. Dans ce travail, nous présentons le développement d'un dispositif de macroencapsulation biocompatible, cargo-agnos

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9

Kravchenko, A. "The use of stem cells in modern medicine." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/62812.

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The list of diseases the treatment of which can be successfully applied stem cell transplantation, increases to several dozen. The focus is on the treatment of malignancies of various forms of leukemia and other blood diseases. There are reports of successful transplantation of stem cells in diseases of the cardiovascular and nervous systems. Developed by international protocols of treatment of multiple sclerosis. Multicenter study conducted in the treatment of myocardial infarction and heart failure. There are searched approaches to treating stroke, Parkinson's disease and Alzheimer's.

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10

Nandlall, Sacha D. "Monitoring cell and tissue damage during ablation by high-intensity focussed ultrasound." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:033693cc-237d-4f84-a891-f121c8e94465.

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High Intensity Focussed Ultrasound (HIFU) ablation is a promising technology for the non-invasive, targeted treatment of certain types of cancer. The technique functions by subjecting tumours to a cytotoxic level of intense, localised heating, while leaving the surrounding tissue unharmed. However, a number of limitations in the available HIFU treatment monitoring methods are currently hampering the effectiveness and clinical adoption of the therapy. This work aims to develop improved metrics of HIFU-induced biological damage that are specifically suited to monitoring and controlling HIFU abla

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11

Hellgren, Sofie. "Impact of cryopreservation and characterization of peripheral blood mononuclear cells and subsets in healthy donors by multicolor flow cytometry analysis." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413035.

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Introduction: Immune therapy plays a larger role in cancer treatment these days, but in order to find new therapies and improve already existing ones, more knowledge about the immune system is needed. The peripheral blood contains many different cell types, some extensively studied, some less well-known. By using multicolor flow cytometry, the immune status of an individual can be displayed in relatively short time. Aim: The aim of this study was to develop a multicolor flow cytometry method in order to examine the distribution of 31 cell types, with a focus on immune regulatory cells, in peri

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12

"Potential of serotonin in stem cell technology and therapy in a mouse ischemic stroke model." 2012. http://library.cuhk.edu.hk/record=b5549580.

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Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in the embryonic neural development and adult neurogenesis. But the effects of 5-HT on stem cells are not fully known. In this study, the effects and underlying signal pathways of 5- HT on proliferation and neural differentiation of mouse embryonic stem (ES) cells, neural progenitor (NP) cell line C 17.2 and embryonic neural stem (NS) cells were explored. Molecular analysis, immunostaining and western blotting revealed that NP/NB cells expressed the rate-limiting enzyme tryptophan hydroxylase (TPH) and produced endogenous 5-H

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13

"Advanced Transitional Cell Carcinoma Treatments Via Expression-targeted Gene Delivery And Minicell Technology." Tulane University, 2014.

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The objective of this project is to develop novel treatments, using expression-targeted gene therapy and minicell technology, to replace current methodologies used in the clinic for the treatment of carcinomas, especially transitional cell carcinoma of the bladder. The expression-targeted gene therapy procedure involves cancer-specific DNA elements (promoters) to drive the expression of engineered suicide genes to induce apoptosis in cancer cells. Minicells, a kind of bacterial derivative , prevent tumor recurrence and growth through targeted toxicity and an induced immune response that is sim

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14

Koldej, Rachel Marie. "The development of HIV-1 derived gene transfer technology: optimisation of vector safety, processing and production." Thesis, 2008. http://hdl.handle.net/2440/42907.

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Vectors derived from Human Immunodeficiency Virus type 1 (HIV-1) are being widely developed for gene therapy applications, principally because they are able to transduce both dividing and non-dividing cells and result in stable, long term gene expression. However, these vectors are difficult to produce in high titres and sufficient volumes for large scale experiments and clinical application. Therefore, an investigation into methods to improve the production of HIV-1 derived gene transfer vectors was undertaken. One factor that limits the production of recombinant virus is the amount of viral

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15

Koldej, Rachel Marie. "The development of HIV-1 derived gene transfer technology: optimisation of vector safety, processing and production." 2008. http://hdl.handle.net/2440/42907.

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Vectors derived from Human Immunodeficiency Virus type 1 (HIV-1) are being widely developed for gene therapy applications, principally because they are able to transduce both dividing and non-dividing cells and result in stable, long term gene expression. However, these vectors are difficult to produce in high titres and sufficient volumes for large scale experiments and clinical application. Therefore, an investigation into methods to improve the production of HIV-1 derived gene transfer vectors was undertaken. One factor that limits the production of recombinant virus is the amount of viral

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16

Abdelfatah, Possnert Heba. "Detection of Thymidine Kinase 1 Activity in Whole Blood Using an Oligonucleotide System." Thesis, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349265.

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In today’s medical science studies, many tumor markers are being used to monitor cancer cell proliferation, but the number of assays for analysis of these markers are few. The aim of this study was to find an easier and more time-efficient way to measure the activity of a specific tumor marker called tymidine kinase 1 (TK1). This tumor marker is an important enzyme involved in cell proliferation and is a key enzyme in the salvage pathway. TK1 activity is related to the occurrence of hematological malignancies and cell activity and therefore have been used as a marker when monitoring this group

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17

Lin, Guan-Cyun, and 林冠群. "Using Parkinson'' s disease (PD) mouse model to rescue alpha-synuclein mutation-induced PD by using a combination of iPS cells technology and gene therapy." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/mfxkgc.

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18

Stasko, Carly. "A Pedagogy of Holistic Media Literacy: Reflections on Culture Jamming as Transformative Learning and Healing." Thesis, 2009. http://hdl.handle.net/1807/18109.

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This qualitative study uses narrative inquiry (Connelly & Clandinin, 1988, 1990, 2001) and self-study to investigate ways to further understand and facilitate the integration of holistic philosophies of education with media literacy pedagogies. As founder and director of the Youth Media Literacy Project and a self-titled Imagitator (one who agitates imagination), I have spent over 10 years teaching media literacy in various high schools, universities, and community centres across North America. This study will focus on my own personal practical knowledge (Connelly & Clandinin, 1982) as a cult

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